CN103830558B - Anti-aging composition and preparation method thereof - Google Patents
Anti-aging composition and preparation method thereof Download PDFInfo
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- CN103830558B CN103830558B CN201210487087.0A CN201210487087A CN103830558B CN 103830558 B CN103830558 B CN 103830558B CN 201210487087 A CN201210487087 A CN 201210487087A CN 103830558 B CN103830558 B CN 103830558B
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Abstract
The invention relates to an anti-aging youth-retaining pharmaceutical composition and a preparation method thereof. The anti-aging pharmaceutical composition provided by the invention is prepared from the following raw materials: ginseng, rhizoma polygonati, radix rehmanniae, radix asparagi, poria cocos and honey. The anti-aging youth-retaining pharmaceutical composition provided by the invention can be made into any common dosage form for oral administration, has the functions of nourishing the kidneys and moistening the spleen, tonifying the spleen and replenishing qi, nourishing blood and promoting fluid production and clearing lung heat and reducing fire, and can enhance the immunological functions of human bodies, maintain the beauty and keep youth and resist fatigue and aging. The pharmaceutical composition has the advantages of obvious effect, convenience in taking, good mouthfeel and no toxic or side effect.
Description
Technical field
The present invention relates to a kind of compositionss for metabolic disease and preparation method thereof, more particularly to a kind of day of defying age
Right active compound and preparation method thereof.
Background technology
With growth in the living standard, people have urgent to preventing and treating aging, life lengthening, improving vitality and quality of life
The requirement cut.Definition in medical science about aging is the universal weak of organism various functions at present, and opposing environmental injury
With the phenomenon or process for recovering the reduction of homoiostasiss ability.Chinese medicine in the development course of thousands of years, in slow down aging
Each side have been made long-term effort and have been explored, and define the theoretical and system of uniqueness, have accumulated rich experience.The aging of the traditional Chinese medical science
Theory, has " natural endowment opinion ", " opinion of lacking of proper care after one's birth " and " kidney qi loss is said ", " pathogen stop up contain say ", " internal organs void declines ",
" imbalance of YIN and YANG is said " etc..Chinese medicine pays much attention to the effect of function and energy in the understanding to aging reason, and very
Emphasize that negative and positive coordinate the significance to health.Skin is the organ most easily appeared in aging course, skin aging performance
For head and appearance：Man's hair is gradually grey, and volume upper eyelid wrinkle is existing, senile plaque etc., pachylosiies, drying, blood capillary occurs
Enlargement of pipe.Skin aging is a complicated biological phenomena, is broadly divided into two kinds of forms of naturally-aged and photoaging, bright
Really skin aging is endogenous factor and the coefficient result of extrinsic factor.Professional person's research finds that many Chinese medicines contain
There are the Multiple components such as various aminoacid, lipid, polysaccharide, pectin, vitamin, trace element, organic acid, alkaloid, saponin, have
Interior free yl is removed, enhancing body oxidation resistance improves skin microcirculation, improves collagen fibers of skin and collagen protein contains
Amount, adjusts the effect such as immunologic function.With the in-depth of China's Gerontological Research Center, this kind of medicine is increasingly subject to pay attention to.In modern times
Medicine is even more under the guidance of theory of Chinese medical science, is excavated, is screened using the research method of tradition and modern science, verifying various effective
Method and medicine, delay, due to increasing the degeneration change of age and each system of human body that causes and organ, to change its aging sign,
Extend its life-span, improve vitality.
The content of the invention
The primary and foremost purpose of the present invention is to provide a kind of with defying age, looks improving and the skin nourishing for the problem that prior art is present
Compositionss and preparation method thereof, present composition prescription are simple, medical material of the raw material for using for integration of edible and medicinal herbs, moisten with nourishing kidney
Spleen, invigorating the spleen and replenishing QI, nourishing blood to promote the production of body fluid, effect of lung heat clearing pathogenic fire reducing can strengthen immune function of human body, looks improving and the skin nourishing, resisting fatigue, health care
Always.It is the preparation method simple possible of the present invention, stable processing technique, easy to use, cheap.
To realize the purpose of the present invention, one aspect of the present invention provides a kind of compositionss with anti-senescence function, including such as
Lower raw material：Radix Ginseng, Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi, Mel, Poria.
Wherein, the weight of the composition material with anti-senescence function is：
Radix Ginseng 1 ~ 20, Rhizoma Polygonati 0.5 ~ 10, Radix Rehmanniae 0.2 ~ 10, Radix Asparagi 0.5 ~ 7, Mel 0.5 ~ 8, Poria 1 ~ 10.
Particularly, the weight of the raw material is：Radix Ginseng 5 ~ 15, Rhizoma Polygonati 3 ~ 9, Radix Rehmanniae 2.5 ~ 7, Radix Asparagi 1 ~ 6, honeybee
Honey 1 ~ 7, Poria 3 ~ 7；More preferably：Radix Ginseng 8 ~ 11, Rhizoma Polygonati 4 ~ 7, Radix Rehmanniae 2.5 ~ 5, Radix Asparagi 3 ~ 6, Mel 3 ~ 4, Poria 4
~6。
Anti-apolexis composition of the present invention selects to moisten spleen by with nourishing kidney, invigorating the spleen and replenishing QI, nourishing blood to promote the production of body fluid, the effect of lung heat clearing pathogenic fire reducing and
The Radix Ginseng of integration of edible and medicinal herbs, Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi, Mel and Poria are combined and are prepared from, and can strengthen human immunity work(
Can, looks improving and the skin nourishing, resisting fatigue are anti-aging.These integration of edible and medicinal herbs Chinese crude drugs are applied in combination so that the active component in each medical material
Synergism is produced, promotes defying age, effect of looks improving and the skin nourishing.
The present invention adopts scientific method formula, raw materials used to be integration of edible and medicinal herbs Chinese crude drug plant, wherein：
Radix Ginseng be Araliaceae herbaceos perennial, mild-natured, sweet in the mouth, slight bitter, tepor；Returns spleen, lung meridian, heart channel；With big
Invigorating primordial QI, veins takes off admittedly, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, effect of tranquilize the mind and promote the intelligence；Be mainly used in treating that impairment caused by overstrain is deficient, it is lack of appetite, tired
Idle, regurgitation tell food, stool lingering diarrhea, empty cough with asthma rush, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, women
Metrorrhagia, children's intermittent infantile convulsion and prolonged deficiency be not multiple, the disease of all qi-blood-body fluid deficiencies.
The ancient pharmacy ancient books and records with regard to Chinese medicine of China《Sheng Nong's herbal classic》Radix Ginseng is classified as top grade, say its " main tonifying five ZANG-organses,
Soothe the nerves, determine soul, stop palpitate with fear, improving eyesight, happy Fructus Alpiniae Oxyphyllae, and long term usage is made light of one's life by commiting suicide macrobiosis ".Modern pharmacology research shows,
Ginsenoside and ginseng polysaccharide significantly inhibit the synthesis of fat brown pigment in rat cerebral cortex and liver；In Radix Ginseng Rubra, maltol can be with
Interior free yl combines the peroxidization for suppressing lipid in Mouse Liver, reduces the accumulation of lipofuscin etc., shows defying age work
With.The main cause of human skin aging is poor circulation, and metabolism reduction, skin elasticity weaken.Due in Radix Ginseng
Containing various ginsenosides, aminoacid, vitamin and mineral, with the blood circulation for promoting subcutaneous capillary, increase skin
The nutrition supply of skin, prevents arteriosclerosis, adjusts the effects such as moisture of skin balance.So its energy delay skin aging, prevents skin
Skin drying and dehydrating, increases the elasticity of skin, tender so as to play protection skin gloss, prevents and reduce the effect of wrinkle of skin,
Radix Ginseng active substance also has the melanic reducing property of suppression, makes skin pure white smooth.
