CN107412665B - It is a kind of that there is Chinese medicine composition for relieving the effect of alcohol, preventing alcoholic liver injury and its preparation method and application - Google Patents

It is a kind of that there is Chinese medicine composition for relieving the effect of alcohol, preventing alcoholic liver injury and its preparation method and application Download PDF

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CN107412665B
CN107412665B CN201710802723.7A CN201710802723A CN107412665B CN 107412665 B CN107412665 B CN 107412665B CN 201710802723 A CN201710802723 A CN 201710802723A CN 107412665 B CN107412665 B CN 107412665B
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alcohol
effect
medicine composition
chinese medicine
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CN107412665A (en
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张钰
王雪
蔡静
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    • A—HUMAN NECESSITIES
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    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A61K36/068—Cordyceps
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Abstract

The invention discloses a kind of Chinese medicine composition for having and relieving the effect of alcohol, preventing alcoholic liver injury and its preparation method and application.The present invention is made including following bulk pharmaceutical chemicals by weight：10 200 parts of American Ginseng,10 200 parts of hoveniae semoveniae semen,10 200 parts of sun-dried ginseng,10 200 parts of rhodiola root,10 100 parts of Poria cocos,10 60 parts of rhizome of cyrtomium,10 60 parts of dried orange peel,10 60 parts of roud cardamon seed,10 100 parts of psoralea corylifolia,10 100 parts of radix glycyrrhizae,10 200 parts of cynanchum wilfordii,10 200 parts of raw hawthorn,10 200 parts of galangal,10 200 parts of Bupleurum Chinese,10 80 parts of polygala,10 100 parts of the stem of noble dendrobium,Raw 10 200 parts of radix scutellariae,10 200 parts of umbellate pore furgus,10 200 parts of dark plum,10 200 parts of Radix Puerariae,10 200 parts of cordyceps sinensis,10 200 parts of the bletilla striata,10 200 parts of fevervine,10 60 parts of fructus schisandrae,10 100 parts of wilsonii.The present invention has significant Dealcoholic sobering-up, prevention and treatment because of the acute liver damage caused by alcohol the effect of.

Description

A kind of Chinese medicine composition with the alcoholic liver injury that relieves the effect of alcohol, prevents and its preparation side Method and application
Technical field
The present invention relates to a kind of Chinese medicine composition for having and relieving the effect of alcohol, preventing alcoholic liver injury and preparation method thereof and answer With belonging to pharmaceutical technology field.
Background technology
China is a country with deep spirits culture, and wine becomes national and carries out the indispensable work of social activities already Tool.Alcohol is absorbed from intestines and stomach quickly enters blood, 100% can be absorbed in two hours.Liver is the main of metabolism alcohol Organ, the alcohol dehydrogenase (ADH) that alcohol passes through in liver are catalyzed and generate acetaldehyde, and acetaldehyde takes off through the acetaldehyde in liver mitochondrion Hydrogen enzyme (ALDH) is further oxidized to nontoxic acetic acid, ultimately generates carbon dioxide and energy.
However, the speed of liver oxidative metabolism alcohol is very slow, heavy drinking can cause the concentration of alcohol in blood drastically to rise Height, causes acute alcoholism i.e. drunk.After acute alcoholism, the discomfort of long period can be caused, the long period occur Have a headache, is dizzy, have a sleepless night, is weak, trembling, having a stomach upset and is nauseous, or even showing as hyponea.Long-term excessive consumption of alcohol, liver Accumulation of poisoning easily occurs, causes hepatic injury.
At present, product of sobering up on the market is with natural honey main material mostly.However, honey sober up effect itself has Limit, effect is not good enough, and supply falls short of demand for natural honey in addition, expensive, is not suitable for the demand of industrialization.
The content of the invention
It is an object of the present invention to provide a kind of Chinese medicine composition and its system with the alcoholic liver injury that relieves the effect of alcohol, prevents Preparation Method and application.The present invention has significant Dealcoholic sobering-up, prevention and treatment because of the acute liver damage caused by alcohol the effect of. Meanwhile any chemical addition agent is free of in inventive formulation, take securely and reliably, have no toxic side effect.
In order to solve the above technical problems, technical solution provided by the invention is as follows：One kind, which has, relieves the effect of alcohol, prevents alcoholic liver The Chinese medicine composition of damage, is made including following bulk pharmaceutical chemicals by weight：It is 50-90 parts of American Ginseng, 10-50 parts of hoveniae semoveniae semen, sun-dried 4-9 parts of ginseng, 2-5 parts of rhodiola root, 0.2-1 parts of Poria cocos, 10-60 parts of rhizome of cyrtomium, 10-60 parts of dried orange peel, 10-60 parts of roud cardamon seed, psoralea corylifolia 10-100 parts, 10-100 parts of radix glycyrrhizae, 10-200 parts of cynanchum wilfordii, 10-200 parts of raw hawthorn, 10-200 parts of galangal, Bupleurum Chinese 10- 200 parts, 10-80 parts of polygala, 10-100 parts of the stem of noble dendrobium, raw 10-200 parts of radix scutellariae, 10-200 parts of umbellate pore furgus, 10-200 parts of dark plum, elegant jessamine 10-200 parts of root, 10-200 parts of cordyceps sinensis, 10-200 parts of the bletilla striata, 10-200 parts of fevervine, 10-60 parts of Schisandra chinensis, wilsonii 10-100 parts.
The Schisandra chinensis can use fructus schisandrae or kadsura longepedunculata, preferably fructus schisandrae.
