CN105582428A - Transdermal patch for acupoint sticking therapy and preparation method thereof - Google Patents
Transdermal patch for acupoint sticking therapy and preparation method thereof Download PDFInfo
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- CN105582428A CN105582428A CN201410818806.1A CN201410818806A CN105582428A CN 105582428 A CN105582428 A CN 105582428A CN 201410818806 A CN201410818806 A CN 201410818806A CN 105582428 A CN105582428 A CN 105582428A
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Abstract
The invention provides a transdermal patch for acupoint sticking therapy and a preparation method thereof. The patch comprises medicine and auxiliaries, the main component of the medicine is Ruyi anti-asthma powder, the weight ratio of the medicine to the auxiliaries is 1:(0.5-4), the auxiliaries are preferably azone, propylene glycol and vaseline, the total effective rate of the transdermal patch prepared through a certain process can reach 94% when the transdermal patch is used for treating cough and asthma in an attachment mode in clinical experiments, and remarkable significance is achieved.
Description
Technical field
The present invention relates to a kind of transdermal patch, especially relate to a kind of transdermal patch for acupoint application treatment and preparation method thereof, belong to external application field of medicine preparations.
Background technology
Point-application is to come dredging the channel, recuperating qi-blood by stimulating acupoint, by Chinese medicine, the stimulation of skin acupuncture points on the human body is brought into play to the integrally-regulated effect of channel system and YIN and YANG balance regulating, strengthening vital QI to eliminate pathogenic factors, dredging the channel, reaches the object for the treatment of.
One, traditional Chinese medical science idea:
Point application therapy, under instruction of Chinese Medicine theory, taking Chinese medicine meridian theory as theoretical foundation, select some certain drug, with medium (as water, vinegar, wine, honey, vegetable oil, liquid, saliva even) furnishing pasty state, or make ointment, pill or medicinal cake with being the grease (as vaseline etc.) that solidifies shape, or traditional Chinese herbal decoction is boiled into cream, or medicine end is spread on plaster, more directly stick acupuncture point, affected part (Ashi Point), the one that is used for treating disease is without traumatic pain acupoint therapy. See that from the science of acupuncture and moxibustion angle point application therapy belongs to the extension of moxibustion therapy, the irritant and fragrant medicine of walking to alter characteristic of multiselect apparatus, has certain " vesiculation therapy " feature. Be usually used in the disease of the aspects such as chronic cough is breathed heavily for a long time, diarrhoea, bi Zheng, larynx Dumb disease, aphtha, infantile enuresis. Point application therapy is the Typical Representative of external treatment of traditional Chinese medicine, has conveniently, imitates the features such as good, inexpensive, side effect is little. The Wu Shi of Qing Dynasty machine---" though control outside not different from controlling also interior. So parallel with internal therapy, and the too late person who controls in mending, this also ". The well-known doctor of the Qing Dynasty " medical science source and course opinion " author's Xu Dachun point out " it is sick to the greatest extent that decoction of medicinal ingredients is not enough, and people's disease, in entering outward; it is popular in channels and collaterals internal organs, and must take medicine is to drive it, if it sick existingly determine institute; between skin muscles and bones can by and person; with patch it, inaccessible its gas, makes the property of medicine enter its space between skin and muscles from pore; to stimulate the menstrual flow and pass through network; or carry it, or attack and loose it, take medicine especially effectively "
Theoretical foundation:
1, reason with in control: sick enter from outward, by expressing, have outer controlling to answer it, get outside it. Sick by interior life, shape all in outside, going from the interior to the exterior, can also control outward. Application therapy arrives the vital organs of the human body and four limbs bones of the body collectively by channels and collaterals, brings into play its therapeutic action. " reason of controlling outward, the reason of controlling in. "
2, medicine with in control: no matter for oral administration and point application, selected medicine all have unique separately four natures and five flavors of drug, effect return through with the attribute such as lifting sink-float, combine with dispeling disease and evil by monarch, minister, the mutual compatibility helping, make. But stick medication and often add fragrance, dripping of irritant drugs.
3, the medicine of applying ointment or plaster is often walked once controlling a disease incessantly with medicine, with multi-flavor medicine converge and collect it, rule multiple disease with a cream, though disease has multiple, its interpretation of the cause, onset and process of an illness not outer qi stagnation hemagglutination and the moon has cold-dampness, and sun has scorching, key is to hold its key, and hold the method at key, available " leading to " word is summarized, " reason general rule is controlled from logical ".
