CN104435413A - Externally-applied wet tissue for treating measles and preparation method thereof - Google Patents

Externally-applied wet tissue for treating measles and preparation method thereof Download PDF

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CN104435413A
CN104435413A CN201410478692.0A CN201410478692A CN104435413A CN 104435413 A CN104435413 A CN 104435413A CN 201410478692 A CN201410478692 A CN 201410478692A CN 104435413 A CN104435413 A CN 104435413A
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wet tissue
measles
parts
external wet
lacca
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刘兴旺
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/30Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/14Alkali metal chlorides; Alkaline earth metal chlorides
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488Pueraria (kudzu)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007Drug-containing films, membranes or sheets
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    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses an externally-applied wet tissue for treating measles. The externally-applied wet tissue is prepared from the following raw medicinal materials in parts by weight: 5-15 parts of honeysuckle, 15-19 parts of mint, 10-30 parts of radix sophorae flavescentis, 6-16 parts of cortex dictamni, 5-18 parts of brine alkali, 3-9 parts of shellac, 9-18 parts of crocus sativus, 8-14 parts of roots of kudzu vines, 3-9 parts of selaginella tamariscina, 2-8 parts of cimicifugae foetidae and 80-120 parts of non-woven fabrics. The externally-applied wet tissue disclosed by the invention is based on the principle of dialectical therapy of traditional Chinese medicines. The selected medicinal materials not only have sterilizing and itch-relieving medicines, but also have medicines for clearing heat and promoting diuresis as well as medicines for treating eczema. The raw medicinal materials with various functions are matched mutually together to prepare the externally-applied wet tissue disclosed by the invention, so that the externally-applied wet tissue has an extremely good curative effect on measles.

Description

External wet tissue for the treatment of measles and preparation method thereof
Technical field
The present invention relates to traditional Chinese medicine field, especially relate to a kind of external wet tissue for the treatment of measles and preparation method thereof.
Background technology
Be the acute infectious disease caused by Measles virus, infectiousness is extremely strong, is more common in child.Its Clinical symptoms is that heating, rhinorrhea, cough, eye binding film are scorching, occurs special Koplik spot (also known as measles mucous patch) and skin wrinkle pimple widely.The general rehabilitation of measles is smooth, but also can cause severe complication.Ancient Times in China medical book has the record about exanthematous disease very early, and from the Northern Song Dynasty, relevant measles is recorded gradually many, as Qian Yi.Straight rhymed formula examined by children's's medicine " (1023 ~ 1104), and have recognized that measles is a kind of epidemic infectious diseases.13rd century.Is children's varioliform exanthema side discussed? more can distinguish the different of eruption and pox further, and prognosis can be inferred according to rash color.
1. typical measles: (1) incubation period: be generally 10 days ± 2 days (6 ~ 21 days), infect serious or 6 days can be as short as incubation period through blood transfusion acquisition the infected, accepted immune formulation (whole blood, serum, immunoglobulin etc.) or once inoculated Measles Vaccine and fall ill time, then can extend to 3 ~ 4 weeks incubation period.Hiding, 1 ~ 2 day end of term can discharge Measles virus from upper respiratory tract secretions.After contact patients with measles a few hours, can there is temporary mild upper respiratory symptom and low grade fever, even have evanescent eruption in some patient, but very rare.The measles typical case course of disease can be divided into three phases: prodromal period, eruptive stage and convalescent period.(2) prodromal period: generally continue 3 ~ 5 days, weak and serious symptom can extend to 7 ~ 8 days, once inoculated Measles Vaccine or have passive immunity person then can be as short as 1 day.This phase clinically main manifestations be the mucositis symptom of upper respiratory tract (comprising a binding film) inflammation.Have heating, cough, rhinorrhea, drop tears, photophobia etc., with general malaise in various degree.Normal day at low night of generating heat is high, and raise day by day, can reach 39 ~ 40 DEG C, infant hyperpyrexia convulsion can occur, and Annual wool yield or adult often tell headache, giddy, weak, drowsiness.Cough gradually increases the weight of, and is dry cough mostly, and because upper respiratory tract mucosal inflammation is extended down to throat, trachea-bronchial epithelial cell often, hoarse sound is often with in cough, and rapid breathing and difficulty even appear in year child.Normal companion's stomach poor appetite moves back, and even vomits, the gastrointestinal symptom such as diarrhoea.Obviously, within 2 ~ 3 days, Koplik spot can be there is on the cheek mucosa on first molar opposite after morbidity, be the Characteristic signs of measles prodromal period, have measles early diagnosis to be worth in the visible oral cavity of physical examination and the hyperemia of pharyngeal mucosa.This kind tiny oral cavity endanthem, in white, is 0.5 ~ 1mm needle point size, is dispersed on scarlet moistening cheek mucosa.From the beginning of time only several, increase very soon, and can merge, diffuse to whole cheek mucosa, and inside lip, the place such as gingiva, also occasionally on eyelid binding film, seldom betide hard, soft palate.Easily see tiny white point in the sunlight when number of spots is few, around blush, can merge during Numerous in flakes, the cheek mucosa of rarely seen hyperemia have fine salt sample protuberant particles.Koplik spot generally maintains 2 ~ 3 days, rapidly disappears, and within 1 ~ 2 day after eruption sometimes, is also shown in.Few patients sees neck when prodromal period starts, rubella sample appears in breast, abdominal part or scarlet fever sample or measles sample erythra, just disappears, be called forerunner's rash in a few hours.Sometimes can find brownish red speckle at palate vertical (also known as uvula), tonsil, pharynx rear wall, soft palate place, conceal rapidly at the beginning of eruptive stage.