CN1119107A - Medicine for curing diseases of respiratory system, esp. bronchial asthma and preparing process thereof - Google Patents
Medicine for curing diseases of respiratory system, esp. bronchial asthma and preparing process thereof Download PDFInfo
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Abstract
The medicine in the form of tincture, powder, or oral liquor for curing asthma, tracheitis, bronchitis, pneumonectasis, etc. with high cure rate, quick action, low cost and no toxic by-effect features that bamboo aphid is its main component basically.
Description
The present invention relates to treatment medicine of a kind of asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease and preparation method thereof, particularly relating to bamboo aphid or with the bamboo aphid is treatment medicine of principal agent treatment asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease and preparation method thereof.Belong to pharmaceutical sanitary field.
The traditional Chinese medical science adopts plant amedica treatment disease more, and it is less to make medical material treatment disease with animal, makes medical material treatment disease then still less with insecticide.Patent and a large amount of medical literature by retrieval, medicine of identical with the present invention treatment asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease and preparation method thereof is disclosed or public use before the present invention.Asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease are commonly encountered diseases, frequently-occurring disease, all belong to respiratory system disease.Asthma, tracheitis, bronchitis develop into the serious stage, can cause emphysema, pulmonary heart disease, by can reach the purpose of treatment emphysema, pulmonary heart disease to asthma, tracheitis, bronchitic treatment.Existing Chinese patent medicine is generally used GUILONG KECHUANNING, kidney and relieve asthma sheet, Radix Stemonae (processed) electuary, compound recipe Rhizoma Seu Herba Bergeniae sheet, Syrupus Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae is treated, its weak point is a unsatisfactory curative effect, the course of treatment is long, be difficult to radical cure, the medicine that is applicable to acute attack stage can not be taken into account the catabasis, is applicable to that paracmastic medicine can not take into account acute attack stage again.Western medicine generally adopts aminophylline, terbutaline, anticol, penicillin, josamycin to wait and treats, its weak point be difficult to radical cure, the catabasis takes and has little effect, what have goes back toxic side effect, as ammonia bitter edible plant alkali, rich agent health Buddhist nun hepatic and renal function there is infringement, penicillin then allergy sufferers can not use, and a lot of pharmaceutical production method complexity, the cost height.
The objective of the invention is to avoid the above-mentioned weak point of prior art and provide a kind of can radical cure, and radical rate height takes effect rapidly, both has been applicable to acute attack stage, is applicable to the catabasis again, short treating period, cost is low, technology is simple, the medicine that has no side effect.
The present invention can realize by following measure:
A kind of medicine for the treatment of asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease, its special character is that this medicine is made up of bamboo aphid basically, and limited component that other are not pointed out and content thereof are to the not influence in fact of basic medicinal characteristic of pointed bamboo aphid component.Oral administration dosage: make tincture, each 30 milliliters, every day three times; Make powder, each 0.3-5 gram, every day three times; Make proportion and be 1.15 oral liquid, each 5-10 milliliter, every day three times.
Its preparation method is as follows:
1, several steps is in the following order made tincture
Bamboo aphid is added water, squeeze juice, filter,, boil, cooling with rice wine.The part by weight of bamboo aphid, water and rice wine is 12-20%, 62-70%, 12-20%.
Oral administration dosage: each 30 milliliters, every day three times.
2, several steps is in the following order made powder
Bamboo aphid is dried quick-fried with 60 ℃, pulverize, cross 0.15 mm sieve, make the powder finished product.
Oral administration dosage: each 0.3-5 gram, every day three times.
3, several steps is in the following order made oral liquid
With 60 ℃ of dryings, coarse pulverization adds six times of decoctings and endures with bamboo aphid, filter, add three times of decoctings again and endure, filter, it is 1.15 extractum that medicinal liquid is condensed into proportion, add 90% above dissolve with ethanol active ingredient, behind the filtering-depositing, medicinal liquid is inserted vacuum concentration pot reclaim ethanol, with flavoring agent, antiseptic, be made into proportion and be 1.15 liquid, oral liquid is made in fill.
Oral administration dosage: each 5-10 milliliter, every day three times.
Also can be made into tablet, capsule, tincture, unguentum and spray with former prescription and consumption.
The present invention can also realize by following measure:
A kind of medicine for the treatment of asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease, its special character is that this medicine is principal agent with the bamboo aphid, be aided with Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) and make compound preparation, the ratio of bamboo aphid shared weight in this prescription is 40%-60%, the ratio of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) shared weight in this prescription is 40%-60%, oral administration dosage: make powder, each 0.8-8 gram, every day three times; Make proportion and be 1.15 oral liquid, each 2-20 milliliter, every day three times.
Its preparation method is as follows:
1, several steps is in the following order made powder
Bamboo aphid with 60 ℃ of dryings, is pulverized, standby; Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) with 80 ℃ of dryings, is pulverized,, pulverized, cross 0.15 mm sieve, make several doses of finished products with the bamboo aphid dry powder blend.
Oral administration dosage: each 0.8-8 gram, every day three times.
2, several steps is in the following order made oral liquid
With bamboo aphid, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) coarse pulverization, add six times of decoctings and endure, filter, add three times of decoctings again and endure, filter, it is 1.15 extractum that medicinal liquid is condensed into proportion, adds 90% above dissolve with ethanol effective ingredient, behind the filtering-depositing, medicinal liquid is inserted vacuum concentration pot reclaim ethanol, with flavoring agent, antiseptic, be made into proportion and be 1.15 liquid, fill becomes the oral liquid finished product.
Oral administration dosage: each 10-20 milliliter, every day three times.
Also can be made into tablet, capsule, tincture, unguentum and spray with former prescription and consumption.
The present invention can also realize by following measure:
A kind of medicine for the treatment of asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease, its special character is that this medicine is principal agent with the bamboo aphid, be aided with Herba Ephedrae, Ramulus Cinnamomi, Semen Armeniacae Amarum, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Fructus Perillae, Pericarpium Citri Reticulatae, Radix Asteris, Radix Glycyrrhizae composition, the ratio of bamboo aphid shared weight in this prescription is 5%-30%, Herba Ephedrae, Ramulus Cinnamomi, Semen Armeniacae Amarum, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Fructus Perillae, Pericarpium Citri Reticulatae, Radix Asteris, Radix Glycyrrhizae were in 1: 1: 1: 1: 1: 1: 1: 0.5 ratio is formed, and the ratio of shared weight is 70%-95% in this prescription.Oral administration dosage: make powder, each 6-16 gram, every day three times; Make proportion and be 1.15 oral liquid, each 10-30 milliliter, every day three times.
Its preparation method is as follows:
1, several steps is in the following order made powder
With bamboo aphid, Ramulus Cinnamomi, Fructus Perillae, Pericarpium Citri Reticulatae with 60 ℃ of dryings, coarse pulverization, standby; Semen Armeniacae Amarum, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Ephedrae, Radix Asteris, Radix Glycyrrhizae with 80 ℃ of dryings, are pulverized, cross 0.15 mm sieve,, pulverize, cross 0.15 mm sieve, make several doses of finished products with bamboo aphid, Ramulus Cinnamomi, Fructus Perillae, Pericarpium Citri Reticulatae dry powder blend.
Oral administration dosage: each 6-16 gram, every day three times.
2, several steps is in the following order made oral liquid
With bamboo aphid, Herba Ephedrae, Ramulus Cinnamomi, Semen Armeniacae Amarum, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Fructus Perillae, Pericarpium Citri Reticulatae, Radix Asteris, Radix Glycyrrhizae coarse pulverization, add six times of decoctings and endure, filter, add three times of decoctings again and endure, filter, it is 1.15 extractum that medicinal liquid is condensed into proportion, adds 90% above dissolve with ethanol active ingredient, behind the filtering-depositing, medicinal liquid is inserted vacuum concentration pot reclaim ethanol, with flavoring agent, antiseptic, be made into proportion and be 1.15 liquid, fill becomes the oral liquid finished product.
Oral administration dosage: each 10-30 milliliter, every day three times.
Also can be made into tablet, capsule, tincture, unguentum and spray with former prescription and consumption.
