CN106822852A - Treat pharmaceutical composition, its preparation technology and the purposes of coronary heart disease - Google Patents

Treat pharmaceutical composition, its preparation technology and the purposes of coronary heart disease Download PDF

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CN106822852A
CN106822852A CN201710213215.5A CN201710213215A CN106822852A CN 106822852 A CN106822852 A CN 106822852A CN 201710213215 A CN201710213215 A CN 201710213215A CN 106822852 A CN106822852 A CN 106822852A
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heart disease
pharmaceutical composition
coronary heart
decoction
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康明
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Abstract

The invention belongs to the field of Chinese medicines, a kind of pharmaceutical composition for treating coronary heart disease is made up of following raw material：0.5~1 part of 60~220 parts of monkshood, 30~70 parts of rhizoma zingiberis, 30~60 parts of honey-fried licorice root, 20~40 parts of ginseng, 20~40 parts of keel, 20~40 parts of oyster, 15~30 parts of rhizoma nardostachyos, 20~40 parts of cassia twig, 70~150 parts of mountain cornel, 30~60 parts of jujube kernel, 6~9 parts of placenta, 6~10 parts of pseudo-ginseng, 10~15 parts of pilose antler and Moschus.Pharmaceutical composition of the present invention with monkshood, rhizoma zingiberis, ginseng as monarch's recuperating depleted yang, reinforce vital energy；Keel, oyster, mountain cornel, honey-fried licorice root are in the solid remove-subsidy of minister convergence；Spina date seed, cassia twig, rhizoma nardostachyos, pseudo-ginseng are activated yang the analgesic of multiple arteries and veins vital energy regualting and blood circulation-promoting for assistant；Xiang perfume, pilose antler, placenta mend essence to make inducing resuscitation of having one's ideas straightened out, promoting blood circulation and stopping pain, warm kidney.All medicine Synergistics, reach recuperating depleted yang, the work(of activate yang multiple arteries and veins, restoring normal coordination between heart and kidney eventually.

Description

Treat pharmaceutical composition, its preparation technology and the purposes of coronary heart disease
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of pharmaceutical composition for treating coronary heart disease, its preparation technology And purposes.
Background technology
" coronary heart disease ", is routinely interpreted as coronary atherosclerotic heart disease, is that coronary artery occurs artery congee Sample hardens lesion and causes lumen of vessels stenosis or occlusion, causes myocardial ischemia, anoxic or heart disease caused by necrosis.Coronary heart disease Actual covering scope may more extensively, also cause luminal stenosis or obturation etc. including inflammation, embolism etc..The World Health Organization will Coronary heart disease is divided into 5 major classes：Silent ischemia (latent coronary heart disease), angina pectoris, myocardial infarction, ischemic heart failure (ischemic heart disease) and 5 kinds of Clinical types of sudden death.Usually it is divided into SCHD and acute coronary syndromes in clinic Levy.
Coronary heart disease is one of most common disease of the elderly, serious influence health of people and life.Research according to investigations is tied Fruit shows, with the improvement of people's living standards, the morbidity and mortality of coronary heart disease are presented the trend for rising year by year, this value of being The serious problems that must be noted.Coronary heart disease is multiple to be born in after 40 years old, and male is more than women.Coronary heart disease can be caused by many factors , the people for having dyslipidemia is easier to suffer from coronary heart disease, particularly hypertension, diabetic population etc.；Coronary heart disease also has certain heredity Property；Physical exertion reduction, obesity, excessive drinking, edgy, high heat, high fat diet etc. all easily cause the generation of coronary heart disease.
Current medical field mainly includes following means for the treatment of coronary heart disease：1. chemotherapy：Antithrombotic (anti-blood Platelet, anti-freezing), mitigate myocardium keto consumption (beta-blocker), allevating angina pectoris (nitrate esters) adjust fat stabilization patch (Statins Fat regulation medicine)；2. surgical operation revascularization treatment：Including PCI (intravascular balloon expands plasty and Stent) With surgery CABG.Chemotherapy is many for relief of symptoms, and it is big that it is frequently accompanied by side effect It is not enough.The initiative treatment of surgical operation intervention, it is bigger to patient body legion, particularly with the coronary disease based on the elderly Patient, physical function metabolic capability is died down, and postoperative complications are easily produced, and post-operative recovery is slow, while surgical operation therapy High cost, and need the chemicals mate-assist Synergistic treatment of accompanied by long-term.On chemicals and surgical operation medicine, Coronary heart disease is treated jointly by the way of doctor trained in Western medicine circle is generally still be combined with each other using two kinds at present.