(3) eruptive stage: rise and start to occur erythra when respiratory tract mucositis symptom and heating reach peak for 3 ~ 5 days after being ill, be everlasting and see after Koplik spot 1 ~ 2 day.First there is pale red maculopapule from postauricular carbuncle border, gradually and head forehead, face, cervical region, extend to breast, abdomen, the back of the body from top to bottom, finally reach extremity, until palm of the hand sole, within 2 ~ 3 days, just involve whole body.Erythra is based on maculopapule, and during beginning, color is scarlet, and fading of pressure, differs in size, average diameter 2 ~ 5mm, distributes clearly sparse, to erythra increased number during eruption peak, assembles and merges in flakes, color and luster also gradually turns dark, but between rash, skin still belongs to normal, accidental exanthema vesiculosum or tiny hemorrhagic erythra.When being in a bad way, time especially with cardiopulmonary exhaustion, erythra color can turn suddenly dark, and lives in retirement fast.To peak systemic toxicity profiles exacerbation of symptoms with eruption, body temperature raises further, can reach more than 40 DEG C, listless, drowsiness asthenia, or dysphoria all day, and cough increases the weight of to have that expectorant, words are dry, pharynx is extremely congested, the puffiness of the eyes, and secretions is many.Cervical lymph node and hepatosplenomegaly, pulmonary Chang Wengan, moist rales.Chest X-ray, visible mediastinal lymph nodes increases, increased bronchovascular shadows.The natural infection that general kind of vaccine generation the year before last adult less trouble street strain Measles virus causes, eruptive stage, poisoning symptom adult often attached most importance to than children's, and erythra is also all intensive, but concurrent bacterial infects seemingly comparatively infant is few.(4) convalescent period: at simple patients with measles, after erythra and poisoning symptom develop into peak, body temperature often comparatively fast declines in 12 ~ 24h, and patient mental takes a turn for the better thereupon, and respiratory symptom alleviates, but cough often can continue comparatively of a specified duration, and appetite takes a turn for the better greatly.After general temperature decline, 2 ~ 3 days erythra disappear successively by eruption order, leave light brown pigmentation spots, and the tiny desquamation of companion's furfur sample is many with trunk, moves back to the greatest extent in 2 ~ 3 weeks.If without complication, it is 10 ~ 14 days that simple measles moves back the general course of disease from onset to rash.
2. atypical measles: according to Measles virus gene difference, virulence power, enter human body quantity, and patient age size, health status, nutrition are good and bad, the height etc. of immunity, the clinical development process of measles, except being mostly typical measles, still can present following atypical presentation at some cases.(1) heavy measles: mostly because patient's body constitution is weak, have other diseases, malnutrition, hypoimmunity or with Secondary bacterial infections etc., make measles aggravation, as toxic measles, because viral infection of measles is serious, soon namely there is high heat more than 40 DEG C in onset, with serious poisoning symptom, often obnubilation, repeatedly faint from fear, rapid breathing, lip refers to cyanosis, pulse is carefully fast, erythra is intensive, in kermesinus, merges in flakes.Erythra can be hemorrhagic, forms purpura, even occur together visceral hemorrhage, hematemesis, spit blood, to have blood in stool etc. (black measles), erythra is that herpes sample can be fused into bulla (herpes sample measles) sometimes.Some young weak infantile measles erythra is sparse, fail out thoroughly, not and brothers' heart, or erythra is disappeared suddenly, temperature decline lower than room temperature, pale complexion or cinerous (traditional Chinese medical science claims chickenpox with pale complexion), extreme cold of the limbs, mostly because cardiac insufficiency or circulatory failure cause (shock property measles), heart rate is quick, pulse is thin and delicate, irregular respiration or difficulty.Bacillary (staphylococcus aureus) pneumonia of concurrent serious symptom or other viral pneumonias (adenoviral pneumonia) etc. also often belong to serious symptom, and heart failure often occurs, and the state of an illness is heavily endangered, and case fatality rate is high.(2) light-duty measles: mostly because having caused by certain immunity to Measles virus in body, as baby before 6 months still leaves the passive immune antibody from parent, or inject passive immunity preparation in the recent period, or once inoculated Measles Vaccine in the past, and second time infection morbidity person, all can show as mild.Light-duty measles can extend to 3 ~ 4 weeks incubation period, and morbidity is light, and prodromal period is short and not obvious, and respiratory tract mucositis symptom is comparatively light, and Koplik spot is not true to type or does not occur, General Symptoms is slight, does not generate heat or only has low moderate heat.The sparse color of erythra is light, and the course of disease is shorter, little complication, but obtained immunity after being ill, specific antibody rising titre is substantially identical with the typical measles person of trouble.Now confirm that measles also has many inapparent infection or without erythra type measles, can only confirm according to blood serum special antibody increase after being ill.