CN102614436B - Chinese medicinal preparation for treating pulmonary heart disease and preparation method for Chinese medicinal preparation - Google Patents
Chinese medicinal preparation for treating pulmonary heart disease and preparation method for Chinese medicinal preparation Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal preparation for treating pulmonary heart disease. The Chinese medicinal preparation is prepared from the following Chinese herbal medicines in part by weight: 20 to 45 parts of coix seed, 20 to 45 parts of reed rhizome, 6 to 12 parts of peach kernel, 20 to 45 parts of white gourd kernel, 20 to 45 parts of bryozoatum, 20 to 26 parts of snake gourd seed, 20 to 30 parts of pepper weed seed, 6 to 12 parts of stemona, 6 to 15 parts of almond, 2 to 6 parts of ginseng, 12 to 25 parts of dwarf lilyturf root, 3 to 9 parts of schisandra, 6 to 12 parts of fritillaria, 10 to 20 parts of anemarrhena rhizome, and 0.02 to 0.3 part of borneol. The selected materials are traditional Chinese medicinal materials, so the preparation does not have any toxic or side effect; the formula is completely in accordance with Chinese medicinal principles and physical and mental characteristics of heart disease patients; and on the premise of total principles, the preparation can have different formulas according to different crowds and have different functions. The medicament sources are readily available, the costs of the medicinal materials are low, and the burden of the patients can be lightened.
Description
Technical field
The present invention relates to the Chinese medicine field, particularly relate to a kind of Chinese medicine preparation for the treatment of pulmonary heart disease and preparation method thereof.
Background technology
The most common person of chronic pulmonary heart disease is the courageous and upright pulmonary heart disease of chronic hypoxia, claim again obstructive emphysema heart disease, be called for short pulmonary heart disease, refer to be increased by the pulmonary vascular resistance that pulmonary's thorax or Pulmonic chronic disease cause, cause pulmonary hypertension and right ventricular hypertrophy, companion or without a class heart disease of right heart failure.Pulmonary heart disease is commonly encountered diseases in China, frequently-occurring disease.
The Early manifestation of chronic cardiopulmonary disease is long-term cough, expectoration and dyspnea in various degree, particularly movable after or in cold season symptom more obvious.Pulmonary heart disease early stage, cardio-pulmonary function are in generation and taste the phase, and the patient does not have specific symptom, and patient can not have symptom when quiet, so this disease is difficult for coming into the picture.But as long as following situation occurs, often prompting has suffered from pulmonary heart disease: 1, prolonged and repeated cough, expectoration.2, every cold season aggravation, the cough aggravation, amount of expectoration increases, thickens or is yellow.3, movable a little as when going upstairs or walking at a quick pace, feel to breathe hard, rapid breathing, cardiopalmus, precordialgia, the symptom such as weak, uncomfortable in chest, can take a turn for the better after rest.4, finger tip, lip and lip surrounding are livid purple color.5, heart rate is accelerated, arrhythmia.Pulmonary heart disease can cause heart change: right ventricular hypertrophy, locular wall thicken, dilatation of heart, pulmonary conus bulge, cardiac muscle fiber have the changes such as hypertrophy and atrophy, interstitial edema, and the kitchen range type is downright bad, is substituted by fibrous tissue after necrosis region.Some patients were can merge coronary artery lesion.
The treatment of pulmonary heart disease with antitussive, eliminate the phlegm, relieving asthma and the symptomatic treatment such as infection.Or use to improve as subcutaneous in nucleic acid casein injection (or expired measles attenuated vaccine) or the intramuscular injection of immunity of organisms medicine and (or) atomizing sucks, each 2～4ml, the casein of secondary, or nucleic acid weekly oral liquid 10ml/ props up, 3 times/d, be a course for the treatment of 3～June.Vaccinum Bronehitidis subcutaneous injection, immune ribonucleic acid, placental lipo-glucosaminoglycan intramuscular injection, Radix Ginseng, transfer factor, levamisole are oral etc.
