CN103007146A - Healthcare nutrition powder for enhancing memory ability - Google Patents

Healthcare nutrition powder for enhancing memory ability Download PDF

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CN103007146A
CN103007146A CN2012100869249A CN201210086924A CN103007146A CN 103007146 A CN103007146 A CN 103007146A CN 2012100869249 A CN2012100869249 A CN 2012100869249A CN 201210086924 A CN201210086924 A CN 201210086924A CN 103007146 A CN103007146 A CN 103007146A
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weight portions
fructus
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herba
radix
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CN103007146B (en
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叶国生
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Changshu Bocheng Trading Co ltd
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Abstract

The invention relates to healthcare nutrition powder for enhancing memory ability. The healthcare nutrition powder consists of the following traditional Chinese medicinal materials of: polygala tenuifolia, poria cocos, rhizoma acori graminei, amomum amarum, rhizoma polygonati, spina date seed, poria with hostwood, ginseng, Mabo, schisandra chinensis, day lily, glossy privet fruit, radix asparagi, fomes japonica, passion flower, dendrobe, mulberry, centella, cortex albiziae, the fruit of Chinese wolfberry, cynomorium songaricum, and gastrodia elata, and has the functions in supplementing qi and nourishing life, promoting blood circulation to remove blood stasis, enhancing immunity of the organism, preventing aging, enhancing memory ability, and prompting cell regeneration.

Description

A kind of health care nutrition powder of memory reinforcing
Technical field
The present invention relates to a kind of health product, particularly relate to a kind of health care nutrition powder that improves immunity, memory reinforcing take Chinese herbal medicine as raw material.
Background technology
Along with improving constantly of people's living standard, how to improve immunity, nootropics slow down aging, be the subject matter of pendulum in face of everybody.A kind of " a kind of nutritive powder of memory reinforcing " of number of patent application 200610041969 disclosed at the intellectual property patent gazette in country on August 23rd, 2006.It is by being Rhizoma Gastrodiae, Auricularia, Semen Sesami Nigrum, Semen Juglandis, Thallus Laminariae (Thallus Eckloniae), Fructus Crataegi and large Fructus Jujubae to be taken by weighing post-drying by certain weight ratio be processed into powdery, again Semen sojae atricolor, Semen arachidis hypogaeae and Semen Maydis is fried respectively the post-treatment powdering.Although it has certain intelligence development functions, can not improve people immunity, can't the forgetful function of relieving insomnia.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides a kind of Chinese medicine composition, particularly relate to a kind of health care nutrition powder that improves immunity, memory reinforcing take Chinese herbal medicine as raw material.
The objective of the invention is to be achieved through the following technical solutions.
Chinese medicine composition of the present invention is to be made by the crude drug of following weight proportion:
Radix Polygalae 10~14 weight portions, Poria 10~14 weight portions, Rhizoma Acori Graminei 4~8 weight portions, Fructus Alpiniae Oxyphyllae 4~8 weight portions, Rhizoma Polygonati 2~6 weight portions, Semen Ziziphi Spinosae 2~6 weight portions, Poria cum Radix Pini's 2~6 weight portions, Radix Ginseng 2~6 weight portions, vigorous 2~6 weight portions of fiber crops, Fructus Schisandrae Chinensis 2~6 weight portions, Hemerocallis fulva L. 2~6 weight portions, Fructus Ligustri Lucidi 2~6 weight portions, Radix Asparagi 2~6 weight portions, Ganoderma 2~6 weight portions, Herba Passiflorae Caeruleae 2~6 weight portions, Herba Dendrobii 2~5 weight portions, Fructus Mori 2~5 weight portions, Cortex Albiziae 2~5 weight portions, Herba Centellae 2~5 weight portions, Fructus Lycii 1~5 weight portion, Herba Cynomorii 1.5~3.5 weight portions, Rhizoma Gastrodiae 0.2~0.8 weight portion.
Chinese medicine composition preferred feedstock medicine weight portion of the present invention is:
Radix Polygalae 12 weight portions, Poria 12 weight portions, Rhizoma Acori Graminei 6 weight portions, Fructus Alpiniae Oxyphyllae 6 weight portions, Rhizoma Polygonati 4 weight portions, Semen Ziziphi Spinosae 4 weight portions, Poria cum Radix Pini's 4 weight portions, Radix Ginseng 4 weight portions, vigorous 4 weight portions of fiber crops, Fructus Schisandrae Chinensis 4 weight portions, Hemerocallis fulva L. 4 weight portions, Fructus Ligustri Lucidi 4 weight portions, Radix Asparagi 4 weight portions, Ganoderma 4 weight portions, Herba Passiflorae Caeruleae 4 weight portions, Herba Dendrobii 3.5 weight portions, Fructus Mori 3.5 weight portions, Herba Centellae 3.5 weight portions, Cortex Albiziae 3.5 weight portions, Fructus Lycii 3 weight portions, Herba Cynomorii 2.5 weight portions, Rhizoma Gastrodiae 0.5 weight portion.
The preparation method of pharmaceutical composition of the present invention is:
At first: according to the part by weight weighting raw materials, wash cleaning.
Second step: warm macerating 1 in the warm water of 80 ℃ of the crude drug inputs after cleaning is as a child decocted with water 3 times, add the 8-10 times of water yield of crude drug at every turn, decocted the extracting solution that rear collection is 3 times 3 hours/time.
The 3rd step: will collect extracting solution and filter its amalgamation liquid in the mode of negative pressure leaching.