(3) special-shaped measles: mainly occur in inoculated inactivated measles vaccine person in the past, when inoculation contacts measles patients during acute stage after 4 ~ 6 years again, just can cause special-shaped measles.Incubation period is 7 ~ 14 days, and can happen suddenly prodromal period high heat, reaches more than 39 DEG C, companioned with headache, myalgia, stomachache, weak etc., and common cold symptom is not obvious, can have dry cough, mostly without rhinorrhea, tear, eye binding film inflammation etc.Most of patients is without typical Koplik spot.Rise and occur erythra in 2 ~ 3 days after being ill, from distal limbs wrist, ankle, centration diffusion arrives extremity near-end and trunk, below as many, is seldom diffused into the above position of mammary line, occasionally in Head And Face.Erythra is generally in yellowish red color maculopapule, and the exanthema vesiculosum sometimes in 2 ~ 3mm size, has gargalesthesia, do not form a scab when disappearing, and erythra is even in petechia, ecchymosis or measles sample, often accompanies edema of the limbs.Though respiratory symptom is not serious, pulmonary is audible rale sometimes.The visible enlargement of hilar lymph nodes of x-ray inspection and pulmonary's lamellar shade.This kind of pneumonia can continue 1 ~ 2 year repeatedly.Some patient can show as liver, splenomegaly, numb limbs and tense tendons, unable and paralysis, also can not occur obvious erythra clinically, and has other organs disease states.The most important diagnosis basis of primary disease be convalescent period Measles Hemagglutination Inhibition Antibody and complement fixation antibody titre sharply rise.Have the special-shaped patients with measles of report all not find pathogenic Measles virus, epidemiologic data also points out that primary disease is without infectiousness.Primary disease pathogenesis is thought to produce on the basis of host parts immunity to caused by Measles virus allergy at present.Meas/Vac inactivated lacks F protein antigen (formaldehyde destruction that inactivated vaccine adopts F protein) to have research to point out, therefore anti-F protein antibody can not be induced in human body, cause the person that accepts inactivated vaccine to lack and stop Measles virus invasion and the function at host cell internal diffusion, and only produce H protein hemagglutination inhibition antibody (HI).After the inoculation inactivated vaccine several years, HI antibody declines gradually, and when contacting Measles virus once again, HI antibody just rises rapidly in early days, 10 days can up to 1: 1280, but for want of F antibody can not stop virus at spread between cells, and causes special-shaped measles.
The Chinese patent of Authorization Notice No. CN 102961613 B (application number 201210527616.5) discloses a kind of traditional Chinese medicinal lotion for the treatment of children's chronic measles, it is characterized in that this traditional Chinese medicinal lotion is made up of the Chinese medicine of following weight portion: Caulis Celastri glaberis 8-10 part, Herba potamogetonis perfoliati 7-9 part, Herba Marisci compacti 7-9 part, Radix Urticae Cannabinae 13-15 part, Herba Schizonepetae 9-11 part, Radix Scrophulariae 7-9 part, Radix et Rhizoma Gynurae divaricatae 8-10 part, Cortex Dictamni 5-7 part, Radix Berberidis Amurensis 5-7 part, Fructus Arctii 6-8 part, Radix Peucedani 5-7 part, Fructus Tribuli 7-9 part, Rhizoma Gastrodiae 5-7 part, Radix Glycyrrhizae 3-5 part.The Chinese patent of application publication number CN 103083457 A (application number 201210529294.8) discloses a kind of Chinese medicine for the treatment of chronic measles, it is characterized in that it is made up of the component of the material medicine proportioning of following weight: Radix Astragali 30-35g, Rhizoma Atractylodis Macrocephalae 10-15g, salt alkali 15-20g, Herba Schizonepetae 10-15g, Radix Angelicae Sinensis 20-25g, Radix Rehmanniae 25-30g, Cortex Moutan 10-15g, Periostracum Cicadae 25-30g, Bombyx Batryticatus 10-15g, Zaocys 10-15g, Herba Artemisiae Scopariae 15-20g, Radix Glycyrrhizae 10-15g, Radix Sophorae Flavescentis 15-20g, favus skin 25-30g, Radix Tripterygii Wilfordii (the full root of belt leather) 8-10g.
Treatment measles common on market be mostly hormones ointment and some lotions, easily cause stimulation to newborn skin, bring misery to children's, feature of the present invention is that the old and the young can use.
Summary of the invention
For the reason that above-mentioned measles is formed, an object of the present invention is the external wet tissue providing treatment measles, has non-stimulated, effective, is easy to the feature that children's accepts, the present invention adopts Chinese crude drug comparatively common in the localities as raw material, forms through special processing technique manufacture.
Another object of the present invention is just to provide the preparation method of above-mentioned external wet tissue.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The external wet tissue for the treatment of measles, the weight proportion of each crude drug is as follows, is weight portion: Flos Lonicerae 5-15; Herba Menthae 15-19; Radix Sophorae Flavescentis 10-30; Cortex Dictamni 6-16; Salt alkali 5-18; Lacca 3-9; Stigma Croci 9-18; Radix Puerariae 8-14; Herba Lycopodii pulcherrimi 3-9; Rhizoma Cimicifugae 2-8; Non-woven fabrics 80-120.
The external wet tissue of aforementioned therapies measles, preferred scheme, the weight proportion of each crude drug is as follows, is weight portion: Flos Lonicerae 8-13; Herba Menthae 16-18; Radix Sophorae Flavescentis 15-25; Cortex Dictamni 10-12; Salt alkali 10-13; Lacca 5-7; Stigma Croci 12-16 Radix Puerariae 10-12; Herba Lycopodii pulcherrimi 4-8; Rhizoma Cimicifugae 4-6; Non-woven fabrics 90-110.
