CN103463456B - Traditional Chinese medicine composition and preparation method thereof - Google Patents
Traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition which has synergistic interaction for improving body immunity, building body and nourishing skin, and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 5-60 parts of donkey-hide gelatin, 2-30 parts of dendrobium officinale, 3-45 parts of lotus plumule, 1-30 parts of honewort and 2-15 parts of prepared rehmannia roots. The composition disclosed by the invention can be prepared into a tablet, a capsule, extract or oral liquid according to a carrier. The traditional Chinese medicine composition has the beneficial effect of improving immunity, replenishing blood, stopping bleeding, nourishing dryness and moisturizing dryness, nourishing the skin, strengthening the spleen and stomach, lowering the blood sugar, nourishing the stomach, protecting the liver, inhibiting tumors, nourishing yin and eyes, strengthening the heart, lowering pressure, nourishing qi, soothing the nerves, soothing the liver, resolving depression and preventing radiation, is easy to take, remarkable in curative effect, gentle in effect, free of toxic and side effect, simple in preparation process, and is an ideal drug for improving the immunity, building the body and nourishing the skin.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition to raising human immunity, building body, nourishing skin Synergistic and preparation method thereof.
Background technology
Along with socioeconomic development, the raising day by day of people's living standard, the degree of concern of people to health increases gradually.At present, the health of people is subject to many outside threats, as air pollution, improper diet, operating pressure etc., very easily makes people be in the state of subhealth state, therefore improves autoimmunity, and the ability strengthening the various unfavorable health factor of antagonism is most important.
Health product in the market for enhancing human body immunity power are of a great variety, but action effect is uneven.
Summary of the invention
Object of the present invention is exactly to solve the problem, and provides a kind of Chinese medicine composition and preparation method thereof, and it has improves immunity, strengthens the spleen and stomach, nourishing the stomach hepatoprotective, nourishes the advantage such as skin.
To achieve these goals, the present invention adopts following technical scheme:
A kind of Chinese medicine composition, by weight, 5 ~ 60 parts, Colla Corii Asini, Herba Dendrobii 2 ~ 30 parts, Plumula Nelumbinis 3 ~ 45 parts, Radix Bupleuri 1 ~ 30 part, Radix Rehmanniae Preparata 2 ~ 15 parts, each composition, by synergistic function, improves body immunity to raw material.
Preferably, a kind of Chinese medicine composition, by weight, 15 ~ 50 parts, Colla Corii Asini, Herba Dendrobii 10 ~ 25 parts, Plumula Nelumbinis 10 ~ 40 parts, Radix Bupleuri 5 ~ 25 parts, Radix Rehmanniae Preparata 3 ~ 12 parts, each composition, by synergistic function, improves body immunity to raw material.
More preferred, a kind of Chinese medicine composition, by weight, 40 parts, Colla Corii Asini, Herba Dendrobii 20 parts, Plumula Nelumbinis 25 parts, Radix Bupleuri 15 parts, Radix Rehmanniae Preparata 5 parts, each composition, by synergistic function, improves body immunity to raw material.
A method for preparing tablet thereof for Chinese medicine composition, weighs each raw medicinal material according to formula, pulverizes, and the ethanol with 65% is for extractant is 55 DEG C of reflux, extract, extracting solution is gone out after ethanol, cryoconcentration becomes extractum shape, dry, be crushed to 60 orders, sieves, mixes, granulates, is pressed into tablet.
A preparation method for Chinese medicinal composition capsules, weighs each raw medicinal material according to formula, soaks 60 minutes, decoct 120 minutes, after filtration, get filtrate, add water to liquid level higher than Chinese medicine height, decoct 90 minutes, filter, then merge twice filtrate, at 0.06MPa, at 65 DEG C, be evaporated to dry cream, pulverize, cross 250 mesh sieves, add the magnesium stearate of gross weight 1%, incapsulate.
A kind of preparation method of Chinese medicine composition oral liquid formulations, each raw medicinal material is weighed according to formula, mixed, decoct with water, solution after filtration, obtain extractum by concentrated for gained solution, above-mentioned extractum is dissolved in the ethanol water of 50% of 8 times of weight, is uniformly mixed, quantitative separating, obtains oral liquid formulations.
