CN109700995B - A pharmaceutical composition for treating peptic ulcer, and its preparation method - Google Patents
A pharmaceutical composition for treating peptic ulcer, and its preparation method Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for treating peptic ulcer and a preparation method thereof, wherein the composition comprises the following raw materials: black monkshood, dried ginger, honey-fried licorice root, ginseng, bighead atractylodes rhizome, mangnolia officinalis, astragalus mongholicus, wrinkled gianthyssop, cuttle bone, trogopterus dung, cornu cervi degelatinatum, fish glue, pseudo-ginseng, thunberg fritillary bulb, aspongopus, wine-processed rhubarb and fructus evodiae. The medicine composition can effectively solve the pathogenesis and symptoms of the traditional Chinese medicine, is not easy to relapse, has no side effect after being taken, and embodies the core ideas of simplicity, convenience, low cost and natural law of traditional Chinese medicine.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for treating peptic ulcer and a preparation method thereof.
Background
Peptic ulcers are common in the stomach and duodenum and are named because ulcer formation is associated with gastric acid/pepsin digestion. The pathogenesis is as follows: 1. infection with helicobacter pylori. 2. Non-steroidal anti-inflammatory drugs are used. 3. Gastric acid and pepsin digest the mucosa itself. 4. Other factors (1. smoking. 2. inheritance. 3. acute stress. 4. gastroduodenal motility disorders); the clinical symptoms are as follows: epigastric pain is the main symptom, and may be dull pain, burning pain, distending pain, severe pain or hunger-like uncomfortable feeling, often accompanied by symptoms of acid regurgitation, belching, epigastric distention and the like. The most important are located in the middle and upper abdomen, which may be right or left. Generally, mild to moderate persistent pain. The pain is typical rhythmicity, and the gastric ulcer pain is relieved between two meals (hunger pain) and after eating; duodenal ulcer occurs about one hour after a meal, is relieved over 1-2 hours, and repeats the above rhythm until the next meal. Some patients experience pain at midnight (nighttime pain) and gastric ulcers are more common. Epigastric pain can be relieved after taking antacid; can be complicated with hemorrhage, perforation, pyloric obstruction, and canceration. The treatment is to inhibit gastric acid, maintain gastric mucosa, inhibit helicobacter pylori, stop non-steroidal anti-inflammatory drugs and perform surgical treatment.
The traditional Chinese medicine is treated by western medicines (ranitidine, sucralfate, omeprazole, clarithromycin and the like), but the western medicines have large side effects and are easy to relapse and only are used for symptomatic treatment; belongs to the category of stomachache in traditional Chinese medicine, and the pathogenesis of the stomachache is mainly caused by improper diet, maladjustment of cold and warmth, incoordination between liver and stomach, deficiency-cold of spleen and stomach and stagnation of qi and blood.
The present invention has been made in view of the above circumstances.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a pharmaceutical composition for treating peptic ulcer and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a pharmaceutical composition for treating peptic ulcer, comprising the following raw materials: black monkshood, dried ginger, honey-fried licorice root, ginseng, bighead atractylodes rhizome, mangnolia officinalis, astragalus mongholicus, wrinkled gianthyssop, cuttle bone, trogopterus dung, cornu cervi degelatinatum, fish glue, pseudo-ginseng, thunberg fritillary bulb, aspongopus, wine-processed rhubarb and fructus evodiae.
Further, the composition comprises the following raw materials in parts by weight: 60-90 parts of black monkshood, 25-45 parts of dried ginger, 20-30 parts of honey-fried licorice root, 18-30 parts of ginseng, 15-45 parts of bighead atractylodes rhizome, 18-35 parts of mangnolia officinalis, 60-150 parts of astragalus membranaceus, 25-30 parts of wrinkled gianthyssop herb, 15-30 parts of cuttle bone, 15-30 parts of trogopterus dung, 18-30 parts of cornu cervi degelatinatum, 15-30 parts of fish glue, 8-20 parts of pseudo-ginseng, 15-30 parts of thunberg fritillary bulb, 18-30 parts of aspongopus, 15-25 parts of wine-fried rhubarb and 15-45 parts of fructus evodiae.