The external wet tissue of aforementioned therapies measles, better preferred scheme, the weight proportion of each crude drug is as follows, is weight portion: Flos Lonicerae 10; Herba Menthae 17; Radix Sophorae Flavescentis 20; Cortex Dictamni 11; Salt alkali 12; Lacca 6; Stigma Croci 14; Radix Puerariae 11; Herba Lycopodii pulcherrimi 7; Rhizoma Cimicifugae 5; Non-woven fabrics 100.
The preparation method of the external wet tissue for the treatment of measles, step is as follows:
(1) by the utensil of non-woven fabrics speciality, be cut into the square that length and width are all 14-16 centimetre, be placed in the hot water of boiling, high temperature sterilize 1-5 minute, taking-up is dried in the air cool stand-by;
(2) Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, Radix Puerariae and Rhizoma Cimicifugae warm water cleaning, In Shade ventilation 3-6 day, is together placed in crock, add the jowar wine of 30-50 DEG C, sealing and standing 20-40 hour, decocts with water to boiling, the nimble impurity going to crock the top, turn little fire and simmer 20-40 minute slowly, add salt alkali, be heated to rapidly boiling, cease fire after 10 minutes, cross 100-140 order drainage screen, filtrate is stand-by;
(3) step (1) gained non-woven fabrics is placed in step (2) gained filtrate, soaks 10-16 hour, obtain external wet tissue.
The preparation method of above-mentioned external wet tissue, step (1) is cut into the square (being preferably cut into the square that length and width are all 15 centimetres) that length and width are all 14.5-15.5 centimetre.
The preparation method of above-mentioned external wet tissue, step (1) is placed in the hot water of boiling, high temperature sterilize 2-4 minute (preferred, to be placed in the hot water of boiling, high temperature sterilize 3 minutes).
The preparation method of above-mentioned external wet tissue, the crude drug In Shade ventilation 4-5 day (preferred, the In Shade ventilation of crude drug after cleaning 4.5 days) after step (2) is clean.
The preparation method of above-mentioned external wet tissue, step (2) adds the jowar wine of 35-45 DEG C, sealing and standing 25-35 hour (preferred, to add the jowar wine of 40 DEG C, sealing and standing 30 hours).
The preparation method of above-mentioned external wet tissue, the consumption of step (2) jowar wine be Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, Radix Puerariae and Rhizoma Cimicifugae gross weight 1-5 doubly (preferred, the consumption of jowar wine be Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, Radix Puerariae and Rhizoma Cimicifugae gross weight 2-4 doubly, more preferably good, the consumption of jowar wine be Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, Radix Puerariae and Rhizoma Cimicifugae gross weight 3 times).
The preparation method of above-mentioned external wet tissue, step (3) crosses 110-130 order drainage screen (preferred mistake 120 order drainage screen).
Optimum therapeuticing effect is reached for making this medicine, prepare enough warm waters before use, by the clean towel wiping in the place of measles, get the place of a slice wet tissue wiping measles, Chinese medicine can infiltrate skin rapidly, get through acupoint, Quick itch stopping, not easily irritated, use when there is measles and before sleep in evening at every turn, adhere to using and can improve malaise symptoms 2-5 time, within 5 days, can fully recover.
This external wet tissue, to measles Be very effective, has rapid-action, the feature that cure rate is high, using this external wet tissue to have not a particle of uncomfortable sensation, not having any pain when soaking, the local common medical material of multiselect of the present invention, cheap, alleviate the financial burden of patient.
The pharmacological effect of each crude drug is respectively:
Flos Lonicerae: nature and flavor: sweet, cold.Gui Jing: return lung, the heart, stomach warp.Effect: heat-clearing and toxic substances removing, wind-heat dissipating.Curing mainly: for carbuncle furuncle. sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
Herba Menthae: nature and flavor: pungent is cool.Gui Jing: return lung, Liver Channel.Effect: dispelling wind-heat, refresh oneself, rash.Cure mainly: for anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, order skin ulcer, rubella, measles, breast the side of body feeling of distension and oppression.
Radix Sophorae Flavescentis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, liver, stomach, large intestine, urinary bladder channel.Effect: heat clearing and damp drying, parasite killing, diuresis.Cure mainly: for hematodiarrhoea, have blood in stool. jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.
Cortex Dictamni: nature and flavor: bitter, cold.Gui Jing: return spleen, stomach, urinary bladder channel.Effect: heat clearing and damp drying. removing toxic substances of dispeling the wind.Cure mainly: for damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, beriberoid pyretic arthralgia, yellow cellulitis dark coloured urine.
Herba Lycopodii pulcherrimi: base is former: be the herb of the beautiful Phlegmariurus phlegmaria (L) Holub of Huperziaceae Phlegmariurus phlegmaria (L) Holub platymiscium.Composition: containing lycopodium alkaloid and terpenoid.The property of medicine: " Chinese medicinal cryptogam ": " pungent, temperature." function cures mainly: blood stasis dispelling, rash, removing toxic substances.Cure mainly traumatic injury, measles without adequate eruption, innominate toxic swelling.Compatibility and incompatibility of drugs: " Anhui Chinese herbal medicine ": " slightly mild toxicity, and have anesthetic action, dosage for oral administration should be prudent.”