The 4th step: the extracting solution after the above-mentioned filtration is put in the single-effect external circulation thin film evaporation instrument, and negative pressure is concentrated into the extractum that ratio of specific heat is 1.2mg/ml.
The 5th step: above-mentioned extractum can by vacuum drying mode, be made dry product with extractum.
The 6th goes on foot: dry product being put in the multifunctional crusher pulverized, is 80~100 orders until pulverize the order number.
The 7th step: dried powder carries out sterilization treatment.
The 8th step: be packaged into 5g * 10 bag/boxes.
Product of the present invention is powder, and it not only replenishes the necessary trace element of human body but also nootropics and memory.
Radix Polygalae:
Another name, Lush is around, sour jujube Tu, sour jujube aster, Herba Ceratophylli Demeersi, Chicken Drumsticks, little clavus, little grass roots.Nature and flavor are hot, bitter, slightly warm in nature.Can mind tranquilizing and the heart calming, eliminate the phlegm have one's ideas straightened out, removing toxic substances and promoting subsidence of swelling.Cure mainly irritability, palpitation with fear insomnia, forgetful, infantile convulsion, cough with copious phlegm, carbuncle carbuncle on the back, breast swell and pain.
Rhizoma Acori Graminei:
Another name, prosperous, Chinese onion when Rhizoma Acori Graminei, prosperous sun, prosperous grass, Yao, Yao's fragrant-flowered garlic, haze tallow, spring snow etc.The nature and flavor acrid in the mouth, tepor.Can have one's ideas straightened out, eliminating phlegm is regulated the flow of vital energy, and invigorates blood circulation, and loose wind dries.Cure mainly and control that epilepsy, syncope due to accumulation of phlegm, calentura coma, deafness with qi stagnation, ambition unhappiness, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury, gastral cavity painful abdominal mass are not hungry, mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.
Poria:
Another name lies prostrate tire, Poria, Fu rabbit, loose potato, Masson Pine potato, Song Ling in Fu Tu, Poria, Fu Ling, Fu Ling, volt Tu, loose fat, deep red morning.Energy diuretic medicine, diuretics with the action of eliminating dampness.Cure mainly dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, insufficiency of the spleen lack of appetite, have loose bowels, palpitation and restlessness, insomnia forgetfulness, seminal emission nebulousurine.
Poria cum Radix Pini:
Another name, Lignum Poria.Cure mainly mind tranquilizing and the heart calming.Be applicable to mind calming; Calm the nerves; Diuretic.Main palpitation with fear; Forgetful; Forgetful insomnia; Infantile convulsion; Dysuria.
Radix Ginseng:
Another name, SHANSHEN, Park Ginseng, people's rank, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.), Rhizoma Panacis Japonici, SHENCAO, Sphallerocarpus gracilis, Herba Wedeliae Wallichii, Herba Stellariae Saxatilis, hundred chi pestles, extra large fat, the beautiful door screen of golden well, Radix Ginseng, battledore.Nature and flavor: property is flat, sweet in the mouth, little hardship, tepor.The function strongly invigorating primordial QI, multiple arteries and veins takes off invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the Fructus Alpiniae Oxyphyllae of calming the nerves admittedly.
Cortex Albiziae:
Another name closes confused skin, night platform skin, Herba Albiziae veneer.Function: the resolving depression of calming the nerves, the eliminating carbuncle of invigorating blood circulation.Cure mainly irritability; Melancholy, sleeplessness, inside and outside carbuncle and ulcer, traumatic injury.
Semen Ziziphi Spinosae:
Another name, Semen Ziziphi Spinosae, jujube nucleus, Fructus Choerospondiatis core, Ziziphi Spinosae, jujube nucleus, Ziziphi Spinosae, sour jujube core, sour jujube reality, Spina jujubae reality, Er core, Er Semen Ziziphi Spinosae etc.Nature and flavor are sweet, and are flat.Function: mind tranquilizing and the heart calming; Nourishing the liver; Arresting sweating.
Fiber crops are vigorous:
Different name, Spica Cannabis Tener.Spica Cannabis Tener is the young tender fruit ear of moraceae plants Fructus Cannabis.Can dispel the wind pain relieving, spasmolytic.Control gout, arthromyodynia, demented, insomnia, cough with asthma.
Fructus Schisandrae Chinensis:
Medicine name: Fructus Schisandrae Chinensis.Another name: Wei, Chi Zhu, profound and, can and, five Fructus Armeniacae Mumes, Fructus Zanthoxyli Plansipini.Effect classification: astringent medicinal.Can restrain astringent or styptic treatment for spontaneous sweating; Supplementing QI for promoting the production of body fluid; Mind tranquilizing and the heart calming.Cure mainly cough dyspnea due to deficiency, emission, urinate quite the enuresis, incessant chronic diarrhea, spontaneous sweating, Tianjin wound are thirsty, palpitation and insomnia.
Hemerocallis fulva L.:
Another name, Radix hemerocalis plicatae, also name Flos Hemerocallis.The sweet cold of Hemerocallis fulva L. nature and flavor, the effect that have dampness removing heat, the chest stuffiness relieving, helps digestion.Control chest and diaphragm dysphoria with smothery sensation, jaundice, hot urination.Cure mainly clearing away heat and promoting diuresis, cooling blood for hemostasis.
Fructus Ligustri Lucidi:
Another name: Fructus Ligustri Lucidi reality, Fructus Ilicis Purpureae, quick-fried lattice flea, white beeswax tree, Mus Chinese catalpa.Nature and flavor: sweet; Bitter; Cool in nature.Can liver and kidney tonifying, clearind deficient heat, make eye bright.Cure mainly Light-headedness, soreness of the waist and knees, seminal emission, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision.