Further, the composition comprises the following raw materials in parts by weight: 70-80 parts of black monkshood, 30-40 parts of dried ginger, 23-27 parts of honey-fried licorice root, 22-26 parts of ginseng, 25-35 parts of bighead atractylodes rhizome, 24-29 parts of mangnolia officinalis, 110 parts of astragalus membranaceus, 27-28 parts of wrinkled gianthyssop herb, 20-25 parts of cuttle bone, 20-25 parts of trogopterus dung, 22-26 parts of cornu cervi degelatinatum, 20-25 parts of fish glue, 12-16 parts of pseudo-ginseng, 20-25 parts of thunberg fritillary bulb, 22-26 parts of aspongopus, 18-22 parts of wine-fried rhubarb and 28-32 parts of fructus evodiae.
Further, the composition comprises the following raw materials in parts by weight: 75 parts of black monkshood, 35 parts of baked rhizoma zingiberis, 25 parts of honey-fried licorice root, 24 parts of ginseng, 30 parts of bighead atractylodes rhizome, 26.5 parts of mangnolia officinalis, 105 parts of astragalus membranaceus, 27.5 parts of wrinkled gianthyssop herb, 22.5 parts of cuttle bone, 22.5 parts of trogopterus dung, 24 parts of cornu cervi degelatinatum, 22.5 parts of fish glue, 14 parts of pseudo-ginseng, 22.5 parts of thunberg fritillary bulb, 24 parts of aspongopus, 20 parts of wine rhubarb and 30 parts of fructus evodiae.
The black monkshood is prepared by decocting raw monkshood with water for 1-3 hours and drying in the sun for later use. Black monkshood has the effects of restoring yang and rescuing collapse, and is used for treating yang exhaustion syndrome with symptoms of cold sweat, cold limbs and weak pulse. To tonify fire and strengthen yang, it is to tonify fire of the gate of life, which is yang of the kidney and yang of the body. Dispel cold to alleviate pain, it can warm the middle energizer and warm meridians.
The processed gan Jiang is mainly used for warming the middle energizer, restoring yang and promoting blood circulation, warming the middle energizer to dispel cold, warming the lung and resolving fluid retention. For the treatment of excessive cold drink intake, cold pathogen directly enters into body, and water flows in heavy rainy days, and cold pathogen enters from below.
Prepared licorice root, radix Glycyrrhizae Praeparata, has the main effects of regulating the middle warmer, relieving urgency, moistening lung, removing toxicity, and harmonizing the effects of the other drugs in the recipe. It is commonly indicated for weakness of spleen and stomach, lassitude, palpitation and intermittent pulse, and can relieve subsidiary toxicity.
A tonic medicine for regulating blood pressure, restoring cardiac function, treating neurasthenia and asthenia, and also has expectorant, stomach invigorating, diuretic and exciting effects.
Bighead atractylodes rhizome, rhizoma Atractylodis Macrocephalae, strengthens the spleen and nourishes qi, eliminates dampness and promotes diuresis, stops sweating and prevents abortion. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, and threatened abortion.
Hou Po Ku Wen dry dampness herb is used in damp obstruction of middle energizer, but its function is to promote qi circulation, which is more important than drying dampness, and its best classification should be qi-moving herbs, which have a synergistic relationship with the pale-rooted salvia root. The main part of qi circulation is the stomach and intestine, also including the lung meridian. The effect is mainly to relieve distension, eliminate abdominal distension or abdominal distension caused by qi stagnation, promote qi circulation and relieve distension most intensely, and all the symptoms are gastrointestinal qi stagnation and fullness regardless of cold, heat, deficiency and excess.
Radix astragali has effects in enhancing immunity, protecting liver, promoting urination, resisting aging, resisting stress, lowering blood pressure, and inhibiting bacteria. But excessive exterior pathogen, qi stagnation and dampness obstruction, food stagnation and stasis.
