CN101269174A - Pharmaceutical composition for improving memory disturbance senile dementia and preparation method thereof - Google Patents
Pharmaceutical composition for improving memory disturbance senile dementia and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a drug, in particular to a drug composition for improving dysmnesia alzheimer disease and a preparation method thereof. The drug composition of the invention is made of the following raw medicines according to the parts by weight of 90 grams of gymnadenia conopsea, 90 grams of radix polygoni multiflori preparata, 90 grams of acanthopanax, 90 grams of sealwort, 90 grams of milk veteh, 60 grams of angelica, 60 grams of medlar, 60 grams of shizandra berry, 60 grams of dogwood, 60 grams of polygala, 60 grams of grassleaf sweelflag rhizome, and 60 grams of red paeonia. The drug composition of the invention is made of fully natural Tibetan pharmaceuticals with high quality and without pollution and traditional Chinese medicines which are mixed reasonably and does not have any side effect. The drug composition for improving dysmnesia alzheimer disease is widely applied to school students younger than eighteen years old and the middle and old-aged brainworkers elder than 45 years old to take as well as the symptoms of feeblemindedness, dysmnesia and alzheimer disease, etc.
Description
Technical field
The present invention relates to a kind of medicine, specifically relate to a kind of pharmaceutical composition that improves memory disturbance senile dementia and preparation method thereof.
Background technology
National development depends on the raising of whole people's quality with prosperous and powerful.The brain potential of developing everyone is the important step that realizes this ambitious goal.In recent years, the sickness rate of encephalopathy improves day by day.And become one of important topic of contemporary world medical research.The problem of an aging population in the world has become the key subjects that the various countries scientist is paid close attention in addition.In recent years, the sickness rate of encephalopathy improves clinically day by day, and has become the important topic of world today's medical research.According to statistics, there are about 5,000 ten thousand people of various encephalopathy patients in China, and this numeral is increasing year by year.This type of patient is not only painful in person, perplexs family simultaneously, has a strong impact on the population quality of country and patient's self quality of life.
Brain is one of most important structure of human body, and for the existing long history of structure, function understanding and the research of brain, but the treatment of encephalopathy lags behind the development of diagnosis greatly.The nervus centralis impaired development that western medicine causes various internal and external reasonses and become the impaired encephalopathy that causes because of the nervus centralis degeneration causes, and the treatment that chromosomal disorders change the brain function abnormal development that causes etc. does not still have good solution.Because brain cell does not have regeneration capacity, treating the encephalopathy process so is the process that promotes neuronal development and repairing damage neurocyte, also promptly transfers the potential process of brain.China medical sci-tech worker seeks multipath Therapeutic Method for this reason, the health medicine of relevant Fructus Alpiniae Oxyphyllae is as " No. one, life ", " melatonin ", " ANSHEN BUNAO YE " etc. in the market, be improving memory, strengthen the human quality aspect and played important role.But in conjunction with being used for the treatment of dysmnesia and retarded, forgetful, absent minded, the medicine of diseases such as alzheimer disease yet there are no record with middle Tibetan medicine.
Summary of the invention
The technical problem to be solved in the present invention is at the deficiencies in the prior art, provide a kind of use for reference the Chinese, Tibetan medicine and pharmacology culture elite with middle Tibetan medicine in conjunction with as a kind of pharmaceutical composition that improves memory disturbance senile dementia and preparation method thereof.
A kind of pharmaceutical composition that improves memory disturbance senile dementia of the present invention and preparation method thereof is achieved by following technical proposals: pharmaceutical composition of the present invention is made by the following weight percent crude drug:
Rhizoma Gymnadeniae (prosperous drawing) 90g Radix Polygoni Multiflori Preparata 90g Radix Et Caulis Acanthopanacis Senticosi 90g Rhizoma Polygonati (La Nie) the 90g Radix Astragali (Sa Sai) 90g Radix Angelicae Sinensis (when more) 60g Fructus Lycii (other rice is plucked me) 60g Fructus Schisandrae Chinensis (reaching true) 60g Fructus Corni 60g Radix Polygalae 60g Rhizoma Acori Graminei (Xu Da) 60g Radix Paeoniae Rubra (drawing the bean agate to protect) 60g.
Described preparation method is:
1), getting the 12 flavor medical materials that meet the raw medicinal material quality standard cleans, remove impurity, cleans, dries, sterilizes.