Above-mentioned has in the Chinese medicine composition for relieving the effect of alcohol, preventing alcoholic liver injury, by weight including following bulk pharmaceutical chemicals It is made：10-100 parts of American Ginseng, 10-100 parts of hoveniae semoveniae semen, 10-100 parts of sun-dried ginseng, 10-100 parts of rhodiola root, 10-80 parts of Poria cocos, 10-30 parts of rhizome of cyrtomium, 10-50 parts of dried orange peel, 10-30 parts of roud cardamon seed, 10-80 parts of psoralea corylifolia, 10-80 parts of radix glycyrrhizae, cynanchum wilfordii 10-100 Part, 10-100 parts of raw hawthorn, 10-100 parts of galangal, 10-100 parts of Bupleurum Chinese, 10-50 parts of polygala, 10-80 parts of the stem of noble dendrobium, raw Huang 10-100 parts of a kind of reed mentioned in ancient books, 10-100 parts of umbellate pore furgus, 10-100 parts of dark plum, 10-150 parts of Radix Puerariae, 10-100 parts of cordyceps sinensis, bletilla striata 10- 100 parts, 10-100 parts of fevervine, 10-50 parts of Schisandra chinensis, 10-100 parts of wilsonii.
Foregoing has in the Chinese medicine composition for relieving the effect of alcohol, preventing alcoholic liver injury, by weight including following bulk pharmaceutical chemicals It is made：100 parts of American Ginseng, 100 parts of hoveniae semoveniae semen, 100 parts of sun-dried ginseng, 100 parts of rhodiola root, 50 parts of Poria cocos, 30 parts of rhizome of cyrtomium, dried orange peel 50 Part, 30 parts of roud cardamon seed, 50 parts of psoralea corylifolia, 50 parts of radix glycyrrhizae, 80 parts of cynanchum wilfordii, 50 parts of raw hawthorn, 50 parts of galangal, Bupleurum Chinese 50 It is part, 50 parts of polygala, 80 parts of the stem of noble dendrobium, raw 80 parts of radix scutellariae, 80 parts of umbellate pore furgus, 80 parts of dark plum, 100 parts of Radix Puerariae, 30 parts of cordyceps sinensis, white 50 parts of splendid achnatherum, 50 parts of fevervine, 50 parts of fructus schisandrae, 80 parts of wilsonii.
Foregoing has in the Chinese medicine composition for relieving the effect of alcohol, preventing alcoholic liver injury, comprises the following steps：
(1) American Ginseng, sun-dried ginseng, cordyceps sinensis, the bletilla striata, Radix Puerariae, dark plum, radix glycyrrhizae, the stem of noble dendrobium, dried orange peel are crushed, crosses 80 Mesh sieve, it is spare to obtain fine powder；
(2) by hoveniae semoveniae semen, rhodiola root, cynanchum wilfordii, fevervine, raw hawthorn, galangal, Bupleurum Chinese, raw radix scutellariae, umbellate pore furgus, white 8-15 times of cool benevolence, rhizome of cyrtomium, polygala, Schisandra chinensis, wilsonii, Poria cocos, psoralea corylifolia, Radix Puerariae deionized water, extraction 2-3 times, often When secondary 1-3 is small, filtering, filtrate concentration, dry, pulverize, it is spare to obtain water extract；
(3) after mixing fine powder and water extract, then it is mixed together with pharmaceutic adjuvant, oral system is made according to a conventional method Agent.
Foregoing Chinese medicine composition is being prepared with the application in relieving the effect of alcohol, preventing the medicine of alcoholic liver injury.
Foregoing has in the Chinese medicine composition for relieving the effect of alcohol, preventing alcoholic liver injury, and the formulation of the Chinese medicine composition is hard Capsule, soft capsule, tablet, granule, powder, pill, tea bag.
In the Chinese medicine composition of the present invention, the pharmacological action of each bulk pharmaceutical chemicals is as follows：
American Ginseng is the dry root of Araliaceae American Ginseng Panax quinquefolium L..Alias is Westerner Ginseng, western ginseng, American ginseng, American ginseng.There is boosting qi and nourishing yin, clearing heat and promoting fluid.For deficiency of vital energy yin deficiency, interior heat, cough and asthma phlegm blood, abnormal heat It is tired it is tired, quench one's thirst, the disease such as dryness of the mouth and throat.With antifatigue, anti-oxidant, resisting stress, suppress platelet aggregation, reduction blood coagulability Effect, in addition, to diabetic also have adjust blood glucose effect.《Book on Chinese herbal medicine asks former》Recording American Ginseng has clearing lung-heat kidney, cool Heart spleen with fall fire, relieve summer heat, relieve the effect of alcohol the effect of.American Ginseng contains more than ten kind ginsenosides, a small amount of volatile oil, carbohydrate, amino acid, nothing Machine element etc..Modern research shows that American Ginseng has hepatoprotective effect, the following aspects is mainly manifested in：American ginseng stem-leaf total saponin It can make hepatic glycogen content and the rise of glutathione peroxidase activity, third by reducing the activity of alanine aminotransferase in serum Dialdehyde content reduces, so that the hepatic injury caused by mitigating carbon tetrachloride；The active ingredient ginsenoside Ro of American Ginseng is resistant to hepatitis, There is protective effect to hepatic injury；Radix Panacis Quinquefolii polysaccharide has significant protective effect to the hepatic injury caused by D- amino acid galactolipins, Its mechanism of action is to stablize and strengthen liver plasma membrane, protection liver cell mitochondria and the phase for maintaining hepatic tissue cAMP/cGMP ratios To stabilization.Zoopery confirms that American ginseng total saponins and its total extract can reduce the hepatic glycogen content of cavy, increases liver The content of DNA and RNA；American Ginseng can substantially reduce the serum glutaminic acid transaminase rise caused by ethanol, it is possible to increase ethanol institute Serum and liver Glutathione Peroxidase Activity are caused, suppresses the growth of Peroxidation Product malonaldehyde, so as to play protection liver Dirty effect.
