CN104888158A

CN104888158A - Folium apocyni veneti oral liquid for enhancing immunity and preparation method thereof

Info

Publication number: CN104888158A
Application number: CN201510394024.4A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Hengbo Instrument Co Ltd
Current assignee: Qingdao Hengbo Instrument Co Ltd
Priority date: 2015-07-07
Filing date: 2015-07-07
Publication date: 2015-09-09

Abstract

The invention provides folium apocyni veneti oral liquid for calming the liver, tranquilizing and enhancing immunity. The folium apocyni veneti oral liquid comprises the following raw materials in part by weight: 10 to 50 parts of folium apocyni veneti, 10 to 20 parts of Eclipta alba, 10 to 20 parts of polygala tenuifolia, 10 to 20 parts of tuber fleeceflower stem, 10 to 20 parts of gardenia, 10 to 20 parts of zizyphus jujube benevolence, 10 to 20 parts of salvia miltiorrhiza, 10 to 20 parts of Ligusticum wallichii, 10 to 20 parts of yanhusuo, 10 to 20 parts of epimedium, 10 to 20 parts of codonopsis pilosula, 10 to 20 parts of poria cocos, 10 to 20 parts of rhizoma zedoariae, 10 to 20 parts of glossy privet fruit, 10 to 20 parts of dogwood, 10 to 20 parts of Concha Margaritiferallsta, 10 to 20 parts of mulberry parasitism, 10 to 20 parts of radix paeoniae alba, 10 to 20 parts of gynostemma, 10 to 20 parts of fructus rosae laevigatae, 10 to 20 parts of astragalus membranaceus, 10 to 20 parts of angelica and 10 to 20 parts of curculigo. The folium apocyni veneti is cold in property, sweet and bitter in taste, and capable of calming the liver, tranquilizing, clearing heat and promoting urination. The folium apocyni veneti oral liquid comprises the main components of rutin, catechin, isoquercetin, glutamic acid, alanine, valine, potassium chloride, and the like, and is capable of generating sperms, supplementing marrow, reinforcing qi, nourishing blood, tonifying brain and tranquilizing.

Description

A kind of Folium Apocyni Veneti oral liquid improving immunity and preparation method thereof

Technical field

The present invention relates to the health product containing deriving from plant composition, particularly a kind of suppressing the hyperactive liver calm the nerves, the Folium Apocyni Veneti oral liquid improving immunity and preparation method thereof.

Background technology

Immunity refers to that body resists external invasion and attack, safeguards the ability of homoiostasis.Various microorganism is filled with: antibacterial, virus, mycoplasma, chlamydia, fungus etc. in air.When body immunity is low, they can become the pathogen of sense mornig shift.Although human body can produce corresponding antibody to different pathogen; to resist subinfection again; but antibody has specificity and time-bounded, such as streptococcus antibody compared with protecting body again not invade by streptococcic in short-term, also can only can not resist the infection of other viruses.The people of hypoimmunity cannot resist the invasion and attack of cold virus at all, and this is only the true cause that Susceptible population frequently catches a cold.

The health of hypoimmunity is easy to infected or cancer stricken.A variety of causes makes immune system normally can not play protective effect, and in the case, very easily cause the infection such as antibacterial, virus, fungus, therefore hypoimmunity the most directly shows is exactly liable to illness.Because of often ill, increased the weight of the consumption of body, thus generally have a delicate constitution, the reduction of malnutrition, lethargy, fatigue and weak, appetite, the performance such as sleep disorder, sick, have an injection and take medicine the normal potluck that just gets married.At every turn sickly all to could to recover for a long time, and usually recurrent exerbation.If things go on like this can cause health and intelligent development bad, also easily bring out major disease.Underlying causes is that hypoimmunity or immunity are unsound.When immune function of human body imbalance, or when immune system is unsound, following point will recurrent exerbation: flu recurrent exerbation, tonsillitis recurrent exerbation, asthma recurrent exerbation, bronchitis recurrent exerbation, pneumonia recurrent exerbation, diarrhoea recurrent exerbation ... so necessarily can't neglect.

Frequent object for appreciation computer game, mobile phone games have become the custom of many people's lives, and somebody can not move at all and plays game in a day.Long-term sitting eye, except binocular blood supply insufficiency, cervical vertebra, lumbar vertebra also can produce strain, less than alleviation, also can must cause damage to liver.The traditional Chinese medical science thinks that the liver being in charge of the eyes: " liver-QI being connected with eyes, liver and then order can distinguish the five colors ".The pathological changes of liver often affects and eyes, the window of this soul.Modern metropolitan cities working clan generally uses computer office, and it is immoderate to add tobacco and wine, and night life is uncontrolled, stays up late, and these have all directly injured irritability.As deficiency of liver-blood, then two dryness and uneasy feeling of the eye, blurring of vision or nyctalopia; Wind-heat of liver channel, visible conjunctival congestion is itched bitterly; Flaming up of liver-fire, visible keratoconjunctivitis; Excessive rising of liver-YANG, the then vertigo; Liver-wind stirring up internally, looks on visible order is oblique.

A wound is had in " five kinds of impairments caused by overstrain " of Huangdi's Internal Classics: " impairment of blood by looking for a long time ".Here blood, what refer to is exactly liver blood.Eyes and liver contact closely.Blood stored in the liver, namely liver has stored blood and regulates the function of blood volume, and liver opening at eye.The provisions that eyes are subject to blood just can look thing, and excessively uses eye, can make liver-blood deficiency, make binocular can not get the supply of nutrition, thus go out to lose face dry and astringent, see thing is fuzzy, nyctalopia etc.In addition, long-term sitting eye is played games, and except binocular blood supply insufficiency, cervical vertebra, lumbar vertebra also can produce strain, less than alleviation, also can must cause damage to liver.In this case, occur that eyes are tired, visual deterioration, even shallow complexion, dizzy symptom, just not strange yet.Watching for a long time and radiation, the eye health for computer gang has buried hidden danger.

Liver controlling conveyance and dispersion, the general reference comprehensive physiological functions such as irritability has dredging, bar reaches, liter is sent out, freely let out.Ancients rush with wood gas the catharsis function resembling analogy liver with bar soothing the liver, therefore are belonged to wood in the five elements, therefore " the secret allusion quotation opinion of Plain Questions LINGLAN " is said: " liver person; organ of general considers and here ", " Plain Questions six saves state of internal organs opinion " is said: " liver person; source of endurance, the residence of soul also ".The function of liver controlling conveyance and dispersion is mainly manifested in and regulates spiritual feelings will, and facilitating digestion absorbs, and maintains operation three aspect of QI and blood, body fluid.

Folium Apocyni Veneti, another name: bluish dogbane, Herba Euphorbiae Helioscopiae fiber crops, wild Folium Camelliae sinensis, Arisaema balansae Engl. grass, wild flax; Latin literary fame: dogbane leaf. Angiospermae, its feeble QI, lightly seasoned sweet, bitter, cold.Return Liver Channel.Function with cure mainly: suppressing the hyperactive liver is calmed the nerves, clearing away heat and promoting diuresis.For dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria; Hypertension, neurasthenia, nephritis edema.Folium Apocyni Veneti is cold in nature. and sweet in the mouth, hardship, suppressing the hyperactive liver is calmed the nerves, clearing away heat and promoting diuresis.Main component rutin, catechu rope, isoquercitrin rope, glutamic acid, alanine, valine, potassium chloride etc., wherein antihypertensive compositions is Quercetin, total flavones, has blood pressure lowering, strengthens capillary resistance, reduces capillary fragility, falls that blood refers to, coronary artery dilator increases coronary artery blood flow effect.And pass through vascular smooth muscle cell voltage dependent Ca 2+ channels and the effect of receptor-operated Ca2+ passage double inhibition, reduce Intracellular signaling level, this may be one of vasodilator Hypotensive Mechanism.