2), Rhizoma Gymnadeniae, Radix Angelicae Sinensis, Rhizoma Acori Graminei are ground into coarse powder, sieving for standby.
3), nine flavor medical materials such as Radix Polygoni Multiflori Preparata, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Polygonati decoct with water secondary, 3 hours for the first time, 2.5 hours for the second time, collecting decoction filtered, filtrate is condensed into the extractum shape.
4), extractum and above-mentioned medicinal material coarse powder add the appropriate amount of auxiliary materials mix homogeneously, drying is ground into fine powder, fill becomes 1000 of the capsules of every dress 0.3g, packing is promptly.
A kind of pharmaceutical composition that improves memory disturbance senile dementia of the present invention and preparation method thereof has following beneficial effect compared with prior art: pharmaceutical composition of the present invention selects for use high-quality, pure natural, free of contamination pure Tibetan medicine and Chinese medicine reasonable compatibility to be prepared from, and has no side effect.Rhizoma Gymnadeniae different name Rhizoma Gymnadeniae of the present invention, Fructus Citri Sarcodactylis ginseng, palm ginseng, hands ginseng, Tibetan medicine name Wang La.Rhizoma Gymnadeniae strong, the strong essence of can steeping in wine, " blood yiqi, promoting the production of body fluid to quench thirst ", " it is relieving convulsion to calm the nerves for strengthening by means of tonics, spleen reinforcing lung moistening, the QI invigorating pain relieving.Training the body body weakness, the neurasthenia ... ".Rhizoma Gymnadeniae is joined Rhizoma Polygonati, Radix Codonopsis can effectively be treated diseases such as weak after being ill god declines, sexual impotence, chronic diarrhea.Prosperous Sha, Niemi, Ji Lehao (the Rhizoma Gymnadeniae recuperating depleted YANG ball of drawing of Tibetan medicine's proved recipe, " Jilin Province's drug standard " 1997 editions) preparation Rhizoma Gymnadeniae recuperating depleted YANG ball, with the Rhizoma Gymnadeniae is the gas of the big spleen reinforcing kidney of principal agent, ten pleasant impression medicines such as 5 Cordyceps, Rhizoma Polygonati, Fructus Alpiniae Oxyphyllae treatment kidney spleen deficiency, diseases such as seminal emission lumbago, pipe abdomen fullness, inappetence.In addition, it all is principal agent with the Rhizoma Gymnadeniae that centre ancestor's " Sanbao " health liquor (" a surname of Qinghai Province medicine standard " enlarged edition in 1997), Mulberry lattice are handed over (the kidney invigorating ball, " Ministry of Public Health a surname medicine standard ") etc., tonifies Qi of the kidney, the spermatogenesis lung moistening.Principal agent in the Radix Polygoni Multiflori side of being, " book on Chinese herbal medicine justice " record: " Radix Polygoni Multiflori is specially gone into Liver and kidney, takes a tonic or nourishing food to build up one's health Kidney-Yin; and flavor is solid very thick, and it is pained to hold concurrently slightly, property is then gentle; all the reason with part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels envelope Tibetans meets; so can fill out beneficial vital essence, have the flat secret effect of negative and positive ", " book on Chinese herbal medicine is looked for the truth " record: " Radix Polygoni Multiflori goes into to lead in liver; be the yang aspect of yin medicine; thus specially go into the usefulness that Liver Channel thinks that beneficial blood dispels the wind, its double the kidney invigorating person, also holding concurrently because of tonifying liver reaches also.One is the congenital Kidney-Yin medicine of high benefit, rescues the strong danger of lonely yang hyperactivity so its merit can be stood; One is to transfer the need of mending the nutrient blood day after tomorrow, thinks informal dress, and long foster spirit gets rid of illness and transfers the bait of unit ", " Kaibao Bencao " record: " beneficial vim and vigour, black moustache hair on the neck, improving healthy complexion, the long muscles and bones of clothes of a specified duration, beneficial marrow, it is not old to prolong life ".Modern pharmacological research proves that Radix Polygoni Multiflori can make superoxide dismutase (SOD) content increase in the mice body, impels adrenal weight to increase, and has anti-senescence functions such as the blood of falling ester, the kidney invigorating and human body immunity improving.Radix Et Caulis Acanthopanacis Senticosi is gone into liver, kidney two warps, the effect of tool strengthening the body resistance, function wind-damp dispelling, strengthening bone and muscle, blood circulation promoting and blood stasis dispelling, all dialectical genus deficiency syndrome persons are many can to use, " Mingyi Bielu " record: " treat the empty win of the five internal organs, the invigorating middle warmer benefit is smart; strengthening bone and muscle; strong will ", " book on Chinese herbal medicine is new again " record: " eliminating phlegm and removing dampness, foster kidney benefit is smart ".Radix Et Caulis Acanthopanacis Senticosi has than Radix Ginseng and better adapts to the former state effect, can make human body be in " strengthening the nonspecific defense capability state ".Experiment showed, under the dosage of Radix Et Caulis Acanthopanacis Senticosi nonspecific resistance in increasing body, to normal function and do not make significant difference; And resistance reduces in vivo, or when running into added burden special requirement being arranged, can increase the function of muscle power or intellectual activity on the contrary.Rhizoma Gymnadeniae in the side, Radix Polygoni Multiflori and Radix Et Caulis Acanthopanacis Senticosi constitute principal agent, present the merit that powerful nourishing the liver and kidney, beneficial essence add marrow, brain.