Rhizoma Polygonati, also known as Rhizoma Polygonati Cirrhifolii, Caput Gallus domesticuss ginseng.For liliaceous plant P. kingianum（Polygonatum kingianum
Coll.et Hemsl.）, Rhizoma Polygonati（Polygonatum sibiricum Red.）Or Polygonatum cyrtonema Hua
（Polygonatumcyrtonema Hua.）Dry rhizome.Mild-natured, sweet in the mouth, return lung, spleen, kidney channel.With nourishing kidney lung moistening, mend
Effect of spleen QI invigorating；It is mainly used in lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, and chronic cough chronic cough of YIN-deficiency of the lung and kidney etc.；Weakness of the spleen and stomach.Both mended
Spleen is cloudy, and strengthening the spleen gas；Deficiency of kidney essence obtains dizzy, soreness of the waist and knees, early whitening of beard and hair and quenches one's thirst.
Rhizoma Polygonati is conventional tonic Chinese medicine, and the effect of with spleen reinforcing lung moistening, supplementing QI and nourishing YIN, for treating, body void is weak, cardiopalmus
The diseases such as shortness of breath, dryness of the lung dry cough, tinea corporis.Research in recent years shows, Rhizoma Polygonati plant contain alkaloid, flavone, quinones, lignanoid, polysaccharide,
Steroidal saponin and trace element etc..Research worker was with polygonatum oral liquid 0.2,0.4ml/d continuous gavages mice 4 weeks（To the west of respectively
YANGSHEN KOUFUYE and water make the positive, negative control respectively）, swimming 90min after put to death, as a result the oral liquid energy significantly reduce the heart,
Liver lipid peroxide（LPO）Generate（P<0.01）, increase glutathione peroxidase activity and blood peroxide disproportionation
Enzyme（SOD）Vigor, and be in dose dependent；Compared with positive controls, polygonatum oral liquid suppresses the heart, liver LPO generative capacities
Substantially increase, also in dose dependent, show that there is anti-aging to act on for which.Also confirm that polygonatum polysaccharide is turned into antioxygen in vitro
With the composition can suppress spontaneous and induction lipid peroxidation product malonaldehyde（MDA）Generation, oxygen-derived free radicals are had straight
Scavenging action is connect, thus polygonatum polysaccharide has certain effect in antioxidation and anti-aging aspect.Ming Dynasty's name doctor's Li Shizhen (1518-1593 A.D.) exists《Book on Chinese herbal medicine
Detailed outline》In then record Rhizoma Polygonati can " mend all void, replenishing essence marrow ", can make " the five internal organs reconcile, and muscle sufficiency, bone marrow are strong, and its power doubles,
Not old for many years, color clear is turned white more black, and dedentition is more raw ".Modern study shows that the effective ingredient of Rhizoma Polygonati can strengthen heart receipts
Contracting power, increase coronary blood flow reduce blood pressure and blood glucose, improve body immunity, so as to delay the aging of body.Rhizoma Polygonati
Water-alcohol preserved material concentrated solution, can be used as cosmetic colors.There is good efficacy with beriberi medicine syrup made by Rhizoma Polygonati and bath gel.With
Hair nourishing cream, black hair suppurative mastitis, black hair scalp pomade made by Rhizoma Polygonati cooperation other drugs, can make poliosis become hair color, and have certain life
Outbreak is used.
Radix Asparagi is liliaceous plant.Also known as Radix Asparagi.It is cold in nature, sweet in the mouth, slight bitter.Return liver, lung, kidney lung meridian.Have and calm the nerves, support
The curative effects such as the heart, lung moistening, tonification, nourishing kidney, blood pressure lowering and loosening bowel to relieve constipation.With replenishing YIN and removing heat, effect of lung moistening nourishing kidney.For controlling
Fever due to yin deficiency, cough haematemesis, lung abscess, laryngopharynx swelling and pain, quench one's thirst, the disease such as constipation.It is on the books in each big classics of ancients.
There is Radix Asparagi nourishing YIN to relieve dryness, lung heat clearing to promote the production of body fluid function, cure mainly that dryness of the lung dry cough, pertussis expectorant is viscous, dry throat and mouth, dryness of the intestine just
It is secret.The nourishing YIN Chinese medicine of the conventional integration of edible and medicinal herbs of Radix Asparagi system, the nineties in 20th century, people have carried out more deep to its pharmacological action
Research.Once Radix Asparagi Aqueous extracts extend the report in silkworm life-span.Recently, someone gavages Radix Asparagi Aqueous extracts, 2 Hes to the continuous 7d of mice
4g crude drugs/kg dosage all significantly extends normobaric hypoxia time-to-live and frozen water swimming time.The continuous 30d of this two dosage is gavaged, all
The low brain and liver tissues Na of D- galactose Aging mices can be improved+, K+- atpase activity, and reduce upborne brain, liver and
Plasma lipid peroxide metabolite malonaldehyde（MDA）Content.Radix Asparagi alcohol extract 2g crude drugs/kg gavage also have anti-D- galactose cause it is little
Mus aging is acted on, and significantly improves the Na in mice aging model brain, liver plasma membrane and testis mitochondrion+, K+- ATP enzyme, brain super oxygen
Compound dismutase（SOD）With testis mitochondrion activity of glutathione peroxidase, and reduce these tissue MDA contents and mistake
Lipid oxide content, recovers mouse aging brain activities of nitric oxide synthase and nitric oxide level.Radix Asparagi nanometer formulation can be carried
The anti-D- galactose of high Radix Asparagi causes aging effect.Antioxidation is the important mechanisms of Radix Asparagi defying age and antiinflammatory.Confirm Chinese medical book
《Legendary god of farming's book on Chinese herbal medicine》Statement to Radix Asparagi " long term usage is made light of one's life by commiting suicide QI invigorating, and macrobiosis is not hungry ".Radix Asparagi preserve youthful looks foster skin, brighten moist, black palpus
The beauty functions of hair color, teeth consolidating jail tooth.Modern pharmacology even more finds that the aspartic acid contained by Radix Asparagi has non-oxidizability, can hinder
The only oxidation of unsaturated fatty acid, can nurse one's health efficiency, delay and treat the keratinization of skin, keep the soft and smooth of skin and moistening.
Fresh or dried root of the Radix Rehmanniae for scrophulariaceae rehmannia glutinosa plant, cool in nature, sweet in the mouth, hardship, enter the heart, liver and kidney channel.With clear
The effect of hot removing heat from blood, YIN nourishing and the production of body fluid promoting, it is mainly used in calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, Heat Diabetes are spitted blood, nosebleed
Blood, spot dermexanthesis.
The chemical composition of Radix Rehmanniae mainly has iridoid and its glycoside, sugar, aminoacid, organic acid, sterol, flavone and dimension
Raw element etc..Wherein, sterols mainly have cupreol, stigmasterol, micro campesterol；Flavone mainly has luteolin, mountain balsam
Flavin；Iridoid and its glycoside mainly include that catalpol, dihydro catalpol, acetylcatalpol, Herba Leonuri glycoside, aucubin, single honey are special
Power glycoside, honey spy's power glycoside, sterol glycoside, iridoid A, B, C, D, Acteoside, compound saccharic, cerebroside, chlorination iridoid
Glycoside, Rehmannioside A, B, C, Radix Rehmanniae hardship glycoside etc..
Radix Rehmanniae is the key medicine in tonification class Chinese medicine, and history is loaded in《Sheng Nong's herbal classic》, it is classified as top grade.Using Fe2+- cysteine
System induces hepatomicrosome lipid peroxidation, and TAB- fluorescence methods determine that mda content, Radix Rehmanniae water extract and ethanol extract can
The different degrees of effect with antagonism hepatomicrosome lipid peroxidation, points out this to be probably Radix Rehmanniae tonification, Antiageing effect mechanism
One side.Recently, the research to Radix Rehmanniae Preparata is biased toward to the research of Radix Rehmanniae anti-aging effects mechanism, Radix Rehmanniae Preparata has reduces little
Mus brain mitochondria monoamine oxidase, MAO（MAO）The effect of activity, can also significantly improve the exhausted mining areas brain group of galactose induction
Knit middle nitricoxide synthase（NOS）And superoxide dismutase（SOD）Activity, make nitric oxide（NO）Content increases, so as to
Play the effect of slow down aging.The beautification function of Radix Rehmanniae essentially consists in profit skin, bright knowledge, black beard and hair,《Repair true secret formula》Think
Radix Rehmanniae " takes one hundred days face such as Flos persicae, take 3 years and make us living forever and never die ".