Huoxiang fragrant, resolving turbidity, regulating the middle warmer, arresting vomiting, relieving exterior syndrome and relieving summer-heat. Can be used for treating damp obstruction in middle warmer, abdominal distention, emesis, summer-heat dampness exterior syndrome, early stage of damp-warm syndrome, fever, listlessness, chest distress, cold-dampness, summer-heat, abdominal pain, emesis, diarrhea, nasosinusitis, and headache.
The cuttlefish bone is salty and astringent, but has mild property, has various efficacies of astringing to stop bleeding, securing essence and stopping leucorrhea, relieving pain, healing sore and the like, can be used for treating common diseases such as human hematemesis, hematochezia, kidney deficiency, stomachache, eczema and the like at ordinary times, and can be taken orally or externally used for treatment.
Wulingzhi has the functions of promoting blood circulation to disperse blood clots and stopping bleeding after being fried to charcoal. Can be used for treating pain due to blood stasis of heart and abdomen, dysmenorrhea, amenorrhea due to blood stasis, and puerperal abdominal pain due to blood stasis; charring to treat metrorrhagia and metrostaxis; it is used externally to treat traumatic injury, snake bite and insect bite.
Cornu Cervi Degelatinatum has effects of warming kidney, tonifying yang, astringing, and stopping bleeding. It is indicated for spleen-kidney yang deficiency, leukorrhagia, enuresis, frequent urination, metrorrhagia, metrostaxis, bleeding, unhealing sores and ulcers.
The fish glue has the functions of nourishing liver and kidney, nourishing blood, stopping bleeding, dissipating blood stasis and eliminating swelling. It is often used for treating spermatorrhea due to kidney deficiency, asthenia of waist and knees, lumbago, vertigo, tinnitus, leucorrhea, habitual abortion, blood deficiency, spasm of tendons, puerperal wind spasm, tetanus, epilepsy, aplastic anemia, hematemesis, hemoptysis, hematuria, metrorrhagia, traumatic hemorrhage, dorsal furuncle, fistula, chronic ulcer, rhagadia, gout, and hemorrhoid.
Notoginseng can dissipate blood stasis to stop bleeding, relieve swelling and alleviate pain. Can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic injury with swelling and pain.
Fritillaria thunbergii clears heat and reduces phlegm; dispel stagnation and dissipate nodulation.
Aspongopus regulates qi to alleviate pain, warms middle-jiao and invigorates yang. Can be used for treating stomach cold, distending pain, liver and stomach pain, kidney deficiency, sexual impotence, and soreness of waist and knees.
The wine-processed radix et rhizoma Rhei has effects of removing food stagnation, clearing away damp-heat, purging pathogenic fire, cooling blood, removing blood stasis, and removing toxic substance.
Evodia rutaecarpa, fructus evodiae is bitter and pungent in flavor and has the effects of dispelling cold, relieving pain, lowering adverse qi and arresting vomiting, and can be used for treating headache or epigastric pain caused by deficiency-cold of liver and stomach and adverse rising of yin-turbidity.
Further, the pharmaceutical composition further comprises pharmaceutically acceptable auxiliary materials or carriers, preferably pills, capsules or decoction.
A preparation method of the pharmaceutical composition for treating peptic ulcer comprises the following steps:
(1) weighing the raw materials according to the formula proportion, grinding the raw materials into fine powder respectively, and then uniformly mixing to obtain traditional Chinese medicine powder;
(2) the Chinese medicinal powder is added with medically acceptable auxiliary materials or carriers to prepare a medicament formulation.
Furthermore, the medicinal composition is a pill, and the auxiliary materials are raw powder and water.
Further, the diameter of the pill is 3-5 mm.
Further, the mass ratio of the traditional Chinese medicine powder to the raw powder to the water is 9-11:1-3:4-6, preferably 10:2: 5.
Further, the raw flour is potato flour, which can be purchased in the market, or the raw flour is sweet potato flour, rice flour and the like.
Further, the pharmaceutical composition is a capsule, and each capsule contains 0.75g of traditional Chinese medicine powder.
Wherein the shell of the capsule is prepared from commercially available raw materials.