Compare with western medicine and medical practitioners, by Chinese traditional treatment, toxic and side effects is lighter, is more vulnerable to numerous medical personnels and friend's patient favor.The Chinese patent literature of Granted publication CN 1294926C (application number 200410015856.2) provides a kind of formula of Chinese medicine composition for the treatment of pulmonary heart disease and has prepared native skill, comprise stock and adjunct, the composition of raw materials proportioning is Radix Astragali 1-5 part, Semen Lepidii (Semen Descurainiae) 1-5 part, Rhizoma Chuanxiong 1-5 part, draw together building skin 1-5 part and adjuvant forms.The Chinese patent literature of Granted publication CN 100496530C (application number 200410018562.5) relates to a kind of Chinese medicine composition for the treatment of pulmonary heart disease, comprise medium-height grass medicinal herbs Semen Lepidii (Semen Descurainiae), Rhizoma Chuanxiong, formula is comprised of Semen Lepidii (Semen Descurainiae) or its extract 1-3 part, Rhizoma Chuanxiong or its extract 1-2 part and suitable adjuvant by portion rate preparation.Publication number CN 101229267A (application number 200810056134.X) relates to a kind of pharmaceutical composition for the treatment of pulmonary heart disease and rheumatic heart disease and preparation method thereof, and it is mainly made by Semen Persicae, Flos Carthami, Radix Angelicae Sinensis, the Radix Rehmanniae, CHUANSHAO, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Radix Platycodonis, Radix Bupleuri, long-pending reality and Radix Glycyrrhizae.
Although the medicine that provides in prior art more or less all has some curative effects on the treatment pulmonary heart disease, the part prescription brings certain toxic and side effects more or less can for patient's gastrointestinal, Liver and kidney.Generally speaking, present treatment for pulmonary heart disease there is no desirable definite treatment by Chinese herbs medicine.
Summary of the invention
For the deficiencies in the prior art, the purpose of this invention is to provide and a kind ofly prepare simple, taking convenience, be easy to carry, easy Chinese medicine preparation of the treatment pulmonary heart disease of clothes and preparation method thereof for a long time.This Chinese medicine composition determined curative effect and having no side effect.
Technical scheme of the present invention is:
The Chinese medicine preparation for the treatment of pulmonary heart disease is prepared from by following bulk drugs, is weight portion: Semen Coicis 20-45, Rhizoma Phragmitis 20-45, Semen Persicae 6-12, Semen Benincasae 20-45, Pumex 20-45, Semen Trichosanthis 20-26, Semen Lepidii (Semen Descurainiae) 20-30, Radix Stemonae 6-12, Semen Armeniacae Amarum 6-15, Radix Ginseng 2-6, Radix Ophiopogonis 12-25, Fructus Schisandrae Chinensis 3-9, Bulbus Fritillariae Uninbracteatae 6-12, Rhizoma Anemarrhenae 10-20, Borneolum Syntheticum 0.02-0.3.In preferred scheme, Semen Coicis 25-35, Rhizoma Phragmitis 25-35, Semen Persicae 9-10, Semen Benincasae 25-35, Pumex 25-35, Semen Trichosanthis 22-24, Semen Lepidii (Semen Descurainiae) 22-28, Radix Stemonae 9-10, Semen Armeniacae Amarum 9-12, Radix Ginseng 3-5, Radix Ophiopogonis 15-20, Fructus Schisandrae Chinensis 5-8, Bulbus Fritillariae Uninbracteatae 9-10, Rhizoma Anemarrhenae 12-15, Borneolum Syntheticum 0.08-0.2 (preferred 0.1-0.15).What be more preferably is, Semen Coicis 30, Rhizoma Phragmitis 30, Semen Persicae 9.5, Semen Benincasae 30, Pumex 30, Semen Trichosanthis 23, Semen Lepidii (Semen Descurainiae) 26, the Radix Stemonae 9.5, Semen Armeniacae Amarum 10, Radix Ginseng 4, Radix Ophiopogonis 18, Fructus Schisandrae Chinensis 6, Bulbus Fritillariae Uninbracteatae 9.5, the Rhizoma Anemarrhenae 13, Borneolum Syntheticum 0.12.
Foregoing Chinese medicine preparation preferably, is made pharmaceutically acceptable water preparation, powder, tablet or capsule with this Chinese medicine preparation.
The preparation method of described water preparation is:
(1) Semen Coicis, Rhizoma Phragmitis, Semen Persicae, Semen Benincasae, Pumex, Semen Trichosanthis, Semen Lepidii (Semen Descurainiae), the Radix Stemonae, Semen Armeniacae Amarum, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Bulbus Fritillariae Uninbracteatae and the Rhizoma Anemarrhenae are pulverized, crossed 120-140 mesh sieve (preferred 130 mesh sieves), get fine powder;
(2) with step (1) gained fine powder mix homogeneously, be placed in penetrating bag, the cold water that is 20-40 ℃ (preferred 30 ℃) with temperature soaks 6-8 hour (preferred 7 hours), and water consumption is 3-4 times (preferred 3.5 times) of described fine powder weight;
(3) be heated to boiling, take out penetrating bag after lasting 0.6-1.2 hour (preferred 0.8-1.0 hour), gained liquid gets concentrated solution through being concentrated into the 1/2-1/3 of original volume;
(4) will add in the concentrated solution of step (3) gained after the Borneolum Syntheticum grinding, sterile packaged namely gets the Chinese medicine composition water preparation.