Poria, is commonly called as Poria, Song Ling, Poria, and to colonize in the fungi plant on pinaster root, as Rhizoma Dioscoreae esculentae, crust is black for shape
Brown, the inside white or pink.Dry sclerotia of its protozoa for On Polyporaceae Poria, multiparasitization is in Pinus massoniana Lamb or red
The root of pine.It is mild-natured, sweet in the mouth, light, enter the heart, lung, spleen channel.With eliminating dampness and diuresises, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control
Dysuria, oedema turgor, phlegm retention cough with dyspnea, vomiting, malignant histocytosis are had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful to wait disease.The diuretic of Poria,
Reached by strong activating the spleen pulmonary function, it is different from the Chinese medicine of other direct diuretic.Linggui zhugan decoction, decoction of four noble drugs, four Siberian cockleburs
Soup etc. is the conventional prescription for having Poria compatibility.
Poria main component is β-pachyman（Account for dry weight 93%）With triterpenoid compound Pachymic acid, pachymic acid,
3 beta-hydroxy Pilus Caprae seu Oviss steroid trienic acids.Additionally, still gummy, chitin, protein, fat, sterol, lecithin, histidine, choline
With lithium salts etc..Ancient times, Poria made pancake by imperial palace, it is believed that often to eat can salubrity be healthy and strong, life prolonging.Research worker is by Poria water
Extract and hippocampus in neonatal rats neurocyte primary cell preincubate 24h, then by cell and sodium azide incubation culture, and are not carried out
Find after preincubate group, Poria group substantially can resist the ability of the neurocyte mitochondrion reduction MTT that sodium azide causes and
Micro-tubular structure is disorderly, maintains the function and micro-tubular structure, delaying senility of cell mitochondrial, has preventing and treating neurodegenerative diseases as always
Year property is dull-witted, the effect of vascular dementia and parkinson etc..Someone adopts 4 groups of old rats, daily Indian bread polysaccharide formulation
Gastric infusion.Determine various enzyme-monoamine oxidase, MAO of enzyme related to aging, aging metabolite and removing ageing products in serum
（MAO）, malonaldehyde（MDA）And superoxide dismutase（T-SOD and Cu-SOD）Content.As a result show, pachyman administration
, compared with aged controls group, in increasing serum in various degree, T-SOD and Cu-SOD is active for group, reduces MDA contents, with anti-
Cold, resisting fatigue and anti-aging effects.Modern medicine study data shows that Poria can not only significantly improve the immunologic function of human body,
And HbO2 Oxyhemoglobins discharge more oxygen, providing organization's cell in can making blood capillary（Including skin, mucosa, hair etc.）
Enough oxygen, delaying cell aging make cell rapid regeneration, skin care increase elasticity and gloss, strengthen the youth so as to play
Vigor and beautification function.
Mel is a kind of daily health products, and the nectar that to be insecticide Apiss adopt from the spending of flowering plant is brewed in Nidus Vespae
Honey.Mel is a kind of nutritious natural nourishing food, is also one of the most frequently used tonic.According to analysis, containing with people
Various organic acid such as the close plurality of inorganic salt of body serum-concentration and vitamin, ferrum, calcium, copper, manganese, potassium, phosphorus and beneficial human body are strong
The trace element of health, and Fructose, glucose, amylase, oxidase, reductase etc., with nourishing, moisturize, detoxify, whitening is supported
The effect of face, loosening bowel to relieve constipation.Mel sweet in the mouth；It is mild-natured；Enter spleen；Stomach；Lung；Large intestine channel；With harmonizing the spleen and stomach；Relieving spasm to stop pain；Lung moistening
Cough-relieving；Loosening bowel to relieve constipation；Skin moistening granulation promoting；Removing toxic substances.The empty pain of main gastral cavity abdomen；Xeropulmonary cough；Dry constipation of intestines；Conjunctival congestion；Aphtha；Ulcer being unable to heal；
Rubella itch；Burn due to hot liquid or fire；Brothers（Army's skin）The effect split.
Chinese medicine thinks, Mel have strengthen the spleen and stomach, the function of nourishing the lung to arrest cough, loosening bowel to relieve constipation.Modern study shows, Mel
In containing multiple nutritional components such as abundant saccharide, protein, aminoacid, vitamin and mineral, with very strong medical treatment
Health-care effect.Research of all times finds that Mel is outstanding for the effect of skin-nourishing health care.Every Jing often drinks Mel
Person, its skin quality gradually become fine and smooth whitening, soft and moist high resilience.In consideration of it, increasing skin care item are all added now
Honey component, is allowed to directly act on skin, preferably plays the effect of its care skin.
Another aspect of the present invention provides a kind of preparation method of the above-mentioned compositionss with anti-senescence function, including following step
Suddenly：
1）Crude drug Radix Ginseng, Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi, Mel, Poria are weighed, wherein Radix Ginseng, Poria are crushed respectively,
Prepared Radix Ginseng powder, Poria powder, it is standby；
2）Crude drug Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi are mixed after Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi mixed material, are added water,
Heating extraction is carried out to mixed material, extracting solution is collected；
3）Concentration is carried out to extracting solution, the concentrated extract of Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi is made；
4）Crude drug Poria powder, Radix Ginseng powder and Mel are added to into concentrated extract mixing, are dried, are obtained final product.
Another aspect of the invention provides a kind of preparation method of the above-mentioned compositionss with anti-senescence function, including following step
Suddenly：
1）Crude drug Radix Ginseng, Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi, Mel, Poria are weighed, wherein Radix Ginseng, Poria are crushed respectively,
Prepared Radix Ginseng powder, Poria powder, it is standby；
2）Crude drug Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi are mixed after Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi mixed material, are added water,
Heating extraction is carried out to mixed material, extracting solution is collected；
3）Concentration is carried out to extracting solution, the concentrated extract of Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi is made；
4）Crude drug Poria powder and Mel are added to into concentrated extract mixing, crushed after being dried is obtained dry extract powder；
5）Radix Ginseng powder is added in dry extract powder, mix homogeneously is obtained final product.
Wherein, step 1）Described in Radix Ginseng powder, Poria powder granularity be 60-180 mesh.
Wherein, step 2）Described in heating extraction include the step of order below is carried out：
A）Water is added in mixed material, is soaked, is then carried out first time heating extraction, wherein, the weight of the water of addition
Ratio with the gross weight of mixed material is 6-12：1, heating-up temperature is 40-100 DEG C, and the heating extraction time is 1-4 hours；
B）First time extracting solution is filtered, filtrate is collected；
C）Water is added in filtering residue, second heating extraction is carried out, wherein, the weight of the water of addition and the weight of mixture
Ratio be 6-12：1, heating-up temperature is 40-100 DEG C, and the heating extraction time is 1-4 hours；
D）Filter, the filtrate filtered twice is merged.
Particularly, step A）Described in soak time be 20-90min, preferably 30-60min；The weight of the water of addition with
The ratio of the gross weight of mixed material is preferably 8-10：1；Heating extraction temperature is preferably 60-100 DEG C, more preferably 80-
100℃；The heating extraction time is preferably 2-3h；Step C）The weight of the water of middle addition is 8-10 with the weight ratio of mixture：
1；Heating extraction temperature is preferably 60-100 DEG C, more preferably 80-100 DEG C；The heating extraction time is preferably 2-3h.
Particularly, also including step E）：Water is added in filtering residue after filtering to second heating extraction, third time is carried out and is added
Heat is extracted, wherein, the weight of the water of addition is 6-12 with the weight ratio of mixture：1, heating-up temperature is 40-100 DEG C, heating
Extraction time is 1-4 hours；Then filter, filtrate merges.
Especially, step E）The weight of the water of middle addition is preferably 8-10 with the ratio of the gross weight of mixed material：1；Heating
Extracting temperature is preferably 60-100 DEG C, more preferably 80-100 DEG C；The heating extraction time is preferably 2-3h.
Wherein, step 3）Described in temperature is controlled during concentration for 40-100 DEG C.