In order to solve foregoing problems, middle medical circles have also carried out continuous trial, number of patent application to the treatment of coronary heart disease 201510875928.9th, 201110175829.1,201510256092.4 and 201610392239.7 Chinese invention patent Application i.e. once disclose respectively " a kind of medicine for treating coronary heart disease, a kind of prescription for treating coronary heart disease, treatment coronary heart disease, Anginal pharmaceutical composition and the formula for controlling coronary heart disease ", it is secondary to expect to solve the somewhat expensive that foregoing coronary heart disease treatment is present Effect is big, the technical problem such as serious to body injury, makes some progress respectively, but still has many deficiencies, deficiency tool The aspects such as body surface present " therapeutic effect is poor, treatment cycle is long, raw material are rare is difficult to obtain ".
Based on foregoing discussion, existing treatment means and medicine for coronary heart disease, somewhat expensive, pair that generally existing is present Effect is big, therapeutic effect serious to body injury is poor, treatment cycle is long, raw material are rare the deficiency such as is difficult to obtain.
The content of the invention
In order to solve the above mentioned problem of prior art presence, the present invention provides a kind of pharmaceutical composition for treating coronary heart disease, It is excellent that the pharmaceutical composition of the treatment coronary heart disease that the present invention is provided has efficient height, treatment cycle is short, raw material are cheap and easy to get etc. Point, accordingly, the preparation technology of the pharmaceutical composition that the treatment coronary heart disease is also provided of the invention, and the treatment coronary heart disease Purposes of the pharmaceutical composition in the medicine for preparing the diseases such as treatment pulmonary emphysema and/or pulmonary heart disease.
The present invention is implemented by the following technical programs：
First, the present invention provides a kind of pharmaceutical composition for treating coronary heart disease, is mainly prepared by the raw material of following weight portion Form：
The patient lighter for the coronary heart disease state of an illness, the raw material composition of the pharmaceutical composition for the treatment of coronary heart disease of the invention can be made Hereinafter adjust, be mainly prepared from by the raw material of following weight portion：
The patient more serious for the coronary heart disease state of an illness, the raw material composition of the pharmaceutical composition for the treatment of coronary heart disease of the invention Following adjustment can be made, be mainly prepared from by the raw material of following weight portion：
A specific embodiment of the invention, the pharmaceutical composition for the treatment of coronary heart disease of the invention is by following weight portion Raw material be prepared from：
The raw material composition of the pharmaceutical composition based on foregoing treatment coronary heart disease of the invention, controls present invention also offers described The preparation technology of the pharmaceutical composition of coronary heart disease is treated, step is：
S1, placenta and pseudo-ginseng are weighed, placenta powder and Radix Notoginseng powder are obtained after grinding respectively, it is standby；
S2, Moschus is weighed, it is standby；
S3, monkshood is weighed, to adding the water of 600 weight portions to carry out first time decoction in monkshood, obtained after decocting for the first time Mixture is decocted for the first time；
S4, remaining all raw materials are weighed, in adding S3 gained to decoct mixture for the first time after crushing respectively, carried out second Decoct, it is standby to filter to take decoction liquor after second decoction；
S5, the placenta powder, Radix Notoginseng powder, Moschus and decoction liquor combine the medicine as the treatment coronary heart disease Composition.
The pharmaceutical composition of the treatment coronary heart disease obtained by preparation technology of the invention, when specifically used, coordinated and decocted Liquid is taken after mixing it with water placenta powder, Radix Notoginseng powder and Moschus.
In order to further lift drug effect, in foregoing preparation technology, the decocting time decocted for the first time described in S3 is excellent Elect 40min~60min as.The decocting time that second decocts described in S4 is preferably 20min~40min.Decocted for the second time in S4 When boiling, preferably first big fire is boiled, and then further preferably moderate heat is decocted.
According to embodiment and clinical effectiveness case that the present invention is provided, the present invention correspondingly provides medicine of the present invention Purposes of the compositions in the medicine for preparing treatment coronary heart disease, pulmonary emphysema and/or pulmonary heart disease.In the purposes, coronary heart disease bag Include but be not limited to angina pectoris, myocardial infarction and heart failure.The medicine includes any pharmaceutically acceptable formulation, including but not It is limited to pill, powder, oral liquid, tablet etc..