Hoveniae semoveniae semen is the fruit or kind with meat carpopodium of Rhamnaceae plant trifoliate orange Dulcis Hovenia dulcis Thunb. Son.Alias honey raisin tree, chicken feet tree, chicken feet pawl, Wan Ziguo, papaw, tangerine turn round son etc..With relieving restlessness of quenching the thirst, clearing away damp-heat, relieving alcoholism Effect.Vomit inverse, difficulty in urination and defecation for middle wine poison, polydipsia.Containing substantial amounts of glucose, organic acid in hoveniae semoveniae semen, people can be expanded The blood volume of body, and energy relieving alcoholism, therefore play the role of sobering up and calm the nerves.《The southern regions of the Yunnan Province book on Chinese herbal medicine》Described in：It is right that hoveniae semoveniae semen controls all left paralysiss Paralysis, rheumatic numbness can relieving alcoholism.Modern pharmacological studies have shown that hoveniae semoveniae semen has the function that accelerating alcohol metabolism；Enhancing ethanol takes off Hydrogenase activity；The report hoveniae semoveniae semen aqueous extract such as Ji Yang can shorten mouse and sober up the time；The flavanone got from hoveniae semoveniae semen Suppress alcohol induced Muscle relaxation；Hoveniae semoveniae semen water extract can significantly inhibit MDA, TG and TC caused by ethanol and LPS and raise；Trifoliate orange Dulcis homogenate liquid energy significantly reduces MDA contents in serum, and is in obvious dose-effect relationship；Hoveniae semoveniae semen homogenate liquid energy dramatically increases mouse SOD contents in liver, brain tissue；The advance gastric infusion of hoveniae semoveniae semen aqueous extract can prevent the mouse liver MDA rises caused by ethanol Decline with GSH, and cholesterol, the triglycerides caused by energy Anti-ethanol increase, and prompt it to alcohol induced mice liver lipids Peroxidating has protective effect, it is possible to which the fatty liver caused by delaying and preventing ethanol is formed；Shi Zhen researchs show that hoveniae semoveniae semen has Anti- Early hepatic fibrosis effect；Ji Yang etc. studies hoveniae semoveniae semen aqueous extract to liver cell without obvious infringement.
Elegant jessamine one, outer literary fame Pueraria lobata (Willd.) Ohwi, head are seen《Sheng Nong's herbal classic》.Wild Pueraria Root includes 12% flavone compound, such as Puerarin, daizeol glycosides, peanut element nutritional ingredient, also has protein, amino The mineral matter such as acid, sugared and iron needed by human, calcium, copper, selenium.Relieve the effect of alcohol on pueraria lobata, it is early on the books in ancient books.《Haigoushen》Claim Pueraria lobata " whetting the appetite, principal solution wine poison, stops polydipsia "；《Bencao Shiyi》Record, kudzu-vine root powder " relieving alcoholism "；《Prescriptions worth thousand gold》There is " pueraria lobata A pipeful of two liters of juice, controlling for drink drunk are not waken up " say.
Cordyceps sinensis Cordyceps sinensis (Berk.) Sacc be Clavicipitaceae plant aweto stroma and The complex of the larva corpse of its host's Hepialidae insect Hepialus etc..Cordyceps sinensis can improve patient's liver function, subtract The inflammatory cell infiltration and degeneration of liver cells necrosis, Chinese caterpillar fungus hypha of light liver have stronger hepatocyte repair；Cordyceps sinensis is more Glycolipid plastid (CPL) has certain protective effect to the CCl4 hepatic tissues damaged；It is thin that the water-soluble liquid energy of cordyceps sinensis suppresses liver depot fat Born of the same parents breed, moreover it is possible to suppress liver Ito Cells and converted to myofibroblasts and fibroblast.
Raw hawthorn (Crataegus pinnatifida Bunge), also known as hawthorn, large-fruited Chinese hawthorn, rose family hawthorn, falls Leaf arbor.Acted on reducing blood lipid, blood pressure, cardiac stimulant, arrhythmia etc., while be also spleen benefiting and stimulating the appetite, relieving dyspepsia, promoting blood circulationization The good medicine of phlegm, the disease such as, hernia, blood stasis full to chest diaphragm spleen, amenorrhoea have the effect of fine.Flavone compound Vitex negundo var cannabifolia in hawthorn Element, is a kind of stronger medicine of antitumaous effect, its extract has one to suppressing internal growth of cancer cells, propagation and infiltration metastasis Fixed effect.Hawthorn and flavone of hawthorn fruit tool antioxidation, can significantly reduce malonaldehyde (MDA) content in serum and liver, increase The activity of strong red blood cell and Liver Superoxide Dismutase Activity (SOD), at the same strengthen plasma glutathione peroxidase (GSH- Px it is) active.
Cynanchum wilfordii, is called radix cynanchi bungei (scientific name：Cynanchum bungei Decne) belong to Gentianales；Also known as RADIX GINSENG ALBA.Respectively Family is discussed《Shandong Chinese medicine》：To nourish, strong, antianaemics, and vital essence can be restrained, crow must dark hair.Control prolonged illness weakness, anaemia, palpus Early white, the chronic wandering arthritis of hair, soreness and weakness of waist and knees, neurasthenia sexualis, hemorrhoid, enterorrhagia, deficiency of Yin chronic malaria, ulcer do not close up long.It is fresh and Relax bowel, suitable for old people constipation.Radix cynanchi bungei general glycoside liver of hemolytic anemia caused by acetophenone has bright Aobvious protective effect, can make the enzymatic activity of compromised animals liver have different degrees of recovery, and what is had can return to normal level. General glycoside can improve body anoxic conditions by strengthening liver cell metabolic function, strengthen body energy, general glycoside can also suppress Peroxidatic reaction of lipid caused by alcohol induced or acetophenone, so that play a good protective effect to damaged liver, radix cynanchi bungei Effects of dispelling effects of alcohol and protecting liver just come from this.
The bletilla striata, (scientific name：Bletilla striata) also known as Lian Jicao, Gan Gen, give free of charge.《Sheng Nong's herbal classic》：" main carbuncle Swollen, malignant sore, lose subcutaneous ulcer, the dead flesh of impairment of yin, perverse trend in stomach ".Major function：Astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, wound Bleeding, sore swollen toxin, chapped skin；Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.
Sun-dried ginseng is after fresh ginseng is cleaned up, with drying equipment, the ginseng of drying.Ginseng (Panax ginseng C.A.Mey it is) herbaceos perennial, cures mainly：Physically weak to be taken off, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung breathes with cough, and injury thirst is interior Heat is quenched one's thirst, and prolonged illness void is thin, insomnia of palpitating with fear, impotence Gong Leng；Heart failure, cardiogenic shock.Detoxication ten of the ginseng to ethanol Clearly demarcated aobvious, it can not only shorten the duration of ethanol anesthesia and accelerate to recover the normal time, moreover it is possible to reduce GOT in serum, GPT, ALP and bilirubin equal size, and the activity of the alcohol dehydrogenase related with alcohol metabolism and aldehyde dehydrogenase can be increased, at the same time Noxious material acetaldehyde caused by alcohol metabolism is promptly excreted, due also to excessive hydrogen participates in saponin synthesis so as to have The liver of effect ground protection ethylism.