Further, the composition of the invention is a decoction.
Further, the preparation method of the decoction comprises the steps of uniformly mixing the medicinal materials, adding 2200 parts by weight of 1800 plus materials of water, soaking for 35-45 minutes, boiling with strong fire for the first time, decocting for 35-45 minutes when adjusting the medium and small fire to obtain 220 parts by weight of the liquid medicine 180 plus materials, pouring out, adding 1100 parts by weight of the 900 plus materials of water into the dregs of a decoction, and decocting for 25-35 minutes to obtain 220 parts by weight of the liquid medicine 180 plus materials. Mixing the two decoctions, and respectively administering after breakfast and supper.
The decoction is administered in acute stage (with large effect due to strong force), and in remission stage and convalescent stage, the powder is prepared by grinding two to three times of the original formula, and has particle size of 80-100 mesh, 9g per time, and is administered with warm boiled water 2 times a day, and forty-nine days is a treatment course.
Compared with the prior art, the invention has the following beneficial effects:
the medicine composition can effectively solve the pathogeny, pathogenesis and symptom, is not easy to relapse, has no side effect after being taken, and embodies the core ideas of simple, convenient and cheap traditional Chinese medicine and natural law; the main action mechanism is that the black aconite, the baked rhizoma zingiberis and the evodia rutaecarpa have the effects of strengthening yang, warming middle-jiao and dispelling cold, the ginseng, the astragalus mongholicus and the bighead atractylodes rhizome have the effects of tonifying qi, tonifying spleen, supporting sore and promoting granulation, the magnolia officinalis, the aspongopus, the pseudo-ginseng, the baked licorice, the agastache rugosus and the wine-processed rhubarb have the effects of lowering qi, warming liver, harmonizing stomach, promoting blood circulation, removing blood stasis and relieving pain (the stomach is favored to be reduced and is new due to the fact that six fu organs are used for dredging), the trogopterus dung, the cuttle bone, the cornu cervi degelatinatum and the fish glue have the effects of warming stomach, relieving acidity.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
Example 1
A pharmaceutical composition for treating peptic ulcer, comprising the following raw materials: 60g of black monkshood, 25g of baked rhizoma zingiberis, 20g of honey-fried licorice root, 18g of ginseng, 15g of bighead atractylodes rhizome, 18g of mangnolia officinalis, 60g of astragalus, 25g of wrinkled gianthyssop herb, 15g of cuttle bone, 15g of trogopterus dung, 18g of cornu cervi degelatinatum, 15g of fish glue, 8g of pseudo-ginseng, 15g of thunberg fritillary bulb, 18g of aspongopus, 15g of wine-processed rhubarb and 15 g.
The pharmaceutical composition of the present example is a pill, and the preparation method is as follows:
(1) weighing the raw materials according to the formula proportion, grinding the raw materials into fine powder respectively, and then uniformly mixing to obtain traditional Chinese medicine powder;
(2) mixing the traditional Chinese medicine powder, potato powder and water according to the mass ratio of 10:2:5, and making into pills with the diameter of 4mm by a pill making machine, namely the pills.
Example 2
A pharmaceutical composition for treating peptic ulcer, comprising the following raw materials: 70g of black monkshood, 30g of baked rhizoma zingiberis, 23g of honey-fried licorice root, 22g of ginseng, 25g of bighead atractylodes rhizome, 24g of mangnolia officinalis, 100g of astragalus membranaceus, 27g of wrinkled gianthyssop herb, 20g of cuttle bone, 20g of trogopterus dung, 22g of cornu cervi degelatinatum, 20g of fish glue, 12g of pseudo-ginseng, 20g of thunberg fritillary bulb, 22g of aspongopus, 18g of wine-processed rhubarb and.
The pharmaceutical composition of the present example is a pill, and the preparation method is as follows:
(1) weighing the raw materials according to the formula proportion, grinding the raw materials into fine powder respectively, and then uniformly mixing to obtain traditional Chinese medicine powder;
(2) mixing the traditional Chinese medicine powder, potato powder and water according to the mass ratio of 9:1:4, and making into pills with the diameter of 5mm by a pill making machine, namely the pills.
