CN105796753A - Hepatoprotection traditional Chinese medicine composition and preparation method thereof - Google Patents
Hepatoprotection traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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- CN105796753A CN105796753A CN201610252614.8A CN201610252614A CN105796753A CN 105796753 A CN105796753 A CN 105796753A CN 201610252614 A CN201610252614 A CN 201610252614A CN 105796753 A CN105796753 A CN 105796753A
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- radix puerariae
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Abstract
The invention discloses a hepatoprotection traditional Chinese medicine composition and a preparation method thereof, and relates to the technical field of a traditional Chinese medicine composition. The hepatoprotection traditional Chinese medicine composition is prepared from radix astragali seu hedysari, herba centellae, radix puerariae, fructus schisandrae, semen hoveniae and fructus lycii. According to the preparation method, cleanly cleaned radix astragali seu hedysari, herba centellae, radix puerariae, fructus schisandrae, semen hoveniae and fructus lycii are extracted and concentrated. The traditional Chinese medicine composition has the efficacies of clearing away heat and toxic materials, protecting the liver, replenishing kidney essence and liver blood, nourishing the liver and the kidney, brightening the eyes, moisturizing the lung, stopping the cough, tranquilizing by nourishing the heart, regulating the immunity, delaying the senility and improving the memory after the matching.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine, especially one be used for protecting the liver, liver protection traditional Chinese medicine combination and preparation method thereof.
Background technology
The pollution of environment, drink, smoke, stay up late, diet unbalanced etc., cause that the sickness rate of hepatopathy is in the trend risen year by year, age of onset is also in constantly rejuvenation；For a long time, hepatopathy be always up shrouding the sickness rate of the dark clouds Chinese people hepatopathy on China's number of people occupy the world first, to such an extent as to a lot of people talks " hepatitis " complexion changed.Hepatopathy brings great puzzlement not only to our healthy living, and hepatopathy also results in multiple disease and issues licence, the even generation of induced hepatocellular carcinoma.The age occurred frequently of hepatocarcinoma, this was that this process is even up to as long as many decades owing to the effect of cancerigenic factor needs the process of an accumulation after 40 years old.So active prevention and treatment hepatopathy can reduce the generation of hepatocarcinoma to a certain extent." whole world cancer report 2014 " display that World Health Organization (WHO) delivers, the newly-increased cases of cancer height of China ranks first in the world, and wherein the new cases of hepatocarcinoma and death toll all occupy first place in the world.At present, the sickness rate of China's hepatocarcinoma is about 25.7/10 ten thousand, becomes mortality rate and is only second to the third-largest malignant tumor of gastric cancer, pulmonary carcinoma.Primary hepatocarcinoma onset is hidden, and early stage lacks classical symptom.
Along with the demand that society is social is increasing and the formation of Bad Eating Habit, alcoholic liver injury ratio in hepatopathy increases day by day, in the course of time, will bring out the generation of hepatitis, hepatocarcinoma etc..
Summary of the invention
One of problem that this invention address that is to provide a kind of liver protection traditional Chinese medicine combination with hepatoprotective effect.
In order to solve above-mentioned technical problem, the technical solution adopted in the present invention is: it is made up of the raw material of following weight percents:
The Radix Astragali 25%～35%, Herba Centellae 25%～35%, Radix Puerariae 10%～20%, Fructus Schisandrae Chinensis 5%～15%, Japanese raisintree fruit 3%～8%, Fructus Lycii 5%～15%.
The preparation method that the two of problem to be solved by this invention are to provide the good liver protection traditional Chinese medicine combination of a kind of manufacture method pharmacy effect that is simple and that obtain.
In order to solve above-mentioned technical problem, the technical solution adopted in the present invention is:
Adopt the raw material of following percentage by weight:
The Radix Astragali 25%～35%, Herba Centellae 25%～35%, Radix Puerariae 10%～20%, Fructus Schisandrae Chinensis 5%～15%, Japanese raisintree fruit 3%～8%, Fructus Lycii 5%～15%；
Making step is:
A, the silt by the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii, impurity, non-medicinal effects remove；
B, claim the weight of the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii respectively by the weight percentage ranges of above-mentioned raw materials, standby；
C, undertaken extracting, concentrating by the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii.