Monkshood, also known as the rhizome of Chinese monkshood or tag, alias：Radix aconiti agrestis, the salt rhizome of Chinese monkshood, E Erhua, the ornamental work of iron, the five poisonous creatures: scorpion, viper, centipede, house lizard, toad, Latin literary fame： Aconitum carmichaeli Debx. Ranunculaceaes, Aconitum.Monkshood have mends fire supporing yang, dispelling cold and dehumidification, recuperating depleted yang, only The effect of pain, cures mainly yang depletion and is intended to take off, cold weak pulse of limb, impotence Gong Leng, cold limbs headache, yin fire larynx numbness, trusted subordinate's crymodynia, vomiting and diarrhoea protracted dysentery, Cold junction constipation, cold sensation of the genitalia oedema, cold long-pending hernia lump in the abdomen, deficiency of yang diseases caused by external factors, wind-cold-dampness arthralgia, apoplexy contraction urgency, cloudy subcutaneous ulcer sore leakage.Monkshood band is toxic, Such as process that improper or dosage is excessive and decocting time not enough, can cause toxic reaction.
Rhizoma zingiberis, Chinese medicine name.It is the dry rhizome of zingiber Zingiber oj-jicinale Rosc..Rhizoma zingiberis taste It is pungent, property heat, returns spleen, stomach, kidney, the heart, lung channel, work(warming spleen and stomach for dispelling cold, Back to Yang Tongmai, Wenfei of drink are cured mainly for coldness and pain in the epigastrium, vomiting Diarrhea, cold weak pulse of limb, cold drink is breathed with cough.
Honey-fried licorice root, is pulse family glycyrrhiza genus, and Radix Glycyrrhizae has inhibitory action to the gastroxia that histamine causes；And have anti- Acid and the spasm effect of alleviation gastrointestinal smooth muscle.Radix Glycyrrhizae also has anti-inflammatory, and anti-allergic effects can protect the throat and tracheae of inflammation to glue Film.Extract of licorice root has the detoxication of similar glucuronic acid with glycyrrhizic acid to some poisonous substances.Radix Glycyrrhizae is commonly used to treatment with climacteric Phase and come symptom because Radix Glycyrrhizae in contain glycyrrhizin, be a kind of compound of similar hormone, it contribute to balance women body in Hormone-content.Hypo acid contained by Radix Glycyrrhizae can block the effect of Induced by Carcinogen tumour growth.
Ginseng, is herbaceos perennial, Araliaceae Panax, nature and flavor：Sweet, slight bitter, it is warm in nature, flat, returns spleen, lung channel, The heart channel of Hang-Shaoyin.Tonifying Qi, Gu it is de-, promote the production of body fluid, calm the nerves, intelligence development.Effect：Reinforce vital energy, veins takes off admittedly reinforces the spleen to benefit the lung, and promotes the production of body fluid, and calms the nerves.Ginseng Fleshy root be famous strong tonic, it is adaptable to adjust blood pressure, recover cardiac function, neurasthenia and the disease such as in poor health, Also there is the effects such as eliminating the phlegm, stomach invigorating, diuresis, excitement.Ginseng is cured mainly：Physically weak to be taken off, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung is breathed with cough, Tianjin Wound is thirsty, and Heat Diabetes, prolonged illness void is thin, insomnia of palpitating with fear, impotence Gong Leng；Heart failure, cardiogenic shock.For dyspnea with shortness of breath, Palpitation and amnesia, thirsty hidrosis, deficiency of food is powerless, all acute and chronic diseases and the shock caused after losing blood, collapse.Reinforce vital energy, Gu It is de- to promote the production of body fluid, calm the nerves.Control internal lesion caused by overexertion deficient, food is told in deficiency of food, burnout, gastric disorder causing nausea, lingering diarrhea of defecating, empty cough and asthma promotees, and spontaneous perspiration takes off cruelly, palpitation with fear is good for Forget, dizziness and headache, impotence, frequent micturition is quenched one's thirst, and woman uterine bleeding, children shy slowly, and not multiple, the card of all qi-blood-body fluid deficiencies empty long.
Keel, bone medicinal material, alias：Lu Hu loses life, that gal bone, Os Draconis, calcined Dragon's bone, five OS DRACONISs, green grass or young cropsization keel, flower Keel, white keel.It is sweet puckery, put down, enter the heart, liver, kidney, large intestine channel, indication：Transquilization with heavy material tranquillizing the mind by relieving convulsion, arrest sweating controlling nocturnal emission with astringent drugs, hemostasis Puckery intestines, myogenic sore.Control frightened epilepsy demented, palpitation is forgetful, insomnia and dreamful sleep, spontaneous sweating, stranguria with turbid discharge of passing out semen, hematemesis is had blood in stool, uterine bleeding band Under, rush down dysentery prolapse of the anus, ulcer does not close up long.
Oyster, Ostreidae oyster category.Oyster is rich in protein, zinc, the aliphatic acid of omega 3 and tyrosine, cholesterol level It is low.Wherein Zn content is high, helps improvement male's sexual.
