CN103719493B - Siberian solomonseal rhizome health-care tea of a kind of brain-nourishing intelligence-benefiting and preparation method thereof - Google Patents

Abstract

The invention provides a kind of sealwort galangal fruit health-care tea, in described Siberian solomonseal rhizome health-care tea, the parts by weight of various raw material are: sealwort 10 ~ 50 parts, fructus alpiniae oxyphyllae 10 ~ 20 parts, polygala root 10 ~ 20 parts, 10 ~ 20 parts, cultivated land, Radix Angelicae Sinensis 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, Psoralea corylifolia 10 ~ 20 parts, fushen 10 ~ 20 parts, walnut kernel 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, the seed of Oriental arborvitae 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, the root of herbaceous peony 10 ~ 20 parts, 10 ~ 20 parts, the fruit of Chinese magnoliavine, the bighead atractylodes rhizome 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Polygonum multiflower knotweed 10 ~ 20 parts, grass-leaved sweetflag 10 ~ 20 parts, mulberries 10 ~ 20 parts.The present invention has tonifying kidney and benefiting sperm, reduce phlegm out steal, the effect of brain-nourishing intelligence-benefiting, invigorating blood circulation addiction.Sealwort galangal fruit health-care tea contains neurotrophic factor sample ingredient, vascular factor can be promoted to cause with the reparation of memory about destroying brain tissue, make neurotransmitter AHC secretion increase.Improve SOD active, reduce excitatory amino acid, content of oxygen free radical in brain tissue.

Description

Siberian solomonseal rhizome health-care tea of a kind of brain-nourishing intelligence-benefiting and preparation method thereof

Technical field

The present invention relates to the benefit brain health-care product containing deriving from plant composition, particularly a kind of Siberian solomonseal rhizome health-care tea and preparation method thereof of brain-nourishing intelligence-benefiting.

Background technology

Present brain worker gets more and more, and many people start to occur overstrain one's nerves symptom, as decrease of memory, thought slowness etc.But, still have a lot of people overstrain one's nervesly not know for how being only, also understanding lacked for overstrain one's nerves harm.Expert points out, for a long time overstrain one's nerves do not note adjustment, the diseases such as possible inducing neural is weak, insomnia.Therefore, should make great efforts to avoid overstrain one's nerves generation.About overstrain one's nerves symptom, common are following several:

Feel dizzy, Hearing, auricular concha generates heat; Limbs fatigue, drowsiness or sleepy; Notice can not be concentrated, decrease of memory, and thinking owes quick, slow in reacting; There is Nausea and vomiting phenomenon etc.

Seen above overstrain one's nerves symptom, someone may say, a lot of disease all may occur these symptoms.So, what in the end be only overstrain one's nerves? expert interpretation, overstrain one's nerves people, brain produces fatigue state, show as giddy, headache, dim eyesight, comprehension and decrease of memory, slow in reacting, and a series of syndrome such as study and work efficiency reduction, be called and excessively use brain syndrome.Generally, the physical and mental health of overstrain one's nerves meeting to human body causes great harm, is mainly manifested in following two aspects:

1, physiological function is unbalance: absent minded, can't help give free rein to fancy, attend class wander, thought deserts, thus affects memory, thinking ability, impact study, sleep rule is abnormal, daytime lassitude, attend class easily sleepy, yawn, brain has dizzy spells, after bed at night, brain but psychs up, and thoughts thronging one's mind, are difficult to fall asleep, random dream is diverse and confused, even Morning Has Broken, and after waking up, brain is fatigue especially, is unable to pull oneself together.

2, mental function is unbalance: because the unbalance symptom of above-mentioned all physiological functions annoyings teenager, cause adolescent psychology function unbalance, show as worry, anxiety, depression, agitation, passiveness, sensitivity, suspicious, feel oneself inferior, feel guilty, thwack spirit on the surface, heart is full of puzzled and painful, helpless and know which way to go, then produce be weary of studying, play truant, run away from home, calf love, unmarried sexual behaviour, sexual crime, even produce thoughts of suicide.

Expert emphasizes, for a long time the overstrain one's nerves physiology that causes and mental function unbalance, a series of serious phrenoblabia diseases such as possible inducing neural is weak, insomnia.Therefore, must not adopt a casual attitude for overstrain one's nerves, should be taken precautions against in time.

Sealwort is used as medicine with rhizome.There is boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney benefiting functions.Be used for the treatment of weakness of the spleen and the stomach, fatigue and asthenia, dry food is few, deficiency syndrome of the lung cough caused by dryness, asthenia of essence and blood, and interior heat such as to be quenched one's thirst the disease.Very effective in cure for diabetes.Sealwort main product in Hebei, the Inner Mongol, the provinces and regions such as Shaanxi Province.David's-harp main product in Guizhou, Hunan, Yunnan, Anhui, the province such as Zhejiang.P. kingianum main product in Guizhou, Guangxi, the provinces and regions such as Yunnan.Property sugariness put down, return spleen; Lung; Kidney channel is boosting qi and nourishing yin, invigorating the spleen, moistening lung, the good medicine of kidney-nourishing.Cure mainly deficiency of Yin labor to cough; Xeropulmonary cough; Insufficiency of the spleen weak; The few dry of food; Quench one's thirst; Deficiency of the kidney soreness and weakness of waist and knees; Impotence and seminal emission; Tinnitus order is dark; Poliosis; Body void is won thin; Wind favus disease.

Sealwort has hypotensive, hypoglycemic, reducing blood lipid, atherosclerosis, and delay senility and effect such as antibacterial grade, Siberian solomonseal rhizome polysaccharide has Immunestimulatory effect.For the lung-dryness syndrome due to yin deficiency, the few phlegm of dry cough, and the labor of lung-kidney deficiency is coughed chronic cough etc.For weakness of the spleen and the stomach.Both tonifying spleen-yin, again beneficial temper, obtain dizzy, soreness and weakness of waist and knees for deficiency of kidney essence, poliosis and quenching one's thirst.The good medicine of nourishing of good moistening lung help.But medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.How the efficacy exertion of sealwort not being injured human body again to maximum, is our problem in the urgent need to address.

Overstrain one's nerves meeting causes vegetative dystonia, thus causes cerebrovascular shrink function abnormal, blood supply insufficiency, occurs the symptoms such as dizziness headache is uncomfortable in chest.To touch upon the main blood of liver according to blood stasis, adjust the theory of blood, adopt promoting blood circulation and removing blood stasis, soothing the liver tune blood (namely nursing one's health cerebrovascular wall systolic and diastolic function) and reach therapeutic purposes.Sealwort can use for a long time just and not injure human body, and can significantly improve memory, recovers the good timber of brain nutrition.How to develop effect of sealwort, be only the direction of our research.

Summary of the invention

Technical problem to be solved by this invention is, modern brain worker gets more and more, and many people start to occur overstrain one's nerves symptom, as decrease of memory, thought slowness etc.Overstrain one's nerves meeting causes vegetative dystonia, thus causes cerebrovascular shrink function abnormal, blood supply insufficiency, occurs the symptoms such as dizziness headache is uncomfortable in chest.Now commercially occur the health products of various brain-nourishing intelligence-benefiting, great majority are amusements of businessman's false propaganda, do not have what health care at all, also allow people waste wealth.The present invention has tonifying kidney and benefiting sperm, reduce phlegm out steal, the effect of brain-nourishing intelligence-benefiting, invigorating blood circulation addiction.Sealwort galangal fruit health-care tea contains neurotrophic factor sample ingredient, vascular factor can be promoted to cause with the reparation of memory about destroying brain tissue, make neurotransmitter AHC secretion increase.Improve SOD active, reduce excitatory amino acid, content of oxygen free radical in brain tissue, suppress the activation of cerebral cortex excitatory amino acid receptor, play nourishing brain cell, protect brain cell, improve brain function, improve cognitive ability.Add some mouthfeels light, do not affect the Chinese medicine of King solomonseal rhizome tea taste, make people be easy to accept, effect of brain-nourishing intelligence-benefiting can be reached preferably.

