CN110075255A - One kind is neutralized the effect of alcoholic drinks ball and preparation method thereof - Google Patents

One kind is neutralized the effect of alcoholic drinks ball and preparation method thereof Download PDF

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CN110075255A
CN110075255A CN201910446116.0A CN201910446116A CN110075255A CN 110075255 A CN110075255 A CN 110075255A CN 201910446116 A CN201910446116 A CN 201910446116A CN 110075255 A CN110075255 A CN 110075255A
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parts
effect
ball
alcoholic drinks
radix
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徐博文
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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Abstract

It neutralizes the effect of alcoholic drinks ball the invention discloses one kind, the ball of neutralizing the effect of alcoholic drinks is made of traditional Chinese medicinal components and adhesive, and the traditional Chinese medicinal components are formed by following weight ratio: 15-30 parts of flower of kudzuvine, 6-12 parts of radix aucklandiae, 6-15 parts of fructus amomi, 6-12 parts of Rhizoma Atractylodis Macrocephalae, 12-25 parts of Amomum cardamomum, 9-18 parts of dried orange peel, 6-12 parts of Medicated Leaven, 6-12 parts of rhizoma zingiberis, 9-15 parts of radix scutellariae, 6-12 parts of radix bupleuri, 12-25 parts of rhizoma imperatae, 12-30 parts of hoveniae semoveniae semen, 15-30 parts of calcined CONCHA ARCAE, 15-30 parts of calcined CONCHA MERETRICIS SEU CYCLINAE.The present invention enhances the effect of Gu protects taste in conjunction with traditional Chinese medical theory according to modern medicine clinical research; stomach lining is protected, reduces stomach to the uptake of alcohol, promotes liver to the supersession rate of alcohol metabolism product; curative effect is strengthened, preparation process is simple, pure Chinese herbal medicine preparation; it is cheap; curative effect is reliable, Small side effects, highly-safe; meanwhile it ball good mouthfeel obtained of neutralizing the effect of alcoholic drinks, being convenient for carrying.

Description

One kind is neutralized the effect of alcoholic drinks ball and preparation method thereof
Technical field
It neutralizes the effect of alcoholic drinks ball and preparation method thereof the present invention relates to the technical fields such as medicine, health care product, food more particularly to one kind.
Background technique
With social development, the living standard of the people is improved, and also constantly increases to the consumption of wine, and drinks is poly- as family Meeting, commercial affairs entertain in the necessity added to the fun.But after drinking, have uncomfortable more.Excessive drinking and alcoholic are increasing, sternly The health and social stability of people are affected again.In addition, the intake of long term alcohol is also easy to cause to damage to stomach and liver. Compendium of Material Medica speech: it " crosses drink not save, murder in a moment." modern medicine is it has also been found that excessive consumption of alcohol can nervous system to human body, the heart Multiple organ-tissues such as vascular system are impacted and are seriously endangered to generations such as electrolyte, Nutrition and Metabolisms.Therefore, searching has The food or drug of antialcoholism action become the focus of numerous researchers.
Antialcoholic drug belongs to one of product of pharmaceutical.When human body is drunk, alcohol enters blood by gastrointestinal absorption.Human body Antialcoholism function dependent on a variety of enzymes in liver, the content of these enzymes determines individual to the tolerance of alcohol.Because it Take part in the function of decomposing alcohol, be nontoxic acetic acid by alcohol metabolism, finally resolve into water and carbon dioxide.But anyone The tolerance of alcohol is all limited.In certain time, human body can only be metabolized a certain amount of alcohol.Therefore excessive alcohol It resides in blood, in liver, will lead to the serious damage to human body vitals such as liver, renal function.Drinking too much is easy Phenomena such as causing vomiting, is dizzy, having a headache, seriously affects the health of alcohol user.If long-term excessive consumption of alcohol can not only be damaged The function of spleen, stomach especially liver is done harm to, it is serious also to cause cirrhosis and other organ class diseases；At the same time, long-term excessive The conduction of nervous system can also be inhibited by drinking, and lead to life danger.Therefore, many disintoxicating products drank to alleviate in the market More adverse reactions.
Flower of kudzuvine is neutralized the effect of alcoholic drinks soup, tcm prescription name.Come from " secret record of the orchid chamber ".With changing wine clearing damp, the effect of warming middle-JIAO for easing the stomach.It cures mainly Insobriety, the wet impairment of the spleen.Symptoms include dizziness vomiting, chest diaphragm ruffian is bored, and diet is reduced, irritability, difficult urination or diarrhea.It is clinical On be usually used in controlling wine product.Also in the clinic of present medicine to have research more, excavate its effect relieved the effect of alcohol.Some researches show that flower of kudzuvine solutions Hangover soup being capable of the symptom vomitted after drinking of significant reduction of patient.And for the patient of long-term alcohol, by treatment to its TB, DB, The evaluation index of the liver functions such as ALT, ALP, TBA is substantially reduced, and specific prescription is as follows: 15 grams of flower of kudzuvine, 10 grams of radix aucklandiae, and fructus amomi 15 Gram, 10 grams of Poria cocos, 10 grams of umbellate pore furgus, 10 grams of ginseng, 10 grams of Rhizoma Atractylodis Macrocephalae, 15 grams of Amomum cardamomum, 10 grams of green peel, 10 grams of dried orange peel, 10 grams of Divine Comedy, 10 grams of rhizoma zingiberis, 10 grams of rhizoma alismatis.