Be aided with yin, yang, gas, the blood that Rhizoma Polygonati, Fructus Lycii, the Radix Astragali and Radix Angelicae Sinensis make the people and all mend, strengthening the body resistance, the merit performance of devote every effort to help principal agent." brilliant pearl book on Chinese herbal medicine " record, the Rhizoma Polygonati Tibetan medicine is by name to draw Nie, sweet in the mouth, bitterness, the energy heat clearing away, nourishing: sweet, flat, cold relieving is moistened cardiopulmonary, mends marrow, is good for the stomach; Control local edema, the lumbago and skelalgia that cold-damp causes, pruritus is lost with oozing out in dermatosis and the marrow, languishment, diseases such as nutritional edema also have anti-ageing effect.Boosting qi and nourishing yin, spleen invigorating, lung moistening kidney tonifying, " Japan hanako materia medica " record: " mend five kinds of strain and seven kinds of impairment; help muscles and bones ... strengthening the spleen stomach, profit cardiopulmonary ", " the southern regions of the Yunnan Province book on Chinese herbal medicine " record: " tonify deficiency adds essence ", " book on Chinese herbal medicine meets former " record: " the alleviating distention in middle-JIAO QI invigorating makes five to hide mediation, muscle sufficiency; bone marrow is hard by force, all is the merit of nourishing YIN ".Pharmacological research confirms that Rhizoma Polygonati has obvious prolongation silkworm larva life-span phase effect, illustrates its tool anti-aging effects.Zhang Hua " natural science will " puts down in writing cloud: " day say always, the grass of the sun is said Rhizoma Polygonati, and bait and eat it can be long-living ".Fructus Lycii nourishing kidney lung moistening, tonifying liver make eye bright, but both essence and bloods of nourishing the liver and kidney, but the kidney warming the yang aspect of yang gas again." book on Chinese herbal medicine is just ": " Fructus Lycii, highly seasoned and pure, so can nourishing YIN, sun is arranged, so can QI invigorating in the moon ", " Bencao Jingshu ": " moisten and nourish, double can bringing down a fever, and specially in the kidney invigorating, lung moistening, promote the production of body fluid, QI invigorating, be the key medicine of Liver and kidney kidney-YIN being deficient, the tonification of consumptive disease interior-heat ".Radix Astragali invigorating the spleen and replenishing QI, " Mingyi Bielu ": " it is deficient to mend the husband, and five kinds of over strain is won thin ", " book on Chinese herbal medicine is looked for the truth ": " Radix Astragali is gone into the lung QI invigorating, goes into that table is real to be defended, for all medicines of QI invigorating, be so that the title of over sixty years of age to be arranged ".Chinese angelica blood supplementing is invigorated blood circulation, " Japan hanako materia medica ": " control a wind cutting, all blood; mend all labor, broken stagnant blood is supported fresh blood and primary symptom addiction ", become endlessly " Treatise on Febrile Disease with Notes ": " the arteries and veins person house of blood, all blood all belongs to the heart, all persons of promoting blood circulation must first reinforcing the heart benefit blood; so Zhang Zhongjing ... with the hardship temperature of Radix Angelicae Sinensis to help painstaking effort ", " book on Chinese herbal medicine is just ": " its sweet in the mouth of Radix Angelicae Sinensis and weigh is so specially can enrich blood; its gas gently and suffering, so the dual intensity promoting the circulation of blood, invigorating middle warmer has; in going benefit is arranged, the gas medicine in the sincere blood, also the panacea in the blood is also ".In addition, astringent or styptic treatment for spontaneous sweating with the convergence of Fructus Schisandrae Chinensis, Fructus Corni, the merit of row the liver and the kidney tonifying mind calming.The Fructus Schisandrae Chinensis kidney calming, supplementing QI for promoting the production of body fluid is restrained astringent or styptic treatment for spontaneous