In technique scheme, scheme is it may also is that in step C more specifically, extracting method is: be placed in extraction pot by the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii, add 10 times amount water boiling and extraction respectively twice, decoct every time and extract 2.0 hours, the extracting solution obtained is filtered, and twice filtrate is merged；During concentration, temperature controls 60～85 DEG C, vacuum degree control-0.09～0.06Mpa, is concentrated into relative density and is 1.3(60 DEG C) thick paste.
Further: in step C, extracting method is: by Radix Puerariae with the ethanol extraction of 7 times amount 70% once, extract 1 hour, is filtered by extracting solution, and filtrate concentrates；Being mixed with the Radix Astragali, Herba Centellae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii by Radix Puerariae medicinal residues, continue to add 10 times amount water boiling and extraction twice, decoct every time and extract 2.0 hours, filtered respectively by extracting solution, twice filtrate merges, concentration；Again two kinds of concentrated solutions are mixed, reconcentration；When concentrating for the last time, temperature controls 60～85 DEG C, vacuum degree control-0.09～0.06Mpa, is concentrated into relative density and is 1.3(60 DEG C) thick paste.
Further: in step C, extracting method is: by the Radix Puerariae ethanol extraction twice of 7 times amount 70%, extracting 1.5 hours every time, filtered by extracting solution, filtrate concentrates；Being mixed with the Radix Astragali, Herba Centellae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii by Radix Puerariae medicinal residues, continue to add 10 times amount water boiling and extraction twice, decoct every time and extract 2.0 hours, filtered respectively by extracting solution, twice filtrate merges, concentration；Again two kinds of concentrated solutions are mixed, reconcentration；When concentrating for the last time, temperature controls 60～85 DEG C, vacuum degree control-0.09～0.06Mpa, is concentrated into relative density and is 1.3(60 DEG C) thick paste.
Herba Centellae described in the present invention, pharmacopeia [nature and flavor with return through] bitter, acrid, cold.Return liver,spleen,kidney warp.Cure mainly clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For jaundice due to damp-heat, heatstroke is suffered from diarrhoea, sand Stranguria stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.It is the long-lived medicine of Asians, can refresh oneself by benefit brain.Research shows have nourishing, antiinflammatory, healing of wound, diuresis relieving constipation and calm effect.Leprosy, ulcer is also effective in cure, blood purification and immunity there are is activation, because it can stimulate the replacement of deep skin cell.It is neural nourishing agent, can improve memory, alleviate mental fatigue；Also can blood pressure lowering, treatment hepatopathy etc..Energy clearing away lung-heat to relieve cough, parasite killing relieving constipation, nourishing YIN are quenched the thirst.Control cough due to lung-heat, parasitic disease, constipation, quench one's thirst.1. " decoction pieces is newly joined ": lung heat clearing, only consumptive disease is coughed, parasite killing, logical stool.The place of production is in Guangxi, and lung heat clearing relieving constipation removing heat from blood, for principal agent.
The Radix Astragali described in the present invention, modern medicine study shows, the Radix Astragali has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and wide antibacterial action.The Radix Astragali can not only coronary artery dilator, improve blood supply of cardiac muscle, improve immunologic function, and can the process of delaying cell aging.There is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and bursts for a long time and does not hold back, and blood deficiency and yellow complexion, interior-heat is quenched one's thirst." herbal classic " is recorded: " main carbuncle loses skin ulcer, evacuation of pus pain relieving for a long time.Qi-restoratives, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas strengthening bone and muscle, put on flesh and enrich blood.”
From the Radix Astragali, separating-purifying goes out effective ingredient astragalus polysaccharides (APS), and pharmacological research finds, APS can reduce glucose load; the mouse blood sugar that antiadrenergic drug is caused raises; there is adjustment blood glucose, protect cardiovascular system, improve the effect of myocardial ischemic injury.Clinical observation, can effectively reduce blood glucose with APS Chongji for Treatment type 2 diabetes mellitus patient, and can improve spiritlessness and weakness, palpitation and insomnia symptom.The coumarin isoreactivity composition that the Radix Astragali contains also has reduction blood glucose effect; SOD activity in old human blood can be significantly improved; i.e. superoxide dismutase, has and reduces free radical generation or increase the elimination effect to free radical, islet cells etc. is had significant protective effect.