Rhizoma nardostachyos, Chinese medicine name.Root and rhizome is dried for patrinia herb rhizoma nardostachyos Nardostachys jatamansi DC., Valerianaceae nard belongs to.Rhizoma nardostachyos taste is pungent, sweet, warm in nature, returns spleen, stomach, work(regulating qi-flowing for relieving pain, open it is strongly fragrant be amusing, external application clearing damp detumescence is main Control for abdominal fullness and distention, poor appetite, vomiting；Toothache, tinea pedis pyogenic infections are controlled in external application.
Cassia twig, alias：Liu Gui, Lauraceae Cinnamomum.Its nature and flavor acrid, sweet, warm, enters lung, the heart, bladder warp, is to cure mainly interior cold to commonly use Drugs for dispelling internal cold, the effect of with complement sun, promoting blood circulation, warming spleen and stomach, often with tonifying liver renal drug, fill blood medicine compatibility, treatment kidney yang is not Foot, the Yang-function insufficiency of kidneyzang, cold weak pulse of limb, with other drugs for dispelling internal cold compatibilities treatment coldness and pain in the epigastrium, arthritis pain in the back, ease pain and anti-with obvious The effect of cancer anti-cancer.Major function：Cassia twig energy sweating expelling pathogenic factors from muscles and skin, warming meridians and promoting circulation of qi, helps yang transforming qi, eliminating cold to stop pain.Main exterior syndrome due to wind-cold；It is cold Arthritis with fixed pain caused by dampness is bitterly；Peripheral coldness；Closed dysmenorrhea；Abdominal mass lumps；The obstruction of qi in the chest；Palpitaition；Phlegm and retained fluid；Difficult urination.For anemofrigid cold, gastral cavity abdomen is cold Bitterly, blood trembles with fear Amenorrhea, joint pain, phlegm and retained fluid, oedema, palpitaition, run quickly globefish.
Mountain cornel refers to Fructus Corni, Cornaceae Macrocarpium plant.Mountain cornel pulp is contained within 16 kinds of amino acid, in addition containing big Element necessary to amount human body.Contain physiologically active stronger saponin raw sugar, polysaccharide, malic acid, tartaric acid, phenols, tree in addition The composition such as fat, tannin and vitamin A, C.Its sour-puckery flavor, with nourishing, stomach invigorating, diuresis, filling liver kidney, the effects such as replenishing qi and blood.Cure mainly The diseases such as high blood pressure, soreness of waist and knee joint, dizziness and tinnitus, impotence and seminal emission, menorrhalgia.
Jujube kernel, namely jujube core, jujube nucleus, spina date seed, Rhamnaceae.Sweet, acid, mild-natured, effect nourishing the liver, calming heart is calmed the nerves, and is held back Sweat.With calmness, syngignoscism, stable effect and analgesia, cooling effect.
Placenta, Chinese medicine name, nature and flavor are sweet, salty, temperature, enter lung, the heart, kidney channel, there is tonifying kidney and benefiting sperm, the work(of nourishing qi and blood.
Pseudo-ginseng, Chinese medicine name.Sweet, slight bitter, temperature.Return liver, stomach.Work(dissipate stasis of blood hemostasis, detumescence ding-tong.Cure mainly for spitting blood, tell Blood, bleeding from five sense organs or subcutaneous tissue is had blood in stool, uterine bleeding, traumatism and bleeding, chest and abdomen shouting pain, tumbling and swelling.
Pilose antler, Chinese medicine name, in pilose antler containing phosphatide, glycolipid, glue fat, hormone, aliphatic acid, amino acid, protein and calcium, The compositions such as phosphorus, magnesium, sodium.
Moschus, Chinese medicine name, also known as very little fragrant, unit cun, MOSCHUS, smelly son, fragrant navel.Warm in nature, nontoxic, bitter.Enter the heart, spleen, Liver Channel, there is the function of having one's ideas straightened out, ward off dirty, dredging collateral, scattered silt.Apoplexy, coma due to blocking of the respiratory system, frightened epilepsy, middle evil unhappiness, trusted subordinate sudden and violent pain, bruise is cured mainly to damage Wound, swollen ulcer drug.
