CN102614435B - Chinese medicinal aerosol for treating acute attack of pulmonary heart disease and preparation method thereof - Google Patents
Chinese medicinal aerosol for treating acute attack of pulmonary heart disease and preparation method thereof Download PDFInfo
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Abstract
The invention provides a method for preparing Chinese medicinal aerosol for treating acute attack of pulmonary heart disease. The method comprises the following steps of: (1) preparing Chinese medicinal extract; (2) preparing medicinal additives; and (3) preparing the aerosol. The method has the advantages that the selected materials are traditional Chinese medicinal materials, so the aerosol does not have any toxic or side effect; the formula is completely in accordance with Chinese medicinal principles and physical and mental characteristics of pulmonary heart disease and heart disease patients; and on the premise of general guidelines, the aerosol can have different formulas according to different crowds and have different functions. The medicament sources are readily available, the costs of the medicinal materials are low, and the burden of the patients can be lightened. The aerosol has a quick curative effect, and is particularly suitable for acute attack of the pulmonary heart disease.
Description
Technical field
The present invention relates to the Chinese medicine field, particularly relate to a kind of Traditional Chinese medicinal aerosol for the treatment of acute episode of cor pulmonale by combination and preparation method thereof.
Background technology
The most common person of chronic pulmonary heart disease is the courageous and upright pulmonary heart disease of chronic hypoxia, claim again obstructive emphysema heart disease, be called for short pulmonary heart disease, refer to be increased by the pulmonary vascular resistance that pulmonary's thorax or Pulmonic chronic disease cause, cause pulmonary hypertension and right ventricular hypertrophy, companion or without a class heart disease of right heart failure.Pulmonary heart disease is commonly encountered diseases in China, frequently-occurring disease.
The Early manifestation of chronic cardiopulmonary disease is long-term cough, expectoration and dyspnea in various degree, particularly movable after or in cold season symptom more obvious.Pulmonary heart disease early stage, cardio-pulmonary function are in generation and taste the phase, and the patient does not have specific symptom, and patient can not have symptom when quiet, so this disease is difficult for coming into the picture.But as long as following situation occurs, often prompting has suffered from pulmonary heart disease: 1, prolonged and repeated cough, expectoration.2, every cold season aggravation, the cough aggravation, amount of expectoration increases, thickens or is yellow.3, movable a little as when going upstairs or walking at a quick pace, feel to breathe hard, rapid breathing, cardiopalmus, precordialgia, the symptom such as weak, uncomfortable in chest, can take a turn for the better after rest.4, finger tip, lip and lip surrounding are livid purple color.5, heart rate is accelerated, arrhythmia.Pulmonary heart disease can cause heart change: right ventricular hypertrophy, locular wall thicken, dilatation of heart, pulmonary conus bulge, cardiac muscle fiber have the changes such as hypertrophy and atrophy, interstitial edema, and the kitchen range type is downright bad, is substituted by fibrous tissue after necrosis region.Some patients were can merge coronary artery lesion.
The treatment of pulmonary heart disease with antitussive, eliminate the phlegm, relieving asthma and the symptomatic treatment such as infection.Or use to improve as subcutaneous in nucleic acid casein injection (or expired measles attenuated vaccine) or the intramuscular injection of immunity of organisms medicine and (or) atomizing sucks, each 2～4ml, the casein of secondary, or nucleic acid weekly oral liquid 10ml/ props up, 3 times/d, be a course for the treatment of 3～June.Vaccinum Bronehitidis subcutaneous injection, immune ribonucleic acid, placental lipo-glucosaminoglycan intramuscular injection, Radix Ginseng, transfer factor, levamisole are oral etc.