Currently, there are many kinds of products of sobering up in the market, the ingredient of each product is different, and effect is also different.Main ingredient Generally pueraria lobata, flower of kudzuvine, green tea, mulberry leaf and honeysuckle etc. are had using extracted form natural plant and are inhibited alcohol absorption acceleration of alcohol row Double effects are let out, precipitating of the remaining alcohol in liver stomach is eliminated, achievees the effect that Soboring-up liver-protecting stomach invigorating, health.But at present Disintoxicating product effect is not significant in the market, and mostly focuses on the effect of relieving the effect of alcohol, and have ignored alcohol to the liver of people and The injury of taste, therefore, producing a kind of efficient and safe product of sobering up has the very big market demand.There are also many solutions in the market Yeast for brewing rice wine is that the product obtained by chemical means remains to be discussed in terms of the safety used.Although and traditional Chinese medicine prescription It works well, but mouthfeel is not good enough, it is public not high to its acceptance level.
Therefore, those skilled in the art is dedicated to developing one kind and neutralizes the effect of alcoholic drinks ball, have preparation process it is simple, it is cheap, Curative effect is reliable, Small side effects, highly-safe, is convenient for carrying, and good mouthfeel, is easier to the advantages such as public receiving.
Summary of the invention
In view of the above drawbacks of the prior art, the technical problem to be solved by the present invention is to how a kind of curative effect is provided can It leans on, Small side effects, highly-safe, good mouthfeel, the ball and preparation method thereof of neutralizing the effect of alcoholic drinks being convenient for carrying, and the preparation method is easy Efficiently, low in cost, green safe.
To achieve the above object, it neutralizes the effect of alcoholic drinks ball the present invention provides one kind, including the bulk pharmaceutical chemicals preparation by following weight proportion Made of preparation: 15-30 parts of flower of kudzuvine, 6-12 parts of radix aucklandiae, 6-15 parts of fructus amomi, 6-12 parts of Rhizoma Atractylodis Macrocephalae, 12-25 parts of Amomum cardamomum, dried orange peel 9- 18 parts, 6-12 parts of Medicated Leaven, 6-12 parts of rhizoma zingiberis, 9-15 parts of radix scutellariae, 6-12 parts of radix bupleuri, 12-25 parts of rhizoma imperatae, hoveniae semoveniae semen 12-30 Part, 15-30 parts of calcined CONCHA ARCAE, 15-30 parts of calcined CONCHA MERETRICIS SEU CYCLINAE.
Further, radix bupleuri and radix scutellariae are added according to the weight ratio of 1:0.75~2.5.Preferably, radix bupleuri and radix scutellariae are pressed According to the weight ratio addition of 1:1 or 1:2.
It further, further include adhesive, adhesive selects refined honey.
Further, preparation also may be selected by pueraria lobata, radix aucklandiae, fructus amomi, Rhizoma Atractylodis Macrocephalae, Amomum cardamomum, dried orange peel, endothelium corneum gigeriae galli, rhizoma zingiberis, pool Rush down, green peel, rhizoma imperatae, hoveniae semoveniae semen, fritillaria thunbergii, calcined oyster shell composition, wherein pueraria lobata replace flower of kudzuvine the effect of, endothelium corneum gigeriae galli replace six mind The effect of the effect of bent effect, rhizoma alismatis, green peel replace radix scutellariae, radix bupleuri, fritillaria thunbergii, calcined oyster shell replace calcined CONCHA ARCAE, calcined CONCHA MERETRICIS SEU CYCLINAE.
Further, preparation is formed by following weight ratio: 20-30 parts of pueraria lobata, 6-12 parts of radix aucklandiae, and 6-15 parts of fructus amomi, 6-12 parts of Rhizoma Atractylodis Macrocephalae, 12-25 parts of Amomum cardamomum, 9-18 parts of dried orange peel, 12-20 parts of endothelium corneum gigeriae galli, 6-12 parts of rhizoma zingiberis, 6-12 parts of rhizoma alismatis, green peel 6-12 parts, 12-25 parts of rhizoma imperatae, 12-30 parts of hoveniae semoveniae semen, 15-30 parts of fritillaria thunbergii, 15-30 parts of calcined oyster shell.
Further, ginseng, Radix Salviae Miltiorrhizae reinforcement curative effect can also be added in preparation, ginseng, Radix Salviae Miltiorrhizae are according to 10-15 parts of parts by weight Ratio addition.