Fevervine is the herb of madder wort fevervine, and summer harvesting herb, is dried.Its sweet in flavor, slight bitter, it is mild-natured.Tool There is the effect of expelling wind and removing dampness, analgesic antidotal, promoting digestion and removing indigestion, activating blood circulation and reducing swelling.For rheumatalgia, traumatic injury, traumatic pain Bitterly, liver and gall and stomach and intestine angina, indigestion, infantile malnutrition, bronchitis；It is used for dermatitis, eczema and sore swollen toxin outside.
Bupleurum Chinese (scientific name：Bupleurum chinense DC.) it is Umbelliferae, Bupleurum herbaceos perennial, function Cure mainly：Inducing diaphoresis is brought down a fever；Soothing liver-qi stagnation, rises and lifts yang-energy.Main fever caused by exogenous pathogens；Fevers and chills alternate；Malaria；Liver-depressed hypochondrium pain mammary swelling；Headache head It is dizzy；Irregular menstruation；The rectal prolapse of collapse from qi deficiency；The prolapse of uterus；Gastroptosis.
Raw radix scutellariae (Classification system：Scutellaria baicalensis Georgi), alias Radix Scutellariae, tsuchikane tea root, It is lamiaceae labiatae scutellaria herbaceos perennial.The root of radix scutellariae is used as medicine, bitter, cold in nature, have heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, Tocolysis and other effects.Cure mainly warm heat disease, the infection of the upper respiratory tract, cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, movement of the foetus The diseases such as uneasiness, hypertension, carbuncle swells furuncle sore.Radix scutellariae methanolic extract 1000mg/kg is injected intraperitoneally, to α-naphthyl isothiocyanate (ANIT) Caused rat hepatic lesion has inhibitory action, can inhibit the increase of serum bilirubin.
Galangal is the dry rhizome of zingiberaceous plant galangal Alpinia officinarum Hance.Effect is used for gastral cavity Abdomen crymodynia, gastrofrigid vomiting, belch acid regurgitation.
Rhodiola root (scientific name：Rhodiola rosea L.), alias：Rhodiola rosea, sweeps sieve agate boolean (Tibetan name) etc.；Work( It can cure mainly：There is the effect of tonifying Qi clearing lung-heat, intelligence development nourishing heart, controlling of bleeding with astringents, eliminating stasis to subdue swelling.Cure mainly deficiency of vital energy and physically weak, after being ill chilly, shortness of breath Weak, cough with lung heat, spitting of blood, leukorrhea diarrhea, traumatic injury etc..《Modern practical book on Chinese herbal medicine》Say that its effect has seven, i.e., " one, maincenter Inhibitory action.2nd, antifatigue effect.3rd, cardiac effect.4th, anti-inflammatory effect.5th, blood glucose rise effect is suppressed.6th, anti-peroxide Change acts on.7th, resisting microwave radiation acts on ".
Umbellate pore furgus this product is the dry sclerotia of On Polyporaceae umbellate pore furgus Polyporus umbellatus (Pers.) Fries. Function is with curing mainly：Clearing damp and promoting diuresis.For difficult urination, oedema, diarrhea, stranguria with turbid discharge, with.Grifola polysaccharide can significantly increase mouse T Breeder reaction and B cell breeder reaction to LPS of the cell to ConA.Grifola polysaccharide has obvious rush to the full splenocyte of mouse Mitosis.Liver pathological changes can be substantially prevented, SGPT vigor declines, liver 5'-nucleotidase, acid phosphamidon enzyme 6- phosphoric acid Glucose phosphate enzyme activity gos up.Also there is similar effect in vitro, show there is significant protective effect to liver.
Dark plum is the drying almost ripe fruit of rose department plant plum Prunus mume (Sieb.) Sieb.etZuce..《This Grass is through dredging》：The dark plum of Mei Shi, i.e. the present are most sour.《Through》Say：Heat impairing qi, evil visitor is in the heart, then gas superinverse and dysphoria, and the heart is for it It is uneasy.Dark plum is sour, can hold back superficial heat, and energy air-breathing returns member, therefore leads lower gas, except hot dysphoria and feels at ease.Diarrhea person, large intestine collapse ；Good saliva dry person, flaring up of deficient fire, body fluid deficiency；Sour energy hold back the fire of deficiency type, changes body fluid, Gu intestines take off, so main.Its main limb Body pain, hemiplegia meciless person, covers because moisture is dipped in channels and collaterals, then tendon and vessel is relaxed vertical, or pain is meciless；Liver governing tendons, sour in taste acting on the liver and nourishing the muscle and tendon, liver Support, then solid skeleton and pliable tendons, organ's tonneau and preceding demonstrate,prove is removed.
Poria cocos, mycota, Basidiomycota agaric subphylum, agaric guiding principle Aphyllophorales, Polyporaceae, Poria cocos category, Classification system For Wolfiporia cocos (Schw.) Ryv.＆Gibn.
Rhizome of cyrtomium, Classification system are Dryopteris crassirhizoma Nakai, are terrestrial fern, and root-like stock is sturdy straight Vertical, overgrown, keratin, odd number one returns pinnate compound leaf, and pinnule is in sickle shaped lanceolar, and there is serration at edge, and petiole is elongated close By brown fine, soft fur, grace is not lost during it is rough, has much the graceful bearing that there is finesse in sb.'s roughness, potted plant appreciation is often made by the person of raising flowers, is belonged to together potted plant Also have rhizome of Japanese Holly Fern, cyrtomium caryotideumPresl etc..Character:Rhizome of cyrtomium is terrestrial fern, and root-like stock is sturdy upright, overgrown, keratin, odd number one Pinnate compound leaf is returned, pinnule is in sickle shaped lanceolar, and there is a serration at edge, and petiole is elongated close by brown fine, soft fur, during it is rough not Grace is lost, the graceful bearing that there is finesse in sb.'s roughness is had much, potted plant appreciation is often made by the person of raising flowers, potted plant also rhizome of Japanese Holly Fern, ratchet is belonged to together and passes through Crowd etc..