The preparation method of described powder is: each crude drug was pulverized 60-100 mesh sieve (preferred 80-85 mesh sieve), get the Chinese medicine composition medicinal powder.
The preparation method of described tablet is: claim 6 gained Chinese medicine composition medicinal powder according to 0.2-0.3g/ sheet (preferred 0.25g/ sheet) metering, is pressed into circular or other forms of lamellar dosage form according to the preparation for processing of tablet.
The preparation method of described tablet is: claim 6 gained Chinese medicine composition medicinal powder according to 0.2-0.3g/ grain (preferred 0.25g/ grain) metering, is processed into the capsule shape dosage form according to the preparation for processing of capsule.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Semen Coicis: nature and flavor: sweet, light.Cool.Gui Jing: return spleen, stomach, lung meridian.Effect: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, clearing away heat and discharging pus.Cure mainly: be used for edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, pain in the lung, intestinal carbuncle; Verruca plana." book on Chinese herbal medicine is stated ": Semen Coicis, dehumidifying and not as two arts help dry, heat clearing away and not as a kind of reed mentioned in ancient books, connect the generation and damage the moon, QI invigorating and still grow damp and hotly not as ginseng, art generation is really gas key medicine in benefit.So it is lightly seasoned, and its power is slow, and with Ji, thick collection is to throw as unsocial, its right effect of playing of Ji also? " book on Chinese herbal medicine newly organized ": the kind diuretic of Semen Coicis, the gas that unlikely loss is Kidney-Yin, all wet persons that is contained in the lower part of the body the most suitablely use it, depending on the weight of disease, few more than mutatis mutandis medicine, negative and positive are not hindered, and damp disease is easily gone.Therefore the disease that all chance water is wet is monarch with Semen Coicis one, two liang, and the flavor that the spleen invigorating of assistant is dried, do not have not fast in the person of proving effective also, if thin its abnormal smells from the patient gentle and gently use it is also unhelpful.
Rhizoma Phragmitis: nature and flavor: sweet, cold.Gui Jing: attach to the lung and stomach meridians.Effect: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: be used for the calentura excessive thirst, the gastric heat sound of vomiting of vomitting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.
Semen Persicae: nature and flavor: bitter, sweet, flat.Gui Jing: GUIXIN, liver, large intestine channel.Effect: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.Cure mainly: be used for amenorrhea. dysmenorrhea. mass in the abdomen mass in the abdomen, injury from falling down, dryness of the intestine constipation.Modern study, it contains amygdalin (Amygdalin), emulsin (Emulsin), allantoinase (Allantoinase), Lactose enzyme (Lactase), vitamin B1. volatile oil, fatty oil, mainly containing olein and a small amount of glyceryl linoleate in oil. emulsin comprises amygdalase (Amygdalase) and prunase (Prunase). the amygdalin in Semen Persicae is the same with amygdalin in Semen Armeniacae Amarum, produces hydrocyanic acid, benzaldehyde and glucose after enzyme or acid hydrolysis.
Semen Benincasae: be the seed of cucurbitaceous plant Fructus Benincasae.Property is sweet, cool.Cold, nontoxic.Enter meridian of Foot-JUE YIN.But removing heat from the lung and dissipating phlegm; The eliminating carbuncle evacuation of pus; Dampness removing.Main phlegm-heat cough; Lung abscess; The intestinal carbuncle; Nebulousurine; Leukorrhagia; Foot gas; Edema; Stranguria.