A preparation method for Chinese medicine composition oral liquid extractum, weighs each raw medicinal material according to formula, mixes, decoct with water, the solution after filtration, obtains extractum by concentrated for gained solution.
Colla Corii Asini involved in the present invention is tonifying blood and arresting bleeding, grows the dry good medicine moisturized.Clinical practice is spat blood in blood deficiency and yellow complexion, dizzy cardiopalmus, unable, the vexed insomnia of flesh flaccidity, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, phthisical cough, spit blood, the aspects such as metrorrhagia of having blood in stool have significant curative effect; Colla Corii Asini has hematosis, the nourishing of the anemia that can be used for losing blood, iron deficiency anemia, aplastic anemia and old, child, women; And to the growth promoter of children and adolescents, there is improvement result, long-term taking Colla Corii Asini, and also can skin nutrition, make the bright and clean lubricious and tool elasticity of skin.
Herba Dendrobii involved in the present invention, its role is to, and 1) nourishing YIN to lower pathogenic fire: " Chinese pharmacy dictionary " claims Herba Dendrobii to be " specially grow the gas-liquid of lung stomach, gas-liquid is rushed prosperous, and kidney water is spontaneous ", for fever of children, conjunctival congestion and swelling pain, the effect of toothache caused by fire of deficiency type; 2) immunity is improved: healthy immunity, human body can be made to resist the defence line " strongly fortified " of disease, because human body own cells has repair, such as anemofrigid cold need not be treated, within about seven days, just can play human body repair function and spontaneous recovery, immunity moderation power, recover normal immunological function, be analogous to " strengthening the body resistance " that Chinese medicine is advocated, reach the traditional theory of " supporting just except long-pending "; 3) strengthen the spleen and stomach: Herba Dendrobii is reinforcing stomach reg fluid medicine, the common drug that all on the books in Shennong's Herbal, " book on Chinese herbal medicine is new again ", appellation " medicine for enterogastritis " is treatment gastric abscess, upper abdomen goes up painful.Modern medical experiment confirms: Herba Dendrobii has good inhibitory action to pathogenic bacterium helicobacter pylori common in the spleen-stomach disease, contributes to the effect for the treatment of the Helicobacter pylori diseases such as atrophic gastritis, superficial gastritis, duodenal ulcer, 4) blood glucose is reduced: dendrobine is that islets of langerhans supplements enough nutrition, and acute activation insulin β cell, secretes a large amount of insulins, reduce blood glucose, simultaneously the receptor on active cell surface again, makes the sugar in blood enter cell smoothly and be used, solves insulin resistant problem, comprehensive elimination complication: strengthen immunity and defying age ability, comprehensive reparation blood vessel, the system pathological changes such as nerve, metabolism, immunity, eliminate the various complication such as malaise, skin pruritus, numbness of hands and feet, blurred vision, insomnia, constipation, hypertension, hyperlipidemia, coronary heart disease, 5) relieve the effect of alcohol nourishing the stomach hepatoprotective: Compendium of Material Medica is recorded, abnormal smells from the patient: sweet, flat, nontoxic, cure mainly: damaging the spleen and stomach, the eliminating impediment therapeutic method to keep the adverse QI flowing downwards, tonifying five ZANG-organs asthenia weakness and emaciation, reinforcing YIN-essence benefit essence, clothes of a specified duration, thick the intestines and stomach, herbal classic is never sufficient in mending, flat gastric qi, longue meat, by skin Xie Re Rush gas, it is weak that foot knee joint aches cold numbness, sedate is except frightened, make light of one's life by commiting suicide and prolong life, Lu QI invigorating heat extraction, control man's waist foot weak, strong sun, by musculus cutaneus migratory arthralgia, cold for a long time in bone, the kidney invigorating benefit power, power strengthening bone and muscle, warming the kidney, Fructus Alpiniae Oxyphyllae clearing heat in QI system, solar corona controls heating spontaneous perspiration, plug in carbuncle evacuation of pus, Herba Dendrobii has tonifying five ZANG-organs, thick the intestines and stomach, the function of reinforcing YIN-essence benefit essence, Herba Dendrobii contains abundant polysaccharose substance, a kind of protecting film is produced at stomach after edible, reduce ethanol to the