CN104397282A

CN104397282A - Tranquilization and brain tonifying eleutherococcus senticosus healthare tea and preparation method thereof

Info

Publication number: CN104397282A
Application number: CN201410698912.0A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Shen Da New And High Technology Development Corp Ltd
Current assignee: Qingdao Shen Da New And High Technology Development Corp Ltd
Priority date: 2014-11-27
Filing date: 2014-11-27
Publication date: 2015-03-11

Abstract

The invention discloses tranquilization and brain tonifying eleutherococcus senticosus healthare tea, which comprises the raw medicaments in parts by weight: 10 to 50 parts of eleutherococcus senticosus, 10 to 20 parts of polygala tenuifolia, 10 to 20 parts of tuber fleeceflower stems, 10 to 20 parts of dried radix rehmanniae, 10 to 20 parts of gardenia, 10 to 20 parts of poria with hostwood, 10 to 20 parts of nacres, 10 to 20 parts of acorus gramineus, 10 to 20 parts of walnuts, 10 to 20 parts of radix paeoniae rubra, 10 to 20 parts of lyceum barbarum, 10 to 20 parts of semen zizphi spinosae, 10 to 20 parts of albizia julibrissin, 10 to 20 parts of atractylodes, 10 to 20 parts of platycladi seeds, 10 to 20 parts of mulberries, 10 to 20 parts of salvia miltiorrhiza, 10 to 20 parts of radix polygonum multiflorum preparata, 10 to 20 parts of epimedium herb and 10 to 20 parts of gynostemma pentaphyllum. The tranquilization and brain tonifying eleutherococcus senticosus healthcare tea has significant anti-fatigue effects as well as the effects of tonifying the brain, tranquilization, engendering essence, supplementing marrow, removing liver-fire, improving eyesight, reinforcing qi and nourishing blood, is completely a healthy and environment-friendly healthcare product, and is used for the symptoms of neurasthenia, insomnia, amnesia, dizziness and the like, and stamina, ability, alertness and learning ability can be enhanced.

Description

Acanthopanax root health tea of a kind of Anshen Bunao and preparation method thereof

Technical field

The present invention relates to the health products containing deriving from plant, animal or mineral component, particularly a kind of acanthopanax root health tea and preparation method thereof of Anshen Bunao.

Background technology

Brain worker is the people at highest risk of inferior health, and according to an investigation display, the brain worker of nearly 90% is in sub-health state in various degree.This is because brain is human body the most accurate " instrument ", and brain worker bears the firm static work of single posture for a long time, makes muscle be in the state of constant tension, easily causes qi and blood stagnation, cerebral blood supply insufficiency, thus bring out various disease.

Hunt for a job, promote, house, pay rise, sufferer, child education, every aspect life trival matters make modern worn out mentally and physically, sensation health unable to make ends meet.Add modern metropolitan cities working clan and generally use computer office, tobacco and wine are immoderate, and night life is uncontrolled, stay up late, and these have all directly injured liver kidney.Look for a long time and radiation, the eye health for computer gang has buried hidden danger.This kind of people needs to protect liver while attention eye hygiene and nourishes blood.The living and diet of modern people is too meticulous, and amount of exercise reduces, or eats and drinks immoderately, or overstrain, body metabolism function is failed gradually, causes visceral dysfunction, easily produce sleeping problems.Want to sleep well may become a lot of white collar, the extravagant hope of the gang that requires mental skill.

Social environmental pollution is serious, and life stress is large, makes a lot of people feel all not sleep well at urban life pressure; Adding modern metropolitan cities working clan generally uses computer office to look for a long time, tobacco and wine are immoderate, the behavior of the injury liver kidneys such as night life is uncontrolled, stay up late, the provisions that eyes are subject to blood just can look thing, and excessively use eye, can liver-blood deficiency be made, make binocular can not get the supply of nutrition, thus go out to lose face dry and astringent, see thing is fuzzy, yctalopia etc.In addition, long-term sitting eye, except binocular blood supply insufficiency, cervical vertebra, lumbar vertebrae also can produce strain, less than alleviation, also can must cause damage to liver.

Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, add that long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, the agricultural chemicals remained in the absorption of a large amount of three height (high heat, high protein, higher fatty acid), more than three (anticorrisive agent is many, flavoring agent is many, hormone many) food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and amount of exercise less than normal, obesity and diabetes have just become the rich man's disease of city gang.Work hard, the difficulty in lasting nervous, worried, working and learning, mental labour heavy for a long time, as with unhealthy emotion, more allows people feel dog-tired.

Wilsonii has another name called slender acanthopanax ginseng, and modern medicine research proves that its special efficacy is substantially identical with ginseng can improving water flood, raising sleep quality, treatment hypertension, high fat of blood, diabetes, cerebral thrombus, coronary heart disease antirheumatic, anti-ageing, antifatigue, strengthens immunologic function.

Modern medicine research proves that the action character of wilsonii is substantially identical with ginseng, has and regulates body disorderly, make it to be tending towards normal function.Have good antifatigue effect, comparatively ginseng is remarkable, and significantly can improve hypoxia-bearing capability.Bowl spares, benefit essence, strong will, wines used as antirheumatic, strengthen the bone, blood circulation and promoting silt, the function such as stomach invigorating diuresis.Clothes of a specified duration " are made light of one's life by commiting suicide and are endured hardships ".Wilsonii contains noticeable composition---and eleutheroside, it can stimulate mind & body vigor.Numerous scientific publications about wilsonii demonstrates its antifatigue effect, strengthens endurance and ability, increases alert and resourceful and learning ability.Numerous usage obtains confirmation all in human experimentation.Wilsonii is rehabilitation after being ill, bears too much pressure or anxiety, works excessive, chronic disease cause weakly crowd and those need to reach very welcome self-medication medicine in the people on physiology and psychological performance peak.It has support immune system to have the report of considerable quantity to point out, recovers improper low blood pressure, improves the circulatory system, makes disorderly glycolipid metabolism normalization, liver, testis, anabolic effect of bone density and other vitals.

Does the tea that wilsonii is made have what effect and effect? radix Acanthopanacis senticosi tea is containing multiple glucoside, wherein part glucoside and panaxoside have similar physiologically active, there is antifatigue (antifatigue effect of eleutheroside is also stronger than ginseng), add essence benefit marrow and anti-ageing, soothing nerves and assisting sleep dormancy effect of fostering the spirit of nobility, being the useful health drink of drink, is the first-class natural beverage of the elderly and presenting friends.Effect of radix Acanthopanacis senticosi tea in ancient times just known by people, effect that " Mingyi Bielu " describes wilsonii to be had " bowl spares benefit essence, hard muscles and bones, strong will ".Therefore ancients have saying of " Ning get Yi, slender acanthopanax, not wanting the full car of gold and jade "; Wilsonii sees Shennong's Herbal, is classified as top grade; Top grade is refer to nontoxic, and for a long time clothes can be made light of one's life by commiting suicide, to be promoted longevity and harmless.Therefore radix Acanthopanacis senticosi tea also can as daily drink, can Long-Time Service.

Various foster protecting liver, the health products of Anshen Bunao, medicine spread unchecked on the market now, but great majority are had a good apperance only, false propaganda on a grand scale, probably without any health care, but cause the huge injury of the person, therefore, the health products of the effective liver protecting of search of health, Anshen Bunao have very real significance.Chinese medicine liver protecting, Anshen Bunao have advantage that is nontoxic, that can be absorbed completely by organism, are the Main way that we study.