Example 3
A pharmaceutical composition for treating peptic ulcer, comprising the following raw materials: 75g of black monkshood, 35g of baked rhizoma zingiberis, 25g of honey-fried licorice root, 24g of ginseng, 30g of bighead atractylodes rhizome, 26.5g of mangnolia officinalis, 105g of astragalus membranaceus, 27.5g of wrinkled gianthyssop herb, 22.5g of cuttle bone, 22.5g of trogopterus dung, 24g of cornu cervi degelatinatum, 22.5g of fish glue, 14g of pseudo-ginseng, 22.5g of thunberg fritillary bulb, 24g of aspongopus, 20g of wine-processed rhubarb.
The pharmaceutical composition of the present example is a pill, and the preparation method is as follows:
(1) weighing the raw materials according to the formula proportion, grinding the raw materials into fine powder respectively, and then uniformly mixing to obtain traditional Chinese medicine powder;
(2) mixing the traditional Chinese medicine powder, potato powder and water according to the mass ratio of 11:3:6, and making into pills with the diameter of 3mm by a pill making machine, namely the pills.
Example 4
A pharmaceutical composition for treating peptic ulcer, comprising the following raw materials: 80g of black monkshood, 40g of baked rhizoma zingiberis, 27g of honey-fried licorice root, 26g of ginseng, 35g of bighead atractylodes rhizome, 29g of mangnolia officinalis, 110g of astragalus, 28g of wrinkled gianthyssop herb, 25g of cuttle bone, 25g of trogopterus dung, 26g of cornu cervi degelatinatum, 25g of fish glue, 16g of pseudo-ginseng, 25g of thunberg fritillary bulb, 26g of aspongopus, 22g of wine-processed rhubarb and 32 g.
The pharmaceutical composition of this example is a capsule, and the preparation method is as follows:
(1) weighing the raw materials according to the formula proportion, grinding the raw materials into fine powder respectively, and then uniformly mixing to obtain traditional Chinese medicine powder;
(2) the traditional Chinese medicine powder is filled into a capsule shell, and each capsule contains 0.75g of the traditional Chinese medicine powder.
Example 5
A pharmaceutical composition for treating peptic ulcer, comprising the following raw materials: 90g of black monkshood, 45g of baked rhizoma zingiberis, 30g of honey-fried licorice root, 30g of ginseng, 45g of bighead atractylodes rhizome, 35g of mangnolia officinalis, 150g of astragalus, 30g of wrinkled gianthyssop herb, 30g of cuttle bone, 30g of trogopterus dung, 30g of cornu cervi degelatinatum, 30g of fish glue, 20g of pseudo-ginseng, 30g of thunberg fritillary bulb, 30g of aspongopus, 25g of wine-treated rhubarb and 45 g.
The pharmaceutical composition of the embodiment is a decoction, and the preparation method comprises the following steps:
mixing the medicinal materials uniformly, adding 2000g of water to soak for 40 minutes, then boiling with strong fire for the first time, decocting for 40 minutes while adjusting the medium and small fire to obtain 200g of liquid medicine, pouring out, adding 1000g of water to the dregs of a decoction for 30 minutes to obtain 200g of liquid medicine, and mixing the liquid medicines obtained by decocting twice to obtain the decoction.