Based on discussed above, the beneficial effects of the invention are as follows：First, the drug regimen of the treatment coronary heart disease that the present invention is provided In thing, with monkshood, rhizoma zingiberis, ginseng as monarch's recuperating depleted yang, reinforce vital energy, cardiac stimulant；Keel, oyster, mountain cornel, honey-fried licorice root are restrained for minister Gu in remove-subsidy；Spina date seed, cassia twig, rhizoma nardostachyos, pseudo-ginseng are activated yang the analgesic of multiple arteries and veins vital energy regualting and blood circulation-promoting for assistant；Xiang perfume, pilose antler, placenta are to make to have one's ideas straightened out Inducing resuscitation, promoting blood circulation and stopping pain, benefiting essence-blood, warm kidney mend essence.All medicine collective effects, Synergistic is solid de-, logical up to recuperating depleted yang, convergence eventually Sun multiple arteries and veins, the work(of restoring normal coordination between heart and kidney.The pharmaceutical composition for the treatment of coronary heart disease of the invention is used for the treatment of clinical coronary heart disease, statistical number More than 85 percent is reached according to display overall clinical efficacy rate, meanwhile, pharmaceutical composition of the invention also has the treatment phase short, sees Effect is fast, the low advantage of cost of material.Secondly, the preparation technology of the pharmaceutical composition that the present invention is provided, extracts to greatest extent Medicinal ingredient in each raw material, while eliminate the toxicity of each raw material especially in monkshood, the poison for reducing finished product secondary is made With.Again, in further practical studies of the invention find, the present invention provide pharmaceutical composition also have treatment pulmonary emphysema and The effect of pulmonary heart disease, and curative effect stabilization, based on this, it is anticipated that, the pharmaceutical composition that the present invention is provided can not only be used Make to prepare the medicine for treating coronary heart disease, can be also used for making the medicine for the treatment of pulmonary emphysema and pulmonary heart disease.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical scheme will be carried out below Detailed description.Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Base Embodiment in the present invention, those of ordinary skill in the art are resulting on the premise of creative work is not made to be owned Other embodiment, belongs to the scope that the present invention is protected.
Technical scheme is further explained below in conjunction with specific embodiment and effect example.
Embodiment 1：
The present embodiment provides a kind of pharmaceutical composition, is prepared from the following materials：Monkshood 60g, rhizoma zingiberis 30g, honey-fried licorice root 30g, ginseng 20g, keel 20g, oyster 20g, rhizoma nardostachyos 15g, cassia twig 20g, mountain cornel 70g, jujube kernel 30g, placenta 6g, pseudo-ginseng 6g, deer Fine and soft 10g and Moschus 0.5g.
The specific preparation technology of the present embodiment is：Placenta and pseudo-ginseng are weighed, placenta powder and Radix Notoginseng powder are obtained after grinding respectively, It is standby.Moschus is weighed, it is standby.Monkshood is weighed, to adding the water of 600g to carry out first time decoction in monkshood, what is decocted for the first time decocts The time is boiled for 40min, obtains decocting mixture for the first time after decocting for the first time；Remaining all raw materials are weighed, is added after crushing respectively To enter decoct for the first time in mixture, carry out second decoction, second decocting time of decoction is 20min, after second decocts Filter to take decoction liquor standby.Gained placenta powder, Radix Notoginseng powder, Moschus and decoction liquor are combined and collectively constitute the present embodiment Pharmaceutical composition.
More specifically in case study on implementation, the pharmaceutical composition of the present embodiment can be used as preparing treatment coronary heart disease, pulmonary emphysema Or the medicine of pulmonary heart disease, the medicine can be respectively pill, powder, oral liquid or tablet.
Embodiment 2：
The present embodiment provides a kind of pharmaceutical composition, is prepared from the following materials：Monkshood 220g, rhizoma zingiberis 70g, honey-fried licorice root 60g, ginseng 40g, keel 40g, oyster 40g, rhizoma nardostachyos 30g, cassia twig 40g, mountain cornel 150g, jujube kernel 60g, placenta 9g, pseudo-ginseng 10g, Pilose antler 15g and Moschus 1g.
The specific preparation technology of the present embodiment is：Placenta and pseudo-ginseng are weighed, placenta powder and Radix Notoginseng powder are obtained after grinding respectively, It is standby.Moschus is weighed, it is standby.Monkshood is weighed, to adding the water of 600g to carry out first time decoction in monkshood, what is decocted for the first time decocts The time is boiled for 60min, obtains decocting mixture for the first time after decocting for the first time；Remaining all raw materials are weighed, is added after crushing respectively To enter decoct for the first time in mixture, carry out second decoction, during second decoction, first big fire is boiled, then moderate heat is decocted, second The decocting time of secondary decoction is 40min, and it is standby to filter to take decoction liquor after second decoction.Gained placenta powder, Radix Notoginseng powder, Moschus with And decoction liquor combines the pharmaceutical composition for collectively constituting the present embodiment.
More specifically in case study on implementation, the pharmaceutical composition of the present embodiment can be used as preparing treatment coronary heart disease, pulmonary emphysema Or the medicine of pulmonary heart disease, the medicine can be respectively pill, powder, oral liquid or tablet.