Rhizoma Polygonati:
Call imperial rank, Pseudobulbus Bletillae (Rhizoma Bletillae), rabbit bamboo, hanging bead, chicken lattice, rice dried meat, Tu bamboo, deer bamboo, Rhizoma Paridis, rescue poor, penta sesame, Rhizoma Polygonati Odorati, careless lattice, horse arrow, celestial being's surplus grain, gas essence, Rhizoma Zingiberis Recens etc.Nature and flavor: sweet; Flat.The energy nourishing YIN and moistening the lung; Invigorating the spleen and replenishing QI, Zishen fill fine.Cure mainly deficiency of YIN chronic cough, xeropulmonary cough, insufficiency of the spleen weak, lack of appetite xerostomia, quench one's thirst, deficiency of the kidney soreness of the waist and knees, impotence and seminal emission, tinnitus order are dark, early whitening of beard and hair, body are empty wins thin, wind favus disease.
Herba Dendrobii:
Another name woods orchid, taboo life, Du Lan, Dendrobium nobile Lindl flower, Qian Nianrun, Dendrobium denneanum Kerr., bracketplant.Function cures mainly reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Be used for cloudy impairment of body fluid and lose, the xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.
Fructus Mori:
Another name Mulberry reality, Shen, black mulberry, civil and military real, black mulberry, Mulberry Fructus Jujubae, Fructus Mori, Mulberry grain, sorosis.Nature and flavor are sweet, sour, and are cold.Function cures mainly tonifying liver, and kidney tonifying relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid.Control hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.
Herba Cynomorii:
Another name: trivial sun, Herba Cynomorii, rust iron staff, ball top, yellow bone wolf, Songaria Cynomorium Herb, sheep lock do not draw.Nature and flavor: sweet in the mouth; Warm in nature.The energy kidney invigorating and YANG supporting; The relieving constipation of benefit intestinal.Cure mainly impotence due to deficiency of the kidney, seminal emission premature ejaculation, flaccidity and weakness of the lower limbs, empty people's constipation.
Herba Passiflorae Caeruleae:
Different name Barringtonia racemosa (L.) B L.ex Do. flower, the West are brought up, are turned heart lotus, turn a lotus.Major function is used for neuralgia, the insomnia, and the diseases such as menstrual pain and dysentery have anesthesia and sedation.Except the wind heat clearing away, on cough and reduce phlegm.Control the wind heat giddy, the nasal obstruction watery nasal discharge.
Radix Asparagi:
Another name Tianmen, Men winter, large when a door root, Radix Asparagi.Nature and flavor: sweet, bitter, cold.The energy YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Cure mainly for dryness of the lung dry cough, cough due to consumptive disease, thirsty, the vexed insomnia of Tianjin wound, interior-heat quench one's thirst, dryness of the intestine constipation, diphtheria.Anticancer, the clear gesture that relieves internal heat reduces phlegm, nourshing Yin and drynsessmoistening prescription.
Herba Centellae:
Herb or whole herb with root for the samphire Herba Centellae.Clearing away heat-damp and promoting diuresis is arranged, the effect of subduing swelling and detoxicating.Control eruptive disease stomachache, diarrhea due to summer-heat, dysentery, jaundice due to damp-heat, sand Stranguria, stranguria with blood is told, nosebleed, hemoptysis, conjunctival congestion, larynx is swollen, rubella, scabies, furuncle carbuncle poison, traumatic injury.Central action there are calmness, stable effect.Can treat skin ulcer to skin histology, such as intractable wound, tuberculosis of skin, leprosy etc.Antibacterial action is arranged, and Asiaticoside can be treated leprosy.And can slightly suppress the effect of acetylcholine.
Fructus Alpiniae Oxyphyllae
Nature and flavor: acrid in the mouth; Warm in nature.Can warming spleen and stopping diarrha saliva, the warming the kidney reducing urination controlling nocturnal emission with astringent drugs taken the photograph.Cure mainly Deficiency and coldness of spleen and stomach, vomit, have loose bowels, coldly in the abdomen educate, mouthful many salivas, enuresis due to deficiency of the kidney, frequent micturition, seminal emission, nebulousurine.
Ganoderma:
Another name Fructificatio Amaurodermatis Rudae, profound sesame, Ganoderma, sweet in the mouth, property is flat.Mainly contain ergosterol, organic acid, glucosamine, polysaccharide, resin, mannitol, polysaccharide polyol, fatty acid, contain again alkaloid, lactone, coumarin, water soluble protein and multiple enzyme.The Ganoderma strengthening the body resistance strengthens immunologic function, improves the great function of Abwehrkraft des Koepers.It is two-ways regulation function of human body balance on the whole, transfers the internal body vigor, and balance the body metabolism function improves the autoimmune ability, impels whole internal organs or organ function normalization.
Fructus Lycii:
Another name Fructus Lycii, Gou Qizi, Fructus Lycii red real, Radix Betae is sub, FRUCTUS LYCII BARBARI, Canis familiaris L. milk, dark purple green pepper, Chinese holly hoof, FRUCTUS LYCII, frame, Chinese holly eggplant eggplant, red ear pendant, blood Fructus Lycii, Chinese holly ground bud, Fructus Lycii bean, blood Fructus Lycii, fructus lycii sinensis etc.Nature and flavor: sweet in the mouth; Property is put down.The energy nourishing the liver; Nourishing kidney; Lung moistening.Cure mainly caused by liver and kidney deficiency, have a dizzy spell, visual one clear, soreness of the waist and knees, the expensive essence of sexual impotence, cough due to consumptive disease, the taking fluids profusely of quenching one's thirst.