Compare with western medicine and medical practitioners, by Chinese traditional treatment, toxic and side effects is lighter, is more vulnerable to numerous medical personnels and friend's patient favor.The Chinese patent literature of Granted publication CN 1294926C (application number 200410015856.2) provides a kind of formula of Chinese medicine composition for the treatment of pulmonary heart disease and has prepared native skill, comprise stock and adjunct, the composition of raw materials proportioning is Radix Astragali 1-5 part, Semen Lepidii (Semen Descurainiae) 1-5 part, Rhizoma Chuanxiong 1-5 part, draw together building skin 1-5 part and adjuvant forms.the Chinese patent literature of application publication number CN 102145044A (application number 201110096779.8) provides a kind of compound spray for the treatment of cardiovascular and cerebrovascular disease, it is that alcoholic solution by crude drug is aided with the pharmaceutic adjuvant wiring solution-forming and makes, described crude drug is comprised of Radix Salviae Miltiorrhizae extract and the 32-75% Radix Notoginseng total arasaponins of 25%-68%, by weight percentage: described pharmaceutic adjuvant contains solubilizing agent and propellant, wherein solubilizing agent accounts for the 1-100% of total solution weight, described solubilizing agent is poly-Pyrusussuriensis vinegar class, the smooth class of fatty acid Pyrusussuriensis, the cruel class of polyoxyethylene fatty acid, the polyoxyethylene aliphatic alcohol ether class, one or more of polyoxyethylene one polyoxypropylene copolymer.The Chinese patent literature of publication number CN 1353981A (application number 01130411.1) relates to a kind of quick-acting aerosol for resisting angina cordis and preparation method thereof, that propellant is turned to HFC from CFCs, when namely eliminating earth depletion of the ozone layer probability, a kind of quick-acting anti-heart stricture of vagina pain aerosols and preparation method thereof are proposed.Publication number CN 1276207A (application number 99107980.9) discloses a kind of preparation method that is used for the treatment of the Traditional Chinese medicinal aerosol of coronary heart diseases and angina pectoris.This aerosol adopts to be made mixed solvent with Styrax, Borneolum Syntheticum with ethanol and glycerol and dissolves, and is sub-packed in the new technology in the aerosol pressure bottle and makes.The Chinese patent literature of application publication number CN 102370673A (application number 201010259735.8) provides a kind of Chinese medicine compound new drug Su Bing (fast-acting heart disease curing) spray and preparation method thereof, has the anginal good therapeutical effect of resisting coronary heart disease.Prescription is by Styrax, Borneolum Syntheticum, solubilizing agent, absorption enhancer, solvent composition, with almost completely water-fast Borneolum Syntheticum and not with the Storax oil of water immiscible phase by a dissolving, a breast simple new technology such as even with its jointly be dissolved in can be oral water-soluble base in, the oral administration solution that makes is transparent and homogeneous solution, the not stratified suspension that also do not present.The Chinese patent literature of application publication number CN 102302528A (application number 201110285508.7) discloses a kind of spray of preventing and treating asthma and preparation method thereof, this spray comprises Radix Angelicae Sinensis volatile oil, and take the effective site of Radix Angelicae Sinensis volatile oil as relievining asthma, also comprise the adjuvant that preparation allows, through steps such as weighing, mixing standardize solution, emulsifyings, be made into spray emulsion.The Chinese patent literature of application publication number CN 102335132A (application number 201110308016.5) discloses a kind of Asarin inhalation aerosol and preparation method thereof.Described Asarin inhalation aerosol is made by following a certain proportion of weight portion raw material: asarone, propellant, cosolvent, antioxidant, correctives, antibacterial, described propellant are HFA-134a or HFA-227.
Although the medicine that provides in prior art more or less all has some curative effects on the treatment pulmonary heart disease, the part prescription brings certain toxic and side effects more or less can for patient's gastrointestinal, Liver and kidney.And some drugs exists takes the defectives such as inconvenience, onset is slow.
Summary of the invention
For the deficiencies in the prior art, the purpose of this invention is to provide and a kind ofly prepare simple, taking convenience, be easy to carry, easy Traditional Chinese medicinal aerosol of the treatment acute episode of cor pulmonale by combination of clothes and preparation method thereof for a long time.This Chinese medicine composition determined curative effect and having no side effect.Than other preparations absorb fast, rapid-action, can bring into play faster and better curative effect, be suitable for, medication when pulmonary angina pectoris, myocardial ischemia patient acute attack, onset time shortens to 60 seconds greatly with interior (some patients were is taken 10s with the interior produce effects that gets final product), provides a good therapeutic new drug to the acute attack of present China pulmonary heart disease.
