CN103719493A - Brain-boosting and intelligence-enhancing sealwort health-care tea and preparation method thereof - Google Patents

Abstract

The invention provides brain-boosting and intelligence-enhancing sealwort health-care tea which comprises the following raw materials in parts by weight: 10-50 parts of sealwort, 10-20 parts of fructus alpiniae oxyphyllae, 10-20 parts of polygala tenuifolia, 10-20 parts of radix rehmanniae preparata, 10-20 parts of angelica sinensis, 10-20 parts of radix curcumae, 10-20 parts of fructus psoraleae, 10-20 parts of poria with hostwood, 10-20 parts of semen juglandis, 10-20 parts of codonopsis pilosula, 10-20 parts of semen biotae, 10-20 parts of astragalus membranaceus, 10-20 parts of prepared fleece flower roots, 10-20 parts of radix paeoniae alba, 10-20 parts of schisandra chinensis, 10-20 parts of rhizoma atractylodis macrocephalae, 10-20 parts of albizia flowers, 10-20 parts of tuber fleeceflower stems, 10-20 parts of rhizoma acori graminei and 10-20 parts of mulberries. The brain-boosting and intelligence-enhancing sealwort health-care tea provided by the invention has the effects of invigorating kidney and nourishing essence, reducing phlegm and inducing resuscitation, boosting brain and enhancing intelligence and promoting blood circulation to dissipate stasis. The brain-boosting and intelligence-enhancing sealwort health-care tea contains neurotrophic factor-like components which can promote repair of memory-related damaged brain tissues caused by vascular factors, so that neurotransmitter AHC secretion is increased, the activity of SOD (Superoxide Dismutase) is improved, and the contents of excitatory amino acids and oxygen radicals in brain tissues are reduced.

Description

Siberian solomonseal rhizome health-care tea of a kind of brain-nourishing intelligence-benefiting and preparation method thereof

Technical field

The present invention relates to contain the benefit brain health-care product that derives from plant composition, particularly Siberian solomonseal rhizome health-care tea of a kind of brain-nourishing intelligence-benefiting and preparation method thereof.

Background technology

Brain worker is more and more now, and many people start to occur overstrain one's nerves symptom, as decrease of memory, thought slowness etc.But, still there are a lot of people overstrain one's nervesly not know for how being only, for overstrain one's nerves harm, also lack understanding.Expert points out, long-term overstrain one's nerves do not note adjustment, the diseases such as possible inducing neural is weak, insomnia.Therefore, should make great efforts the generation of avoiding overstrain one's nerves.About overstrain one's nerves symptom, common are following several:

Feel dizzy, Hearing, auricular concha heating; Limbs fatigue, drowsiness or sleepy; Notice can not be concentrated, decrease of memory, and it is quick, slow in reacting that thinking is owed; There is feeling sick, vomitting phenomenon etc.

Seen above overstrain one's nerves symptom, someone may say, a lot of diseases all may occur these symptoms.So, what in the end be only overstrain one's nerves? expert explains, overstrain one's nerves people, and brain produces fatigue state, show as giddy, headache, dim eyesight, comprehension and decrease of memory, slow in reacting, and a series of syndromes such as study and work Efficiency Decreasing, be called and excessively use brain syndrome.Generally, overstrain one's nerves meeting causes great harm to the physical and mental health of human body, is mainly manifested in following two aspects:

1, physiological function is unbalance: absent minded, can't help give free rein to fancy, attend class wander, thought deserts, thereby affect memory, thinking ability, impact study, sleep rule is undesired, daytime lassitude, attend class easily sleepy, yawn, brain has dizzy spells, after bed at night, brain but psychs up, and thoughts thronging one's mind, are difficult to fall asleep, random dream is diverse and confused, even Morning Has Broken, and after waking up, brain is fatigue especially, is unable to pull oneself together.

2, mental function is unbalance: because the unbalance symptom of above-mentioned all physiological functions is perplexing teenager, cause adolescent psychology function unbalance, show as worry, anxiety, depression, agitation, passiveness, sensitivity, suspicious, feel oneself inferior, feel guilty, thwack spirit on surface, heart is full of puzzled and painful, helpless and know which way to go, then produce be weary of studying, play truant, run away from home, calf love, unmarried sexual behaviour, sexual crime, even produce thoughts of suicide.

Expert emphasizes, the long-term overstrain one's nerves physiology causing and mental function are unbalance, a series of serious phrenoblabia diseases such as possible inducing neural is weak, insomnia.Therefore, for overstrain one's nerves, must not adopt a casual attitude, should be taken precautions against in time.

Sealwort is used as medicine with rhizome.There is boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney benefiting functions.Be used for the treatment of weakness of the spleen and the stomach, fatigue and asthenia, dry food is few, deficiency syndrome of the lung cough caused by dryness, asthenia of essence and blood, the interior heat disease such as quench one's thirst.Very effective in cure for diabetes.Sealwort main product in Hebei, the provinces and regions such as Inner Mongol, Shaanxi Province.David's-harp main product in Guizhou, the province such as Hunan, Yunnan, Anhui, Zhejiang.Yunnan sealwort main product in Guizhou, the provinces and regions such as Guangxi, Yunnan.Property sugariness flat, return spleen; Lung; Kidney channel, is boosting qi and nourishing yin, invigorating the spleen, moistening lung, the good medicine of kidney-nourishing.Curing mainly deficiency of Yin labor coughs; Xeropulmonary cough; Insufficiency of the spleen weak; The few dry of food; Quench one's thirst; Deficiency of the kidney soreness and weakness of waist and knees; Impotence and seminal emission; Tinnitus order is dark; Poliosis; The empty win of body is thin; Wind favus disease.

Sealwort has hypotensive, hypoglycemic, reducing blood lipid, and atherosclerosis, delays senility and effect such as antibacterial grade, and Siberian solomonseal rhizome polysaccharide has Immunestimulatory effect.For the lung-dryness syndrome due to yin deficiency, the few phlegm of dry cough, and the labor of the lung-kidney deficiency chronic cough etc. of coughing.For weakness of the spleen and the stomach.Both tonifying spleen-yin, beneficial temper again, for deficiency of kidney essence, obtain dizzy, soreness and weakness of waist and knees, poliosis and quenching one's thirst etc.The good medicine of nourishing of good moistening lung help.But three minutes poison of medicine, also produce resisting psychology while allowing people's long-term taking.How the efficacy exertion of sealwort not being injured again to human body to maximum, is our problem in the urgent need to address.

Overstrain one's nerves meeting causes vegetative dystonia, thereby causes that cerebrovascular shrink function is abnormal, and the symptoms such as dizziness headache is uncomfortable in chest appear in blood supply insufficiency.According to the blood stasis main blood of liver of touching upon, adjust the theory of blood, adopt promoting blood circulation and removing blood stasis, soothing the liver tune blood (nursing one's health cerebrovascular wall systolic and diastolic function) and reach therapeutic purposes.Sealwort can be used for a long time just and not injure human body, and can obviously improve memory, recovers the good timber of brain nutrition.How to develop the effect of sealwort, be only the direction of our research.

Summary of the invention

Technical problem to be solved by this invention is, modern brain worker is more and more, and many people start to occur overstrain one's nerves symptom, as decrease of memory, thought slowness etc.Overstrain one's nerves meeting causes vegetative dystonia, thereby causes that cerebrovascular shrink function is abnormal, and the symptoms such as dizziness headache is uncomfortable in chest appear in blood supply insufficiency.On market, occur now the health products of various brain-nourishing intelligence-benefitings, great majority are amusements of businessman's false propaganda, there is no what health care at all, also allow people waste wealth.The present invention has tonifying kidney and benefiting sperm, reduce phlegm out steal, brain-nourishing intelligence-benefiting, the effect of invigorating blood circulation addiction.Sealwort galangal fruit health-care tea contains neurotrophic factor sample ingredient, can promote the reparation of the destruction brain tissue relevant to memory that vascular factor causes, and neurotransmitter AHC secretion is increased.Improve SOD active, reduce excitatory amino acid, content of oxygen free radical in brain tissue, suppress the activation of cerebral cortex excitatory amino acid receptor, play nourishing brain cell, protect brain cell, improve brain function, improve cognitive ability.Add some mouthfeels light, do not affect the Chinese medicine of King solomonseal rhizome tea taste, make people be easy to accept, can reach preferably the effect of brain-nourishing intelligence-benefiting.