For solving above-mentioned technical barrier, the invention provides a kind of Siberian solomonseal rhizome health-care tea of brain-nourishing intelligence-benefiting, the parts by weight of the various raw materials of Siberian solomonseal rhizome health-care tea described in it are: sealwort 10 ~ 50 parts, fructus alpiniae oxyphyllae 10 ~ 20 parts, polygala root 10 ~ 20 parts, 10 ~ 20 parts, cultivated land, Radix Angelicae Sinensis 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, Psoralea corylifolia 10 ~ 20 parts, fushen 10 ~ 20 parts, walnut kernel 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, the seed of Oriental arborvitae 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, the root of herbaceous peony 10 ~ 20 parts, 10 ~ 20 parts, the fruit of Chinese magnoliavine, the bighead atractylodes rhizome 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Polygonum multiflower knotweed 10 ~ 20 parts, grass-leaved sweetflag 10 ~ 20 parts, mulberries 10 ~ 20 parts.

The Siberian solomonseal rhizome health-care tea of described brain-nourishing intelligence-benefiting, the parts by weight of the various raw materials of smart health protection tea described in it can be: sealwort 10 ~ 30 parts, fructus alpiniae oxyphyllae 10 ~ 15 parts, polygala root 10 ~ 15 parts, 10 ~ 15 parts, cultivated land, Radix Angelicae Sinensis 10 ~ 15 parts, root tuber of aromatic turmeric 10 ~ 15 parts, Psoralea corylifolia 10 ~ 15 parts, fushen 10 ~ 15 parts, walnut kernel 10 ~ 15 parts, Radix Codonopsis 10 ~ 15 parts, the seed of Oriental arborvitae 10 ~ 15 parts, the Radix Astragali 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, the root of herbaceous peony 10 ~ 20 parts, 10 ~ 20 parts, the fruit of Chinese magnoliavine, the bighead atractylodes rhizome 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Polygonum multiflower knotweed 10 ~ 20 parts, grass-leaved sweetflag 10 ~ 20 parts, mulberries 10 ~ 20 parts.

The Siberian solomonseal rhizome health-care tea of described brain-nourishing intelligence-benefiting, the parts by weight of the various raw materials of Siberian solomonseal rhizome health-care tea described in it can also be: sealwort 10 ~ 40 parts, fructus alpiniae oxyphyllae 10 ~ 20 parts, polygala root 10 ~ 20 parts, 10 ~ 20 parts, cultivated land, Radix Angelicae Sinensis 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, Psoralea corylifolia 10 ~ 20 parts, fushen 10 ~ 20 parts, walnut kernel 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, the seed of Oriental arborvitae 10 ~ 20 parts, the Radix Astragali 10 ~ 15 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 15 parts, the root of herbaceous peony 10 ~ 15 parts, 10 ~ 15 parts, the fruit of Chinese magnoliavine, the bighead atractylodes rhizome 10 ~ 15 parts, Flos Albiziae 10 ~ 15 parts, Polygonum multiflower knotweed 10 ~ 15 parts, grass-leaved sweetflag 10 ~ 15 parts, mulberries 10 ~ 15 parts.

For solving the problems of the technologies described above, the invention provides a kind of preparation method of Siberian solomonseal rhizome health-care tea of brain-nourishing intelligence-benefiting, described in it, the preparation process of Siberian solomonseal rhizome health-care tea comprises following aspect:

A. the preparation of sealwort;

B. described other raw materials pulverized, soak, heating, refluxing extraction 2 times;

C. again the concentration of liquid medicine that surplus stock extracts is become granule, pulvis or paste;

D. concentrated granule, pulvis or paste are mixed with the sealwort prepared, be prepared into health protection tea.

In described step a, the sealwort of results can be cleaned, the airing time, at 7-12 hour, parches; Be cut into thin slice, put water proof in pot and steam 30-60 minute at 80-100 DEG C, then dry; Repeat again after drying to steam once, dry; Repeat again to steam and shine once; Then put into large iron pan to stir-fry, on first backward downwards, firmly want evenly, when sealwort color starts blackout, start little fire stir-fry 30-45 minute shaping; When color becomes pitchy, naturally dry after taking out.

In described step b, surplus stock can be cleaned impurity elimination, dry, be ground into particle, soak 1 hour; Soaked raw material is put boiling secondary in multi-function extractor; Add up the water of medicinal material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters.

In described step c, the filtrate of filtration can be inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, convection drying powdered.

In described steps d, sealwort good for frying can be mixed with powder prepared by surplus stock, ultraviolet disinfection, packs and get final product.

For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method of Siberian solomonseal rhizome health-care tea of brain-nourishing intelligence-benefiting, and when paste made by other raw materials of described Siberian solomonseal rhizome health-care tea, step is:

A, get bulk drug and put into ethanol and soak, heat is extracted 2 times, and becoming paste, is component 1;

B, dregs of a decoction extracting in water 2 times, thickening filtration is paste, is component 2;

C, merged by above-mentioned two kinds of pastes, sealwort good with frying after ultraviolet radiation for sterilizing and disinfecting merges to be packed.

The preparation method of the Siberian solomonseal rhizome health-care tea of described brain-nourishing intelligence-benefiting, when paste made by other raw materials, in described step a, raw material can be got add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use, becomes component 1; In described step b, the dregs of a decoction that alcohol extract is crossed can be put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, and 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use, becomes component 2.

The technique effect that the present invention is useful is, modern brain worker gets more and more, and many people start to occur overstrain one's nerves symptom, as decrease of memory, thought slowness etc.Overstrain one's nerves meeting causes vegetative dystonia, thus causes cerebrovascular shrink function abnormal, blood supply insufficiency, occurs the symptoms such as dizziness headache is uncomfortable in chest.Now commercially occur the health products of various brain-nourishing intelligence-benefiting, great majority are amusements of businessman's false propaganda, do not have what health care at all, also allow people waste wealth.Sealwort sugariness is put down, and returns spleen; Lung; Kidney channel is boosting qi and nourishing yin, invigorating the spleen, moistening lung, the good medicine of kidney-nourishing.The present invention has tonifying kidney and benefiting sperm, reduce phlegm out steal, the effect of brain-nourishing intelligence-benefiting, invigorating blood circulation addiction.Sealwort galangal fruit health-care tea contains neurotrophic factor sample ingredient, vascular factor can be promoted to cause with the reparation of memory about destroying brain tissue, make neurotransmitter AHC secretion increase.Improve SOD active, reduce excitatory amino acid, content of oxygen free radical in brain tissue, suppress the activation of cerebral cortex excitatory amino acid receptor, play nourishing brain cell, protect brain cell, improve brain function, improve cognitive ability.The most mouthfeel of these medicinal materials is light, does not affect the taste of King solomonseal rhizome tea, does not have the unpleasant taste of traditional Chinese medicine being difficult to swallow, and makes people be easy to accept, can long-term taking, more can reach effect of brain-nourishing intelligence-benefiting preferably.