The present invention also provides a kind of method for preparing the ball of neutralizing the effect of alcoholic drinks such as claim 1~7 any one, feature exists In, comprising the following steps:
One, it by the property of Chinese medicine, takes the medicinal material for being not easy to beat powder to decoct effective component extracting and is condensed into condensed cream, remaining medicine Material passes through smashing and grinding into fine powder；
Two, it after mixing by condensed cream obtained in step 1 and fine powder, adds adhesive and ball block is made；
Three, by the mechanical extrusion of ball block obtained in step 2, wet grain drying, sieving, glazing, coating are made pill Condensed pill.
Further, step 2 can also take following manner to carry out: condensed cream obtained in step 1 being made adhesive, is added Enter fine powder, or add refined honey, ball block is made after mixing.
The present invention also provides a kind of a kind of application methods of above-mentioned ball of neutralizing the effect of alcoholic drinks, and the application method is, before drinking It is administered orally.
The present invention is directed to the effect core of antialcoholic drugs, and takes into account Gu shield taste liver to design matching for the traditional Chinese medicinal components Side.
The effect core of antialcoholic drugs is exactly to reduce the concentration of ethyl alcohol and its metabolite in patient's blood, mitigates it to each device The damage of official.According to the metabolic characteristic of ethyl alcohol in vivo, current drug mainly plays antialcoholism action in terms of two.First, suppression The gastrointestinal absorption of preparing alcohol reinforces ethyl alcohol in the first pass effect of gastrointestinal tract, reduces the concentration of alcohol in blood；Second, drug is direct Hepatic metabolism enzyme system is acted on, the supersession rate of accelerating alcohol and its metabolite mitigates its damage to tissue and cell.
Alcohol enter after human body 95% or more be in liver metabolism, hepatocellular injury be also main damage caused by alcohol it One.The present invention designs the radix bupleuri, the ratio of radix scutellariae 1:1 or 1:2 have clear improvement work to the raising of serum alt and AST With prompt plays the role of stable liver plasma membrane, promotes the synthesis of liver internal protein, protection liver cell.And the hepatic injury of ethylism Mechanism first is that activation oxygen molecule, which generates oxygen radical, leads to the lipid peroxidation content of liver plasma membrane, the height of MDA can reflect The intensity of oxygen free radicals and lipid peroxidation.The drug of radix bupleuri radix scutellariae 1:2 ratio can be substantially reduced in liver MDA level from And mitigate hepatocellular injury.
Hoveniae semoveniae semen in the formula can accelerate the metabolism of ethyl alcohol, improve the vigor of glutathione peroxidase in blood, The effects of ALT, AST, MDA caused by ethyl alcohol are increased is reduced, and hepatic steatosis caused by alcohol and inflammation can be mitigated Cellular infiltration reduces fibroplasia.
Because being a disciple of school to focus on caring for shield taste, the present invention is specifically added the blood clam and concha meretricis seu cylinae, this two herbal medicine Taste is salty, mild-natured.There are relieving haperacidity, removing phlegm and blood stasis, resolving hard lump, is chiefly used in hyperhydrochloria, it is noisy, stomach lining can be enhanced Defense function, stomach lining part blood supply and gastric acid secretion are adjusted, to play the role of protecting stomach lining.In the present invention Effect is also that system closes gastric acid, mitigates reaction of having a stomach upset, and reduces absorption of the gastric mucosa to alcohol.Meanwhile the cogongrass used Root takes it to have cooling blood and hemostasis, the function of reducing fever and causing diuresis.Compendium of Material Medica says it, and " the main all blood of hematemesis, typhoid fever hiccup, lung heat asthma is anxious, water It is swollen, jaundice, relieving alcoholism ".Reach reducing fever and causing diuresis using it in the present invention, promotes excretion, the effect of benefit hydrolysis wine.
In addition, causing the clinical research also significant of hepar damnification for long-term alcohol, alcoholic liver disease is clinically Common disease of digestive system.Chinese medicine thinks that alcoholic liver disease is to cause suffocating of liver and gall to be neglected one's duty because of the damp and hot impairing the spleen and stomach of wine poison, Qi and blood dysfunction of the spleen in transportation and transformation, caused by phlegm wet silt accumulates in the costal region.Treat this disease when should using dismiss wine poison, regulating qi-flowing for eliminating phlegm, activating microcirculation and removing stasis medicinal, The principle of invigorating spleen and soothing liver.In addition, also some researches show that remove in addition to radix bupleuri, radix scutellariae, such as ginseng, flower of kudzuvine, hoveniae semoveniae semen natural drug Outside antialcoholism action, apparent internal effect of scavenging radical is all had.Chronic alcoholic liver disease and other it is various forms of in In Toxic liver disease, noxious material has important pathogenic effects in the free radical that intrahepatic metabolism generates.