Technical scheme of the present invention is: the preparation method of the Traditional Chinese medicinal aerosol for the treatment of acute episode of cor pulmonale by combination comprises step:
(1) preparation Chinese medicine extraction liquid: take off and state raw material and add water 1500-2200 part (preferred 1800-2000 part), decocts 20-45 minute (preferred 25-40 minute), filtrate concentrates, be weight portion: Semen Coicis 20-45, Rhizoma Phragmitis 20-45, Semen Persicae 6-12, Semen Benincasae 20-45, Pumex 20-45, Semen Trichosanthis 20-26, Semen Lepidii (Semen Descurainiae) 20-30, Radix Stemonae 6-12, Semen Armeniacae Amarum 6-15, Radix Ginseng 2-6, Radix Ophiopogonis 12-25, Fructus Schisandrae Chinensis 3-9, Bulbus Fritillariae Uninbracteatae 6-12, Rhizoma Anemarrhenae 10-20;
(2) preparation medical additive: take off and state raw material and mix and grind and be fine powder, be weight portion: Moschus 0.02-0.08, Borneolum Syntheticum 0.05-0.3;
(3) preparation spray: medical additive is placed in the Chinese medicine extraction liquid mix homogeneously, and the consumption of medical additive is the 0.5-3% of Chinese medicine extraction liquid weight, is aided with pharmaceutically acceptable carrier (or adjuvant) and packs and get.
Described preparation method, preferred scheme is, each raw material in step (1): Semen Coicis 25-35, Rhizoma Phragmitis 25-35, Semen Persicae 9-10, Semen Benincasae 25-35, Pumex 25-35, Semen Trichosanthis 22-24, Semen Lepidii (Semen Descurainiae) 22-28, Radix Stemonae 9-10, Semen Armeniacae Amarum 9-12, Radix Ginseng 3-5, Radix Ophiopogonis 15-20, Fructus Schisandrae Chinensis 5-8, Bulbus Fritillariae Uninbracteatae 9-10, Rhizoma Anemarrhenae 12-15 (preferred Rhizoma Anemarrhenae 12-13).Be more preferably each raw material in step (1): Semen Coicis 30, Rhizoma Phragmitis 30, Semen Persicae 9.5, Semen Benincasae 30, Pumex 30, Semen Trichosanthis 23, Semen Lepidii (Semen Descurainiae) 26, the Radix Stemonae 9.5, Semen Armeniacae Amarum 10, Radix Ginseng 4, Radix Ophiopogonis 18, Fructus Schisandrae Chinensis 6, Bulbus Fritillariae Uninbracteatae 9.5, the Rhizoma Anemarrhenae 13.
Described preparation method, preferred scheme is, each raw material in step (2): Moschus 0.04-0.06, Borneolum Syntheticum 0.1-0.2.Be more preferably Moschus 0.05, Borneolum Syntheticum 0.15.
Described preparation method, preferably scheme is, in step (3), the consumption of medicinal additive is the 1-2% (preferred 1.2-1.8%) of Chinese medicine extraction liquid weight.Be more preferably, the consumption of medical additive is 1.5% of Chinese medicine extraction liquid weight.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Semen Coicis: nature and flavor: sweet, light.Cool.Gui Jing: return spleen, stomach, lung meridian.Effect: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, clearing away heat and discharging pus.Cure mainly: be used for edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, pain in the lung, intestinal carbuncle; Verruca plana." book on Chinese herbal medicine is stated ": Semen Coicis, dehumidifying and not as two arts help dry, heat clearing away and not as a kind of reed mentioned in ancient books, connect the generation and damage the moon, QI invigorating and still grow damp and hotly not as ginseng, art generation is really gas key medicine in benefit.So it is lightly seasoned, and its power is slow, and with Ji, thick collection is to throw as unsocial, its right effect of playing of Ji also? " book on Chinese herbal medicine newly organized ": the kind diuretic of Semen Coicis, the gas that unlikely loss is Kidney-Yin, all wet persons that is contained in the lower part of the body the most suitablely use it, depending on the weight of disease, few more than mutatis mutandis medicine, negative and positive are not hindered, and damp disease is easily gone.Therefore the disease that all chance water is wet is monarch with Semen Coicis one, two liang, and the flavor that the spleen invigorating of assistant is dried, do not have not fast in the person of proving effective also, if thin its abnormal smells from the patient gentle and gently use it is also unhelpful.
Rhizoma Phragmitis: nature and flavor: sweet, cold.Gui Jing: attach to the lung and stomach meridians.Effect: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: be used for the calentura excessive thirst, the gastric heat sound of vomiting of vomitting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.
Semen Persicae: nature and flavor: bitter, sweet, flat.Gui Jing: GUIXIN, liver, large intestine channel.Effect: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.Cure mainly: be used for amenorrhea. dysmenorrhea. mass in the abdomen mass in the abdomen, injury from falling down, dryness of the intestine constipation.Modern study, it contains amygdalin (Amygdalin), emulsin (Emulsin), allantoinase (Allantoinase), Lactose enzyme (Lactase), vitamin B1. volatile oil, fatty oil, mainly containing olein and a small amount of glyceryl linoleate in oil. emulsin comprises amygdalase (Amygdalase) and prunase (Prunase). the amygdalin in Semen Persicae is the same with amygdalin in Semen Armeniacae Amarum, produces hydrocyanic acid, benzaldehyde and glucose after enzyme or acid hydrolysis.