destruction of stomach, strengthen the metabolic function of liver simultaneously, by being in harmonious proportion in body, alcoholic strength is dissolved, drunk people is allowed to recover very fast, 6) Tumor suppression: Herba Dendrobii some cell to malignant tumor such as pulmonary carcinoma, ovarian cancer and promyelocytic leukemias has killing action, there is stronger anti-tumor activity, the clinical Tumor suppression auxiliary treatment for malignant tumor, the symptom of tumor patient can be improved, alleviate the side effect of Radiotherapy chemotherapy, enhancing immunity, improves life quality, extends life span, 7) strong muscle blood fat reducing: after people enters the middle age, cloudy Tianjin starts weak, muscles and bones function is faded, Herba Dendrobii can vital essence replenishing, lubricating joint, thus reach strengthening the tendons and bones, fluent joint, strengthen antiheumatic effect, modern pharmacological research also shows: Herba Dendrobii can improve stress ability, has good resisting fatigue, resisting oxygen lack, circulation, blood vessel dilating, reduction cholesterolemia and triglyceride can be promoted, 8) life lengthening: Herba Dendrobii is classified as the panacea having " make light of one's life by commiting suicide and prolong life " and act on by Shennong's Herbal, modern pharmacology research confirms: Herba Dendrobii contains various trace elements, good health and a long life for human body have close relationship, to the anti-aging effects of human body than general medicine more extensively, more comprehensively, 9) bright eyes: Herba Dendrobii has YIN nourishing and supports object function, by the good merchantable brand of ancient Chinese medicine doctor as eye-protecting, modern pharmacology research confirms: Herba Dendrobii is to preventing and treating senile cataract and protecting juvenile's vision to have positive effect, 10) skin is nourished: after human body enters the middle age, because the cloudy liquid in body reduces day by day, thus accelerate skin aging, make it blackening or crumple, the lymphatic temperament that Herba Dendrobii contains, human body skin is had to the effect of nourishing.
Plumula Nelumbinis involved in the present invention, embryo nelumbinis taste is extremely bitter, but has significant cardiotonic, can expand peripheral blood vessel, reduce blood pressure, propose liensinine crystallization from Plumula Nelumbinis, have the effect of blood pressure lowering, through further experiment, prove that this alkaloid Hypotensive Mechanism mainly discharges histamine, peripheral blood vessel is expanded; Plumula Nelumbinis have clear away heart-fire reduce phlegm and internal heat, arresting seminal emission, stop blooding, the effect such as to quench the thirst, heart failure, shock, sexual impotence, vexed, thirsty, haematemesis, seminal emission, conjunctival congestion can be treated, the disease such as swell and ache, clearing away heart-fire, suppressing the hyperactive liver fire, lung-fire, falls in purgation of spleen excess fire, relieve summer heat relieving restlessness, promoting the production of body fluid to quench thirst, controls order redness; Semen Nelumbinis have effect of tranquilizing by nourishing the heart, and middle-aged and elderly people particularly brain worker often eats, can brain-strengthening, and memory reinforcing, increases work efficiency, and can prevent the generation of senile dementia; Plumula Nelumbinis well goes effect of heart-fire in addition, can treat aphtha of the mouth and tongue, and conduce to sleep.
Radix Bupleuri involved in the present invention, cylindrical or conico-acuminate, long 6 ~ 15cm, diameter 0.3 ~ 0.8cm.Root head expands, residual 3 ~ 15 stem foots in top or short fiber shape phyllopodium, matter is hard and tough, not frangibility, section shows sheet-like fiber, skin zone's light brown, woody part yellow-white, feeble QI is fragrant, mildly bitter flavor, its role is to, 1) treating SHAO YANG disease by mediation: for fever caused by exogenous pathogens, or heresy enters the alternate attack of chill and fever and malaria cold and heat etc. of half exterior and half interior; 2) dispersing the stagnated live-QI to relieve the stagnation of QI: for stagnation of QI due to depression of the liver, side of body rib distension pain, and hepatic depression and blood deficiency, menoxenia etc.; 3) ascending up spleen-Qi and Yang: for deficiency of QI in middle-JIAO, proctoptosis, uterine prolapse, gastroptosis etc. that clear sun sink; 5) invasion of the blood-chamber by heat: run into menstrual onset during women suffers from fever caused by exogenous pathogens, exopathogen imports blood room into, causes cold and heat outbreak.