Summary of the invention

Various foster protecting liver, the health products of Anshen Bunao, medicine spread unchecked on the market now, but great majority are had a good apperance only, false propaganda on a grand scale, probably without any health care, but cause the huge injury of the person, therefore, the health products of the effective liver protecting of search of health, Anshen Bunao have very real significance.Chinese medicine liver protecting, Anshen Bunao have advantage that is nontoxic, that can be absorbed completely by organism, are the Main way that we study.Modern medicine research proves that the action character of wilsonii is substantially identical with ginseng, has and regulates body disorderly, make it to be tending towards normal function.Have good antifatigue effect, comparatively ginseng is remarkable, and significantly can improve hypoxia-bearing capability.Bowl spares, benefit essence, strong will, wines used as antirheumatic, strengthen the bone, blood circulation and promoting silt, the function such as stomach invigorating diuresis.Clothes of a specified duration " are made light of one's life by commiting suicide and are endured hardships ".Wilsonii contains noticeable composition---and eleutheroside, it can stimulate mind & body vigor.Numerous scientific publications about wilsonii demonstrates its antifatigue effect, strengthens endurance and ability, increases alert and resourceful and learning ability.The present invention is the health products of green health environmental protection completely.The present invention is the health protection tea of being made up of medicines such as wilsonii, polygala root, RADIX POLYGONI MULTIFLORI PREPARATA, barrenwort, the radix paeoniae rubrathe, has invigorating brain and relieving mental uneasiness, and production of sperm mends marrow, the effect of the nourishing qi and blood that clears liver and improve vision, for neurasthenia, insomnia, the disease such as forgetful, dizzy.

For solving above-mentioned technical barrier, the invention provides a kind of acanthopanax root health tea of Anshen Bunao, acanthopanax root health tea described in it comprises the bulk drug of following parts by weight: wilsonii 10 ~ 50 parts, polygala root 10 ~ 20 parts, Polygonum multiflower knotweed 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, cape jasmine 10 ~ 20 parts, fushen 10 ~ 20 parts, mother-of-pearl 10 ~ 20 parts, grass-leaved sweetflag 10 ~ 20 parts, walnut 10 ~ 20 parts, the radix paeoniae rubrathe 10 ~ 20 parts, matrimony vine 10 ~ 20 parts, spina date seed 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, the seed of Oriental arborvitae 10 ~ 20 parts, mulberries 10 ~ 20 parts, the red sage root 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, barrenwort 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts.

The acanthopanax root health tea of described Anshen Bunao, the bulk drug of following parts by weight can be comprised: wilsonii 10 ~ 30 parts in acanthopanax root health tea described in it, polygala root 10 ~ 15 parts, Polygonum multiflower knotweed 10 ~ 15 parts, cape jasmine 10 ~ 15 parts, cape jasmine 10 ~ 15 parts, fushen 10 ~ 15 parts, mother-of-pearl 10 ~ 15 parts, grass-leaved sweetflag 10 ~ 15 parts, walnut 10 ~ 15 parts, the radix paeoniae rubrathe 10 ~ 15 parts, matrimony vine 10 ~ 20 parts, spina date seed 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, the seed of Oriental arborvitae 10 ~ 20 parts, mulberries 10 ~ 20 parts, the red sage root 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, barrenwort 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts.

The acanthopanax root health tea of described Anshen Bunao, the bulk drug of following parts by weight can also be comprised: wilsonii 10 ~ 40 parts in acanthopanax root health tea described in it, polygala root 10 ~ 20 parts, Polygonum multiflower knotweed 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, cape jasmine 10 ~ 20 parts, fushen 10 ~ 20 parts, mother-of-pearl 10 ~ 20 parts, grass-leaved sweetflag 10 ~ 20 parts, walnut 10 ~ 20 parts, the radix paeoniae rubrathe 10 ~ 20 parts, matrimony vine 10 ~ 15 parts, spina date seed 10 ~ 15 parts, Flos Albiziae 10 ~ 15 parts, the bighead atractylodes rhizome 10 ~ 15 parts, the seed of Oriental arborvitae 10 ~ 15 parts, mulberries 10 ~ 15 parts, the red sage root 10 ~ 15 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 15 parts, barrenwort 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of acanthopanax root health tea of Anshen Bunao, and described in it, the preparation process of acanthopanax root health tea comprises following aspect:

A. first the acanthopanax plucked is cleaned and dry, then put into roller fixation machine and complete;

B. the electric frying pan put into by acanthopanax after terminating that completes stir-fries shaping;

C. shaping acanthopanax is put into and is carried camera Titian;

D. all the other bulk drugs described are prepared into granule or pulvis,

E. by the acanthopanax prepared and the granule obtained or pulvis mixing, pack shaping.

In described step a, can pluck wilsonii tender leaf spring every year, first the free of contamination acanthopanax of anosis worm plucked be put into water and rinse, after taking out, airing is on ventilative bamboo mat, and upset airing 7-12 hours, parches collection; The acanthopanax that airing is good is put into roller fixation device complete, complete 20-30 minute at 70-80 DEG C.

In described step b, naturally dry in the shade after the acanthopanax after completing can being taken out, put into large iron pan and knead, knead on first backward downwards, firmly want evenly, when filament leaf bar rope is comparatively tight, the baking machine turning in putting into 50-60 DEG C when becoming dark brown fry 20-30 minute shaping.

In described step c, the acanthopanax stir-fried can be dried naturally, put into fragrance extracting machine Titian 20-30 minute, temperature controls in 50-60 DEG C, naturally dries after taking out.

In described steps d, the preparation method making granule when all the other bulk drugs is: surplus stock medicine component is put into the ethanol accounting for its quality 10 times amount, heating and refluxing extraction 2 times, each 1-2 hour, removes supernatant, merge extract, 100-110 order filters, then is the ultrafiltration post ultrafiltration of 6000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use; The dregs of a decoction of the component bulk drug medicinal material crossed by above-mentioned alcohol extract again add the water heating and refluxing extraction 2 times accounting for its quality 10 times amount, remove supernatant, merge extract, 100-110 order filters, be the ultrafiltration post ultrafiltration of 6000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating be concentrated into paste, stand for standby use; Extract medicinal extract by above-mentioned two kinds to merge, reducing pressure after reclaiming ethanol, it is concentrated to put into inspissator, by gained concentrate adjustment proportion to 1.40; reduce pressure to obtain medicinal extract; put into dryer to dry, then add honey or dextrin mediation, put into the granule that granulator makes 0.1-0.2 centimetre.

In described steps d, the preparation method making pulvis when all the other bulk drugs is: get all the other bulk drugs and steep in water, soaks more than 2 hours, adds 8 times amount of bulk drug medicine gross weight respectively, the water extraction of 6 times amount gets 2 times, and extraction time is 2 hours, 1 hour; Merge No. 2 extracts, extract is centrifugal by tubular type, obtains centrifugate, and centrifugate is crossed D 101 macroreticular resin and adsorbed, and first washes removal of impurities with water, then carries out wash-out with the ethanol of 70%, collects eluent, reduced pressure concentration, and one-tenth medicinal extract, for component becomes 1; The dregs of a decoction of bulk drug medicine said extracted crossed add ethanol, add respectively 10 times amount of dregs of a decoction gross weight, 8 times amount ethanol temperature leaching 2 times, the warm leaching time is 2 hours, 1.5 hours, and temperature is 85 DEG C, merges 2 warm immersion liquid; Temperature immersion liquid is evaporated to 1.25 medicinal extract when density is 60 DEG C, and medicinal extract is added the extraction into ethyl acetate secondary of its 4 times amount, extract has reclaimed ethyl acetate, becomes medicinal extract, obtains component 2; Above-mentioned two kinds of extraction components are merged, when reduced pressure concentration relative density is 80 DEG C 1.35 filtrate, reclaim ethanol, above-mentioned two kinds of extracts are inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.60, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, mixes the fine powder sieved.

In described step e, can will obtain granule or pulvis mixes with the acanthopanax that above-mentioned steps makes in steps d, after ultraviolet sterilization, pack packaging is shaping.