Test example 1
When the male, plum and 42 years old suffer from discomfort in the stomach and hidden pain in the gastric cavity after eating every time, the pain is relieved after oral administration of omeprazole and bismuth pectin, and the male, plum and male suffer from severe stomach pain, hematemesis and stool due to the fact that the same students have a tendency to be greasy and drink, and go to a gastroscope in hospitals: gastroduodenal ulcer is treated according to symptoms and antacid and protects gastric mucosa, symptoms are improved after one week, stomachache, vomit and hematochezia appear after half a year due to improper qi generation in diets and drinking, the oral antacid and gastric mucosa protection drug has poor curative effect, gastric cavity is cold, hands and feet are cold, hypodynamia, acid regurgitation and dry stool are rare, and diagnosis and treatment are carried out before the admiration: it is also due to deficiency-cold of spleen and stomach, insufficiency of middle-jiao yang, and stagnation of qi and blood: for treatment, it can strengthen yang, warm middle energizer, regulate qi, activate blood, relieve hyperacidity and alleviate pain. The decoction prepared in example 5 was administered for treatment. The follow-up diagnosis comprises the following steps: after taking the above three preparations, the stomach pain is greatly reduced, the amount of passing qi (exhaust gas) is more, the hands and feet are warm without acid regurgitation, the stool is more, the whole body feels light and quick, and the patients are inconvenient to take the decoction for business trip and are ground into capsules by two times of the original prescription, three capsules are taken once and three times a day. (avoid drinking, overfull and cold food), and can be cured after half a year with follow-up visits and notices.
Test example 2
Liu somewhere, woman, 32 years old, peacefully love vitality, temporal feeling stomach discomfort, love eating the thing of ice cream and cold drink again, summer is hot, in order to relieve its heat, eat five root ice cream, even after stomach ache is very strong, profuse sweat is dribbling, vomit and accompany coffee thing, go to hospital emergency call, give and alleviate pain and symptomatic treatment, the symptom can be alleviated, do the gastroscopy after: stomach erosion is accompanied by ulcer soup, other oral western medicines are used for treating the stomach erosion, and patients are reluctant to diagnose and treat the stomach erosion (because the family members have peptic ulcer medical history, the oral western medicines have large side effects and are repeatedly attacked and difficult to cure): inspecting the sallow complexion (caused by chronic bleeding and poor nutrition absorption due to peptic ulcer), speaking with little breath and no speaking desire, wearing thicker clothes in summer (not feeling hot), pale, swollen and large tongue with teeth marks, deep, thready, weak and weak six pulses. This disease is caused by improper diet to impair middle-jiao yang, so that the transportation and transformation functions are firstly regulated and qi and blood are transformed and exhausted. Treatment was given as three doses of the decoction of example 5. In the case of a return visit, the patient can wear half sleeves and the stomach is suitable and the complexion is gradually good, so that the chronic disease needs to be cured for a long time, and then the pill of the example 2 is taken three grams each time and three times a day, and the patient suffers from the chronic disease after two months. After half a year, the doll meets and judges two people on the road, the color of the doll is red and the doll is strong, and after the doll is informed, the doll generates less qi and eats less cold drink to avoid relapse.
Example 3
Zhangyi, women and 68 years old, who suffer from arthritis for more than ten years, take analgesic and hormone drugs every oral administration to maintain symptoms, but in the last two years, the stomach pain is worse, and the patient feels burning after acid regurgitation of the sternum (caused by taking the analgesic and the hormone). Gastroscopy: reflux esophagitis and gastroduodenal ulcer, diagnosis and treatment: it is expected to have a dark complexion, swollen and painful joints, hiccups, a fishy smell in the mouth, slippery tongue with teeth marks, bluish purple teeth, and a deep left guan-string thin Tiangen pulse. The disease is caused by senile body weakness, insufficiency of yang-qi, cold evil entering the interior and western medicines orally taken to injure the middle and soil. Treating the disease; strengthen yang and warm the middle warmer, dispel cold to alleviate pain, promote blood circulation to remove blood stasis, regulate qi and harmonize stomach. The decoction in the embodiment 5 is used for treatment, the stomach pain and the acid regurgitation are slightly better (the stomach pain and the lower yang are too deficient) after the five doses are taken, and the traditional prescription is used for treatment by increasing the dosage of three doses; after the three diagnoses, the symptoms are greatly improved, and the pain of joints of the limbs is also relieved (the limbs are favorable due to the nine-cold spleen governing the limbs and the vigorous spleen caused by ten diseases), and the cold in the family environment is particularly ground into powder in three times of the formula, and 9g of the powder is taken with water twice a day each time. After one year, the children have been treated and reported that the old has been cured (can drink the food and can save pain for a large part).