Many animals is all had hypotensive effect by the Radix Astragali.Spontaneous hypertensive rat gavage Astragalus membranaceus can make the ascensional range of blood pressure control to some extent.The antihypertensive compositions of the Radix Astragali is γ-aminobutyric acid and Astragalus Saponin I.When animal blood pressure is down to shock level, the Radix Astragali can make again blood pressure slightly rise and remain stable for, and blood pressure has certain dual regulation.The Radix Astragali can substantially reduce the resistance of the cerebrovascular of anesthetized dog, peripheral blood vessel, coronary artery, superior mesenteric artery, and the blood vessel at these positions is had dilating effect.
Radix Puerariae described in the present invention, in pharmacopeia function with cure mainly: expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, yang invigorating antidiarrheal, logical
Channels and activating collaterals, alcoholic intoxication.Have a headache for fever caused by exogenous pathogens, stiff nape and back, thirsty; quench one's thirst, measles without adequate eruption, hematodiarrhoea; have loose bowels, dizziness and headache, apoplectic hemiplegia; obstruction of qi in the chest and cardialgia; damage of the spleen and stomach caused by alcoholism, is traditional antialcoholic drugs, and acute liver damage is had protective effect by its composition puerarin; can knowing oxygen-derived free radicals with it, anti peroxidation of lipid hydrogen effect is relevant.
Carry in Compendium of Material Medica: cool in nature, gas is put down, sweet in the mouth, has heat clearing away, pathogenic fire reducing, all effects of toxin expelling.Modern medicine study shows: hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease are had certain curative effect by the isoflavonoid puerarin in Radix Puerariae.
Fructus Schisandrae Chinensis described in the present invention, warm in nature, sour in the mouth, lung, the heart, liver, kidney channel can be entered, its effect mainly has QI invigorating convergence, tranquilizing by nourishing the heart, the kidney invigorating arresting seminal emission, YIN nourishing nourishing the liver.Its extract and extracting solution have hepatoprotective, anti-ageing effect of waiting for a long time.The serum glutamic pyruvic transminase that hepatic injury is caused raises reduction effect; if glutamate pyruvate transaminase raise, can with jaundice, and receive food poor; often feel sick, abdominal distention, the obvious people of damp-heat in the spleen and stomach such as stool is irregular, thick fur is greasy, he drinks, with Fructus Schisandrae Chinensis is soaked, liver-protective effect of usually can playing.Hepatic injury caused by chemical toxicant is had protective effect by Fructus Schisandrae Chinensis, simultaneously, it is possible to strengthen hepatocellular regeneration function, resists the lipid peroxidation of liver, thus hepatoprotective.Fructus Schisandrae Chinensis is not only applicable to the treatment of the cough with asthma of chronic cough of deficiency lung or lung kidney deficiency, aspect of having a sleepless night, protect the liver etc., also progressively applies the auxiliary treatment of cardiovascular disease, antioxidation resisting fatigue, oral ulcer and tumor.Fructus Schisandrae Chinensis is the Chinese medicine commonly used clinically, and head is loaded in Shennong's Herbal, is classified as top grade.Say: " Fructus Schisandrae Chinensis, sour in the mouth, temperature.Main QI invigorating, cough with dyspnea, impairment caused by overstrain is frail, tonifying for the deficiency, reinforcing YIN-essence, benefit man's essence.Raw mountain valley, Mt. Qishan.”
Japanese raisintree fruit described in the present invention, the flat sweet in the mouth of property, nontoxic, have relieving restlessness of quenching the thirst, go heat on diaphragm, moistening five ZANG-organs, profit defecation, have relieve the effect of alcohol, protect the liver, anti-hepatic fibrosis and aging, fatigue-resisting function.It contains the compositions such as saponin, flavonoid, alkaloid, non-alcoholic fatty liver disease has definite curative effect, and its extract can alleviate Liver Collagen fibroplasia degree, has anti-Early hepatic fibrosis effect, hepatocyte survival and appreciation rate can be significantly improved, hepatocyte is had promotion growth activity.