Detailed description of the invention

Sealwort is conventional tonic Chinese herbal medicine, has the medication history of more than 2000 year in China, is Liliaceae Polygonatum herbaceos perennial, its rhizome medicinal.Sealwort is flat, taste is sweet, returns spleen, lung, kidney channel, has effect of tonifying spleen moistening lung, supplementing qi and nourishing yin, be used for the treatment of the diseases such as body void is weak, palpitation, dryness of the lung dry cough, ringworm of the body.

In recent years, the research of people to sealwort and HUANGJING ZANYU CAPSULE thereof deepens continuously, and from sealwort plant, be separated the chemical composition obtained has alkaloid, flavones, quinones, lignanoid, polysaccharide, steroid saponin and trace element etc.

1, blood sugar effect is regulated

Siberian solomonseal rhizome polysaccharide has no significant effect normal mouse blood sugar level, but significantly can reduce the blood glucose value of the hyperglycaemia mouse that adrenaline brings out, and reduces the content 8A of CAMP cAMP in adrenaline model mice liver simultaneously:.Normal mouse abdominal cavity gives sealwort methanolic extract 800mg/kg, blood sugar can be made after 4h to drop to (144 ± 13) mg/dL from (220 ± 7) mg/dL, the blood sugar that under similarity condition, streptozotocin (STZ) brings out hyperglycaemia mouse (insulin-dependent model) drops to (396 ± 15) mg/dL from (589 ± 34) mg/dL, but it is while hypoglycemic activity, do not change serum insulin level.This extract also has the effect suppressing adrenaline to bring out hyperglycaemia mouse blood sugar.Someone is separated from its active site and obtains 2 active components, through being accredited as spirostanolglycoside.

2, immunity moderation effect

Found by the impact test of high, medium and low dosage Siberian solomonseal rhizome polysaccharide on Phagocytosis By The Peritoneal Macrophages In Mice, mouse Hemolysin formation and delayed allergy (DTH), the immunoregulation effect of Siberian solomonseal rhizome polysaccharide clearly, not only can strengthen mouse humoral immune function, also can strengthen the function of mouse cell immunity.Immunocompetence screening shows, sealwort can improve the hemopoietic function of bone marrow by endoxan process mouse, and make its leucocyte and erythrocyte number increase, Micronucleus declines, and the phagocytic function of Turnover of Mouse Peritoneal Macrophages improves.To every mouse with sealwort decocting liquid 0.5g/d continuously feed raise 10d, result normal mouse plasma cAMP, cyclic guanosine monophosphate (cGMP) content reduce, especially reduce significantly with cGMP, cAMP/cGMP ratio slightly raises (comparing without significant difference with control group); Normal mouse spleen organizes the content of cGMP but obviously to raise.

3, learning and memory effect is improved

Cause the continuous gavage of learning memory disorder model mice with saponins of rhizoma polygonati (PTS) to scopolamine, result display PTS obviously can improve the learning and memory function of model mice under 400mg/kg dosage.Siberian solomonseal rhizome polysaccharide 200, 100, 50mg/kg3 dosage (is hydergene as positive control to respectively the continuous gavage 15d. of old rats, negative control is equivalent distilled water), within after administration the 15th day and the 30th day, carry out learning test with y type labyrinth, result shows that Siberian solomonseal rhizome polysaccharide significantly can improve old rats learning and memory and memory reproduction, reduce errors number (compared with positive control, Siberian solomonseal rhizome polysaccharide 200mg/kg and 100mg/kg dosage group difference are all extremely significantly (P < 0.01), 50mg/kg dosage group significant difference (P < 0.05).To vascular dementia rat models with every 100g body weight 0.5ml gavage 1 week, then continue medication 1.5 months and 2.5 months (naturally taking drink) with 10% Siberian solomonseal rhizome health-care tea, result shows that Siberian solomonseal rhizome health-care tea has the effect reinvented synaptic structure and function, improve vascular dementia SD female rats ability of learning and memory.

4, antifatigue effect

Mouse peritoneal injection sealwort solution 12g/kg, can significantly improve mouse hypoxia-bearing capability; With sealwort water decoction 2.55g/kg gavage mouse, can significant prolongation mouse swimming time (P < 0.05).

5, Regulation serum lipids

The new zealand purebred rabbit 30 (male and female half and half) after High cholesterol diet is fed is given with basic, normal, high dosage Siberian solomonseal rhizome polysaccharide, result animal used as test sustainer general form and om observation display, Siberian solomonseal rhizome polysaccharide high dose group aortic tunica intima foam wanshing obviously reduces (P < 0.05), shows that doses Siberian solomonseal rhizome polysaccharide has the effect reducing hyperlipidemia animal used as test blood fat and the effect suppressing endarterium foam wanshing.In addition, Siberian solomonseal rhizome polysaccharide obviously reduces in Ad model mice liver, the content of cAMP, thus infer that its hypoglycemic mechanism is reduction of in liver cell, the content of cAMP, hinders phosphorylase and activates and Glycogen synthesis enzyme deactivation, thus causes that Glycogen synthesis accelerates, decomposition of glycogen slows down.Siberian solomonseal rhizome polysaccharide reduces, the mechanism of cAMP may with it has impact on the expression of adrenocepter or cause the conformational change of acceptor relevant, this respect also needs to study confirmation further.

6, delaying senility function

With Siberian solomonseal rhizome health-care tea 0.2, the continuous gavage mouse of 0.4ml/d 4 weeks (making the positive, negative control respectively with American ginseng health tea and water respectively), put to death after swimming 90min, this health protection tea of result significantly can reduce the heart, liver lipid peroxide LP0) generate P < 0.01, increase glutathione peroxidase activity and blood superoxide dismutase SOD vigor, and in dose dependent; Compared with positive controls, Siberian solomonseal rhizome health-care tea suppresses the heart, liver LPO generative capacity obviously increases, and also in dose dependent, shows it and has anti-ageing anti-old effect.Have studied the Antioxidation in vitro of Siberian solomonseal rhizome polysaccharide, result shows it can suppress generation that is spontaneous and the lipid peroxidation product MDA (MDA) of induction in vitro, to oxygen radical, there is direct scavenging action, show Siberian solomonseal rhizome polysaccharide anti-oxidant and anti-aging in there is certain effect.

Along with to sealwort pharmacology, pharmaceutical chemistry and clinical research progressively deeply, people find gradually and confirm that in sealwort plant, steroid saponin and analogous components thereof have some good pharmacologically actives, and existing patent application, as patent such as " steroid saponin in Chinese medicine sealwort and medical usage and preparation method " thereof of Lee's milling.Simultaneously, based on the active site of HUANGJING ZANYU CAPSULE and the research of active ingredient, people are also carrying out New Drug Research, sealwort and glycocalix thereof have made some Chinese patent drugs evident in efficacy, health products, new antiviral drug, health protection tea, as Siberian solomonseal rhizome polysaccharide eye drops, antiviral Siberian solomonseal rhizome polysaccharide sulfuric ester, the Wonderful creme of Prevention and Curation genital herpes and spray, ancient crane pine health liquor, Siberian solomonseal rhizome polysaccharide health protection tea, sealwort radix paeoniae rubrathe parenteral solution, the sealwort medicinal extract etc. of tool deferring senility.