Salt alkali: base is former: for enriched bittern cake (solid salt) decocts through processing the white crystals body made.Composition: be mainly magnesium chloride; Secondly also containing sodium, potassium, calcium, sulfate radical, silicon dioxide, strontium, ferrum etc.Sea salt, lake salt, well salt and salt-soda soil salt four kinds of salt are different with the composition of salt alkali.The property of medicine: bitter, salty, cold.Function cures mainly: clearing away heat-fire, reduces phlegm, softening the hard mass, improving eyesight.Cure mainly large hot excessive thirst, the puckery pain of wind heat conjunctival congestion, Keshan disease, Kaschin-Beck disease, goiter, rheumatic heart disease, hypertension, chronic bronchitis.Compatibility and incompatibility of drugs: apply appropriate to the occasion first low dose of, no more than maximal dose.Generally can not there is great side effect in usual amounts, but xerostomia, nauseating, diarrhoea, erythra etc. appear in some patients section, can take the circumstances into consideration decrement or drug withdrawal., occasionally can there is anaphylaxis phenomenon, as measles, fever etc. in intravenous injection; Small number of patients has pain along injection blood vessel.Individually due to weak, on an empty stomach or menstrual phase, occur after injection that face is pale, be in a cold sweat, even vomit, slightly have a rest after drug withdrawal and can recover.Too fast or the excessive concentration of salt alkali preparation injection speed, all can cause poisoning or lead to grave consequences.Mainly central nervous system's suppressed (suppression of respiratory center is particularly evident) and striped muscle relax, and the paralysis of respiratory muscle can increase the weight of respiration inhibition degree again.Next is suppression and the blood pressure drops of cardiac function.Therefore, the disappearance of corneal reflex and the obvious minimizing of Respiration Rate should regard poisoning Symptoms at Primary Stage as.
Lacca: base is former: the dry colloid of secreting in the tree for Lacciferidae laccifer animal lac insect.Composition: between bar-shaped Lac resinous ten to percent 7 percent 80, between wax content six to percent seven percent, pigment four to percent eight percent.Lac resin can divide hard, soft two kinds, and animi resin accounts for 70 percent, and wherein pure lac resin accounts for 10 etc.The property of medicine: sweet, salty, flat.Function cures mainly: heat clearing away, removing heat from blood, removing toxic substances.Cure mainly measles, macule not saturating, menorrhagia, metrorrhagia, skin infection, eczema.Compatibility and incompatibility of drugs: anemia of pregnant woman is cautious use of.
Stigma Croci: base is former: be the stigma of Rhizoma Iridis Tectori crocus plant Stigma Croci.Composition: stigma is containing volatile oil component more than 30.Also containing pigment: saffron glucoside, crocetin , Fructus Mangifera Indicae glycosides-6 '-O-Stigma Croci acyl group 1 "-O-β-D-Glucose glycosides fat; Sterols: campesterol, stigmasterol etc.Triterpenes: ursolic acid, oleanolic acid; Fatty acid: Palmic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid; Carotenoids: octahydro lycopene, phytofluene, etc.The property of medicine: sweet, flat.GUIXIN, Liver Channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, and dissipating blood stasis unwinds.Cure mainly dysmenorrhea, amenorrhea, menoxenia, post partum longtime lochia, enclosed mass pain in abdomen, injury from falling down, melancholy painful abdominal mass is vexed, and palpitation with fear, epidemic febrile disease sends out speckle, measles.
Radix Puerariae: base is former: be the tuber of pulse family Pueraria Herba Gelsemii Elegantis or Radix Puerariae rattan.Composition: Radix Puerariae is containing flavonoid: daidzein, daiazi, puerarin, 4 '-methoxy puerarin, daidzein-4 ', 7-diglucoside, daidzein-7-glucoside etc.The property of medicine: sweet, pungent, flat.Return spleen, stomach warp.Function cures mainly: expelling pathogenic factors from muscles is delivered, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal.Cure mainly fever caused by exogenous pathogens, rigidity pain on the head and nape, measles goes out smooth from the beginning of, rash, epidemic febrile disease is thirsty, diabetes, has loose bowels, dysentery.
Rhizoma Cimicifugae: base is former: be the rhizome of Ranunculaceae Rattleroot plant C.heracleifolia, Cimicifuga Dahurica and Rhizoma Cimicifugae.Composition: 1. dioicus is mainly containing triterpene and glycoside thereof: Cimicifuga Dahurica deanol, and galactoside, Cimicifuga Dahurica deanol, Rhizoma Cimicifugae Buddhist alcohol, alcohol determined by Rhizoma Cimicifugae, Rhizoma Cimicifugae booth, cyclic-ahltin alkane etc.2. Cimicifuga Dahurica root is mainly containing triterpene and glycoside thereof: Cimidahurine, Rhizoma Cimicifugae epoxy alcohol, Rhizoma Cimicifugae silk glycosides etc.The property of medicine: pungent, sweet, is slightly cold.Return lung, spleen, large intestine, stomach warp.Function cures mainly: deliver rash, heat-clearing and toxic substances removing, ascending up spleen-Qi and Yang.Cure mainly affection due to external wind and heat, headache cold and heat, pharyngalgia, macule, measles is sent out not smooth thoroughly, epidemic disease fire-toxin, aphtha, carbuncle sore tumefacting virus, sinking of QI of middle-JIAO, diarrhea due to hypofunction of the spleen, heavy under chronic dysentery, proctoptosis, visceroptosis, women's leukorrhagia, metrorrhagia.