Pharmacological action: Folium Apocyni Veneti decoct has hypotensive effect; Root of Apocynum venetum L. decoct has cardiotonic; Folium Apocyni Veneti extractum has calmness, anticonvulsant action, and has stronger diuresis, reduction blood fat, immunity moderation, defying age and suppress the effects such as influenza virus.Untoward reaction: Folium Apocyni Veneti preparation is for oral administration can occur nausea,vomiting,diarrhea, epigastric discomfort, also can occur bradycardia and premature beat.Dizziness can be there is when inhaling Herba Apocyni veneti cigarette, choke cough, feel sick, insomnia etc.

Modern selects some health foods or functional food to be in order to building body.The function of health product mainly improves blood circulation of human body, improving water flood, enriching yin and nourishing kidney, to reach reducing pressure and sugar blood fat-reducing blood pressure-decreasing; Improve the effect of body immunity.The various health product sold on the market now, dragons and fishes jumbled together for medicine, and the amusement of great majority just false propaganda, what have does not only have health-care components, also causes the huge injury of the person.Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.Brain overwork, excess eye-using can cause autonomic nervous dysfunction, thus causes cerebrovascular shrink function abnormal, blood supply insufficiency, occurs that dizziness headache is uncomfortable in chest, insomnia forgetfulness, eyes do the symptoms such as wet.To touch upon the main blood of liver according to blood stasis, adjust the theory of blood, adopt blood circulation promoting and blood stasis dispelling, soothing the liver tune blood (namely nursing one's health cerebrovascular wall systolic and diastolic function) and reach therapeutic purposes.Selected Chinese medicinal material of the present invention is all can use for a long time and not injure human body, and energy obviously enriching yin and nourishing kidney, clearing away liver-fire, the nutrition of recovery brain, improve the good timber of immunity and improving water flood.

Summary of the invention

Technical problem to be solved by this invention is, the various health product sold on the market now, dragons and fishes jumbled together for medicine, and the amusement of great majority just false propaganda, what have does not only have health-care components, also causes the huge injury of the person.Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.The present invention has the kidney invigorating and essence nourishing, nourishing liver for improving eyesight, reduce phlegm out steal, brain-nourishing intelligence-benefiting, invigorating blood circulation addiction, calm the nerves with all worries set aside, significantly improve body immunity effect.Folium Apocyni Veneti is cold in nature. and sweet in the mouth, hardship, suppressing the hyperactive liver is calmed the nerves, clearing away heat and promoting diuresis.Main component rutin, catechu rope, isoquercitrin rope, glutamic acid, alanine, valine, potassium chloride etc., wherein antihypertensive compositions is Quercetin, total flavones, there is blood pressure lowering, strengthen capillary resistance, reduce capillary fragility, fall that blood refers to, coronary artery dilator, increase coronary artery blood flow effect.Spermatogenesis of the present invention mends marrow, and benefiting QI and nourishing blood, strong brain is calmed the nerves.

For solving above-mentioned technical barrier, the invention provides a kind of suppressing the hyperactive liver to calm the nerves, improve the Folium Apocyni Veneti oral liquid of immunity, described in it, Folium Apocyni Veneti oral liquid comprises the raw material of following parts by weight: Folium Apocyni Veneti 10 ~ 50 parts, Herba Ecliptae 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Semen Ziziphi Spinosae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, 10 ~ 20 parts, Poria, Rhizoma Curcumae 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Concha Margaritifera 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Fructus Rosae Laevigatae 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Rhizoma Curculiginis 10 ~ 20 parts.

Described suppressing the hyperactive liver is calmed the nerves, improve the Folium Apocyni Veneti oral liquid of immunity, in Folium Apocyni Veneti oral liquid described in it, the parts by weight of various raw material can be: Folium Apocyni Veneti 10 ~ 30 parts, Herba Ecliptae 10 ~ 15 parts, Radix Polygalae 10 ~ 15 parts, Caulis Polygoni Multiflori 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, Semen Ziziphi Spinosae 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Rhizoma Corydalis 10 ~ 15 parts, Herba Epimedii 10 ~ 15 parts, Radix Codonopsis 10 ~ 15 parts, 10 ~ 20 parts, Poria, Rhizoma Curcumae 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Concha Margaritifera 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Fructus Rosae Laevigatae 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Rhizoma Curculiginis 10 ~ 20 parts.

Described suppressing the hyperactive liver is calmed the nerves, improve the Folium Apocyni Veneti oral liquid of immunity, in Folium Apocyni Veneti oral liquid described in it, the parts by weight of various raw material can also be: Folium Apocyni Veneti 10 ~ 50 parts, Herba Ecliptae 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Semen Ziziphi Spinosae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, 10 ~ 15 parts, Poria, Rhizoma Curcumae 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, Concha Margaritifera 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, the Radix Paeoniae Alba 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 10 ~ 15 parts, Fructus Rosae Laevigatae 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Rhizoma Curculiginis 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of suppressing the hyperactive liver to calm the nerves, improves the preparation method of the Folium Apocyni Veneti oral liquid of immunity, and described in it, the preparation process of Folium Apocyni Veneti oral liquid comprises following aspect:

A. the preparation of Folium Apocyni Veneti, adds ethanol extraction 2 times, becomes component 1;

B. by heating extraction in all the other raw material soaking ethanol described 2 times, the medicinal residues extracted extracting in water 2 times again, merges extracted twice liquid and becomes component 2;

C. merge component 1 component 2, add dextrin after concentrated and be in harmonious proportion, after disinfection, be prepared into health oral liquor.

In described step a, Folium Apocyni Veneti of can gathering in annual summer, plucked to spread out and shone or dry, sieve discarding stalk, raises clean impurity; Add in the ethanol accounting for its quality 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, then puts into concentrating under reduced pressure tank, decompression recycling ethanol, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06 extractum, become component 1.

In described step b, all the other raw medicinal materials can be mixed, put into the ethanol accounting for its quality 10 times amount and soak more than 24 hours, heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution be merged and leaves standstill; The medicinal residues of the medical material crossed by above-mentioned ethanol extraction again add the water heating and refluxing extraction 2 times accounting for its quality 10 times amount, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill; Above-mentioned two kinds of extracting solution are merged, as component 2.

In described step c, the component 1 that above-mentioned steps can be obtained mixes with component 2, inserts in economic benefits and social benefits vacuum concentrator, and when being concentrated into 80 DEG C, relative density is the extractum of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, extractum is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.2g crude drug amount; Unguentum after concentrated adds Mel and is modulated into oral liquid.

For solving the problems of the technologies described above, the present invention reoffers a kind of suppressing the hyperactive liver and to calm the nerves, improve the preparation method of Folium Apocyni Veneti oral liquid of immunity, and its preparation process can also be:

A. the preparation of Folium Apocyni Veneti;

B. the Folium Apocyni Veneti prepared is mixed with other crude drug, with ethanol extraction;

C. will extract raw material concentration of liquid medicine, after add appropriate propolis be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.

In described step a, can to gather Folium Apocyni Veneti in annual early June to early October, then spread out and shine or dry, sieve discarding stalk, raises clean impurity; Dry in the sun is good, for subsequent use, also can pluck in rear iron pan the 10-15 minute that stir-fries, knead.

In described step b, can get all crude drug steeps in ethanol, add in the ethanol accounting for its quality 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use; In described step c, extractum above-mentioned steps obtained is inserted in economic benefits and social benefits vacuum concentrator, and when being concentrated into 80 DEG C, relative density is the extractum of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, extractum is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.2g crude drug amount; Unguentum after concentrated adds Mel or dextrin is modulated into oral liquid, canned.