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (9)
1. The pharmaceutical composition for treating peptic ulcer is characterized by comprising the following raw materials in parts by weight: 60-90 parts of black monkshood, 25-45 parts of dried ginger, 20-30 parts of honey-fried licorice root, 18-30 parts of ginseng, 15-45 parts of bighead atractylodes rhizome, 18-35 parts of mangnolia officinalis, 60-150 parts of astragalus membranaceus, 25-30 parts of wrinkled gianthyssop herb, 15-30 parts of cuttle bone, 15-30 parts of trogopterus dung, 18-30 parts of cornu cervi degelatinatum, 15-30 parts of fish glue, 8-20 parts of pseudo-ginseng, 15-30 parts of thunberg fritillary bulb, 18-30 parts of aspongopus, 15-25 parts of wine-fried rhubarb and 15-45 parts of fructus evodiae.
2. The pharmaceutical composition for treating peptic ulcer according to claim 1, wherein the composition comprises the following raw materials in parts by weight: 70-80 parts of black monkshood, 30-40 parts of dried ginger, 23-27 parts of honey-fried licorice root, 22-26 parts of ginseng, 25-35 parts of bighead atractylodes rhizome, 24-29 parts of mangnolia officinalis, 110 parts of astragalus membranaceus, 27-28 parts of wrinkled gianthyssop herb, 20-25 parts of cuttle bone, 20-25 parts of trogopterus dung, 22-26 parts of cornu cervi degelatinatum, 20-25 parts of fish glue, 12-16 parts of pseudo-ginseng, 20-25 parts of thunberg fritillary bulb, 22-26 parts of aspongopus, 18-22 parts of wine-fried rhubarb and 28-32 parts of fructus evodiae.
3. The pharmaceutical composition for treating peptic ulcer according to claim 1, wherein the composition comprises the following raw materials in parts by weight: 75 parts of black monkshood, 35 parts of baked rhizoma zingiberis, 25 parts of honey-fried licorice root, 24 parts of ginseng, 30 parts of bighead atractylodes rhizome, 26.5 parts of mangnolia officinalis, 105 parts of astragalus membranaceus, 27.5 parts of wrinkled gianthyssop herb, 22.5 parts of cuttle bone, 22.5 parts of trogopterus dung, 24 parts of cornu cervi degelatinatum, 22.5 parts of fish glue, 14 parts of pseudo-ginseng, 22.5 parts of thunberg fritillary bulb, 24 parts of aspongopus, 20 parts of wine rhubarb and 30 parts of fructus evodiae.
4. The pharmaceutical composition for treating peptic ulcer according to any one of claims 1 to 3, wherein said pharmaceutical composition further comprises pharmaceutically acceptable excipients.
5. A method for preparing a pharmaceutical composition for treating peptic ulcer according to any one of claims 1 to 4, comprising the steps of:
(1) weighing the raw materials according to the formula proportion, grinding the raw materials into fine powder respectively, and then uniformly mixing to obtain traditional Chinese medicine powder;
(2) the Chinese medicine powder is added with medically acceptable auxiliary materials to prepare the medicine.
6. The method for preparing a pharmaceutical composition for treating peptic ulcer according to claim 5, wherein the pharmaceutical composition is a pill and the excipients are raw powder and water.
7. The method for preparing a pharmaceutical composition for the treatment of peptic ulcer according to claim 6, wherein the diameter of the pill is 3-5 mm.
8. The method for preparing a pharmaceutical composition for the treatment of peptic ulcer according to claim 6 or 7, wherein the mass ratio of the Chinese medicinal powder, the raw powder and the water is 9-11:1-3: 4-6.
9. The method for preparing a pharmaceutical composition for treating peptic ulcer according to claim 5, wherein the pharmaceutical composition is in the form of capsule, and each capsule contains 0.75g of Chinese medicinal powder.
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| CN104758878A (en) * | 2015-03-18 | 2015-07-08 | 覃慧璇 | Traditional Chinese medicine composition for treating gastroduodenal ulcer in the type of cold evil invading stomach |
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