For solving above-mentioned technical barrier, the invention provides a kind of Siberian solomonseal rhizome health-care tea of brain-nourishing intelligence-benefiting, described in it, the parts by weight of the various raw materials of Siberian solomonseal rhizome health-care tea are: 10～50 parts of sealworts, 10～20 parts of fructus alpiniae oxyphyllaes, 10～20 parts of polygala roots, 10～20 parts, cultivated land, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of root tubers of aromatic turmeric, 10～20 parts of Psoralea corylifolias, 10～20 parts of fushens, 10～20 parts of walnut kernel, 10～20 parts of Radix Codonopsis, 10～20 parts of the seed of Oriental arborvitaes, 10～20 parts of the Radixs Astragali, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of the root of herbaceous peonys, 10～20 parts, the fruit of Chinese magnoliavine, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts of Flos Albiziaes, 10～20 parts of Polygonum multiflower knotweeds, 10～20 parts of grass-leaved sweetflags, 10～20 parts of mulberries.

The Siberian solomonseal rhizome health-care tea of described brain-nourishing intelligence-benefiting, described in it, the parts by weight of the various raw materials of smart health protection tea can be: 10～30 parts of sealworts, 10～15 parts of fructus alpiniae oxyphyllaes, 10～15 parts of polygala roots, 10～15 parts, cultivated land, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of root tubers of aromatic turmeric, 10～15 parts of Psoralea corylifolias, 10～15 parts of fushens, 10～15 parts of walnut kernel, 10～15 parts of Radix Codonopsis, 10～15 parts of the seed of Oriental arborvitaes, 10～20 parts of the Radixs Astragali, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of the root of herbaceous peonys, 10～20 parts, the fruit of Chinese magnoliavine, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts of Flos Albiziaes, 10～20 parts of Polygonum multiflower knotweeds, 10～20 parts of grass-leaved sweetflags, 10～20 parts of mulberries.

The Siberian solomonseal rhizome health-care tea of described brain-nourishing intelligence-benefiting, described in it, the parts by weight of the various raw materials of Siberian solomonseal rhizome health-care tea can also be: 10～40 parts of sealworts, 10～20 parts of fructus alpiniae oxyphyllaes, 10～20 parts of polygala roots, 10～20 parts, cultivated land, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of root tubers of aromatic turmeric, 10～20 parts of Psoralea corylifolias, 10～20 parts of fushens, 10～20 parts of walnut kernel, 10～20 parts of Radix Codonopsis, 10～20 parts of the seed of Oriental arborvitaes, 10～15 parts of the Radixs Astragali, 10～15 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～15 parts of the root of herbaceous peonys, 10～15 parts, the fruit of Chinese magnoliavine, 10～15 parts of the bighead atractylodes rhizomes, 10～15 parts of Flos Albiziaes, 10～15 parts of Polygonum multiflower knotweeds, 10～15 parts of grass-leaved sweetflags, 10～15 parts of mulberries.

For solving the problems of the technologies described above, the invention provides a kind of preparation method of Siberian solomonseal rhizome health-care tea of brain-nourishing intelligence-benefiting, described in it, the preparation process of Siberian solomonseal rhizome health-care tea comprises following aspect:

A. the preparation of sealwort;

B. by described other raw material pulverizing, immersion, heating, refluxing extraction 2 times;

C. the liquid again surplus stock being extracted is condensed into granule, pulvis or paste;

D. concentrated granule, pulvis or paste are mixed with the sealwort preparing, be prepared into health protection tea.

In described step a, the sealwort of results can be cleaned, the airing time, at 7-12 hour, parches; Be cut into thin slice, put a pot interior water proof and steam 30-60 minute at 80-100 ℃, then dry; After drying, repeat again to steam once, dry; Repeat again to steam and shine once; Then put into large iron pan and stir-fry, first downwards backward upper, firmly want evenly, when sealwort color starts blackout, start the moulding in 30-45 minute that stir-fries of little fire; When color becomes pitchy, after taking out, naturally dry.

In described step b, surplus stock can be cleaned to impurity elimination, dry, be ground into particle, soak 1 hour; Soaked raw material is put to boiling secondary in multi-function extractor; Add up for the first time the water of 10 times of amounts of medicinal material, decoct 1.5～2 hours, get decocting liquid, filter; The water that adds for the second time 7 times of amounts of total amount, decocts 1～1.2 hour, gets twice decocting liquid and mixes, and filters.

In described step c, the filtrate of filtration can be inserted in economic benefits and social benefits vacuum concentrator to the concentrate that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Refrigeration liquid is added to 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, convection drying powdered.

In described steps d, the powder that the good sealwort of frying can be prepared with surplus stock mixes, and ultraviolet disinfection, packs and get final product.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method of Siberian solomonseal rhizome health-care tea of brain-nourishing intelligence-benefiting again, and when other raw materials of described Siberian solomonseal rhizome health-care tea are made paste, step is:

A, get bulk drug and put into ethanol and soak, heat is extracted 2 times, becomes paste, is component 1;

B, dregs of a decoction extracting in water 2 times, thickening filtration is paste, is component 2;

C, above-mentioned two kinds of pastes are merged, after ultraviolet radiation for sterilizing and disinfecting, merge packing with the good sealwort of frying.

The preparation method of the Siberian solomonseal rhizome health-care tea of described brain-nourishing intelligence-benefiting, when other raw materials are made paste, in described step a, can get in the ethanol that raw material adds 5-10 doubly to measure and soak 1-2 hour, heating is extracted 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, then through the molecular weight that dams, is the ultrafiltration post ultrafiltration of 5000-10000,1.36 medicinal extract when ultrafiltrate reduced pressure concentration relative density is 80 ℃, heating is concentrated into paste, and stand for standby use, becomes component 1; In described step b, the dregs of a decoction that alcohol extract can be crossed are put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1～2 hour, and 100-120 order filters, then through the molecular weight that dams, is the ultrafiltration post ultrafiltration of 5000-10000,1.36 medicinal extract when ultrafiltrate reduced pressure concentration relative density is 80 ℃, heating is concentrated into paste, and stand for standby use, becomes component 2.

The technique effect that the present invention is useful is, modern brain worker is more and more, and many people start to occur overstrain one's nerves symptom, as decrease of memory, thought slowness etc.Overstrain one's nerves meeting causes vegetative dystonia, thereby causes that cerebrovascular shrink function is abnormal, and the symptoms such as dizziness headache is uncomfortable in chest appear in blood supply insufficiency.On market, occur now the health products of various brain-nourishing intelligence-benefitings, great majority are amusements of businessman's false propaganda, there is no what health care at all, also allow people waste wealth.Sealwort sugariness is flat, returns spleen; Lung; Kidney channel, is boosting qi and nourishing yin, invigorating the spleen, moistening lung, the good medicine of kidney-nourishing.The present invention has tonifying kidney and benefiting sperm, reduce phlegm out steal, brain-nourishing intelligence-benefiting, the effect of invigorating blood circulation addiction.Sealwort galangal fruit health-care tea contains neurotrophic factor sample ingredient, can promote the reparation of the destruction brain tissue relevant to memory that vascular factor causes, and neurotransmitter AHC secretion is increased.Improve SOD active, reduce excitatory amino acid, content of oxygen free radical in brain tissue, suppress the activation of cerebral cortex excitatory amino acid receptor, play nourishing brain cell, protect brain cell, improve brain function, improve cognitive ability.The most mouthfeel of these medicinal materials is light, does not affect the taste of King solomonseal rhizome tea, there is no the unpleasant taste of traditional Chinese medicine of swallowing of being difficult to, and makes people be easy to accept, can long-term taking, more can reach preferably the effect of brain-nourishing intelligence-benefiting.