Pumex: another name spray (supplement to the Herbal), white Pumex, Pumex, Hai Shi (" danxi's experiential therapy "), blister stone (" Dong-eui-bo-gam "), large Pumex, Pumex (" beautiful Chinese catalpa medicine solution "), PUMEX (" the medical center bun is wanted "), Gaster caprae seu Ovis stone (" medical material compilation of data ").Gui Jing: lung; Kidney; Liver; Large intestine channel.Nature and flavor: salty, cold.The lung heat clearing fire is changed old expectorant, and softening the hard mass is treating stranguria.Control the expectorant dyspnea of heat type and cough, old accumulation of phlegm piece, goiter, scrofula, gonorrhea, hernia, skin ulcer is swollen, corneal nebula.Removing heat from the lung and dissipating phlegm, hard masses softening and resolving.Be used for the cough due to lung-heat, yellowish thick sputum, spitting of blood, bronchitis, tuberculous lymphadenitis.Medical material divides Pumex and coral two classes.Pumex is the formed stone of magma that volcanic eruption goes out; Coral is the dry skeleton of the born of the same parents animal costazia aculeata Canu et Bassler Costazia aculeata Canu et Bassler of section or costazia costazii Audouin Costazia costazii Audouin.Pumex can be adopted the whole year, pulls out from marine, chooses only and dries.Autumn in coral summer is pulled out from marine, and clear water washes away salt matter and silt, dries.
Fructus Trichosanthis (core): feeble QI, sweet in the mouth, little bitterness.Compendium of Material Medica volume 18 years: Fructus Trichosanthis " lung moistening is dry, pathogenic fire reducing, control that cough, clearing away phlegm ties, only quenched one's thirst, sharply defecate, the subduing inflammation sore ".Modern medicine and pharmacology studies confirm that: Fructus Trichosanthis contains unsaturated fatty acid 16.8%, protein 5.46%, and contain 17 seed amino acids, three paste Saponin, 16 kinds of trace element such as multivitamin and calcium, ferrum, zinc, selenium.Edible Fructus Trichosanthis (core) has expansion heart arteria coronaria, increases the coronary flow effect; Acute myocardial ischemia there is significant protective effect; Exsomatize choriocarcinoma cell propagation and HIV (human immunodeficiency virus) had strong inhibitory action.
Semen Lepidii (Semen Descurainiae): nature and flavor: hot, bitter, Great Cold.Gui Jing: return lung, urinary bladder channel.Effect: dirty lung is relievingd asthma, line water detumescence.Cure mainly: be used for sputum and stop up lung, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium must not be put down sleepingly, and ascites pleural fluid is swollen, dysuria; The pulmonary heart disease edema.
The Radix Stemonae: nature and flavor: sweet, bitter, tepor.Gui Jing: return lung meridian.Effect: nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Cure mainly: be used for new chronic cough and cough, pulmonary tuberculosis cough, pertussis; Outer head louse, body louse, enterobiasis, the pudendal pruritus of being used for.Honey Radix Stemonae nourishing the lung to arrest cough.Be used for deficiency of YIN chronic cough.
Semen Armeniacae Amarum nature and flavor: hardship, tepor; Slightly poisonous.Gui Jing: return lung, large intestine channel.Effect: sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.Curing mainly: be used for cough and asthma. the fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, the dryness of the intestine constipation.
Borneolum Syntheticum (preferred natural Broneolum Syntheticum): property is arduous, and is cool.Can " treat sore throat, headache, breath, toothache, the typhoid fever protrusion of the tongue, children's's pox falls into.Logical all keys, loose stagnated fire." (" detailed outline ").
Radix Ginseng: nature and flavor: sweet, little hardship, flat.Gui Jing: return spleen, lung, heart channel.Effect: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, and calms the nerves.Cure mainly: be used for weak body and prostration, the cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, and prolonged illness is empty wins, the palpitation with fear insomnia, sun layer official is cold; Heart failure, cardiogenic shock.
Radix Ophiopogonis: nature and flavor: sweet, little hardship is slightly cold.Gui Jing: GUIXIN, lung, stomach warp.Effect: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Cure mainly: be used for dryness of the lung dry cough.The chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, the dryness of the intestine constipation; Pharyngeal diphtheria.
Fructus Schisandrae Chinensis: nature and flavor: sour, sweet, temperature.Gui Jing: return lung, the heart, kidney channel.Effect: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Cure mainly: be used for the chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Bulbus Fritillariae Uninbracteatae (Bulbus Fritillariae Thunbergii): nature and flavor: hardship, cold.Gui Jing: return lung, heart channel.Effect: heat clearing away eliminating stagnation. preventing phlegm from forming and stopping coughing cures mainly: be used for wind-heat invading the lung, phlegm-fire cough, lung abscess, mastalgia, scrofula, sore.
The Rhizoma Anemarrhenae: nature and flavor: bitter, sweet, cold.Gui Jing: return lung, stomach, kidney channel.Effect: clearing away heat-fire, promote the production of body fluid and moisturize.Cure mainly: be used for fever caused by exogenous pathogenic factors. high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, the dryness of the intestine constipation.