The present invention can also realize by following measure:
A kind of medicine for the treatment of asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease, its special character is that this medicine is principal agent with the bamboo aphid, be aided with Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, the Rhizoma Anemarrhenae, Sang Baipi, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Glycyrrhizae composition, the ratio of bamboo aphid shared weight in this prescription is 5%-30%, Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, the Rhizoma Anemarrhenae, Sang Baipi, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Glycyrrhizae were in 1: 1: 2: 1: 1: 1: 0.5 ratio is formed, and the ratio of shared weight is 70%-95% in this prescription.Oral administration dosage: make powder, each 6-16 gram, every day three times; Make proportion and be 1.15 oral liquid, each 10-30 milliliter, every day three times.
Its preparation method is as follows:
1, several steps is in the following order made powder
With 60 ℃ of dryings, coarse pulverization is standby with bamboo aphid, Gypsum Fibrosum; Semen Armeniacae Amarum, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Ephedrae, the Rhizoma Anemarrhenae, Cortex Mori, Radix Glycyrrhizae cross 0.15 mm sieve with 80 ℃ of dryings, with bamboo aphid, Gypsum Fibrosum dry powder blend, pulverize, and cross 0.15 mm sieve, make the powder finished product.
Oral administration dosage: each 6-16 gram, every day three times.
2, several steps is in the following order made oral liquid
With bamboo aphid, Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, the Rhizoma Anemarrhenae, Sang Baipi, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Glycyrrhizae coarse pulverization, add six times of decoctings and endure, filter, add three times of decoctings again and endure, filter, it is 1.15 extractum that medicinal liquid is condensed into proportion, adds 90% above dissolve with ethanol active ingredient, behind the filtering-depositing, medicinal liquid is inserted vacuum concentration pot reclaim ethanol, with flavoring agent, antiseptic, be made into proportion and be 1.15 liquid, the oral liquid finished product is made in fill.
Oral administration dosage: each 10-30 milliliter, every day three times.
With former prescription and consumption also can be made into tablet, capsule,, tincture, unguentum and spray.
The present invention can also realize by following measure:
A kind of medicine for the treatment of asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease, its special character is that this medicine is principal agent with the bamboo aphid, be aided with Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) composition, the ratio of bamboo aphid shared weight in this prescription is 5%-30%, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) were in 1: 1: 1: 1 ratio is formed, and the ratio of shared weight is 70%-95% in this prescription.Oral administration dosage: make powder, each 6-16 gram, every day three times; Make proportion and be 1.15 oral liquid, each 10-30 milliliter, every day three times.
Its preparation method is as follows:
1, several steps is in the following order made powder
With bamboo aphid with 60 ℃ of dryings, coarse pulverization, standby; Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) with 80 ℃ of dryings, are pulverized, crossed 0.15 mm sieve,, pulverize, cross 0.15 mm sieve, make the powder finished product with the bamboo aphid dry powder blend.
Oral administration dosage: each 6-16 gram, every day three times.
2, several steps is in the following order made oral liquid
With bamboo aphid, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) coarse pulverization, add six times of decoctings and endure, filter, add three times of decoctings again and endure, filter, it is 1.15 extractum that medicinal liquid is condensed into proportion, adds 90% above dissolve with ethanol active ingredient, behind the filtering-depositing, medicinal liquid is inserted vacuum concentration pot reclaim ethanol, with flavoring agent, antiseptic, be made into proportion and be 1.15 liquid, the oral liquid finished product is made in fill.
Oral administration dosage: each 10-30 milliliter, every day three times.
Also can be made into tablet, capsule, tincture, unguentum and spray with former prescription and consumption.
The present invention can also realize by following measure:
A kind of treatment asthma, tracheitis, bronchitis, emphysema, the medicine of pulmonary heart disease, its special character is that this medicine is principal agent with the bamboo aphid, be aided with Gecko, Semen Armeniacae Amarum, Radix Glycyrrhizae, Radix Ginseng, Poria, Bulbus Fritillariae Uninbracteatae, Cortex Mori, the Rhizoma Anemarrhenae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is formed, the ratio of bamboo aphid shared weight in this prescription is 5%-30%, Gecko, Semen Armeniacae Amarum, Radix Glycyrrhizae, Radix Ginseng, Poria, Bulbus Fritillariae Uninbracteatae, Cortex Mori, the Rhizoma Anemarrhenae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) was in 3: 3: 3: 1: 1: 1: 1: 1: 1 ratio is formed, the ratio of shared weight is 70%-95% in this prescription, oral administration dosage is: make powder, each 6-16 gram, every day three times: make proportion and be 1.15 oral liquid, each 10-30 milliliter, every day three times.
Its preparation method is as follows:
1, several steps is in the following order made powder
Bamboo aphid, Bulbus Fritillariae Uninbracteatae, Poria with 60 ℃ of dryings, are pulverized, standby; Gecko, Semen Armeniacae Amarum, Radix Glycyrrhizae, Cortex Mori, the Rhizoma Anemarrhenae, Radix Ginseng, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) with 80 ℃ of dryings, are pulverized, crossed 0.15 mm sieve,, pulverize, cross 0.15 mm sieve, make the powder finished product with bamboo aphid, Bulbus Fritillariae Uninbracteatae, Poria dry powder blend.
Oral administration dosage: each 6-16 gram, every day three times.
2, several steps is in the following order made oral liquid
With bamboo aphid, Gecko, Semen Armeniacae Amarum, Radix Glycyrrhizae, Radix Ginseng, Poria, Bulbus Fritillariae Uninbracteatae, Cortex Mori, the Rhizoma Anemarrhenae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) coarse pulverization, add six times of decoctings and endure, filter, add three times of decoctings again and endure, filter, it is 1.15 extractum that medicinal liquid is condensed into proportion, adds 90% above dissolve with ethanol active ingredient, behind the filtering-depositing, medicinal liquid is inserted vacuum concentration pot reclaim ethanol, with flavoring agent, antiseptic, be made into proportion and be 1.15 liquid, the oral liquid finished product is made in fill.
Oral administration dosage: each 10-30 milliliter, every day three times.
Also can be made into tablet, capsule, tincture, unguentum and spray with former prescription and consumption.
The present invention can also realize by following measure:
A kind of medicine for the treatment of asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease, its special character is that this medicine is principal agent with the bamboo aphid, be aided with Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Poria, Rhizoma Alismatis, Rhizoma Dioscoreae, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) composition, the ratio of bamboo aphid shared weight in this prescription is 5%-30%.Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Poria, Rhizoma Alismatis, Rhizoma Dioscoreae, Cortex Cinnamomi, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Aconiti Lateralis Preparata were in 1: 1: 1: 1: 1: 1: 1: 1: 1 ratio is formed, and the ratio of shared weight is 70%-95% in this prescription.Oral administration dosage: make powder, each 6-16 gram, every day three times; Make proportion and be 1.15 oral liquid, each 10-30 milliliter, every day three times.
Its preparation method is as follows:
1, several steps is in the following order made powder
Bamboo aphid, Cortex Cinnamomi, Poria, Rhizoma Alismatis, Rhizoma Dioscoreae with 60 ℃ of dryings, are pulverized, standby; Cortex Moutan with 50 ℃ of dryings, is pulverized, standby; Fructus Corni, Radix Rehmanniae Preparata, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Aconiti Lateralis Preparata with 80 ℃ of dryings, are pulverized, crossed 0.15 mm sieve,, pulverize, cross 0.15 mm sieve, make the powder finished product with bamboo aphid, Cortex Cinnamomi, Poria, Rhizoma Alismatis, Rhizoma Dioscoreae, Cortex Moutan dry powder blend.
Oral administration dosage: each 6-16 gram, every day three times.
2, several steps is in the following order made oral liquid
With bamboo aphid, Cortex Cinnamomi, Fructus Corni, Poria, Rhizoma Alismatis, Rhizoma Dioscoreae, Cortex Moutan, Radix Rehmanniae Preparata, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Aconiti Lateralis Preparata coarse pulverization, add six times of decoctings and endure, filter, add three times of decoctings again and endure, filter, it is 1.15 extractum that medicinal liquid is condensed into proportion, adds 90% above dissolve with ethanol active ingredient, behind the filtering-depositing, medicinal liquid is inserted vacuum concentration pot reclaim ethanol, with flavoring agent, antiseptic, the ratio of being made into is 1.15 liquid, and the oral liquid finished product is made in fill.