Non-woven fabrics: non-woven fabrics is also known as adhesive-bonded fabric, be made up of orientation or random fiber, be environment-friendly materials of new generation, there is protection against the tide, ventilative, pliable and tough, light weight, not combustion-supporting, easy decomposition, nontoxic nonirritant, rich color, the feature such as to use again cheap, capable of circulation.As adopted polypropylene (pp material) pellet to be raw material more, batch continuous one-step produce through high-temperature fusion, spray webbing, paving guiding principle, hot pressing.Cloth is called because having the outward appearance of cloth and some performance.
External wet tissue of the present invention debates the principle of disease treatment based on Chinese medicine.The medicine of existing sterilizing and itch-relieving in the medical material selected, has again the medicine of clearing away heat-damp and promoting diuresis, also has the medicine for the treatment of eczema, and the preparation cost invention together that cooperatively interacts of the crude drug of various effect, for the external wet tissue of external, has fabulous therapeutical effect to measles.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1 treats the external wet tissue of measles, and the weight proportion of each crude drug is as follows, is weight portion (getting 10g for every part): Flos Lonicerae 5; Herba Menthae 15; Radix Sophorae Flavescentis 10; Cortex Dictamni 6; Salt alkali 5; Lacca 3; Stigma Croci 9; Radix Puerariae 8; Herba Lycopodii pulcherrimi 3; Rhizoma Cimicifugae 2; Non-woven fabrics 80.
The preparation method of the external wet tissue of above-mentioned treatment measles, step is:
(1) by the utensil of non-woven fabrics speciality, be cut into the square that length and width are all 14 centimetres, be placed in the hot water of boiling, high temperature sterilize 1 minute, taking-up is dried in the air cool stand-by;
(2) Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, Radix Puerariae and Rhizoma Cimicifugae warm water cleaning, In Shade ventilation 3 days, together be placed in crock, add the jowar wine of 30 DEG C, the consumption of jowar wine is Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, Radix Puerariae and Rhizoma Cimicifugae gross weight 1 times, sealing and standing 20 hours, decoct with water to boiling, the nimble impurity going to crock the top, turn little fire and simmer 20 minutes slowly, add salt alkali, be heated to rapidly boiling, cease fire after 10 minutes, cross 100 order drainage screens, filtrate is stand-by,
(3) step (1) gained non-woven fabrics is placed in step (2) gained filtrate, soaks 10 hours, obtain external wet tissue.
Embodiment 2 treats the external wet tissue of measles, and the weight proportion of each crude drug is as follows, is weight portion (getting 15g for every part): Flos Lonicerae 15; Herba Menthae 19; Radix Sophorae Flavescentis 30; Cortex Dictamni 16; Salt alkali 18; Lacca 9; Stigma Croci 18; Radix Puerariae 14; Herba Lycopodii pulcherrimi 9; Rhizoma Cimicifugae 8; Non-woven fabrics 120.
The preparation method of the external wet tissue of above-mentioned treatment measles, step is:
(1) by the utensil of non-woven fabrics speciality, be cut into the square that length and width are all 16 centimetres, be placed in the hot water of boiling, high temperature sterilize 5 minutes, taking-up is dried in the air cool stand-by;
(2) Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, Radix Puerariae and Rhizoma Cimicifugae warm water cleaning, In Shade ventilation 6 days, together be placed in crock, add the jowar wine of 50 DEG C, the consumption of jowar wine is Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, Radix Puerariae and Rhizoma Cimicifugae gross weight 5 times, sealing and standing 40 hours, decoct with water to boiling, the nimble impurity going to crock the top, turn little fire and simmer 40 minutes slowly, add salt alkali, be heated to rapidly boiling, cease fire after 10 minutes, cross 140 order drainage screens, filtrate is stand-by,
(3) step (1) gained non-woven fabrics is placed in step (2) gained filtrate, soaks 16 hours, obtain external wet tissue.
Typical case one: Wu's ××, female, 3 years old, Jinan, Shandong Province Jiyang personage, suffered from measles 1 year, and in this 1 year, always very itch when each morbidity incomparable, slightly generate heat, this is very painful thing for the child of 3 years old.Family members have employed a lot of method and treats to daughter's treatment, has used a lot of external use anti pruritic agent, Calamine Lotion etc., but has not thoroughly cured, and more and more frequently repeatedly, uses gained external wet tissue of the present invention after being introduced.
Use embodiment 2 gained external wet tissue, prepare enough warm waters before use, by the clean towel wiping in the place of measles, get the place of a slice wet tissue wiping measles, Chinese medicine can infiltrate skin rapidly, gets through acupoint, Quick itch stopping, not easily irritated, use when there is measles and before sleep in evening at every turn, uses gained external wet tissue of the present invention 3 times, patient feels so not itched, continuing to employ 3 days, there is measles in patient never again.
Embodiment 3: the external wet tissue for the treatment of measles, the weight proportion of each crude drug is as follows, is weight portion (getting 20g for every part): Flos Lonicerae 8; Herba Menthae 16; Radix Sophorae Flavescentis 15; Cortex Dictamni 10; Salt alkali 10; Lacca 5; Stigma Croci 12; Radix Puerariae 10; Herba Lycopodii pulcherrimi 4; Rhizoma Cimicifugae 4; Non-woven fabrics 90.