Chinese medicine composition prescription science provided by the invention, the preparation method of various dosage forms is simple, the products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, selected materials is all the Chinese medicine material, and is without any side effects;
2, this prescription meets Chinese medicine principle and pulmonary heart disease, cardiac's body and mind characteristics fully, under the prerequisite of general principle, can different prescriptions be arranged according to different crowd, and function is different.
3, the medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
The specific embodiment
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
The Chinese medicine preparation of embodiment 1 treatment pulmonary heart disease is prepared from by following bulk drugs, is weight portion (every part of 1kg): Semen Coicis 20, Rhizoma Phragmitis 20, Semen Persicae 6, Semen Benincasae 20, Pumex 20, Semen Trichosanthis 20, Semen Lepidii (Semen Descurainiae) 20, the Radix Stemonae 6, Semen Armeniacae Amarum 6, Radix Ginseng 2, Radix Ophiopogonis 12, Fructus Schisandrae Chinensis 3, Bulbus Fritillariae Uninbracteatae 6, the Rhizoma Anemarrhenae 10, Borneolum Syntheticum 0.02.The preparation method of the Chinese medicine preparation water preparation of above-mentioned treatment pulmonary heart disease:
(1) Semen Coicis, Rhizoma Phragmitis, Semen Persicae, Semen Benincasae, Pumex, Semen Trichosanthis, Semen Lepidii (Semen Descurainiae), the Radix Stemonae, Semen Armeniacae Amarum, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Bulbus Fritillariae Uninbracteatae and the Rhizoma Anemarrhenae are pulverized, crossed 140 mesh sieves, get fine powder;
(2) with step (1) gained fine powder mix homogeneously, be placed in penetrating bag, be the cold water immersion 8 hours of 40 ℃ with temperature, water consumption is 4 times of described fine powder weight;
(3) be heated to boiling, continue to take out penetrating bag after 1.2 hours, gained liquid gets concentrated solution through being concentrated into the 1/2-1/3 of original volume;
(4) will add in the concentrated solution of step (3) gained after the Borneolum Syntheticum grinding, sterile packaged namely gets the Chinese medicine composition water preparation.
The instructions of taking of water preparation of the present invention: water preparation is 7 days courses for the treatment of, takes every day twice (warm), each 350ml-500ml.
The Chinese medicine preparation of embodiment 2 treatment pulmonary heart diseases is prepared from by following bulk drugs, is weight portion (every part of 70g): Semen Coicis 45, Rhizoma Phragmitis 45, Semen Persicae 12, Semen Benincasae 45, Pumex 45, Semen Trichosanthis 26, Semen Lepidii (Semen Descurainiae) 30, the Radix Stemonae 12, Semen Armeniacae Amarum 15, Radix Ginseng 6, Radix Ophiopogonis 25, Fructus Schisandrae Chinensis 9, Bulbus Fritillariae Uninbracteatae 12, the Rhizoma Anemarrhenae 20, Borneolum Syntheticum 0.3.
The preparation method of the Chinese medicine preparation powder of above-mentioned treatment pulmonary heart disease is: each crude drug was pulverized 100 mesh sieves, get the Chinese medicine composition medicinal powder, and divided the 0.4g/ bag with powder; Adopt every day 2-3 time, each one bag, use warm boiled water, 7 days courses for the treatment of.
Model case: xxx, the man, 87 years old, retired doctor the paroxysmal cough occurred without obvious inducement from 1964, expectoration, white mucus expectorant, the sputum mixed with blood silk, be diagnosed as " bronchitis " at that time sometimes, alleviates after the penicillin treatment.After this weather cools off and winter-spring season shows effect repeatedly, takes a turn for the better after taking antibiotic and cough suppressing medicine.After nineteen ninety-five, cough, expectoration increase the weight of, and play aggravation morning, cough white foam expectorant, after movable as stair climbing, skelp etc. and to feel cardiopalmus, tachypnea, can alleviate after rest, in JIUYUE, the 2003 rear cough of drenching with rain increases the weight of, coughs yellow purulent sputum, amount is few, and obvious tachypnea, cardiopalmus and edema of pair of lower extremities are accompanied in difficult expectoration.Successively give cefoperazone, lomefloxacin, aminophylline and treatment by Chinese herbs in the locality, improve not obviously, walk level road and also feel and breathing hard.The rear sense cardiopalmus, tachypnea of suffering from cold before 10 days increases the weight of again, and can not put down sleeping night, and the urine amount reduces, low grade fever is arranged, the body temperature fluctuation is at 37.5 ℃--and 38.0 ℃, white mucus expectorant is coughed in cough, measure how about every day of 100ml, without night sweat, chest pain and spitting of blood, the oxygen uptake and taking of being in is brought down a fever, symptom is without alleviation after cough-relieving, Apophlegmatisant, and outpatient service is received people institute with " chronic bronchitis; emphysema, pulmonary heart disease and respiratory failure ".Previously body is strong, and 55 years smoking histories are arranged, and every day, 20--30 propped up, and gave up smoking in nineteen ninety-five.Without drinking hobby.