Two, the understanding of modern medicine to transdermal
Transdermal technology, is called again Transcutaneous Therapeutic System, refers to that medicine brings into play a class controlled release preparation of general action by skin with certain speed. Three kinds of approach that drug main will pass through absorb: 1, cuticula (mainly). 2, hair follicle, sebaceous glands. 3, sweat pipe. The skin the superiors are cuticula (by dead cellularities), and cuticula is solid closely, can effectively prevent the intrusion of bacterium, harmful chemical and pathogen. On cuticular surface, the film that also has one deck to be formed by lipid and other material. So skin has impermeability, it both can prevent that moisture from soaking into, and also can prevent the loss of moisture in body. So want effectively cooperative drug to see through cuticula for the selection of transdermal patch, medicine is arrived in body, reach the effect of controlled release. Existing market is used transdermal patch of a great variety, as azone, propane diols, oleic acid etc.
So effectively apply ancients' experience, in conjunction with modern pharmacology, pharmacokinetics, anatomical knowledge, can greatly improve point-application curative effect, and avoid taking medicine, pain and other discomforts that intramuscular injection and intravenous injection bring.
Cough, breathe heavily, the common sympton of the lung pattern disease such as phlegm is acute/chronic bronchitis, pneumonia, Mao Zhiyan, western medicine taking anti-inflammatory, antiviral, antibacterial, antiallergy, reduce phlegm, the treatment such as antibechic is as main, Chinese medicine adopts and eliminates the phlegm, diffusing lung, relieving exterior syndrome equality therapeutic modality. Because Western medicine side effect is larger, the dialectical trouble of Chinese medicine, medication difficulty.
Heating paresthesia cause of disease complexity, all kinds of infection all can cause this symptom, and common heating generally causes by the infection of the upper respiratory tract, and it is main that common therapeutic modality Western medicine adopts the agent of nonsteroidal antipyretic-antalgic, and necessary combination with glucocorticoids is used; Chinese medicine is taking clearing heat and detoxicating, loose the trembling with fear as main of inducing sweat.
Baby diarrhea reason is more, as common rotavirus enteritis, protein metabolism disorder cause etc., also has bacillary enteritis, chronic colitis etc. Mostly therapeutic modality is taking antibacterial, antiviral, fluid infusion, inducing astrigency antidiarrheal etc. as main.
For pediatric patient, oral injections difficult do not say, long term administration meeting brings liver kidney, nervous system, immune damage to children's. So, the technological deficiency that the present invention need to solve be how to utilize traditional point application therapy and modern transdermal technology to children's cough, breathe heavily, the symptom such as phlegm, diarrhoea and heating treats.
Summary of the invention
The object of the invention is to traditional acupoint application of Chinese herb therapy to combine with modern transdermal technology, can treat and cough the transdermal patch of breathing heavily by the mode of point-application so that the prescription Chinese medicine of the Dingchuan that complies with one's wishes is a kind of as main medication composition is prepared into.
The present invention also aims to provide a kind of preparation method of the transdermal patch for acupoint application treatment.
The constituent of transdermal patch Chinese traditional medicine of the present invention is mainly the Dingchuan powder as one wishes that 21 taste medicinal materials in Dingchuan prescription as one wishes are made, and remaining is auxiliary material, and the weight ratio of wherein comply with one's wishes Dingchuan powder and auxiliary material is 1:2～4, preferably 1:3.
The constituent of the medicine during transdermal patch one of the present invention pastes can also be comply with one's wishes Dingchuan powder 1～3g, Chinese ephedra 1g, root of Chinese wild ginger 1g, ambroxol 60mg, wherein the weight ratio of auxiliary material and medicine is 3:1, recombinant clam white injection 1ml, is used for the treatment of the disease of cough and asthma of chill class.
Ingredients composition during transdermal patch one of the present invention pastes can also be comply with one's wishes Dingchuan powder 1～3g, rheum officinale 1g, saltcake 1g, ambroxol 60mg, wherein the weight ratio of auxiliary material and medicine is 3:1, recombinant clam white injection 1ml, is used for the treatment of the disease of cough and asthma of wind-heat class.
Auxiliary material of the present invention is one or more in azone, propane diols, oleic acid, menthol, salicylic acid, vaseline, further, and preferably one or more in azone, propane diols, vaseline.