The specific embodiment

Sealwort is conventional tonic Chinese herbal medicine, in China's medication of existing more than 2000 year history, is Liliaceae Polygonatum herbaceos perennial, medicinal its rhizome.Sealwort is flat, taste is sweet, returns spleen, lung, kidney channel, has the effect of tonifying spleen moistening lung, supplementing qi and nourishing yin, is used for the treatment of the diseases such as body void is weak, palpitation, dryness of the lung dry cough, ringworm of the body.

In recent years, people deepen continuously to the research of sealwort and Polygonatum plant thereof, and from sealwort plant, the separated chemical composition obtaining has alkaloid, flavones, quinones, lignanoid, polysaccharide, steroid saponin and trace element etc.

1, regulate blood sugar effect

Siberian solomonseal rhizome polysaccharide has no significant effect normal mouse blood sugar level, but can significantly reduce the blood glucose value of the hyperglycaemia mouse that adrenaline brings out, reduces the content 8A of CAMP cAMP in adrenaline model mice liver simultaneously:.Normal mouse abdominal cavity gives sealwort methanolic extract 800mg/kg, after 4h, can make blood sugar drop to (144 ± 13) mg/dL from (220 ± 7) mg/dL, the blood sugar that streptozotocin under similarity condition (STZ) brings out hyperglycaemia mouse (insulin-dependent model) drops to (396 ± 15) mg/dL from (589 ± 34) mg/dL, but it does not change serum insulin levels in hypoglycemic activity.This extract suppresses the effect that adrenaline brings out hyperglycaemia mouse blood sugar in addition.Someone obtains 2 active components from its active site separation, through being accredited as spirostanol glycoside.

2, regulate immunization

By high, medium and low dosage Siberian solomonseal rhizome polysaccharide, the impact test of Phagocytosis By The Peritoneal Macrophages In Mice, mouse Hemolysin formation and delayed allergy (DTH) is found, the immunoregulation effect of Siberian solomonseal rhizome polysaccharide clearly, not only can strengthen mouse humoral immune function, also can strengthen the function of mouse cell immunity.Immunocompetence is screened and is shown, sealwort can improve the hemopoietic function of bone marrow that is subject to endoxan processing mouse, makes its leucocyte and erythrocyte number increase, and Micronucleus declines, and the phagocytic function of Turnover of Mouse Peritoneal Macrophages improves.With continuous the feeding of sealwort decocting liquid 0.5g/d, raise 10d to every mouse, result normal mouse plasma cAMP, cyclic guanosine monophosphate (cGMP) content reduce, and especially with cGMP, reduce significantly, and cAMP/cGMP ratio slightly raises (comparing without significant difference with control group); Normal mouse spleen organizes the content of cGMP but obviously to raise.

3, improve learning and memory effect

With saponins of rhizoma polygonati (PTS), to scopolamine, cause the continuous gavage of learning memory disorder model mice, result shows that PTS can obviously improve the learning and memory function of model mice under 400mg/kg dosage.Siberian solomonseal rhizome polysaccharide 200,100, it (is hydergene as positive control that 50mg/kg3 dosage is given the continuous gavage 15d. of old rats respectively, negative control is equivalent distilled water), within after administration the 15th day and the 30th day, with y type labyrinth, carry out learning test, result shows that Siberian solomonseal rhizome polysaccharide can significantly improve old rats learning and memory and memory represents ability, reducing errors number (compares with positive control, Siberian solomonseal rhizome polysaccharide 200mg/kg and 100mg/kg dosage group difference is extremely significantly (P < 0.01) all, 50mg/kg dosage group significant difference (P < 0.05).Give vascular dementia rat models with every 100g body weight 0.5ml gavage 1 week, then with 10% Siberian solomonseal rhizome health-care tea, continue medication 1.5 months and 2.5 months (clothes drink naturally), result shows that Siberian solomonseal rhizome health-care tea has the effect of reinventing synaptic structure and function, improving vascular dementia SD female rats ability of learning and memory.

4, antifatigue effect

Mouse peritoneal injection sealwort solution 12g/kg, can obviously improve mouse hypoxia-bearing capability; With sealwort water decoction 2.55g/kg gavage mouse, can significant prolongation mouse swimming time (P < 0.05).

5, adjust fat effect

With basic, normal, high dosage Siberian solomonseal rhizome polysaccharide, give 30 of the new zealand purebred rabbits (male and female half and half) after High cholesterol diet is fed, result animal used as test sustainer general form and om observation show, Siberian solomonseal rhizome polysaccharide high dose group aortic tunica intima foam cells forms obvious minimizing (P < 0.05), shows that doses Siberian solomonseal rhizome polysaccharide has the effect that reduces hyperlipidemia animal used as test blood fat and the effect that suppresses the formation of endarterium foam cells.In addition, Siberian solomonseal rhizome polysaccharide obviously reduces in Ad model mice liver, the content of cAMP, thereby infer that its hypoglycemic mechanism is to have reduced in liver cell, the content of cAMP, has hindered phosphorylase and has activated and glycogen synthetase inactivation, thereby causes the synthetic acceleration of glycogen, decomposition of glycogen to slow down.Siberian solomonseal rhizome polysaccharide reduces, and the mechanism of cAMP may affect the expression of adrenocepter or cause that the conformational change of acceptor is relevant with it, and this respect also needs further to studies confirm that.

6, delaying senility function

With Siberian solomonseal rhizome health-care tea 0.2, the continuous gavage mouse of 0.4ml/d 4 weeks (making respectively the positive, negative control with American ginseng health tea and water respectively), after swimming 90min, put to death, this health protection tea of result can significantly reduce the heart, liver lipid peroxide LP0) generation P < 0.01, increase glutathione peroxidase activity and blood superoxide dismutase SOD vigor, and be dose dependent; Compare with positive controls, Siberian solomonseal rhizome health-care tea suppresses the heart, liver LPO generative capacity obviously increases, and is also dose dependent, shows that it has anti-ageing anti-old effect.Studied the Antioxidation in vitro of Siberian solomonseal rhizome polysaccharide, result shows that it can suppress generation spontaneous and lipid peroxidation product MDA (MDA) induction in vitro, oxygen radical is had to direct scavenging action, show Siberian solomonseal rhizome polysaccharide anti-oxidant and anti-aging aspect there is certain effect.

Along with progressively going deep into sealwort pharmacology, pharmaceutical chemistry and clinical research, people find and confirm in sealwort plant that steroid saponin and analogous components thereof have some good pharmacologically actives gradually, and existing patent application, as the patents such as " steroid saponin in Chinese medicine sealwort and medical usage thereof and preparation methods " of Lee's milling.Simultaneously, active site based on Polygonatum plant and the research of active ingredient, people are also carrying out New Drug Research, sealwort and glycocalix thereof have been made some Chinese patent drugs evident in efficacy, health products, new antiviral drug, health protection tea, as Siberian solomonseal rhizome polysaccharide eye drops, antiviral Siberian solomonseal rhizome polysaccharide sulfuric ester, Wonderful creme and the spray of prevention and treatment genital herpes, the ancient crane pine health liquor of tool deferring senility, Siberian solomonseal rhizome polysaccharide health protection tea, sealwort radix paeoniae rubrathe parenteral solution, sealwort medicinal extract etc.

All on the books to sealwort in < < Chinese medicine voluminous dictionary > > and pertinent literature: can calm the nerves, the swollen wind pain of lively atmosphere blood, the wide intestines of sending down abnormally ascending, heat-clearing, long-pendingization of dispelling are stagnant, gut purge, ease constipation, invigorating the spleen moistening lung, cough-relieving, relieving asthma, the effect such as anti-inflammatory, antiallergy, cardiac stimulant, invigorating the spleen moistening lung, beauty treatment.Sealwort--seven major nutrient complete set, is not medicine, is not health products, is to work as the food that meal is eaten, and but has remarkable healthy nutritive value and outstanding dietotherapy effect.