Oral administration dosage: each 10-30 milliliter, every day three times.
Also can be made into tablet, capsule, tincture, unguentum and spray with former prescription and consumption.
The successive dynasties document is to put down in writing in Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica the earliest to the record of bamboo aphid seldom: " abnormal smells from the patient is poisonous, cures mainly apoplexy, and hemiplegia can saturating meridians, chase after saliva." thereafter, only have " Chinese medicine voluminous dictionary " and " Dictionary of Chinese Pharmacy " on the books, content is all quoted Compendium of Material Medica, and all thinks toxic.Since the Ming Dynasty more than 400 year, ancient Chinese medicine doctor all was confined to the record of Compendium of Material Medica to the understanding of bamboo aphid, thought that it is poisonous and was not applied, and the modern medicine document is not seen the report that holds a different view yet by retrieval.Therefore, though bamboo aphid is recorded certain medical value by Compendium of Material Medica, but it is considered to virose prejudice traditionally, hindered the further research of people to bamboo aphid treatment disease, more unmanned discussion is developed to industrial batch process with bamboo aphid, the probability of the medicine of putting on market in a large number or proposition technical scheme.The inventor at first thinks Compendium of Material Medica record bamboo aphid is virose and is based on insufficient grounds, though someone has vomiting reaction after taking bamboo aphid, but vomiting reaction is not equal to toxic reaction, and then nontoxic by evidence bamboo aphid acute toxicity and long term toxicity, solved one of prerequisite that bamboo aphid is developed to medicine-safety.Pass through pharmacodynamics test again, the proof bamboo aphid have relieving asthma, eliminate the phlegm, cough-relieving, immunity, tonification effect, not only tracheal smooth muscle is had relaxation effect, eliminate the phlegm in addition, the effect of antitussive, immunity and tonification, can treat asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease, curative effect is comprehensive.The inventor carries out some clinical verifications under the situation that underground prescription is formed, also prove evident in efficacy to above-mentioned disease.
The inventor has vomiting reaction find have few part people to take bamboo aphid in clinical observation after, and Compendium of Material Medica also has the record of " with the bamboo aphid roasting is the end, and hot wine is taken after mixing with liquid, and just crouches, and in the moment, medicine is capable of sound of the wind, mouth spue aversion to water ".Though acute toxicity and long term toxicity test proof are not toxic and side effects, but the untoward reaction that human body is safe from harm, drug withdrawal can be eliminated, but the technical scheme with diseases such as bamboo aphid single medicinal material treatment asthma also has certain limitation, can form compound recipe with other Chinese medicines, not only prevent vomiting reaction but also be applicable to the treatment of asthma to various different pattern of syndrome, tracheitis, bronchitis, emphysema, pulmonary heart disease.
The invention has the beneficial effects as follows:
The medicine of A, the treatment asthma of forming by bamboo aphid basically, tracheitis, bronchitis, emphysema, pulmonary heart disease, real through pharmacology pharmacodynamic test and clinical case 30 illustrations, this medicine and existing medicine for the treatment of above-mentioned disease, RUGUI dragon tetrahydro-isoquinolin is compared better efficacy, and radical rate height, instant effect both had been applicable to acute attack stage, was applicable to the catabasis again, have no side effect short treating period.
Pharmacodynamics test of the present invention is as follows:
Occupy the test of relievining asthma of the pseudo-angle of bamboo aphid powder
One, occupies of the influence of the pseudo-angle of bamboo aphid powder to the medicine guinea pig asthmatic model
Method and result
Before the experiment Cavia porcellus is put into respectively one by one by air compressor, the aerosol shower nozzle, the aerosol of the glass bell jar composition of base and four liters draws to be breathed heavily in the device.Pressure with 400mmHg sprays into 15 seconds kinds of 0.1% histamine phosphate's solution, chooses to draw and breathes heavily incubation period (beginning asthma, dyspnea to occur, fall the required time until tic to animal from spraying).Draw to breathe heavily and be qualified animal less than 120 seconds persons incubation period.Get 32 of the qualified Cavia porcelluss of screening, be divided into four groups (N=8) at random, blank group (equal-volume normal saline), GUILONG KECHUANNING group (0.3g/kg), occupy pseudo-1 group in the aphid powder in angle (0.3g/kg) of bamboo, occupy pseudo-2 groups in the aphid powder in angle (1.8g/kg) of bamboo, each treated animal every day is oral to be given and is tried thing accordingly, continuous four times, in last give tried thing 1h after, measure each treated animal incubation period with method, surpass 6 minutes persons all incubation periods, all calculated by 6 minutes, the result is as showing:
Table: occupy the pseudo-angle of bamboo aphid powder histamine is caused the influence of breathing heavily (X ± SD)
| Group | Number of animals (only) | Dosage (g/kg) | Incubation period (S) |
| The blank group | ????8 | ????138.4±16.9 | |
| The GUILONG KECHUANNING group | ????8 | ????0.3 | ????229.3±25.4** |
| Occupy 1 group in the pseudo-angle of bamboo aphid powder | ????8 | ????0.3 | ????236.6±36.4** |
| Occupy 2 groups in the pseudo-angle of bamboo aphid powder | ????8 | ????1.8 | ????297.3±101.7** |
Compare with the blank group: * * P＜0.01
As seen from table, occupy the pseudo-angle of bamboo aphid powder and can significantly suppress Cavia porcellus asthma reaction due to the histamine.
Two, occupy of the influence of the pseudo-angle of bamboo aphid powder to the isolated tracheal sheet
Method and result
Cavia porcellus is shot dead, back of the body position is fixed on the toy dissecting table, at outside of belly medisection skin of neck and subcutaneous tissue, the careful trachea that separates, take off trachea from thyroid cartilage down to the trachea crotch, put into the plate that fills gram-Heng Shi liquid, at trachea outside of belly longitudinal incision trachea, walk crosswise from the interval of three cartilaginous rings and to cut off, get three sections trachea sheets as method, every section trachea sheet is sewed on surgical thread at its longitudinal incision place, make trachea connection slip, insert in the isolated organ bath that fills gram-Heng Shi liquid, the lower end is fixed on the logical hook of " L " glass, last end line connects by on the record reaction tracing device, temperature constant is at 37 ℃, and lasting giving and oxygen and carbon dioxide gas, treats the specimen balance and stability 60-90 minutes (changing gram-Heng Shi liquid once in per 20 minutes), with the method for cumulative scale administration, observe the effect (N=10) of thing that tried then to guinea-pig isolated trachea connection slip.
The result shows, to the loose onset value 4 * 10 of guinea-pig isolated trachea connection slip
-3G/ml causes guinea-pig isolated trachea connection slip spasm antagonism value 1.4 * 10 to histamine
-2G/ml.Show that occupying the pseudo-angle of bamboo aphid powder has relaxation effect to guinea pig tracheal smooth muscle.