Rhizoma Gastrodiae
Have another name called rhizoma gastrodiae, from mother, yellow moccasin flower, SHENCAO, solely shake sesame, rhizoma gastrodiae fat, DINGFENGCAO, close from grass, solely shake, automatically grass, water Rhizoma Solani tuber osi.Be rich in gastrodine, Vanillin, protein, aminoacid, trace element.Its property is hot, temperature, nontoxic, and epilepsy is arranged, and resisting throbs with fear faints rheumatism.Calmness, spasmolytic, analgesia, tonify deficiency, the effect of suppressing the hyperactive liver to relieve the wind syndrome.Function cures mainly the suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion.Be used for having a headache dizzy numb limbs and tense tendons, epilepsy clonus, tetanus.Feel dizzy neurasthenia, anemofrigid-damp arthralgia, the diseases such as infantile convulsion.Clinical practice proves that vascular nervous headache, cerebral concussion sequela etc. are had significant curative effect.
The present invention utilizes Radix Polygalae to be monarch drug, Radix Polygalae have physique strengthening and intelligence benefiting and strengthen the function of the regional metabolism of brain, reach mind tranquilizing and the heart calming, treatment palpitation with fear insomnia, forgetful; Take Poria, Rhizoma Acori Graminei, Fructus Alpiniae Oxyphyllae, Fructus Schisandrae Chinensis as ministerial drug; have one's ideas straightened out regulate the flow of vital energy, invigorate blood circulation dry, lung is grown in nourishing the liver, mind tranquilizing and the heart calming, warming spleen and stopping diarrha, calm tonify deficiency; particularly by " taurine " the clever factor in Fructus Alpiniae Oxyphyllae; reach people's enhancing growth, slow down aging, raising human body DOPAMINE CONTENT IN RABBIT, thereby add attention, reagency and the memory that promotes human brain.Assistant is vigorous with Fructus Lycii, Semen Ziziphi Spinosae, Herba Passiflorae Caeruleae, Rhizoma Polygonati, Poria cum Radix Pini, Radix Ginseng, Cortex Albiziae, fiber crops, Hemerocallis fulva L., Fructus Ligustri Lucidi, Herba Dendrobii, Fructus Mori, Radix Asparagi, Herba Centellae, Ganoderma, Herba Cynomorii, Rhizoma Gastrodiae reach the Fructus Alpiniae Oxyphyllae of calming the nerves, supplementing QI for promoting the production of body fluid, nourishing essence-blood jointly, the effect relieving convulsion, eliminating phlegm and calming wind of calming the nerves, strengthen function, the balance the body function equilibrium of each internal organs, reach the function that improves immunity; Radix Ginseng can strengthen central nervous system's process of excitation, also can strengthen process of inhibition, makes its mutual balance, improves corticocerebral regulating action; Also scalable function of nervous system makes anxiety cause disorderly nervous process to be recovered.All medicine comprehensive functions are mended bone marrow and are increased brains, strong health, memory reinforcing, nootropics.
The present invention compared with prior art has the trace element that can replenish human body, benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, raising immunity of organisms, prevents aging, nootropics and memory, promotes the function of brain cell regeneration.
Product of the present invention is called " clever drink ".
For health-care effect of the present invention is described, hundreds of routine clinical trials have been carried out.
Case 1:
Permitted * *; The woman; 52 years old; The teacher; Jinzhou City, Liaoning Province
Intractable insomnia, difficulty falling asleep for many years, morning three or four dyschezia of just waking up with sleeping, daytime lassitude, headache is irritated.Took the clever drink of the present invention one month, easily sleeping, sleep quality has had very large improvement, and insomnia has obtained solving thoroughly, the transference cure that headache is irritated, and the mental status takes a turn for the better greatly.
Case 2:
Liu * *, one's mid-30s, trade, Zhejiang
Dysmenorrhea more than ten years, menstruation a few days ago lower abdomen dull pain takes a turn for the better after the menstruation unbearably, and through distending pain of the breast a few days ago.After taking clever drink two boxes of the present invention, in the period just do not have a colic symptoms, do not feel through fore udder yet and distending pain continue to take a course for the treatment of, dysmenorrhea do not occur so far again and through the fore udder distending pain.
Case 3:
Zhao *, man, 15 years old, Shandong
Defecated the children's from 2 years old just dry, all will squat half a day to the lavatory at every turn, out rear flushed face with red ears has become habitually constipation.By the agency of is taken the clever drink of the present invention, every day twice, and each one, afterwards stool beginning deliquescing in 5 days, ambassador is fully normal after 1 month.
Case 4:
The Wei * *, woman, 9 years old, Beijing
Hyperkinetic syndrome once tossed about in bed to hurry back and forth in the treatment of Shandong Duo Jia large hospital for many years, and curative effect is all not obvious, and after the clever drink of the present invention was taken in friend's introduction, effect was fine behind the first quarter moon, and hyperkinetic syndrome is very significantly improved.Now still in continuing to take.