Semen Benincasae: be the seed of cucurbitaceous plant Fructus Benincasae.Property is sweet, cool.Cold, nontoxic.Enter meridian of Foot-JUE YIN.But removing heat from the lung and dissipating phlegm; The eliminating carbuncle evacuation of pus; Dampness removing.Main phlegm-heat cough; Lung abscess; The intestinal carbuncle; Nebulousurine; Leukorrhagia; Foot gas; Edema; Stranguria.
Pumex: another name spray (supplement to the Herbal), white Pumex, Pumex, Hai Shi (" danxi's experiential therapy "), blister stone (" Dong-eui-bo-gam "), large Pumex, Pumex (" beautiful Chinese catalpa medicine solution "), PUMEX (" the medical center bun is wanted "), Gaster caprae seu Ovis stone (" medical material compilation of data ").Gui Jing: lung; Kidney; Liver; Large intestine channel.Nature and flavor: salty, cold.The lung heat clearing fire is changed old expectorant, and softening the hard mass is treating stranguria.Control the expectorant dyspnea of heat type and cough, old accumulation of phlegm piece, goiter, scrofula, gonorrhea, hernia, skin ulcer is swollen, corneal nebula.Removing heat from the lung and dissipating phlegm, hard masses softening and resolving.Be used for the cough due to lung-heat, yellowish thick sputum, spitting of blood, bronchitis, tuberculous lymphadenitis.Medical material divides Pumex and coral two classes.Pumex is the formed stone of magma that volcanic eruption goes out; Coral is the dry skeleton of the born of the same parents animal costazia aculeata Canu et Bassler Costazia aculeataCanu et Bassler of section or costazia costazii Audouin Costazia costazii Audouin.Pumex can be adopted the whole year, pulls out from marine, chooses only and dries.Autumn in coral summer is pulled out from marine, and clear water washes away salt matter and silt, dries.
Fructus Trichosanthis (core): feeble QI, sweet in the mouth, little bitterness.Compendium of Material Medica volume 18 years: Fructus Trichosanthis " lung moistening is dry, pathogenic fire reducing, control that cough, clearing away phlegm ties, only quenched one's thirst, sharply defecate, the subduing inflammation sore ".Modern medicine and pharmacology studies confirm that: Fructus Trichosanthis contains unsaturated fatty acid 16.8%, protein 5.46%, and contain 17 seed amino acids, three paste Saponin, 16 kinds of trace element such as multivitamin and calcium, ferrum, zinc, selenium.Edible Fructus Trichosanthis (core) has expansion heart arteria coronaria, increases the coronary flow effect; Acute myocardial ischemia there is significant protective effect; Exsomatize choriocarcinoma cell propagation and HIV (human immunodeficiency virus) had strong inhibitory action.
Semen Lepidii (Semen Descurainiae): nature and flavor: hot, bitter, Great Cold.Gui Jing: return lung, urinary bladder channel.Effect: dirty lung is relievingd asthma, line water detumescence.Cure mainly: be used for sputum and stop up lung, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium must not be put down sleepingly, and ascites pleural fluid is swollen, dysuria; The pulmonary heart disease edema.
The Radix Stemonae: nature and flavor: sweet, bitter, tepor.Gui Jing: return lung meridian.Effect: nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Cure mainly: be used for new chronic cough and cough, pulmonary tuberculosis cough, pertussis; Outer head louse, body louse, enterobiasis, the pudendal pruritus of being used for.Honey Radix Stemonae nourishing the lung to arrest cough.Be used for deficiency of YIN chronic cough.
Semen Armeniacae Amarum nature and flavor: hardship, tepor; Slightly poisonous.Gui Jing: return lung, large intestine channel.Effect: sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.Curing mainly: be used for cough and asthma. the fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, the dryness of the intestine constipation.
Borneolum Syntheticum (natural Broneolum Syntheticum): property is arduous, and is cool.Can " treat sore throat, headache, breath, toothache, the typhoid fever protrusion of the tongue, children's's pox falls into.Logical all keys, loose stagnated fire." (" detailed outline ").