Occupy the aphid powder antitussive test of the pseudo-angle of bamboo
Method and result
Select 40 of mices, be divided into four groups (N=10) at random, blank group (equal-volume normal saline), GUILONG KECHUANNING group (0.3g/kg), occupy pseudo-1 group in the aphid powder in angle (0.3g/kg) of bamboo, occupy pseudo-2 groups in the aphid powder in angle (2.1g/kg) of bamboo, each treated animal every day is oral to be given and is tried thing accordingly, continuous four times, last was tried thing after one hour, and mice is placed respectively in the 500ml glass bell jar, connected the glass fog-spray nozzle by air compressor, with the 400mmHg constant voltage the 25% ammonia five seconds of spraying is equably drawn and coughs, respectively the cough latent period of each Mus of observed and recorded (beginning to occur the cough required time first) and the number of times of coughing in 2 minutes to animal from spraying.The result is as showing:
Table: occupy the pseudo-angle of bamboo aphid powder causes mouse cough to ammonia influence (X ± SD)
| Group | Number of animals (N) | Dosage (g/kg) | Cough | |
| Incubation period (S) | Number of times (2min) | |||
| The blank group | ???10 | ?????22.6±4.5 | ???29.1±2.1 | |
| The GUILONG KECHUANNING group | ???10 | ????0.3 | ?????26.4±6.6 | ???20.0±5.5* |
| Occupy 1 group of the pseudo-angle of bamboo aphid | ???10 | ????0.3 | ????40.6±9.2** | ??19.3±3.1** |
| Occupy 2 groups of the pseudo-angle of bamboo aphids | ????10 | ????2.1 | ????48.9±8.9** | ??16.6±1.9** |
Compare with the blank group: * P＜0.05 * * P＜0.01
As seen from table, occupy the pseudo-angle of bamboo aphid powder and can very significantly prolong mouse cough incubation period, reduce the cough number of times.
Occupy the pseudo-angle of bamboo aphid powder expectorant test
Method and result
Get 40 of ICR mices, be divided into four groups (N=10) at random, blank group (isometric(al) normal saline), GUILONG KECHUANNING group (0.3g/kg) occupies pseudo-1 group in the aphid powder in angle (0.3g/kg) of bamboo, occupies pseudo-2 groups in the aphid powder in angle (2.1g/kg) of bamboo.Each treated animal is irritated the corresponding thing that tried of stomach every day, successive administration three times, only injected 5% phenol red solution 0.25ml/ in last to trying 30 minutes pneumoretroperitoneums of thing, after 30 minutes,, separate trachea with sacrifice of animal, insert No. 7 syringe needle, wash trachea three times 0.5ml/ time with 5% sodium bicarbonate solution, merge flushing liquor, phenol red standard pipe colorimetric.The results are shown in Table.
Table: occupy the pseudo-angle of bamboo aphid powder to the influence of mice lavage of trachea liquid phenol red amount (X ± SD)
| Group | Number of animals (only) | Dosage (g/kg) | Phenol red output (ug/ml) |
| The blank group | ???10 | ?????0.66±0.30 | |
| The GUILONG KECHUANNING group | ???10 | ????0.3 | ????1.08±0.27** |
| Occupy 1 group in the pseudo-angle of bamboo aphid powder | ???10 | ????0.3 | ????1.13±0.33** |
| Occupy 2 groups in the pseudo-angle of bamboo aphid powder | ???10 | ????2.1 | ????1.26±0.61* |
Compare with the blank group: * P＜0.05 * * P＜0.01
As seen from table, occupy the pseudo-angle of bamboo aphid powder and can obviously increase the amount that mouse breathing road mucosa is discharged phenol red.
Occupy the pseudo-angle of bamboo aphid powder to Immune Effects
Method and result
Get 40 of SD rats, be divided into four groups at random, blank group (isometric(al) normal saline), GUILONG KECHUANNING group (0.3g/kg) occupies pseudo-1 group in the aphid powder in angle (0.3g/kg) of bamboo, occupies pseudo-2 groups in the aphid powder in angle (1.8g/kg) of bamboo.Each treated animal is irritated the corresponding thing that tried of stomach by group every day, and successive administration 12 is died young.The 13rd day, femoral vein blood, Japanese CC-180 type electronic blood cell counter is measured peripheral leukocytes, lymphocytic content; Put to death animal, cut open inspection, get thymus, spleen is weighed, and calculates organ index; The comparable group differences.See Table 1, table 2.
Table 1: occupy the pseudo-angle of bamboo aphid powder to rat immunity organ weight's influence (X ± SD)
| Group | Number of animals (only) | Dosage (g/kg) | Thymus (mg/100g body weight) |
| The blank group | ???10 | ??????84.79±14.81 | |
| The GUILONG KECHUANNING group | ???10 | ????0.3 | ?????109.46±10.22** |
| Occupy 1 group in the pseudo-angle of bamboo aphid powder | ???10 | ????0.3 | ?????109.92±7.53** |
| Occupy 2 groups in the pseudo-angle of bamboo aphid powder | ???10 | ????1.8 | ?????109.98±8.16** |
| Spleen (mg/100g body weight) |
| ????181.56±12.45 |
| ???232.38±13.33*** |
| ???241.72±14.5*** |
| ???243.51±20.80*** |
Compare with the blank group: * * P＜0.01 * * * P＜0.001
Table 2, occupy the pseudo-angle of bamboo aphid powder to the influence of rat immunity cell quantity (X ± 8D)
| Group | Number of animals (only) | Dosage (g/kg) | Leukocyte (* 10 9/L) |
| The blank group | ???10 | ?????8.27±1.89 | |
| The GUILONG KECHUANNING group | ???10 | ????0.3 | ?????9.03±1.48 |
| Occupy 1 group in the pseudo-angle of bamboo aphid powder | ???10 | ????0.3 | ?????8.44±1.81 |
| Occupy 2 groups in the pseudo-angle of bamboo aphid powder | ???10 | ????1.8 | ????13.87±4.13** |
| Lymphocyte (%) |
| ????74.7±7.97 |
| ????78.8±7.86 |
| ????74.1±11.86 |
| ????82.8±4.18* |
Compare with the blank group: * P＜0.05 * * P＜0.01; Compare with the GUILONG KECHUANNING group: Δ Δ P＜0.01
By table 1, table 2 as can be known, occupy the pseudo-angle of bamboo aphid powder the rat immunity of increasing organ weight, rising periphery WBC, lymphocytic effect are arranged.
Conclusion: occupy the pseudo-angle of bamboo aphid powder have relieving asthma, antitussive, eliminate the phlegm, the effect of raise immunity.
Occupy of the acute toxicity test of the pseudo-angle of bamboo aphid powder to mice
Method and result
1, oral medicated powder MTD measures
Get 20 of ICR mices, male and female half and half are received in the mice mouth stomach with 0.025g/10g medicated powder and are raised, and three times on the one, total dosage 0.15g/20g.Observed seven continuously.
As a result, each animal does not see whole body poisoning manifestations and death.By no abnormality seens such as hair, the colour of skin, breathing, nose, eye, oral cavity, outward appearance behavior, the mental status, food rations.Put to death animal after seven days and cut open inspection, also no abnormality seen.
2, oral liquid medicine MTD measures
Get 20 ICR mices, male and female half and half, every of the medicine liquid irrigation stomach 0.4ml/10g/ with 20%, three times on the one, total dosage 0.48g/20g.Observed seven continuously.
As a result, each Mus does not see whole body toxic reaction performance and death condition.By no abnormality seens such as hair, skin, mucosa, breathing, central nervous system, extremity activity, outward appearance behavior and food rations.Put to death each Mus after seven days and carry out system's dissection one by one, as seen no abnormal.
Conclusion
Raise administration for the mice stomach, occupy the pseudo-angle of bamboo aphid powder consumption and reach 125 times of day for human beings clothes 3 gram consumptions, occupy the pseudo-angle of bamboo aphid powder boiled water and take after mixing it with water and irritate stomach and reach 400 times of day for human beings clothes 3 gram consumptions, do not see animal dead and toxic reaction, oral safety take place.
Occupy the long term toxicity test of the pseudo-angle of bamboo aphid powder to rat
Method and result
1, method
Get 80 of SD rats, male and female half and half are divided into four groups at random, 20 every group.First three groups is respectively high, medium and low three kinds of dosed administration groups, irritates stomach dosage every day and is: high dose group 3ml/200g (3g/kg); Middle dosage group 2.4ml/200g (2.4g/kg); Low dose group 1.2ml/200g (1.2g/kg).The 4th group is the blank group, irritates stomach isometric(al) distilled water 1.2ml/200g.Successive administration 24 days.Day by day observed and recorded animal general state was weighed once in per 6 days.The 25th, femoral vein blood carried out hemogram (RBC, Hgb, WBC and DC counting) and liver function (SGPT, TT) and kidney merit (B-UN, Cr) and checks; Put to death, core, lung, liver,spleen,kidney weigh, and calculates organ coefficient; And core, each one in lung, liver,spleen,kidney, stomach, intestinal tissue, 10% formalin is fixed, paraffin embedding, HE dyeing, optical microscope is observed down.