Wilsonii bowl spares, benefit essence, strong will, wines used as antirheumatic, strengthen the bone, blood circulation and promoting silt, the function such as stomach invigorating diuresis.Clothes of a specified duration " are made light of one's life by commiting suicide and are endured hardships ".Does the tea that wilsonii is made have what effect and effect? radix Acanthopanacis senticosi tea is containing multiple glucoside, wherein part glucoside and panaxoside have similar physiologically active, there is antifatigue (antifatigue effect of eleutheroside is also stronger than ginseng), add essence benefit marrow and anti-ageing, soothing nerves and assisting sleep dormancy effect of fostering the spirit of nobility, being the useful health drink of drink, is the first-class natural beverage of the elderly and presenting friends.The present invention is the health products of green health environmental protection completely.Add the natural traditional Chinese medicine that some production of sperms mend marrow, nourishing qi and blood, by force brain are calmed the nerves, strengthening vital QI to eliminate pathogenic factors, logical internal organs lets out poison, promoting blood circulation to remove blood stasis, regulates the metabolic function of human body, has invigorating brain and relieving mental uneasiness, production of sperm mends marrow, the effect of the nourishing qi and blood that clears liver and improve vision, for neurasthenia, insomnia, the disease such as forgetful, dizzy.

Detailed description of the invention

Effect on central nervous system: wilsonii all has impact to the excitement of nervous centralis and process of inhibition, independent 1 administration demonstrates the spread effect of central nervous system, and successive administration then demonstrates strong effect.Wilsonii not only improves excited process, and strengthens process of inhibition, makes suppression be tending towards concentrated, makes differentiation more complete, increases corticocerebral process of intercentral inhibition.Its excitation principle is different from the compound of amphetamine, and not only toxicity is low, and does not upset normal sleep, and wilsonii quite has relation to neural functional status when neural excitement or suppression and medication and dosage size.

Antifatigue effect: extract and the glucoside of Radix Acanthopanacis Senticosi root all have antifatigue effect.The effect of glucoside comparatively phase extract is strong, and comparatively ginseng extract and panaquilon are strong.Lumbar injection wilsonii alcohol medicinal extract aqueous solution 20g/kg, average prolongation mouse swimming time 1/4.Caulis Et Caulis Acanthopanacis Senticosi severe edema due to hypofunction of the spleen extract 500mg/kg and syringaresinol-two-o-B-D-glycoside 50mg/kg thereof all can significant prolongation rat load swimming time.With the physiologically active of mouse rope climbing test determination Radix Acanthopanacis Senticosi root at different growing stage, display: the dry root of 1g in May is 79SUA33/g (excitation unit), July, active obviously decline, can reach maximum 116SUA33/g to August before fallen leaves.Acanthopanax also shows similar change (SUA33: animal used as test is compared with control-animal, the dosage delaying during exhaustion 33% is 1 SUA33).The extract of Radix Acanthopanacis Senticosi root and leaf can improve activities in rats energy 25% and 70% respectively.

Mulberries are improved skin (comprising scalp) blood supply, nutrition skin, make the effects such as the delicate and Wu Fa of skin, and can delay senility.Mulberries are that the elderly is healthy and strong U.S. face, antidotal good fruit and good medicine.Normal food mulberry fruit can improving eyesight, the symptom that relieving eye strain is dry and astringent.Mulberries have immunologic enhancement.Mulberries have effect of gain to spleen, have humidification to hemolytic reaction, can prevent human body artery sclerosis, skeletal joint sclerosis, enhance metabolism.It can promote the growth of erythrocyte, prevents Neuroleptic Leukocytopenia, and has auxiliary effect to illnesss such as treatment diabetes, anaemia, hypertension, high fat of blood, coronary heart disease, neurasthenia.Mulberry fruit has promoting the production of body fluid to quench thirst, promotes digestion, helps the effects such as defecation, and proper amount of edible can promote gastric secretion, stimulates enterocinesia and removes scorching.Motherland's medical science is thought, mulberries are sweet in flavor and cold in property, there is liver-kidney tonifying, ease constipation of promoting the production of body fluid, the effect such as black invention order.

Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body.Baizhu volatile oil has inhibitory action to mouse EC, lymphosarcoma ascitic type, the cancer of the esophagus (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also remarkable inhibitory action is had." property of medicine opinion " carries it: monarch, taste is sweet, pungent, nontoxic.Energy main large wandering arthritis, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken place food that disappears, appetizing, removes sputum, except fever and chills, lets out under stopping.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells to vomit inverse, and crymodynia in abdomen, vomits and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.

Polygala root (Radix Polygalae) is conventional Chinese medicine, be recorded in Shennong's Herbal the earliest, be classified as top grade, and be regarded as supporting life key medicine, derive from the dry root of milk wort polygala root PolygalatenuifoliaWilld. and ovum leaf polygala root P.sibiricaL..Warm in nature, bitter, pungent, the function of have intelligence development of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep caused for breakdown of the normal physiological coordination between the heart and the kidney, forgetful palpitation with fear, wandering, expectoration is not well, sore swollen toxin, mastosis.Shennong's Herbal: master coughs in inverse wound, and tonifying for the deficiency, except perverse trend, sharp nine orifices, intelligence development is intelligent, normal hearing and eyesight, does not forget, strong will times power.

Polygonum multiflower knotweed, latin name: medicinal material Caulis Polygoni Multiflori former Plant-Polygonum Polygonum multiflorumThunb. effect: nourish heart, calm the nerves, dredging collateral, dispel the wind, cure mainly: control insomnia, internal lesion caused by overexertion, hidrosis, deficiency of blood bodily pain, ulcer, scrofula, wind sore mange.Meridian distribution of property and flavor: sweet micro-hardship is flat.Compatibility of drugs: complex acid jujube kernel, grows the heart-yin, the peaceful mind; Join the dried rhizome of rehmannia, tonifying yin of nourishing blood; Join lucid asparagus, the tuber of dwarf lilyturf, the clear fire of deficiency type, nourish heart the moon; Join notopterygium root, levisticum, expelling wind and eliminating dampness, Shu Li joint.Have a sleepless night for dysphoria.Polygonum multiflower knotweed has nourishing blood and tranquilization effect, is main, often coordinates with cortex albiziae mutual reinforcement between, also can be equal to jujube kernel, the seed of Oriental arborvitae, polygala root and use for the few caused insomnia of deficiency of Yin blood.

Fushen is the Chinese herbal product of plant Poria cocos; For Polyporaceae crouches the sclerotium of hole platymiscium Poria cocos [(Poriacocos Schw.) Wolf], original kind is rudimentary plant, is the fungi colonized on pine tree.Medicinal effects is the white portion entertaining pine stump in the middle of dry sclerotia body.Nature and flavor are sweet, light flat.There are the functions such as excreting dampness, invigorating the spleen, Ning Xin.For phlegm and retained fluid, oedema, difficult urination, have loose bowels, palpitaition, dizzy.Taste is sweet, light, property is put down, and is used as medicine and has the function of clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Nature and flavor are sweet, light flat.There are the functions such as excreting dampness, invigorating the spleen, Ning Xin.For phlegm and retained fluid, oedema, difficult urination, have loose bowels, palpitaition, dizzy.Fuling peel, inducing diuresis for removing edema, the diseases such as the edema that wets for water, for palpitation with fear of having a guilty conscience, forgetful, insomnia, frightened epilepsy, difficult urination." not Lu ": treat wind dizzy, wind be empty, the exhaustion or lesion of the five internal organs, dry.Only palpitation with fear, is enraged more, forgetful.Happy intelligence development, supports spirit.

Mother-of-pearl is the powder of shellfish nacre, has calming the liver; To calm the nerves arresting convulsion; The effect of clearing liver and improving vision.Salty, cold.Return liver, the heart channel of Hang-Shaoyin.Calming the liver; To calm the nerves arresting convulsion; To clear liver and improve vision textual criticism.Function cures mainly flat liver, checking exuberance of yang, arresting convulsion, hemostasis.Control dizzy, tinnitus, palpitaition, insomnia, demented, frightened epilepsy, spits blood, bleeding from five sense organs or subcutaneous tissue, metrorrhagia." Chinese medicine voluminous dictionary ": nourishing liver is cloudy, clearing away the liver-fire.Control demented frightened epilepsy, dizzy, tinnitus, heartbeat, pleuroperitoneum is swollen, women's blood-head, metrorrhagia, and frightened the jerking of children's sends out a convulsion." medicine materical crude slice is newly joined ": calming the liver, soul of calming the nerves, arresting convulsion epilepsy, disappear hot ruffian, mist.