Take the Chinese medicine preparation powder of the present embodiment gained treatment pulmonary heart disease, each one bag, every day 3 times, warm boiled water, 7 days courses for the treatment of.Took 21 days, chest pain, cough alleviate, and confusingly in the heart also alleviate, and the amount of receiving increases, spirit can, took 5 months, symptom is eliminated, the peace of sleeping night, vexed removing, strength increases, receive food can, continuing takes 12 months, does not occur any discomfort when the patient takes, the self-induction recovery from illness.
The Chinese medicine preparation of embodiment 3 treatment pulmonary heart diseases is prepared from by following bulk drugs, is weight portion (every part of 50g): Semen Coicis 35, Rhizoma Phragmitis 35, Semen Persicae 10, Semen Benincasae 35, Pumex 35, Semen Trichosanthis 24, Semen Lepidii (Semen Descurainiae) 28, the Radix Stemonae 10, Semen Armeniacae Amarum 12, Radix Ginseng 5, Radix Ophiopogonis 20, Fructus Schisandrae Chinensis 8, Bulbus Fritillariae Uninbracteatae 10, the Rhizoma Anemarrhenae 15, Borneolum Syntheticum 0.2.
The preparation method of the Chinese medicine preparation tablet for the treatment of pulmonary heart disease is: each crude drug was pulverized 60 mesh sieves, get the Chinese medicine composition medicinal powder.Gained Chinese medicine composition medicinal powder according to 0.25g/ sheet metering, is pressed into circular or other forms of lamellar dosage form according to the preparation for processing of tablet.Tablet adopts every day 3 times, and each 2-4 sheet is used warm boiled water, 7 days courses for the treatment of.
Model case: xxx, women, 54 years old, people from Hanzhong.The patient had the asthma medical history more than 30 year, often cough at ordinary times, and feel asthma, out of breath and feel suffocated.In January, 2006 unexpected sx↑, sweating due to debility is dripping, lower limbs edema, the green around the gills emergency treatment is rescued at local hospital, cardiac function level Four at that time, the Color Sonography prompting enlarges whole-heartedly, heart failure, lung A high pressure.Because the state of an illness is critical, local doctor informs that patient treatment wishes not quite.
For seeking better treatment, the patient begins to take the Chinese medicine preparation tablet of the present embodiment gained treatment pulmonary heart disease in March, 2008, adopt every day twice, each 4, uses warm boiled water, 7 days courses for the treatment of.Took 21 days, precordialgia, cough alleviate, and fatigue and weak also alleviates, and the amount of receiving increases, spirit can, took 5 months, the blood supply of electrocardio diagram coronary artery obviously improves, continuing takes 12 months, the recovery from illness of patient's self-induction.
The Chinese medicine preparation of embodiment 4 treatment pulmonary heart diseases is prepared from by following bulk drugs, is weight portion (every part of 25g): Semen Coicis 25, Rhizoma Phragmitis 25, Semen Persicae 9, Semen Benincasae 25, Pumex 25, Semen Trichosanthis 22, Semen Lepidii (Semen Descurainiae) 22, the Radix Stemonae 9, Semen Armeniacae Amarum 9, Radix Ginseng 3, Radix Ophiopogonis 15, Fructus Schisandrae Chinensis 5, Bulbus Fritillariae Uninbracteatae 9, the Rhizoma Anemarrhenae 12, Borneolum Syntheticum 0.08.
The preparation method of the Traditional Chinese medicine preparation capsule agent for the treatment of pulmonary heart disease is: each crude drug was pulverized 80 mesh sieves, get the Chinese medicine composition medicinal powder.Gained Chinese medicine composition medicinal powder according to 0.25g/ grain metering, is processed into the capsule shape dosage form according to the preparation for processing of capsule.