The flat taste of the seed of Oriental arborvitae is sweet, the heart, kidney, large intestine channel.Tool mental-tranquilization, the effect relaxing bowel.Control the diseases such as palpitation with fear, insomnia, seminal emission, night sweat, constipation, energy mental-tranquilization, relaxes bowel.For restlessness of asrhenia type and insomnia, palpitation and severe palpitation, intestines are dry makes the secret disease that Dengs.< < medicineization justice > >: the seed of Oriental arborvitae, the saturating heart of fragrance, body profit is grown blood.Same fushen, jujube kernel, the dried rhizome of rehmannia, the tuber of dwarf lilyturf, for clear product in turbid, cure mainly mind void timid, palpitates with fear the second month in a season seized with terror, and color is wan and sallow, and skin is dry itches, and the merit of the blood that all nourishes heart also.Get again smell all dense, return kidney in turbid, same cultivated land, tortoise version, matrimony vine, the root of bidentate achyranthes, for packing marrow, cure mainly damage of kidney-YIN, back grave illness, and sufficient knee is weak, night sweat due to yin deficiency, all the dry power of nourshing kidney is also.Taste is sweet also can delay liver, and the deficiency of tonifying liver courage is extremely reliable, but the flat power of property is slow, should be multiplex be wonderful.

Polygala root is bitter, pungent, tepor.The thoughts of returning home, kidney, lung channel.Function cures mainly the intelligence development of calming the nerves, eliminates the phlegm, and detumescence.The insomnia and dreamful sleep causing for breakdown of the normal physiological coordination between the heart and the kidney, forgetful palpitation with fear, wandering, expectoration is not well, sore swollen toxin, mastosis.Be applied to insomnia and dreamful sleep, palpitation and severe palpitation, forgetful.This product toil is warm in nature, property is kind lead off sensible, happily gas and antitoxic heart-soothing and sedative, can lead to kidney qi and strong will is not forgotten, be restoring normal coordination between heart and kidney, stable mind, the intelligence development good merchantable brand of knowledge by force.Cure mainly the diseases such as the having no peace of mind of breakdown of the normal physiological coordination between the heart and the kidney, insomnia, palpitation with fear, the same use of medicinal for tranquilizing mind such as normal and fushen, dens draconis, cinnabar, as polygala root ball (< < Zhang Shi doctor is led to > >); Control forgetful card, normal and ginseng, Poria cocos, calamus are used together, as Kaixin San (< < prescriptions worth thousand gold > >), if Fang Zhongzai adds fushen, (< < Standards of Diagnosis and Treatment > >) do not forget to fall apart.The positive > > of < < book on Chinese herbal medicine: polygala root, the wholwe-hearted kidney of merit, therefore can only shy by relieving palpitation the peace that exorcises evil spirits dream, Yang strengthening and life essence tonifying, strong will power-assisted.With its gas lift, therefore same ginseng, Radix Glycyrrhizae, jujube kernel, the utmost point can be lifted to fall into and take the photograph essence, handing-over extreme misery.

The Chinese medicine fleece-flower root have Radix Polygoni Multiflori and RADIX POLYGONI MULTIFLORI PREPARATA minute, direct slicing is used as medicine for Radix Polygoni Multiflori, with black soya bean liquor, mixes after steaming and dries and be used as medicine for RADIX POLYGONI MULTIFLORI PREPARATA.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, the carbuncle that disappears, relax bowel, be usually used in treating scrofula sore carbuncle, rubella itch, the dry constipation of intestines; The filling liver kidney of RADIX POLYGONI MULTIFLORI PREPARATA function, benefiting essence-blood, black beard and hair, strengthening the bones and muscles, under sallow, the dizzy tinnitus of the deficiency of blood, poliosis, soreness and weakness of waist and knees, extremity numbness, uterine bleeding band, chronic malaria body void etc.RADIX POLYGONI MULTIFLORI PREPARATA of the present invention is the good merchantable brand of invigrating kidney.

Cortex albiziae nature and flavor are sweet, flat.The merit that has Xie Yu and blood, the peaceful heart, subduing inflammation.Have control that confused and worried, melancholy, insomnia, lung carbuncle, carbuncle are swollen, the effect of scrofula, injured bone.The < < book on Chinese herbal medicine > > that looks for the truth: " cortex albiziae.Why silk tree is named, and the internal organs peace of its clothes is supported, and makes us joyous happy, therefore with joyous name.< < herbal classic > >: main five viscera settling, and will, make us happy carefree.Be usually used in the unsuccessful melancholy of feelings will and induced insomnia person, have no peace of mind etc. under, clinically manyly join with the seed of Oriental arborvitae, the heart, spina date seed is equal to use, to strengthen strongly fragrant, the tranquilizing the mind effect of nourishing heart out.

Walnut kernel nature and flavor are sweet, temperature.Return kidney, lung, large intestine channel.Kidney tonifying, warm lung, ease constipation.For soreness and weakness of waist and knees, impotence and seminal emission, the cold of insufficiency type is breathed heavily and is coughed, constipation.Brain tonic is anti-old: walnut kernel contains more protein and the essential unrighted acid of human nutrition, and these compositions are all the important substance of cerebral tissue cellular metabolism, can nourish brain cell, strengthens brain function.

Fushen's taste is sweet, light, property is flat, be used as medicine there is clearing damp and promoting diuresis, the function of beneficial spleen and stomach, antitoxic heart-soothing and sedative.Nature and flavor are sweet, light flat.There are the functions such as excreting dampness, invigorating the spleen, Ning Xin.For phlegm and retained fluid, oedema, difficult urination, have loose bowels, palpitaition, dizzy.Fuling peel, inducing diuresis for removing edema, for diseases such as the wet edema of water, for having a guilty conscience palpitation with fear, forgetful, insomnia, frightened epilepsy, difficult urination.< < does not record > >: treat wind dizzy, wind is empty, the exhaustion or lesion of the five internal organs, dry.Only palpitation with fear, is enraged more, forgetful.Happy intelligence development, supports spirit.

The Radix Astragali has the effects such as invigorating qi for strengthening superficies, sharp water detumescence, pus draining and toxin expelling, myogenic.The medicinal history of existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing various trace elements such as saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhanced machine body immunity function, protect the liver, diuresis, anti-ageing, anti-stress, step-down and antibacterial action more widely.But table is real evil, contain, retention of dampness due to stagnation of QI, dyspepsia is stagnated, ulcer from the beginning of or the real example such as routed after heat poison Shang Sheng.The Radix Astragali has invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, the effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, the uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult bursts, and bursts and does not hold back for a long time, and the deficiency of blood is sallow, and interior heat is quenched one's thirst.< < herbal classic > > records: " main ulcer, loses sore for a long time, apocenosis pain relieving.Qi-restoratives, children's's all kinds of diseases and ailments." < < Japan hanako materia medica > > record: " help gas to strengthen the bone, put on flesh and enrich blood.”

Mulberries: nourishing yin and nourishing blood medicine; Medicine promotes the production of body fluid; Aperitive.Modern study confirms, in mulberries fruit, contain the compositions such as abundant activated protein, vitamin, amino acid, carrotene, mineral matter, resveratrol, anthocyanidin, nutrition is 5～6 times of apple, 4 times of grape, there is multiple efficacies, by medical circle, be described as " the best health fruit of 21st century ".Often eat mulberries and can significantly improve body immunity, have and delay senility, the effect of beautifying face and moistering lotion.Traditional Chinese medicine thinks that mulberry fruit taste is sour, cold nature, have improve body immunity, the enriching yin of enriching blood, promote the production of body fluid to quench thirst, the effect such as dry is dispelled in ease constipation, cure mainly deficiency of YIN-blood and having a dizzy spell of causing, tinnitus palpitaition, irritated insomnia, soreness and weakness of waist and knees, poliosis, quench one's thirst that only dry, dry and hard excrement, nourishing yin and supplementing blood, improving eyesight are calmed the nerves, sharp joint, curing rheumatism, the effect such as relieve the effect of alcohol.