Heretofore described flower of kudzuvine, hoveniae semoveniae semen can eliminate the active oxygen in patient's liver, and there is stomach function regulating to relieve the effect of alcohol, promote the production of body fluid to quench thirst The effect of, the Amomum cardamomum, fructus amomi, radix aucklandiae, Divine Comedy, radix scutellariae, radix bupleuri have strengthening the spleen and stomach, the function that qi-regulating is soothing the liver, eliminating dampness and eliminating phlegm Effect.The dried orange peel, Rhizoma Atractylodis Macrocephalae, rhizoma imperatae regulating qi-flowing for eliminating phlegm, invigorating the spleen excreting dampness, soothing liver-qi stagnation, the calcined CONCHA ARCAE and calcined CONCHA MERETRICIS SEU CYCLINAE care for shield spleen Stomach, relieving haperacidity preventing or arresting vomiting.Said medicine is shared in the present invention, has effects that dismiss wine poison, regulating qi-flowing for eliminating phlegm, invigorating spleen and soothing liver.
The present invention provides the formulas of traditional Chinese medicinal components described in one group: pueraria lobata, radix aucklandiae, fructus amomi, Rhizoma Atractylodis Macrocephalae, Amomum cardamomum, dried orange peel, chicken Interior gold, rhizoma zingiberis, rhizoma alismatis, green peel, rhizoma imperatae, hoveniae semoveniae semen, fritillaria thunbergii, calcined oyster shell.
Wherein the pueraria lobata and the flower of kudzuvine are homophyletic plant, take different parts to be used as medicine, Thousand Golden Prescriptions are smash with fresh pueraria lobata Juice controls who drunkenly；Amplification on Canon of Materia Medica controls drunken person with kudzu-vine root powder, says: " sick wine and thirsty person, row are good ".Clinical research is more There is proof.Chinese medicament kudzu-vine root has preferable curative effect for treatment Alcoholic poisoning, and the palpitaition that can be effectively improved patient is out of strength, dizzy The symptoms such as headache, nausea and vomiting.And positive effect is suffered from ethyl alcohol absorption, metabolism and the protection of central nervous system.
The endothelium corneum gigeriae galli has it that can control the record of gastric disorder causing nausea, the wine that disappears product in Compendium of Material Medica.Research has shown that inhibit gastrointestinal tract pair The absorption of ethyl alcohol can generate certain effect, for substituting Medicated Leaven, play the role of digestion gathered food, protect stomach.
The rhizoma alismatis inducing diuresis with bland drug, cold in nature to expel the heat-evil, the soothing the liver relieving stagnant Qi of green peel, disperse accumulationization is stagnant, to substitute the radix scutellariae With radix bupleuri, it is clear in coke heat, the gas of scattered liver and gallbladder draws all medicines and enters liver and gallbladder.
The fritillaria thunbergii, calcined oyster shell and the blood clam, clam shell for alcohol to the damage of gastric mucosa in terms of, show Relieving haperacidity shield stomach effect it is close, can be replaced.
In addition ginseng has potential curative effect for treatment Alcoholic poisoning, and the metabolic process of energy acceleration of alcohol alleviates place Liquor-saturated symptom.And Salvia root P.E can reduce the voluntary ethyl alcohol intake of alcohol dependence object, and postpone to generate after drinking Heavily drunk.After Radix Salviae Miltiorrhizae is intervened, the alcohol levels in blood samples content of alcohol user is decreased obviously.Therefore the present invention proposes described in addition Ginseng, Radix Salviae Miltiorrhizae reinforcing effect.
According to modern medicine clinical research, in conjunction with traditional Chinese medical theory, the present invention changes classic prescriptions flower of kudzuvine soup of neutralizing the effect of alcoholic drinks Good, the flavour of a drug for increasing Gu shield taste reduce stomach to the uptake of alcohol, also reduce and drink to protect gastric mucosa The sense of discomfort of person's gastral cavilty, hence it is evident that mitigate the symptoms such as gasteremphraxis, gastric acid and vomiting.On the other hand, increasing numerous clinical tests proves Liver can be promoted to the Chinese medicine of the supersession rate of ethyl alcohol and its metabolite.Dialectical treatmert strengthens curative effect.
In terms of pharmaceutical dosage form, the present invention is taken orally in the form of condensed pill.Compare the shape of conventional medicament decoction Formula improves the mouthfeel of drug, while also more portable, conveniently takes.
The technical effect of design of the invention, specific structure and generation will be described further below, with fully Solve the purpose of the present invention, feature and effect.
Specific embodiment
Multiple preferred embodiments of the invention introduced below keep its technology contents more clear and are easy to understand.The present invention It can be emerged from by many various forms of embodiments, protection scope of the present invention is not limited only to the reality mentioned in text Apply example.
Embodiment 1
One kind is neutralized the effect of alcoholic drinks ball, by the medicinal material of following parts by weight: 15 parts of flower of kudzuvine, 8 parts of radix aucklandiae, and 7 parts of fructus amomi, 11 parts of Rhizoma Atractylodis Macrocephalae, white peas or beans It cool 15 parts, 9 parts of dried orange peel, 12 parts of Medicated Leaven, 7 parts of rhizoma zingiberis, 9 parts of radix scutellariae, 12 parts of radix bupleuri, 20 parts of rhizoma imperatae, 15 parts of hoveniae semoveniae semen, forges watt Stupefied sub 18 parts, 19 parts of calcined CONCHA MERETRICIS SEU CYCLINAE and appropriate refined honey, wherein the radix bupleuri, radix scutellariae weight ratio are 1:0.75, according to the following steps It is made.