The Chinese medicine preparation of embodiment 5 treatment pulmonary heart diseases is prepared from by following bulk drugs, is weight portion (every part of 10g): Semen Coicis 30, Rhizoma Phragmitis 30, Semen Persicae 9.5, Semen Benincasae 30, Pumex 30, Semen Trichosanthis 23, Semen Lepidii (Semen Descurainiae) 26, the Radix Stemonae 9.5, Semen Armeniacae Amarum 10, Radix Ginseng 4, Radix Ophiopogonis 18, Fructus Schisandrae Chinensis 6, Bulbus Fritillariae Uninbracteatae 9.5, the Rhizoma Anemarrhenae 13, Borneolum Syntheticum 0.12.
The preparation method of the Chinese medicine preparation water preparation for the treatment of pulmonary heart disease is:
(1) Semen Coicis, Rhizoma Phragmitis, Semen Persicae, Semen Benincasae, Pumex, Semen Trichosanthis, Semen Lepidii (Semen Descurainiae), the Radix Stemonae, Semen Armeniacae Amarum, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Bulbus Fritillariae Uninbracteatae and the Rhizoma Anemarrhenae are pulverized, crossed 130 mesh sieves, get fine powder;
(2) with step (1) gained fine powder mix homogeneously, be placed in penetrating bag, be the cold water immersion 7 hours of 30 ℃ with temperature, water consumption is 3.5 times of described fine powder weight;
(3) be heated to boiling, continue to take out penetrating bag after 1.0 hours, gained liquid gets concentrated solution through being concentrated into the 1/2-1/3 of original volume;
(4) will add in the concentrated solution of step (3) gained after the Borneolum Syntheticum grinding, sterile packaged namely gets the Chinese medicine composition water preparation.
The clinical practice of the Chinese medicine preparation water preparation of test example 1 embodiment 5 gained treatments pulmonary heart diseases: in JIUYUE, 2009-2011 year December, 3 second-rank first class hospitals screening 120 routine patients with cor pulmonale, wherein women's 62 examples, male's 58 examples, oldest 75 years old, minimal ages 35 years old, 57.8 years old mean age.2 weeks before test, this crowd is carried out Continuous Observation, record symptom and variation, be divided at random two groups, experimental group and matched group, experimental group are taken embodiment 5 products obtained therefroms, and matched group is taken other medicine (the conventional medicines such as hydrochlorothiazide, metoprolol).Using method is: take twice (warm) each 350ml-500ml (adjusting to some extent depending on concrete condition), 10 days courses for the treatment of every day.Curative effect situation criterion: cure: take 3 courses for the treatment of of this product, cough obviously improves, and the blood supply of electrocardio diagram coronary artery obviously improves, and malaise symptoms disappears, and energy and muscle power obviously strengthen; Effectively: take 3 courses for the treatment of of this product, the cough sx↓, the chronic coronary artery blood supply of electrocardio diagram improves, and malaise symptoms alleviates or part disappears, and energy and muscle power strengthen; Invalid: take 3 courses for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 5 product 35-75 year pulmonary heart disease crowd therapeutic outcomes
Therapeutic effect: cure 74 examples (74%), effective 25 examples (25%), invalid 1 example (1%), total effective rate 99%.Successful is better than matched group.
During taking, self-induction symptom and physical change of spirit thereof are as shown in table 2.
Table 2:
Pulmonary heart disease delay is difficult, and the present invention is with a thousand pieces of gold weijing decoction (Chinese medicine decoction that is comprised of Rhizoma Phragmitis, Semen Coicis, melon lobe, Semen Persicae etc.Present multiplex Rhizoma Phragmitis replaces Rhizoma Phragmitis, and Semen Benincasae replaces the melon lobe.This medicine is usually used in the treatment of the diseases such as pulmonary abscess, lobar pneumonia, bronchitis, pertussis clinically) be source, with the Rhizoma Anemarrhenae, Bulbus Fritillariae Uninbracteatae, Pumex, Semen Trichosanthis removing heat from the lung and dissipating phlegm; Semen Lepidii (Semen Descurainiae), Semen Armeniacae Amarum, Radix Stemonae antiasthmatic-antitussive; Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis tonifying the lung yin fluid astringing, Qi-benefiting and heart-nourishing; Borneolum Syntheticum can be warded off and dirtyly have one's ideas straightened out.Produce synergism after making these drug regimens, can more effectively treat pulmonary heart disease and by its sequela that causes.Took 10 days, feeling more than 52% takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Took 50 days, feeling more than 75% takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Took 100 days, feeling more than 98% takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and the blood supply of electrocardio diagram coronary artery obviously improves, the recovery from illness of some patients were self-induction.Take in experimental group more than 100 days, effective percentage can reach more than 93%, and matched group mostly is 80% most.