All on the books to sealwort in " Chinese medicine voluminous dictionary " and pertinent literature: can calm the nerves, wind pain is swollen in the wide intestines of lively atmosphere blood, sending down abnormally ascending, heat-clearing, long-pendingization of dispelling is stagnant, gut purge, ease constipation, invigorating the spleen moistening lung, cough-relieving, relieving asthma, anti-inflammatory, antiallergy, cardiac stimulant, invigorating the spleen moistening lung, the effect such as beauty treatment., be not medicine, be not health products to sealwort--seven major nutrient complete set, is to work as the food that meal eats, and but has remarkable healthy nutritive value and outstanding dietotherapy effect.

The flat taste of the seed of Oriental arborvitae is sweet, the heart, kidney, large intestine channel.Tool mental-tranquilization, the effect relaxed bowel.Control the diseases such as palpitation with fear, insomnia, seminal emission, night sweat, constipation, energy mental-tranquilization, relaxes bowel.For restlessness of asrhenia type and insomnia, palpitation and severe palpitation, intestines are dry makes the secret disease that Dengs." medicineization justice ": the seed of Oriental arborvitae, the saturating heart of fragrance, body profit grows blood.Same fushen, jujube kernel, the dried rhizome of rehmannia, the tuber of dwarf lilyturf, be product clear in turbid, cure mainly mind void timid, palpitate with fear the second month in a season seized with terror, color is wan and sallow, and skin is dry itches, and the merit of the blood that all nourishes heart also.Get again smell all dense, return kidney in turbid, same to cultivated land, tortoise version, matrimony vine, the root of bidentate achyranthes, be packing marrow, cure mainly damage of kidney-YIN, back grave illness, sufficient knee is weak, and night sweat due to yin deficiency, the power that all nourshing kidney is dry also.Taste is sweet also can delay liver, the deficiency of tonifying liver courage, extremely reliable, but the flat power of property delay, should be multiplex be wonderful.

Polygala root is bitter, pungent, tepor.The thoughts of returning home, kidney, lung channel.Function cures mainly intelligence development of calming the nerves, and eliminates the phlegm, detumescence.For the insomnia and dreamful sleep that breakdown of the normal physiological coordination between the heart and the kidney causes, forgetful palpitation with fear, wandering, expectoration is not well, sore swollen toxin, mastosis.Be applied to insomnia and dreamful sleep, palpitation and severe palpitation, forgetful.This product toil is warm in nature, property is kind lead off sensible, can happily gas and antitoxic heart-soothing and sedative, kidney qi can be led to and strong will is not forgotten, be restoring normal coordination between heart and kidney, stabilize mind, good merchantable brand that intelligence development is known by force.Cure mainly the having no peace of mind of breakdown of the normal physiological coordination between the heart and the kidney, have a sleepless night, the disease such as palpitation with fear, normal with fushen, dens draconis, cinnabar etc. the same use of medicinal for tranquilizing mind, as polygala root ball (" Zhang Shi doctor is led to "); Control forgetful card, normal and ginseng, Poria cocos, the same use of calamus, as Kaixin San (" prescriptions worth thousand gold "), if Fang Zhongzai adds fushen, namely do not forget fall apart (" Standards of Diagnosis and Treatment ")." book on Chinese herbal medicine is just ": polygala root, the wholwe-hearted kidney of merit, therefore can only shy by relieving palpitation, the peace that exorcises evil spirits dream, Yang strengthening and life essence tonifying, strong will power-assisted.With its gas lift, thus same ginseng, Radix Glycyrrhizae, jujube kernel, pole can lift fall into take the photograph essence, handing-over extreme misery.

The Chinese medicine fleece-flower root have Radix Polygoni Multiflori and RADIX POLYGONI MULTIFLORI PREPARATA point, direct slicing is used as medicine for Radix Polygoni Multiflori, dries be used as medicine for RADIX POLYGONI MULTIFLORI PREPARATA with black soya bean liquor after mixing steaming.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, the carbuncle that disappears, relax bowel, and is usually used in treatment scrofula sore carbuncle, rubella itch, the dry constipation of intestines; The filling liver kidney of RADIX POLYGONI MULTIFLORI PREPARATA function, benefiting essence-blood, black beard and hair, strengthening the bones and muscles, under sallow for the deficiency of blood, dizzy tinnitus, poliosis, soreness and weakness of waist and knees, extremity numbness, uterine bleeding band, chronic malaria body is empty etc.RADIX POLYGONI MULTIFLORI PREPARATA of the present invention is the good merchantable brand of invigrating kidney.

Cortex albiziae nature and flavor are sweet, flat.There is the merit of Xie Yu and blood, Ning Xin, subduing inflammation.Have and control that confused and worried, melancholy, insomnia, lung carbuncle, carbuncle are swollen, the effect of scrofula, injured bone." book on Chinese herbal medicine is looked for the truth ": " cortex albiziae.Why silk tree is named, and the internal organs peace of its clothes is supported, and makes us joyous happy, therefore with joyous name." herbal classic ": main five viscera settling, and will, makes us happy carefree.Under being usually used in the unsuccessful melancholy of feelings will and induced insomnia person, having no peace of mind etc., clinically manyly to join with the seed of Oriental arborvitae, the heart, spina date seed is equal to use, to strengthen strongly fragrant, tranquilizing the mind effect of nourishing heart out.

Walnut kernel nature and flavor are sweet, temperature.Return kidney, lung, large intestine channel.Kidney tonifying, warm lung, ease constipation.For soreness and weakness of waist and knees, impotence and seminal emission, the cold of insufficiency type is breathed heavily and is coughed, constipation.Brain tonic is anti-old: walnut kernel contains more protein and the required unrighted acid of human nutrition, and these compositions are all the important substance of cerebral tissue cellular metabolism, can nursing brain cells, strengthens brain function.

Fushen's taste is sweet, light, property is put down, and is used as medicine and has the function of clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Nature and flavor are sweet, light flat.There are the functions such as excreting dampness, invigorating the spleen, Ning Xin.For phlegm and retained fluid, oedema, difficult urination, have loose bowels, palpitaition, dizzy.Fuling peel, inducing diuresis for removing edema, the diseases such as the edema that wets for water, for palpitation with fear of having a guilty conscience, forgetful, insomnia, frightened epilepsy, difficult urination." not Lu ": treat wind dizzy, wind be empty, the exhaustion or lesion of the five internal organs, dry.Only palpitation with fear, is enraged more, forgetful.Happy intelligence development, supports spirit.

The Radix Astragali has the effects such as invigorating qi for strengthening superficies, sharp water detumescence, pus draining and toxin expelling, myogenic.The history of medicinal existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing the various trace elements such as saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhanced machine body immunity function, protect the liver, diuresis, anti-ageing, resisting stress, step-down and antibacterial action more widely.But table is real evil to be contained, retention of dampness due to stagnation of QI, and dyspepsia is stagnated, ulcer from the beginning of or the real example such as routed after heat poison Shang Sheng.The Radix Astragali has invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, and ulcer difficulty is burst, and burst for a long time and do not hold back, the deficiency of blood is sallow, and interior heat is quenched one's thirst." herbal classic " is recorded: " main ulcer, loses sore for a long time, apocenosis pain relieving.Qi-restoratives, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas to strengthen the bone, put on flesh and enrich blood.”