Record in a spina date seed China medicine book Shennong's Herbal the earliest: " bowl spares benefit liver, hard muscles and bones, helps cloudy gas, and all the merit of spina date seed also." record in Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica, " insomnia due to insufficiency of the gallbladder-qi in ripe treatment, the disease of polydipsia abnormal sweating for jujube kernel; Life is treated gallbladder-heat and is slept well, and all foot faints cloudy few positive medicine also.Effect nourishing the liver, Ning Xin, calms the nerves, arrest sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation, polydipsia, abnormal sweating." herbal classic ": main trusted subordinate's fever and chills, evil knot gas gathers, painful limbs, arthritis with fixed pain caused by dampness." not Lu ": mainly vexatiously must not to sleep, navel is pain up and down, and blood turns to be let out for a long time, abnormal sweating polydipsia, bowl spares, beneficial irritability, and hard muscles and bones helps cloudy gas, makes us fertile strong." property of medicine opinion ": main muscles and bones wind, fries end and takes it as soup.Supplement to the Herbal: many lifes of sleeping make, and must not sleep and fry.Wang Haogu: control milk-livered egersis, trembles with fear also, fries clothes; Control somnolence due to gallbladder-excess, heat also, use by life." book on Chinese herbal medicine converges and says ": astringe qi is calmed the nerves, and flourish muscle supports marrow, and stomach fortune spleen." book on Chinese herbal medicine is new again ": flat liver and qi, moistens the lung and nourish yin, dampness removing in temperature, astringe qi hidroschesis, and beneficial will is breathed out surely, hearing-improing and eyesight improving.Pharmacological action:. calm, syngignoscism: oral or lumbar injection all behaves with composure and somnolence spina date seed decoction to big white mouse, no matter daytime or night, spina date seed all can show above-mentioned effect.Calm index when small white mouse is oral is 1.95, shows act synergistically with barbiturate, and after spina date seed is used continuously 6 days, animal sleep can shoal, and namely decreased duration produces tolerance, but drug withdrawal can disappear after 1 week.

The radix paeoniae rubrathe enters liver, the spleen channel, nourishing blood and liver, pain relieving in slow, and astringe yin receives sweat.Control chest abdomen pain over the hypochondriac region, rush down dysentery stomachache, spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, under band, married woman's blood closes obstructed, and disappear hemostasis, can lose purulence, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, brings down a fever, relieving restlessness, beneficial gas, the capable hot disease in sky, pest miasma, frightened mad, and married woman's blood is transported, and intestines wind, rushes down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, sore scabies, headache, improving eyesight, hot eyes exerts meat.The many tonifying Qi of redness of the skin or complexion person, white person controls blood.

Cape jasmine: another name Yellow Fructus Gardeniae, mountain Cape jasmine, white toad are the fruits of madder wort cape jasmine.At present, the fruit of cape jasmine is traditional Chinese medicine, and the l belonging to Ministry of Public Health's promulgation criticizes medicine-food two-purpose resource, has effects such as protecting liver, cholagogic, step-down, calmness, hemostasis, detumescence.The diseases such as treatment icteric hepatitis, bruise, hypertension, diabetes are usually used at tcm clinical practice.Pyreticosis is vexed.This product bitter cold is fallen clearly, can rush down clearly three burnt fire-evil, purge the sthenic heart-fire and relieving restlessness, the key medicine that pyreticosis is vexed in order to control, dysphoria is not peaceful, can use same with Fermented Soybean, as Decoction of Capejasmine and Fermented Soybean treatise on Febrile Diseases; If join the root of large-flowered skullcap, the coptis, golden cypress etc., available to control pyreticosis fire poison flourishing, three burnt all heat and see that high heat is irritated, coma and delirium person, as huanglian jiedu decoction " outer cape jasmine platform is secret to be wanted ".

Flos Albiziae nature and flavor are sweet, flat.There is the merit of Xie Yu and blood, Ning Xin, subduing inflammation.Have and control that confused and worried, melancholy, insomnia, lung carbuncle, carbuncle are swollen, the effect of scrofula, injured bone.Cortex albiziae is the bark of legume silk tree, cortex albiziae another name close confused skin, night platform skin, albizzia skin, cortex albiziae has the Xie Yu that calms the nerves, effect of carbuncle of disappearing of invigorating blood circulation, cortex albiziae has treats confused and worried, melancholy, egersis, inside and outside large carbuncle, traumatic injury effect, gastritis sufferer is careful takes cortex albiziae, and wind-heat spontaneous perspiration, diseases caused by external factors egersis person taboo take cortex albiziae." herbal classic ": main five viscera settling, and will, makes us happy carefree.Supplement to the Herbal: desinsection.

Sealwort: sealwort is used as medicine with rhizome.There is boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney benefiting functions.Be used for the treatment of weakness of the spleen and the stomach, fatigue and asthenia, dry food is few, deficiency syndrome of the lung cough caused by dryness, asthenia of essence and blood, and interior heat such as to be quenched one's thirst the disease.Very effective in cure for diabetes.Sealwort has hypotensive, hypoglycemic, reducing blood lipid, atherosclerosis, and delay senility and effect such as antibacterial grade, Siberian solomonseal rhizome polysaccharide has Immunestimulatory effect.For the lung-dryness syndrome due to yin deficiency, the few phlegm of dry cough, and the labor of lung-kidney deficiency is coughed chronic cough etc.For weakness of the spleen and the stomach.Both tonifying spleen-yin, again beneficial temper, obtain dizzy, soreness and weakness of waist and knees for deficiency of kidney essence, poliosis and quenching one's thirst.Sealwort strengthens the bone, beneficial marrow, bleaches and sends out; The cough phlegm be suitable for caused by lack of lung-YIN is few, dry cough without phlegm, the diseases such as hemoptysis.

RADIX POLYGONI MULTIFLORI PREPARATA: the Chinese medicine fleece-flower root have Radix Polygoni Multiflori and RADIX POLYGONI MULTIFLORI PREPARATA point, direct slicing is used as medicine for Radix Polygoni Multiflori, dries be used as medicine for RADIX POLYGONI MULTIFLORI PREPARATA with black soya bean liquor after mixing steaming.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, the carbuncle that disappears, relax bowel, and is usually used in treatment scrofula sore carbuncle, rubella itch, the dry constipation of intestines; The filling liver kidney of RADIX POLYGONI MULTIFLORI PREPARATA function, benefiting essence-blood, black beard and hair, strengthening the bones and muscles, under sallow for the deficiency of blood, dizzy tinnitus, poliosis, soreness and weakness of waist and knees, extremity numbness, uterine bleeding band, chronic malaria body is empty etc.RADIX POLYGONI MULTIFLORI PREPARATA of the present invention is the good merchantable brand of invigrating kidney.

Barrenwort is Chinese conventional Chinese medicine, has very high medical value, perennial herb, and enriching yin is taken a tonic or nourishing food to build up one's health, and establishing-Yang is kept fit.Bitter and puckery flavor, suitable insomniac uses.Herb hyoscine.Cure mainly impotence and premature ejaculation, pain in low back and legs, numb limb, hemiplegia, neurasthenia, forgetful, tinnitus, dizzy disease such as grade.Excessive sheep flower bud is Chinese conventional Chinese medicine.

Grass-leaved sweetflag dampness elimination is whetted the appetite, open-minded phlegm of having one's ideas straightened out, inducing resuscitation intelligence development.Not hungry for gastral cavity ruffian, mouth of keeping silent _underdysentery, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, coma due to blocking of the respiratory system, pyreticosis coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, wind-cold-dampness arthralgia, swollen ulcer drug, traumatic injury.