Radix Ginseng: nature and flavor: sweet, little hardship, flat.Gui Jing: return spleen, lung, heart channel.Effect: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, and calms the nerves.Cure mainly: be used for weak body and prostration, the cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, and prolonged illness is empty wins, the palpitation with fear insomnia, sun layer official is cold; Heart failure, cardiogenic shock.
Radix Ophiopogonis: nature and flavor: sweet, little hardship is slightly cold.Gui Jing: GUIXIN, lung, stomach warp.Effect: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Cure mainly: be used for dryness of the lung dry cough.The chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, the dryness of the intestine constipation; Pharyngeal diphtheria.
Fructus Schisandrae Chinensis: nature and flavor: sour, sweet, temperature.Gui Jing: return lung, the heart, kidney channel.Effect: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Cure mainly: be used for the chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Bulbus Fritillariae Uninbracteatae (Bulbus Fritillariae Thunbergii): nature and flavor: hardship, cold.Gui Jing: return lung, heart channel.Effect: heat clearing away eliminating stagnation. preventing phlegm from forming and stopping coughing cures mainly: be used for wind-heat invading the lung, phlegm-fire cough, lung abscess, mastalgia, scrofula, sore.
The Rhizoma Anemarrhenae: nature and flavor: bitter, sweet, cold.Gui Jing: return lung, stomach, kidney channel.Effect: clearing away heat-fire, promote the production of body fluid and moisturize.Cure mainly: be used for fever caused by exogenous pathogenic factors. high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, the dryness of the intestine constipation.
Spray prescription science provided by the invention, the preparation method of dosage form can be with reference to existing document, the products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, selected materials is all the Chinese medicine material, and is without any side effects;
2, this prescription meets Chinese medicine principle and pulmonary heart disease, cardiac's body and mind characteristics fully, under the prerequisite of general principle, can different prescriptions be arranged according to different crowd, and function is different.
3, the medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
4, curative effect is rapid, is particularly suitable for the acute attack of pulmonary heart disease, angina pectoris, myocardial ischemia.
The specific embodiment
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
The preparation method of the Traditional Chinese medicinal aerosol of embodiment 1 treatment acute episode of cor pulmonale by combination comprises step:
(1) preparation Chinese medicine extraction liquid: take off and state raw material and add 2200 parts, water, decocted 45 minutes, filtrate concentrates, be weight portion (every part of 20g): Semen Coicis 20, Rhizoma Phragmitis 20, Semen Persicae 6, Semen Benincasae 20, Pumex 20, Semen Trichosanthis 20, Semen Lepidii (Semen Descurainiae) 20, the Radix Stemonae 6, Semen Armeniacae Amarum 6, Radix Ginseng 2, Radix Ophiopogonis 12, Fructus Schisandrae Chinensis 3, Bulbus Fritillariae Uninbracteatae 6, the Rhizoma Anemarrhenae 10;
(2) preparation medical additive: take off and state raw material and mix and grind and be fine powder, be weight portion (every part of 20g): Moschus 0.08, Borneolum Syntheticum 0.3;
(3) preparation spray: medical additive is placed in the Chinese medicine extraction liquid mix homogeneously, the consumption of medical additive is 3% of Chinese medicine extraction liquid weight, be aided with pharmaceutically acceptable carrier (such as solubilizing agent, deodorizer, lytic agent, propellant etc. all can obtain, packing used also can be selected suitable material) packing and get from prior art.
Instructions of taking of the present invention: for the treatment chronic cardiopulmonary disease, every day, intermittence was taken, and sprayed into the oral cavity when taking, and contained 5-10 after second, swallowed every day 5-12 time, each 5ml-20ml.During acute episode of cor pulmonale by combination, spray into the oral cavity and swallow, each 5ml-20ml gets final product relief of symptoms a moment later.
The preparation method of the Traditional Chinese medicinal aerosol of embodiment 2 treatment acute episode of cor pulmonale by combinations comprises step:
(1) preparation Chinese medicine extraction liquid: take off and state raw material and add 1500 parts, water, decocted 20 minutes, filtrate concentrates, be weight portion (every part of 30g): Semen Coicis 45, Rhizoma Phragmitis 45, Semen Persicae 12, Semen Benincasae 45, Pumex 45, Semen Trichosanthis 26, Semen Lepidii (Semen Descurainiae) 30, the Radix Stemonae 12, Semen Armeniacae Amarum 15, Radix Ginseng 6, Radix Ophiopogonis 25, Fructus Schisandrae Chinensis 9, Bulbus Fritillariae Uninbracteatae 12, the Rhizoma Anemarrhenae 20;
(2) preparation medical additive: take off and state raw material and mix and grind and be fine powder, be weight portion (every part of 30g): Moschus 0.02, Borneolum Syntheticum 0.05;
(3) preparation spray: medical additive is placed in the Chinese medicine extraction liquid mix homogeneously, and the consumption of medical additive is 0.5% of Chinese medicine extraction liquid weight, is aided with pharmaceutically acceptable carrier package and gets.