Step 1: calcined CONCHA ARCAE and calcined CONCHA MERETRICIS SEU CYCLINAE, which are decocted effective component extracting, is made condensed cream, remaining drug passes through powder Fine powder is made in breakdown mill；
Step 2: the condensed cream obtained in the step 1 and the fine powder are uniformly mixed, add appropriate Soft or hard suitable ball block is made in refined honey；
Step 3: by the mechanical extrusion of the ball block obtained in the step 3, pill, wet grain is dry, sieving, on Light, coating, are made condensed pill.
Embodiment 2
One kind is neutralized the effect of alcoholic drinks ball, by the medicinal material of following parts by weight: 20 parts of flower of kudzuvine, 10 parts of radix aucklandiae, 10 parts of fructus amomi, 10 parts of Rhizoma Atractylodis Macrocephalae, white 20 parts of cardamom, 10 parts of dried orange peel, 10 parts of Medicated Leaven, 7 parts of rhizoma zingiberis, 10 parts of radix scutellariae, 10 parts of radix bupleuri, 20 parts of rhizoma imperatae, 20 parts of hoveniae semoveniae semen, 20 parts of calcined CONCHA ARCAE, 20 parts of calcined CONCHA MERETRICIS SEU CYCLINAE and appropriate refined honey, wherein the radix bupleuri, radix scutellariae weight ratio are 1:1, according to following step Suddenly it is made.
Step 1: calcined CONCHA ARCAE and calcined CONCHA MERETRICIS SEU CYCLINAE, which are decocted effective component extracting, is made condensed cream, remaining drug passes through powder Fine powder is made in breakdown mill；
Step 2: the condensed cream obtained in the step 1 and the fine powder are uniformly mixed, add appropriate Soft or hard suitable ball block is made in refined honey；
Step 3: by the mechanical extrusion of the ball block obtained in the step 3, pill, wet grain is dry, sieving, on Light, coating, are made condensed pill.
Embodiment 3
One kind is neutralized the effect of alcoholic drinks ball, by the medicinal material of following parts by weight: 25 parts of flower of kudzuvine, 12 parts of radix aucklandiae, 14 parts of fructus amomi, 11 parts of Rhizoma Atractylodis Macrocephalae, white 25 parts of cardamom, 15 parts of dried orange peel, 12 parts of Medicated Leaven, 12 parts of rhizoma zingiberis, 12 parts of radix scutellariae, 6 parts of radix bupleuri, 25 parts of rhizoma imperatae, 25 parts of hoveniae semoveniae semen, 30 parts of calcined CONCHA ARCAE, 30 parts of calcined CONCHA MERETRICIS SEU CYCLINAE and appropriate refined honey, wherein the radix bupleuri, radix scutellariae weight ratio are 1:2, according to following step Suddenly it is made.
Step 1: calcined CONCHA ARCAE and calcined CONCHA MERETRICIS SEU CYCLINAE, which are decocted effective component extracting, is made condensed cream, remaining drug passes through powder Fine powder is made in breakdown mill；
Step 2: the condensed cream obtained in the step 1 and the fine powder are uniformly mixed, add appropriate Soft or hard suitable ball block is made in refined honey；
Step 3: by the mechanical extrusion of the ball block obtained in the step 3, pill, wet grain is dry, sieving, on Light, coating, are made condensed pill.
Embodiment 4
One kind is neutralized the effect of alcoholic drinks ball, by the medicinal material of following parts by weight: 30 parts of flower of kudzuvine, 12 parts of radix aucklandiae, 15 parts of fructus amomi, 12 parts of Rhizoma Atractylodis Macrocephalae, white 25 parts of cardamom, 18 parts of dried orange peel, 12 parts of Medicated Leaven, 12 parts of rhizoma zingiberis, 15 parts of radix scutellariae, 6 parts of radix bupleuri, 25 parts of rhizoma imperatae, 30 parts of hoveniae semoveniae semen, 30 parts of calcined CONCHA ARCAE, 30 parts of calcined CONCHA MERETRICIS SEU CYCLINAE and appropriate refined honey, wherein the radix bupleuri, radix scutellariae weight ratio are 1:2.5, according to following Step is made.
Step 1: calcined CONCHA ARCAE and calcined CONCHA MERETRICIS SEU CYCLINAE, which are decocted effective component extracting, is made condensed cream, remaining drug passes through powder Fine powder is made in breakdown mill；
Step 2: the condensed cream obtained in the step 1 and the fine powder are uniformly mixed, add appropriate Soft or hard suitable ball block is made in refined honey；
Step 3: by the mechanical extrusion of the ball block obtained in the step 3, pill, wet grain is dry, sieving, on Light, coating, are made condensed pill.