Mulberries: nourishing yin and nourishing blood medicine; Promote the production of body fluid medicine; Aperitive.Modern study confirms, containing the abundant composition such as activated protein, vitamin, amino acid, carrotene, mineral matter, resveratrol, anthocyanidin in mulberries fruit, nutrition is 5 ~ 6 times of apple, it is 4 times of grape, there is multiple efficacies, be described as " the best health fruit of 21st century " by medical circle.Often eat mulberries and can significantly improve body immunity, have and delay senility, effect of beautifying face and moistering lotion.Traditional Chinese medicine thinks that mulberry fruit taste is sour, cold nature, have improve body immunity, enriching yin of enriching blood, promote the production of body fluid to quench thirst, the effect such as dry is dispelled in ease constipation, cure mainly deficiency of YIN-blood and cause have a dizzy spell, tinnitus palpitaition, irritated insomnia, soreness and weakness of waist and knees, poliosis, quench one's thirst only do, dry and hard excrement, nourishing yin and supplementing blood, improving eyesight are calmed the nerves, sharp joint, curing rheumatism, the effect such as to relieve the effect of alcohol.

Radix Angelicae Sinensis, its taste is sweet and weigh, therefore specially can enrich blood, and its gas is light and pungent, therefore again can promoting circulation of blood, and bowl spares has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, tonifying Qi production of sperm, five viscera settling, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain defaecation of dispelling, relieving rigidity of muscles and joints, controls contraction, paralysis, the card such as dry, puckery.Empty and the exterior syndrome being not relieved person of battalion, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, can fall apart greatly Biao Weire, and show not hold back person, helps with rheum officinale and so on, can admittedly show again.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

The root of herbaceous peony enters liver, the spleen channel, nourishing blood and liver, pain relieving in slow, and astringe yin receives sweat.Control chest abdomen pain over the hypochondriac region, rush down dysentery stomachache, spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, under band, married woman's blood closes obstructed, and disappear hemostasis, can lose purulence, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, brings down a fever, relieving restlessness, beneficial gas, the capable hot disease in sky, pest miasma, frightened mad, and married woman's blood is transported, and intestines wind, rushes down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, sore scabies, headache, improving eyesight, hot eyes exerts meat.The many tonifying Qi of redness of the skin or complexion person, white person controls blood.

Cultivated land has another name called prepared rhizome of rehmannia or throws oneself on the ground, belong to goatweed, be a kind of first-class Chinese medicine, there is enriching yin effect of enriching blood, can be used for the deficiency of blood sallow, dizzy, palpitation and insomnia, irregular menstruation, the diseases such as uterine bleeding, also diseases such as can be used for hectic fever hectic fever due to yin, the night sweat of the deficiency of the kidney yin, pass out semen, quench one's thirst is one of asthenic symptoms class non-prescribed medicine medicine Liuwei Dihuang Wan main component.This quality is moistened into kidney, and kind nourishing kidney yin, life essence-filling, marrow-benefitting is the key medicine of tonifying kidney-yin.Ancients call it " large tonifying five zang organs is Kidney-Yin ", " the true water of large benefit ".Often be equal to use with Chinese yam, Fructus Corni, the treatment deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, seminal emission, night sweat, tinnitus, deafness and quench one's thirst, can filling liver kidney, beneficial marrow, as Liuwei Dihuang Wan.

Flos Albiziae contains silk tree glucoside, tannin, resolving stagnation for tranquilization, appetizing of regulating the flow of vital energy, activating collaterals to relieve pain, for confused and worried, melancholy insomnia.Control pent-up uncomfortable in chest, insomnia, forgetful, acute conjunctivitis, can five viscera settling, and will, happy color, have keep fit preferably, calm, the effect of calming the nerves, improve looks, be also treat neurasthenic good merchantable brand.Also have clearing away summerheat, face-beautifying and spot-removing such as to relieve the effect of alcohol at the effect." herbal warp " is said: " Flos Albiziae energy five viscera settling, and will, happy color." especially to pregnant woman, have keep fit preferably, calm, the effect of calming the nerves, improve looks, be also treat neurasthenic good merchantable brand.

Fruit of Chinese magnoliavine temperature; Sour, sweet; Return lung, the heart, kidney channel; Restrain astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney calming.Breathe heavily for void of coughing for a long time, emission, enuresis frequent micturition, endless diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and feeble pulse of losing heart, interior heat is quenched one's thirst, palpitation and insomnia." Bencao Jingshu " carries: the main beneficial gas person of the fruit of Chinese magnoliavine, all gas of lung master, and acid can be received, and just entering lung tonifying lung, therefore beneficial gas also.Its main cough with dyspnea person, the deficiency of vital energy is then above stopped up and is not returned unit, sour flavor having the property of astringing, takes the photograph gas and returns unit, then cough with dyspnea is from removing.Internal lesion caused by overexertion is won thin, tonifying for the deficiency, reinforcing yin essence, beneficial man's essence." not Lu " supports the five internal organs, heat extraction, flesh person in raw the moon, the special kidney tonifying of the fruit of Chinese magnoliavine, tonifying five zang organs of holding concurrently, kidney storing essence, and essence is contained then cloudy strong, and receive and take the photograph, vital qi returns unit, and public region is warmed up, digesting food, steams waste matter and changes precise and tiny, then smart spontaneous, and essence is raw then cloudy long, therefore main as above all diseases also.

Polygonum multiflower knotweed is nourished heart, and calms the nerves, and dredging collateral dispels the wind, and the traditional Chinese medical science is thought, Polygonum multiflower knotweed property is put down nontoxic, sweet and slightly bitter taste, enters the heart, Liver Channel, has effect of tranquilizing and blood nourishing, dispelling wind and removing obstruction in the meridians, cures mainly the diseases such as deficiency of Yin blood is few, restlessness of asrhenia type and insomnia, arthralgia due to wind-dampness, itchy skin eruption.Compatibility of drugs: complex acid jujube kernel, grows the heart-yin, the peaceful mind; Join the dried rhizome of rehmannia, tonifying yin of nourishing blood; Join lucid asparagus, the tuber of dwarf lilyturf, the clear fire of deficiency type, nourish heart the moon; Join notopterygium root, levisticum, expelling wind and eliminating dampness, Shu Li joint.

Fructus alpiniae oxyphyllae taste is pungent; Warm in nature.Temperature kidney controlling nocturnal emission with astringent drugs contracting urine, warm spleen appetizing is taken the photograph phlegm temperature compensation and is admittedly taken the photograph, and warm spleen antidiarrheal ， Gu Dan takes the photograph saliva, and warm kidney controlling nocturnal emission with astringent drugs contracting urine, cures mainly spleen and suffer from a deficiency of the kidney cold, abdominal pain diarrhea; Or kidney qi cold of insufficiency type frequent urination, the enuresis, seminal emission, gonorrhoea; Or saliva outflow and can not effector in chronic diarrhea caused by deficiency-cold in spleen and stomach and mouth.The methanolic extract of intelligent promoting fruit has the activity strengthening guinea pig left atrium convergent force, its minimum effective dose is that 10-6g/m1. reporter thinks, the cardiotonic of yakuchinone first, in part because it to cardiac muscle in sodium potassium pump suppression caused by. No. 1, intelligence development is (by the fleece-flower root, grass-leaved sweetflag, the root of kudzu vine, ginkgo leaf, Ligusticum wallichii, the compositions such as the radix paeoniae rubrathe) effect is improved to the memory dysfunction caused because of five kinds of different chemicals. with intelligence development No. 1 25g/kg, 50g/kg was to mouse stomach 7 days, energy antagonism scopolamine 0.001g/kg and yellow Jackets 0.03g is to the destruction of Memory acquisition, improve memory consolidation that chloramphenicol 0.2g/kg and natrium nitrosum 0.12g/kg causes bad and improve the memory that 40% ethanol causes and lack again, there was no significant difference is compared with piracetam control group.

Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body.Baizhu volatile oil has inhibitory action to mouse EC, lymphosarcoma ascitic type, the cancer of the esophagus (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also remarkable inhibitory action is had." property of medicine opinion " carries it: monarch, taste is sweet, pungent, nontoxic.Energy main large wandering arthritis, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken place food that disappears, appetizing, removes sputum, except fever and chills, lets out under stopping.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells to vomit inverse, and crymodynia in abdomen, vomits and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.

Grass-leaved sweetflag is pungent, bitter, temperature.The thoughts of returning home, stomach warp.Dampness elimination is whetted the appetite, open-minded phlegm of having one's ideas straightened out, inducing resuscitation intelligence development.Not hungry for gastral cavity ruffian, a mouthful diarrhea of keeping silent, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, coma due to blocking of the respiratory system, pyreticosis coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, wind-cold-dampness arthralgia, swollen ulcer drug, traumatic injury." herbal classic ": " happy hole, tonifying five zang organs, logical nine orifices, improve visual and auditory acuity, goes out speech for main wind-cold-dampness arthralgia, cough with dyspnea." " not Lu ": " main deafness, carbuncle sore, warming intestines and stomach, only little facility, four limbs arthritis with fixed pain caused by dampness, must not bend and stretch, children's's a kind of malaria, and body accumulated heat is not understood, and can do to bathe soup.Clever knowledge, beneficial intelligence.

Psoralea corylifolia taste is pungent; Bitter; Warm in nature.Tonify the kidney and support yang; Promoting inspiration to relieve asthma; Warming spleen and stopping diarrha.The main insufficiency of the kidney yang; Below element deficiency and cold; Waist knee crymodynia; Impotence and seminal emission; Frequent micturition; The enuresis; The failure of the kidney in receiving air; Void is breathed heavily incessantly; Speen-kidney dificiency; Stool is rushed down for a long time; Outer for leucoderma; Alopecia areata; Psoriasis.Psoralea corylifolia and fructus alpiniae oxyphyllae, be all the ripening fruits of plant, is warm spleen and warms up kidney.But the large wet of Psoralea corylifolia is thick, taste is held concurrently bitter, therefore relatively goes down, and kind benefit fire from the gater of life, with kidney-Yang invigorating, is used for the cold person that suffers from a deficiency of the kidney; The thinner taste of fructus alpiniae oxyphyllae gas is stewed pungent, therefore in being partial to and, kind warm spleen soil, help the foundation of acquired constitution, is used for insufficiency of the spleen cold person.Compendium of Material Medica: control the kidney type diarrhea, the logical gate of vitality, warm public region, holds back spirit.

Specific embodiment 1:

First prepared by sealwort, stir-fry.

Again by all the other raw materials tubers of dwarf lilyturf, fructus alpiniae oxyphyllae, polygala root, cultivated land, Radix Angelicae Sinensis, root tuber of aromatic turmeric, Psoralea corylifolia, fushen, walnut kernel, Radix Codonopsis, the seed of Oriental arborvitae, the Radix Astragali, RADIX POLYGONI MULTIFLORI PREPARATA, the root of herbaceous peony, the fruit of Chinese magnoliavine, the bighead atractylodes rhizome, Flos Albiziae, Polygonum multiflower knotweed, grass-leaved sweetflag, mulberries, extract to concentrate and make granule, pulvis or paste.

Mix the extract of sealwort and other raw materials fried, ultraviolet radiation for sterilizing and disinfecting packs, and directly can take after mixing it with hot water during use.

Specific embodiment 2:

Get sealwort 5000g to clean, get the sealwort obtained and clean, the airing time, at 7-12 hour, parches; Be cut into thin slice, put water proof in pot and steam 30-60 minute at 80-100 DEG C, then dry; Repeat again after drying to steam once, dry; Then take after mixing it with water to steam and shine once; Then put into large iron pan to stir-fry, on first backward downwards, firmly want evenly, when sealwort color starts blackout, start little fire stir-fry 30-45 minute shaping; When color becomes pitchy, naturally dry after taking out; By surplus stock fructus alpiniae oxyphyllae 1500g, polygala root 1500g, cultivated land 1500g, Radix Angelicae Sinensis 1500g, root tuber of aromatic turmeric 1500g, Psoralea corylifolia 1500g, fushen 1500g, walnut kernel 1500g, Radix Codonopsis 1500g, seed of Oriental arborvitae 1500g, Radix Astragali 1500g, RADIX POLYGONI MULTIFLORI PREPARATA 1500g, root of herbaceous peony 1500g, fruit of Chinese magnoliavine 1500g, bighead atractylodes rhizome 1500g, Flos Albiziae 1500g, Polygonum multiflower knotweed 1500g, grass-leaved sweetflag 1500g, mulberries 1500g.Clean impurity elimination, dry, be ground into particle, soak 1 hour; Soaked bulk drug is put boiling secondary in multi-function extractor; Add up the water of medicinal material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds up the water of medicinal material 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, adds dextrin and make granule.Again the sealwort fried is mixed with the granule made, ultraviolet disinfection, pack and get final product.

Specific embodiment 3:

Get sealwort 4000g to clean, get the sealwort obtained and clean, the airing time, at 7-12 hour, parches; Be cut into thin slice, put water proof in pot and steam 30-60 minute at 80-100 DEG C, then dry; Repeat again after drying to steam once, dry; Then take after mixing it with water to steam and shine once; Then put into large iron pan to stir-fry, on first backward downwards, firmly want evenly, when sealwort color starts blackout, start little fire stir-fry 30-45 minute shaping; When color becomes pitchy, naturally dry after taking out; By surplus stock fructus alpiniae oxyphyllae 1200g, polygala root 1200g, cultivated land 1200g, Radix Angelicae Sinensis 1200g, root tuber of aromatic turmeric 1100g, Psoralea corylifolia 1200g, fushen 1200g, walnut kernel 1300g, Radix Codonopsis 1100g, seed of Oriental arborvitae 1200g, Radix Astragali 1200g, RADIX POLYGONI MULTIFLORI PREPARATA 1100g, root of herbaceous peony 1200g, fruit of Chinese magnoliavine 1200g, bighead atractylodes rhizome 1100g, Flos Albiziae 1100g, Polygonum multiflower knotweed 1200g, grass-leaved sweetflag 1200g, mulberries 1200g, put it in 10 times of water gagings and soak.Drop into multi-function extractor and extract twice, first time adds 8-10 times amount soak by water 1-2 hour, and second time adds 4-8 times amount soak by water 1-2 hour, merges twice decocting liquid, filters to get filtrate; Heating is concentrated into powder, and then put into baking oven inner drying powdered, sealwort good with frying after ultraviolet radiation for sterilizing and disinfecting is hybrid packed, and during use, direct boiling water is taken after mixing it with water.