2, result:
(1), general state observes: administration group and matched group relatively, do not see that animal screams, uneasiness, tremble, faint from fear, benumb, have a liking for saliva, sialorrhea, dyspnea, toxic reaction such as become thin.
(2), to the influence of the weight of animals: in the administration, low dose group, administration can obviously increase the weight of animals after 12 days, and is remarkable with the matched group comparing difference, and heavy dose of group increases no significant difference day by day with the control animals body weight.See table 1 for details.
Table 1: occupy the pseudo-angle of bamboo aphid powder to the influence of rat body weight (gram) (X ± SD)
| Group | Before the administration | Administration 6 days |
| The blank group | ??192.3±11.07 | ??195.55±11.62 |
| Low dose group | ????195±7.96 | ???205.2±9.84 |
| Middle dosage group | ?189.95±14.13 | ??204.35±16.12 |
| High dose group | ?198.05±14.15 | ??201.95±17.29 |
| Administration 12 days | Administration 18 days | Administration 24 days |
| ???198.75±13.98 | ???206.05±15.46 | ??201.6±16.95 |
| ???212.9±13.28* | ???218.6±13.03* | ??226.4±15.17* |
| ????219±17.63* | ???222.4±15.51* | ??226.3±15.26* |
| ???207.05±21.07 | ???211.7±21.13 | ??215.05±22.52 |
* compare with matched group: P＜0.05
(3), to the influence of rat main organs weight: administration height, middle dosage group, spleen organ index and matched group comparing difference are obvious, surplus person respectively organizes relatively no significant difference of each organ weights and matched group, sees row 2 for details.Table 2: occupy the pseudo-angle of bamboo aphid powder to the influence of rat main organs weight (g/100g) (X ±
SD)
| Group | The heart | Lung | Liver |
| Matched group | ??0.50±0.03 | ???0.85±0.04 | ??5.45±0.27 |
| Low dose group | ??0.49±0.02 | ???0.82±0.03 | ??5.23±0.30 |
| Middle dosage group | ??0.50±0.23 | ???0.82±0.04 | ??5.41±0.26 |
| High dose group | ??0.51±0.04 | ???0.81±0.09 | ??5.53±0.42 |
| Spleen | Kidney |
| ????0.23±0.02 | ????1.21±0.07 |
| ????0.23±0.02 | ????1.16±0.04 |
| ????0.25±0.02* | ????1.18±0.05* |
| ????0.25±0.02* | ????1.19±0.10 |
* compare with matched group: P＜0.05
(4), to the influence of rat hemogram: conventional hemogram checking shows, successive administration 24 days, middle dosage group WBC counting, lymphocyte differential counting are apparently higher than matched group, surplus person does not all have significant change.See table 3 for details.
Table 3: occupy the pseudo-angle of bamboo aphid powder to the influence of rat hemogram (X ± SD)
| Group | Erythrocyte (* 10 12/L) | Hemoglobin (g/L) | Leukocyte (* 10 9/L) |
| The blank group | ??7.69±0.58 | ???155±15.63 | ?????7.53±2.55 |
| Low dose group | ??8.10±0.31 | ???156±7.58 | ?????9.36±2.47 |
| Middle dosage group | ??7.77±0.44 | ????153±7.45 | ????13.86±4.93** |
| High dose group | ??7.99±0.33 | ??161.35±8.98 | ?????9.72±2.33 |
| Neutrophilic granulocyte (%) | Lymphocyte (%) |
| ??22.95±7.09 | ??76.53±7.08 |
| ??24.2±13.70 | ??75.8±13.7 |
| ??17.00±5.96 | ??83±5.96* |
| ??19.45±8.88 | ??80.35±8.86 |
Compare with matched group: * P＜0.05, * * P＜0.01
(5), to the influence of rat liver function, kidney merit: produce SP-501 type semi-automatic biochemical analyzer with the U.S. and measure liver function, kidney merit, the result shows that successive administration 24 is died young, administration group liver function, kidney merit and matched group comparison, all no significant difference sees table 4 for details.
Table 4: occupy the pseudo-angle of bamboo aphid powder to the influence of rat liver function, kidney merit (X ± SD)
| Group | ???SGPT(μ) | ????TT(μ) | ???BUN(umol/L) |
| Matched group | ?11.05±6.72 | ???2.4±0.59 | ???9.16±1.11 |
| Low dose group | ?13.6±11.93 | ???2.2±0.45 | ???10.22±2 |
| Middle dosage group | ?14±4.42 | ???2.8±0.84 | ???8.47±0.98 |
| High dose group | ?16.4±11.96 | ???2.3±0.57 | ???12.40±5.92 |
| ???Cr(umol/L) |
| ??147.75±16.86 |
| ??164.4±20.13 |
| ??135.4±19.71 |
| ??184.74±76.36 |
(6), to rat main organs pathological study: each organs and tissues of perusal, do not see unusual performance such as hyperemia, swelling and necrosis.The histological examination of the main organs heart, lung, liver,spleen,kidney, harmonization of the stomach intestinal, no abnormality seen atrophy, hypertrophy and inflammatory cell infiltration, each administration group and matched group be zero difference relatively.
Conclusion
1, occupies the pseudo-angle aphid powder 3g/kg of bamboo (be equivalent to Coming-of-Age Day dose 3 grams 50 times), 2.4g/kg (be equivalent to Coming-of-Age Day dose 3 grams 40 times), 1.2g/kg (be equivalent to Coming-of-Age Day clothes 3 gram consumptions 20 times), gastric infusion 24 is died young continuously, to rat growthing development, hemopoietic function, liver function and renal function free of toxic effects, to the rat heart, lung, liver,spleen,kidney, stomach, the infringement of intestinal avirulence.Show that occupying the pseudo-angle of bamboo aphid powder takes safety.
2, this test is also observed and is occupied the pseudo-angle of bamboo aphid powder and have the peripheral leukocytes of increasing, lymphocyte, the enhancing external immune organ-effect of spleen immunologic function and the benefiting action of weight increase.
B, be principal agent with the bamboo aphid, the medicine that is aided with treatment asthma that Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) forms, tracheitis, bronchitis, emphysema, pulmonary heart disease, because Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) function normalizing the stomach by guiding QI downward, can prevent vomiting, the effect that has drying dampness to eliminate phlegm, cough-relieving again, therefore with the bamboo aphid compatibility, curative effect can be increased, vomiting reaction can be prevented again.Through clinical 30 example checkings, the good effect of treatment asthma, cough, and none symptoms of emesis occurs.
C, be principal agent, be aided with a respectively: Herba Ephedrae, Ramulus Cinnamomi, Semen Armeniacae Amarum, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Fructus Perillae, Pericarpium Citri Reticulatae, Radix Asteris, Radix Glycyrrhizae with the bamboo aphid; B: Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, the Rhizoma Anemarrhenae, Cortex Mori, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Glycyrrhizae; C: Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens); D: Gecko, Semen Armeniacae Amarum, Radix Glycyrrhizae, Radix Ginseng, Poria, Bulbus Fritillariae Uninbracteatae, Cortex Mori, the Rhizoma Anemarrhenae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens); E: the medicine of the treatment asthma that Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Poria, Rhizoma Alismatis, Rhizoma Dioscoreae, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) are formed, tracheitis, bronchitis, emphysema, pulmonary heart disease:
Herba Ephedrae, Ramulus Cinnamomi lung qi dispersing expelling cold and relieving exterior syndrome, Semen Armeniacae Amarum, the Radix Glycyrrhizae promoting the circulation of QI that reduces phlegm, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) removes expectorant, sending down the abnormal ascending QI, and Fructus Perillae, Radix Asteris are eliminated the phlegm, and add Pericarpium Citri Reticulatae and regulate the flow of vital energy, and be with the bamboo aphid compatibility, through 15 routine clinical verifications, evident in efficacy to wind-cold affecting lung asthma.