Radix Angelicae Sinensis, its taste is sweet and weigh, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting circulation of blood, bowl spares has, in row, has benefit, really the gas medicine in blood, the also panacea in blood.About mending to mend of assistant, thus can support nutrition blood, tonifying Qi production of sperm, five viscera settling, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack, therefore the pain defaecation of dispelling, relieving rigidity of muscles and joints, controls contraction, paralysis, the card such as dry, puckery.Seek void and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and table is not held back person, and assistant, with rheum officinale and so on, can be shown again admittedly.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

The root of herbaceous peony enters liver, the spleen channel, nourishing blood and liver, and slow middle pain relieving, astringe yin is received sweat.Control chest abdomen pain over the hypochondriac region, rush down dysentery stomachache, spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, under band, married woman's blood closes obstructed, and the hemostasis that disappears can lose purulence, beneficial woman's blood.< < Japan hanako materia medica > >: control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, logical month water, brings down a fever, relieving restlessness, benefit gas, the hot disease of it row, pest miasma, frightened mad, married woman's blood fortune, and intestines wind, rush down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, sore scabies, headache, improving eyesight, hot eyes is exerted meat.The many tonifying Qi of redness of the skin or complexion person, white person controls blood.

Cultivated land has another name called prepared rhizome of rehmannia or throws oneself on the ground, belong to goatweed, be a kind of first-class Chinese medicine, there is the enriching yin of enriching blood effect, can be used for the deficiency of blood sallow, dizzy, palpitation and insomnia, irregular menstruation, the diseases such as uterine bleeding, also can be used for hectic fever hectic fever due to yin, the night sweat of the deficiency of the kidney yin, the disease such as pass out semen, quench one's thirst, is one of asthenic symptoms class non-prescribed medicine medicine Liuwei Dihuang Wan main component.This quality is moistened into kidney, kind nourishing kidney yin, and life essence-filling, marrow-benefitting, is the key medicine of tonifying kidney-yin.Ancients call it " large tonifying five zang organs is Kidney-Yin ", " mending greatly true water ".Normal be equal to use with Chinese yam, Fructus Corni, treat the deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, seminal emission, night sweat, tinnitus, deafness and quench one's thirst etc., can filling liver kidney, and beneficial marrow, as Liuwei Dihuang Wan.

Flos Albiziae contains silk tree glucoside, tannin, and resolving stagnation for tranquilization, the appetizing of regulating the flow of vital energy, activating collaterals to relieve pain, for confused and worried, melancholy insomnia.Control pent-up uncomfortable in chest, insomnia, forgetful, acute conjunctivitis, can five viscera settling, and will, happy color, have preferably keep fit, calm, the effect of calming the nerves, improve looks, be also to treat neurasthenic good merchantable brand.Also there is clearing away summerheat, the face-beautifying and spot-removing effect such as relieve the effect of alcohol.< < book on Chinese herbal medicine is said through > >: " Flos Albiziae energy five viscera settling, and will, happy color." especially to pregnant woman, have preferably keep fit, calm, the effect of calming the nerves, improve looks, be also to treat neurasthenic good merchantable brand.

Fruit of Chinese magnoliavine temperature; Sour, sweet; Return lung, the heart, kidney channel; Restrain astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney calming.For the void of coughing for a long time, breathe heavily, emission, enuresis frequent micturition, endless diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the feeble pulse of losing heart, interior heat is quenched one's thirst, palpitation and insomnia.< < Bencao Jingshu > > carries: the main beneficial gas person of the fruit of Chinese magnoliavine, and all gas of lung master, acid can be received, and is just entering lung tonifying lung, therefore beneficial gas is also.Its main cough with dyspnea person, the deficiency of vital energy is above stopped up and is not returned unit, and sour flavor having the property of astringing, takes the photograph gas and returns unit, and cough with dyspnea is from removing.Internal lesion caused by overexertion is won thin, tonifying for the deficiency, reinforcing yin essence, beneficial man's essence.< < does not record > > and supports the five internal organs, heat extraction, flesh person in raw the moon, the special kidney tonifying of the fruit of Chinese magnoliavine, the tonifying five zang organs of holding concurrently, kidney storing essence, essence is contained cloudy strong, receipts are taken the photograph vital qi and are returned unit, and public region is warm, digesting food, steam waste matter and change precise and tiny, smart spontaneous, essence is raw cloudy long, therefore main as above all diseases also.

Polygonum multiflower knotweed is nourished heart, and calms the nerves, and dredging collateral, dispels the wind, and the traditional Chinese medical science thinks, Polygonum multiflower knotweed property is flat nontoxic, and sweet and slightly bitter taste, enters the heart, Liver Channel, has the effect of tranquilizing and blood nourishing, dispelling wind and removing obstruction in the meridians, cures mainly the diseases such as deficiency of Yin blood is few, restlessness of asrhenia type and insomnia, arthralgia due to wind-dampness, itchy skin eruption.Compatibility of drugs: complex acid jujube kernel, grow the heart-yin, the peaceful mind; Join the dried rhizome of rehmannia, the tonifying yin of nourishing blood; Join lucid asparagus, the tuber of dwarf lilyturf, the clear fire of deficiency type, the moon nourishes heart; Join notopterygium root, levisticum, expelling wind and eliminating dampness, Shu Li joint.

Fructus alpiniae oxyphyllae taste is pungent; Warm in nature.Temperature kidney controlling nocturnal emission with astringent drugs contracting urine, warm spleen appetizing is taken the photograph phlegm temperature compensation and is admittedly taken the photograph, warm spleen antidiarrheal ， Gu Dan takes the photograph saliva, warm kidney controlling nocturnal emission with astringent drugs contracting urine, cure mainly spleen suffer from a deficiency of the kidney cold, abdominal pain diarrhea; Or kidney qi cold of insufficiency type frequent urination, the enuresis, seminal emission, gonorrhoea; Or the chronic diarrhea due to deficiency-cold in spleen and stomach and mouthful in saliva outflow and can not effector.The methanolic extract of intelligent promoting fruit has the activity that strengthens guinea pig left atrium convergent force, its minimum effective dose is that 10-6g/m1. reporter thinks, the cardiotonic of yakuchinone first, in part because it is to due to the inhibition of sodium potassium pump in cardiac muscle. No. 1, intelligence development is (by the fleece-flower root, grass-leaved sweetflag, the root of kudzu vine, ginkgo leaf, Ligusticum wallichii, the compositions such as the radix paeoniae rubrathe) memory dysfunction causing because of five kinds of different chemicals is improved to effect. with No. 1 25g/kg of intelligence development, 50g/kg was to mouse stomach 7 days, the destruction that energy antagonism scopolamine 0.001g/kg and yellow Jackets 0.03g obtain memory, improving memory that chloramphenicol 0.2g/kg and natrium nitrosum 0.12g/kg cause consolidates bad and improves the memory that 40% ethanol causes and lack, compare there was no significant difference with piracetam control group.

Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body.Baizhu volatile oil has inhibitory action to mouse EC, lymphosarcoma ascitic type, the cancer of the esophagus (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also there is remarkable inhibitory action.< < property of medicine opinion > > carries it: monarch, taste is sweet, pungent, nontoxic.Can main large wandering arthritis, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken place food that disappears, appetizing, removes sputum, except fever and chills, lets out under only.Interarea light is happy, preserves youthful looks, and de-black.The swelling of harnessing the river is full, tells to vomit contraryly, and crymodynia in abdomen, vomits and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.

Grass-leaved sweetflag is pungent, bitter, temperature.The thoughts of returning home, stomach warp.Dampness elimination appetizing, the open-minded phlegm of having one's ideas straightened out, inducing resuscitation intelligence development.Not hungry for gastral cavity ruffian, mouthful diarrhea of keeping silent, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, coma due to blocking of the respiratory system, pyreticosis coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, wind-cold-dampness arthralgia, swollen ulcer drug, traumatic injury.< < herbal classic > >: " main wind-cold-dampness arthralgia, cough with dyspnea, happy hole, tonifying five zang organs, logical nine orifices, improve visual and auditory acuity, goes out speech." < < does not record > >: " main deafness, carbuncle sore, warming intestines and stomach, stops little facility, and four limbs arthritis with fixed pain caused by dampness must not be bent and stretched, children's's a kind of malaria, body accumulated heat is not understood, and can bathe soup.Clever knowledge, beneficial intelligence.