Dried orange peel, alias：Orange peel, expensive old, red skin, yellow orange peel, wide orange peel, PERICARPIUM CITRI RETICULATAE, orange peel, citrus chachiensis hortorum.Dried orange peel is rue Section's plant tangerine and its ripe pericarp of variety.Evergreen dungarunga of tangerine or shrub, cultivate in hills, low mountain zone, rivers lake Pool bank or Plain.
Roud cardamon seed is also known as Amomum cardamomum, cardamom.For Zingiber herbaceos perennial Amomum cardamomum (Classification system：Cardamom) Fruit, 10-12 month fruits are in yellow green, not yet crack when take, remove remaining carpopodium dry make it is medicinal.Take net white peas or beans It is cool, impurity and shell are removed, net benevolence is taken, is Amomum cardamomum benevolence, takes net Amomum cardamomum, removes impurity.Pericarp is stripped, is Amomum cardamomum skin. Property and flavor of peppery and warm.There is the effect of regulating the flow of QI to ease the stomach, dry cold-dampness, relieving alcoholism.Can be treated for stomachache the diseases such as abdominal distension, gas gastric disorder causing nausea.
Psoralea corylifolia, (Classification system：Psoralea corylifolia Linn.) also known as：Fructus psoaleae, mother-in-law consolidate fat, Hu fragrant-flowered garlic Son.Belong to Rosales, the annual upright draft of pulse family, high 60-150cm.Leaf is single leaf, long 7-8mm；The long 2-4.5cm of petiole, leaf width Avette, inflorescence axillary, there is colored 10-30, and corolla yellow or blueness, petal substantially have valve handle, and vexil obovate, pod is avette, Flower, the fruiting period 7-10 months.Seed is used as medicine, and has tonifying kidney and strengthening yang, the function of good efficacy to suffering from a deficiency of the kidney, and can control the skin diseases such as psoriasis.
Radix glycyrrhizae, (Classification system：Glycyrrhiza uralensis Fisch) alias：State is old, Herba Hedyotis cantonensis, Glycyrrhiza Uralensis, Sweet tea root.Pulse family, Glycyrrhiza perennial herb, root is sturdy with root-like stock, is a kind of help Chinese herbal medicine.It is a kind of well to human body Medicine, medicinal part are root and rhizomes, and Medicinal Materials Characters root is in cylinder, 25~100 centimetres long, 0.6~3.5 centimetre of diameter.Crust It is elastic to differ, surface rufous or taupe brown.For rhizome in cylinder, there is bud scar on surface, has marrow in the middle part of section.Gas is micro-, it is sweet and It is special.Major function is clearing heat and detoxicating, expelling phlegm and arresting coughing, gastral cavity abdomen etc..Happiness is dark moist, the low dry climate of the long temperature of sunshine.Radix glycyrrhizae It is grown in arid, semiarid desert steppe, desert edge and loess hill area more.Root and root-like stock hyoscine.
Polygala (Classification system：Radix Polygalae) it is conventional Chinese medicine, it is recorded in earliest《Sheng Nong's herbal classic》, it is classified as Top grade, and be considered as supporting life key medicine, it is remote from milk wort polygala Polygala tenuifolia Willd. and ovum leaf The dry root of will P.sibirica L..It is warm-natured, it is bitter, pungent, there is tranquilize the mind and promote the intelligence, eliminating the phlegm, detumescence, for heart kidney not Insomnia and dreamful sleep, forgetful palpitation with fear, wandering caused by friendship, and expectoration is not well, sore swollen toxin, mastosis.
The stem of noble dendrobium (Classification system：Dendrobium nobile Lindl), also known as lofty or bottomless palpus, bracketplant, Lin Lan, golden hairpin China etc.. Stem is upright, and meat shape is plump, and slightly flat cylinder is 10~60 centimetres long, slightly up to 1.3 centimetres.Medicinal plant, property slightly sweet flavor are micro- It is salty, tremble with fear, return stomach, kidney, lung channel.Reinforcing stomach reg fluid, nourishing Yin and clearing heat.For impairment of yin body fluid deficiency, dry polydipsia, deficiency of food is retched, after being ill abnormal heat, Mesh is secretly unknown.
Schisandra chinensis is magnoliaceae schisandra (Classification system：Schisandra chinensis(Turcz.)Baill.) Or schisandra chinensis (Classification system：Schisandra sphenanthera Rehd.et Wils.) dry mature fruit.Before Person, which practises, claims " fructus schisandrae ", and the latter, which practises, claims " kadsura longepedunculata ".Pick when the fruit matures in the fall, dry or dried after steaming, remove fruit Stalk and impurity.Schisandra chinensis of the present invention can use fructus schisandrae or kadsura longepedunculata, preferably fructus schisandrae.
Wilsonii (latin name：Radix Acanthopanacis Senticosl), section belongs to：Araliaceae Acanthopanax, makes Use position：Root and root-like stock, are born in the woods of hillside and in the shrubbery of roadside；Medicine garden often has cultivation.It is distributed in Central China, East China, south China And southwest.Root skin wind-damp dispelling, strengthening the bones and muscles.
Compared with prior art, the present invention is creatively by the 25 taste medicinal material such as American Ginseng, hoveniae semoveniae semen, sun-dried ginseng, rhodiola root Chinese medicine composition is mixed and made into, is found through experiment, which has significant Dealcoholic sobering-up, prevention and treatment because of alcohol The effect of caused acute liver damage.Meanwhile each component is free of any chemical addition agent in inventive formulation, taking safety can Lean on, have no toxic side effect.