The technique effect that the present invention is useful is, the present invention does not have the unpleasant taste of Chinese medicine being difficult to swallow, and makes people be easy to accept, can significantly improve immunity, can improve sub-health population easy catching a cold preferably, eyes are sour and astringent, sleep quality is not high, insufficiency of the spleen weak; Lack of appetite xerostomia; Quench one's thirst; Deficiency of the kidney soreness of the waist and knees; Impotence and seminal emission; Tinnitus order is dark; Early whitening of beard and hair; Body void is won thin; The symptom of wind favus disease, can reach the effect improving immunity preferably.Folium Apocyni Veneti is cold in nature. and sweet in the mouth, hardship, suppressing the hyperactive liver is calmed the nerves, clearing away heat and promoting diuresis.Main component rutin, catechu rope, isoquercitrin rope, glutamic acid, alanine, valine, potassium chloride etc., wherein antihypertensive compositions is Quercetin, total flavones, has blood pressure lowering, strengthens capillary resistance, reduces capillary fragility, falls that blood refers to, coronary artery dilator increases coronary artery blood flow effect.The micro-bitter glycol of the present invention; Add some blood circulation promoting and blood stasis dispelling, mouthfeel is light, makes people be easy to accept, and can reach suppressing the hyperactive liver preferably and to calm the nerves, improve effect of immunity.

Detailed description of the invention

Human immunity is the defensive enginery of human body pathogenic microorganism to external world etc., or perhaps system of defense, and under normal circumstances, it can ensure human body not by the infringement of extraneous pathogenic microorganism.The body immunity of usual theory just refers to that the immune system of human body resists the ability of the infringements such as exotic disease pathogenic microorganism.In the normal situation of body immunity, human body self can resist the infringement of considerable pathogenic bacteria, avoids causing damage to human body.Immunity plays an important role in human life mechanism, and the nutrition of human body, fatigue, mood, environment, disease, medication, radiation etc. cause the immunity degradation of self.More and more research shows, the adjustment of Chinese medicine to body immunity more and more plays a significant role.

Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, people more than half is made to be in sub-health state, show as: dizzy, nervous, weak, inappetence, hypomnesis, insomnia, indifferent to etc. to thing, in addition, long-term diet is unreasonable, that is: smart grain replaces coarse grain completely, a large amount of three-hypers (high heat, high protein, higher fatty acid), more than three, (antiseptic is many, flavour enhancer is many, hormone is many) pesticide residual in the absorption of food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and quantity of motion less than normal, go down to make three-hypers disease (hypertension for a long time like this, hyperglycemia, hyperlipidemia), cardiovascular and cerebrovascular disease, cancers etc. so-called " modern civilization diseases " rise rapidly, and constantly rejuvenation, the serious health and lives jeopardizing the mankind.A variety of causes makes immune system normally can not play protective effect, and in the case, very easily cause the infection such as antibacterial, virus, fungus, therefore hypoimmunity the most directly shows is exactly liable to illness.

Liver opening at eye, it is foster that objective vision function mainly relies on moistening of the cloudy blood of liver; The passages through which vital energy circulates first line of a couplet order system again of liver.Therefore, whether normal the function of liver is usually reflects on order.Such as: blurred vision, nyctalopia can appear in deficiency of liver-blood; Deficiency of the yin of the liver, then two dryness and uneasy feeling of the eye, visual deterioration; Flaming up of liver-fire, then conjunctival congestion and swelling pain.The traditional Chinese medical science is emphasized, people wants frequent dispersing liver-energy, liver heat removing poison, falls liver-fire, nourishing the liver blood, and dispersing liver-energy can make the catharsis of whole body mechanism of qi unobstructed, in body on stifled then face without pox; Liver heat removing poison can dissolve elimination internal pollution, and in body, nontoxic then face is without dead color; Fall liver-fire and can make equilibrium between yin and yang in body, in body, not burnt then skin moisturizing is not dry; Nourishing the liver blood can nourish whole body internal organs, and liver blood is full, and then body surface gloss is flexible.Repair damaged liver, make whole body mechanism of qi free flow of qi, the smooth and easy operation of whole body QI and blood, to reach soothing the liver skin care object.Toxigenic source is liver.When liver can not complete removing toxic substances work well, toxin is just stretched in vivo.First soothing the liver skin care starts with from liver health, allows healthy liver complete every removing toxic substances work, thoroughly cuts off toxin source, make appearance beautiful lastingly.

The traditional Chinese medical science thinks that the liver being in charge of the eyes: " liver-QI being connected with eyes, liver and then order can distinguish the five colors ".The pathological changes of liver often affects and eyes, the window of this soul.Modern metropolitan cities working clan generally uses computer office, and it is immoderate to add tobacco and wine, and night life is uncontrolled, stays up late, and these have all directly injured irritability.As deficiency of liver-blood, then two dryness and uneasy feeling of the eye, blurring of vision or nyctalopia; Wind-heat of liver channel, visible conjunctival congestion is itched bitterly; Flaming up of liver-fire, visible keratoconjunctivitis; Excessive rising of liver-YANG, the then vertigo; Liver-wind stirring up internally, looks on visible order is oblique.

Folium Apocyni Veneti is cold in nature. and sweet in the mouth, hardship, suppressing the hyperactive liver is calmed the nerves, clearing away heat and promoting diuresis.Main component rutin, catechu rope, isoquercitrin rope, glutamic acid, alanine, valine, potassium chloride etc., wherein antihypertensive compositions is Quercetin, total flavones, has blood pressure lowering, strengthens capillary resistance, reduces capillary fragility, falls that blood refers to, coronary artery dilator increases coronary artery blood flow effect.And pass through vascular smooth muscle cell voltage dependent Ca 2+ channels and the effect of receptor-operated Ca2+ passage double inhibition, reduce Intracellular signaling level, this may be one of vasodilator Hypotensive Mechanism.

The Radix Paeoniae Alba is cool in nature, and bitter in the mouth acid, is slightly cold, has easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving.Yin fluid astringing receives the effects such as antiperspirant, is applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction suddenly, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.Paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.The condition subject such as the blood deficiency deficiency of YIN, the breast abdomen pain over the hypochondriac region, pain in the hepatic region, cholecystitis, gallstone pain, dysentery stomachache, women's menalgia, spontaneous perspiration easy antiperspirant night sweat, sural spasm, spasm of the limbs pain, uneasy lower limb syndrome are suitable edible.

Rhizoma Chuanxiong enters liver, spleen, three burnt three warps.Function cures mainly activating QI to alleviate the depression, and method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." detailed outline " carries: " dampness, antidiarrheal dysentery, activating QI to alleviate the depression." ligustrazine removes vascular smooth muscle (aortic article) spasm (epinephrine, potassium chloride cause).Can also coronary vasodilator be expanded, increase coronary flow.The myocardial ischemia-anoxemia that antagonism pituitrin causes.Alleviate the myocardial infarction lesion degree that ligation arteria coronaria causes.

Fructus Ligustri Lucidi, sweet-bitter flavor, cool in nature, return Liver and kidney warp, there is nourishing the liver and kidney, merit that tonifying YIN nourishes blood.Modern medicine study proves, Fructus Ligustri Lucidi includes ursolic acid, mannitol, glucose, fatty wet goods, has heart tonifying, diuresis and hepatoprotective effect, the leukopenia quantity caused because of chemotherapy can be made to raise, and have inhibitory action to staphylococcus aureus, escherichia coli.The acid of oleanolic acid Fructus Ligustri Lucidi, nuezhenoside, ursolic acid, stearic acid, oleic acid, mannitol, betulin, phospholipid and saccharide is contained as Fructus Ligustri Lucidi polysaccharide, arabinose, glucose etc. in Fructus Ligustri Lucidi, also containing 15 seed amino acids, 11 kinds of trace element and volatilization wet goods.Research thinks that Fructus Ligustri Lucidi has blood sugar lowering and blood fat reducing and has study of anti-atherogenic effect, and antibacterial, antivirus action in addition, Fructus Ligustri Lucidi decoct all has inhibitory action to staphylococcus aureus, shigella flexneri, Bacillus typhi, bacillus pyocyaneus and escherichia coli.