Psoralea corylifolia taste is pungent; Bitter; Warm in nature.Tonify the kidney and support yang; Promoting inspiration to relieve asthma; Warming spleen and stopping diarrha.The main insufficiency of the kidney yang; Below element deficiency and cold; Waist knee crymodynia; Impotence and seminal emission; Frequent micturition; The enuresis; The failure of the kidney in receiving air; Void is breathed heavily incessantly; Speen-kidney dificiency; Stool is rushed down for a long time; Outward for leucoderma; Alopecia areata; Psoriasis.Psoralea corylifolia and fructus alpiniae oxyphyllae, be all the ripening fruits of plant, is the warm kidney of warm spleen.Yet the large wet of Psoralea corylifolia is thick, taste is held concurrently bitter, thus relatively go down, the kind fire from the gater of life of mending, with kidney-Yang invigorating, cold person is used for suffering from a deficiency of the kidney; It is pungent that the thinner taste of fructus alpiniae oxyphyllae gas is stewed, thus in being partial to and, kind warm spleen soil, help the foundation of acquired constitution, is used for insufficiency of the spleen cold person.< < Compendium of Materia Medica > >: control the kidney type diarrhea, the logical gate of vitality, warm public region, holds back spirit.

Specific embodiment 1:

First, by sealwort preparation, stir-fry.

Again by all the other raw materials tubers of dwarf lilyturf, fructus alpiniae oxyphyllae, polygala root, cultivated land, Radix Angelicae Sinensis, root tuber of aromatic turmeric, Psoralea corylifolia, fushen, walnut kernel, Radix Codonopsis, the seed of Oriental arborvitae, the Radix Astragali, RADIX POLYGONI MULTIFLORI PREPARATA, the root of herbaceous peony, the fruit of Chinese magnoliavine, the bighead atractylodes rhizome, Flos Albiziae, Polygonum multiflower knotweed, grass-leaved sweetflag, mulberries, extract concentrated granulation agent, pulvis or paste.

The sealwort that mixing has been fried and the extract of other raw materials, ultraviolet radiation for sterilizing and disinfecting pack, directly can take after mixing it with hot water during use.

Specific embodiment 2:

Get sealwort 5000g and clean, get the sealwort obtaining and clean, the airing time, at 7-12 hour, parches; Be cut into thin slice, put a pot interior water proof and steam 30-60 minute at 80-100 ℃, then dry; After drying, repeat again to steam once, dry; Then take after mixing it with water to steam and shine once; Then put into large iron pan and stir-fry, first downwards backward upper, firmly want evenly, when sealwort color starts blackout, start the moulding in 30-45 minute that stir-fries of little fire; When color becomes pitchy, after taking out, naturally dry; By surplus stock fructus alpiniae oxyphyllae 1500g, polygala root 1500g, cultivated land 1500g, Radix Angelicae Sinensis 1500g, root tuber of aromatic turmeric 1500g, Psoralea corylifolia 1500g, fushen 1500g, walnut kernel 1500g, Radix Codonopsis 1500g, seed of Oriental arborvitae 1500g, Radix Astragali 1500g, RADIX POLYGONI MULTIFLORI PREPARATA 1500g, root of herbaceous peony 1500g, fruit of Chinese magnoliavine 1500g, bighead atractylodes rhizome 1500g, Flos Albiziae 1500g, Polygonum multiflower knotweed 1500g, grass-leaved sweetflag 1500g, mulberries 1500g.Clean impurity elimination, dry, be ground into particle, soak 1 hour; Soaked bulk drug is put to boiling secondary in multi-function extractor; Add up for the first time the water of 10 times of amounts of medicinal material, decoct 1.5～2 hours, get decocting liquid, filter; Add up for the second time the water of 7 times of amounts of medicinal material, decoct 1～1.2 hour, get twice decocting liquid and mix, filter; The filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator to the concentrate that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Refrigeration liquid is added to 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, adds the agent of dextrin granulation.The sealwort of having fried is mixed with the granule of making, ultraviolet disinfection, packs and get final product again.

Specific embodiment 3:

Get sealwort 4000g and clean, get the sealwort obtaining and clean, the airing time, at 7-12 hour, parches; Be cut into thin slice, put a pot interior water proof and steam 30-60 minute at 80-100 ℃, then dry; After drying, repeat again to steam once, dry; Then take after mixing it with water to steam and shine once; Then put into large iron pan and stir-fry, first downwards backward upper, firmly want evenly, when sealwort color starts blackout, start the moulding in 30-45 minute that stir-fries of little fire; When color becomes pitchy, after taking out, naturally dry; By surplus stock fructus alpiniae oxyphyllae 1200g, polygala root 1200g, cultivated land 1200g, Radix Angelicae Sinensis 1200g, root tuber of aromatic turmeric 1100g, Psoralea corylifolia 1200g, fushen 1200g, walnut kernel 1300g, Radix Codonopsis 1100g, seed of Oriental arborvitae 1200g, Radix Astragali 1200g, RADIX POLYGONI MULTIFLORI PREPARATA 1100g, root of herbaceous peony 1200g, fruit of Chinese magnoliavine 1200g, bighead atractylodes rhizome 1100g, Flos Albiziae 1100g, Polygonum multiflower knotweed 1200g, grass-leaved sweetflag 1200g, mulberries 1200g, puts it in 10 times of water gagings and soaks.Drop into multi-function extractor and extract twice, add for the first time 8-10 times of water gaging and decoct 1-2 hour, add for the second time 4-8 times of water gaging and decoct 1-2 hour, merge twice decocting liquid, filter to get filtrate; Heating is concentrated into powder, then puts into baking oven inner drying powdered, and hybrid packed with the good sealwort of frying after ultraviolet radiation for sterilizing and disinfecting, during use, direct boiling water is taken after mixing it with water.

Specific embodiment 4:

Get sealwort 3500g and clean, get the sealwort obtaining and clean, the airing time, at 7-12 hour, parches, be cut into thin slice, put a pot interior water proof and steam 30-60 minute at 80-100 ℃, then dry, after drying, repeat again to steam once, dry, then take after mixing it with water to steam and shine once, then put into large iron pan and stir-fry, first downwards backward upper, firmly want evenly, when sealwort color starts blackout, start the moulding in 30-45 minute that stir-fries of little fire, when color becomes pitchy, after taking out, naturally dry, by surplus stock fructus alpiniae oxyphyllae 1200g, polygala root 1200g, cultivated land 1200g, Radix Angelicae Sinensis 1100g, root tuber of aromatic turmeric 1100g, Psoralea corylifolia 1200g, fushen 1200g, walnut kernel 1200g, Radix Codonopsis 1100g, seed of Oriental arborvitae 1200g, Radix Astragali 1200g, RADIX POLYGONI MULTIFLORI PREPARATA 1200g, root of herbaceous peony 1200g, fruit of Chinese magnoliavine 1200g, bighead atractylodes rhizome 1200g, Flos Albiziae 1100g, Polygonum multiflower knotweed 1200g, grass-leaved sweetflag 1100g, mulberries 1200g, in the ethanol that adds 5-10 doubly to measure, soak 1-2 hour, heating is extracted 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 medicinal extract when ultrafiltrate reduced pressure concentration relative density is 80 ℃, heating is concentrated into paste, stand for standby use, become component 1, the dregs of a decoction of again alcohol extract being crossed are put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1～2 hour, 100-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 medicinal extract when ultrafiltrate reduced pressure concentration relative density is 80 ℃, heating is concentrated into paste, stand for standby use, become component 2, merge component 1 and component 2 paste making agents, merge the sealwort of having fried, pack.

Pharmacology toxicity test

Experimental example 1: acute toxicity test of the present invention

One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixes decoction 2 times, merges and filters, taking liquid) is containing 0.0365mg/ml.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, 10 every group, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of the maximum permission capacity of mouse, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose is measured (MTD value): get 20 of mouse, each 10 of male and female.Adding distil water of the present invention is dissolved, be made into maximum concentration, by the maximal tolerance dose of animal, to inject, fill with hello device and can twitch and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice (interval half an hour) in a day, each 0.5ml (every ml is containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.After administration, Continuous Observation is 7 days.