Particularly, the concentration is that extracting solution is carried out evacuation concentrating under reduced pressure, and thickening temperature is 40-100 DEG C, excellent
Elect 60-100 DEG C as, relative pressure during concentration is -0.05 ~ -0.095MPa, preferably -0.05 ~ -0.07MPa.
Particularly, the concentration is that normal pressure concentration is carried out to extracting solution, and thickening temperature is 40-100 DEG C, preferably
60-100 DEG C, relative pressure during concentration is 0Mpa.
Wherein, step 3）Described in concentrated extract relative density be 1.1-1.7, preferably 1.1-1.3, further preferably
For 1.2-1.3；Step 4）Described in baking temperature be 40-75 DEG C, preferably 50-70 DEG C；The granularity of the powder is 80-180
Mesh, preferably 100-180 mesh.
Another aspect of the invention provides a kind of by any of the above-described compositionss and pharmaceuticss with anti-senescence function
Defying age, the pharmaceutical preparation of enhancing immunity made by acceptable auxiliary material combination.
Wherein, the compositionss with anti-senescence function of the invention can with acceptable adjuvant on pharmaceuticss by tradition or
Modern production process makes clinical acceptable peroral dosage form.As powder, medicinal tea, granule, capsule, tablet, concentrated pill,
Drop pill, soft extract etc..Excipient substance used can be starch, dextrin, magnesium stearate, essence, micropowder silica gel, Pulvis Talci, sugarcane
It is sugar, Microcrystalline Cellulose, Sodium Hydroxymethyl Stalcses, stevioside, glucose, Lactose, poloxamer, any one in PEG2000 ~ 6000
Plant or various.Long-term prescription is clinically needed, solid preparation storage is made conveniently, patient takes facility, also more adapting to market needs
Ask.Preferred dosage form is capsule, granule, tablet.
The anti-senescence function compositionss of the present invention have the advantage that：
1st, the anti-ageing compositionss prescription compatibility science of preserving youthful looks of the present invention, formula are unique, and effect is definite, and safe, quality can
Control；
2nd, the anti-ageing compositionss of preserving youthful looks of the present invention have a nourishing kidney profit spleen, invigorating the spleen and replenishing QI, nourishing blood to promote the production of body fluid, effect of lung heat clearing pathogenic fire reducing,
Active component in each medical material produces synergism, can strengthen immune function of human body, and looks improving and the skin nourishing, resisting fatigue are anti-aging；
3rd, the present invention it is anti-ageing preserve youthful looks combination of Chinese medicine material be integration of edible and medicinal herbs Chinese crude drug, can long-term taking, have no side effect,
Prepare it is anti-ageing preserve youthful looks medicine or health product defying age and looks improving and the skin nourishing effect it is obvious；
4th, the preparation method of the anti-ageing compositionss of preserving youthful looks of the present invention is simple, and process conditions are gentle, and with low cost, expense is low.
Specific embodiment
The beneficial effect of medicine of the present invention is further described below by specific embodiment, these test example bags
The anti-ageing granule of preserving youthful looks of combination of the invention is included（Embodiment 1）, anti-ageing capsule of preserving youthful looks（Embodiment 2）Pharmacodynamics test.These realities
It is only exemplary to apply example, does not constitute any restriction to the scope of the present invention.It will be understood by those skilled in the art that
The details of technical solution of the present invention and form can be modified or replaced under formula thinking, purposes scope without departing from the present invention
Change, but these modifications and replacement are each fallen within protection scope of the present invention.
The impact of test example 1 anti-ageing preserve youthful looks Granules on Mouse activity of SOD in serum and MDA, NO level
1st, test material：：
Kunming mouse：Male and female half and half, 20 ± 5g of body weight are provided by dimension tonneau China animal experimental center, quality certification numbering：
SCXK (capital) 2009-003.
Anti-ageing granule of preserving youthful looks：2g/ bags（Per bag of 10g containing crude drug）；Positive drug：Vitamin E（East Sea pharmaceutical factory）.
2nd, test method：
Cleaning grade health Kunming mouse 60 is taken, male and female half and half are randomly divided into 6 groups, 10 per group, i.e. blank
Group, model control group, positive drug group, defying age granule high dose group（200mg/kg）, middle dose group（100mg/kg）, low dose
Amount group（50mg/kg）.In addition to 0.9% sodium chloride injection of naive mice dorsal sc injection equal-volume, remaining each group uses D-
Galactose presses 120mg/kg dorsal sc injections, once a day, continuous 30 days, prepares subacute aging model.From modeling the 21st
Its beginning is administered as follows respectively, once a day, continuous 10 days.Positive drug group mouse gavaging 25mg/kg Vitamin E；
The mice of high, medium and low dosage group gavages 200 respectively, 100, the anti-ageing granules of preserving youthful looks of 50mg/kg；Blank control group and model comparison
Group mice gavages 0.9% sodium chloride injection of equal-volume respectively.30min after last dose, takes blood from mouse orbit, centrifugation
（3000r/min, 10min) take serum.Try by serum superoxide dismutaseses (SOD), malonaldehyde (MDA) and nitric oxide (NO)
Agent box description determines activity of SOD in serum and MDA, NO level.Result of the test is shown in Table 1.
1 mice serum SOD of table activity and MDA, NO level compare
Note：Compare with blank control group,*P ＜ 001, are compared with model control group,**P ＜ 001
Compare with blank control group, model control group mice serum SOD activity is reduced, and MDA, NO level is raised, and difference is equal
Statistically significant (P<0.01).High dose group, middle dose group, low dose group mice serum SOD activity are aobvious compared with model control group
Write and improve, serum MDA, NO levels are remarkably decreased to group compared with model, the statistically significant (P of difference<0.01).High, medium and low dose
Amount group mice serum SOD activity and MDA, NO level are compared with blank control group and positive drug control group, and difference is without statistics
Learn meaning (P>0.05).Result of the test shows：It is anti-ageing preserve youthful looks granule can enhancing body remove the ability of free radical, reduce tissue thin
The degree of cellular damage, with certain anti-aging effects；Its anti-aging effects intensity is close with Vitamin E.
The impact of the anti-ageing Granules on Mouse GSH-Px in serum activity of preserving youthful looks of test example 2
1st, test material：
Kunming mouse：Male and female half and half, 20 ± 5g of body weight are provided by dimension tonneau China animal experimental center, quality certification numbering：
SCXK (capital) 2009-003.
Anti-ageing granule of preserving youthful looks, 2g/ bags（Per bag of 10g containing crude drug）.
2nd, test method：
Kunming mouse 50 is taken, male and female half and half are randomly divided into 5 groups, 10 per group, respectively blank control group, model
Matched group, anti-ageing granule low dose group (50mg/kg) of preserving youthful looks, middle dose group (100mg/kg), heavy dose of group (200mg/kg).Remove
Outside 0.9% sodium chloride injection of blank mouse back subcutaneous injection equal-volume, remaining each group presses 125mg/ using D- galactose
Kg dorsal sc injections, every morning once, continuous 30 days, prepare subacute aging model.While model is prepared, daily
Afternoon administration group gastric infusion once, successive administration 42 days.The mice of high, medium and low dosage group gavages 200 respectively, 100,50mg/
The anti-ageing granules of preserving youthful looks of kg；Blank control group, model control group such as gavage every afternoon at the capacity normal saline.After last dose
30min, sacrifice, takes blood, prepares serum, determines the activity of GSH-Px in serum.Result of the test is shown in Table 2.
Anti-ageing impact of the granule to each group mice serum GSH-Px activity of preserving youthful looks of table 2
Note：Compare with model control group.**p<001,*P<005。
Anti-ageing particle delivery group of preserving youthful looks can improve the activity of GSH-Px in mouse aging serum, and difference has significance (P
<0.01). the anti-ageing granule of preserving youthful looks of prompting can improve the activity of antioxidant enzyme.Accelerate the decomposition of free radical, with good enhancing
The effect of antioxidant ability of organism.
Anti-ageing impact of the granule to hypoimmunity mice immune organ quality of preserving youthful looks of test example 3
1st, test material：
Kunming mouse：Male and female half and half, 20 ± 5g of body weight are provided by dimension tonneau China animal experimental center, quality certification numbering：
SCXK (capital) 2009-003.