Walnut taste is sweet, property is put down, temperature, nontoxic, and micro-hardship is micro-puckery.Walnut taste is sweet, warm in nature, enters kidney, lung, large intestine channel.Can kidney tonifying, the strong waist of controlling nocturnal emission with astringent drugs, warm lung Dingchuan, relax bowel.Cure mainly: suffer from a deficiency of the kidney breathe heavily cough, pain in the back; (in core wooden interlayer) bitter, warm in nature; Kidney tonifying, puckery essence.Dissipating blood stasis with potent drugs: for amenorrhea due to stagnation of blood, abdominal pain due to blood stasis, store blood and go mad, fall and beat the illness such as stasis of blood energy.Moisturize laxation: the stool for the dry constipation of intestines is difficult to resolve.This product hardship lets out the loose stasis of blood, enters Liver Channel blood system, has stronger promoting blood circulation for regulating menstruation, the merit of removing blood stasis for promoting tissue regeneration, is suitable for the stagnant comparatively severe one of the blood system stasis of blood.In addition, the merit of ease constipation, cough-relieving is had concurrently.The strong body of qi-restoratives, provides nutrition: prove through zoopery, containing the mixing-in fat diet of nut oil, body weight can be made to increase, and seralbumin increases, and blood cholesterol levels raises comparatively slow, therefore walnut is the tonic product of rare a kind of higher fatty acid property material.

Its taste of the fruit of Chinese wolfberry is sweet, the flat effect with liver-kidney tonifying of property, says and " take hard muscles and bones for a long time, make light of one's life by commiting suicide not old, resistance to cold and heat in Compendium of Material Medica." traditional Chinese medical science commonly use it treating liver-kidney Yin deficiency, soreness and weakness of waist and knees, dizziness, forgetful, dizzy, the many tear of blurred vision, quench one's thirst, the illness such as seminal emission.Modern pharmacology research confirm the fruit of Chinese wolfberry adjustable body's immunity, can effectively Tumor suppression grow and cell mutation, have delay senility, AFL, adjusting blood lipid and blood sugar, the aspect such as promotion hematopoiesis function effect, and be applied to clinical.Fruit of Chinese wolfberry taking convenience, can be used as medicine, chews clothes, steep in wine.But outer domination of pathogen heat, insufficiency of the spleen have the wet and person of having loose bowels to avoid clothes.

Gynostemma pentaphylla bitter; Micro-sweet; Cool in nature.Hypertension, high fat of blood, hyperglycaemia can be treated, the diseases such as fatty liver.There is effect of protecting liver and detoxication, hypotensive, reducing blood lipid blood sugar.It is gynosaponin, gynostemma pentaphylla glucoside (polysaccharide), water-soluble amino acids, flavonoids, multivitamin, trace element, mineral matter etc. that gynostemma pentaphylla mainly contains effective constituent.Return lung; Spleen; Kidney channel.Replenish qi to invigorate the spleen, preventing phlegm from forming and stopping coughing, clearing heat and detoxicating.Cure mainly: body void is weak; Nephrasthenia emission; Leukopenia; Hyperlipidemia; Virus hepatitis; Chronic gastroenteritis; Chronic bronchitis.

The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, clear away heart-fire relieving restlessness.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, and chest ventral spine pain, hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass lumps, and sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea pain, there is good effect." detailed outline " carries: the red sage root, and by " the sensible opinion of married woman " cloud, gynecopathy controlled by Siwu Tang, pays no attention to antenatal postpartum, how many through water, all can be general, and the only taste red sage root falls apart, and cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, and fall stillborn foetus, only metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

The seed of Oriental arborvitae is the kind benevolence of Cupressaceae plant arbor-vitae Biotaorientalis (L.) End1..Containing fat oil about 14%, mostly be unrighted acid composition, also containing a small amount of volatile oil, saponin, protein, calcium, phosphorus, iron multivitamin etc.The flat taste of the seed of Oriental arborvitae is sweet.Tool mental-tranquilization, the effect relaxed bowel.Control the diseases such as palpitation with fear, insomnia, seminal emission, night sweat, constipation." Japan hanako materia medica " carries " controls wind, profit skin." " medicineization justice " year " the saturating heart of seed of Oriental arborvitae fragrance, body profit taste blood." normal food has body building action.

Specific embodiment 1:

Annual spring plucks wilsonii tender leaf, first the free of contamination acanthopanax of anosis worm plucked is put into water and rinses, and after taking out, airing is on ventilative bamboo mat, and upset airing 7-12 hours, parches collection; The acanthopanax that airing is good is put into roller fixation device complete, complete 20-40 minute at 60-80 DEG C.Acanthopanax after just completing again dries in the shade after taking out naturally, puts into large iron pan and kneads, and kneads, firmly want evenly on first backward downwards, and when filament leaf bar rope is comparatively tight, baking machine turning in stir-fry 20-30 minute of putting into 50-60 DEG C when becoming dark brown is shaping.Naturally dried by the acanthopanax stir-fried, put into fragrance extracting machine Titian 20-30 minute, temperature controls in 50-60 DEG C, naturally dries after taking out.Then other bulk drugs are made granule or pulvis, mix the acanthopanax made, ultraviolet sterilization is packed.

Specific embodiment 2:

Annual spring plucks wilsonii tender leaf, first the free of contamination acanthopanax of anosis worm plucked is put into water and rinses, and after taking out, airing is on ventilative bamboo mat, and upset airing 7-12 hours, parches collection; The acanthopanax that airing is good is put into roller fixation device complete, complete 20-40 minute at 60-80 DEG C.Acanthopanax after just completing again dries in the shade after taking out naturally, puts into large iron pan and kneads, and kneads, firmly want evenly on first backward downwards, and when filament leaf bar rope is comparatively tight, baking machine turning in stir-fry 20-30 minute of putting into 50-60 DEG C when becoming dark brown is shaping.Naturally dried by the acanthopanax stir-fried, put into fragrance extracting machine Titian 20-30 minute, temperature controls in 50-60 DEG C, naturally dries, about 5000g after taking out.By all the other bulk drugs polygala root 1500g, Polygonum multiflower knotweed 1500g, dried rhizome of rehmannia 1500g, cape jasmine 1500g, fushen 1500g, mother-of-pearl 1500g, grass-leaved sweetflag 1500g, walnut 1500g, radix paeoniae rubrathe 1500g, matrimony vine 1500g, spina date seed 1500g, Flos Albiziae 1500g, bighead atractylodes rhizome 1500g, seed of Oriental arborvitae 1500g, mulberries 1500g, red sage root 1500g, RADIX POLYGONI MULTIFLORI PREPARATA 1500g, barrenwort 1500g, gynostemma pentaphylla 1500g, surplus stock medicine component is put into the ethanol accounting for its quality 10 times amount, heating and refluxing extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-110 order filters, be the ultrafiltration post ultrafiltration of 6000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use, the dregs of a decoction of the component bulk drug medicinal material crossed by above-mentioned alcohol extract again add the water heating and refluxing extraction 2 times accounting for its quality 10 times amount, remove supernatant, merge extract, 100-110 order filters, be the ultrafiltration post ultrafiltration of 6000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating be concentrated into paste, stand for standby use, extract medicinal extract by above-mentioned two kinds to merge, reducing pressure after reclaiming ethanol, it is concentrated to put into inspissator, by gained concentrate adjustment proportion to 1.40, reduce pressure to obtain medicinal extract, put into dryer to dry, then add honey or dextrin mediation, put into the granule that granulator makes 0.1-0.2 centimetre, mix the acanthopanax made, ultraviolet sterilization is packed.