The preparation method of the external wet tissue of above-mentioned treatment measles, step is:
(1) by the utensil of non-woven fabrics speciality, be cut into the square that length and width are all 14.5 centimetres, be placed in the hot water of boiling, high temperature sterilize 2 minutes, taking-up is dried in the air cool stand-by;
(2) Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, Radix Puerariae and Rhizoma Cimicifugae warm water cleaning, In Shade ventilation 4 days, together be placed in crock, add the jowar wine of 35 DEG C, the consumption of jowar wine is Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, Radix Puerariae and Rhizoma Cimicifugae gross weight 2 times, sealing and standing 25 hours, decoct with water to boiling, the nimble impurity going to crock the top, turn little fire and simmer 25 minutes slowly, add salt alkali, be heated to rapidly boiling, cease fire after 10 minutes, cross 110 order drainage screens, filtrate is stand-by,
(3) step (1) gained non-woven fabrics is placed in step (2) gained filtrate, soaks 11 hours, obtain external wet tissue.
Embodiment 4 treats the external wet tissue of measles, and the weight proportion of each crude drug is as follows, is weight portion (getting 25g for every part):
Flos Lonicerae 13; Herba Menthae 18; Radix Sophorae Flavescentis 25; Cortex Dictamni 12; Salt alkali 13; Lacca 7; Stigma Croci 16; Radix Puerariae 12; Herba Lycopodii pulcherrimi 8; Rhizoma Cimicifugae 6; Non-woven fabrics 110.
The preparation method of the external wet tissue of above-mentioned treatment measles, step is:
(1) by the utensil of non-woven fabrics speciality, be cut into the square that length and width are all 15.5 centimetres, be placed in the hot water of boiling, high temperature sterilize 4 minutes, taking-up is dried in the air cool stand-by;
(2) Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, Radix Puerariae and Rhizoma Cimicifugae warm water cleaning, In Shade ventilation 5 days, together be placed in crock, add the jowar wine of 45 DEG C, the consumption of jowar wine is Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, Radix Puerariae and Rhizoma Cimicifugae gross weight 4 times, sealing and standing 35 hours, decoct with water to boiling, the nimble impurity going to crock the top, turn little fire and simmer 35 minutes slowly, add salt alkali, be heated to rapidly boiling, cease fire after 10 minutes, cross 130 order drainage screens, filtrate is stand-by,
(3) step (1) gained non-woven fabrics is placed in step (2) gained filtrate, soaks 15 hours, obtain external wet tissue.
Model case two: woods ××, man, 12 months large.Measles of falling ill in May, 2011 2 months, ate 2 months Chinese medicine, period in a medicine effect is fine, after drug withdrawal, the state of an illness is serious all the more, sees eating calcium tablet and VC is effective on the net, once takes medicine one month but do not get better to turn, from then on cure the disease and lose the confidence, hearing that the son of friend had cured afterwards, how curing, until this spring is to learning external wet tissue of the present invention so ask about to others always.
Use embodiment 4 gained external wet tissue, prepare enough warm waters before use, by the clean towel wiping in the place of measles, get the place of a slice wet tissue wiping measles, Chinese medicine can infiltrate skin rapidly, gets through acupoint, Quick itch stopping, not easily irritated, use when there is measles and before sleep in evening at every turn, use gained external wet tissue of the present invention 5 times, patient's sensory symptoms improves substantially, continue use 10 times, there is measles never again in patient, even if eat pungent also having nothing to do.
Embodiment 5: the external wet tissue for the treatment of measles, the weight proportion of each crude drug is as follows, is weight portion (getting 30g for every part): Flos Lonicerae 10; Herba Menthae 17; Radix Sophorae Flavescentis 20; Cortex Dictamni 11; Salt alkali 12; Lacca 6; Stigma Croci 14; Radix Puerariae 11; Herba Lycopodii pulcherrimi 7; Rhizoma Cimicifugae 5; Non-woven fabrics 100.
The preparation method of the external wet tissue of above-mentioned treatment measles, step is:
(1) by the utensil of non-woven fabrics speciality, be cut into the square that length and width are all 15 centimetres, be placed in the hot water of boiling, high temperature sterilize 1-5 minute, taking-up is dried in the air cool stand-by;
(2) Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, Radix Puerariae and Rhizoma Cimicifugae warm water cleaning, In Shade ventilation 4.5 days, together be placed in crock, add the jowar wine of 40 DEG C, the consumption of jowar wine is Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, Radix Puerariae and Rhizoma Cimicifugae gross weight 3 times, sealing and standing 30 hours, decoct with water to boiling, the nimble impurity going to crock the top, turn little fire and simmer 30 minutes slowly, add salt alkali, be heated to rapidly boiling, cease fire after 10 minutes, cross 120 order drainage screens, filtrate is stand-by,
(3) step (1) gained non-woven fabrics is placed in step (2) gained filtrate, soaks 14 hours, obtain external wet tissue.