sweatingly, and " herbal classic ": " it is thin that impairment caused by overstrain is won, tonifying for the deficiency, reinforcing YIN-essence, beneficial man's essence for QI invigorating, cough with dyspnea ", " book on Chinese herbal medicine converge speech ": " medicine that Fructus Schisandrae Chinensis, astringing QI promote the production of body fluid is also.So go into lung last, be lowered to kidney, go into the benefit that lung has the Jiyuan of promoting the production of body fluid, going into kidney has controlling nocturnal emission with astringent drugs to support the merit of marrow ", Compendium of Material Medica: " trimethyl gallic acid is salty goes into liver and the kidney invigorating, and hot bitter in taste acting on the heart and tonifying the lung are sweetly gone into Middle Palace strengthening the spleen stomach ".Fructus Corni liver and kidney tonifying, arresting seminal emission are astringent or styptic treatment for spontaneous sweating, " property of medicine opinion ": " control headache ... the kidney invigorating gas, Xing Yangdao adds marrow ", " Bencao Jingshu ": " temperature and main the benefit, sour in the mouth and main holding back are so vital essence benefit and the moon are by force also.Lean then the five internal organs is pacified the nine orifices diarrhea certainly ".Jiao establishes one's virtue " medication gains in depth of comprehension ten are said ": " Fructus Schisandrae Chinensis is relatively astringed the lung through dissipation gas wild, receives the Yuanyang of kidney dissipation desire mistake; Fructus Corni is partial to the moon of nourish liver and kidney, yin fluid astringing sun antiperspirant wild ".
Assistant is with Radix Polygalae, Rhizoma Acori Graminei tranquilizing the mind, and hypermnesia is had one's ideas straightened out.The Radix Polygalae tranquilizing the mind, strong will benefit is smart, controls forgetful, " herbal classic ": " tonifying for the deficiency removes pathogen, sharp nine orifices; Fructus Alpiniae Oxyphyllae is intelligent, normal hearing and eyesight is not forgotten; strong will times power ", " Mingyi Bielu ": " centering gas, spasmolytic is throbbed with fear; benefit is smart ", " book on Chinese herbal medicine justice ": " flavor bitter in taste acting on the heart, temperature promoting the circulation of blood; and fragrance is clear, edema caused by disorder of QI can pass through again.Its special main heart channel person, the aggregation of this blood of the heart, Xin Wen with tonneau it, should its heart-yang of bestirring oneself, and benefit is gone into wisdom ".The Rhizoma Acori Graminei refreshment of having one's ideas straightened out, " Mingyi Bielu ": " audition improvement order, beneficial intelligence ", Wang Bingheng " Chongqing hall random notes ": " Rhizoma Acori Graminei, comfortable gas, the smooth mind, happy mood, beneficial heart person, panacea is also.Removing summer-heat medicinal it, the dirty turbid and city wall that eliminates the phlegm of relying; Nourish medicinal it, the knot of a surname's thought of borrowing and being proficient in the law of natural movement ".Experimentation, the contained beta-Asarone of Rhizoma Acori Graminei truly has certain curative effect to various disturbance of consciousnesss such as respiratory failure, drowsiness, stupor and Mental Subnormality symptom, this and this medical instrument inducing resuscitation cognitive consonance of traditional medicine.
Make with Radix Paeoniae Rubra clearing away heat and cooling blood, eliminating stasis to stop pain " Mingyi Bielu ": " clear and coherent blood vessels, slow in; dispelling malignant blood; expelling extravasated blood, gas anhydrates ", " Bencao Jingshu ": " then cold and heat are from ending for its main arthralgia due to stagnation of blood of removing; broken hard long-pending person; blood stasis is then had a fever, promoting the circulation of blood, and arthralgia due to stagnation of blood hernia abdominal mass all blood clotting stagnates and forms; the broken blood that stagnates, then numbness and and the hernia abdominal mass from disappearing ".