Case 5:
The king * *; The woman; 41 years old; Level in Anshan city, liaoning province
Weak and sickly, easy catching a cold, chronic gynaecopathia is burdened with for many years, often takes medicine.By the agency of is taken the clever drink of the present invention.Namely feel after ten days and continue appetite enhancing, strong from head to foot to take after two months, body constitution obviously strengthens, and does not all have flu always, and sallow face originally becomes ruddy, and gynaecopathia for many years also turns for the better by and large.
Case 6:
Lee * *, man, 39 years old, trade, Guangdong
Suffered from prostatosis approximately 3 years, heavy when light during the state of an illness, one or two minute ability urine of urine when light; Urine bifurcated when heavy, often.After the contact the present invention clever drink, know that the clever kitchenware of the present invention has the kidney invigorating, keeps fit function, so try to have bought the clever drink-service usefulness of the present invention, I had never expected and just eat less than a box, the waiting time of just feeling to urinate has shortened.Continued to take four months time, dysuric problem solves fully.
One, clinical experiment:
In order to observe the present invention's " clever drinking particle " clinical efficacy, we select hypomnesis patient 130 examples, are divided at random each 65 example for the treatment of group and matched group, take respectively 5.0 g/timess of the clever drink of the present invention and starch, and 3 times/days, totally 16 weeks.Before treatment and treat the mensuration of carrying out memory quotient after 16 weeks, carry out simultaneously the observation of untoward reaction.
The result:
Clever drinking particle group total effective rate 88%, matched group are that 40%, two group of comparing difference is very significant (r=90.37, P<0.01).Patient's memory improves, and the treatment group memory quotient is on average rised in value (17.3 ± 11.1) minute, matched group on average rise in value (4.6 ± 7.2) minute.Comparing difference is very significant (t=6.33, P<0.01) between two groups.And the side reaction of clever drink is less.
Conclusion: clever drinking particle has preferably restitution to the hypomnesis of after craniocerebral injury.
Two, toxicity research:
1, acute toxicity testing: choosing 20 of healthy rats, is 9.38 weight portions/KQ (consumption per day of quite being grown up 626 times) through gastric infusion the present invention " clever drink ".
Test shows: malicious epiphenomenon does not appear in rat, and is in good condition.
2, long term toxicity test: 20 healthy rats are divided into groups by 0.5 weight portion/KQ, 1 weight portion/KQ, 2 weight portions/KQ, gastric infusion every day " clever drink " once, successive administration 3 months, with matched group relatively.
The result shows: the general status of large, medium and small dosage treated animal is good, hematological examination, and serum weight portion PT, the experiment such as plasma urea nitrogen is all normal, and each dirty body is than comparing no significant difference, each organ-tissue pathologic finding no abnormality seen with matched group.
Three, pharmaceutical research:
Mice is divided into 5 groups: Normal group, high fat memory impairment model group, positive controls (DHA), low dose group (being equivalent to people's consumption 3 bags/day), high dose group (being equivalent to people's consumption 6 bags/day)
Every group of 15 animals, except Normal group, all the other each groups all give High-fat diet.The feeding cycle is 3 months.
Experimental result and conclusion
(1) diving tower experiment
1, basis for estimation:
Show to judge the memory difference of each treated animal by the behavioristics of each treated animal relatively.It is longer that mice jumps off incubation period of platform, illustrates that the brain memory functional rehabilitation of mice must be better; The percentage rate of animal of being shocked by electricity is lower, illustrates that the brain memory functional rehabilitation of mice must be better.
2, experimental result:
Take the percentage rate that microalgae Semen Lini oil soft capsule high dose group can significant prolongation memory impairment mice be jumped off the incubation period of platform and reduced the animal of being shocked by electricity.The diving tower experimental result:
Figure BSA00000692478900131
3, experiment conclusion:
(1) long term high-fat diet can cause the cerebral nerve damage, shows as memory function impaired.
(2) the clever drink of long-term taking the present invention can improve the brain memory damage, helps to keep and recover the memory function of brain.
(2) water maze laboratory
1, basis for estimation:
Show to judge the memory difference of each treated animal by the behavioristics of each treated animal relatively.It is shorter that mice arrives the time of labyrinth terminal point, illustrates that the brain memory functional rehabilitation of mice must be better; The percentage rate that mice arrives the labyrinth terminal point is higher, illustrates that the brain memory functional rehabilitation of mice must be better.
2, experimental result:
Compare with model group, low dose group can significantly reduce the time that mice arrives the labyrinth terminal point; Low, high dose group all can significantly improve the percentage rate that mice is reached home.
The water maze laboratory result:
Figure BSA00000692478900132
3, experiment conclusion:
(1) long term high-fat diet can cause the cerebral nerve damage, shows as memory function impaired.
(2) long-term taking microalgae Semen Lini oil soft capsule can improve the brain memory damage, helps to keep and recover the memory function of brain, and then improves the ability of learning and memory.
(3) blood fat TC, TG assay
1, basis for estimation:
Judge the effect for reducing blood fat of microalgae Semen Lini oil soft capsule by the content of TC, TG in each treated animal serum relatively.The content of TC, TG is lower, illustrates that the effect of microalgae Semen Lini oil soft capsule auxiliary antilipemic is better.
2, experimental result:
Low, high dose group all can significantly reduce TC, the TG of high fat mice, and especially the blood lipid level of high dose group mice is very near Normal group
Blood fat TC, TG assay result:
3, experiment conclusion:
(1) long term high-fat diet can cause blood lipid level to raise, and health is caused damage.
(2) long-term taking microalgae Semen Lini oil soft capsule, effectively the blood fat reducing level reduces high fat diet to the adverse effect of blood fat health.