Three, result of the test:

In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, do not measure LD50, ask only maximum tolerated dose, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normally, there are no death.Select 300 times of doses that are equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give the present invention by the disposable gavage of small white mouse, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicinal powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation is 7 days, and none example is dead.Medicinal powder dosage is > 42g/kg. day (every g medicinal powder is equivalent to 10g crude drug), by kg body weight, calculate the clinical consumption per day that is equivalent to be grown up 420 times.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give respectively rat the present invention and raise clothes, by adult 70 times of clinical consumption per day and 35 times (being 7g/kg/ day and 3.5g/kg/ day), to give and feed 8 weeks continuously, the behavior, feed, the body weight that have no rat occur extremely, with control group ratio, routine blood test, hepatic and renal function, various important organs are all without abnormal change, within the scope of institute's dosage, do not found any toxicity of the present invention.Acute and chronic toxicity test by animal confirms, safe range of the present invention is larger, is a kind of safe and reliable health products.

Pharmacological experiment:

With saponins of rhizoma polygonati (PTS), to scopolamine, cause the continuous gavage of learning memory disorder model mice, result shows that PTS can obviously improve the learning and memory function of model mice under 400mg/kg dosage.Huang Fang etc. are with Siberian solomonseal rhizome polysaccharide 200, 100, it (is hydergene as positive control that 50mg/kg3 dosage is given the continuous gavage 15d. of old rats respectively, negative control is equivalent distilled water), within after administration the 15th day and the 30th day, with y type labyrinth, carry out learning test, result shows that Siberian solomonseal rhizome polysaccharide can significantly improve old rats learning and memory and memory represents ability, reducing errors number (compares with positive control, Siberian solomonseal rhizome polysaccharide 200mg/kg and 100mg/kg dosage group difference is extremely significantly (P < 0.01) all, 50mg/kg dosage group significant difference (P < 0.05) gives vascular dementia rat models with every 100g body weight 0.5ml gavage 1 week, then with 10% Siberian solomonseal rhizome health-care tea, continue medication 1.5 months and 2.5 months (clothes drink naturally), result shows that Siberian solomonseal rhizome health-care tea has the synaptic structure of reinventing and function, improve the effect of vascular dementia SD female rats ability of learning and memory.

Clinical testing:

1 data and method

1.1 case selections by single random pair grouping in even-numbered days, adopt single blind method to the vascular dementia of being in hospital (hereinafter to be referred as V D) patient 120 examples.

Treatment group 60 examples, male 37 examples wherein, female's 23 examples.Minimum 47 years old of age, maximum 83 years old, 63.52 years old mean age.Mild dementia 37 examples, moderate 17 examples, severe 6 examples.

Control group 60 examples, male 36 examples wherein, female's 24 examples, minimum 46 years old of age, maximum 82 years old, 62.95 years old mean age.Mild dementia 39 examples, moderate 15 examples, severe 6 examples.Two groups all meet " International Classification of Disease 10th edition diagnostic criteria " (CIM10) and the diagnostic criteria of the vascular dementia that NINDS mono-A IR E N1993 works out.Aspect age, sex, simple intelligent scale (MMSE) integration, daily living measuring scale (ALD) integration, learning by statistics processing there was no significant difference.

1.2 methods for the treatment of control groups: add CDPC 1g, vitamin C 3g with physiological saline 250m l; Compound mulberries 20ml in 5% glucose 25Oml (diabetic's physiological saline), quiet, every day 1 time.4 of placebo homotype capsules, oral, every day 3 times, altogether 21d.Oral Nimodipine of while, vitamin E.

Treatment group: use sealwort galangal fruit health-care tea of the present invention, side uses: sealwort 35g, fructus alpiniae oxyphyllae 10g, polygala root 12g, cultivated land 13g, Radix Angelicae Sinensis 12g, root tuber of aromatic turmeric 10g, Psoralea corylifolia 10g, fushen 10g, walnut kernel 10g, Radix Codonopsis 11g, seed of Oriental arborvitae 10g, Radix Astragali 10g, RADIX POLYGONI MULTIFLORI PREPARATA 11g, root of herbaceous peony 12g, fruit of Chinese magnoliavine 12g, bighead atractylodes rhizome 11g, Flos Albiziae 12g, Polygonum multiflower knotweed 12g, grass-leaved sweetflag 11g, mulberries 10g, make tea-drinking bag, oral, every day 3 times, altogether 21d.

1.3 two groups of efficacy determinations treatment front and back and group ask that MMSE, ADL integration carry out statistical analysis comparison.Effective: subjective symptoms obviously alleviates or disappears, MMSE integration improves 5 minutes or approaches normally, and A D L integration declines more than 10 minutes or approaches normal.

Effective: partial symptoms alleviates, M MS E integration improves more than 3 minutes, and A D L integration declines more than 5 minutes.

Invalid: symptom is unchanged, MMSE integration improved not as good as 3 minutes, and ADL integration declined not as good as 5 minutes.

Worsen: aggravation, MMSE integration declines more than 3 minutes, and ADL integration improves more than 5 minutes.

2 results

Before and after 2.1 Different Culture degree treatments, MMSE integration changes in Table 1.

MMSE integral contrast (X ± S) before and after the treatment of table 1 Different Culture degree

Treatment group is better than control group, has significant difference (* P < 0.05, * * P < 0.01).

Treatment group middle and primary schools are better than illiteracy's group (P < 0.05) above.

Before and after 2.2 different sexes treatments, ADL integration changes in Table 2.

ADL integral contrast (X ± S) before and after the treatment of table 2 different sexes

Treatment group is better than control group, has significant difference (* P < 0.05, * * P < 0.01).

In treatment group, the male sex is better than women, has significant difference (P < 0.05).

After 2.3 age groups treatments, general curative effect is relatively in Table 3.

General curative effect comparison after the treatment of table 3 age groups

With the comparison of age group obvious effective rate, treatment group is better than control group, has significant difference (P < 0.05); Obvious effective rate comparison in treatment group, 60 years old following group be better than 61 years old above group, have significant difference (P < 0.05); Total effective rate comparison, treatment group is better than control group (P < 0.05).

3 discuss

V D be take cognition dysfunction as main dementia due to what ischemic or hemorrhagic cerebrovascular disease and full brain ischemia, anoxic caused.Along with the cerebrovascular incidence of disease raises and China's population aging, the incidence of disease of VD has ascendant trend year by year.How to stop the development of VD, this be at present, doctor need to study even from now on emphasis problem.

Theory of traditional Chinese medical science is thought: VD disease is positioned at brain, with liver, the heart, spleen, the substantial connection of having suffered from a deficiency of the kidney, its interpretation of the cause, onset and process of an illness is short mainly due to kidney essense, brain is not filled, the turbid resistance of extravasated blood phlegm is closed brain and is stolen, and brains lose due to moisten and support. and this research be take theory of traditional Chinese medical science as basic, in conjunction with the modern medicine cause of disease, the interpretation of the cause, onset and process of an illness, the galangal fruit health-care tea that the 10 taste Chinese medicines such as the sealwort, grass-leaved sweetflag, polygala root of development form, there is tonifying kidney and benefiting sperm, reduce phlegm out steal, brain-nourishing intelligence-benefiting, the effect of invigorating blood circulation addiction.

From modern medical theory, say there is anti-ischemic, anoxic brain damage and improve cognitive function.VD is mainly because cerebrovascular factor causes and the brain tissue structural deterioration of remembering, intelligence is relevant, cause and the relevant neurotransmitter Ach of memory reduces, oxygen radical, excitatory amino acid, calcium overload have also played certain effect in the generation of V D and progress in addition.