Radix Polygalae (formal name used at school: Polygala tenuifolia Willd.) is Polygalaceae, rogation flower.Produce northeast, North China, northwest and Central China and Sichuan.Warm in nature, bitter in the mouth, pungent, the function of have Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Clinical practice crude Radix Polygalae, Radix Polygalae (processed) and honey polygala root three kinds.

Record in a Semen Ziziphi Spinosae China medicine book Shennong's Herbal the earliest: " invigorating middle warmer the liver benefiting, hard muscles and bones help cloudy gas, and all the merit of Semen Ziziphi Spinosae also." record in Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica, " insomnia due to insufficiency of the gallbladder-qi in ripe treatment, the disease of excessive thirst sweating due to debility for Semen Ziziphi Spinosae; Life is treated gallbladder-heat and is slept well, and all foot faints cloudy few positive medicine also.Nourishing the liver, mind calming, calms the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.1. " herbal classic ": main trusted subordinate's cold and heat, pathogens agglomerating gas gathers, painful limbs, arthralgia chiefly caused by damp pathogen.2. " not Lu ": main vexatious insomnia, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, and hard muscles and bones helps cloudy gas, makes us fertile strong.3. " property of medicine opinion ": main muscles and bones wind, fry end and take it as soup.4. supplement to the Herbal: many lifes of sleeping make, and must not sleep and fry.5. Wang Haogu: control milk-livered sleeplessness, trembles with fear also, fries clothes; Control somnolence due to gallbladder-excess, heat also, use by life.6. " book on Chinese herbal medicine converges and says ": astringing QI is calmed the nerves, and flourish muscle supports marrow, stomach function regulating activating the spleen.7. " book on Chinese herbal medicine is new again ": suppressing the hyperactive liver is regulated the flow of vital energy, nourishing lung-YIN, warming middle-JIAO dampness removing, astringing QI hidroschesis, and beneficial will is breathed out surely, hearing-improing and eyesight improving.

Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang ex Z.Y.Su et C.Y.Wu), Papaveraceae, Corydalis perennial herb, another name: Rhizoma Corydalis, corydalis tuber, rhizoma corydalis, Rhizoma Corydalis.Chinese tradition medical material.Mainly originate in Zhejiang and Jiangsu.Its tuber (Rhizoma Corydalis Decumbentis), containing the multiple alkaloid such as corydaline, protopine, through making powder or fluid-acet-extract etc., cures mainly all pains of trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.There are analgesia, calmness, syngignoscism.

Herba Epimedii is Chinese conventional Chinese medicine, has very high medical value, perennial herb, and YIN nourishing is taken a tonic or nourishing food to build up one's health, and tonifying YANG is kept fit.Bitter and puckery flavor, suitable insomniac uses.Herb hyoscine.Cure mainly impotence and premature ejaculation, pain in the low back and legs, numb limbs and tense tendons, hemiplegia, neurasthenia, forgetful, tinnitus, dizzy disease such as grade.Excessive sheep flower bud is Chinese conventional Chinese medicine.

Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Nature and flavor are sweet, light flat.There are the functions such as eliminating dampness by diuresis, spleen invigorating, mind calming.For phlegm retention, edema, dysuria, have loose bowels, cardiopalmus, dizzy.Cortex Sclerotii Poriae, inducing diuresis to remove edema, the diseases such as the edema that wets for water, for palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria." not Lu ": treat dizziness due to wind pathogen, wind be empty, five kinds of over strain, xerostomia.Spasmolytic is throbbed with fear, and is enraged more, forgetful.Happy Fructus Alpiniae Oxyphyllae, supports spirit.

Concha Margaritifera suppressing the hyperactive liver and subsiding YANG; To calm the nerves arresting convulsion; Liver heat removing and eyesight improving is investigated.Function cures mainly suppressing the hyperactive liver, YANG hyperactivity suppressing, arresting convulsion, hemostasis.Control dizziness, tinnitus, cardiopalmus, insomnia, demented, infantile convulsion, spits blood, epistaxis, metrorrhagia." Chinese medicine voluminous dictionary ": liver nourishing is cloudy, clearing away liver-fire.Control demented infantile convulsion, dizziness, tinnitus, heart beating, pleuroperitoneum is swollen, women's heat in blood, metrorrhagia, and frightened the jerking of children's sends out convulsion." decoction pieces is newly joined ": suppressing the hyperactive liver and subsiding YANG, soul of calming the nerves, arresting convulsion epilepsy, the fullness-oppression in the epigastrium caused by heat that disappears, mist." Jilin Chinese herbal medicine ": hemostasis.Control haematemesis, epistaxis, metrorrhagia.

Fructus Rosae Laevigatae, formal name used at school: Rosa laevigata is Rosaceae gul; Fruit medicine, has diuresis, kidney tonifying functions; Leaf has removing toxic substances and promoting subsidence of swelling effect; Root is medicinal, can promoting blood circulation to remove blood stasis, convergence of drawing out pus by applying a plaster to the affected part, dispel the wind that it is wet to drive.Fructus Rosae Laevigatae fruit has the function of tonifying the kidney to consolidate the essence and antidiarrheal, cures mainly the diseases such as hypertension, neurasthenia, chronic cough.Fructus Rosae Laevigatae cotyledon energy removing toxic substances and promoting subsidence of swelling, external can control the diseases such as stasis of blood furuncle, burn and scald, traumatic hemorrhage.Radix Fructus Rosae Laevigatae has the function such as promoting blood circulation to remove blood stasis, expelling wind and removing dampness.

Caulis Polygoni Multiflori is the rattan of Radix Polygoni Multiflori, and gain the name because can automatically mutually join at night, medicinal Radix Polygoni Multiflori is then the tuber of this kind of plant.The traditional Chinese medical science is thought, Caulis Polygoni Multiflori is put down nontoxic, sweet and slightly bitter taste, enters the heart, Liver Channel, has effect of tranquilizing and blood nourishing, dispelling wind and removing obstruction in the collateral, cures mainly the diseases such as deficiency of YIN insufficiency of blood, restlessness of asrhenia type and insomnia, rheumatic arthralgia, itchy skin eruption.The decoction dosage of Caulis Polygoni Multiflori is generally 10 ~ 30 grams, also can decoction being used as a lotion or smash deposited external.Main clinical practice brief introduction is as follows.Insomnia Caulis Polygoni Multiflori has nourishing blood to tranquillize the mind effect, for the insomnia caused by deficiency of YIN insufficiency of blood, and the medicine fit applications such as normal and Cortex Albiziae, Semen Ziziphi Spinosae, Semen Platycladi, Radix Polygalae.

Fructus Gardeniae is Chinese medicine, belongs to the 1st batch of medicine-food two-purpose resource that Ministry of Public Health is promulgated, has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence, is usually used in the diseases such as treatment icterohepatitis, bruise, hypertension, diabetes at tcm clinical practice.Cure mainly calentura vexed; Liver-fire conjunctival congestion; Headache; Jaundice due to damp-heat; Stranguria; Dysentery hematuria; Aphtha of the mouth and tongue; Sore swollen toxin; Sprain and swell and ache.This product has very large curative effect to conjunctival congestion and swelling pain.These product rush down clearly three burnt pathogenic heats, can treating the liver gallbladder burning hot on the conjunctival congestion and swelling pain of attacking, often join Radix Et Rhizoma Rhei use, as Fructus Gardeniae soup " Shengji Zonglu ".