Animal experiment situation is as follows：
1st, experiment material
1.1st, liver-protecting sobering up prescription
Hoveniae semoveniae semen 20g, American Ginseng 5g, sun-dried ginseng 5g, cynanchum wilfordii 10g, rhodiola root 10g etc. are total to 25-component medicine, prescription medicine Material is purchased from pharmacy of Tongrentang, and it is spare to prepare water decoction (crude drug concentration is 1g/mL) in original side's ratio.Used according to animal pharmacological experiment Medicine translation method, it is unified in experiment that middle dosage is administered by 10g crude drugs/kg mouse weights design according to adult's routine administration amount, its 2 times of amounts are high dose, and 1/2 amount is low dosage.Before experiment medicine body is given by 0.25mL (liquid)/10g (mouse weight) with distilled water Product adjustment decocting agent concentration.
1.2nd, animal
Cleaning grade kunming mice, male, weight 18-22g, Chongqing Teng Xin Bioisystech Co., Ltd provide [SCXK (Chongqing) 2012-0008]。
1.3rd, medicine and reagent
Hai Wangjin cups piece (extra large Wang Jiankang developments in science and technology Co., Ltd production, lot number 20120503) is configured to 1.5g/kg seas Wang Jin cup aqueous solutions；56% (V/V) Red Star strong, colourless liquor distilled from sorghum (Hongxing Co., Ltd. Beijing produces, lot number 20120814).ALT is tried Agent box, AST kits, SOD kits, MDA kits (Bioengineering Research Institute is built up in Nanjing).
2nd, experimental method
2.1st, mouse seeks connections with experiment
50 male mices are taken, 5 groups is randomly divided into, every group 10, is divided into the high, medium and low dosage group of liver-protecting sobering up prescription, sea Wang Jin cups group and control group (distilled water), fasting 12h before experiment.After each group gavage 30min, difference gavage Red Star strong, colourless liquor distilled from sorghum 15mL/kg, vertical metal is online with being placed on mouse, records each mouse and seeks connections with the time in online.
2.2nd, mouse rights experiment
50 male mices are taken, 5 groups is randomly divided into, every group 10, is divided into the high, medium and low dosage group of liver-protecting sobering up prescription, sea Wang Jin cups group and control group (distilled water), fasting 12h before experiment.After each group gavage 30min, difference gavage Red Star strong, colourless liquor distilled from sorghum 15mL/kg, records each mouse righting response extinction time (tolerance time) and disappears the duration immediately.
2.3rd, mice drunk sleep experiments
50 male mices are taken, 5 groups is randomly divided into, every group 10, is divided into the high, medium and low dosage group of liver-protecting sobering up prescription, sea Wang Jin cups group and control group (distilled water), fasting 12h before experiment.After each group gavage 30min, difference gavage Red Star strong, colourless liquor distilled from sorghum 15mL/kg, observes mouse active situation immediately.Being creeped using small white mouse, unstable, rear abdomen mops floor, eye closing lazy move refers to as sleep (drunk) Mark, using freedom of movement, pliable legs, mental restoration as revival (sobering up) index, records mouse time for falling asleep and recovery time, meter Calculate sleep tolerance time (from time of the wine to sleep is filled) and duration (time from falling asleep revival).
2.4th, to the influence of alcoholic liver injury
60 male mices are taken, 6 groups is randomly divided into, every group 10, is divided into the high, medium and low dosage group of liver-protecting sobering up prescription, sea Wang Jin cups group, model group, normal group.Chow diet and drinking-water is given once daily, is connected with Red Star strong, colourless liquor distilled from sorghum by daily 15mL/kg dosage It is continuous to fill 2 weeks, establish alcohol-induced acute hepatic injury model.Before wine 30min, model group gives distilled water, remaining administration group Give corresponding medicine.Last gives wine 12h, and eyeball takes blood, and blood places 30min in room temperature.After blood clotting, 4 DEG C, 3000r/ Min centrifuges 15min, takes supernatant, the method detection Serum ALT and AST provided according to kit.Mouse liver 2g is weighed, is cut It is broken, 10% liver homogenate liquid is made of physiological saline 20mL, centrifuges 10min in 3000r/min, takes supernatant spare, according to examination Agent box provides method detection hepatic tissue SOD, MDA.
2.5th, statistical analysis
All experimental datas withRepresent, statistical analysis is carried out with SPSS22.0.Using each parameter of variance analysis The conspicuousness of difference, P ＜ 0.05 represent that difference has statistical significance.
3rd, experimental result
3.1st, the influence of ability is sought connections with mouse
Mouse seeks connections with that experimental result is as shown in table 1, and compared with the control group, each dosage group of liver-protecting sobering up prescription can significantly extend Mouse seeks connections with the time (P<0.01).
1 liver-protecting sobering up prescription of table mouse is sought connections with ability influence (N=10)
Compared with the control group,*P<0.05,**P<0.01
3.2nd, to the influence of small white mouse righting reflex recovery time
Mouse rights that experimental result is as shown in table 2, and compared with the control group, each dosage group of liver-protecting sobering up prescription can significantly extend Mouse sleeping duration and shortening righting reflex loss duration (P<0.01 or P<0.05).
2 liver-protecting sobering up prescription of table to small white mouse righting reflex recovery time influence (N=10)
Compared with the control group,*P<0.05,**P<0.01
3.3rd, to the influence of the mice drunk length of one's sleep
The results are shown in Table 3 for mice drunk sleep experiments, and compared with the control group, each dosage group of liver-protecting sobering up prescription can be notable Extend mice sleep latent time and shorten sleep time (P<0.01).
3 liver-protecting sobering up prescription of table to the mice drunk length of one's sleep influence (N=10)
Compared with the control group,*P<0.05,**P<0.01
3.4th, to the influence of Alcoholic Hepatic Injury
The experimental result influenced on alcoholic liver injury is as shown in table 4, compared with normal group, control group mice ALT and AST Horizontal significantly rise (P ＜ 0.01), SOD contents significantly reduce (P ＜ 0.01), and MDA contents significantly raise (P ＜ 0.01), show Chronic ethanol treated mice hepatic injury is notable, Models of Acute Alcoholic Liver Injury modeling success.Compared with the control group, liver-protecting sobering up prescription is each Dosage group can significantly reduce ALT the and AST contents (P in mice serum<0.01), significantly rise mouse liver SOD contents and Reduce the MDA contents (P of mouse liver<0.01), show that each dosage group of liver-protecting sobering up prescription can mitigate mouse because alcohol draws The acute liver damage risen.