Embodiment 3：
The present embodiment provides a kind of pharmaceutical composition, is prepared from the following materials：Monkshood 120g, rhizoma zingiberis 50g, honey-fried licorice root 45g, ginseng 30g, keel 30g, oyster 30g, rhizoma nardostachyos 23g, cassia twig 30g, mountain cornel 110g, jujube kernel 45g, placenta 7.5g, pseudo-ginseng 8g, Pilose antler 12.5g and Moschus 0.8g.
The specific preparation technology of the present embodiment is：Placenta and pseudo-ginseng are weighed, placenta powder and Radix Notoginseng powder are obtained after grinding respectively, It is standby.Moschus is weighed, it is standby.Monkshood is weighed, to adding the water of 600g to carry out first time decoction in monkshood, what is decocted for the first time decocts The time is boiled for 50min, obtains decocting mixture for the first time after decocting for the first time；Remaining all raw materials are weighed, is added after crushing respectively To enter decoct for the first time in mixture, carry out second decoction, second decocting time of decoction is 30min, after second decocts Filter to take decoction liquor standby.Gained placenta powder, Radix Notoginseng powder, Moschus and decoction liquor are combined and collectively constitute the present embodiment Pharmaceutical composition.
More specifically in case study on implementation, the pharmaceutical composition of the present embodiment can be used as preparing treatment coronary heart disease, pulmonary emphysema Or the medicine of pulmonary heart disease, the medicine can be respectively pill, powder, oral liquid or tablet.
Embodiment 4：
The present embodiment provides a kind of pharmaceutical composition, is prepared from the following materials：Monkshood 90g, rhizoma zingiberis 50g, honey-fried licorice root 45g, ginseng 30g, keel 30g, oyster 30g, rhizoma nardostachyos 23g, cassia twig 30g, mountain cornel 110g, jujube kernel 45g, pseudo-ginseng 8g, pilose antler 12.5g With Moschus 0.8g.
The specific preparation technology of the present embodiment is：Pseudo-ginseng is weighed, Radix Notoginseng powder is obtained after grinding, it is standby.Moschus is weighed, it is standby With.Monkshood is weighed, to adding the water of 600g to carry out first time decoction in monkshood, the decocting time for decocting for the first time is 50min, the Obtain decocting mixture for the first time after once decocting；Remaining all raw materials are weighed, is added after crushing respectively and is decocted mixing for the first time In thing, second decoction is carried out, second decocting time of decoction is 30min, it is standby to filter to take decoction liquor after second decoction. Gained Radix Notoginseng powder, Moschus and decoction liquor combine the pharmaceutical composition for collectively constituting the present embodiment.
More specifically in case study on implementation, the pharmaceutical composition of the present embodiment can be used as preparing treatment coronary heart disease, pulmonary emphysema Or the medicine of pulmonary heart disease, the medicine can be respectively pill, powder, oral liquid or tablet.
Take the clinical reality of disease treatment that present invention 1~4 is respectively used to coronary heart disease, pulmonary emphysema and pulmonary heart disease Trample, achieve good therapeutic effect, specific medication takes mode for decoction liquor is taken after mixing it with water Radix Notoginseng powder, Moschus or placenta powder.
It is below the typical clinical therapeutic effect example of different embodiments：
Example 1：Lee, female 56 years old.Previously there are coronary disease and angina pectoris more than 6 years.In the recent period because precordialgia occurs in overwork Repeatedly, hospitalization, ONTG and the product for activating blood circulation and dispersing blood clots fail of the effect.Suggestion heart intervention treating, because its expense it is high Your patient is reluctant to receive, therefore looks for present inventor's diagnosis and treatment.Its complexion nigrescence, lip pastiness purple (during pain) and chilly are shown in sight Limb is cold, cold, stool weak all over send out dilute, clear abundant urine, the white fat big side of red tongue body tongue have indentation, deep thready pulse tight, and electrocardio is illustrated The T sections of change of ST mono-.Card category Yuanyang virtual loss, heart-yang deficiency, cold blood stasis, heart vessel blockage stasis, control with warming yang for dispelling cold, activate blood circulation and disperse blood clots, lead to The multiple arteries and veins of the heart.The pharmaceutical composition for taking the embodiment of the present invention 1 is treated.Its precordialgia good percentage after taking two doses 70, spirit is good, treated with three doses of 1 original side of embodiment again；Its percent more than 85 after taking three doses.For Consolidate curative effect, continued to strengthen with the original side of embodiment 1 and taken, 3 to 6 grams every time, 2 times a day take after mixing it with water, with trouble without offspring.The case diagnosis and treatment In, present inventor knows from experience：Coronary disease and angina pectoris , Huan Synopsis Golden Chambers》In be referred to as the obstruction of qi in the chest, its etiology and pathogenesis is summarized as " weak pulse at YANG and stringy pulse at YIN ".Zheng Qin'an is said：True unsaturated vapor, no matter in what portion, just gives birth to disease " (Huan doctor's method circles are logical volumes one》).First YANG deficiency Be the key for this disease, treatment should be helped based on sun, assistant with methods such as the promoting flow of qi and blood circulation, warm kidneys, treat both principal and secondary aspect of disease, curative effect can be improved.