Specific embodiment 4:

Get sealwort 3500g to clean, get the sealwort obtained and clean, the airing time, at 7-12 hour, parches, be cut into thin slice, put water proof in pot and steam 30-60 minute at 80-100 DEG C, then dry, repeat again after drying to steam once, dry, then take after mixing it with water to steam and shine once, then put into large iron pan to stir-fry, on first backward downwards, firmly want evenly, when sealwort color starts blackout, start little fire stir-fry 30-45 minute shaping, when color becomes pitchy, naturally dry after taking out, by surplus stock fructus alpiniae oxyphyllae 1200g, polygala root 1200g, cultivated land 1200g, Radix Angelicae Sinensis 1100g, root tuber of aromatic turmeric 1100g, Psoralea corylifolia 1200g, fushen 1200g, walnut kernel 1200g, Radix Codonopsis 1100g, seed of Oriental arborvitae 1200g, Radix Astragali 1200g, RADIX POLYGONI MULTIFLORI PREPARATA 1200g, root of herbaceous peony 1200g, fruit of Chinese magnoliavine 1200g, bighead atractylodes rhizome 1200g, Flos Albiziae 1100g, Polygonum multiflower knotweed 1200g, grass-leaved sweetflag 1100g, mulberries 1200g, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use, become component 1, again the dregs of a decoction that alcohol extract is crossed are put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, and 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating be concentrated into paste, stand for standby use, become component 2, merge component 1 and component 2 paste making agent, merge the sealwort fried, pack.

Pharmacological toxicity is tested

Experimental example 1: acute toxicity test of the present invention

One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/ml.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mouse maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mouse 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximal tolerance dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give the present invention by the disposable gavage of small white mouse, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicinal powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicinal powder dosage is > 42g/kg. day (every g medicinal powder is equivalent to 10g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with control group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safe range of the present invention is comparatively large, is a kind of safe and reliable health products.

Pharmacological experiment:

Cause the continuous gavage of learning memory disorder model mice with saponins of rhizoma polygonati (PTS) to scopolamine, result display PTS obviously can improve the learning and memory function of model mice under 400mg/kg dosage.Huang Fang etc. are with Siberian solomonseal rhizome polysaccharide 200, 100, 50mg/kg3 dosage (is hydergene as positive control to respectively the continuous gavage 15d. of old rats, negative control is equivalent distilled water), within after administration the 15th day and the 30th day, carry out learning test with y type labyrinth, result shows that Siberian solomonseal rhizome polysaccharide significantly can improve old rats learning and memory and memory reproduction, reduce errors number (compared with positive control, Siberian solomonseal rhizome polysaccharide 200mg/kg and 100mg/kg dosage group difference are all extremely significantly (P < 0.01), 50mg/kg dosage group significant difference (P < 0.05) to vascular dementia rat models with every 100g body weight 0.5ml gavage 1 week, then continue medication 1.5 months and 2.5 months (naturally taking drink) with 10% Siberian solomonseal rhizome health-care tea, result shows that Siberian solomonseal rhizome health-care tea has and reinvents synaptic structure and function, improve the effect of vascular dementia SD female rats ability of learning and memory.

Clinical testing:

1 data and method

1.1 case selections by single random pair grouping in even-numbered days, adopt mono blind method to the vascular dementia of being in hospital (hereinafter referred to as VD) patient 120 example.

Treatment group 60 example, wherein man 37 example, female 23 example.Minimum 47 years old of age, maximum 83 years old, 63.52 years old mean age.Mild dementia 37 example, moderate 17 example, severe 6 example.

Control group 60 example, wherein man 36 example, female 24 example, minimum 46 years old of age, maximum 82 years old, 62.95 years old mean age.Mild dementia 39 example, moderate 15 example, severe 6 example.Two groups of diagnostic criteria all meeting the vascular dementia that " International Classification of Disease 10th edition diagnostic criteria " (CIM10) and NINDS mono-AIREN1993 work out.Through statistical procedures there was no significant difference in age, sex, mini mental state examination (MMSE) integration, daily living measuring scale (ALD) integration.

1.2 methods for the treatment of control groups: add CDPC 1g, vitamin C 3g with physiological saline 250ml; Mulberry 20ml in 5% glucose 25Oml (diabetic's physiological saline), quiet, every day 1 time.Placebo homotype capsule 4, oral, every day 3 times, altogether 21d.Oral Nimodipine, vitamin E simultaneously.

Treatment group: use sealwort galangal fruit health-care tea of the present invention, Fang Yong: sealwort 35g, fructus alpiniae oxyphyllae 10g, polygala root 12g, cultivated land 13g, Radix Angelicae Sinensis 12g, root tuber of aromatic turmeric 10g, Psoralea corylifolia 10g, fushen 10g, walnut kernel 10g, Radix Codonopsis 11g, seed of Oriental arborvitae 10g, Radix Astragali 10g, RADIX POLYGONI MULTIFLORI PREPARATA 11g, root of herbaceous peony 12g, fruit of Chinese magnoliavine 12g, bighead atractylodes rhizome 11g, Flos Albiziae 12g, Polygonum multiflower knotweed 12g, grass-leaved sweetflag 11g, mulberries 10g, make tea-drinking bag, oral, every day 3 times, altogether 21d.

1.3 efficacy determination two groups treatment front and back and group ask that MMSE, ADL integration carries out statistical analysis and compares.Effective: subjective symptoms obviously alleviates or disappears, MMSE integration improves 5 points or normally close, and ADL integration declines more than 10 points or normally close.

Effective: partial symptoms alleviates, MMSE integration improves more than 3 points, and ADL integration declines more than 5 points.

Invalid: symptom is unchanged, MMSE integration improves not as good as 3 points, and ADL integration declines not as good as 5 points.

Worsen: aggravation, MMSE integration declines more than 3 points, and ADL integration improves more than 5 points.

2 results

Before and after 2.1 Different Culture degree treatments, the change of MMSE integration is in table 1.

MMSE integral contrast (X ± S) before and after the treatment of table 1 Different Culture degree

Treatment group is better than control group, has significant difference (* P < 0.05, * * P < 0.01).

More than treatment group middle and primary schools be better than illiteracy's group (P < 0.05).

Before and after 2.2 different sexes treatments, the change of ADL integration is in table 2.

ADL integral contrast (X ± S) before and after the treatment of table 2 different sexes

Treatment group is better than control group, has significant difference (* P < 0.05, * * P < 0.01).

In treatment group, the male sex is better than women, has significant difference (P < 0.05).

After 2.3 age groups treatments, general curative effect compares in table 3.

After the treatment of table 3 age groups, general curative effect compares

Compare with age group obvious effective rate, treatment group is better than control group, has significant difference (P < 0.05); In treatment group, obvious effective rate compares, and within less than 60 years old, group is better than more than 61 years old group, has significant difference (P < 0.05); Total effective rate compares, and treatment group is better than control group (P < 0.05).

3 discuss

VD is due to ischemic or hemorrhagic cerebrovascular disease and full brain ischemic, anoxic and the dementia based on cognition dysfunction that causes.Along with the cerebrovascular incidence of disease raises and China's population aging, the incidence of disease of VD has ascendant trend year by year.How to stop the development of VD, this be at present, even from now on doctor need study emphasis problem.