Fructus Lycii described in the present invention, is the medicine food product with use, the flat sweet in the mouth of property; return liver, kidney channel; can flat the kidney invigorating essence liver blood, can nourishing the liver and kidney, improving eyesight, nourishing the lung to arrest cough, Fructus Lycii can be also used for preventing and treating diabetes, hyperlipemia, hepatopathy and tumor; strengthen and regulate immunologic function, the liver protecting; slow down aging, it is possible to promote the phagocytic function of macrophage in organism, reduce the deposition of fatty brown element; the formation of the lipid peroxide in suppression liver, reduces cholesterol and triglyceride.Liver is synthetic cholesterol and the maximum place of neutral fat, the Organic substance energy the liver protecting of Fructus Lycii, it is suppressed that fat is hoarded in liver, promotes the activation of cell, the hepatocyte that maintenance is impaired.
Summary, Herba Centellae bitter in the mouth is pungent, cold in nature, clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, and the Radix Astragali is warm in nature, sweet in the mouth, returns lung, spleen channel, invigorating QI to consolidate the body surface resistance, holds back diuresis poison holding, skin ulcer granulation promoting, and both share, and one can restrict the property that medicine-feeding is bitter cool；Two effects that can help medicine-feeding heat-clearing and toxic substances removing；Fructus Schisandrae Chinensis is warm in nature, Fructus Lycii taste levelling is sweet, and both share and can strengthen immunoloregulation function, slow down aging, strengthens liver-protecting function；Radix Puerariae sweet in the mouth cool in nature, has promoting the production of body fluid to quench thirst, can solve the effect of " alcoholism "；The flat sweet in the mouth of Japanese raisintree fruit, " special alcoholic intoxication ", both of which belongs to " integration of edible and medicinal herbs " plant, the two compatibility can antioxidation, promote metabolism nutrient, hepatic injury is had protective effect.
Owing to adopting technique scheme, there is advantages that
1, not only there is after the kinds of traditional Chinese medicines compatibility in this compositions effect of heat-clearing and toxic substances removing, hepatoprotective, additionally it is possible to can flat the kidney invigorating essence liver blood, can nourishing the liver and kidney, improving eyesight, nourishing the lung to arrest cough, tranquilizing by nourishing the heart, can regulate again immunity, slow down aging, improve memory.
2, nontoxic, have no side effect, be pure Chinese medicinal preparation, it does not have add any compound.
3. it is easy to carry, taking convenience, simply.
4. cost is low, economical and practical: the medical material in the present invention is common Chinese medicine material, and the source of goods is abundant, cheap and purchase convenience, more more economical practicality than similar drugs.
Detailed description of the invention
Below in conjunction with example, the invention will be further described, but the present invention is not limited to this:
Embodiment 1:
Weigh the medical material of following weight:
Herba Centellae 35 kilograms, the Radix Astragali 30 kilograms, Radix Puerariae 20 kilograms, Fructus Schisandrae Chinensis 10 kilograms, Japanese raisintree fruit 6 kilograms, Fructus Lycii 8 kilograms；
Its preparation process is:
A, the silt by the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii, impurity, non-medicinal effects remove；
B, claim the weight of the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii respectively by the weight percentage ranges of above-mentioned raw materials, standby；
C, the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii are extracted, its extracting method is: be placed in extraction pot by the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii, add 10 times amount water boiling and extraction respectively twice, first time first soaks 30 minutes before decocting, decoct every time and extract 2.0 hours, the extracting solution obtained is filtered, twice filtrate is merged；During concentration, temperature controls between 60～85 DEG C, and vacuum degree control, between-0.09～0.06Mpa, is concentrated into relative density and is 1.3(60 DEG C) thick paste, in vacuum drying pallet, thick paste is dried to dry cream.