Radix Rehmanniae Preparata involved in the present invention, has another name called Radix Rehmanniae Preparata.For scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa(Gdertn) Iibosch.ex Fisch.et Mey.) tuber form through Processing methods, usually with wine, Fructus Amomi, Pericarpium Citri Reticulatae for adjuvant is through repeatedly steaming solarization, glossy to inside and outside darkish complexion, quality softness is sticky.After the process of preparing Chinese medicine, the property of medicine turns tepor by being slightly cold, and tonification strengthens, " herbal classic is met former ": " Radix Rehmanniae Preparata, false firepower steams and shines, and it is sweet for turning a hardship, is the yang aspect of yin, therefore vigour in energy the kidney invigorating." generation research, the Dihuang polysaccharide contained by Radix Rehmanniae Preparata has obvious immune antitumor activity, also have significant heart tonifying, diuresis, protect the liver, blood sugar lowering, anti-proliferate, exudation, antiinflammatory, antifungal, the effect such as anti-radiation.
In the present invention " Synergistic ", after can be understood as the combination of several medical material, its drug effect is relative to more obvious when being used alone, and carefree more lasting, compositions produces beyond thought effect in new control or healthcare field.
In component in the present invention, Colla Corii Asini nourishing blood hemostasis, grow dryly to moisturize, nourishes rough skin, Herba Dendrobii can improve immunity, strengthen the spleen and stomach, reduce blood glucose, nourishing the stomach hepatoprotective, Tumor suppression, YIN nourishing support order, the blood pressure lowering of Plumula Nelumbinis heart tonifying, foster the spirit of nobility and calm the nerves, Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI, Radix Rehmanniae Preparata immunity tumor suppression, radioprotective.
Compositions of the present invention can be prepared into tablet, capsule, extractum or oral liquid according to carrier, and used carrier can determine for the those of ordinary skill of pharmaceutical field.
Beneficial effect of the present invention: Chinese medicine composition of the present invention have improve that immunity, tonifying blood and arresting bleeding, taste are dryly moisturized, nourishes rough skin, strengthen the spleen and stomach, reduce blood glucose, nourishing the stomach hepatoprotective, Tumor suppression, YIN nourishing support order, heart tonifying blood pressure lowering, foster the spirit of nobility calm the nerves, dispersing the stagnated live-QI to relieve the stagnation of QI, radiation-resistant effect, be easy to take, evident in efficacy, action temperature and, have no side effect, and preparation technology is simple, is the medicine of a kind of desirable raising immunity, building body, nourishing skin.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, and following embodiment does not only limit the present invention for illustration of the present invention.
Embodiment 1:
A kind of Chinese medicine composition, 5 grams, Colla Corii Asini, Herba Dendrobii 2 grams, Plumula Nelumbinis 3 grams, Radix Bupleuri 1 gram, Radix Rehmanniae Preparata 2 grams, pulverizes above-mentioned Chinese crude drug, and the ethanol with 65% is for extractant is 55 DEG C of reflux, extract, extracting solution is gone out after ethanol, cryoconcentration becomes extractum shape, dry, be crushed to 60 orders, sieves, mixes, granulates, is pressed into tablet.
Embodiment 2:
A kind of Chinese medicine composition, 60 grams, Colla Corii Asini, Herba Dendrobii 30 grams, Plumula Nelumbinis 45 grams, Radix Bupleuri 30 grams, Radix Rehmanniae Preparata 15 grams, soaks 60 minutes, decocts 120 minutes, get filtrate after filtration, add water to liquid level higher than Chinese medicine height, decoct 90 minutes, filter, then merge twice filtrate, at 0.06MPa, at 65 DEG C, be evaporated to dry cream, pulverize, cross 250 mesh sieves, add the magnesium stearate of gross weight 1%, incapsulate.
Embodiment 3:
A kind of Chinese medicine composition, 40 grams, Colla Corii Asini, Herba Dendrobii 20 grams, Plumula Nelumbinis 25 grams, Radix Bupleuri 15 grams, Radix Rehmanniae Preparata 5 grams, after mentioned component is mixed, decoct with water, the solution after filtration, obtain extractum by concentrated for gained solution, above-mentioned extractum is dissolved in the ethanol water of 50% of 8 times of weight, be uniformly mixed, quantitative separating, obtain oral liquid formulations.