Anti-ageing granule of preserving youthful looks, 2g/ bags（Per bag of 10g containing crude drug）；Prednisolone acetate, Guangdong Huanan Pharmaceutical Co., Ltd.
2nd, test method：
Cleaning grade health Kunming mouse 60 is taken, 5 groups are randomly divided into, 12 per group, respectively blank control group, model
Matched group, anti-ageing granule high dose group of preserving youthful looks（200mg/kg）, middle dose group（100mg/kg）, low dose group (50mg/kg).Remove
Outside blank control group, other each group mice morning gavages give the prednisolone acetate of 40mg/kg, and afternoon, gavage gave corresponding dosage
Anti-ageing granule of preserving youthful looks；Model group mice morning gavage gives the prednisolone acetate of 40mg/kg, afternoon gavage give it is isometric
Distilled water, successive administration 12 days.After last dose 1 hour, mice de- cervical vertebra is put to death, is claimed weight, is taken spleen and thymus, use
Electronic balance claims quality, calculates Thymus and spleen index (W)：WSpleen=MSpleen/MBody weight, WThymus=MThymus/MBody weight.Result of the test is shown in Table 3.
The anti-ageing granule of preserving youthful looks of table 3 is to hypoimmunity mice index and spleen index, the impact of thymus index
Note：Compare with blank group matched group,*p<001.Compare with model control group,***p<001,**P<005。
Experimental result shows：Compare with blank control group, the index and spleen index of model group mice, thymus index are significantly reduced
(P<0.01), show that prednisolone acetate causes immunodeficiency models success.The high, medium and low dosage group of anti-ageing granule of preserving youthful looks can be significantly
The index and spleen index of hypoimmunity mice is improved, is compared with model group, difference has significant (P<0.01).Anti-ageing granule of preserving youthful looks
Low, middle dose group can significantly improve the thymus index (P of hypoimmunity mice<0.05 or P<0.01).Test result indicate that, in vinegar
Under conditions of sour prednisone causes mice to form immunosuppressant, anti-ageing granule of preserving youthful looks can increase mouse thymus and index and spleen index.
Anti-ageing impact of the granule to normal mouse red blood cell sum of preserving youthful looks of test example 4
1st, test material：
Kunming mouse：Male and female half and half, body weight 20-24g are provided by dimension tonneau China animal experimental center, quality certification numbering：
SCXK (capital) 2009-003.
Anti-ageing granule of preserving youthful looks, 2g/ bags（Per bag of 10g containing crude drug）.Cyclophosphamide（Hengrui Medicine Co., Ltd., Jiangsu Prov.）.
2nd, test method：
30 healthy mices of random selection, are randomly divided into 3 groups.10 per group, respectively blank group, immunosuppressant group and anti-
Decline particle group of preserving youthful looks.Immunosuppressant group and anti-ageing particle group of preserving youthful looks are respectively at the 1st, 3, that 5 day morning gave mouse peritoneal injection is same
Deng dose Cyclophosphamide (25mg/kg, before administration during fasting 12) 1 time；Anti-ageing particle group afternoon of preserving youthful looks oral anti-ageing granule of preserving youthful looks
(100mg/kg)；Immunosuppressant group gives the distilled water of same volume afternoon.Carry out orbital vein within the 1st, 2,3,4 weeks after administration
Clump blood sampling, carries out red blood cell count(RBC).Result of the test is shown in Table 4.
Impact of the anti-ageing granule of preserving youthful looks of table 4 to immunosuppressed mice Erythrocytes (×109)
Note：Compare with blank group*p<005,**p<001；Compare Δ p with suppression group<005
The red blood cell count(RBC) result of the test of And Utilization of CTX-Immunosuppressed-mice is understood, is compared with immunosuppressant group, anti-ageing
The red blood cell count(RBC) of particle group of preserving youthful looks 4th week has clear improvement（p<0.05）, illustrate the immunity suppression of anti-ageing Granules on Mouse of preserving youthful looks
It is formed with obvious resistant function.
The impact of the anti-ageing Granules on Mouse swimming time of preserving youthful looks of test example 5
1st, test material：
Kunming mouse：Male and female half and half, 20 ~ 28g of body weight are provided by dimension tonneau China animal experimental center, quality certification numbering：
SCXK (capital) 2009-003；
Anti-ageing granule of preserving youthful looks, 2g/ bags（Per bag of 10g containing crude drug）；Positive drug：QINGCHUN BAO（0.5g/ grains, honest youth are protected
Pharmaceutcal corporation, Ltd）.
2nd, test method：
Kunming mouse 50 is taken, 20 ~ 28g of body weight, male and female half and half are randomly divided into five groups, 10 per group, it is respectively blank
Matched group, positive controls, anti-ageing granule low dose group (100mg/kg) of preserving youthful looks, middle dose group (200mg/kg), heavy dose of group
(300mg/kg).It is anti-ageing preserve youthful looks particle delivery group mice respectively gavage give the anti-ageing granule 100mg/kg that preserves youthful looks, 200mg/kg,
300mg/kg；Positive controls mice gives 200mg/kg QINGCHUN BAO；Blank control group such as gives at the normal saline of capacity, continuously
Gavage 7 days.After last dose, 1h is put into depth of water 25cm by mouse tail system with the load of body weight 10%, 30 ± 1 DEG C of water temperature
In swimming cylinder, the swimming time of mice is recorded.Result of the test is shown in Table 5.
The impact of the anti-ageing Granules on Mouse swimming time of preserving youthful looks of table 5
Note：Compare with blank group**p<001；Compare Δ p with positive controls<005, Δ Δ p<001.
Compare with blank control group, when the basic, normal, high dosage group of anti-ageing granule of preserving youthful looks is remarkably improved mice swimming survival
Between（p<0.01）, illustrate the antifatigue effect that anti-ageing granule of preserving youthful looks has.
The impact of the anti-ageing Granules on Mouse the survival time under hypoxic condition of preserving youthful looks of test example 6
1st, test material：
Kunming mouse：Male and female half and half, 20 ~ 28g of body weight are provided by dimension tonneau China animal experimental center, quality certification numbering：
SCXK (capital) 2009-003；
Anti-ageing granule of preserving youthful looks, 2g/ bags（Per bag of 10g containing crude drug）；Positive drug：Three Le starch oral liquid（The magnificent pharmacy in Sichuan
Company limited）.
Test method：
Healthy Kunming mouse 50 is taken, 20 ~ 28g of body weight, male and female half and half are randomly divided into five groups, 10 per group, respectively
Blank control group, positive controls, anti-ageing granule low dose group (100mg/kg) of preserving youthful looks, middle dose group (200mg/kg), big agent
Amount group (300mg/kg).It is anti-ageing preserve youthful looks particle delivery group mice respectively gavage give the anti-ageing granule 100mg/kg that preserves youthful looks, 200mg,
300mg/kg；Positive controls mice gives the three Le slurry oral liquid of 200mg/kg；Blank control group such as gives at the physiology of capacity
Saline, continuous gavage 7 days.After last dose, 1h is put into mice equipped with 10g, in the closed wide mouthed bottles of 250mL of sodica calx, note
The time-to-live of record mice.Result of the test is shown in Table 6.
The impact of the anti-ageing Granules on Mouse the survival time under hypoxic condition of preserving youthful looks of table 6
Note：Compare with blank group*p<005,**p<001；Compare Δ p with positive controls<005.
Compare with blank control group, anti-ageing granule low dose group of preserving youthful looks can improve anoxia in mice time-to-live (P<0.05),
The middle and high dosage group of anti-ageing granule of preserving youthful looks is remarkably improved anoxia in mice time-to-live (P<0.01), illustrate anti-ageing granule tool of preserving youthful looks
There is antifatigue effect.