Theory of traditional Chinese medical science is thought: VD disease is positioned at brain, with liver, the heart, spleen, substantial connection of having suffered from a deficiency of the kidney, its interpretation of the cause, onset and process of an illness is short mainly due to kidney essense, brain is not filled, the turbid resistance of extravasated blood phlegm close brain steal, brains lose in moisten support caused by. this research based on theory of traditional Chinese medical science, in conjunction with the modern medicine cause of disease, the interpretation of the cause, onset and process of an illness, development sealwort, grass-leaved sweetflag, polygala root etc. 10 taste Chinese medicine composition galangal fruit health-care tea, there is tonifying kidney and benefiting sperm, reduce phlegm out steal, the effect of brain-nourishing intelligence-benefiting, invigorating blood circulation addiction.

Say there is anti-ischemic, anoxic brain damage and improve cognitive function from modern medical theory.VD mainly causes and the brain tissue structural deterioration remembered, intelligence is relevant due to cerebrovascular factor, causes the neurotransmitter Ach relevant with memory to reduce, and oxygen radical, excitatory amino acid, calcium overload also play certain effect in the generation of VD and progress in addition.

Sealwort galangal fruit health-care tea may contain neurotrophic factor sample ingredient, vascular factor can be promoted to cause with the reparation of memory about destroying brain tissue, make neurotransmitter Ach secretion increase.Improve SOD active, reduce excitatory amino acid, content of oxygen free radical in brain tissue, suppress the activation of cerebral cortex excitatory amino acid receptor, play nourishing brain cell, protect brain cell, improve brain function, improve cognitive ability.As shown in Table 1: treatment group is better than control group, there is significant difference (P < 0.05), and find that the improvement of cognitive function is relevant with the schooling of VD patient, little weak effect of learning to read and write, there is statistical significance (P < 0.05), may be less with little nerve synapse of learning to read and write, poor to the sensitiveness of medicine, neurotransmitter secretion, the recovery of propagation function may need the time more grown.

Cerebral hypoxia ischemia is many to be caused due to brain blood circulatory disorder, therefore invigorating blood circulation trace, improving brain blood circulation is a kind of important measures correcting cerebral ischemia, anoxic.Foster encephaloclastic chain reaction is lacked to delay ischemic, thus protection brain cell.Brain-nourishing intelligence-benefiting capsule contains Brain circlulation promoter sample ingredient, by invigorating blood circulation small house, improves brain blood circulation, promotes that brain function is recovered, improves the defect of nervous function, improve activity of daily living.As shown in Table 2, treatment group is better than control group, has significant difference (p < 0.05).And the treatment group male sex is better than women, there is significant difference (p < 0.05).Women's group effect is seen, may be ill easily sentimental with women, is bad at mental activity and physical exertion is relevant, also may women relevant not as good as male sex's sensitivity to brain blood circulation promoter sample substance reaction.

Sealwort galangal fruit health-care tea can improve the cognitive ability of VD, improves activity of daily living, for family and society alleviate burden.This research of side effect does not find any bad reaction in whole therapeutic process.None example occurs to worsen or death.Electrocardiogram, liver function, kidney merit treatment before and after look Comparative result not statistically significant.

Claims (6)

1. the Siberian solomonseal rhizome health-care tea of a supplemental treatment vascular dementia, it is characterized in that, the Chinese medicine material of described Siberian solomonseal rhizome health-care tea is made up of the bulk drug of following parts by weight: sealwort 10 ~ 50 parts, fructus alpiniae oxyphyllae 10 ~ 20 parts, polygala root 10 ~ 20 parts, 10 ~ 20 parts, cultivated land, Radix Angelicae Sinensis 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, Psoralea corylifolia 10 ~ 20 parts, fushen 10 ~ 20 parts, walnut kernel 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, the seed of Oriental arborvitae 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, the root of herbaceous peony 10 ~ 20 parts, 10 ~ 20 parts, the fruit of Chinese magnoliavine, the bighead atractylodes rhizome 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Polygonum multiflower knotweed 10 ~ 20 parts, grass-leaved sweetflag 10 ~ 20 parts, mulberries 10 ~ 20 parts.

2. the Siberian solomonseal rhizome health-care tea of supplemental treatment vascular dementia according to claim 1, it is characterized in that, the Chinese medicine material of described Siberian solomonseal rhizome health-care tea is made up of the bulk drug of following parts by weight: sealwort 10 ~ 30 parts, fructus alpiniae oxyphyllae 10 ~ 15 parts, polygala root 10 ~ 15 parts, 10 ~ 15 parts, cultivated land, Radix Angelicae Sinensis 10 ~ 15 parts, root tuber of aromatic turmeric 10 ~ 15 parts, Psoralea corylifolia 10 ~ 15 parts, fushen 10 ~ 15 parts, walnut kernel 10 ~ 15 parts, Radix Codonopsis 10 ~ 15 parts, the seed of Oriental arborvitae 10 ~ 15 parts, the Radix Astragali 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, the root of herbaceous peony 10 ~ 20 parts, 10 ~ 20 parts, the fruit of Chinese magnoliavine, the bighead atractylodes rhizome 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Polygonum multiflower knotweed 10 ~ 20 parts, grass-leaved sweetflag 10 ~ 20 parts, mulberries 10 ~ 20 parts.

3. the Siberian solomonseal rhizome health-care tea of supplemental treatment vascular dementia according to claim 1, it is characterized in that, the Chinese medicine material of described Siberian solomonseal rhizome health-care tea is made up of the bulk drug of following parts by weight: sealwort 10 ~ 40 parts, fructus alpiniae oxyphyllae 10 ~ 20 parts, polygala root 10 ~ 20 parts, 10 ~ 20 parts, cultivated land, Radix Angelicae Sinensis 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, Psoralea corylifolia 10 ~ 20 parts, fushen 10 ~ 20 parts, walnut kernel 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, the seed of Oriental arborvitae 10 ~ 20 parts, the Radix Astragali 10 ~ 15 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 15 parts, the root of herbaceous peony 10 ~ 15 parts, 10 ~ 15 parts, the fruit of Chinese magnoliavine, the bighead atractylodes rhizome 10 ~ 15 parts, Flos Albiziae 10 ~ 15 parts, Polygonum multiflower knotweed 10 ~ 15 parts, grass-leaved sweetflag 10 ~ 15 parts, mulberries 10 ~ 15 parts.

4. the preparation method of the Siberian solomonseal rhizome health-care tea of supplemental treatment vascular dementia as described in any one of claims 1 to 3 item, it is characterized in that, the preparation process of described Siberian solomonseal rhizome health-care tea comprises following aspect:

A. the preparation of sealwort;

B. described other raw materials pulverized, soak, heating, refluxing extraction 2 times;

C. again the concentration of liquid medicine that other raw materials extract is become granule, pulvis or paste;

D. concentrated granule, pulvis or paste are mixed with the sealwort prepared, be prepared into health protection tea.

5. the preparation method of the Siberian solomonseal rhizome health-care tea of supplemental treatment vascular dementia according to claim 4, it is characterized in that, in described step a, cleaned by the sealwort of results, the airing time, at 7-12 hour, parches; Be cut into thin slice, put water proof in pot and steam 30-60 minute at 80-100 DEG C, then dry; Repeat again after drying to steam once, dry; Repeat again to steam and shine once; Then put into large iron pan to stir-fry, on first backward downwards, firmly want evenly, when sealwort color starts blackout, start little fire stir-fry 30-45 minute shaping; When color becomes pitchy, naturally dry after taking out.

6. the preparation method of the Siberian solomonseal rhizome health-care tea of supplemental treatment vascular dementia according to claim 4, it is characterized in that, in described step c, the filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, convection drying powdered.