Embodiment 2:
Herba Centellae 35 kilograms, the Radix Astragali 30 kilograms, Radix Puerariae 20 kilograms, Fructus Schisandrae Chinensis 10 kilograms, Japanese raisintree fruit 6 kilograms, Fructus Lycii 8 kilograms；
Its preparation process is:
A, the silt by the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii, impurity, non-medicinal effects remove；
B, claim the weight of the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii respectively by the weight percentage ranges of above-mentioned raw materials, standby；
C, the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii being extracted, extracting method is: by Radix Puerariae with the ethanol extraction of 7 times amount 70% once, first soaks 30 minutes before extraction, extracts 1 hour, is filtered by extracting solution, and filtrate concentrates；Being mixed with the Radix Astragali, Herba Centellae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii by Radix Puerariae medicinal residues, continue to add 10 times amount water boiling and extraction twice, decoct every time and extract 2.0 hours, filtered respectively by extracting solution, twice filtrate merges, concentration；Again two kinds of concentrated solutions are mixed, reconcentration；When concentrating for the last time, temperature controls at 60～85 DEG C, and vacuum degree control, at-0.09～0.06Mpa, is concentrated into relative density and is 1.3(60 DEG C) thick paste, in vacuum drying pallet, thick paste is dried to dry cream.
Embodiment 3:
Adopt the medical material of following weight:
Herba Centellae 25 kilograms, the Radix Astragali 25 kilograms, Radix Puerariae 10 kilograms, Fructus Schisandrae Chinensis 15 kilograms, Japanese raisintree fruit 4 kilograms, Fructus Lycii 10 kilograms；
Making step is:
A, the silt by the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii, impurity, non-medicinal effects remove；
B, claim the weight of the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii respectively by the weight percentage ranges of above-mentioned raw materials, standby；
C, the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii being extracted, extracting method is: by Radix Puerariae with the ethanol extraction of 7 times amount 70% once, first soaks 30 minutes before extraction, extracts 1 hour, is filtered by extracting solution, and filtrate concentrates；Being mixed with the Radix Astragali, Herba Centellae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii by Radix Puerariae medicinal residues, continue to add 10 times amount water boiling and extraction twice, decoct every time and extract 2.0 hours, filtered respectively by extracting solution, twice filtrate merges, concentration；Again two kinds of concentrated solutions are mixed, reconcentration；When concentrating for the last time, temperature controls at 60～85 DEG C, and vacuum degree control, at-0.09～0.06Mpa, is concentrated into relative density and is 1.3(60 DEG C) thick paste, in vacuum drying pallet, thick paste is dried to dry cream.
Embodiment 4:
Adopt the medical material of following weight:
Herba Centellae 25 kilograms, the Radix Astragali 25 kilograms, Radix Puerariae 10 kilograms, Fructus Schisandrae Chinensis 15 kilograms, Japanese raisintree fruit 4 kilograms, Fructus Lycii 10 kilograms；
Its preparation process is:
A, the silt by the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii, impurity, non-medicinal effects remove；
B, claim the weight of the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii respectively by the weight percentage ranges of above-mentioned raw materials, standby；
C, the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii being extracted, extracting method is: by the Radix Puerariae ethanol extraction twice of 7 times amount 70%, extracting 1.5 hours every time, filtered by extracting solution, filtrate concentrates；Being mixed with the Radix Astragali, Herba Centellae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii by Radix Puerariae medicinal residues, continue to add 10 times amount water boiling and extraction twice, decoct every time and extract 2.0 hours, filtered respectively by extracting solution, twice filtrate merges, concentration；Again two kinds of concentrated solutions are mixed, reconcentration；When concentrating for the last time, temperature controls 60～85 DEG C, vacuum degree control-0.09～0.06Mpa, is concentrated into relative density and is 1.3(60 DEG C) thick paste, in vacuum drying pallet, thick paste is dried to dry cream.
Embodiment 5:
Adopt the medical material of following weight:
Herba Centellae 30 kilograms, the Radix Astragali 35 kilograms, Radix Puerariae 15 kilograms, Fructus Schisandrae Chinensis 12 kilograms, Japanese raisintree fruit 8 kilograms, Fructus Lycii 15 kilograms；
Its preparation process is:
A, the silt by the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii, impurity, non-medicinal effects remove；
B, claim the weight of the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii respectively by the weight percentage ranges of above-mentioned raw materials, standby；
C, the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii are extracted, its extracting method is: be placed in extraction pot by the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii, add 10 times amount water boiling and extraction respectively twice, first time first soaks 30 minutes before decocting, decoct every time and extract 2.0 hours, the extracting solution obtained is filtered, twice filtrate is merged；During concentration, temperature controls between 60～85 DEG C, and vacuum degree control, between-0.09～0.06Mpa, is concentrated into relative density and is 1.3(60 DEG C) thick paste, in vacuum drying pallet, thick paste is dried to dry cream.