Anti-ageing therapeutical effect of the capsule to chloasma of preserving youthful looks of test example 7
1st, physical data：
Treatment group：The anti-ageing capsule of preserving youthful looks of the present invention（0.3g/ grains, per 1.5g containing crude drug）See through 166 triers altogether
Examine the effect for understanding functions of removing chloasma；
Matched group：Using positive control drug：BAZHEN YIMU JIAONANG（0.28g/ grains, Sanghai Pharmaceutical Factory) to 83
Trier's observation understands the effect of functions of removing chloasma,
Trier is women, age 18-60 year, the visible chloasma of Head And Face perusal, without symptoms such as any sufferings.Adopt
It is compared with medicine cross-reference mode of the present invention itself is taken.
2nd, instructions of taking：
Treatment group：Oral 2 times daily, 2 every time, early, evening takes, and is within 2 months 1 course for the treatment of.
Positive controls：3 times a day, 3 every time, early, middle and late to take, and is within 2 months 1 course for the treatment of.
Anemia of pregnant woman disables, and experimenter cuts out other health product during testing and uses other whitening and speckle dispelling classes to make up
Product.
3rd, treat standard：
The clinical diagnosises of the chloasma formulated with reference to Dermatology Professional Committee of CAIM (Chinese Association Of Integrative Medicine) pigment group
With curative effect determinate standard,《Dermatological》、《Practical Surgery of Chinese Medicine》Draft.
1st, the change of mottle size：With length and width of the same chloasma of tape measure before and after tested, color is calculated
Speckle area；
2nd, the change of mottle shade：According to Institute of Geography, Academia Sinica's development and design, Mapping Press 1992
What year published《Practical standard colour atla》（The first edition）In brown（Y+M+BK is yellow+pinkish red+black folded color）Colour atla is chloasma
The criterion of shade：I degree（15、20、5）, II degree（30、40、10）, III degree（40、60、15）.
4th, freckle effect judges
1st, it is basic to cure：Chloasma disappears substantially；
2nd, it is effective：Chloasma color substantially shoals, and area is reduced>1/3, do not produce new chloasma；
3rd, take a turn for the better：Chloasma lighter, area reduce≤1/3, do not produce new chloasma；
4th, it is invalid：Chloasma color and area are without significant change.
5th, result of the test
Experimental result is as shown in table 7.
Therapeutical effect of the table 7 to chloasma
Note：Compare with matched group*p<001。
The curative effect for the treatment of group is apparently higher than matched group, and basic cure rate and obvious effective rate are also apparently higher than matched group；Control
Treatment group patient feels that spirit takes a turn for the better while facial colour spot disappears, energetic, sleep improvement, some patientss menoxenia,
The gynaecopathias such as dysmenorrhea also obtain effective；Two groups of cases are showed no untoward reaction during treating.
Anti-ageing opsonic action of the capsule to sub-health state of preserving youthful looks of test example 8
1st, physical data：
Treatment group：The anti-ageing capsule of preserving youthful looks of the present invention（0.3g/ grains, per 1.5g containing crude drug）See through 130 triers altogether
Examine and understand the effect for adjusting sub-health state；
Matched group：Using positive control drug：Oral oryzanol tabletses（30mg/ pieces, Sanghai Pharmaceutical Factory) to 126
Trier observes the effect that solution adjusts sub-health state.
Trier's age 18-40 year, with insomnia and dreamful sleep, fatigue and weakness, lassitude, dizzy nose heave, sensation of oppression over the chest with shortness of breath, food
It is intended to the symptoms such as depressed, susceptible to lose temper due to restlessness, spontaneous perspiration hyperhidrosis.It is compared using medicine cross-reference mode of the present invention itself is taken.
2nd, instructions of taking：
Treatment group：Oral 2 times daily, 2 every time, early, evening takes, and is within 2 months 1 course for the treatment of.
Positive controls：3 times a day, and 3 tablets once, early, middle and late to take, and is within 2 months 1 course for the treatment of.3rd, result of the test
Subhealth state clinical symptoms are tested and assessed：Insomnia and dreamful sleep, fatigue and weakness, lassitude, dizzy nose heave, sensation of oppression over the chest with shortness of breath, appetite
Depressed, susceptible to lose temper due to restlessness, spontaneous perspiration hyperhidrosis.Semiography adopts sxemiquantitative integration method.Scoring system is as follows：Person is not said automatically, mainly
Symptom remembers 5 points, and minor symptom remembers 3 points；The inquiry person of saying, cardinal symptom remember 4 points, and minor symptom remembers 2 points；Symptom cuts in and out
Person, cardinal symptom remember 3 points, and minor symptom remembers 1 point；Asymptomatic person, remembers 0 point.Result of the test is shown in Table 8.
Anti-ageing opsonic action of the capsule to sub-health state of preserving youthful looks of table 8
Note：With this group before treatment*p<001；Compare Δ p with after treatment of control group<005.
Knowable to experimental result：After treatment, clinical symptoms integration is reduced, the statistically significant (p of self-contrast before and after treatment<
0.01), anti-ageing capsule of preserving youthful looks can improve sub-health population clinical symptoms.
9 acute toxicity test of test example
NIH systems healthy mice 20 is chosen, body weight is 18-20 gram, male and female half and half.Before experiment, elder generation's fasting 12 hours, real
When testing, with the tolerant Cmax of white mice, the dose of maximum volume, by the present invention anti-ageing granule of preserving youthful looks（0.3g/ grains, often
Grain 1.5g containing crude drug）The suspension that concentration is 30% is made into, according to 15g/kg body weight gastric infusion 1 time, is observed 7 days.Experiment knot
Really：The compositionss of the present invention are not measured to mice LD50 values, 961 times equivalent to clinical dosage of the dosage, medicine of the present invention is given
The maximum tolerated dose of mice lavage administration is more than 15g/kg, shows that the medicine or functional food of the present invention is anti-without acute toxicity
Should, safety is good.
10 long term toxicity test of test example
After animal feeding is observed 1 week, the normal NIH systems healthy mice of indices 96, male and female half and half, body weight are selected
For 18-20g, 4 groups are randomly divided into, every group of animal 24, i.e., anti-ageing granule high dose group of preserving youthful looks of the invention（0.18g/kg）, middle dose
Amount group（0.36g/kg）, low dose group（0.54g/kg）And matched group.During off-test, 20 are randomly selected per group and determines every
Index, it is remaining to put to death cut open inspection.
High, medium and low dosage group dosage is respectively equivalent to pharmacodynamicss equivalent to 40 times, 80 times, 160 times of quantity
1,2,4 times of effective dose.Anti-ageing granule distillation aqueous suspension of preserving youthful looks is prepared, by 44mg/kg, 88mg/kg, 176mg/kg body
The oral gastric infusion of weight, 2 times a day, and matched group gives the starch suspension of equivalent.With the general performance before and after animal administration, body
Weight, hematology and Biochemical Indices In Serum, routine urinalysis, organ weights equipotential Testing index, and it is aided with the disease that animal respectively organizes internal organs
It is of science to check, the toxicity profile of overall merit medicine.
As a result show：Medicament capsule of the present invention changes to the weight of animals without the significance difference opposite sex, and animal growth is normal；
Every Index for examination of high, medium and low dosage group animal shows no obvious abnormalities；Histopathologic examination's result shows, three dosage
Group animal respectively organizes internal organs no abnormality seen.Show that medicine of the present invention has no that long term toxicity reacts, be safe medication.
With reference to embodiment, the present invention will be further described.