Specific embodiment 3:

Annual spring plucks wilsonii tender leaf, first the free of contamination acanthopanax of anosis worm plucked is put into water and rinses, and after taking out, airing is on ventilative bamboo mat, and upset airing 7-12 hours, parches collection; The acanthopanax that airing is good is put into roller fixation device complete, complete 20-40 minute at 60-80 DEG C.Acanthopanax after just completing again dries in the shade after taking out naturally, puts into large iron pan and kneads, and kneads, firmly want evenly on first backward downwards, and when filament leaf bar rope is comparatively tight, baking machine turning in stir-fry 20-30 minute of putting into 50-60 DEG C when becoming dark brown is shaping.Naturally dried by the acanthopanax stir-fried, put into fragrance extracting machine Titian 20-30 minute, temperature controls in 50-60 DEG C, naturally dries, about 4500g after taking out.By all the other bulk drugs polygala root 1100g, Polygonum multiflower knotweed 1200g, dried rhizome of rehmannia 1100g, cape jasmine 1200g, fushen 1200g, mother-of-pearl 1200g, grass-leaved sweetflag 1200g, walnut 1200g, radix paeoniae rubrathe 1100g, matrimony vine 1200g, spina date seed 1200g, Flos Albiziae 1200g, bighead atractylodes rhizome 1200g, seed of Oriental arborvitae 1200g, mulberries 1200g, red sage root 1200g, RADIX POLYGONI MULTIFLORI PREPARATA 1100g, barrenwort 1200g, gynostemma pentaphylla 1100g, gets all the other bulk drug medicines and steeps in water, soaks more than 2 hours, add 8 times amount of bulk drug medicine gross weight respectively, the water extraction of 6 times amount gets 2 times, extraction time is 2 hours, 1 hour; Merge No. 2 extracts, extract is centrifugal by tubular type, obtains centrifugate, and centrifugate is crossed D 101 macroreticular resin and adsorbed, and first washes removal of impurities with water, then carries out wash-out with the ethanol of 70%, collects eluent, reduced pressure concentration, and one-tenth medicinal extract, for component becomes 1; The dregs of a decoction of bulk drug medicine said extracted crossed add ethanol, add respectively 10 times amount of dregs of a decoction gross weight, 8 times amount ethanol temperature leaching 2 times, the warm leaching time is 2 hours, 1.5 hours, and temperature is 85 DEG C, merges 2 warm immersion liquid; Temperature immersion liquid is evaporated to 1.25 medicinal extract when density is 60 DEG C, and medicinal extract is added the extraction into ethyl acetate secondary of its 4 times amount, extract has reclaimed ethyl acetate, becomes medicinal extract, obtains component 2; Above-mentioned two kinds of extraction components are merged, when reduced pressure concentration relative density is 80 DEG C 1.35 filtrate, reclaim ethanol, above-mentioned two kinds of extracts are inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.60, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, and be concentrated into every 1ml containing 0.1g crude drug amount, mix the fine powder sieved, mix the acanthopanax made, ultraviolet sterilization is packed.

Specific embodiment 4:

Annual spring plucks wilsonii tender leaf, first the free of contamination acanthopanax of anosis worm plucked is put into water and rinses, and after taking out, airing is on ventilative bamboo mat, and upset airing 7-12 hours, parches collection; The acanthopanax that airing is good is put into roller fixation device complete, complete 20-40 minute at 60-80 DEG C.Acanthopanax after just completing again dries in the shade after taking out naturally, puts into large iron pan and kneads, and kneads, firmly want evenly on first backward downwards, and when filament leaf bar rope is comparatively tight, baking machine turning in stir-fry 20-30 minute of putting into 50-60 DEG C when becoming dark brown is shaping.Naturally dried by the acanthopanax stir-fried, put into fragrance extracting machine Titian 20-30 minute, temperature controls in 50-60 DEG C, naturally dries, about 4200g after taking out.By all the other bulk drugs polygala root 1200g, Polygonum multiflower knotweed 1200g, dried rhizome of rehmannia 1100g, cape jasmine 1200g, fushen 1100g, mother-of-pearl 1100g, grass-leaved sweetflag 1200g, walnut 1100g, radix paeoniae rubrathe 1100g, matrimony vine 1200g, spina date seed 1200g, Flos Albiziae 1200g, bighead atractylodes rhizome 1200g, seed of Oriental arborvitae 1100g, mulberries 1200g, red sage root 1200g, RADIX POLYGONI MULTIFLORI PREPARATA 1200g, barrenwort 1100g, gynostemma pentaphylla 1100g, shredded 100 ~ 120 mesh sieves, after sieving, fine powder is for subsequent use, coarse granule puts into acid and alkali-resistance infusion kettle, at room temperature, 3 ~ 7 days are flooded together with more than 70 degree ethanol, then heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts are merged and leaves standstill, filter, filtrate is got after separation, by filtered through gauze, 50-60% ethanol is added in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge leaching liquor, be condensed into pasty state to insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the medicinal extract of 1.60, and the pasty state ointment after concentrated is dried to pulvis, then mix the acanthopanax made, ultraviolet sterilization packs.

Test example 1: acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: health protection tea of the present invention (preparing by implementation method 2).

Two, method:

1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, often organize 10, male and female half and half, dissolve suppository, are made into Cmax, by the administration of mouse maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mouse 20, each 10 of male and female.Suppository adding distil water is dissolved, is made into maximum concentration, by the maximal tolerance dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Test example 2: acute skin irritation test report of the present invention

1, experiment purpose: detect the present invention to the stimulation/corrosiveness of animal used as test skin and intensity

2, materials and methods:

2.1. tested material: health protection tea of the present invention (obtaining by embodiment method 2)

2.2. animal used as test: one grade of large ear white race rabbit, 10, female, body weight 2.1-2.3kg; Thered is provided by Affiliated Hospital of Qingdao University biology department Experimental Animal Center;

2.3. test method:

Its backbone both sides, back are cut by hair in test by the healthy rabbits selecting skin intact 10 for first 24 hours, the left and right each about 4cm × 4cm of unhairing area.Get tested material 0.2ml during test to be applied on two layers of gauze of 2.5cm × 2.5cm, be applied to skin of unhairing surface, side, oilpaper covers, immobilization with adhesive tape.Opposite side skin is as blank.Close after 4 hours, dismantle, and go residual tested material with warm water cleaning, within 1,24 and 48 hour after removing tested material, observe and smear position dermoreaction, and mark.

3, experimental result: any erythema does not appear in animal used as test skin, red and swollen, inflammation phenomenon.

4, brief summary: judge according to skin wound repair standards of grading in " disinfection technology standard " (1999), the present invention belongs to nonirritant to animal skin stimulus intensity.

Embodiment 3: long term toxicity test data

1, experimental technique

Random for cavy part is become 4 groups, often organizes 15.In guinea pig back backbone both sides, hair remover is evenly coated, make its scope about 40 square centimeters of losing hair or feathers.Clean hair remover, observe and often organize cavy after 24 hours and be coated with oral liquid solution 0.2,0.4 of the present invention and 0.8ml respectively, respectively containing crude drug 92,184 and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observe the ordinary circumstance of cavy, experiment terminates rear execution animal and carries out hematology, blood biochemical and pathological examination.

2, result

Above-mentioned three groups of medication cavy trunk unhairing districts, having no local skin has oedema, hyperemia, erythema, blutpunkte and ulcer.Medication group and control animals chroma of hair, ingest, the control group no significant difference such as four limbs are movable, blood biochemistry checking, medication group and control group are all in normal range (NR).Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathology.Prompting, Chinese medicinal healthcare tea long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.

Result of the test shows: experiment safety of the present invention.This medicine is 1: 150 to beta streptococcus, staphylococcus aureus, colibacillary MIC, gonococcus is 1: 150, Candida albicans is 1: 300, it is 5 minutes to the time of killing during 1: 20 dilution factor, be 10 minutes when 1: 50, being 20 minutes when 1: 100, is 40 minutes when 1: 200, is 8 hours when 1: 400.