Model case: xxx, male, 73 years old age.Chronic cough, expectoration and asthma history are arranged, weak, dyspnea progressively occurs.Health check-up shows obvious emphysema performance, comprises that barrel chest, pulmonary's percussion are that excessive sore throat relieving, the liver dullness upper bound descends, border of cardiac dullness dwindles, and even disappear.The auscultation respiratory murmur is low, and dried moist rale can be arranged, and hear sounds is light.Pulmonary area the second sound is hyperfunction, and obvious heartbeat is arranged under the epigastrium xiphoid-process, is the main manifestations that pathological changes is involved heart.Typical pulmonary heart disease functional compensation phase patient.
Take the Traditional Chinese medicinal aerosol of the present embodiment gained treatment acute episode of cor pulmonale by combination, 7 days courses for the treatment of.Took 21 days, chest pain, cough alleviate, and confusingly in the heart also alleviate, and the amount of receiving increases, spirit can, took 5 months, symptom is eliminated, the peace of sleeping night, vexed removing, strength increases, receive food can, continuing takes 12 months, does not occur any discomfort when the patient takes, the self-induction recovery from illness.
The preparation method of the Traditional Chinese medicinal aerosol of embodiment 3 treatment acute episode of cor pulmonale by combinations comprises step:
(1) preparation Chinese medicine extraction liquid: take off and state raw material and add 1800 parts, water, decocted 25 minutes, filtrate concentrates, be weight portion (every part of 5g): Semen Coicis 25, Rhizoma Phragmitis 25, Semen Persicae 9, Semen Benincasae 25, Pumex 25, Semen Trichosanthis 22, Semen Lepidii (Semen Descurainiae) 22, the Radix Stemonae 9, Semen Armeniacae Amarum 9, Radix Ginseng 3, Radix Ophiopogonis 15, Fructus Schisandrae Chinensis 5, Bulbus Fritillariae Uninbracteatae 9, the Rhizoma Anemarrhenae 12.
(2) preparation medical additive: take off and state raw material and mix and grind and be fine powder, be weight portion (every part of 5g): Moschus 0.06, Borneolum Syntheticum 0.2.
(3) preparation spray: medical additive is placed in the Chinese medicine extraction liquid mix homogeneously, and the consumption of medical additive is 1% of Chinese medicine extraction liquid weight, is aided with pharmaceutically acceptable carrier package and gets.
The preparation method of the Traditional Chinese medicinal aerosol of embodiment 4 treatment acute episode of cor pulmonale by combinations comprises step:
(1) preparation Chinese medicine extraction liquid: take off and state raw material and add 2000 parts, water, decocted 40 minutes, filtrate concentrates, be weight portion (every part of 25g): Semen Coicis 35, Rhizoma Phragmitis 35, Semen Persicae 10, Semen Benincasae 35, Pumex 35, Semen Trichosanthis 24, Semen Lepidii (Semen Descurainiae) 28, the Radix Stemonae 10, Semen Armeniacae Amarum 12, Radix Ginseng 5, Radix Ophiopogonis 20, Fructus Schisandrae Chinensis 8, Bulbus Fritillariae Uninbracteatae 10, the Rhizoma Anemarrhenae 15.
(2) preparation medical additive: take off and state raw material and mix and grind and be fine powder, be weight portion (every part of 25g): Moschus 0.04, Borneolum Syntheticum 0.1.
(3) preparation spray: medical additive is placed in the Chinese medicine extraction liquid mix homogeneously, and the consumption of medical additive is 1.8% of Chinese medicine extraction liquid weight, is aided with pharmaceutically acceptable carrier package and gets.
Model case: xxx, the women, 53 years old, the patient had the asthma medical history more than 30 year, often cough at ordinary times, and feel asthma, out of breath and feel suffocated.In January, 2006 unexpected sx↑, sweating due to debility is dripping, lower limbs edema, the green around the gills emergency treatment is rescued at local hospital, cardiac function level Four at that time, the Color Sonography prompting enlarges whole-heartedly, heart failure, lung A high pressure.Because the state of an illness is critical, local doctor informs that patient treatment wishes not quite.