Radix Codonopsis is traditional tonic that China commonly uses, and the Radix Codonopsis that ancient times produce with area, Shangdang, Shanxi is top grade, has invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.Modern study, Radix Codonopsis, containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, Saponin and Alkaloid, has enhancing immunity, blood vessel dilating, blood pressure lowering, improves microcirculation, strengthens the effects such as hemopoietic function.In addition castering action is had to the leukopenia that chemotherapy radiotherapy causes.Radix Codonopsis has invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst." Bencao Congxin " is recorded: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.Middle feeble QI is weak, mends in order to adjust, very smooth and proper.”

Rhizoma Curcumae is pungent, bitter, temperature.Return liver, spleen channel.Cure mainly that " lump in the abdomen, gathers, and dyspepsia does not disappear for coagulation of QI-blood, trusted subordinate's distending pain, and women's blood stasis amenorrhea, traumatic injury is had a pain." there are promoting QI circulation for relieving depression, removing blood stasis with potent drugs, the function of pain relieving.Curcumenol extract and volatile oil raise the mice alanine aminotransferase (ALT) that carbon tetrachloride (CCI4) thioacetamide (TAA) causes obvious reducing effect, sulfobromophthalein sodium (BSP) retention amount is reduced, and corresponding liver tissue lesions alleviates.

Fructus Corni sour in the mouth, adstringency, tepor.Return liver, kidney channel.Liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed, and interior-heat is quenched one's thirst, for astringent drug, it contains the not multiple active ingredient such as iridoid glycosides and Saponin, ursolic acid, tartaric acid, gallic acid, malic acid, Fructus Corni tannin 1,2,3 such as sieve glycoside, Cornuside, sweroside, loganin of cornin, not sieve glycoside, 7-O-methyl.There are obvious diuresis, blood fat reducing, antibacterial effect leukocytic with elevating blood, have obvious curative effects to the disease such as vertigo and tinnitus, the soreness of waist caused by treatment deficiency of both the liver and kidney and the disease such as seminal emission, frequent micturition caused by deficiency of kidney yin.Again because it has the menorrhagia that astringing to arrest bleeding effect is usually used in caused by human female void, the diseases such as bleeding not during menses, good therapeutical effect is all had to the commonly encountered diseases of andrology, gynecological, in a large number for the production of tonification medicine, therefore be listed in one of traditional Chinese medicines 40 kinds of large kinds, there is market widely at Chinese medicine circle.

Herba Taxilli is bitter; Sweet; Property is put down.There is wind-damp dispelling, liver and kidney tonifying, bone and muscle strengthening, antiabortive effect.Enter the heart, kidney two warp.Function cures mainly: invigorating the liver and kidney; Bone and muscle strengthening; Wind-damp dispelling; Antiabortive.Main soreness of waist and knee joint; Muscles and bones flaccidity is weak; Limbs are hemiplegia; Rheumatic arthralgia; Head is wrong dizzy; Frequent fetal movement, metrostaxis.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; Hypertension.

Herb Gynostemmae Pentaphylli has adaptive capacity widely, has significant inhibitory action to multiple cancerous cell; In addition, Herb Gynostemmae Pentaphylli also has blood fat reducing, blood pressure lowering, blood sugar lowering, calmness, hypnosis, antitonic, antiulcer, resisting fatigue, prolongation cell survival and appetite stimulator, build up resistance, unobstructed stool, antiasthmatic-antitussive, the hemorrhoid that disappear, fat-reducing, treatment deficient syndrome, suppression cholelithiasis are formed, prevent and treat glucocorticoid side effect, anti-ageing multiple efficacies of waiting for a long time.Except the effect with Radix Ginseng, also there is the multiple effect that Radix Ginseng does not possess, and there is no reaction and any other toxic and side effects of Radix Ginseng excessive use.

The Radix Astragali, can invigorating QI to consolidate the body surface resistance based on tonify deficiency, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Cave in for insufficiency of vital energy and blood, skin infection, difficulty in discharging of pus or burst for a long time and do not hold back person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and the immunologic function of energy enhancing body, therefore can also be used for the generation preventing some infectious disease." book on Chinese herbal medicine meets former " carries: " all void of Radix Astragali energy tonifying five ZANG-organs, controls stringy pulse spontaneous perspiration, rush down YIN-fire, remove lung-heat, lossless, sends out, and has antiperspirant then to stop." be the good medicine promoting resistance and defence disease.

Radix Angelicae Sinensis: its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Rhizoma Curculiginis has the effect that reinforcing the kidney and supporting YANG, benefiting essence-blood, bone and muscle strengthening and promoting the circulation of blood are subsided a swelling, and is mainly used in the diseases such as insufficiency of kidney-YANG, impotence and seminal emission, chronic consumptive disease internal injury and bones and muscles pain.Kidney-replenishing, bone and muscle strengthening, cold expelling wets.Control sexual impotence cold sperm, urinary incontinence, metrorrhagia, trusted subordinate's cold type of pain, cold arthralgia of loins and legs, carbuncle, scrofula, yang deficiency cold diarrhea.Sexual impotence essence is cold, the diseases such as waist knee joint is air-cooled, muscles and bones flaccidity syndrome and arthralgia syndrome.Rhizoma Curculiginis ball is had, energy strengthening bone and muscle, benefit spirit, improving eyesight, black beard and hair in ancient prescription." Haiyao Bencao, Oversea Materia Medica ": main air, mend warm waist foot, clear settling five organs, bone and muscle strengthening, helps digestion.Declare and mend again, main husband's seven kinds of impairments, improve visual and auditory acuity, beneficial biceps, filling out bone marrow, Yiyang." Japan hanako materia medica ": control all pathogenic wind, mends five kinds of strain and seven kinds of impairment, the appetizing therapeutic method to keep the adverse QI flowing downwards.

Specific embodiment 1:

To gather in annual summer Folium Apocyni Veneti in annual early June to late October, plucked to spread out and shone or dry, sieve discarding stalk, raises clean impurity, adds ethanol or water extraction, as component 1.

Again by all the other raw material Herba Ecliptaes, Radix Polygalae, Caulis Polygoni Multiflori, Fructus Gardeniae, Semen Ziziphi Spinosae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Corydalis, Herba Epimedii, Radix Codonopsis, Poria, Rhizoma Curcumae, Fructus Ligustri Lucidi, Fructus Corni, Concha Margaritifera, Herba Taxilli, the Radix Paeoniae Alba, Herb Gynostemmae Pentaphylli, Fructus Rosae Laevigatae, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Curculiginis, adds ethanol or water extraction, as component 2.

Mix concentrated by component 1 component 2 of extraction, add Mel or propolis, dextrin is in harmonious proportion, ultraviolet radiation for sterilizing and disinfecting is bottled.