Sealwort galangal fruit health-care tea may contain neurotrophic factor sample ingredient, can promote the reparation of the destruction brain tissue relevant to memory that vascular factor causes, and neurotransmitter A ch secretion is increased.Improve SOD active, reduce excitatory amino acid, content of oxygen free radical in brain tissue, suppress the activation of cerebral cortex excitatory amino acid receptor, play nourishing brain cell, protect brain cell, improve brain function, improve cognitive ability.As shown in Table 1: treatment group is better than control group, there is significant difference (P < 0.05), and find that the improvement of cognitive function is relevant with VD patient's schooling, primary school's culture weak effect, there is statistical significance (P < 0.05), may be less with primary school culture nerve synapse, poor to the sensitiveness of medicine, neurotransmitter secretion, the recovery of propagation function may need the time of more growing.

Cerebral hypoxia ischemia is many because brain blood circulatory disorder causes, therefore invigorating blood circulation trace, improving brain blood circulation is a kind of important measures of correcting cerebral ischemia, anoxic.To delay ischemic, lack foster encephaloclastic chain reaction, thus protection brain cell.Brain-nourishing intelligence-benefiting capsule contains brain circulation promoter sample ingredient, by invigorating blood circulation small house, improves brain blood circulation, promotes brain function to recover, and improves the damaged of nervous function, improves activity of daily living.As shown in Table 2, treatment group is better than control group, has significant difference (p < 0.05).And the treatment group male sex is better than women, there is significant difference (p < 0.05).Women's group effect sees, may be ill easily sentimental with women, be bad at mental activity and physical exertion is relevant, and also may women relevant not as good as male sex's sensitivity to brain blood circulation promoter sample substance reaction.

Sealwort galangal fruit health-care tea can improve the cognitive ability of VD, improves activity of daily living, for family and society have alleviated burden.Any bad reaction is not found in this research of side effect in whole therapeutic process.None example occurs to worsen or is dead.Electrocardiogram, liver function, kidney merit treatment before and after look result contrast not statistically significant.

Claims (10)

1. the Siberian solomonseal rhizome health-care tea of a brain-nourishing intelligence-benefiting, it is characterized in that, the parts by weight of the various raw materials of described Siberian solomonseal rhizome health-care tea comprise: 10～50 parts of sealworts, 10～20 parts of fructus alpiniae oxyphyllaes, 10～20 parts of polygala roots, 10～20 parts, cultivated land, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of root tubers of aromatic turmeric, 10～20 parts of Psoralea corylifolias, 10～20 parts of fushens, 10～20 parts of walnut kernel, 10～20 parts of Radix Codonopsis, 10～20 parts of the seed of Oriental arborvitaes, 10～20 parts of the Radixs Astragali, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of the root of herbaceous peonys, 10～20 parts, the fruit of Chinese magnoliavine, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts of Flos Albiziaes, 10～20 parts of Polygonum multiflower knotweeds, 10～20 parts of grass-leaved sweetflags, 10～20 parts of mulberries.

2. the Siberian solomonseal rhizome health-care tea of brain-nourishing intelligence-benefiting according to claim 1, it is characterized in that, the parts by weight of the various raw materials of described smart health protection tea are: 10～30 parts of sealworts, 10～15 parts of fructus alpiniae oxyphyllaes, 10～15 parts of polygala roots, 10～15 parts, cultivated land, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of root tubers of aromatic turmeric, 10～15 parts of Psoralea corylifolias, 10～15 parts of fushens, 10～15 parts of walnut kernel, 10～15 parts of Radix Codonopsis, 10～15 parts of the seed of Oriental arborvitaes, 10～20 parts of the Radixs Astragali, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of the root of herbaceous peonys, 10～20 parts, the fruit of Chinese magnoliavine, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts of Flos Albiziaes, 10～20 parts of Polygonum multiflower knotweeds, 10～20 parts of grass-leaved sweetflags, 10～20 parts of mulberries.

3. the Siberian solomonseal rhizome health-care tea of brain-nourishing intelligence-benefiting according to claim 1, it is characterized in that, the parts by weight of the various raw materials of described Siberian solomonseal rhizome health-care tea are: 10～40 parts of sealworts, 10～20 parts of fructus alpiniae oxyphyllaes, 10～20 parts of polygala roots, 10～20 parts, cultivated land, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of root tubers of aromatic turmeric, 10～20 parts of Psoralea corylifolias, 10～20 parts of fushens, 10～20 parts of walnut kernel, 10～20 parts of Radix Codonopsis, 10～20 parts of the seed of Oriental arborvitaes, 10～15 parts of the Radixs Astragali, 10～15 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～15 parts of the root of herbaceous peonys, 10～15 parts, the fruit of Chinese magnoliavine, 10～15 parts of the bighead atractylodes rhizomes, 10～15 parts of Flos Albiziaes, 10～15 parts of Polygonum multiflower knotweeds, 10～15 parts of grass-leaved sweetflags, 10～15 parts of mulberries.

4. a preparation method for the Siberian solomonseal rhizome health-care tea of brain-nourishing intelligence-benefiting as described in claim 1～3 any one, is characterized in that, the preparation process of described Siberian solomonseal rhizome health-care tea comprises following aspect:

A. the preparation of sealwort;

B. by described other raw material pulverizing, immersion, heating, refluxing extraction 2 times;

C. the liquid again other raw materials being extracted is condensed into granule, pulvis or paste;

D. concentrated granule, pulvis or paste are mixed with the sealwort preparing, be prepared into health protection tea.

5. the preparation method of Siberian solomonseal rhizome health-care tea according to claim 4, is characterized in that, in described step a, the sealwort of results is cleaned, and the airing time, at 7-12 hour, parches; Be cut into thin slice, put a pot interior water proof and steam 30-60 minute at 80-100 ℃, then dry; After drying, repeat again to steam once, dry; Repeat again to steam and shine once; Then put into large iron pan and stir-fry, first downwards backward upper, firmly want evenly, when sealwort color starts blackout, start the moulding in 30-45 minute that stir-fries of little fire; When color becomes pitchy, after taking out, naturally dry.

6. the preparation method of Siberian solomonseal rhizome health-care tea according to claim 4, is characterized in that, in described step b, other raw materials is cleaned to impurity elimination, dries, and is ground into particle, soaks 1 hour; Soaked raw material is put to boiling secondary in multi-function extractor; Add up for the first time the water of 10 times of amounts of medicinal material, decoct 1.5～2 hours, get decocting liquid, filter; The water that adds for the second time 7 times of amounts of total amount, decocts 1～1.2 hour, gets twice decocting liquid and mixes, and filters.

7. the preparation method of Siberian solomonseal rhizome health-care tea according to claim 4, is characterized in that, in described step c, the filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator to the concentrate that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Refrigeration liquid is added to 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, convection drying powdered.

8. treat according to claim 4 the preparation method of Siberian solomonseal rhizome health-care tea, it is characterized in that, in described steps d, the powder that the good sealwort of frying is prepared with surplus stock mixes, and ultraviolet disinfection, packs and get final product.

9. a preparation method for basis Siberian solomonseal rhizome health-care tea of brain-nourishing intelligence-benefiting as described in claim 1～3 any one, is characterized in that, when other raw materials of described Siberian solomonseal rhizome health-care tea are made paste, step is:

A, get raw material and put into ethanol and soak, heat is extracted 2 times, becomes paste, is component 1;

B, dregs of a decoction extracting in water 2 times, thickening filtration is paste, is component 2;

C, above-mentioned two kinds of pastes are merged, after ultraviolet radiation for sterilizing and disinfecting, merge packing with the good sealwort of frying.

10. the preparation method of the Siberian solomonseal rhizome health-care tea of brain-nourishing intelligence-benefiting according to claim 9, is characterized in that: in described step a, get in the ethanol that raw material adds 5-10 doubly to measure and soak 1-2 hour, heating is extracted 2 times, each 1-2 hour, removes supernatant, merges extract, 100-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 medicinal extract when ultrafiltrate reduced pressure concentration relative density is 80 ℃, heating is concentrated into paste, stand for standby use, becomes component 1; In described step b, the dregs of a decoction that alcohol extract is crossed are put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1～2 hour, and 100-120 order filters, then through the molecular weight that dams, is the ultrafiltration post ultrafiltration of 5000-10000,1.36 medicinal extract when ultrafiltrate reduced pressure concentration relative density is 80 ℃, heating is concentrated into paste, and stand for standby use, becomes component 2.