It is cold that Herba Ephedrae is closed the suffering of Gypsum Fibrosum, play clearly altogether in the effect of this table, depressed lung-energy dispersing, Semen Armeniacae Amarum, the Radix Glycyrrhizae promoting the circulation of QI that reduces phlegm, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) eliminates the phlegm, sending down the abnormal ascending QI, and the Rhizoma Anemarrhenae, Cortex Mori help the merit of its removing heat-phlegm, with the bamboo aphid compatibility, through 15 routine clinical verifications, evident in efficacy to exterior cold and interior heat asthma.
The Radix Ginseng invigorating the lung and benefiting vital QI, nourishing YIN Radix Ophiopogonis, Fructus Schisandrae Chinensis is held back the receipts lung qi, and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) eliminates the phlegm, sending down the abnormal ascending QI, and is with the bamboo aphid compatibility, through 15 routine clinical verifications, evident in efficacy to deficiency of the lung asthma.
The Gecko improving inspiration by invigorating the kidney, Radix Ginseng invigorating primordial QI lung benefiting spleen, the eliminating dampness by diuresis of Poria strengthening the spleen, Cortex Mori, the sharp lung qi of Semen Armeniacae Amarum, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) eliminates the phlegm, sending down the abnormal ascending QI, the Bulbus Fritillariae Uninbracteatae clearing heat and moistening lung, Rhizoma Anemarrhenae nourishing kidney improving inspiration by invigorating kidney-QI, with the bamboo aphid compatibility,, evident in efficacy to deficiency of the lung asthma through 15 routine clinical verifications.
The Radix Rehmanniae Preparata tonifying kidney-yin, Fructus Corni, Rhizoma Dioscoreae be the tonifying liver spleen now, Ramulus Cinnamomi, Radix Aconiti Lateralis Preparata kidney-replenishing, Rhizoma Alismatis, Poria promoting diuresis to eliminate damp pathogen, Cortex Moutan removing fire from the liver, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) eliminate the phlegm, sending down the abnormal ascending QI, and be with the bamboo aphid compatibility, through 15 routine clinical verifications, evident in efficacy to the asthma of suffering from a deficiency of the kidney.
Cost of the present invention is low, and technology is simple.The principal agent bamboo aphid is the bamboo class pest, and raised growth is on the bamboo stalk of all kinds of bamboos, and the medicine source is wide, and it is convenient to catch, and production method is general production technology, and equipment is simple, and cost is low.
The bamboo aphid of indication for the host is the aphid of bamboo can be among the present invention:
Insecta, Homoptera, Aphidiadae occupies the pseudo-angle of bamboo Aphis, occupies the pseudo-angle aphid Pseudoregma bambusicold of bamboo
Insecta, Homoptera, Aphidiadae, dance Aphis, bamboo dance aphid Astegopteryxbambusifoliae
Insecta, Homoptera, Aphidiadae, protruding lip speckle Aphis, the protruding lip speckle of bamboo shoot aphid Takecallis taiwanus
Insecta, Homoptera, Aphidiadae, protruding lip speckle Aphis, bamboo is indulged speckle aphid Takecallis arundinariae
Insecta, Homoptera, Aphidiadae, bamboo color Aphis, bamboo color aphid Melanaphisbambusae
Preferred forms is:
1, will occupy the pseudo-angle of bamboo aphid 200 grams with 60 ℃ of dryings, pulverize, cross 0.15 mm sieve, make several doses, oral administration dosage: each 1.2 grams, every day three times.
2, will occupy the pseudo-angle of bamboo aphid 200 grams with 60 ℃ of dryings, pulverize, standby; Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) with 80 ℃ of dryings, is pulverized, and occupied the pseudo-angle of bamboo aphid dry powder blend, pulverize, cross 0.15 mm sieve, make powder, oral administration dosage: each 2 grams, every day three times.
3, will occupy the pseudo-angle of bamboo aphid 200 grams, Ramulus Cinnamomi 100 grams, Fructus Perillae 100 grams, Pericarpium Citri Reticulatae 100 grams with 60 ℃ of dryings, coarse pulverization, standby; Semen Armeniacae Amarum 100 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 100 grams, Herba Ephedrae 100 grams, Radix Asteris 100 grams, Radix Glycyrrhizae 50 grams with 80 ℃ of dryings, are pulverized, crossed 0.15 mm sieve, with bamboo aphid, Ramulus Cinnamomi, Fructus Perillae, Pericarpium Citri Reticulatae dry powder blend, pulverize, cross 0.15 mm sieve, make powder, oral administration dosage: each 6 grams, every day three times.
4, will occupy the pseudo-angle of bamboo aphid 200 grams, Gypsum Fibrosum 200 grams do with 60 ℃ quick-fried, coarse pulverization, standby; Semen Armeniacae Amarum 100 gram, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 100 grams, Herba Ephedrae 100 grams, the Rhizoma Anemarrhenae 100 grams, Cortex Mori 100 grams, Radix Glycyrrhizae 50 grams are crossed 0.15 mm sieve with 80 ℃ of dryings, and occupy the pseudo-angle of bamboo aphid, Gypsum Fibrosum dry powder blend, pulverize, cross 0.15 mm sieve, make several doses, oral administration dosage: each 9.5 grams, every day three times.
5, will occupy the pseudo-angle of bamboo aphid 100 grams with 60 ℃ of dryings, coarse pulverization, standby; With Radix Ginseng 100 gram, Radix Ophiopogonis 100 gram, Fructus Schisandrae Chinensis 100 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 100 grams with 80 ℃ of dryings, pulverize, cross 0.15 mm sieve, with the bamboo aphid dry powder blend, pulverize, cross 0.15 mm sieve, make powder, oral administration dosage: each 6 grams, every day three times.
6, will occupy the pseudo-angle of bamboo aphid 200 grams, Bulbus Fritillariae Uninbracteatae 60 grams, Poria 60 grams with 60 ℃ of dryings, pulverize, standby; With Gecko 150 gram, Semen Armeniacae Amarum 150 grams, Radix Glycyrrhizae 150 grams, Cortex Mori 60 grams, the Rhizoma Anemarrhenae 60 grams, Radix Ginseng 60 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 60 grams with 80 ℃ of dryings, pulverize, cross 0.15 mm sieve, with occupy the pseudo-angle of bamboo aphid, Bulbus Fritillariae Uninbracteatae, Poria dry powder blend, pulverize, cross 0.15 mm sieve, make powder, oral administration dosage: each 6 grams, every day three times.
7, will occupy the pseudo-angle of bamboo aphid 200 grams, Cortex Cinnamomi 100 grams, Poria 100 grams, Rhizoma Alismatis 100 grams, Rhizoma Dioscoreae 100 grams with 60 ℃ of dryings, pulverize, standby; Cortex Moutan 100 grams with 50 ℃ of dryings, are pulverized, standby; Fructus Corni 100 grams, Radix Rehmanniae Preparata 100 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 100 grams, Radix Aconiti Lateralis Preparata 100 are restrained with 80 ℃ of dryings, pulverize, cross 0.15 mm sieve, with occupy the pseudo-angle of bamboo aphid, Cortex Cinnamomi, Poria, Rhizoma Alismatis, Rhizoma Dioscoreae, Cortex Moutan dry powder blend, pulverize, cross 0.15 mm sieve, make powder, oral administration dosage: each 6 grams, every day three times.
Embodiment one:
Bamboo aphid 400 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 600 grams are made powder, oral administration dosage: each 0.8 gram, every day three times.
Embodiment two:
Bamboo aphid 500 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 500 grams are made powder, oral administration dosage: each 4 grams, every day three times.
Embodiment three:
Bamboo aphid 600 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 400 grams are made powder, oral administration dosage: each 8 grams, every day three times.
Embodiment four:
Bamboo aphid 395 grams, Herba Ephedrae 1000 grams, Ramulus Cinnamomi 1000 grams, Semen Armeniacae Amarum 1000 grams, Fructus Perillae 1000 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 1000 grams, Pericarpium Citri Reticulatae 1000 grams, Radix Asteris 1000 grams, Radix Glycyrrhizae 500 grams are made powder, oral administration dosage: each 6 grams, every day three times.