Example 2：Sun, 78 years old, patient is diagnosed as after myocardial infarction hospitalization two weeks stable disease and leaves hospital.Because weather is prominent So turn cool and appearance shortness of breath uncomfortable in chest of overworking in addition, dripping cold sweat, shirtfront back squeezing sample pain, trick be ice-cold, weak pulse is intended to Wait disease absolutely, ECG T wave is still inverted, by after integrative therapy, the state of an illness is still unstable and has the gesture of progressive exacerbation.It is existing Symptoms include body it is thinner, Na Gu is not good, abdominal distension is just dilute, cold sweat, peripheral coldness, dynamic then sweating pectoralgia more very, wear plumageClothes are (just Value summer), spiritlessness and weakness, the dark violet neatly tongue of tongue, deep,thready and forceless pulse.Card category：Heart-kidney yang deficiency, yang-energy incite somebody to action exhausted card.Suddenly with Hui Yang Rescue the inverse, promoting blood circulation that activates yang, take off admittedly.Prepare the embodiment of the present invention 2 pharmaceutical composition simultaneously promptly decocted, taken, after half an hour its Sweating less, pain uncomfortable in chest subtract greatly, four limbs temperature, want that it is eusemia to eat, be, then give the pharmaceutical composition original side 2 of embodiment 2 Agent (monkshood be kept to 150 grams, remaining medicine it is constant), after taking 2 doses, appetite increase, walked with descending, shortness of breath good percentage 50 Above, recovery has been obviously improved with not cold, ECG T wave and last time contrast.Patient's great rejoicing, again with the medicine group of embodiment 2 5 times of compound original side amount, take after mixing it with water (6 grams every time, 2 times a day), with trouble without offspring.Next year sees it, such as ordinary person.In the case diagnosis and treatment, Present inventor's gains in depth of comprehension note：If the patient of old heart infarction, by treatment, the state of an illness still can not stablize, by Peng Ziyi (circle Move and Gu traditional Chinese medicine), it is that the center of circle is deviateed, yang-energy will be absolutely to be！Huan The Yellow Emperor's Canon of Internal Medicines》Say " patient with full stomach-QI being easy to treat and having a favorable prognosis, extreme hypofunction of the stomach are then dead ", therefore In treatment, occur wanting to eat be eusemia, this side with ginseng, monkshood, rhizoma zingiberis, honey-fried licorice root to repair the center of circle, to correct its inclined From, yin and yang in equilibrium, spirit or even.
Example 3：Wang, man, 63 years old.Suffer from pulmonary emphysema and pulmonary heart disease more than ten years it is remaining, recently because weather turn cold cough and expectoration more very, It is logical without smooth, Na Gu is good, tongue nature fresh water slides tongue plump tongue, arteries and veins that paroxysmal dyspnea and aversion to cold and cold limbs, urine occurs in night It is heavy trickle powerless.It is the card of obstruction of the lung by cold-phlegm, the heart insufficiency of both the spleen and the kindey to be.Take the pharmaceutical composition of the embodiment of the present invention 4, three doses of decoctings Clothes.Two examine：After taking three doses its more, chest of spitting feel comfortable, night can prostration, Na Gu it is good, not cold, then with Embodiment 15 doses of 4 original side decoction.Three examine：Had rosy cheeks during examining, sound is strong, 2 kilograms or so of increased weight, imitated not more Side, with the original side's quintuple of embodiment 4 powder is added to take after mixing it with water (one time 6 grams, 2 times a day) again, with after treatment.In the case diagnosis and treatment, Present inventor's gains in depth of comprehension note：Its curative effect is not good enough by western medical treatment for patient with pulmonary emphysema, pulmonary heart disease in clinic, past Toward by traditional Chinese medical science element culturing fixed folder, help that positive tonifying lung middle benefit gas are strong to superintend and direct method, evident in efficacy, and long-term effect is preferably, but must adhere to Enough courses for the treatment of (3 months to half a year).