The prescription composition of Dingchuan powder as one wishes of the present invention is:
Gekko 150g, the dried venom of toads (system) 9g, Radix Astragali 500g, earthworm 500g, Chinese ephedra 500g, Radix Codonopsis 500g, semen armeniacae amarae 800g, gingko 500g, dried immature fruit of citron orange 300g, asparagus fern 400g, the fruit of Chinese magnoliavine (wine steaming) 500g, the tuber of dwarf lilyturf 400g, aster 400g, tuber of stemona 200g, fruit of Chinese wolfberry 300g, prepared rhizome of rehmannia 500g, polygala root 200g, lepidium seed 200g, datura flower 200g, gypsum 200g, Radix Glycyrrhizae (honey is processed) 500g
The preparation method of transdermal patch of the present invention is:
(1) by the semen armeniacae amarae of recipe quantity, put in boiling water and decoct, filter, obtain semen armeniacae amarae extract;
(2) get earthworm, Radix Codonopsis, gingko, asparagus fern, kadsura longepedunculata, the tuber of dwarf lilyturf, aster, the tuber of stemona, the fruit of Chinese wolfberry, prepared rhizome of rehmannia, polygala root, lepidium seed, partly measure the Radix Astragali, partly measure Radix Glycyrrhizae, after pulverizing, boiling 2～3 times, each decocting time is 1～3 hour, each amount of water is 6～8 times of above-mentioned dry medicinal material total amount, filter, merge extract;
(3) the semen armeniacae amarae extract in step (1) is mixed with the extract in step (2), being concentrated into relative density is the thick paste of more than 1.30 (70～80 DEG C of surveys);
(4) get the dried venom of toads, gekko, Chinese ephedra, the dried immature fruit of citron orange, datura flower, gypsum, partly measure the Radix Astragali, partly measure Radix Glycyrrhizae and pulverize respectively, after each Chinese medicine fine powder is mixed, carry out moist heat sterilization, mix with the thick paste obtaining in step (3), carry out wet granulation, cross 100 mesh sieves, obtain particle;
(5), after the particle obtaining in step (4) is pulverized, cross 10～100 mesh sieves, sterilizing, dry, be distributed into every bag of 1～3g, the Dingchuan that must comply with one's wishes powder.
(6) prepare the preparation method of 1 note: get 1 bag, the packed Dingchuan powder as one wishes that obtains in step (5), be equipped with pharmaceutically feasible auxiliary material, after mixing well, tear the easy tear tape of paster top, ointment is evenly spread upon to the oval-shaped groove place of special paster central authorities, then transdermal patch is affixed on to corresponding acupuncture point place, the heat producing after contacting with air by chemical heat layer is accelerated the Transdermal absorption of medicine; Patch size is that 5 × 7cm or 4 × 6cm are more suitable.
The preparation method of transdermal patch of the present invention, the acupuncture point described in step (6) is fei shu cave or SHANZHONG acupoint.
The preparation method of transdermal patch of the present invention, the chemical heat layer described in step (6) is grouped into by one-tenth such as vermiculite, activated carbon, salt, iron powders.
The present inventor also finds Dingchuan powder as one wishes of the present invention and the wind-weed, indigo naturalis, borneol on the basis of transdermal patch of the present invention, mulberry leaf-ginger common cold parenteral solution combines in addition auxiliary material of the present invention and makes transdermal patch, is affixed on big vertebra and/or SHENQUE acupoint treatment heating paresthesia has significant curative effect;
Wherein, the ingredients composition that described transdermal patch one pastes is: comply with one's wishes Dingchuan powder 1～3g, paracetamol 0.6g, wind-weed 1g, indigo naturalis 0.5g, borneol 0.3g, mulberry leaf-ginger common cold parenteral solution 1ml.
The present inventor also finds that on the basis of transdermal patch of the present invention Dingchuan powder as one wishes of the present invention and cloves, Chinese cassia tree, evodia rutaecarpa, the coptis, Cimetidine are combined in addition auxiliary material of the present invention makes transdermal patch, be affixed on SHENQUE acupoint and can treat the baby diarrhea of outbreak repeatedly, add and be attached to ZHONGWAN acupoint if any symptoms of emesis, there is significant curative effect;
Wherein, the ingredients composition that described transdermal patch one pastes is: Dingchuan powder 1～3g, cloves 1g, Chinese cassia tree 2g, evodia rutaecarpa 1g, coptis 1g, Cimetidine 0.8g comply with one's wishes.
Main component using 21 taste medicinal materials in the prescription of Dingchuan as one wishes of the present invention as transdermal patch, wherein the Dingchuan powder as one wishes of preparation is because being that most medicinal material is extracted to concentrated being prepared from, so more easily pass through Transdermal absorption; The datura flower of secondly, complying with one's wishes in Dingchuan prescription has the effect of chafe cuticula; The root of Chinese wild ginger, Chinese ephedra have good fragrance to walk to alter effect; The dried immature fruit of citron orange, earthworm, the dried venom of toads have the effect of stimulating the menstrual flow of good relieving stagnant Qi, can play the effect of stimulating Qi of meridian operation.