The application's prescription is the distinguished veteran doctors of TCM proved recipe, and has passed through Liaocheng University, Liaocheng City experts and scholars' of the hospital of traditional Chinese hospital demonstration, has the prospect of industrialized implementation.The present inventor is the Shandong employee of the institute of political science and law (speaker's inventive science), and completing of this invention has benefited from Shandong Province's 12 Planning emphasis subjects---the support of Law of Economy subject fund.
Should be pointed out that the specific embodiment is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, and a lot of distortion can also be arranged.Those of ordinary skill in the art, with the present invention clear and definite disclosed or undoubted according to the written description of file obtaining, all should think the claimed scope of this patent.
Claims (9)
1. the preparation method of the Chinese medicine preparation water preparation for the treatment of pulmonary heart disease, is characterized in that, takes off the row crude drug, be weight portion: Semen Coicis 20-45, Rhizoma Phragmitis 20-45, Semen Persicae 6-12, Semen Benincasae 20-45, Pumex 20-45, Semen Trichosanthis 20-26, Semen Lepidii (Semen Descurainiae) 20-30, Radix Stemonae 6-12, Semen Armeniacae Amarum 6-15, Radix Ginseng 2-6, Radix Ophiopogonis 12-25, Fructus Schisandrae Chinensis 3-9, Bulbus Fritillariae Uninbracteatae 6-12, Rhizoma Anemarrhenae 10-20, Borneolum Syntheticum 0.02-0.3; Step is:
(1) Semen Coicis, Rhizoma Phragmitis, Semen Persicae, Semen Benincasae, Pumex, Semen Trichosanthis, Semen Lepidii (Semen Descurainiae), the Radix Stemonae, Semen Armeniacae Amarum, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Bulbus Fritillariae Uninbracteatae and the Rhizoma Anemarrhenae are pulverized, crossed the 120-140 mesh sieve, get fine powder;
(2) with step (1) gained fine powder mix homogeneously, be placed in penetrating bag, be that the cold water of 20-40 ℃ soaked 6-8 hour with temperature, water consumption is 3-4 times of described fine powder weight;
(3) be heated to boiling, continue to take out penetrating bag after 0.6-1.2 hour, gained liquid gets concentrated solution through being concentrated into the 1/2-1/3 of original volume;
(4) will add in the concentrated solution of step (3) gained after the Borneolum Syntheticum grinding, sterile packaged namely gets the Chinese medicine preparation water preparation.
2. preparation method according to claim 1, is characterized in that, step (1) is crossed 130 mesh sieves, gets fine powder.
3. preparation method according to claim 1, is characterized in that, step (2) is the cold water immersion of 30 ℃ with temperature.
4. preparation method according to claim 1, is characterized in that, step (2) soak time 7 hours.
5. preparation method according to claim 1, is characterized in that, step (2) water consumption is 3.5 times of described fine powder weight.
6. preparation method according to claim 1, is characterized in that, step (3) continues to take out after 0.8-1.0 hour penetrating bag.
7. preparation method according to claim 1, is characterized in that, Semen Coicis 25-35, Rhizoma Phragmitis 25-35, Semen Persicae 9-10, Semen Benincasae 25-35, Pumex 25-35, Semen Trichosanthis 22-24, Semen Lepidii (Semen Descurainiae) 22-28, Radix Stemonae 9-10, Semen Armeniacae Amarum 9-12, Radix Ginseng 3-5, Radix Ophiopogonis 15-20, Fructus Schisandrae Chinensis 5-8, Bulbus Fritillariae Uninbracteatae 9-10, Rhizoma Anemarrhenae 12-15, Borneolum Syntheticum 0.08-0.2.
8. preparation method according to claim 7, is characterized in that, Borneolum Syntheticum 0.1-0.15.
9. preparation method according to claim 1, is characterized in that, Semen Coicis 30, Rhizoma Phragmitis 30, Semen Persicae 9.5, Semen Benincasae 30, Pumex 30, Semen Trichosanthis 23, Semen Lepidii (Semen Descurainiae) 26, the Radix Stemonae 9.5, Semen Armeniacae Amarum 10, Radix Ginseng 4, Radix Ophiopogonis 18, Fructus Schisandrae Chinensis 6, Bulbus Fritillariae Uninbracteatae 9.5, the Rhizoma Anemarrhenae 13, Borneolum Syntheticum 0.12.
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