Pharmacological experiment:

The present invention is the health protection tea of being made up of medicines such as wilsonii, polygala root, RADIX POLYGONI MULTIFLORI PREPARATA, barrenwort, the radix paeoniae rubrathe, has invigorating brain and relieving mental uneasiness, and production of sperm mends marrow, the effect of the nourishing qi and blood that clears liver and improve vision, for neurasthenia, insomnia, the disease such as forgetful, dizzy.Observe the present invention herein to monoamine neurotransmitter 5 one HT in underage mouse ability of learning and memory and brain, DA, NA, the impact of 5 one HIAA content.

1 test material

1.1 medicine health protection tea of the present invention, is prepared by the method for embodiment 2 by Pharmacy of the court; Positive control drug, revises Qiyeshen' and tablet, the accurate word Z20093724 of traditional Chinese medicines, revises Group Plc and produces.

1.2 animal Kunming mouse 11 ~ 15g, male and female half and half, purchased from Changchun Biological Products Institute, credit number: SCXK.2002.0001.

1.3 instrument Y. type water mazes; ES.180 electronic analytical balance, Shenyang Long Teng company produces; RF.540 type sepectrophotofluorometer, Japanese Shimadzu Corporation produces.

1.4 reagent 5. hydroxytryptamine creatinine sulfates, China Drug Co.'s Solution on Chemical Reagents in Shanghai purchasing and supply station, lot number: 65-02.28, Switzerland's import packing, purity 99%; 5. hydroxyindole acetic acid, Sigma product, lot number: 60k1083, purity 98% ~ 100%; Potassium bitartrate norepinephrine, Shanghai Hefeng Pharmaceutical Co., Ltd. produces, lot number: 0205037,2mg/mL; Dopamine hydrochloride, is produced by Shanghai Hefeng Pharmaceutical Co., Ltd., lot number: 0204011,20mg/2mL; It is pure that other reagent is domestic analysis.

2 methods and result

Mouse 80 is got on the impact (water maze) of underage mouse ability of learning and memory, is divided at random: blank group, Qiyeshen' and tablet 4mL/kg administration group, of the present invention group of 10.0,5.0,2.5mL/kg 3 dosed administration groups.Administration every day 1 time, in the 11d of first administration, successive administration 15d, starts that mouse is placed in water maze and trains.Experiment adopts Y. type water labyrinth apparatus.This device divides long arm end and two branch galianconism ends.Left side galianconism end is equipped with platform, stays in part, have lighting above platform as mouse.Three branch arm ends leave the opening of a 10cm, and mid portion black acrylic covers, as secret tunnel.Depth of water 10cm, water temperature (30 ± 2) DEG C, train 5d altogether, every animal trains 10 times every day, during training, the afterbody of mouse is put into water lightly towards two forks in labyrinth, directly reaching in 15S with it has the platform of light source for correct response, otherwise is considered as mistake, record the number of times that every animal is made a mistake every day, and calculate 5d average achievement.Experimental data represents with-X ± S, compares by the sample 2.1 mean t method of inspection, the results are shown in Table 1 between group.

Table 1 the present invention is on the impact (x ± s, n=16) of underage mouse ability of learning and memory

Note: with blank group than * P<0.05, * * P<0.01, * * * P<0.001, following table all with.

From table 1 result, 10.0mL/kg dosage group of the present invention, starts the errors number that just can reduce mouse significantly in the 3d of training, and along with the prolongation of administration time, errors number reduces gradually, illustrates that it can strengthen ability of learning and memory in mice.

2.2 impacts on monoamine transmitter contents in underage mouse brain

Get mouse 80, the same grouping administration, successive administration 15d, after last administration, 1h is by sacrifice of animal, gets brain tissue rapidly, puts into liquid nitrogen immediately and fills with freezing, take out homogenate in batches, by 5-HT, DA, NA in fluorescence spectrophotometry Mice brain tissues, the content of 5-HIAA, experimental data represents with x ± s, compares by the sample average t method of inspection, the results are shown in Table 2 between group.

Table 2 the present invention is on the impact (x ± s, n=16) of monoamine transmitter contents in underage mouse brain

From table 2 result, the present invention can increase 5-HT, DA, NA content in mouse brain tissue significantly.

2.3 get mouse 80 to the impact of underage mouse thymus gland, spleen, Weight-index, with 2.1 grouping administrations, after last administration, 1h is by sacrifice of animal, get thymus gland, spleen, adrenal gland weigh calculating organ index, experimental data represents with x ± s, compare between group by the sample average t method of inspection, the results are shown in Table 3.

Table 3 the present invention is correlated with on underage mouse the impact (x ± s, n=16) of organ index

From table 3 result, the present invention can increase Weight-index significantly.

3 discuss

Learning and memory is one of Premium Features of brain, is the important indicator weighing animal intelligence development, and learning and memory is realized by a series of physiological and biochemical procedure of nervous system.Monoamine neurotransmitter is to notice, and memory and respond have important regulating action, and it comprises NA, DA, 5-HT, 5-HIAA etc., NA, DA, 5-HT rich content in cynapse, and it not only transmits relevant with cynapse, and relevant with cynapse maturation.The minimizing of NA, DA, 5-HT, 5-HIAA, must affect the balance of neurotransmitter in brain, cause intellectual damage and go down.Experimental result shows, Anshen Bunao mixture can strengthen the ability of learning and memory of underage mouse, also show that it can improve NA in animal brain simultaneously, DA, the content of 5-HT, Anshen Bunao mixture has been applied for many years on I narrow-necked earthen jar bed, effect obviously, determined curative effect, but be used for the treatment of forgetful mechanism of action to it and never carry out deep research, point out herein from the result that affects of monoamine neurotransmitter aspect in immature animal brain, the present invention can by activating brain metabolism, increase multiple neurohumoral quantity in cerebral cortex, thus reach the function strengthening memory.Experimental result also shows the present invention can increase underage mouse adrenal gland weight, and administration group and control group have notable difference, and this also may be relevant containing the kidney-reinforcing drug such as wilsonii, barrenwort with its side.Modern medicine research proves that the action character of wilsonii is substantially identical with ginseng, has and regulates body disorderly, make it to be tending towards normal function.Have good raising immunity, comparatively ginseng is remarkable, and significantly can improve hypoxia-bearing capability.Bowl spares, benefit essence, strong will, wines used as antirheumatic, strengthen the bone, blood circulation and promoting silt, the function such as stomach invigorating diuresis.Clothes of a specified duration " are made light of one's life by commiting suicide and are endured hardships ".Wilsonii contains noticeable composition---and eleutheroside, it can stimulate mind & body vigor.Numerous scientific publications about wilsonii has demonstrated it and has improved immunity, strengthens endurance and ability, increases alert and resourceful and learning ability.Numerous usage obtains confirmation all in human experimentation.Wilsonii is rehabilitation after being ill, bears too much pressure or anxiety, works excessive, chronic disease cause weakly crowd and those need to reach very welcome self-medication medicine in the people on physiology and psychological performance peak.It has support immune system to have the report of considerable quantity to point out, recovers improper low blood pressure, improves the circulatory system, makes disorderly glycolipid metabolism normalization, liver, testis, anabolic effect of bone density and other vitals.

Radix Acanthopanacis senticosi tea is containing multiple glucoside, wherein part glucoside and panaxoside have similar physiologically active, there is raising immunity (the raising immunity of eleutheroside is also stronger than ginseng), add essence benefit marrow and anti-ageing, soothing nerves and assisting sleep dormancy effect of fostering the spirit of nobility, being the useful health drink of drink, is the first-class natural beverage of the elderly and presenting friends.Effect of radix Acanthopanacis senticosi tea in ancient times just known by people, effect that " Mingyi Bielu " describes wilsonii to be had " bowl spares benefit essence, hard muscles and bones, strong will ".Therefore ancients have saying of " Ning get Yi, slender acanthopanax, not wanting the full car of gold and jade "; Wilsonii sees Shennong's Herbal, is classified as top grade; Top grade is refer to nontoxic, and for a long time clothes can be made light of one's life by commiting suicide, to be promoted longevity and harmless.Therefore radix Acanthopanacis senticosi tea also can as daily drink, can Long-Time Service.