4 liver-protecting sobering up prescription of table to Alcoholic Hepatic Injury influence (N=10)
Compared with the control group,*P<0.05,**P<0.01；Compared with normal group,#P<0.05,##P<0.01
Embodiment
With reference to embodiment, the present invention is further illustrated.
Embodiment 1：A kind of Chinese medicine composition with the alcoholic liver injury that relieves the effect of alcohol, prevents, by weight including following original Material medicine is made：American Ginseng 5g, hoveniae semoveniae semen 20g, sun-dried ginseng 5g, rhodiola root 10g, Poria cocos 30g, rhizome of cyrtomium 15g, dried orange peel 15g, roud cardamon seed 5g, psoralea corylifolia 15g, radix glycyrrhizae 10g, cynanchum wilfordii 20g, raw hawthorn 20g, galangal 15g, Bupleurum Chinese 20g, polygala 10g, stem of noble dendrobium 20g, Raw radix scutellariae 10g, umbellate pore furgus 30g, dark plum 30g, Radix Puerariae 30g, cordyceps sinensis 10g, bletilla striata 15g, fevervine 20g, fructus schisandrae 20g, wilsonii 20g.
The preparation method of the Chinese medicine composition comprises the following steps：
(1) American Ginseng, sun-dried ginseng, cordyceps sinensis, the bletilla striata, Radix Puerariae 15g, dark plum, radix glycyrrhizae, the stem of noble dendrobium, dried orange peel are crushed, mistake 80 mesh sieves, it is spare to obtain fine powder；
(2) by hoveniae semoveniae semen, rhodiola root, cynanchum wilfordii, fevervine, raw hawthorn, galangal, Bupleurum Chinese, raw radix scutellariae, umbellate pore furgus, white 8-15 times of cool benevolence, rhizome of cyrtomium, polygala, fructus schisandrae, wilsonii, Poria cocos, psoralea corylifolia, Radix Puerariae 15g deionized water, extract 2-3 Secondary, when each 1-3 is small, filtering, filtrate concentration, dry, pulverize, it is spare to obtain water extract；Recovery rate is according to the dry of 20%-25% Medicinal extract (i.e. water extract) calculates.According to prescription 295g medicinal material extracts × 20%=59g dry extracts, primary medicinal powder 125g is obtained, Reprocessing obtains (59g+125g) ÷ 0.2g=920 balls (not plus pharmaceutic adjuvant) plus 1000, ball is made in pharmaceutic adjuvant adjustment (0.2g/ balls).
(3) the Chinese medicine composition eating method and amount：Before wine half an hour and after drinking half an hour take, each 30-50 Grain.
Embodiment 2：A kind of Chinese medicine composition with the alcoholic liver injury that relieves the effect of alcohol, prevents, by weight including following original Material medicine is made：American Ginseng 10g, hoveniae semoveniae semen 20g, sun-dried ginseng 10g, rhodiola root 10g, Poria cocos 30g, rhizome of cyrtomium 15g, dried orange peel 15g, White Chloe Benevolence 10g, psoralea corylifolia 20g, radix glycyrrhizae 15g, cynanchum wilfordii 20g, raw hawthorn 20g, galangal 15g, Bupleurum Chinese 15g, polygala 15g, the stem of noble dendrobium 20g, raw radix scutellariae 20g, umbellate pore furgus 20g, dark plum 30g, Radix Puerariae 30g, cordyceps sinensis 3g, bletilla striata 20g, fevervine 20g, fructus schisandrae (or kadsura longepedunculata) 15g, wilsonii 20g.
The preparation method of the Chinese medicine composition comprises the following steps：
(1) American Ginseng, sun-dried ginseng, cordyceps sinensis, the bletilla striata, Radix Puerariae 15g, dark plum, radix glycyrrhizae, the stem of noble dendrobium, dried orange peel are crushed, mistake 80 mesh sieves, it is spare to obtain fine powder；
(2) by hoveniae semoveniae semen, rhodiola root, cynanchum wilfordii, fevervine, raw hawthorn, galangal, Bupleurum Chinese, raw radix scutellariae, umbellate pore furgus, white Cool benevolence, rhizome of cyrtomium, polygala, fructus schisandrae (or kadsura longepedunculata), wilsonii, Poria cocos, psoralea corylifolia, Radix Puerariae 15g with 8-15 times go from Sub- water, is extracted 2-3 time, and when each 1-3 is small, filtering, filtrate concentrates, and dry, pulverize, it is spare to obtain water extract；Recovery rate according to The dry extract of 20%-25% calculates.Primary medicinal powder 138g is obtained according to prescription 300g medicinal material extracts × 20%=60g dry extracts, Reprocessing obtains (60g+138g) ÷ 0.4g=495 pieces (for full medicinal extract piece), can be according to effective because Chinese medical concrete does piece agent How much is component content, and the 20%-50% of total amount is risen to pharmaceutic adjuvant adjustment amplitude, therefore adds pharmaceutic adjuvant adjustment to be pressed into Tablet can be set to 600-1000 pieces (0.4g/ pieces).
(3) the Chinese medicine composition eating method and amount：Before wine half an hour and after drinking half an hour take, each 10-15 Piece.
Embodiment 3：A kind of Chinese medicine composition with the alcoholic liver injury that relieves the effect of alcohol, prevents, by weight including following original Material medicine is made：American Ginseng 10g, hoveniae semoveniae semen 10g, sun-dried ginseng 10g, rhodiola root 10g, Poria cocos 5g, rhizome of cyrtomium 3g, dried orange peel 5g, roud cardamon seed 3g, psoralea corylifolia 5g, radix glycyrrhizae 5g, cynanchum wilfordii 8g, raw hawthorn 5g, galangal 5g, Bupleurum Chinese 5g, polygala 5g, stem of noble dendrobium 8g, raw radix scutellariae 8g, umbellate pore furgus 8g, dark plum 8g, Radix Puerariae 10g, cordyceps sinensis 3g, bletilla striata 5g, fevervine 5g, fructus schisandrae 5g, wilsonii 8g.