Embodiment 6:
Adopt the raw material of following weight:
Herba Centellae 30 kilograms, the Radix Astragali 35 kilograms, Radix Puerariae 15 kilograms, Fructus Schisandrae Chinensis 12 kilograms, Japanese raisintree fruit 8 kilograms, Fructus Lycii 15 kilograms；
Its preparation process is:
A, the silt by the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii, impurity, non-medicinal effects remove；
B, claim the weight of the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii respectively by the weight percentage ranges of above-mentioned raw materials, standby；
C, the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii being extracted, its extracting method is extracting method is: by the ethanol extraction twice of Radix Puerariae 7 times amount 70%, extracting 1.5 hours every time, filtered by extracting solution, filtrate concentrates；Being mixed with the Radix Astragali, Herba Centellae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii by Radix Puerariae medicinal residues, continue to add 10 times amount water boiling and extraction twice, decoct every time and extract 2.0 hours, filtered respectively by extracting solution, twice filtrate merges, concentration；Again two kinds of concentrated solutions are mixed, reconcentration；When concentrating for the last time, temperature controls 60～85 DEG C, vacuum degree control-0.09～0.06Mpa, is concentrated into relative density and is 1.3(60 DEG C) thick paste, in vacuum drying pallet, thick paste is dried to dry cream.
Clinical trial part:
One, the pharmacological experiment containing liver protection traditional Chinese medicine combination
Adopt carbon tetrachloride hepatic injury modelling modeling, the Kunming mouse that 80 body weight are 20-25g is randomly divided into 8 groups, respectively Normal group, model control group and embodiment 1-6 experimental group, 6 experimental group mouse stomaches every day give corresponding tested material 1 time, tested material concentration is 4g/ml/, every day 4.5g/kg；Normal group and model control group gavage every day mice give distilled water, give continuously 30 days, weigh weekly twice and adjust dosage according to body weight.Then liver is gone to check the content of the malonaldehyde (MDA) in liver homogenate, reduced glutathion (GSH) and triglyceride (TG).Institute total carries out statistical analysis, statistically significant for difference with P < 0.05.
Result is in Table 1:
Table 1 is respectively organized liver homogenate malonaldehyde (MDA), reduced glutathion (GSH) and triglyceride (TG) level and is compared (X ± s)
As can be seen from the above data, when carbon tetrachloride hepatic injury model is set up, the TG content of six tested group is significantly lower than model control group (P < 0.05), and the MDA content of six tested group is significantly lower than model control group (P < 0.05).
Above it have been experienced that, chemical liver injury is had assistant protection function by this Chinese medicine composition.
Claims (5)
1. a liver protection traditional Chinese medicine combination, it is characterised in that it is made up of the raw material of following weight percents:
The Radix Astragali 25%～35%, Herba Centellae 25%～35%, Radix Puerariae 10%～20%, Fructus Schisandrae Chinensis 5%～15%, Japanese raisintree fruit 3%～8%, Fructus Lycii 5%～15%.
2. the preparation method of a liver protection traditional Chinese medicine combination, it is characterised in that:
Adopt the raw material of following percentage by weight:
The Radix Astragali 25%～35%, Herba Centellae 25%～35%, Radix Puerariae 10%～20%, Fructus Schisandrae Chinensis 5%～15%, Japanese raisintree fruit 3%～8%, Fructus Lycii 5%～15%；
Making step is:
A, the silt by the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii, impurity, non-medicinal effects remove；
B, claim the weight of the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii respectively by the weight percentage ranges of above-mentioned raw materials, standby；
C, undertaken extracting, concentrating by the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii.
3. the preparation method of Chinese medicine composition according to claim 2, it is characterised in that:
In step C, extracting method is: be placed in extraction pot by the Radix Astragali, Herba Centellae, Radix Puerariae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii, adds 10 times amount water boiling and extraction respectively twice, decocts every time and extracts 2.0 hours, and the extracting solution obtained is filtered, and twice filtrate is merged；During concentration, temperature controls 60～85 DEG C, vacuum degree control-0.09～0.06Mpa, is concentrated into relative density and is 1.3(60 DEG C) thick paste.