So transdermal patch of the present invention is attached on corresponding acupuncture point, make the integrally-regulated effect of channel system and YIN and YANG balance regulating, strengthening vital QI to eliminate pathogenic factors, dredging the channel by Chinese medicine stimulating acupoint, simultaneously by transdermal patch chafe cuticula, make effective ingredient enter hematological system, under the double action of stimulating acupoint and Drug Percutaneous Absorption, reach the object for the treatment of disease, clinical diagnosis is evident in efficacy, has clinical meaning.
The 21 taste medicinal materials of complying with one's wishes in Dingchuan prescription are made to the Dingchuan powder of complying with one's wishes, and then make the preparation capable of permeating skin for point-application, have a significant effect, pass through Clinical observation, in the situation that not using other medicines, total effective rate can reach 94%, and this is very inaccessible in external medicine preparation, so have outstanding substantive distinguishing features and significant progressive.
The same cloves of Dingchuan powder as one wishes, Chinese cassia tree, evodia rutaecarpa, the coptis, Cimetidine combine the transdermal patch acupoint application treatment baby diarrhea of making, before not sticking transdermal patch of the present invention, symptom of diarrhea shows effect repeatedly, stick after transdermal patch of the present invention, basic rehabilitation in 3 days, after stopping sticking, diarrhoea also has no outbreak; Dingchuan powder as one wishes and paracetamol, the wind-weed, indigo naturalis, borneol, mulberry leaf-ginger common cold parenteral solution combine the transdermal patch of making and also have obvious curative effect on treatment children's generate heat repeatedly.
Brief description of the drawings
Fig. 1 is front view of the present invention, and wherein 1 is adhesive layer, and 2 is medicine, and 3 is oval annulus, and 4 is the layer of mounting, and 5 is groove.
Fig. 2 is side view of the present invention, and wherein 6 is chemical heat layer, and 7 is easy tear tape.
Detailed description of the invention
Embodiment 1 preparation Dingchuan powder as one wishes
Prescription:
Gekko 150g, the dried venom of toads (system) 9g, Radix Astragali 500g, earthworm 500g, Chinese ephedra 500g, Radix Codonopsis 500g, semen armeniacae amarae 800g, gingko 500g, dried immature fruit of citron orange 300g, asparagus fern 400g, the fruit of Chinese magnoliavine (wine steaming) 500g, the tuber of dwarf lilyturf 400g, aster 400g, tuber of stemona 200g, fruit of Chinese wolfberry 300g, prepared rhizome of rehmannia 500g, polygala root 200g, lepidium seed 200g, datura flower 200g, gypsum 200g, Radix Glycyrrhizae (honey is processed) 500g
Preparation process:
By the semen armeniacae amarae of recipe quantity, put in boiling water and decoct after 3 hours, filter, obtain semen armeniacae amarae extract; Get earthworm, Radix Codonopsis, gingko, asparagus fern, kadsura longepedunculata, the tuber of dwarf lilyturf, aster, the tuber of stemona, the fruit of Chinese wolfberry, prepared rhizome of rehmannia, polygala root, lepidium seed, partly measure the Radix Astragali, partly measure Radix Glycyrrhizae, after pulverizing, boiling 3 times, three times amount of water is respectively 8 times, 6 times, 6 times, three times decocting time is respectively 3 hours, 2 hours, 1 hour, merge No. three times extract, after filtration, after mixing with semen armeniacae amarae extract, being concentrated into relative density is 1.35(80 DEG C of survey) thick paste;
Get recipe quantity the dried venom of toads, gekko, Chinese ephedra, the dried immature fruit of citron orange, datura flower, gypsum, partly measure the Radix Astragali, partly measure Radix Glycyrrhizae and pulverize respectively, powder particle size is no more than 100 orders, after each Chinese medicine fine powder is mixed, carries out after moist heat sterilization and above-mentioned thick paste mixing granulation, cross 100 mesh sieves, obtain particle, after the particle obtaining is pulverized, cross 10 mesh sieves, sterilizing, dry, be distributed into every bag of 1g, the Dingchuan that must comply with one's wishes powder.