For seeking better treatment, the patient began to take the Traditional Chinese medicinal aerosol of the present embodiment gained treatment acute episode of cor pulmonale by combination, 7 days courses for the treatment of in March, 2010.Took 21 days, precordialgia, cough alleviate, and fatigue and weak also alleviates, and the amount of receiving increases, spirit can, took 5 months, the blood supply of electrocardio diagram coronary artery obviously improves, continuing takes 12 months, the recovery from illness of patient's self-induction.
The preparation method of the Traditional Chinese medicinal aerosol of embodiment 5 treatment acute episode of cor pulmonale by combinations comprises step:
(1) preparation Chinese medicine extraction liquid: take off and state raw material and add 2000 parts, water, decocted 30 minutes, filtrate concentrates, be weight portion (every part of 10g): Semen Coicis 30, Rhizoma Phragmitis 30, Semen Persicae 9.5, Semen Benincasae 30, Pumex 30, Semen Trichosanthis 23, Semen Lepidii (Semen Descurainiae) 26, the Radix Stemonae 9.5, Semen Armeniacae Amarum 10, Radix Ginseng 4, Radix Ophiopogonis 18, Fructus Schisandrae Chinensis 6, Bulbus Fritillariae Uninbracteatae 9.5, the Rhizoma Anemarrhenae 13.
(2) preparation medical additive: take off and state raw material and mix and grind and be fine powder, be weight portion (every part of 10g): Moschus 0.05, Borneolum Syntheticum 0.15;
(3) preparation spray: medical additive is placed in the Chinese medicine extraction liquid mix homogeneously, and the consumption of medical additive is 1.5% of Chinese medicine extraction liquid weight, is aided with pharmaceutically acceptable carrier package and gets.
The clinical practice of the Traditional Chinese medicinal aerosol of test example 1 embodiment 5 gained treatments acute episode of cor pulmonale by combinations: in May, 2009-2011 year October, 4 second-rank first class hospital screening 120 routine patients with cor pulmonale, women's 62 examples wherein, male's 58 examples, oldest 75 years old, minimal ages 35 years old, 57.8 years old mean age.2 weeks before test, this crowd is carried out Continuous Observation, record symptom and variation, be divided at random two groups, experimental group and matched group, experimental group are taken embodiment 5 products obtained therefroms, and matched group is taken other medicine (the conventional medicines such as hydrochlorothiazide, metoprolol).Curative effect situation criterion: cure: take 3 courses for the treatment of of this product, cough obviously improves, and the blood supply of electrocardio diagram coronary artery obviously improves, and malaise symptoms disappears, and energy and muscle power obviously strengthen; Effectively: take 3 courses for the treatment of of this product, the cough sx↓, the chronic coronary artery blood supply of electrocardio diagram improves, and malaise symptoms alleviates or part disappears, and energy and muscle power strengthen; Invalid: take 3 courses for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 5 product 35-75 year pulmonary heart disease crowd therapeutic outcomes
Therapeutic effect: cure 70 examples (70%), effective 29 examples (29%), invalid 1 example (1%), total effective rate 99%.Successful is better than matched group.
During taking, self-induction symptom and physical change of spirit thereof are as shown in table 2.
Table 2:
The pulmonary heart disease delay is difficult, and during acute attack, relief of symptoms is most important as early as possible.The present invention is with a thousand pieces of gold weijing decoction (Chinese medicine decoction that is comprised of Rhizoma Phragmitis, Semen Coicis, melon lobe, Semen Persicae etc.Present multiplex Rhizoma Phragmitis replaces Rhizoma Phragmitis, and Semen Benincasae replaces the melon lobe.This medicine is usually used in the treatment of the diseases such as pulmonary abscess, lobar pneumonia, bronchitis, pertussis clinically) be source, with the Rhizoma Anemarrhenae, Bulbus Fritillariae Uninbracteatae, Pumex, Semen Trichosanthis removing heat from the lung and dissipating phlegm; Semen Lepidii (Semen Descurainiae), Semen Armeniacae Amarum, Radix Stemonae antiasthmatic-antitussive; Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis tonifying the lung yin fluid astringing, Qi-benefiting and heart-nourishing; Borneolum Syntheticum can be warded off and dirtyly have one's ideas straightened out.Produce synergism after making these drug regimens, can more effectively treat pulmonary heart disease and by its sequela that causes.Take 10s, feeling more than 52% takes a turn for the better to some extent; Took 50 days, feeling more than 75% takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Took 100 days, feeling more than 98% takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and the blood supply of electrocardio diagram coronary artery obviously improves, the recovery from illness of some patients were self-induction.Take in experimental group more than 100 days, effective percentage can reach more than 93%, and matched group mostly is 80% most.Traditional Chinese medicinal aerosol of the present invention gets final product produce effects after taking 10s, but matched group is not obvious.