(4) the brain lipofuscin content is measured
1, basis for estimation:
Study microalgae Semen Lini oil soft capsule to the health-care effect of brain by the content of the brain lipofuscin of each treated animal relatively.Lipofuscin content is lower, illustrates that microalgae Semen Lini oil soft capsule delays the effect of brain aging better.
2, experimental result:
Low dose group can significantly reduce the content of mouse brain lipofuscin.
Brain lipofuscin content (the ug/g brain is heavy):
Negative control High fat is fed Positive control Low dosage High dose
50 68 31 40 55
Experiment conclusion:
(1) long term high-fat diet can cause the lipofuscin content in the brain to increase.
(2) the clever drink of long-term taking the present invention can effectively reduce the lipofuscin deposition in the brain, alleviates high fat diet to the damage of brain neuroblastoma, helps to keep the brain function, delays brain aging.
Four, research conclusion
This experimentation shows, long-term taking is invented clever kitchenware auxiliary improvement of memory, blood fat reducing, delay the effects such as brain aging.
The specific embodiment
Below in conjunction with embodiment the present invention is further detailed.
Embodiment 1
Take by weighing crude drug of the present invention according to following weight portion:
Radix Polygalae 10 weight portions, Poria 14 weight portions, Rhizoma Acori Graminei 8 weight portions, Fructus Alpiniae Oxyphyllae 8 weight portions, Rhizoma Polygonati 6 weight portions, Semen Ziziphi Spinosae 6 weight portions, Poria cum Radix Pini's 6 weight portions, Radix Ginseng 6 weight portions, vigorous 6 weight portions of fiber crops, Fructus Schisandrae Chinensis 6 weight portions, Hemerocallis fulva L. 6 weight portions, Fructus Ligustri Lucidi 6 weight portions, Radix Asparagi 6 weight portions, Ganoderma 6 weight portions, Herba Passiflorae Caeruleae 6 weight portions, Herba Dendrobii 5 weight portions, Fructus Mori 5 weight portions, Cortex Albiziae 5 weight portions, Herba Centellae 5 weight portions, Fructus Lycii 5 weight portions, Herba Cynomorii 3.5 weight portions, Rhizoma Gastrodiae 0.8 weight portion.
Above-mentioned Chinese crude drug is washed cleaning, then warm macerating 1 in the warm water of 80 ℃ of the crude drug inputs after cleaning is as a child decocted with water 3 times, add the 8-10 times of water yield of crude drug at every turn, decocted the extracting solution that rear collection is 3 times 3 hours/time.Filter its amalgamation liquid with collecting extracting solution in the mode of negative pressure leaching.Extracting solution after the above-mentioned filtration is put in the single-effect external circulation thin film evaporation instrument, and negative pressure is concentrated into the extractum that ratio of specific heat is 1.2mg/ml.Above-mentioned extractum can by vacuum drying mode, be made dry product with extractum.Dry product being put in the multifunctional crusher pulverize, is 80~100 orders until pulverize the order number, and dried powder is packaged into product after carrying out sterilization treatment.
Embodiment 2
Take by weighing crude drug of the present invention according to following weight portion:
Radix Polygalae 14 weight portions, Poria 10 weight portions, Rhizoma Acori Graminei 4 weight portions, Fructus Alpiniae Oxyphyllae 4 weight portions, Rhizoma Polygonati 2 weight portions, Semen Ziziphi Spinosae 2 weight portions, Poria cum Radix Pini's 2 weight portions, Radix Ginseng 2 weight portions, vigorous 2 weight portions of fiber crops, Fructus Schisandrae Chinensis 2 weight portions, Hemerocallis fulva L. 2 weight portions, Fructus Ligustri Lucidi 2 weight portions, Radix Asparagi 2 weight portions, Ganoderma 2 weight portions, Herba Passiflorae Caeruleae 2 weight portions, Herba Dendrobii 2 weight portions, Fructus Mori 2 weight portions, Cortex Albiziae 2 weight portions, Herba Centellae 2 weight portions, Fructus Lycii 1 weight portion, Herba Cynomorii 1.5 weight portions, Rhizoma Gastrodiae 0.2 weight portion.
Above-mentioned Chinese crude drug is washed cleaning, then warm macerating 1 in the warm water of 80 ℃ of the crude drug inputs after cleaning is as a child decocted with water 3 times, add the 8-10 times of water yield of crude drug at every turn, decocted the extracting solution that rear collection is 3 times 3 hours/time.Filter its amalgamation liquid with collecting extracting solution in the mode of negative pressure leaching.Extracting solution after the above-mentioned filtration is put in the single-effect external circulation thin film evaporation instrument, and negative pressure is concentrated into the extractum that ratio of specific heat is 1.2mg/ml.Above-mentioned extractum can by vacuum drying mode, be made dry product with extractum.Dry product being put in the multifunctional crusher pulverize, is 80~100 orders until pulverize the order number, and dried powder is packaged into product after carrying out sterilization treatment.
Embodiment 3
Take by weighing crude drug of the present invention according to following weight portion:
Radix Polygalae 12 weight portions, Poria 12 weight portions, Rhizoma Acori Graminei 6 weight portions, Fructus Alpiniae Oxyphyllae 6 weight portions, Rhizoma Polygonati 4 weight portions, Semen Ziziphi Spinosae 4 weight portions, Poria cum Radix Pini's 4 weight portions, Radix Ginseng 4 weight portions, vigorous 4 weight portions of fiber crops, Fructus Schisandrae Chinensis 4 weight portions, Hemerocallis fulva L. 4 weight portions, Fructus Ligustri Lucidi 4 weight portions, Radix Asparagi 4 weight portions, Ganoderma 4 weight portions, Herba Passiflorae Caeruleae 4 weight portions, Herba Dendrobii 3.5 weight portions, Fructus Mori 3.5 weight portions, Herba Centellae 3.5 weight portions, Cortex Albiziae 3.5 weight portions, Fructus Lycii 3 weight portions, Herba Cynomorii 2.5 weight portions, Rhizoma Gastrodiae 0.5 weight portion.