Embodiment 5
One kind is neutralized the effect of alcoholic drinks ball, by the medicinal material of following parts by weight: 24 parts of pueraria lobata, 8 parts of radix aucklandiae, and 12 parts of fructus amomi, 11 parts of Rhizoma Atractylodis Macrocephalae, white peas or beans Cool 22 parts, 10 parts of dried orange peel, 13 parts of endothelium corneum gigeriae galli, 11 parts of rhizoma zingiberis, 9 parts of rhizoma alismatis, 9 parts of green peel, 15 parts of rhizoma imperatae, 16 parts of hoveniae semoveniae semen, Zhejiang 25 parts of fritillaria, 25 parts of calcined oyster shell and appropriate refined honey are made according to the following steps.
Step 1: fritillaria thunbergii and calcined oyster shell, which are decocted effective component extracting, is made condensed cream, remaining drug passes through crushing Fine powder is made in grinding；
Step 2: the condensed cream obtained in the step 1 and the fine powder are uniformly mixed, add appropriate Soft or hard suitable ball block is made in refined honey；
Step 3: by the mechanical extrusion of the ball block obtained in the step 3, pill, wet grain is dry, sieving, on Light, coating, are made condensed pill.
Embodiment 6
One kind is neutralized the effect of alcoholic drinks ball, by the medicinal material of following parts by weight: 30 parts of pueraria lobata, 11 parts of radix aucklandiae, and 8 parts of fructus amomi, 6 parts of Rhizoma Atractylodis Macrocephalae, white peas or beans Cool 25 parts, 15 parts of dried orange peel, 20 parts of endothelium corneum gigeriae galli, 8 parts of rhizoma zingiberis, 12 parts of rhizoma alismatis, 6 parts of green peel, 20 parts of rhizoma imperatae, 25 parts of hoveniae semoveniae semen, Zhejiang 30 parts of fritillaria, 15 parts of calcined oyster shell, 15 parts of ginseng, 15 parts of Radix Salviae Miltiorrhizae and appropriate refined honey are made according to the following steps.
Step 1: calcined CONCHA ARCAE and calcined CONCHA MERETRICIS SEU CYCLINAE, which are decocted effective component extracting, is made condensed cream, remaining drug passes through powder Fine powder is made in breakdown mill；
Step 2: the condensed cream obtained in the step 1 and the fine powder are uniformly mixed, add appropriate Soft or hard suitable ball block is made in refined honey；
Step 3: by the mechanical extrusion of the ball block obtained in the step 3, pill, wet grain is dry, sieving, on Light, coating, are made condensed pill.
Dispelling effects of alcohol experiment
One, pharmacological experiment study:
Experimental material: ball of neutralizing the effect of alcoholic drinks prepared by above-described embodiment 1~6, grinding is soluble in water, dense according to the administration of 0.5g/kg Degree is configured to solution；And the drunkenness dispelling kudzuvine flower soup prepared according to conventional formulation is as reference group；Ethyl alcohol is that 53 ° of Luzhou Old Cellars two are bent Wine.
Experimental group: kunming mice 90,20 ± 2g of weight.Fasting 12h, free water.Be randomly divided into blank, model, 6 experimental groups of reference, Examples 1 to 6,9 groups in total, every group 10.
Experimental method: only, the daily stomach-filling of remaining each group is to wine 0.4mL/ by the daily stomach-filling water supply 0.4mL/ of blank group.Model For group daily to 30min stomach-filling before wine to 0.4mL/, physiological saline, each administration group gives 30min gastric infusion 0.4mL/ before wine daily Only, 30min stomach-filling water supply 0.4mL/ before the daily water supply of blank group.It is carried out continuously 10, and respectively on the 8th, 9,10 pair Mouse carries out Righing reflex, and observation the number of elements of righting reflex loss, righting reflex loss occurs to mouse in 0.5h after drinking It is believed that animal is drunk, adds up 5 observed results, count drunk rate, statistical result is shown in Table 1.The 10th day to wine for 24 hours after, survey Determine aspartate aminotransferase in serum (AST), alanine aminotransferase (ALT) activity, and puts to death mouse rapidly, takes out Hepatic tissue, is made 10% homogenate by liver weighing, measures MDA value in liver, and measurement result is shown in Table 2.
The drunk rate experimental result of 1 mouse of table
The result shows that each administration group is compared with model group, reference group, drunk rate is substantially reduced table 1, illustrates solution of the invention Hangover ball has the function of good pre- preventing drunkenness.Wherein embodiment 2,3 corresponding radix bupleuri, radix scutellariae weight ratio be 1:1 and 1:2 and The effect of the ball of neutralizing the effect of alcoholic drinks of these three formula preparations of addition ginseng, Radix Salviae Miltiorrhizae is especially significant in embodiment 6.