Specific embodiment 2:

To gather in annual summer Folium Apocyni Veneti in annual early June to late October, plucked to spread out and shone or dry, sieve discarding stalk, raises clean impurity, can put into iron pan slow fire and to stir-fry 10-15 minute, about 5000g.Then add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, and when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, the extractum of 1.36 is as component 1; Get other raw material Herba Ecliptae 1500g, Radix Polygalae 1500g, Caulis Polygoni Multiflori 1500g, Fructus Gardeniae 1500g again, Semen Ziziphi Spinosae 1500g, Radix Salviae Miltiorrhizae 1500g, Rhizoma Chuanxiong 1500g, Rhizoma Corydalis 1500g, Herba Epimedii 1500g, Radix Codonopsis 1500g, Poria 1500g, Rhizoma Curcumae 1500g, Fructus Ligustri Lucidi 1500g, Fructus Corni 1500g, Concha Margaritifera 1500g, Herba Taxilli 1500g, Radix Paeoniae Alba 1500g, Herb Gynostemmae Pentaphylli 1500g, Fructus Rosae Laevigatae 1500g, Radix Astragali 1500g, Radix Angelicae Sinensis 1500g, Rhizoma Curculiginis 1500g.Add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, stand for standby use, as component 2; Again by also 2-in-1 for component 1 component, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.2g crude drug amount, then adds dextrin and is in harmonious proportion, ultraviolet disinfection, bottling.

Specific embodiment 3:

To gather in annual summer Folium Apocyni Veneti in annual early June to late October, plucked to spread out and shone or dry, sieve discarding stalk, raises clean impurity, about 4000g.

Get other raw material Herba Ecliptae 1200g, Radix Polygalae 1100g, Caulis Polygoni Multiflori 1200g, Fructus Gardeniae 1200g again, Semen Ziziphi Spinosae 1200g, Radix Salviae Miltiorrhizae 1200g, Rhizoma Chuanxiong 1100g, Rhizoma Corydalis 1100g, Herba Epimedii 1200g, Radix Codonopsis 1100g, Poria 1100g, Rhizoma Curcumae 1100g, Fructus Ligustri Lucidi 1200g, Fructus Corni 1100g, Concha Margaritifera 1200g, Herba Taxilli 1200g, Radix Paeoniae Alba 1200g, Herb Gynostemmae Pentaphylli 1200g, Fructus Rosae Laevigatae 1100g, Radix Astragali 1100g, Radix Angelicae Sinensis 1100g, Rhizoma Curculiginis 1100g.Get crude drug to clean and dry, in 70 DEG C of baking ovens, dry 1-3h, take out and be placed in cooling in drying baker, pulverized 80-100 mesh sieve with pulverizer.The Folium Apocyni Veneti be mixed with, one bubbles in ethanol after 1-2 days, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-110 order filters, be the ultrafiltration post ultrafiltration of 6000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.2g crude drug amount, then adds dextrin and is in harmonious proportion, ultraviolet disinfection, bottling.

Specific embodiment 4:

To gather in annual summer Folium Apocyni Veneti in annual early June to late October, pluck to spread out and shone or dry, sieve discarding stalk, raise clean impurity, about 4200g, get other raw material Herba Ecliptae 1200g again, Radix Polygalae 1100g, Caulis Polygoni Multiflori 1200g, Fructus Gardeniae 1200g, Semen Ziziphi Spinosae 1200g, Radix Salviae Miltiorrhizae 1200g, Rhizoma Chuanxiong 1300g, Rhizoma Corydalis 1300g, Herba Epimedii 1200g, Radix Codonopsis 1100g, Poria 1100g, Rhizoma Curcumae 1300g, Fructus Ligustri Lucidi 1200g, Fructus Corni 1100g, Concha Margaritifera 1200g, Herba Taxilli 1200g, Radix Paeoniae Alba 1200g, Herb Gynostemmae Pentaphylli 1200g, Fructus Rosae Laevigatae 1300g, Radix Astragali 1300g, Radix Angelicae Sinensis 1300g, Rhizoma Curculiginis 1200g, be mixed and put into acid and alkali-resistance infusion kettle, at room temperature, 3 ~ 7 days are flooded together with more than 70 degree ethanol, then heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, filter, filtrate is got after separation, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, and merge lixiviating solution, being condensed into pasty state becomes component 2, by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the extractum of 1.60, and the unguentum after concentrated adds propolis or dextrin and is in harmonious proportion bottling.

Pharmacological toxicity is tested

One, skin irritation test

1, experimental technique

Depilatory is evenly coated by guinea pig back spinal column both sides, makes unhairing scope about 20 square centimeters.Clean depilatory returns cage to observe 24 hours, often organizes Cavia porcellus and is coated with the present invention 4,8 and 12g respectively, and respectively containing crude drug 92mg, 184mg and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous one week, after experiment terminates, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin do pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity are movable, histopathologic examination, the administration group heart, liver, kidney and depilation skin with contrast word more also no significant difference.

Result is pointed out, and the present invention, without local irritant effect, also has no general toxicity performance.Show invention formulation use safety.

Two, animal acute toxicity test research:

The present invention, through trial test, can not measure LD 50, therefore measures maximum dosage-feeding.Adopt rectal delivery, the maximum dosage-feeding on the one recording mice is 62.7g/kg (in medicated powder), be about 1567.5 times (people is in 60kg) intending clinical people's consumption, the maximum dosage-feeding 62.7g/kg (in medicated powder) on the one of rat, is about 1567.5 times that intend clinical people's consumption.The equal Continuous Observation of laboratory animal one week, its outward appearance sign, the mental status, diet, drinking-water, feces etc. are showed no obvious abnormalities.At the end of experiment, all healthy survival of animal, body weight increases.

Three, long-term toxicity test for animals research:

This test establishes medicine of the present invention high, in, low dose group and Matrix controls group, blank group, rectal delivery is adopted to give rat, dosage is respectively 3.2, 2.4 and 1.6g/kg (in medicated powder), be equivalent to intend 80 of clinical patient consumption [0.04g (medicated powder)/kg], 60 and 40 times, successive administration 2 months, in administration process, the body weight of each administration group and matrix group rat, dietary amount, outward appearance sign, behavioral activity, the mental status, hair color, feces character compares with blank group, no significant difference (P > 0.05), the weight of animals increasing value and Main Organ Coefficients and blank group comparing difference are not significantly (P > 0.05), hematology and the indivedual index of blood parameters check result administration group and blank group comparing difference are significantly (P < 0.05), but convalescent period terminates rear discrepant hematology and blood parameters has recovered normal all, other indexs and blank comparing difference are not significantly (P > 0.05), administration phase and convalescent period histological examination high dose group animal main organs compare with blank group and have no notable difference, have no slowness toxicity to occur.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with matched group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safety range of the present invention is comparatively large, is a kind of safe and reliable health product.

Pharmacological experiment:

Folium Apocyni Veneti is cold in nature. and sweet in the mouth, hardship, suppressing the hyperactive liver is calmed the nerves, clearing away heat and promoting diuresis.Main component rutin, catechu rope, isoquercitrin rope, glutamic acid, alanine, valine, potassium chloride etc., wherein antihypertensive compositions is Quercetin, total flavones, there is blood pressure lowering, strengthen capillary resistance, reduce capillary fragility, fall that blood refers to, coronary artery dilator, increase coronary artery blood flow effect.Pharmacological action: Folium Apocyni Veneti decoct has hypotensive effect; Root of Apocynum venetum L. decoct has cardiotonic; Folium Apocyni Veneti extractum has calmness, anticonvulsant action, and has stronger diuresis, reduction blood fat, immunity moderation, defying age and suppress the effects such as influenza virus.This experiment is intended to the enhancing immune effect effect of the oral liquid health food of the present invention inquired into using Folium Apocyni Veneti as main material.

1 materials and methods

1.1 given the test agent: the present invention with Folium Apocyni Veneti, Herba Ecliptae, Radix Polygalae, Caulis Polygoni Multiflori, Fructus Gardeniae, Semen Ziziphi Spinosae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Corydalis, Herba Epimedii, Radix Codonopsis, Poria, Rhizoma Curcumae, Fructus Ligustri Lucidi, Fructus Corni, Concha Margaritifera, Herba Taxilli, the Radix Paeoniae Alba, Herb Gynostemmae Pentaphylli, Fructus Rosae Laevigatae, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Curculiginis, adds ethanol or water extraction, and the oral recommendation consumption of people is adult 3.6g every day, and amounting to dosage is 60mg/kgBW.