Embodiment 2 preparation Dingchuan powder as one wishes
Prescription:
Gekko 150g, the dried venom of toads (system) 9g, Radix Astragali 500g, earthworm 500g, Chinese ephedra 500g, Radix Codonopsis 500g, semen armeniacae amarae 800g, gingko 500g, dried immature fruit of citron orange 300g, asparagus fern 400g, the fruit of Chinese magnoliavine (wine steaming) 500g, the tuber of dwarf lilyturf 400g, aster 400g, tuber of stemona 200g, fruit of Chinese wolfberry 300g, prepared rhizome of rehmannia 500g, polygala root 200g, lepidium seed 200g, datura flower 200g, gypsum 200g, Radix Glycyrrhizae (honey is processed) 500g
Preparation process:
By the semen armeniacae amarae of recipe quantity, put in boiling water and decoct after 3 hours, filter, obtain semen armeniacae amarae extract; Get earthworm, Radix Codonopsis, gingko, asparagus fern, kadsura longepedunculata, the tuber of dwarf lilyturf, aster, the tuber of stemona, the fruit of Chinese wolfberry, prepared rhizome of rehmannia, polygala root, lepidium seed, partly measure the Radix Astragali, partly measure Radix Glycyrrhizae, after pulverizing, boiling 3 times, three times amount of water is respectively 8 times, 8 times, 6 times, three times decocting time is respectively 2 hours, 1 hour, 1 hour, merge No. three times extract, after filtration, after mixing with semen armeniacae amarae extract, being concentrated into relative density is 1.30(70 DEG C of survey) thick paste;
Get recipe quantity the dried venom of toads, gekko, Chinese ephedra, the dried immature fruit of citron orange, datura flower, gypsum, partly measure the Radix Astragali, partly measure Radix Glycyrrhizae and pulverize respectively, powder particle size is no more than 100 orders, after each Chinese medicine fine powder is mixed, carries out after moist heat sterilization and above-mentioned thick paste mixing granulation, cross 100 mesh sieves, obtain particle, after the particle obtaining is pulverized, cross 100 mesh sieves, sterilizing, dry, be distributed into every bag of 3g, the Dingchuan that must comply with one's wishes powder.
The preparation of embodiment 3 transdermal patches 1
Get 1 bag, Dingchuan powder as one wishes after prepared by embodiment 2 packed, add the azone of 9g, after mixing well, ointment is evenly spread upon to the oval-shaped groove that special size is 5 × 7cm paster central authorities, obtain transdermal patch 1.
The preparation of embodiment 4 transdermal patches 2
Get 1 bag, packed Dingchuan powder as one wishes prepared by embodiment 1,1g Chinese ephedra, the 1g root of Chinese wild ginger, ambroxol 60mg are ground to form to fine-powdered, after mixing with Dingchuan powder as one wishes, add the propane diols of 3 times of amounts of mixing medicinal material total amount, add again clam white injection 1ml, after mixing well, ointment is evenly spread upon to the groove that special size is 4 × 6cm paster central authorities, obtain transdermal patch 2.
The preparation of embodiment 5 transdermal patches 3
Get 1 bag, packed Dingchuan powder as one wishes prepared by embodiment 2,1g rheum officinale, 1g saltcake, ambroxol 60mg are ground to form to fine-powdered, after mixing with Dingchuan powder as one wishes, add azone and a little vaseline of 3 times of amounts of mixing medicinal material total amount, add again clam white injection 1ml, after mixing well, ointment is evenly spread upon to the groove that special size is 5 × 7cm paster central authorities, obtain transdermal patch 3.
The preparation of embodiment 6 transdermal patches 4
Get 1 bag, packed Dingchuan powder as one wishes prepared by embodiment 2, the 1g wind-weed, 1g indigo naturalis, paracetamol 0.6g, borneol 0.3g are ground to form to fine-powdered, after mixing with Dingchuan powder as one wishes, add the azone of 4 times of amounts of the Dingchuan powder of complying with one's wishes, add again mulberry leaf-ginger common cold parenteral solution 1ml, after mixing well, ointment is evenly spread upon to the groove that special size is 4 × 6cm paster central authorities, obtain transdermal patch 4.
The preparation of embodiment 7 transdermal patches 5
Get 1 bag, packed Dingchuan powder as one wishes prepared by embodiment 1,1g cloves, 2g Chinese cassia tree, 1g evodia rutaecarpa, the 1g coptis, Cimetidine 0.8g are ground to form to fine-powdered, after mixing with Dingchuan powder as one wishes, add the comply with one's wishes propane diols of 2 times of amounts of Dingchuan powder weight and the azone of 2 times of amounts of Dingchuan powder weight as one wishes, after mixing well, ointment is evenly spread upon to the groove that special size is 5 × 7cm paster central authorities, obtain transdermal patch 5.
The preparation of embodiment 8 transdermal agents 6
Get 1 bag, Dingchuan powder as one wishes after prepared by embodiment 1 packed, add the azone of 5g and the vaseline of 3g, after mixing well, ointment is evenly spread upon to the oval-shaped groove that special size is 5 × 7cm paster central authorities, obtain transdermal patch 6.
The preparation of embodiment 9 transdermal agents 7
Get 1 bag, Dingchuan powder as one wishes after prepared by embodiment 2 packed, add the propane diols of 6g, after mixing well, ointment is evenly spread upon to the oval-shaped groove that special size is 5 × 7cm paster central authorities, obtain transdermal patch 7.
The curative effect of transdermal patch of the present invention is described by the effect after the patient of corresponding symptom is treated below.