The comparison result of MDA in 2 mice serum ALT, AST activity of table and liver
Table 2 statistics indicate that each administration group is significantly reduced effect to serum alt, the active tool that increases of AST, wherein with The effect of the ball of neutralizing the effect of alcoholic drinks for the formula preparation that radix bupleuri, radix scutellariae weight ratio are 1:2 in embodiment 3,6 is most preferably, followed by embodiment 2 The ball of neutralizing the effect of alcoholic drinks for the formula preparation that radix bupleuri, radix scutellariae weight ratio are 1:1.And the effect of ball prepared by the present invention of neutralizing the effect of alcoholic drinks is also significantly better than biography The drunkenness dispelling kudzuvine flower soup of side's preparation under unified central planning.
Two, clinical dispelling effects of alcohol experiment:
Experimental material: ball of neutralizing the effect of alcoholic drinks prepared by above-described embodiment 1~6, and the drunkenness dispelling kudzuvine flower soup prepared according to conventional formulation As reference group；Ethyl alcohol is 53 ° of two bent wines of Luzhou Old Cellar.
Experimental group: totally 48 volunteers, men and women is fifty-fifty, without frequent drinking behavior, average age 26 years old, weight 50 ± 10kg, fasting 6h.It is randomly divided into 6 experimental groups of blank, reference, Examples 1 to 6,8 groups in total, every group of 6 people.
Experimental method: it is oral that blank control group gives 53 ° of Luzhou Old Cellars, two bent wine 100mL；Everyone empty stomach oral administration of reference group Take that 53 ° of Luzhou Old Cellars, two bent wine 100mL is given after drunkenness dispelling kudzuvine flower soup 30min is oral；6 experimental group everyone empty stomach oral administrations are taken It is oral that 53 ° of Luzhou Old Cellars, two bent wine 100mL is given after the corresponding ball 30min prepared in the above embodiments that neutralizes the effect of alcoholic drinks.Respectively at 30min Aspartic acid transamination in laggard pedestrian's body balance test, human exhaled breath's ethanol content, blood of human body ethanol content and serum Enzyme (AST), alanine aminotransferase (ALT) measurement.And count mouthfeel feedback.
Measuring the results are shown in Table 3.
Table 3 is neutralized the effect of alcoholic drinks ball dispelling effects of alcohol measuring result
The experimental result tested by total balance of the body finds 30min after oral alcohol, takes solution prepared in the above embodiments The balanced ability of human body of the observation group objects of hangover ball is substantially better than blank control group.And it can be seen that observation group by data in table 3 Human exhaled breath's ethanol content, blood of human body ethanol content and aspartate aminotransferase (AST), alanine aminotransferase (ALT) measurement numerical value is below blank control group, shows outstanding dispelling effects of alcohol.
Further, the weight ratio for adjusting radix bupleuri radix scutellariae, radix bupleuri in Examples 1 to 4, radix scutellariae weight part ratio be respectively 1: 0.75,1:1,1:2,1:2.5.In measurement result, expiration, the blood of the experimental subjects of ball prepared with embodiment 3 of neutralizing the effect of alcoholic drinks are taken In ethanol content be substantially less than the experimental subjects of blank group, reference group and other administration groups, and the reduction to AST and ALT Also excellent effect is shown.This is because when the weight part ratio of radix bupleuri, Radix Astragali is 1:2, for stablizing liver plasma membrane, promoting The synthesis of liver internal protein, protection liver cell have better effect, it is suppressed that actually for the damage of liver.Simultaneously with its other medicine Object combines, realize more efficiently reduce taste to the absorption of alcohol, promote liver to the supersession rate of alcohol and its metabolite, The protection to taste liver is enhanced while improving dispelling effects of alcohol.
And embodiment 5 takes the Chinese medicinal composition ingredient different from Examples 1 to 4, ball obtained of neutralizing the effect of alcoholic drinks equally is shown Outstanding dispelling effects of alcohol.
Further, embodiment 6 is added to ginseng and Components in Salvia miltiorrhiza, obtained ball of neutralizing the effect of alcoholic drinks on the basis of embodiment 3 Dispelling effects of alcohol be further improved.This is because ginseng has potential curative effect, energy for treatment Alcoholic poisoning The metabolic process of acceleration of alcohol alleviates symptom of being still drank after a night；And Salvia root P.E can reduce voluntary ethyl alcohol intake, and postpone to drink The Heavily drunk generated later.After Radix Salviae Miltiorrhizae is intervened, alcohol levels in blood samples content is decreased obviously, and enhances dispelling effects of alcohol.
And it is added with refined honey in ball prepared by the present invention of neutralizing the effect of alcoholic drinks, improves the mouthfeel of Chinese medicinal pill well.
The preferred embodiment of the present invention has been described in detail above.It should be appreciated that the ordinary skill of this field is without wound The property made labour, which according to the present invention can conceive, makes many modifications and variations.Therefore, all technician in the art Pass through the available technology of logical analysis, reasoning, or a limited experiment on the basis of existing technology under this invention's idea Scheme, all should be within the scope of protection determined by the claims.