The preparation of the anti-ageing granule of preserving youthful looks of 1 present invention of embodiment
1）Prepare raw material according to following weight proportion（kg）：
Radix Ginseng 10, Rhizoma Polygonati 5, Radix Rehmanniae 2.5, Radix Asparagi 3, Mel 4, Poria 6
Wherein, it is the Poria powder of 60-100 mesh, Radix Ginseng powder Poria, Radix Ginseng to be respectively crushed into granularity, standby；
2）To be placed in Multifunctional Chinese medicine extraction pot after Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi mix homogeneously, add tap water immersion
30min, wherein the weight of the tap water for adding is 9 with the ratio of raw material gross weight：1；
3）Open multi-function extractor power supply to be heated, be heated to 100 DEG C, keep constant temperature at this temperature to extract 2 little
When after filter, obtain first time extracting solution standby；
4）Tap water is added in filtering residue, the weight of the tap water of addition is 6 with the ratio of raw material gross weight：1, heating is carried
Take, heating-up temperature is 100 DEG C, and extraction time is 2 hours, is filtrated to get second extracting solution；
5）Being placed in vacuum high energy evaporation concentrator after 2 extracting solution are merged carries out concentrating under reduced pressure, and relative density is obtained
For 1.2 extractum, wherein, the relative pressure of concentrating under reduced pressure is -0.07MPa（I.e. with an atmospheric pressure as 0, concentrating under reduced pressure is controlled
When pressure relative to an atmospheric pressure be -0.07MPa）, thickening temperature is 80 DEG C；
6）To in extractum, add Poria powder, Radix Ginseng powder and Mel, mix homogeneously that drying under reduced pressure process is carried out at 50 DEG C,
The relative pressure of drying under reduced pressure is -0.07MPa, and it is to crush after 5% to make granularity for 180 mesh composition powders to be dried to moisture content；
7）Composition powder is mixed with adjuvant dextrin, alcohol granulation, be dried, that is, anti-ageing granule of preserving youthful looks is obtained.
Wherein, heating extraction temperature is not limited to 100 DEG C, and heating-up temperature is applied to the present invention at 60-100 DEG C；Constant temperature is carried
The time of taking is not limited to 2 hours, and extraction time is applied to the present invention in 1-4 hours.
The preparation of the anti-ageing capsule of preserving youthful looks of 2 present invention of embodiment
1）Prepare raw material according to following weight proportion（kg）：
Radix Ginseng 8, Rhizoma Polygonati 4, Radix Rehmanniae 3, Radix Asparagi 4, Mel 4, Poria 4
Wherein, it is the Poria powder of 100-180 mesh, Radix Ginseng powder Poria, Radix Ginseng to be respectively crushed into granularity, standby；
2）To be placed in Multifunctional Chinese medicine extraction pot after Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi mix homogeneously, add tap water immersion
30min, wherein the weight of the tap water for adding is 8 with the ratio of raw material gross weight：1；
3）Open multi-function extractor power supply to be heated, be heated to 100 DEG C, keep constant temperature at this temperature to extract 2 little
When after filter, obtain first time extracting solution；
4）Tap water is added in filtering residue, the weight of the tap water of addition is 8 with the ratio of raw material gross weight：1, heating is carried
Take, heating-up temperature is 100 DEG C, and extraction time is 2 hours, is filtrated to get second extracting solution；
5）Being placed in vacuum high energy evaporation concentrator after 2 extracting solution are merged carries out concentrating under reduced pressure, and relative density is obtained
For 1.1 extractum, wherein, the relative degree of vacuum in concentration process is -0.07MPa, and thickening temperature is 70 DEG C；
6）Poria powder and Mel are added in extractum, drying under reduced pressure process, the phase of drying under reduced pressure are then carried out at 70 DEG C
It is -0.08MPa to pressure, drying to moisture content is crushing after 4%, and prepared granularity is the dry extract powder of 100 mesh；
7）Dry extract powder is mixed with Radix Ginseng fine powder, is loaded in capsulae vacuuses, that is, anti-ageing capsule of preserving youthful looks is obtained.
The preparation of the anti-ageing piece of preserving youthful looks of 3 present invention of embodiment
1）Prepare raw material according to following weight proportion（kg）：
Radix Ginseng 9, Rhizoma Polygonati 3, Radix Rehmanniae 3, Radix Asparagi 5, Mel 4, Poria 3
Wherein, it is the Poria powder of 120-180 mesh, Radix Ginseng powder Poria, Radix Ginseng to be respectively crushed into granularity, standby；
2）To be placed in Multifunctional Chinese medicine extraction pot after Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi mix homogeneously, add tap water immersion
50min, wherein the weight of the tap water for adding is 9 with the ratio of raw material gross weight：1；
3）Open multi-function extractor power supply to be heated, be heated to 85 DEG C, keep constant temperature at this temperature to extract 3 little
When, then filter, obtain first time extracting solution；
4）Point 2 addition tap waters, heating extraction 2 times in filtering residue, the temperature of each heating extraction is 85 DEG C, addition
The weight of tap water is 9 with the ratio of raw material gross weight：1, extraction time is 3 hours, is filtrated to get 2 extracting solution；
5）Atmospheric evaporation concentration is carried out after 3 extracting solution are merged, prepared relative density is 1.3 extractum, wherein, concentration
Relative pressure be 0MPa, thickening temperature be 100 DEG C；
6）Poria powder and Mel are added in extractum, then at 65 DEG C under carry out drying under reduced pressure process, drying under reduced pressure
Relative pressure be -0.08MPa, be dried to moisture content be 5% after crush, be obtained granularity be 100 mesh dry extract powders；
7）Dry extract powder is mixed with Radix Ginseng fine powder, adjuvant, granule is made, and is dried, it is tabletted.
The preparation of the anti-ageing tea of preserving youthful looks of 4 present invention of embodiment
1）Prepare raw material according to following weight proportion（kg）：
Radix Ginseng 10, Rhizoma Polygonati 4, Radix Rehmanniae 5, Radix Asparagi 5, Mel 4, Poria 6；
Wherein, it is the Poria powder of 80-120 mesh, Radix Ginseng powder Poria, Radix Ginseng to be respectively crushed into granularity, standby；
2）To be placed in Multifunctional Chinese medicine extraction pot after Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi mix homogeneously, add tap water immersion
40min, wherein the weight of the tap water for adding is 10 with the ratio of raw material gross weight：1；
3）Open multi-function extractor power supply to be heated, be heated to 80 DEG C, keep constant temperature at this temperature to extract 2.5 little
When, then filter, obtain first time extracting solution；
4）Point 2 addition tap waters, heating extraction 2 times in filtering residue, the temperature of each heating extraction is 80 DEG C, addition
The weight of tap water is 10 with the ratio of raw material gross weight：1, extraction time is 2.5 hours, is filtrated to get 2 extracting solution；
5）Atmospheric evaporation concentration is carried out after 3 extracting solution are merged, prepared relative density is 1.3 extractum, wherein, concentration
Relative pressure be 0MPa, thickening temperature be 100 DEG C
6）Poria powder and Mel are added in extractum, drying under reduced pressure process, the phase of drying under reduced pressure are then carried out at 55 DEG C
To pressure be -0.06MPa, be dried to moisture content be 4% after crush, be obtained granularity be 150 mesh dry extract powders；
7）Dry extract powder is mixed with Radix Ginseng fine powder, is loaded in filter paper bag, is made teabag.
The preparation of the anti-ageing concentrated pill of preserving youthful looks of 5 present invention of embodiment
1）Prepare raw material according to following weight proportion（kg）：
Radix Ginseng 11, Rhizoma Polygonati 5, Radix Rehmanniae 5, Radix Asparagi 6, Mel 3, Poria 5；
Wherein, it is the Poria powder of 100-140 mesh, Radix Ginseng powder Poria, Radix Ginseng to be respectively crushed into granularity, standby；
2）To be placed in Multifunctional Chinese medicine extraction pot after Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi mix homogeneously, add tap water immersion
60min, wherein the weight of the tap water for adding is 9 with the ratio of raw material gross weight：1；
3）Open multi-function extractor power supply to be heated, be heated to 85 DEG C, keep constant temperature at this temperature to extract 2 little
When, then filter, obtain first time extracting solution standby；
4）Point 2 addition tap waters, heating extraction 2 times in filtering residue, the temperature of each heating extraction is 85 DEG C, addition
The weight of tap water is 9 with the ratio of raw material gross weight：1, extraction time is 2 hours, is filtrated to get 2 extracting solution；
5）Being placed in vacuum high energy evaporation concentrator after 3 extracting solution are merged carries out concentrating under reduced pressure, and relative density is obtained
For 1.3 extractum, wherein, the relative degree of vacuum in concentration process is -0.06MPa, and thickening temperature is 65 DEG C；
6）Poria powder, Radix Ginseng fine powder and Mel are added in extractum, then drying under reduced pressure process is carried out at 60 DEG C, reduce pressure
Dry relative pressure is -0.07MPa, and drying to moisture content is crushing after 5%, and prepared granularity is the composition powder of 100 mesh；
7）By composition powder and appropriate water pill, 75 DEG C of dryings, with medicinal charcoal bag clothing, pack, obtain final product.