Above-mentioned Chinese crude drug is washed cleaning, then warm macerating 1 in the warm water of 80 ℃ of the crude drug inputs after cleaning is as a child decocted with water 3 times, add the 8-10 times of water yield of crude drug at every turn, decocted the extracting solution that rear collection is 3 times 3 hours/time.Filter its amalgamation liquid with collecting extracting solution in the mode of negative pressure leaching.Extracting solution after the above-mentioned filtration is put in the single-effect external circulation thin film evaporation instrument, and negative pressure is concentrated into the extractum that ratio of specific heat is 1.2mg/ml.Above-mentioned extractum can by vacuum drying mode, be made dry product with extractum.Dry product being put in the multifunctional crusher pulverize, is 80~100 orders until pulverize the order number, and dried powder is packaged into product after carrying out sterilization treatment.
Embodiment 4
Take by weighing crude drug of the present invention according to following weight portion:
Radix Polygalae 13 weight portions, Poria 12 weight portions, Rhizoma Acori Graminei 6 weight portions, Semen Ziziphi Spinosae 6 weight portions, Fructus Alpiniae Oxyphyllae 6 weight portions, Rhizoma Polygonati 4 weight portions, Fructus Lycii 3 weight portions, Poria cum Radix Pini's 3 weight portions, Radix Ginseng 3 weight portions, Cortex Albiziae 3 weight portions, vigorous 3 weight portions of fiber crops, Fructus Schisandrae Chinensis 5 weight portions, Hemerocallis fulva L. 3 weight portions, Fructus Ligustri Lucidi 4 weight portions, Herba Dendrobii 4 weight portions, Fructus Mori 4 weight portions, Radix Asparagi 4 weight portions, Herba Centellae 3.5 weight portions, Ganoderma 4 weight portions, Herba Cynomorii 3 weight portions, Herba Passiflorae Caeruleae 3 weight portions, Rhizoma Gastrodiae 0.5 weight portion.
Above-mentioned Chinese crude drug is washed cleaning, then warm macerating 1 in the warm water of 80 ℃ of the crude drug inputs after cleaning is as a child decocted with water 3 times, add the 8-10 times of water yield of crude drug at every turn, decocted the extracting solution that rear collection is 3 times 3 hours/time.Filter its amalgamation liquid with collecting extracting solution in the mode of negative pressure leaching.Extracting solution after the above-mentioned filtration is put in the single-effect external circulation thin film evaporation instrument, and negative pressure is concentrated into the extractum that ratio of specific heat is 1.2mg/ml.Above-mentioned extractum can by vacuum drying mode, be made dry product with extractum.Dry product being put in the multifunctional crusher pulverize, is 80~100 orders until pulverize the order number, and dried powder is packaged into product after carrying out sterilization treatment.

Claims (2)

1. the health care nutrition powder of a memory reinforcing is characterized in that it is to be made by the crude drug of following weight proportioning: Radix Polygalae 10~14 weight portions, Poria 10~14 weight portions, Rhizoma Acori Graminei 4~8 weight portions, Fructus Alpiniae Oxyphyllae 4~8 weight portions, Rhizoma Polygonati 2~6 weight portions, Semen Ziziphi Spinosae 2~6 weight portions, Poria cum Radix Pini's 2~6 weight portions, Radix Ginseng 2~6 weight portions, vigorous 2~6 weight portions of fiber crops, Fructus Schisandrae Chinensis 2~6 weight portions, Hemerocallis fulva L. 2~6 weight portions, Fructus Ligustri Lucidi 2~6 weight portions, Radix Asparagi 2~6 weight portions, Ganoderma 2~6 weight portions, Herba Passiflorae Caeruleae 2~6 weight portions, Herba Dendrobii 2~5 weight portions, Fructus Mori 2~5 weight portions, Cortex Albiziae 2~5 weight portions, Herba Centellae 2~5 weight portions, Fructus Lycii 1~5 weight portion, Herba Cynomorii 1.5~3.5 weight portions, Rhizoma Gastrodiae 0.2~0.8 weight portion.
2. health care nutrition powder according to claim 1 is characterized in that it is to be made by the crude drug of following weight proportioning:
Radix Polygalae 12 weight portions, Poria 12 weight portions, Rhizoma Acori Graminei 6 weight portions, Fructus Alpiniae Oxyphyllae 6 weight portions, Rhizoma Polygonati 4 weight portions, Semen Ziziphi Spinosae 4 weight portions, Poria cum Radix Pini's 4 weight portions, Radix Ginseng 4 weight portions, vigorous 4 weight portions of fiber crops, Fructus Schisandrae Chinensis 4 weight portions, Hemerocallis fulva L. 4 weight portions, Fructus Ligustri Lucidi 4 weight portions, Radix Asparagi 4 weight portions, Ganoderma 4 weight portions, Herba Passiflorae Caeruleae 4 weight portions, Herba Dendrobii 3.5 weight portions, Fructus Mori 3.5 weight portions, Herba Centellae 3.5 weight portions, Cortex Albiziae 3.5 weight portions, Fructus Lycii 3 weight portions, Herba Cynomorii 2.5 weight portions, Rhizoma Gastrodiae 0.5 weight portion.