Claims (9)

  1. The ball 1. one kind is neutralized the effect of alcoholic drinks, which is characterized in that including the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion: flower of kudzuvine 15- 30 parts, 6-12 parts of radix aucklandiae, 6-15 parts of fructus amomi, 6-12 parts of Rhizoma Atractylodis Macrocephalae, 12-25 parts of Amomum cardamomum, 9-18 parts of dried orange peel, 6-12 parts of Medicated Leaven, 6-12 parts of rhizoma zingiberis, 9-15 parts of radix scutellariae, 6-12 parts of radix bupleuri, 12-25 parts of rhizoma imperatae, 12-30 parts of hoveniae semoveniae semen, 15-30 parts of calcined CONCHA ARCAE, 15-30 parts of calcined CONCHA MERETRICIS SEU CYCLINAE.
  2. The ball 2. one kind as described in claim 1 is neutralized the effect of alcoholic drinks, which is characterized in that the radix bupleuri and radix scutellariae are according to 1:0.75~2.5 Weight ratio addition.
  3. The ball 3. one kind as claimed in claim 2 is neutralized the effect of alcoholic drinks, which is characterized in that the radix bupleuri and radix scutellariae according to 1:1~2 weight ratio Example addition.
  4. The ball 4. one kind as described in claim 1 is neutralized the effect of alcoholic drinks, which is characterized in that further include adhesive, described adhesive selects refined honey.
  5. The ball 5. one kind as described in claim 1 is neutralized the effect of alcoholic drinks, which is characterized in that the preparation also may be selected by pueraria lobata, radix aucklandiae, sand Benevolence, Rhizoma Atractylodis Macrocephalae, Amomum cardamomum, dried orange peel, endothelium corneum gigeriae galli, rhizoma zingiberis, rhizoma alismatis, green peel, rhizoma imperatae, hoveniae semoveniae semen, fritillaria thunbergii, calcined oyster shell composition, Described in pueraria lobata replace the flower of kudzuvine the effect of, the endothelium corneum gigeriae galli replace the Medicated Leaven the effect of, the rhizoma alismatis, green peel replace The effect of the effect of radix scutellariae, radix bupleuri, the fritillaria thunbergii, calcined oyster shell replace the calcined CONCHA ARCAE, calcined CONCHA MERETRICIS SEU CYCLINAE.
  6. The ball 6. one kind as claimed in claim 5 is neutralized the effect of alcoholic drinks, which is characterized in that the preparation is formed by following weight ratio: Pueraria lobota 20-30 parts of root, 6-12 parts of radix aucklandiae, 6-15 parts of fructus amomi, 6-12 parts of Rhizoma Atractylodis Macrocephalae, 12-25 parts of Amomum cardamomum, 9-18 parts of dried orange peel, endothelium corneum gigeriae galli 12- 20 parts, 6-12 parts of rhizoma zingiberis, 6-12 parts of rhizoma alismatis, 6-12 parts of green peel, 12-25 parts of rhizoma imperatae, 12-30 parts of hoveniae semoveniae semen, fritillaria thunbergii 15-30 Part, 15-30 parts of calcined oyster shell.
  7. The ball 7. one kind as claimed in claim 5 is neutralized the effect of alcoholic drinks, which is characterized in that ginseng can also be added in the preparation, Radix Salviae Miltiorrhizae is reinforced Curative effect, the ginseng, Radix Salviae Miltiorrhizae are added according to 10-15 parts of weight ratios.
  8. 8. a kind of method for preparing the ball of neutralizing the effect of alcoholic drinks as described in claim 1~7 any one, which is characterized in that including following step It is rapid:
    One, it by the property of Chinese medicine, takes the medicinal material for being not easy to beat powder to decoct effective component extracting and is condensed into condensed cream, remaining medicinal material is equal By smashing and grinding into fine powder；
    Two, it after mixing by condensed cream obtained in step 1 and fine powder, adds described adhesive and ball block is made；
    Three, by the mechanical extrusion of ball block obtained in step 2, concentration is made in wet grain drying, sieving, glazing, coating by pill Ball.
  9. 9. method according to claim 8, which is characterized in that step 2 can also take following manner to carry out: will be in step 1 Condensed cream obtained makees adhesive, fine powder is added, or add refined honey, ball block is made after mixing.
CN201910446116.0A 2019-05-27 2019-05-27 One kind is neutralized the effect of alcoholic drinks ball and preparation method thereof Pending CN110075255A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115737777A (en) * 2022-12-19 2023-03-07 河南中医药大学 Compound anti-alcoholism traditional Chinese medicine composition and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
刘仁慧等: "柴胡黄芩配伍解酒作用研究", 《中药药理与临床》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115737777A (en) * 2022-12-19 2023-03-07 河南中医药大学 Compound anti-alcoholism traditional Chinese medicine composition and preparation method thereof
CN115737777B (en) * 2022-12-19 2023-12-05 河南中医药大学 Compound anti-alcohol traditional Chinese medicine composition and preparation method thereof

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Application publication date: 20190802