Example 4：Slowly certain, man, 96 years old, suffer from chronic cardiac insufficiency and heart failure more than a year, aggravating to be in hospital recently gives oxygen uptake, strong The heart, diuresis and symptomatic treatment, after one week its state of an illness aggravated without alleviation, discharge of being critically ill, prepare funeral affairs.Household allows my diagnosis and treatment (still have a gleam of hope, with nearly its heart), hope its complexion pastiness, mouth Zhou Fazi, be short of breath, greasy hidrosis, gurgling with sputum, oxygen Not from its nose, hand it is cold cross elbow, foot it is cold cross knee, double lower limb oedema, be urinary and fecal inconvenience, tongue body is enlarged neatly, feeble and impalpable pulse.This is yang-energy Will be de-, critically ill, recuperating the depleted YANG to cure collapse-syndrome as emergency treatment of being eager, rouse oneself the sun of cardiopulmonary kidney.The pharmaceutical composition for preparing the embodiment of the present invention 3 is (former In material monkshood to adjust to 180g other constant) and promptly decocted, taken, second day examine it, its slightly fixed, urine discharge it is more, four Limb is not too cold, breathing is slightly put down, gurgling weith sputum subtracts greatly, no more side effects, then gives 2 doses of 3 original side of embodiment and be decocted in water for oral dose.Examine it within 4th： Its oedema disappeared half, gurgling weith sputum sound disappear, be eusemia (patient with full stomach-QI being easy to treat and having a favorable prognosis, extreme hypofunction of the stomach without exhaling oxygen again, one bowl of milled congee can be eaten being It is then dead), household's great rejoicing.Chinese yam 30g, fructus amomi 6g is added to mend the foundation of acquired constitution (taste) with the original side of embodiment 3 again.Five when examining, can Walk lowerly and see TV, then (two times a day, 6 grams every time) are taken after mixing it with water to consolidate curative effect with the original side's quintuple grinding of embodiment 3.Next year The daughter for seeing asks that his father is healthy no, its female say heart failure it is good but do physical examination find lung cancer, because known to patient, it is final because strongly fragrant Knot and it is dead！Unfortunately！
The above, specific embodiment only of the invention, but protection scope of the present invention is not limited thereto, and it is any Those familiar with the art the invention discloses technical scope in, change or replacement can be readily occurred in, should all contain Cover within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.

Claims (10)

1. a kind of pharmaceutical composition for treating coronary heart disease, it is characterised in that：Mainly it is prepared from by the raw material of following weight portion：
2. pharmaceutical composition according to claim 1, it is characterised in that：Mainly it is prepared from by the raw material of following weight portion：
3. pharmaceutical composition according to claim 1, it is characterised in that：Mainly it is prepared from by the raw material of following weight portion：
4. pharmaceutical composition according to claim 1, it is characterised in that：Mainly by the raw material preparation of following weight portion Into：
5. a kind of Claims 1 to 4 it is any it is described treatment coronary heart disease pharmaceutical composition preparation technology, it is characterised in that step It is rapid as follows：
S1, placenta and pseudo-ginseng are weighed, placenta powder and Radix Notoginseng powder are obtained after grinding respectively, it is standby；
S2, Moschus is weighed, it is standby；
S3, monkshood is weighed, to adding the water of 600 weight portions to carry out first time decoction in monkshood, first is obtained after decocting for the first time Secondary decoction mixture；
S4, remaining all raw materials are weighed, in adding S3 gained to decoct mixture for the first time after crushing respectively, carry out second and decoct Boil, it is standby to filter to take decoction liquor after second decoction；
S5, the placenta powder, Radix Notoginseng powder, Moschus and decoction liquor combine the drug regimen as the treatment coronary heart disease Thing.
6. preparation technology according to claim 5, it is characterised in that：The decocting time decocted for the first time described in S3 is 40min~60min.
7. preparation technology according to claim 5, it is characterised in that：The decocting time of second decoction is described in S4 20min~40min.
8. preparation technology according to claim 5, it is characterised in that：In S4 during second decoction, first big fire is boiled, then Moderate heat is decocted.
9. a kind of any described pharmaceutical composition of Claims 1 to 4 is preparing treatment coronary heart disease, pulmonary emphysema and/or pulmonary heart disease Purposes in medicine.
10. purposes according to claim 9, the coronary heart disease includes angina pectoris, myocardial infarction and heart failure.
CN201710213215.5A 2017-04-01 2017-04-01 Treat pharmaceutical composition, its preparation technology and the purposes of coronary heart disease Pending CN106822852A (en)

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* Cited by examiner, † Cited by third party
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CN107823625A (en) * 2017-12-18 2018-03-23 长春市中医院 A kind of traditional Chinese powder medicine for treating coronary heart disease myocardial infarction angina pectoris arrhythmia cordis heart failure

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Application publication date: 20170613