Experimental example (embodiment 5 gained external wet tissue): in order to verify the effect of external wet tissue of the present invention, we have extracted 400 patients in 4 hospitals and have carried out the experiment of medicine, test group 200 people, matched group 200 people, experimental group uses embodiment 5 gained external wet tissue, and matched group uses the medicine (medicine as conventional therapy measles such as external use anti pruritic agent, Calamine Lotion) of other treatment measles.Inclusion criteria: through being diagnosed as patients with measles, has measles clinical symptoms one or more.Using method: reach optimum therapeuticing effect for making this medicine, prepare enough warm waters before use, by the clean towel wiping in the place of measles, get the place of a slice wet tissue wiping measles, Chinese medicine can infiltrate skin rapidly, get through acupoint, Quick itch stopping, not easily irritated, use when there is measles and before sleep in evening at every turn, adhere to using and can improve malaise symptoms 2-5 time, within 5 days, can fully recover.Curative effect situation criterion: 1, cure, after using this product, malaise symptoms disappears completely; 2, effective, after using this product, malaise symptoms alleviates or partial disappearance; 3, invalid, after using this product, malaise symptoms is unchanged.We have carried out accurate statistics and mathematical analysis to experimental data.Specific experiment result is as following table: table 1: two groups of Clinical efficacy comparison [example] tables 1
External wet tissue of the present invention has significant curative effect to treatment measles, measles pediatric patient in various degree can be treated, total effective rate is up to 98%, cure rate is up to 96%, severe patient is after use gained external wet tissue of the present invention 3 times, and symptom also can alleviate, and the external wet tissue of this invention is cheap, evident in efficacy, the present invention a kind ofly treats measles safety and external wet tissue without any side effects.

Claims (10)

1. treat the external wet tissue of measles, it is characterized in that: the weight proportion of each crude drug is as follows, is weight portion: Flos Lonicerae 5-15; Herba Menthae 15-19; Radix Sophorae Flavescentis 10-30; Cortex Dictamni 6-16; Salt alkali 5-18; Lacca 3-9; Stigma Croci 9-18; Radix Puerariae 8-14; Herba Lycopodii pulcherrimi 3-9; Rhizoma Cimicifugae 2-8; Non-woven fabrics 80-120.
2. the external wet tissue for the treatment of measles according to claim 1, is characterized in that: the weight proportion of each crude drug is as follows, is weight portion: Flos Lonicerae 8-13; Herba Menthae 16-18; Radix Sophorae Flavescentis 15-25; Cortex Dictamni 10-12; Salt alkali 10-13; Lacca 5-7; Stigma Croci 12-16 Radix Puerariae 10-12; Herba Lycopodii pulcherrimi 4-8; Rhizoma Cimicifugae 4-6; Non-woven fabrics 90-110.
3. the external wet tissue for the treatment of measles according to claim 1, is characterized in that: the weight proportion of each crude drug is as follows, is weight portion: Flos Lonicerae 10; Herba Menthae 17; Radix Sophorae Flavescentis 20; Cortex Dictamni 11; Salt alkali 12; Lacca 6; Stigma Croci 14; Radix Puerariae 11; Herba Lycopodii pulcherrimi 7; Rhizoma Cimicifugae 5; Non-woven fabrics 100.
4. the preparation method of the external wet tissue of the treatment measles according to any one of claim 1-3, is characterized in that: step is as follows:
(1) by the utensil of non-woven fabrics speciality, be cut into the square that length and width are all 14-16 centimetre, be placed in the hot water of boiling, high temperature sterilize 1-5 minute, taking-up is dried in the air cool stand-by;
(2) Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, Radix Puerariae and Rhizoma Cimicifugae warm water cleaning, In Shade ventilation 3-6 day, is together placed in crock, add the jowar wine of 30-50 DEG C, sealing and standing 20-40 hour, decocts with water to boiling, the nimble impurity going to crock the top, turn little fire and simmer 20-40 minute slowly, add salt alkali, be heated to rapidly boiling, cease fire after 10 minutes, cross 100-140 order drainage screen, filtrate is stand-by;
(3) step (1) gained non-woven fabrics is placed in step (2) gained filtrate, soaks 10-16 hour, obtain external wet tissue.
5. the preparation method of external wet tissue according to claim 4, is characterized in that: step (1) is cut into the square (being preferably cut into the square that length and width are all 15 centimetres) that length and width are all 14.5-15.5 centimetre.
6. the preparation method of external wet tissue according to claim 4, is characterized in that: step (1) is placed in the hot water of boiling, high temperature sterilize 2-4 minute (preferred, to be placed in the hot water of boiling, high temperature sterilize 3 minutes).
7. the preparation method of external wet tissue according to claim 4, is characterized in that: the crude drug In Shade ventilation 4-5 day (preferred, the In Shade ventilation of crude drug after cleaning 4.5 days) after step (2) is clean.
8. the preparation method of external wet tissue according to claim 4, is characterized in that: step (2) adds the jowar wine of 35-45 DEG C, sealing and standing 25-35 hour (preferred, to add the jowar wine of 40 DEG C, sealing and standing 30 hours).
9. the preparation method of external wet tissue according to claim 4, it is characterized in that: the consumption of step (2) jowar wine is Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, the 1-5 of Radix Puerariae and Rhizoma Cimicifugae gross weight is doubly (preferred, the consumption of jowar wine is Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, the 2-4 of Radix Puerariae and Rhizoma Cimicifugae gross weight doubly, more preferably good, the consumption of jowar wine is Flos Lonicerae, Herba Menthae, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Lycopodii pulcherrimi, Lacca, Stigma Croci, Radix Puerariae and Rhizoma Cimicifugae gross weight 3 times).
10. the preparation method of external wet tissue according to claim 4, is characterized in that: step (3) is soaked 11-15 hour (preferably soaking 14 hours).
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