CN201210086924.9A 2012-03-29 2012-03-29 Healthcare nutrition powder for enhancing memory ability Expired - Fee Related CN103007146B (en)

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103504371A (en) * 2013-08-12 2014-01-15 杨茹芹 Tranquilizing crisp-fried shelled melon seed and manufacturing method thereof
CN103689427A (en) * 2013-12-06 2014-04-02 陈瑞 Wheat germ flour with soy sauce flavor and preparation method thereof
CN103719493A (en) * 2013-12-31 2014-04-16 青岛恒波仪器有限公司 Brain-boosting and intelligence-enhancing sealwort health-care tea and preparation method thereof
CN103734587A (en) * 2013-12-06 2014-04-23 颍上县天好食品有限公司 Rice bran health powder and preparation method thereof
CN104095227A (en) * 2014-06-19 2014-10-15 马鞍山市心洲葡萄专业合作社 Nutrient bamboo shoot powder and preparation method thereof
CN104095188A (en) * 2014-06-19 2014-10-15 马鞍山市心洲葡萄专业合作社 Pearl health-care powder capable of nourishing liver and improving visual acuity and preparation method thereof
CN104547264A (en) * 2014-12-22 2015-04-29 山东天地健生物工程有限公司 Capsules for improving memory and preparation method thereof
CN104621559A (en) * 2015-01-16 2015-05-20 熊文花 Health product with effects of refreshing brain and improving intelligence and preparation method thereof
CN106492038A (en) * 2016-12-13 2017-03-15 蓝庆流 A kind of Chinese medicine composition for strengthening memory

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1453034A (en) * 2003-06-06 2003-11-05 广州万健科技发展有限公司 Chinese medicine composition for treating heart, kidney and multiple-organ failure and its prepn
CN1903322A (en) * 2006-08-15 2007-01-31 倪文城 Medicine for treating myocarditis
CN101024040A (en) * 2007-03-28 2007-08-29 海城市中医院 Medicine preparation for invigorating intelligence and recovering paralysis
CN101850058A (en) * 2010-05-17 2010-10-06 广东一禾药业有限公司 Chinese medicament for preventing and treating agrypnia, memory loss and alzheimers disease and method
CN102370924A (en) * 2011-09-28 2012-03-14 邓华伦 Chinese herbal medicine for treating heart impediment symptom

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1453034A (en) * 2003-06-06 2003-11-05 广州万健科技发展有限公司 Chinese medicine composition for treating heart, kidney and multiple-organ failure and its prepn
CN1903322A (en) * 2006-08-15 2007-01-31 倪文城 Medicine for treating myocarditis
CN101024040A (en) * 2007-03-28 2007-08-29 海城市中医院 Medicine preparation for invigorating intelligence and recovering paralysis
CN101850058A (en) * 2010-05-17 2010-10-06 广东一禾药业有限公司 Chinese medicament for preventing and treating agrypnia, memory loss and alzheimers disease and method
CN102370924A (en) * 2011-09-28 2012-03-14 邓华伦 Chinese herbal medicine for treating heart impediment symptom

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103504371A (en) * 2013-08-12 2014-01-15 杨茹芹 Tranquilizing crisp-fried shelled melon seed and manufacturing method thereof
CN103504371B (en) * 2013-08-12 2016-03-23 杨茹芹 One is calmed the nerves crisp-fried shelled melon seed and preparation method thereof
CN103689427B (en) * 2013-12-06 2016-03-02 陈瑞 A kind of flavor of soy sauce wheat germ powder and preparation method thereof
CN103734587A (en) * 2013-12-06 2014-04-23 颍上县天好食品有限公司 Rice bran health powder and preparation method thereof
CN103689427A (en) * 2013-12-06 2014-04-02 陈瑞 Wheat germ flour with soy sauce flavor and preparation method thereof
CN103734587B (en) * 2013-12-06 2016-03-23 颍上县天好食品有限公司 A kind of rice bran health powder and preparation method thereof
CN103719493B (en) * 2013-12-31 2016-01-27 青岛市市立医院 Siberian solomonseal rhizome health-care tea of a kind of brain-nourishing intelligence-benefiting and preparation method thereof
CN103719493A (en) * 2013-12-31 2014-04-16 青岛恒波仪器有限公司 Brain-boosting and intelligence-enhancing sealwort health-care tea and preparation method thereof
CN104095227A (en) * 2014-06-19 2014-10-15 马鞍山市心洲葡萄专业合作社 Nutrient bamboo shoot powder and preparation method thereof
CN104095188A (en) * 2014-06-19 2014-10-15 马鞍山市心洲葡萄专业合作社 Pearl health-care powder capable of nourishing liver and improving visual acuity and preparation method thereof
CN104547264A (en) * 2014-12-22 2015-04-29 山东天地健生物工程有限公司 Capsules for improving memory and preparation method thereof
CN104621559A (en) * 2015-01-16 2015-05-20 熊文花 Health product with effects of refreshing brain and improving intelligence and preparation method thereof
CN104621559B (en) * 2015-01-16 2017-05-17 熊文花 Health product with effects of refreshing brain and improving intelligence and preparation method thereof
CN106492038A (en) * 2016-12-13 2017-03-15 蓝庆流 A kind of Chinese medicine composition for strengthening memory

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