The preparation method of the Chinese medicine composition comprises the following steps：
(1) American Ginseng, sun-dried ginseng, cordyceps sinensis, the bletilla striata, Radix Puerariae 5g, dark plum, radix glycyrrhizae, the stem of noble dendrobium, dried orange peel are crushed, mistake 80 mesh sieves, it is spare to obtain fine powder；
(2) by hoveniae semoveniae semen, rhodiola root, cynanchum wilfordii, fevervine, raw hawthorn, galangal, Bupleurum Chinese, raw radix scutellariae, umbellate pore furgus, white 8-15 times of cool benevolence, rhizome of cyrtomium, polygala, fructus schisandrae, wilsonii, Poria cocos, psoralea corylifolia, Radix Puerariae 5g deionized water, extract 2-3 Secondary, when each 1-3 is small, filtering, filtrate concentration, dry, pulverize, it is spare to obtain water extract；Recovery rate is according to the dry of 20%-25% Medicinal extract calculates.Primary medicinal powder 69g is obtained according to prescription 113g medicinal material extracts × 20%=22.6g dry extracts, reprocessing obtains (22.6g+69g) ÷ 0.4g=229 pieces (for full medicinal extract piece), can be more according to effective component content because Chinese medical concrete does piece agent It is few, the 20%-50% of total amount is risen to pharmaceutic adjuvant adjustment amplitude, therefore add pharmaceutic adjuvant adjustment is tabletted to be set to 280-350 pieces (0.4g/ pieces).
(3) the Chinese medicine composition eating method and amount：Before wine half an hour and after drinking half an hour take, each 10-15 Piece.

Claims (5)

  1. A kind of 1. Chinese medicine composition with the alcoholic liver injury that relieves the effect of alcohol, prevents, it is characterised in that：By weight by following raw material Medicine is made：10-100 parts of American Ginseng, 10-100 parts of hoveniae semoveniae semen, 10-100 parts of sun-dried ginseng, 10-100 parts of rhodiola root, Poria cocos 10-80 Part, 10-30 parts of rhizome of cyrtomium, 10-50 parts of dried orange peel, 10-30 parts of roud cardamon seed, 10-80 parts of psoralea corylifolia, 10-80 parts of radix glycyrrhizae, cynanchum wilfordii 10- 100 parts, it is 10-100 parts of raw hawthorn, 10-100 parts of galangal, 10-100 parts of Bupleurum Chinese, 10-50 parts of polygala, 10-80 parts of the stem of noble dendrobium, raw 10-100 parts of radix scutellariae, 10-100 parts of umbellate pore furgus, 10-100 parts of dark plum, 10-150 parts of Radix Puerariae, 10-100 parts of cordyceps sinensis, the bletilla striata 10-100 parts, 10-100 parts of fevervine, 10-50 parts of fructus schisandrae, 10-100 parts of wilsonii.
  2. 2. the Chinese medicine composition with the alcoholic liver injury that relieves the effect of alcohol, prevents according to claim 1, it is characterised in that：Press Parts by weight are made by following bulk pharmaceutical chemicals：100 parts of American Ginseng, 100 parts of hoveniae semoveniae semen, 100 parts of sun-dried ginseng, 100 parts of rhodiola root, Poria cocos 50 Part, 30 parts of rhizome of cyrtomium, 50 parts of dried orange peel, 30 parts of roud cardamon seed, 50 parts of psoralea corylifolia, 50 parts of radix glycyrrhizae, 80 parts of cynanchum wilfordii, 50 parts of raw hawthorn, height 50 parts of galingal, 50 parts of Bupleurum Chinese, 50 parts of polygala, 80 parts of the stem of noble dendrobium, raw 80 parts of radix scutellariae, 80 parts of umbellate pore furgus, 80 parts of dark plum, Radix Puerariae 100 Part, 30 parts of cordyceps sinensis, 50 parts of the bletilla striata, 50 parts of fevervine, 50 parts of fructus schisandrae, 80 parts of wilsonii.
  3. 3. the preparation method of the Chinese medicine composition according to claim 1 or 2 with the alcoholic liver injury that relieves the effect of alcohol, prevents, It is characterized in that：Comprise the following steps：
    （1）American Ginseng, sun-dried ginseng, cordyceps sinensis, the bletilla striata, the Radix Puerariae of 1/2 amount, dark plum, radix glycyrrhizae, the stem of noble dendrobium, dried orange peel are crushed, mistake 80 mesh sieves, it is spare to obtain fine powder；
    （2）By hoveniae semoveniae semen, rhodiola root, cynanchum wilfordii, fevervine, raw hawthorn, galangal, Bupleurum Chinese, raw radix scutellariae, umbellate pore furgus, roud cardamon seed, 8-15 times of deionized water of rhizome of cyrtomium, polygala, fructus schisandrae, wilsonii, Poria cocos, psoralea corylifolia and remaining Radix Puerariae, extracts 2-3 Secondary, when each 1-3 is small, filtering, filtrate concentration, dry, pulverize, it is spare to obtain water extract；
    （3）It is mixed together after fine powder and water extract mixing, then with pharmaceutic adjuvant, oral formulations is made according to a conventional method.
  4. Relieve the effect of alcohol 4. being had according to claim 1-3 any one of them Chinese medicine composition in preparation, prevent alcoholic liver injury Application in medicine.
  5. 5. there is the Chinese medicine composition for the alcoholic liver injury that relieves the effect of alcohol, prevents, its feature according to claim 1-3 any one of them It is：The formulation of the Chinese medicine composition is hard shell capsules, soft capsule, tablet, granule, powder or pill.
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CN114403328A (en) * 2021-10-17 2022-04-29 南京中医药大学 An anti-hangover beverage prepared from semen Hoveniae and radix Puerariae
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CN104413512A (en) * 2013-08-28 2015-03-18 吴会亮 Traditional-Chinese-medicine drunkenness-dispelling liver-protecting beverage
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