Test example 1 transdermal patch for acupoint application treatment of the present invention is being coughed the clinical testing of breathing heavily
Clinical data
Case selection: select the 80 example children's of 1～5 years old, acute onset, occurs that the symptoms such as cough, expectoration or companion's asthma, heating are as clinical observation object, and the mean body temperature of infant is at 38.8 DEG C. Get rid of pertussis, pulmonary tuberculosis, bronchiectasis etc.
Syndrome Differentiation of Traditional Chinese Medicine: dialectical standard is divided into wind-cold type according to clinical manifestation, anemopyretic with reference to " Chinese Internal Medicine ". Wind-cold type: cough, the thin look of expectoration is white, thin white fur of tongue, floating pulse or floating tight; Anemopyretic: cough, expectoration thickness or thick Huang, thin lingual fur Huang, superficial and rapid pulse.
Grouping
Divide into groups according to Chinese medical discrimination: wherein infant 20 examples of wind-cold type symptom are as treatment group 1, and infant 20 examples of anemopyretic symptom are as treatment group 2; 40 remaining examples, wherein wind-cold type 18 examples as a control group 1, anemopyretic 22 examples as a control group 2.
Efficacy assessment standard
According to " clinical disease diagnosis is according to treatment improvement standard ", be divided into recovery from illness, effective, improvement, invalid, wherein:
Recovery from illness: cough, expectoration, asthma, pulmonary rale and wheezing sound disappear, and body temperature is normal;
Effective: cough, expectoration, asthma alleviate, body temperature retreats to below 37.5 DEG C, and pulmonary rale and wheezing sound reduce;
Take a turn for the better: cough, expectoration, asthma slightly alleviate, and body temperature retreats between 37.6～38.4 DEG C, pulmonary rale and wheezing sound slightly reduce;
Invalid: symptom, sign is unchanged or increase the weight of;
Total effective rate: be recovery from illness, effective, improvement, invalid sum;
Observe bad reaction, and make a record.
Application method
The transdermal patch using is all affixed on patient's fei shu and two acupuncture points of Danzhong, and change another after sticking 12 hours and paste, within 4 days, be a course for the treatment of, a course for the treatment of of acupoint application treatment. Wherein treatment group 1 sticks transdermal patch 2 prepared by embodiment 4, and treatment group 2 sticks transdermal patch 3 prepared by embodiment 5, and control group 1,2 all gives transdermal patch 1 prepared by embodiment 3.
Result
Have an infant sticking after transdermal patch 2 sticking in process, sticking position skin has bubble to occur, after stopping sticking, bubble disappears, and this type of situation does not appear in all the other infants, has no other bad reaction.
Table 1: use the efficacy result contrast of transdermal patch 2,3 and transdermal patch 1
| Recovery from illness | Effective | Take a turn for the better | Invalid | Total effective rate | |
| Control group 1(chill) | 8 | 5 | 4 | 1 | 94.44% |
| Control group 2(wind-heat) | 7 | 7 | 5 | 1 | 95.45% |
| Treatment group 1(chill) | 12 | 6 | 2 | 0 | 100% |
| Treatment group 2(wind-heat) | 13 | 4 | 3 | 0 | 100% |
Shown by the result in table 1,21 taste medicinal materials are made to the transdermal patch for point-application, total effective rate in treatment children's chill wind-heat class disease of cough and asthma can reach 94%, illustrates for the Dingchuan powder as one wishes of point-application and is making good absorbing effect after transdermal patch, and bioavilability is high.
On the basis of transdermal patch 1, add the transdermal patch 2 that Chinese ephedra, the root of Chinese wild ginger, ambroxol, clam white injection are prepared to cough and breathe heavily in acupoint application treatment chill class, have 100% efficient; On the basis of transdermal patch 1, add the transdermal patch 3 that rheum officinale, saltcake, ambroxol, clam white injection are prepared to cough and breathe heavily in acupoint application treatment wind-heat class, have 100% efficient.
Carry out the effect in treatment baby diarrhea and fever in children to the transdermal patch described in the present invention by two cases below:
Case 1Liu so-and-so, man, 4 years old half, because heating is medical repeatedly. This patient was diagnosed as acute upper respiratory infection before 3 days, and body temperature 38.4 is spent, through having an injection, oral drug therapy repeatedly, temperature decline after each treatment, but drug withdrawal body temperature half a day rises again. When medical, body temperature 38.8 is spent, and pharyngeal slightly red, hoarseness, has slight dry cough, flows on a small quantity yellow nasal mucus. Diagnosis: acute upper respiratory infection. Use transdermal patch 4 prepared by embodiment 6 to stick on Dazhui acupoint to this patient, application time 24 hours, sticks 4 days continuously. Coordinate oral drugs to carry out simultaneously, stop intramuscular injection for treating, after certainly sticking, patient repeatedly heating paresthesia disease eliminates.