Embodiment five:
Bamboo aphid 662 grams, Herba Ephedrae 500 grams, Ramulus Cinnamomi 500 grams, Semen Armeniacae Amarum 500 grams, Fructus Perillae 500 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 500 grams, Pericarpium Citri Reticulatae 500 grams, Radix Asteris 500 grams, Radix Glycyrrhizae 250 grams are made powder, oral administration dosage: each 10 grams, every day three times.
Embodiment six:
Bamboo aphid 643 grams, Herba Ephedrae 200 grams, Ramulus Cinnamomi 200 grams, Semen Armeniacae Amarum 200 grams, Fructus Perillae 200 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 200 grams, Pericarpium Citri Reticulatae 200 grams, Radix Asteris 200 grams, Radix Glycyrrhizae 100 grams are made powder, oral administration dosage: each 16 grams, every day three times.
Embodiment seven:
Bamboo aphid 395 grams, Herba Ephedrae 1000 grams, Semen Armeniacae Amarum 1000 grams, Gypsum Fibrosum 2000 grams, the Rhizoma Anemarrhenae 1000 grams, Cortex Mori 1000 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 1000 grams, Radix Glycyrrhizae 500 grams are made powder, oral administration dosage: each 6 grams, every day three times.
Embodiment eight:
Bamboo aphid 662 grams, Herba Ephedrae 500 grams, Semen Armeniacae Amarum 500 grams, Gypsum Fibrosum 1000 grams, the Rhizoma Anemarrhenae 500 grams, Cortex Mori 500 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 500 grams, Radix Glycyrrhizae 250 grams are made powder, oral administration dosage: each 10 grams, every day three times.
Embodiment nine:
Bamboo aphid 643 grams, Herba Ephedrae 200 grams, Semen Armeniacae Amarum 200 grams, Gypsum Fibrosum 400 grams, the Rhizoma Anemarrhenae 200 grams, Cortex Mori 200 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 200 grams, Radix Glycyrrhizae 100 grams are made powder, oral administration dosage: each 16 grams, every day three times.
Embodiment ten:
Bamboo aphid 211 grams, Radix Ginseng 1000 grams, restrain Radix Ophiopogonis 1000, Fructus Schisandrae Chinensis 1000 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 1000 grams are made powder, oral administration dosage: each 6 grams, every day three times.
Embodiment 11:
Bamboo aphid 353 grams, Radix Ginseng 500 grams, restrain Radix Ophiopogonis 500, Fructus Schisandrae Chinensis 500 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 500 grams are made powder, oral administration dosage: each 10 grams, every day three times.
Embodiment 12:
Bamboo aphid 343 grams, Radix Ginseng 200 grams, restrain Radix Ophiopogonis 200, Fructus Schisandrae Chinensis 200 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 200 grams are made powder, oral administration dosage: each 16 grams, every day three times.
Embodiment 13:
Bamboo aphid 316 grams, Gecko 1200 grams, Semen Armeniacae Amarum 1200 grams, Radix Glycyrrhizae 1200 grams, Radix Ginseng 400 grams, Poria 400 grams, Bulbus Fritillariae Uninbracteatae 400 grams, Cortex Mori 400 grams, the Rhizoma Anemarrhenae 400 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 400 grams are made powder, oral administration dosage: each 6 grams, every day three times.
Embodiment 14:
Bamboo aphid 794 grams, Gecko 900 grams, Semen Armeniacae Amarum 900 grams, Radix Glycyrrhizae 900 grams, Radix Ginseng 300 grams, Poria 300 grams, Bulbus Fritillariae Uninbracteatae 300 grams, Cortex Mori 300 grams, the Rhizoma Anemarrhenae 300 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 300 grams are made powder, each 10 grams, every day three times.
Embodiment 15:
Bamboo aphid 643 grams, Gecko 300 grams, Semen Armeniacae Amarum 300 grams, Radix Glycyrrhizae 300 grams, Radix Ginseng 100 grams, Poria 100 grams, Bulbus Fritillariae Uninbracteatae 100 grams, Cortex Mori 100 grams, the Rhizoma Anemarrhenae 100 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 100 grams are made powder, oral administration dosage: each 16 grams, every day three times.
Embodiment 16:
Bamboo aphid 474 grams, Radix Rehmanniae Preparata 1000 grams, Fructus Corni 1000 grams, Cortex Moutan 1000 grams, Poria 1000 grams, Rhizoma Alismatis 1000 grams, Rhizoma Dioscoreae 1000 grams, Cortex Cinnamomi 1000 grams, Radix Aconiti Lateralis Preparata 1000 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 1000 grams are made powder, oral administration dosage: each 6 grams, every day three times.
Embodiment 17:
Bamboo aphid 794 grams, Radix Rehmanniae Preparata 500 grams, Fructus Corni 500 grams, Cortex Moutan 500 grams, Poria 500 grams, Rhizoma Alismatis 500 grams, Rhizoma Dioscoreae 500 grams, Cortex Cinnamomi 500 grams, Radix Aconiti Lateralis Preparata 500 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 500 grams are made powder, oral administration dosage: each 10 grams, every day three times.
Embodiment 18:
Bamboo aphid 770 grams thermally 200 restrain, Fructus Corni 200 grams, and Cortex Moutan 200 grams, Poria 200 grams, Rhizoma Alismatis 200 grams, Rhizoma Dioscoreae 200 restrains, Cortex Cinnamomi 200 grams, Radix Aconiti Lateralis Preparata 200 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 200 grams are made powder, oral administration dosage: each 16 grams, every day three times.
Claims (9)
1, a kind of medicine for the treatment of asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease is characterized in that:
A, this medicine are made up of bamboo aphid basically, and limited component that other are not pointed out and content thereof are to the not influence in fact of basic medicinal characteristic of pointed bamboo aphid component;
B, oral administration dosage: make tincture, each 30 milliliters, every day three times; Make powder, each 0.3-5 grams, every day three times; Make proportion and be 1.15 oral liquid, each 5-10 milliliters, every day three times.
2, a kind of medicine for the treatment of asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease is characterized in that:
A, this medicine are principal agent with the bamboo aphid, are aided with Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) and make compound preparation;
The ratio of b, bamboo aphid shared weight in this prescription is 40%-60%, and the ratio of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) shared weight in this prescription is 40%-60%;
C, oral administration dosage: make powder, each 0.8-8 gram, every day three times; Make proportion and be 1.15 oral liquid, each 2-20 milliliter, every day three times.
3, a kind of medicine for the treatment of asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease is characterized in that:
A, this medicine are principal agent with the bamboo aphid, are aided with Herba Ephedrae, Ramulus Cinnamomi, Semen Armeniacae Amarum, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Fructus Perillae, Pericarpium Citri Reticulatae, Radix Asteris, Radix Glycyrrhizae and make compound preparation;
The ratio of b, bamboo aphid shared weight in this prescription is 5%-30%, Herba Ephedrae, Ramulus Cinnamomi, Semen Armeniacae Amarum, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Fructus Perillae, Pericarpium Citri Reticulatae, Radix Asteris, Radix Glycyrrhizae were in 1: 1: 1: 1: 1: 1: 1: 0.5 ratio is formed, and the ratio of shared weight is 70%-95% in this prescription;
C, oral administration dosage: make powder, each 6-16 gram, every day three times; Make proportion and be 1.15 oral liquid, each 10-30 milliliter, every day three times.
4, a kind of medicine for the treatment of asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease is characterized in that:
A, this medicine are principal agent with the bamboo aphid, are aided with Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, the Rhizoma Anemarrhenae, Sang Baipi, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Glycyrrhizae and make compound preparation;
The ratio of b, bamboo aphid shared weight in this prescription is 5%-30%, and Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, the Rhizoma Anemarrhenae, Sang Baipi, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Glycyrrhizae were in 1: 1: 2: 1: 1: 1: 0.5 ratio is formed, and the ratio of shared weight is 70%-95% in this prescription;
C, oral administration dosage: make powder, each 6-16 gram, every day three times; Make proportion and be 1.15 oral liquid, each 10-30 milliliter, every day three times.