4. the preparation method of Chinese medicine composition according to claim 2, it is characterised in that:
In step C, extracting method is: by Radix Puerariae with the ethanol extraction of 7 times amount 70% once, extract 1 hour, is filtered by extracting solution, and filtrate concentrates；Being mixed with the Radix Astragali, Herba Centellae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii by Radix Puerariae medicinal residues, continue to add 10 times amount water boiling and extraction twice, decoct every time and extract 2.0 hours, filtered respectively by extracting solution, twice filtrate merges, concentration；Again two kinds of concentrated solutions are mixed, reconcentration；When concentrating for the last time, temperature controls 60～85 DEG C, vacuum degree control-0.09～0.06Mpa, is concentrated into relative density and is 1.3(60 DEG C) thick paste.
5. the preparation method of Chinese medicine composition according to claim 2, it is characterised in that:
In step C, extracting method is: by the Radix Puerariae ethanol extraction twice of 7 times amount 70%, extracting 1.5 hours every time, filtered by extracting solution, filtrate concentrates；Being mixed with the Radix Astragali, Herba Centellae, Fructus Schisandrae Chinensis, Japanese raisintree fruit, Fructus Lycii by Radix Puerariae medicinal residues, continue to add 10 times amount water boiling and extraction twice, decoct every time and extract 2.0 hours, filtered respectively by extracting solution, twice filtrate merges, concentration；Again two kinds of concentrated solutions are mixed, reconcentration；When concentrating for the last time, temperature controls 60～85 DEG C, vacuum degree control-0.09～0.06Mpa, is concentrated into relative density and is 1.3(60 DEG C) thick paste.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106360820A (en) * | 2016-11-18 | 2017-02-01 | 陕西汉中秦辉生物医药科技有限公司 | Traditional-Chinese-medicine bra for preventing and treating breast diseases |
| CN107594225A (en) * | 2017-10-27 | 2018-01-19 | 无锡华诺威动物保健品有限公司 | A kind of feed addictive of fish liver health and preparation method thereof |
| CN108056470A (en) * | 2016-11-07 | 2018-05-22 | 河北以岭医药研究院有限公司 | A kind of health food containing centella and preparation method thereof |
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| CN1528429A (en) * | 2003-10-20 | 2004-09-15 | 上海澳博海洋生物技术开发有限公司 | Chinese medicine preparation with accessory protection action to alcoholic liver injury and preparing method thereof |
| CN102670763A (en) * | 2012-06-01 | 2012-09-19 | 广州市奥海生物科技有限公司 | Composition with auxiliary protection effect on chemical liver injury and preparation method of composition |
| CN104435296A (en) * | 2014-11-29 | 2015-03-25 | 张莘蔓 | Traditional Chinese medicine composition preparation containing asiatic pennywort herb |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528429A (en) * | 2003-10-20 | 2004-09-15 | 上海澳博海洋生物技术开发有限公司 | Chinese medicine preparation with accessory protection action to alcoholic liver injury and preparing method thereof |
| CN102670763A (en) * | 2012-06-01 | 2012-09-19 | 广州市奥海生物科技有限公司 | Composition with auxiliary protection effect on chemical liver injury and preparation method of composition |
| CN104435296A (en) * | 2014-11-29 | 2015-03-25 | 张莘蔓 | Traditional Chinese medicine composition preparation containing asiatic pennywort herb |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108056470A (en) * | 2016-11-07 | 2018-05-22 | 河北以岭医药研究院有限公司 | A kind of health food containing centella and preparation method thereof |
| CN106360820A (en) * | 2016-11-18 | 2017-02-01 | 陕西汉中秦辉生物医药科技有限公司 | Traditional-Chinese-medicine bra for preventing and treating breast diseases |
| CN107594225A (en) * | 2017-10-27 | 2018-01-19 | 无锡华诺威动物保健品有限公司 | A kind of feed addictive of fish liver health and preparation method thereof |
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Application publication date: 20160727 |