The preparation of the anti-ageing drop pill of preserving youthful looks of 6 present invention of embodiment
1）Prepare raw material according to following weight proportion（kg）：
Radix Ginseng 8, Rhizoma Polygonati 9, Radix Rehmanniae 6, Radix Asparagi 4, Mel 1, Poria 7；
Wherein, it is the Poria powder of 100-120 mesh, Radix Ginseng powder Poria, Radix Ginseng to be respectively crushed into granularity, standby；
2）To be placed in Multifunctional Chinese medicine extraction pot after Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi mix homogeneously, add tap water immersion
20min, wherein the weight of the tap water for adding is 12 with the ratio of raw material gross weight：1；
3）Open multi-function extractor power supply to be heated, be heated to 80 DEG C, keep constant temperature at this temperature to extract 1 little
When, then filter, obtain first time extracting solution standby；
4）Point 2 addition tap waters, heating extraction 2 times in filtering residue, the temperature of each heating extraction is 80 DEG C, addition
The weight of tap water is 12 with the ratio of raw material gross weight：1, extraction time is 1 hour, is filtrated to get 2 extracting solution；
5）Being placed in vacuum high energy evaporation concentrator after 3 extracting solution are merged carries out concentrating under reduced pressure, and relative density is obtained
For 1.25 extractum, wherein, the relative degree of vacuum in concentration process is -0.06MPa, and thickening temperature is 60 DEG C；
6）Poria powder and Mel are added in extractum, drying under reduced pressure process, the phase of drying under reduced pressure are then carried out at 60 DEG C
It is -0.07MPa to pressure, drying to moisture content is crushing after 5%, and prepared granularity is the dry extract powder of 120 mesh；
8）Dry extract powder is mixed with Radix Ginseng fine powder, the poloxamer F68 and PEG6000 of molten condition, mixing is added
After uniform, medicinal liquid be put in insulation fluid reservoir, the mixture of thawing is added dropwise under 80 DEG C of insulations the dimethicone of cooling
In, condensation cured pelletization, after taking-up is drained, sucks remaining dimethicone with filter paper, packs, obtains final product.
The preparation of the anti-ageing soft extract of preserving youthful looks of 7 present invention of embodiment
1）Prepare raw material according to following weight proportion（kg）：
Radix Ginseng 15, Rhizoma Polygonati 7, Radix Rehmanniae 7, Radix Asparagi 3, Mel 7, Poria 3；
Wherein, it is the Poria powder of 80-100 mesh, Radix Ginseng powder Poria, Radix Ginseng to be respectively crushed into granularity, standby；
2）To be placed in Multifunctional Chinese medicine extraction pot after Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi mix homogeneously, add tap water immersion
90min, wherein the weight of the tap water for adding is 6 with the ratio of raw material gross weight：1；
3）Open multi-function extractor power supply to be heated, be heated to 60 DEG C, keep constant temperature at this temperature to extract 4 little
When, then filter, obtain first time extracting solution standby；
4）Point 2 addition tap waters, heating extraction 2 times in filtering residue, the temperature of each heating extraction is 60 DEG C, addition
The weight of tap water is 8 with the ratio of raw material gross weight：1, extraction time is 4 hours, is filtrated to get 2 extracting solution；
5）Being placed in vacuum high energy evaporation concentrator after 3 extracting solution are merged carries out concentrating under reduced pressure, and relative density is obtained
For 1.2 extractum, wherein, the relative degree of vacuum in concentration process is -0.05MPa, and thickening temperature is 65 DEG C；
6）Poria powder and Mel being added in extractum, then constant pressure and dry being carried out at 60 DEG C, it is 6% to be dried to moisture content
After crush, prepared granularity is the dry extract powder of 80 mesh；
8）Dry extract powder is mixed with Radix Ginseng fine powder, add sucrose, and add sucrose amount 1/2 water and 0.1% wine
Stone acid.Heating is tempered, and is stirred continuously, until being concentrated into " wire drawing state ", is obtained final product.
Although the present invention is disclosed as above with preferred embodiments, so which is not limited to the present invention, any affiliated technology neck
The technical staff in domain, without departing from the spirit and scope of the present invention, when can make a little change and improve, therefore the present invention
Protection domain is when being defined so that claim is defined.
Claims (8)
1. a kind of compositionss with anti-senescence function, is characterized in that being made up of the following raw material：Radix Ginseng, Rhizoma Polygonati, Radix Rehmanniae, Tianmen
Winter, Mel, Poria, wherein the weight of the raw material is：Radix Ginseng 8～11, Rhizoma Polygonati 4～7, Radix Rehmanniae 2.5～5, Radix Asparagi 3
～6, Mel 3～4, Poria 4～6.
2. a kind of preparation method of the compositionss as claimed in claim 1 with anti-senescence function, comprises the steps：
1) crude drug Radix Ginseng, Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi, Mel, Poria are weighed, wherein Radix Ginseng, Poria are crushed respectively, is obtained
Radix Ginseng powder, Poria powder, it is standby；
2) crude drug Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi are mixed after Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi mixed material, are added water, to mixed
Compound material carries out heating extraction, collects extracting solution；
3) concentration is carried out to extracting solution, makes the concentrated extract of Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi；
4) crude drug Poria powder, Radix Ginseng powder and Mel are added to into concentrated extract mixing, are dried, obtain final product.
3. preparation method as claimed in claim 2, is characterized in that step 1) described in Radix Ginseng powder, Poria powder granularity be 60-
180 mesh.
4. preparation method as claimed in claim 2 or claim 3, is characterized in that step 2) described in heating extraction include that order below is entered
Capable step：
A) add water in mixed material, soak, then carry out first time heating extraction, wherein, the weight of the water of addition with it is mixed
The ratio of the gross weight of compound material is 6-12：1, heating-up temperature is 40-100 DEG C, and the heating extraction time is 1-4 hours；
B) first time extracting solution is filtered, filtrate is collected；
C) water is added in filtering residue, carry out second heating extraction, wherein, the weight of the water of addition and the weight ratio of mixture
For 6-12：1, heating-up temperature is 40-100 DEG C, and the heating extraction time is 1-4 hours；
D) filter, the filtrate filtered twice is merged.
5. preparation method as claimed in claim 4, is characterized in that also including step E)：After filtering to second heating extraction
Water is added in filtering residue, third time heating extraction is carried out, wherein, the weight of the water of addition is 6-12 with the weight ratio of mixture：
1, heating-up temperature is 40-100 DEG C, and the heating extraction time is 1-4 hours；Then filter, filtrate merges.
6. preparation method as claimed in claim 4, is characterized in that step A) described in soak time be 20-90min.
7. preparation method as claimed in claim 2 or claim 3, is characterized in that step 3) described in control temperature during concentration
For 40-100 DEG C.
8. a kind of preparation method of the compositionss as claimed in claim 1 with anti-senescence function, comprises the steps：
1) crude drug Radix Ginseng, Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi, Mel, Poria are weighed, wherein Radix Ginseng, Poria are crushed respectively, is obtained
Radix Ginseng powder, Poria powder, it is standby；
2) crude drug Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi are mixed after Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi mixed material, are added water, to mixed
Compound material carries out heating extraction, collects extracting solution；
3) concentration is carried out to extracting solution, makes the concentrated extract of Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi；
4) crude drug Poria powder and Mel are added to into concentrated extract mixing, crushed after being dried is obtained dry extract powder；
5) Radix Ginseng powder is added in dry extract powder, mix homogeneously is obtained final product.
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| CN112137088A (en) * | 2020-09-24 | 2020-12-29 | 琛蓝(美国)营养制品股份有限公司 | Compound composition with antioxidant and anti-aging effects and preparation method and application thereof |
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| 从琼玉膏的历史沿革看中医膏方文化的发展;农汉才等;《中医药文化》;20091215(第06期);第19-20页 * |
| 琼玉膏的临床疗效(第1报);王树芬;《国外医学.中医中药分册》;19950415;第17卷(第02期);第36页 * |
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