Case 2Lee so-and-so, man, 1 years old 5 monthly age, because of heating, vomiting, diarrhoea 1 day medical after. Have a medical check-up belly without obvious tenderness, and gurgling sound is hyperfunction, and diarrhoea number of times is frequent, and eye socket slightly caves in; Stool is water sample, not smelly, has foam. Vomitus has tart flavour. Body temperature 37.9 is spent.
Diagnosis: rotavirus enteritis
Therapeutic process: after fall apart+fluid infusion salt+intestinal beneficial bacterium preparation of oral administration of montmorillonite powder, symptom takes a turn for the better, after drug withdrawal, symptom of diarrhea starts again outbreak, transdermal patch 5 prepared by embodiment 7 of the present invention sticks on SHENQUE acupoint and ZHONGWAN acupoint (stick in process need to supplement sodium salt), and the second day patient's mental symptom sticking takes a turn for the better, and dewatering symptom improves, diarrhoea number of times alleviates, and symptoms of emesis disappears substantially. Basic rehabilitation afterwards in 3 days, food, taking light as main, is observed after 3 days, and diarrhoea has no outbreak.
By above test example 1, can draw, the 21 taste medicinal materials of complying with one's wishes in Dingchuan prescription are made to the Dingchuan powder of complying with one's wishes, and then make the preparation capable of permeating skin for point-application, and have a significant effect, pass through Clinical observation, in the situation that not using other medicines, total effective rate can reach 94%, and this is very inaccessible in external medicine preparation, so have outstanding substantive distinguishing features and significant progressive. When use comply with one's wishes Dingchuan powder and Chinese ephedra, the root of Chinese wild ginger, ambroxol, clam white injection combine the transdermal patch acupoint application treatment wind-cold type of making cough breathe heavily have 100% efficient; Comply with one's wishes Dingchuan powder and rheum officinale, saltcake, ambroxol, clam white injection combine the transdermal patch acupoint application treatment anemopyretic of making cough breathe heavily have 100% efficient, the result for the treatment of that therefrom can draw the transdermal patch that the present invention makes by the combination of Chinese medicine and Western medicine is obvious, has outstanding substantive distinguishing features and significant progressive.
Two cases have provided respectively the treatment results of acupoint application treatment fever in children and baby diarrhea, result shows, the same cloves of Dingchuan powder as one wishes, Chinese cassia tree, evodia rutaecarpa, the coptis, Cimetidine combine the transdermal patch acupoint application treatment baby diarrhea of making, before not sticking transdermal patch of the present invention, symptom of diarrhea shows effect repeatedly, sticks after transdermal patch of the present invention basic rehabilitation in 3 days, after stopping sticking, diarrhoea also has no outbreak; Dingchuan powder as one wishes and paracetamol, the wind-weed, indigo naturalis, borneol, mulberry leaf-ginger common cold parenteral solution combine the transdermal patch of making and also have obvious curative effect on treatment children's generate heat repeatedly.
Clam white injection of the present invention, mulberry leaf-ginger common cold parenteral solution, paracetamol, ambroxol, Cimetidine all have sale on market.
Claims (9)
1. for a transdermal patch for acupoint application treatment, it is characterized in that, the constituent of described transdermal patch and weight ratio thereof are the Dingchuan powder of complying with one's wishes: auxiliary material=1:2～4, further, Dingchuan powder: auxiliary material=1:3 complies with one's wishes.
2. the transdermal patch for acupoint application treatment, it is characterized in that, the constituent of described transdermal patch is Dingchuan powder 1～3g, Chinese ephedra 1g, root of Chinese wild ginger 1g, the ambroxol 60mg of complying with one's wishes, wherein the weight ratio of auxiliary material and medicine is 3:1, recombinant clam white injection 1ml, is used for the treatment of the disease of cough and asthma of chill class.
3. the transdermal patch for acupoint application treatment, it is characterized in that, the constituent of described transdermal patch is Dingchuan powder 1～3g, rheum officinale 1g, saltcake 1g, the ambroxol 60mg of complying with one's wishes, wherein the weight ratio of auxiliary material and medicine is 3:1, recombinant clam white injection 1ml, is used for the treatment of the disease of cough and asthma of wind-heat class.
4. according to the transdermal patch described in claim 1-3, it is characterized in that, described auxiliary material is one or more in azone, propane diols, oleic acid, menthol, salicylic acid, vaseline, further, and preferably one or more in azone, propane diols, vaseline.