In sum, all medicines in the side of being or YIN nourishing or invigorating the liver and kidney or replenishing QI and blood or profit cardiopulmonary or spleen invigorating kidney, collect and keep fit nourishing and the product of consciousness-restoring and orifice-opening in a side, the merit that He Zou nourishing the liver and kidney, beneficial essence are added marrow, brain, cure mainly because of deficiency of the liver and kindey, essence and blood lose all diseases due to void etc., obvious with all brain disease effects especially.
Compound recipe Rhizoma Gymnadeniae Cognex of the present invention is used for reference Chinese Tibetan medicine and pharmacology culture elite just, is fully studied on the document basis of the relevant treatment of motherland's traditional medicine disease of brain, and repeated screening develops.
A kind of pharmaceutical composition that improves memory disturbance senile dementia of the present invention and preparation method thereof is through curing mainly relevant pharmacodynamics test, acute toxicity test, long term toxicity test and clinical pharmacology, toxicological test with function, and its conclusion is as follows:
(1) Fructus Alpiniae Oxyphyllae test: show that by result of the test compound recipe Rhizoma Gymnadeniae Cognex obtains memory to the experimental model of multiple animal, memory represents, memory is consolidated three phases and is all improved significantly.
(2) anti-stress ability test
1) has tangible oxygen lack resistant function;
2) has the obvious anti-fatigue effect.
Three, toxicology test:
(1), acute toxicity test:
Compound recipe Rhizoma Gymnadeniae Cognex LD
50Survey, oral maximum agent dosis tolerata is equivalent to be grown up and intends 280 times of day clothes dosage greater than 50.4g/kg, is not found to the overt toxicity reaction.
(2), long term toxicity test:
Compound recipe Rhizoma Gymnadeniae Cognex 2.4g/kg, 1.2g/kg (be equivalent to respectively clinical plan day clothes dosage 100 times, 50 times), give rat gavage 45 days continuously, 90 days, the general behavior of animal is movable normal, rat body weight growth childhood there is not obviously influence, 24 hours feed consumptions of rat there is not the overt toxicity influence, rat blood is learned, the organ coefficient that blood is given birth to and main organs does not have the overt toxicity influence, show and heavy dose, the long course of treatment took compound recipe Rhizoma Gymnadeniae Cognex 45 days, 90 days, tangible toxic reaction does not appear in rat, and clinical use can be provided.
A kind of pharmaceutical composition that improves memory disturbance senile dementia of the present invention can be widely used in the under-18s students in middle and primary schools, and 18-45 year, above person in middle and old age brain worker took, and also was applicable to diseases such as retarded, dysmnesia, alzheimer disease.
The specific embodiment
Below in conjunction with embodiment a kind of pharmaceutical composition that improves memory disturbance senile dementia of the present invention and preparation method thereof is further described.
A kind of pharmaceutical composition that improves memory disturbance senile dementia of the present invention is made by the following weight percent crude drug:
Embodiment 1.
Rhizoma Gymnadeniae (prosperous drawing) 90g Radix Polygoni Multiflori Preparata 90g Radix Et Caulis Acanthopanacis Senticosi 90g Rhizoma Polygonati (La Nie) the 90g Radix Astragali (Sa Sai) 90g Radix Angelicae Sinensis (when more) 60g Fructus Lycii (other rice is plucked me) 60g Fructus Schisandrae Chinensis (reaching true) 60g Fructus Corni 60g Radix Polygalae 60g Rhizoma Acori Graminei (Xu Da) 60g Radix Paeoniae Rubra (drawing the bean agate to protect) 60g.
Described preparation method is:
1), getting the 12 flavor medical materials that meet the raw medicinal material quality standard cleans, remove impurity, cleans, dries, sterilizes.
2), Rhizoma Gymnadeniae, Radix Angelicae Sinensis, Rhizoma Acori Graminei are ground into coarse powder, sieving for standby.
3), nine flavor medical materials such as Radix Polygoni Multiflori Preparata, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Polygonati decoct with water secondary, 3 hours for the first time, 2.5 hours for the second time, collecting decoction filtered, filtrate is condensed into the extractum shape.
4), extractum and above-mentioned medicinal material coarse powder add the appropriate amount of auxiliary materials mix homogeneously, drying, described baking temperature is 55-60 ℃, is ground into fine powder, fill becomes 1000 of the capsules of every dress 0.3g, packing promptly.