1.2 laboratory animals: healthy Male Kunming strain mice 200 (laboratory animal production licence number: SCXK (Shandong) 2008-0002 of SPF level selecting Shandong Province's medical experiment animal center breeding, the certification of fitness number: NO.0100382), body weight 18 ~ 22g.Animal housing's temperature: 22 ~ 25 DEG C, relative humidity: 55 ~ 70.Laboratory animal occupancy permit number: SCXK (Shandong) 2011-0005.

1.3 key instruments and reagent: instrument: animal balance, analytical balance, centrifuge, clean bench, CO2 gas incubator, microscope, microplate reader, agitator, thermostat water bath, semi-automatic biochemical analyzer etc.Reagent: RPMI RPMI-1640, calf serum, 2-ME, penicillin, streptomycin, ConA, isopropyl alcohol, MTT, Hank ' S liquid, PBS buffer, DNFB, complement (guinea pig serum), sheep red blood cell (SRBC) (SRBC), chicken red blood cell, Gimsa dye liquor, YAC 1 cell, EINECS 212-761-8, nitro tetrazolium chloride, PMS, oxidized form of nicotinamide-adenine dinucleotide, 0.2mol/L Tris-HCL buffer etc.

1.4 experimental technique

1.4.1 sample preparation and animal divide into groups to dispose: establish 300 according to the oral recommendation consumption of people, 600,1200mg/kg BW (being equivalent to 5,10,20 times of human body recommendation consumption respectively) basic, normal, high 3 dosage groups and a negative control group, often organize 50 animals.Take the present invention 1.5,3.0,6.0g respectively, respectively add pure water to 100mL, be made into 15,30,60g/L strength solution respectively, give corresponding dosage treated animal gavage respectively, gavage volume is 0.2mL/10g BW, and negative control group gives isopyknic pure water, every day gavage 1 time, continuous gavage 30 ~ 35d.

1.4.2 internal organs/weight ratio pH-value determination pH: experiment is end eventually, puts to death mice after weighing, takes out Thymus and spleen, electronic analytical balance is weighed, calculates dirty/body ratio.

The mouse spleen lymphocyte transformation experiment (mtt assay) of 1.4.3ConA inducing and NK cytoactive detection (LDH algoscopy): experiment is end eventually, often organize and get that 10 mices are aseptic gets spleen, divide two parts and make cell suspension, adjusting cell concentration is respectively 3X10 ⁶individual/mL (No. 1 suspension) and cell concentration are 2 × 10 ⁷/ mL (No. 2 suspensions).No. 1 suspension carries out lymphocytic multiplication capacity inspection by " mtt assay ", and multiplication capacity deducts by the optical density value adding ConA hole the optical density value not adding the lonely L of ConA and represents.With No. 2 suspensions for effector lymphocyte, get well-grown YAC 1 cell, adjustment cell concentration is 4 × 10 ⁵individual/mL detects by " LDH algoscopy " as target cell, calculates NK cytoactive.

1.4.4 mouse DTH experiment (ear swelling method) of dinitrofluorobenzene induction: experiment terminates front 5d and often organizes and get the depilation of 10 mouse part skins, with 50 " L DN-FB solution smears sensitization; after 5d, 1O L DNFB is smeared mouse right ear two sides and attack; put to death mice after 24h; with card punch take off left and right auricular concha 8mm diameter auricle, weigh, represent the degree of DTH with the difference of two auricle weight.

1.4.5 the mensuration (Hemagglutination Method) of serum hemolysin and antibody-producting cell detect (Jeme improves slide method): the Sanguis caprae seu ovis getting defiber, be made into the cell suspension of 2, experiment terminates front 5d and often organizes and get 10 mices, every Mus lumbar injection 0.2mL carries out immunity, carry out mouse orbit after 5d and get blood, observe by standard " Hemagglutination Method " mensuration that hemagglutination degree carries out serum hemolysin.Then put to death mice, get spleen and make cell suspension, 200 eye mesh screens filter, after washing 2 times by cell suspension in 5mL RPMI1640 culture fluid.Detect by " improvement slide method ", counting hemolysis plaque number, represent antibody-producting cell number with plaque number/full splenocyte, carry out antibody-producting cell detection.

1.4.6 mice carbonic clearance experiment: often organize and get 10 mices india ink that 1h dilutes through tail vein injection 4 times after last is to sample, every 10g body weight injection 0.1mL, timing immediately after prepared Chinese ink injects, in injection prepared Chinese ink after the 2nd minute and the 10th minute, " L joins 2mL0.1NazCO to get blood 20 from ophthalmic corner of the eyes venous plexus respectively.In solution, shake up.Blank is made, with semi-automatic biochemical analyzer with 600nm wavelength densitometric value (OD) with Na2CO solution.By sacrifice, get liver, spleen, weigh, calculate phagocytic index.

1.4.7 Turnover of Mouse Peritoneal Macrophages engulfs chicken red blood cell experiment (half intracorporal method): experiment is end eventually, often organize and get 10 mouse peritoneal injection 2O (v/v, with normal saline) hematocrit chicken erythrocyte suspension, every Mus 1mL, interval 30min, cervical dislocation puts to death mice, detects by " half intracorporal method ", calculates phagocytic rate and phagocytic index.

1.5 results judge: the requirement according to health food evaluation is ridiculed, in cellular immune function, humoral immune function, monokaryon one macrophage function, NK cytoactive four, result is positive in any two, can judge that this given the test agent has enhancing immunity function.

1.6 data statisticss: application SPSS13.0 statistical software carries out variance analysis statistical disposition, and P < 0.05 has statistical significance for difference.

2 results

2.1 samples are on the impact of Mouse Weight and immune organ internal organs/body weight ratio: in experiment, the upgrowth situation of each group mice is good, each dosage group Mouse Weight and body weight increase and compare not statistically significant (P > 0.05) between negative control group, and physiology sign, outward appearance, behavior etc. are showed no exception.Thymus/the body weight of experiment various dose experimental group and spleen/body weight ratio and the equal not statistically significant of negative control group comparing difference (P > 0.05).

2.2 samples are on the impact of the cellular immunization of mice: the results are shown in Table 1.Table 1 shows, and the mouse spleen lymphocyte conversion capability that sample 3 dosage group ConA induce is all higher than negative control group, and wherein high dose group and negative control group comparing difference have statistical significance (P < 0.05).The delayed allergy (DTH) of sample 3 dosage group mices tests left and right auricle weight difference all higher than negative control group, and wherein high dose group difference compared with negative control group has statistical significance (P < 0.01).Judge that test for celluar immunity result is positive.

2.3 samples are on the impact of the humoral immunization of mice: the results are shown in Table 1.The antibody-producting cell number of sample each dosage group mice is all higher than negative control group, and wherein high dose group difference compared with negative control group has statistical significance (P < 0.05).The antibody product of sample each dosage mice serum hemolysin test is all higher than negative control group, and wherein high dose group difference compared with negative control group has statistical significance (P < 0.01).Display test for humoral immunity result is positive.

The every testing inspection result of table 1 mouse cell immunologic function, humoral immune function (-x ± s, mg/kg BW)

Note: compare with negative control group, * P < 0.05, * * P < O.01

2.3.1 sample is on the impact of monokaryon one macrophage phagocytic function of mice: the results are shown in Table 2.The phagocytic index of sample each dosage mouse monokaryon macrophage carbonic clearance test is all higher than negative control group.Wherein high dose group difference compared with negative control group has statistical significance (P < 0.05).The peritoneal macrophage of sample 3 dosage group mices, to the phagocytic rate of chicken red blood cell and phagocytic index no significant difference (P > 0.05) compared with negative control group, shows this result of the test negative.Show this sample to the mononuclear-macrophage phagocytic function of mice without obvious facilitation.