5. for a preparation method for the transdermal patch of acupoint application treatment, it is characterized in that, the preparation method of described transdermal patch is:
(1) by the semen armeniacae amarae of recipe quantity, put in boiling water and decoct, filter, obtain semen armeniacae amarae extract;
(2) get earthworm, Radix Codonopsis, gingko, asparagus fern, kadsura longepedunculata, the tuber of dwarf lilyturf, aster, the tuber of stemona, the fruit of Chinese wolfberry, prepared rhizome of rehmannia, polygala root, lepidium seed, partly measure the Radix Astragali, partly measure Radix Glycyrrhizae, after pulverizing, boiling 2～3 times, each decocting time is 1～3 hour, each amount of water is 6～8 times of above-mentioned dry medicinal material total amount, filter, merge extract;
(3) the semen armeniacae amarae extract in step (1) is mixed with the extract in step (2), being concentrated into relative density is the thick paste of more than 1.30 (70～80 DEG C of surveys);
(4) get the dried venom of toads, gekko, Chinese ephedra, the dried immature fruit of citron orange, datura flower, gypsum, partly measure the Radix Astragali, partly measure Radix Glycyrrhizae and pulverize respectively, after each Chinese medicine fine powder is mixed, carry out moist heat sterilization, mix with the thick paste obtaining in step (3), carry out wet granulation, cross 100 mesh sieves, obtain particle;
(5), after the particle obtaining in step (4) is pulverized, cross 10～100 mesh sieves, sterilizing, dry, be distributed into every bag of 1～3g, the Dingchuan that must comply with one's wishes powder;
(6) prepare the preparation method of 1 note: get 1 bag, the packed Dingchuan powder as one wishes that obtains in step (5), be equipped with pharmaceutically feasible auxiliary material, after mixing well, tear the easy tear tape of paster top, ointment is evenly spread upon to the oval-shaped groove place of paster central authorities, then transdermal patch is affixed on to corresponding acupuncture point place, the heat producing after contacting with air by chemical heat layer is accelerated the Transdermal absorption of medicine; Patch size is that 5 × 7cm or 4 × 6cm are more suitable.
6. transdermal patch according to claim 5, is characterized in that, the acupuncture point described in step (6) is at least one or more in fei shu cave and SHANZHONG acupoint.
7. transdermal patch according to claim 1, it is characterized in that, in described transdermal patch, can also combine the wind-weed, indigo naturalis, borneol, mulberry leaf-ginger common cold parenteral solution is made transdermal patch, be affixed on big vertebra and/or SHENQUE acupoint treatment heating, wherein, ingredients composition is: comply with one's wishes Dingchuan powder 1～3g, paracetamol 0.6g, wind-weed 1g, indigo naturalis 0.5g, borneol 0.3g, mulberry leaf-ginger common cold parenteral solution 1ml.
8. transdermal patch according to claim 1, it is characterized in that, in described transdermal patch, can combine cloves, Chinese cassia tree, evodia rutaecarpa, the coptis, Cimetidine and make transdermal patch, be affixed on SHENQUE acupoint and can treat the baby diarrhea of outbreak repeatedly, add and be attached to ZHONGWAN acupoint if any symptoms of emesis, wherein, ingredients composition is: Dingchuan powder 1～3g, cloves 1g, Chinese cassia tree 2g, evodia rutaecarpa 1g, coptis 1g, Cimetidine 0.8g comply with one's wishes.
9. transdermal patch according to claim 1, is characterized in that, the back side of described transdermal patch with one with circle or oval-shaped groove from zone of heating.
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| CN106390066A (en) * | 2016-10-26 | 2017-02-15 | 重庆医药高等专科学校 | Traditional Chinese medicine composition for acupoint application to treat infantile common cold |
| CN106420674A (en) * | 2016-11-11 | 2017-02-22 | 邓蜀俐 | Pharmaceutical composition of transdermal patch for treating respiratory diseases and transdermal patch |
| CN109481471A (en) * | 2019-01-25 | 2019-03-19 | 上海真仁堂药业有限公司 | The preparation method of dried venom of toads powder medicine materical crude slice |
| CN115721698A (en) * | 2022-10-09 | 2023-03-03 | 湖北理工学院 | Acupoint application for warming yang and eliminating dampness by adopting traditional Chinese medicines and preparation process thereof |
| USD1077245S1 (en) | 2022-07-16 | 2025-05-27 | Aso Llc | Transdermal foot patch |
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| CN106420674A (en) * | 2016-11-11 | 2017-02-22 | 邓蜀俐 | Pharmaceutical composition of transdermal patch for treating respiratory diseases and transdermal patch |
| CN109481471A (en) * | 2019-01-25 | 2019-03-19 | 上海真仁堂药业有限公司 | The preparation method of dried venom of toads powder medicine materical crude slice |
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