Claims (3)
1, a kind of pharmaceutical composition that improves memory disturbance senile dementia, it is characterized in that: described pharmaceutical composition is made by the following weight percent crude drug:
Rhizoma Gymnadeniae 90g Radix Polygoni Multiflori Preparata 90g Radix Et Caulis Acanthopanacis Senticosi 90g Rhizoma Polygonati 90g Radix Astragali 90g
Radix Angelicae Sinensis 60g Fructus Lycii 60g Fructus Schisandrae Chinensis 60g Fructus Corni 60g Radix Polygalae 60g
Rhizoma Acori Graminei 60g Radix Paeoniae Rubra 60g.
2, the preparation of drug combination method of improving memory disturbance senile dementia as claimed in claim 1 is characterized in that described preparation method is:
1), getting the 12 flavor medical materials that meet the raw medicinal material quality standard cleans, remove impurity, cleans, dries, sterilizes.
2), Rhizoma Gymnadeniae, Radix Angelicae Sinensis, Rhizoma Acori Graminei are ground into coarse powder, sieving for standby.
3), nine flavor medical materials such as Radix Polygoni Multiflori Preparata, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Polygonati decoct with water secondary, 3 hours for the first time, 2.5 hours for the second time, collecting decoction filtered, filtrate is condensed into the extractum shape.
4), extractum and above-mentioned medicinal material coarse powder add the appropriate amount of auxiliary materials mix homogeneously, drying is ground into fine powder, fill becomes 1000 of the capsules of every dress 0.3g, packing is promptly.
3, the preparation of drug combination method of improving memory disturbance senile dementia as claimed in claim 2, it is characterized in that: described baking temperature is 55-60 ℃.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810656A (en) * | 2010-04-27 | 2010-08-25 | 哈尔滨珍宝制药有限公司 | Siberian ginseng extract and medicine combination thereof |
| CN102247537A (en) * | 2011-08-12 | 2011-11-23 | 刘立甫 | Chinese herbal medicine compound preparation capable of strengthening brain, benefiting intelligence and improving memory |
| CN103127382A (en) * | 2013-02-22 | 2013-06-05 | 广西迪泰制药有限公司 | Preparation method of traditional Chinese medicine preparation |
| CN103719493A (en) * | 2013-12-31 | 2014-04-16 | 青岛恒波仪器有限公司 | Brain-boosting and intelligence-enhancing sealwort health-care tea and preparation method thereof |
| CN105663965A (en) * | 2016-03-01 | 2016-06-15 | 杜延梅 | Intelligence-improvement prescription |
| CN106492038A (en) * | 2016-12-13 | 2017-03-15 | 蓝庆流 | A kind of Chinese medicine composition for strengthening memory |
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2008
- 2008-04-24 CN CNA2008100443080A patent/CN101269174A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810656A (en) * | 2010-04-27 | 2010-08-25 | 哈尔滨珍宝制药有限公司 | Siberian ginseng extract and medicine combination thereof |
| CN102247537A (en) * | 2011-08-12 | 2011-11-23 | 刘立甫 | Chinese herbal medicine compound preparation capable of strengthening brain, benefiting intelligence and improving memory |
| CN102247537B (en) * | 2011-08-12 | 2013-02-13 | 刘立甫 | Chinese herbal medicine compound preparation capable of strengthening brain, benefiting intelligence and improving memory |
| CN103127382A (en) * | 2013-02-22 | 2013-06-05 | 广西迪泰制药有限公司 | Preparation method of traditional Chinese medicine preparation |
| CN103719493A (en) * | 2013-12-31 | 2014-04-16 | 青岛恒波仪器有限公司 | Brain-boosting and intelligence-enhancing sealwort health-care tea and preparation method thereof |
| CN103719493B (en) * | 2013-12-31 | 2016-01-27 | 青岛市市立医院 | Siberian solomonseal rhizome health-care tea of a kind of brain-nourishing intelligence-benefiting and preparation method thereof |
| CN105663965A (en) * | 2016-03-01 | 2016-06-15 | 杜延梅 | Intelligence-improvement prescription |
| CN106492038A (en) * | 2016-12-13 | 2017-03-15 | 蓝庆流 | A kind of Chinese medicine composition for strengthening memory |
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Open date: 20080924 |