2.3.2 sample is on the impact of NK cells in mice activity: the results are shown in Table 2.The equal not statistically significant of NK cytoactive difference compared with negative control group (P > 0.05) of sample 3 dosage group mices, display NK cytoactive detection result is negative.

Table 2 mouse monokaryon macrophage phagocytic and NK cytoactive detection result (x ± S, mg/kg BW)

Note: compare with negative control group, * P < 0.05

3 discuss: under this laboratory condition, per os gives mice 300,600, the 30d of the present invention of 1 200mg/kg BW dosage, result shows its splenocyte that can promote mice and rises in value, transforms, and promotes mice delayed allergy, improves mouse antibodies cellulation number and serum hemolysin, promote mouse monokaryon macrophage carbonic clearance function, prompting the present invention has the health care of enhancing immunity.

Folium Apocyni Veneti is cold in nature. and sweet in the mouth, hardship, suppressing the hyperactive liver is calmed the nerves, clearing away heat and promoting diuresis.Main component rutin, catechu rope, isoquercitrin rope, glutamic acid, alanine, valine, potassium chloride etc., wherein antihypertensive compositions is Quercetin, total flavones, there is blood pressure lowering, strengthen capillary resistance, reduce capillary fragility, fall that blood refers to, coronary artery dilator, increase coronary artery blood flow effect.Pharmacological action: Folium Apocyni Veneti decoct has hypotensive effect; Root of Apocynum venetum L. decoct has cardiotonic; Folium Apocyni Veneti extractum has calmness, anticonvulsant action, and has stronger diuresis, reduction blood fat, immunity moderation, defying age and suppress the effects such as influenza virus.

Follow this thinking, adopt the present invention to subtract treatment neurasthenia, palpitation and insomnia achieves good curative effect.But must point out, neurasthenic morbidity main cause is still psychologic factors, after treatment by Chinese herbs obtains curative effect, still should focus on psychological health protection, adjustment is cognitive, improves bad coping style, just can avoid recurrence.Spermatogenesis of the present invention mends marrow, and benefiting QI and nourishing blood, strong brain is calmed the nerves.For the dizziness caused by deficiency of kidney-essence, deficiency of both QI and blood, weak, forgetful, insomnia; Neurasthenia, two diseases such as dry and astringent see above-mentioned patient.

Claims

1. a suppressing the hyperactive liver is calmed the nerves, improve the Folium Apocyni Veneti oral liquid of immunity, it is characterized in that, described Folium Apocyni Veneti oral liquid comprises the raw material of following parts by weight: Folium Apocyni Veneti 10 ~ 50 parts, Herba Ecliptae 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Semen Ziziphi Spinosae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, 10 ~ 20 parts, Poria, Rhizoma Curcumae 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Concha Margaritifera 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Fructus Rosae Laevigatae 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Rhizoma Curculiginis 10 ~ 20 parts.

2. suppressing the hyperactive liver is calmed the nerves according to claim 1, improve the Folium Apocyni Veneti oral liquid of immunity, it is characterized in that, in described Folium Apocyni Veneti oral liquid, the parts by weight of various raw material are: Folium Apocyni Veneti 10 ~ 30 parts, Herba Ecliptae 10 ~ 15 parts, Radix Polygalae 10 ~ 15 parts, Caulis Polygoni Multiflori 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, Semen Ziziphi Spinosae 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Rhizoma Corydalis 10 ~ 15 parts, Herba Epimedii 10 ~ 15 parts, Radix Codonopsis 10 ~ 15 parts, 10 ~ 20 parts, Poria, Rhizoma Curcumae 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Concha Margaritifera 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Fructus Rosae Laevigatae 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Rhizoma Curculiginis 10 ~ 20 parts.

3. suppressing the hyperactive liver is calmed the nerves according to claim 1, improve the Folium Apocyni Veneti oral liquid of immunity, it is characterized in that, in described Folium Apocyni Veneti oral liquid, the parts by weight of various raw material are: Folium Apocyni Veneti 10 ~ 50 parts, Herba Ecliptae 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Semen Ziziphi Spinosae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, 10 ~ 15 parts, Poria, Rhizoma Curcumae 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, Concha Margaritifera 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, the Radix Paeoniae Alba 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 10 ~ 15 parts, Fructus Rosae Laevigatae 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Rhizoma Curculiginis 10 ~ 15 parts.

4. as described in any one of claims 1 to 3 item, suppressing the hyperactive liver is calmed the nerves, improves the preparation method of Folium Apocyni Veneti oral liquid for immunity, and it is characterized in that, the preparation process of described Folium Apocyni Veneti oral liquid comprises following aspect:

5. prevent and treat suppressing the hyperactive liver according to claim 4 to calm the nerves, improves the preparation method of Folium Apocyni Veneti oral liquid of immunity, it is characterized in that, in described step a, Folium Apocyni Veneti of gathering in annual summer, has plucked to spread out and has shone or dry, sieved discarding stalk, raise clean impurity; Add in the ethanol accounting for its quality 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, then puts into concentrating under reduced pressure tank, decompression recycling ethanol, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06 extractum, become component 1.

6. suppressing the hyperactive liver is calmed the nerves, improves the preparation method of Folium Apocyni Veneti oral liquid of immunity according to claim 4, it is characterized in that, in described step b, all the other raw medicinal materials are mixed, put into the ethanol accounting for its quality 10 times amount to soak more than 24 hours, 2 extracting solution each 1 ~ 2 hour, are merged and leave standstill by heating and refluxing extraction 2 times; The medicinal residues of the medical material crossed by above-mentioned ethanol extraction again add the water heating and refluxing extraction 2 times accounting for its quality 10 times amount, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill; Above-mentioned two kinds of extracting solution are merged, as component 2.

7. suppressing the hyperactive liver is calmed the nerves, improves the preparation method of Folium Apocyni Veneti oral liquid of immunity according to claim 4, it is characterized in that, in described step c, the component 1 above-mentioned steps obtained mixes with component 2, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the extractum of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, extractum is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.2g crude drug amount; Unguentum after concentrated adds Mel and is modulated into oral liquid.

8. according to any one of claims 1 to 3, suppressing the hyperactive liver is calmed the nerves, improves the preparation method of Folium Apocyni Veneti oral liquid for immunity, and it is characterized in that, its preparation process can also be:

A. the preparation of Folium Apocyni Veneti;

9. suppressing the hyperactive liver is calmed the nerves, improves the preparation method of Folium Apocyni Veneti oral liquid of immunity according to claim 8, it is characterized in that, in described step a, to gather Folium Apocyni Veneti in annual early June to early October, then spread out and shine or dry, sieve discarding stalk, raises clean impurity; Dry in the sun is good, for subsequent use, also can pluck in rear iron pan the 10-15 minute that stir-fries, knead.

10. suppressing the hyperactive liver is calmed the nerves, improves the preparation method of Folium Apocyni Veneti oral liquid of immunity according to claim 8, it is characterized in that, in described step b, getting all crude drug steeps in ethanol, add in the ethanol accounting for its quality 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use; In described step c, extractum above-mentioned steps obtained is inserted in economic benefits and social benefits vacuum concentrator, and when being concentrated into 80 DEG C, relative density is the extractum of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, extractum is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.2g crude drug amount; Unguentum after concentrated adds Mel or dextrin is modulated into oral liquid, canned.