Embodiment 4:
A kind of Chinese medicine composition, 20 grams, Colla Corii Asini, Herba Dendrobii 15 grams, Plumula Nelumbinis 20 grams, Radix Bupleuri 10 grams, Radix Rehmanniae Preparata 8 grams, after being mixed by mentioned component, decocts with water, the solution after filtration, obtains extractum by concentrated for gained solution.
1 the present invention is to the clinical efficacy improving immune function of human body
1.1 crowds on probation
Child, 30,6 ~ 10 years old, immunologic hypofunction, easily caught a cold, on average monthly twice and more than;
Old people, suffers from multiple chronic disease, particularly hypertension by 30;
Women, 30,25 ~ 40 years old, pachylosis, had dysmenorrhea phenomenon.
1.2 method of administration
The oral embodiment of the present invention 3, adult, each 3 grams, every day 3 times; Child, each 1 gram, every day three times.Above patient takes 60 days continuously.
1.3 observation index
Carry out routine blood test, liver routine examination, and observed and recorded: heating, sniffle, pharyngeal symptom, body temperature, picture of the tongue pulse condition.
1.4 criterion
1.4.1 efficacy of immunity criterion
Effective: body immunity significantly improves, blood pressure of old people is reduced to normal range and keeps stable, and children's cold number of times does not once even have for one month.
Effective: body immunity improves, blood pressure of old people is slightly high and keep stable, and children's cold number of times one month once.
Invalid: old people and child's symptom are not improved.
1.4.2 skin, dysmenorrhea improve criterion
Effective: skin is clearly better, dysmenorrhea phenomenon obviously alleviates.
Effective: cutaneous roughness weakens, dysmenorrhea phenomenon alleviates.
Invalid: pachylosis and dysmenorrhea symptom are not improved.
1.5 therapeutic evaluation
1.5.1 immunity therapeutic evaluation
The therapeutic evaluation of table 1 immunity
1.5.2 skin, dysmenorrhea improve therapeutic evaluation
Table 2 skin, dysmenorrhea improve therapeutic evaluation
1.5.3 blood, liver routine examination
Table 3 blood, liver routine examination
Before and after on probation, indices is all within normal range.
Claims (6)
1., to the Chinese medicine composition improving human immunity, building body, nourishing skin Synergistic, it is characterized in that, raw material is Colla Corii Asini, Herba Dendrobii, Plumula Nelumbinis, Radix Bupleuri, Radix Rehmanniae Preparata, wherein, 40 grams, Colla Corii Asini, Herba Dendrobii 20 grams, Plumula Nelumbinis 25 grams, Radix Bupleuri 15 grams, Radix Rehmanniae Preparata 5 grams.
2. a kind of Chinese medicine composition as claimed in claim 1, is characterized in that, is prepared into tablet, capsule, extractum or oral liquid according to carrier.
3. the preparation method of the tablet of Chinese medicine composition as claimed in claim 1, it is characterized in that, each raw medicinal material is weighed according to formula, pulverized, ethanol with 65% is for extractant is 55 DEG C of reflux, extract, after extracting solution removing ethanol, cryoconcentration becomes extractum shape, dry, be crushed to 60 orders, sieves, mixes, granulates, is pressed into tablet.
4. a preparation method for Chinese medicinal composition capsules as claimed in claim 1, is characterized in that, weighed by each raw medicinal material according to formula, soak 60 minutes, decoct 120 minutes, after filtration, get filtrate, add water to liquid level higher than Chinese medicine height, decoct 90 minutes, filter, then twice filtrate is merged, at 0.06MPa, at 65 DEG C, be evaporated to dry cream, pulverize, cross 250 mesh sieves, add the magnesium stearate of gross weight 1%, incapsulate.
5. the preparation method of a Chinese medicine composition oral liquid formulations as claimed in claim 1, it is characterized in that, each raw medicinal material is weighed according to formula, mixed, decoct with water, after filtration, obtain solution, obtain extractum by concentrated for gained solution, above-mentioned extractum is dissolved in the ethanol water of 50% of 8 times of weight, be uniformly mixed, quantitative separating, obtain oral liquid formulations.
6. a preparation method for Chinese medicine composition extractum as claimed in claim 1, is characterized in that, each raw medicinal material is weighed according to formula, mixed, decocts with water, after filtration solution, obtain extractum by concentrated for gained solution.
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