5, a kind of medicine for the treatment of asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease is characterized in that:
A, this medicine are principal agent with the bamboo aphid, are aided with Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) and make compound preparation;
The ratio of b, bamboo aphid shared weight in this prescription is 5%-30%, and Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) were in 1: 1: 1: 1 ratio is formed.The ratio of shared weight is 70%-95% in this prescription;
C, oral administration dosage: make powder, each 6-16 gram, every day three times; Make proportion and be 1.15 oral liquid, each 10-30 milliliter, every day three times.
6, a kind of medicine for the treatment of asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease is characterized in that:
A, this medicine are principal agent with the bamboo aphid, are aided with Gecko, Semen Armeniacae Amarum, Radix Glycyrrhizae, Radix Ginseng, Poria, Bulbus Fritillariae Uninbracteatae, Cortex Mori, the Rhizoma Anemarrhenae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) and make compound preparation;
The ratio of b, bamboo aphid shared weight in this prescription is 5%-30%, Gecko, Semen Armeniacae Amarum, Radix Glycyrrhizae, Radix Ginseng, Poria, Bulbus Fritillariae Uninbracteatae, Cortex Mori, the Rhizoma Anemarrhenae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) were in 3: 3: 3: 1: 1: 1: 1: 1: 1 ratio is formed, and the ratio of shared weight is 70%-95% in this prescription;
C, oral administration dosage are: make powder, each 6-16 gram, is made proportion and is 1.15 oral liquid, each 10-30 milliliter, every day three times at every day three times.
7, a kind of medicine for the treatment of asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease is characterized in that:
A, this medicine are principal agent with the bamboo aphid, are aided with Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Poria, Rhizoma Alismatis, Rhizoma Dioscoreae, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) and make compound preparation;
The ratio of b, bamboo aphid shared weight in this prescription is 5%-30%.Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Poria, Rhizoma Alismatis, Rhizoma Dioscoreae, Cortex Cinnamomi, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Aconiti Lateralis Preparata were in 1: 1: 1: 1: 1: 1: 1: 1: 1 ratio is formed, and the ratio of shared weight is 70%-95% in this prescription;
C, oral administration dosage: make powder, each 6-16 gram, every day three times; Make proportion and be 1.15 oral liquid, each 10-30 milliliter, every day three times.
8, a kind of preparation method for the treatment of asthma, tracheitis, bronchitis, emphysema, pulmonary heart disease medicine is characterized in that:
A, bamboo aphid is added water, squeeze juice, filter,, boil, cooling with rice wine;
The part by weight of b, bamboo aphid, water and rice wine is 12-20%, 62-70%, 12-20%.
9, according to the medicine of claim 1,2,3,4,5,6 or 7 described treatment asthmas, tracheitis, bronchitis, emphysema, pulmonary heart disease, its main component bamboo aphid is the aphid of bamboo for the host, can be: Insecta, Homoptera, Aphidiadae, occupy the pseudo-angle of bamboo Aphis, occupy the pseudo-angle aphid Pseudoregma bambusicold of bamboo; Insecta, Homoptera, Aphidiadae, dance Aphis, bamboo dance aphid Astegopteryx bambusifoliae; Insecta, Homoptera, Aphidiadae, protruding lip speckle Aphis, the protruding lip speckle of bamboo shoot aphid Takecallistaiwanus; Insecta, Homoptera, Aphidiadae, protruding lip speckle Aphis, bamboo is indulged speckle aphid Takecallis arundinariae; Insecta, Homoptera, Aphidiadae, bamboo color Aphis, bamboo color aphid Melanaphis bambusae.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95111263 CN1119107A (en) | 1994-03-11 | 1995-03-07 | Medicine for curing diseases of respiratory system, esp. bronchial asthma and preparing process thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94111670A CN1108106A (en) | 1994-03-11 | 1994-03-11 | Medical prepn. for treating tracheitis and asthma and the prodn. method thereof |
| CN94111670.0 | 1994-03-11 | ||
| CN 95111263 CN1119107A (en) | 1994-03-11 | 1995-03-07 | Medicine for curing diseases of respiratory system, esp. bronchial asthma and preparing process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1119107A true CN1119107A (en) | 1996-03-27 |
Family
ID=25743464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 95111263 Pending CN1119107A (en) | 1994-03-11 | 1995-03-07 | Medicine for curing diseases of respiratory system, esp. bronchial asthma and preparing process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1119107A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614436A (en) * | 2012-03-31 | 2012-08-01 | 李浩成 | Chinese medicinal preparation for treating pulmonary heart disease and preparation method for Chinese medicinal preparation |
| CN103169907A (en) * | 2012-03-31 | 2013-06-26 | 李浩成 | Traditional Chinese medicine tablet preparation for treating lung-heart disease and preparation method thereof |
| CN103169905A (en) * | 2012-03-31 | 2013-06-26 | 李浩成 | Traditional Chinese medicine capsule preparation for treating lung-heart disease and preparation method thereof |
| CN103169906A (en) * | 2012-03-31 | 2013-06-26 | 李浩成 | Traditional Chinese medicine powder preparation for treating lung-heart disease and preparation method thereof |
| CN105327273A (en) * | 2015-11-10 | 2016-02-17 | 张蓓 | Chinese patent medicine for treating lung distension and preparing method thereof |
| CN106344689A (en) * | 2016-10-20 | 2017-01-25 | 任广印 | Medicine for controlling respiratory diseases and complications thereof and preparation method thereof |
| CN108324919A (en) * | 2018-05-17 | 2018-07-27 | 重庆跃龙生物制药有限公司 | Treat the Chinese medicine composition and the preparation method and application thereof of asthma |
| CN110496182A (en) * | 2019-09-11 | 2019-11-26 | 王兆建 | A kind of asthma drug and preparation method thereof based on kidney-replenishing |
| CN113181329A (en) * | 2021-05-21 | 2021-07-30 | 杨昌林 | Lung-clearing medicinal liquor and preparation method thereof |
-
1995
- 1995-03-07 CN CN 95111263 patent/CN1119107A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614436A (en) * | 2012-03-31 | 2012-08-01 | 李浩成 | Chinese medicinal preparation for treating pulmonary heart disease and preparation method for Chinese medicinal preparation |
| CN103169907A (en) * | 2012-03-31 | 2013-06-26 | 李浩成 | Traditional Chinese medicine tablet preparation for treating lung-heart disease and preparation method thereof |
| CN103169905A (en) * | 2012-03-31 | 2013-06-26 | 李浩成 | Traditional Chinese medicine capsule preparation for treating lung-heart disease and preparation method thereof |
| CN103169906A (en) * | 2012-03-31 | 2013-06-26 | 李浩成 | Traditional Chinese medicine powder preparation for treating lung-heart disease and preparation method thereof |
| CN103169905B (en) * | 2012-03-31 | 2014-04-30 | 陈欣 | Traditional Chinese medicine capsule preparation for treating lung-heart disease and preparation method thereof |
| CN103169907B (en) * | 2012-03-31 | 2014-06-18 | 毕玉珍 | Traditional Chinese medicine tablet preparation for treating lung-heart disease and preparation method thereof |
| CN103169906B (en) * | 2012-03-31 | 2014-06-18 | 李风芹 | Traditional Chinese medicine powder preparation for treating lung-heart disease and preparation method thereof |
| CN105327273A (en) * | 2015-11-10 | 2016-02-17 | 张蓓 | Chinese patent medicine for treating lung distension and preparing method thereof |
| CN106344689A (en) * | 2016-10-20 | 2017-01-25 | 任广印 | Medicine for controlling respiratory diseases and complications thereof and preparation method thereof |
| CN108324919A (en) * | 2018-05-17 | 2018-07-27 | 重庆跃龙生物制药有限公司 | Treat the Chinese medicine composition and the preparation method and application thereof of asthma |
| CN110496182A (en) * | 2019-09-11 | 2019-11-26 | 王兆建 | A kind of asthma drug and preparation method thereof based on kidney-replenishing |
| CN113181329A (en) * | 2021-05-21 | 2021-07-30 | 杨昌林 | Lung-clearing medicinal liquor and preparation method thereof |
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