The application's prescription is the distinguished veteran doctors of TCM proved recipe, and has passed through Liaocheng University, Liaocheng City experts and scholars' of the hospital of traditional Chinese hospital demonstration, has the prospect of industrialized implementation.The present inventor is the Shandong employee of the institute of political science and law (speaker's inventive science), and completing of this invention has benefited from Shandong Province's 12 Planning emphasis subjects---the support of Law of Economy subject fund.
Should be pointed out that the specific embodiment is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, and a lot of distortion can also be arranged.Those of ordinary skill in the art, with the present invention clear and definite disclosed or undoubted according to the written description of file obtaining, all should think the claimed scope of this patent.
Claims (7)
1. the preparation method of the Traditional Chinese medicinal aerosol for the treatment of acute episode of cor pulmonale by combination, is characterized in that, comprises step:
(1) preparation Chinese medicine extraction liquid: take off and state raw material and add water 1500-2200 part, decocted 20-45 minute, filtrate concentrates, be weight portion: Semen Coicis 20-45, Rhizoma Phragmitis 20-45, Semen Persicae 6-12, Semen Benincasae 20-45, Pumex 20-45, Semen Trichosanthis 20-26, Semen Lepidii (Semen Descurainiae) 20-30, Radix Stemonae 6-12, Semen Armeniacae Amarum 6-15, Radix Ginseng 2-6, Radix Ophiopogonis 12-25, Fructus Schisandrae Chinensis 3-9, Bulbus Fritillariae Uninbracteatae 6-12, Rhizoma Anemarrhenae 10-20;
(2) preparation medical additive: take off and state raw material and mix and grind and be fine powder, be weight portion: Moschus 0.02-0.08, Borneolum Syntheticum 0.05-0.3;
(3) preparation spray: medical additive is placed in the Chinese medicine extraction liquid mix homogeneously, and the consumption of medical additive is the 0.5-3% of Chinese medicine extraction liquid weight, is aided with pharmaceutically acceptable carrier package and gets.
2. preparation method as claimed in claim 1, is characterized in that, each raw material in step (1): Semen Coicis 25-35, Rhizoma Phragmitis 25-35, Semen Persicae 9-10, Semen Benincasae 25-35, Pumex 25-35, Semen Trichosanthis 22-24, Semen Lepidii (Semen Descurainiae) 22-28, Radix Stemonae 9-10, Semen Armeniacae Amarum 9-12, Radix Ginseng 3-5, Radix Ophiopogonis 15-20, Fructus Schisandrae Chinensis 5-8, Bulbus Fritillariae Uninbracteatae 9-10, Rhizoma Anemarrhenae 12-15.
3. preparation method as claimed in claim 2, is characterized in that, each raw material in step (1): Semen Coicis 30, Rhizoma Phragmitis 30, Semen Persicae 9.5, Semen Benincasae 30, Pumex 30, Semen Trichosanthis 23, Semen Lepidii (Semen Descurainiae) 26, the Radix Stemonae 9.5, Semen Armeniacae Amarum 10, Radix Ginseng 4, Radix Ophiopogonis 18, Fructus Schisandrae Chinensis 6, Bulbus Fritillariae Uninbracteatae 9.5, the Rhizoma Anemarrhenae 13.
4. preparation method as claimed in claim 1, is characterized in that, each raw material in step (2): Moschus 0.04-0.06, Borneolum Syntheticum 0.1-0.2.
5. preparation method as claimed in claim 4, is characterized in that, Moschus 0.05, Borneolum Syntheticum 0.15.
6. preparation method as claimed in claim 1, is characterized in that, in step (3), the consumption of medicinal additive is the 1-2% of Chinese medicine extraction liquid weight.
7. preparation method as claimed in claim 6, is characterized in that, the consumption of medical additive is 1.5% of Chinese medicine extraction liquid weight.
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