Specific embodiment: seal certain, man, 18 years old.To play basketball brain of wounding, minor concussion.Consciousness lost at that time, and after recovery, patient often has headache, felt sick, and vomiting is dizzy, and photophobia and the symptom such as weak, meanwhile, have obvious ecmnesia (retrograde amnesia) phenomenon, namely can not recall the process of injured front and back.Often there is giddy, headache, feel sick, vomiting, tinnitus, the symptoms such as insomnia.Diagnosis tongue is red, the thin Huang of tongue, thready rapid pulse.Card belongs to hyperactivity of heart-liver fire, deficiency of YIN-blood.Control the suitable flat proheparin heart, tranquilizing the mind.Fang Yong: wilsonii 25g, polygala root 12g, Polygonum multiflower knotweed 13g, dried rhizome of rehmannia 12g, cape jasmine 11g, fushen 12g, mother-of-pearl 13g, grass-leaved sweetflag 12g, walnut 12g, radix paeoniae rubrathe 13g, matrimony vine 12g, spina date seed 12g, Flos Albiziae 13g, bighead atractylodes rhizome 12g, seed of Oriental arborvitae 13g, mulberries 13g, red sage root 12g, RADIX POLYGONI MULTIFLORI PREPARATA 11g, barrenwort 11g, gynostemma pentaphylla 12g.Make health protection tea, every day works as tea-drinking, serve on 15 days.Further consultation, tells and takes rear headache, feels sick, and vomiting, dizzy, photophobia and weak phenomenon obviously alleviate, and can fall asleep to daybreak, brain is also no longer given free rein to fancy, and almost no longer has a sleepless night.After front enters 30 days again, all diseases are all flat, sleep stable, do not recur always.

Claims

1. the acanthopanax root health tea of an Anshen Bunao, it is characterized in that, described acanthopanax root health tea comprises the bulk drug of following parts by weight: wilsonii 10 ~ 50 parts, polygala root 10 ~ 20 parts, Polygonum multiflower knotweed 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, cape jasmine 10 ~ 20 parts, fushen 10 ~ 20 parts, mother-of-pearl 10 ~ 20 parts, grass-leaved sweetflag 10 ~ 20 parts, walnut 10 ~ 20 parts, the radix paeoniae rubrathe 10 ~ 20 parts, matrimony vine 10 ~ 20 parts, spina date seed 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, the seed of Oriental arborvitae 10 ~ 20 parts, mulberries 10 ~ 20 parts, the red sage root 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, barrenwort 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts.

2. the acanthopanax root health tea of Anshen Bunao according to claim 1, it is characterized in that, described acanthopanax root health tea comprises the bulk drug of following parts by weight: wilsonii 10 ~ 30 parts, polygala root 10 ~ 15 parts, Polygonum multiflower knotweed 10 ~ 15 parts, cape jasmine 10 ~ 15 parts, cape jasmine 10 ~ 15 parts, fushen 10 ~ 15 parts, mother-of-pearl 10 ~ 15 parts, grass-leaved sweetflag 10 ~ 15 parts, walnut 10 ~ 15 parts, the radix paeoniae rubrathe 10 ~ 15 parts, matrimony vine 10 ~ 20 parts, spina date seed 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, the seed of Oriental arborvitae 10 ~ 20 parts, mulberries 10 ~ 20 parts, the red sage root 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, barrenwort 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts.

3. the acanthopanax root health tea of Anshen Bunao according to claim 1, it is characterized in that, described acanthopanax root health tea comprises the bulk drug of following parts by weight: wilsonii 10 ~ 40 parts, polygala root 10 ~ 20 parts, Polygonum multiflower knotweed 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, cape jasmine 10 ~ 20 parts, fushen 10 ~ 20 parts, mother-of-pearl 10 ~ 20 parts, grass-leaved sweetflag 10 ~ 20 parts, walnut 10 ~ 20 parts, the radix paeoniae rubrathe 10 ~ 20 parts, matrimony vine 10 ~ 15 parts, spina date seed 10 ~ 15 parts, Flos Albiziae 10 ~ 15 parts, the bighead atractylodes rhizome 10 ~ 15 parts, the seed of Oriental arborvitae 10 ~ 15 parts, mulberries 10 ~ 15 parts, the red sage root 10 ~ 15 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 15 parts, barrenwort 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 15 parts.

4. the preparation method of the acanthopanax root health tea of Anshen Bunao as described in any one of claims 1 to 3 item, it is characterized in that, the preparation process of described acanthopanax root health tea comprises following aspect:

C. shaping acanthopanax is put into and is carried camera Titian;

D. all the other bulk drugs described are prepared into granule or pulvis,

5. the preparation method of the acanthopanax root health tea of Anshen Bunao according to claim 4, it is characterized in that, in described step a, annual spring plucks wilsonii tender leaf, first the free of contamination acanthopanax of anosis worm plucked is put into water to rinse, after taking out, airing is on ventilative bamboo mat, and upset airing 7-12 hours, parches collection; The acanthopanax that airing is good is put into roller fixation device complete, complete 20-30 minute at 70-80 DEG C.

6. the preparation method of the acanthopanax root health tea of Anshen Bunao according to claim 4, it is characterized in that, in described step b, acanthopanax taking-up after completing is dried in the shade afterwards naturally, put into large iron pan to knead, knead on first backward downwards, firmly want evenly, when filament leaf bar rope is comparatively tight, the baking machine turning in putting into 50-60 DEG C when becoming dark brown fry 20-30 minute shaping.

7. the preparation method of the acanthopanax root health tea of Anshen Bunao according to claim 4, is characterized in that, in described step c, the acanthopanax stir-fried is dried naturally, put into fragrance extracting machine Titian 20-30 minute, temperature controls in 50-60 DEG C, naturally dries after taking out.

8. the preparation method of the acanthopanax root health tea of Anshen Bunao according to claim 4, it is characterized in that, in described steps d, the preparation method making granule when all the other bulk drugs is: surplus stock medicine component is put into the ethanol accounting for its quality 10 times amount, heating and refluxing extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-110 order filters, then is the ultrafiltration post ultrafiltration of 6000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use; The dregs of a decoction of the component bulk drug medicinal material crossed by above-mentioned alcohol extract again add the water heating and refluxing extraction 2 times accounting for its quality 10 times amount, remove supernatant, merge extract, 100-110 order filters, be the ultrafiltration post ultrafiltration of 6000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating be concentrated into paste, stand for standby use; Extract medicinal extract by above-mentioned two kinds to merge, reducing pressure after reclaiming ethanol, it is concentrated to put into inspissator, by gained concentrate adjustment proportion to 1.40; reduce pressure to obtain medicinal extract; put into dryer to dry, then add honey or dextrin mediation, put into the granule that granulator makes 0.1-0.2 centimetre.

9. the preparation method of the acanthopanax root health tea of Anshen Bunao according to claim 4, it is characterized in that, in described steps d, the preparation method making pulvis when all the other bulk drugs is: get all the other bulk drugs and steep in water, soak more than 2 hours, add 8 times amount of bulk drug medicine gross weight respectively, the water extraction of 6 times amount gets 2 times, extraction time is 2 hours, 1 hour; Merge No. 2 extracts, extract is centrifugal by tubular type, obtains centrifugate, and centrifugate is crossed D 101 macroreticular resin and adsorbed, and first washes removal of impurities with water, then carries out wash-out with the ethanol of 70%, collects eluent, reduced pressure concentration, and one-tenth medicinal extract, for component becomes 1; The dregs of a decoction of bulk drug medicine said extracted crossed add ethanol, add respectively 10 times amount of dregs of a decoction gross weight, 8 times amount ethanol temperature leaching 2 times, the warm leaching time is 2 hours, 1.5 hours, and temperature is 85 DEG C, merges 2 warm immersion liquid; Temperature immersion liquid is evaporated to 1.25 medicinal extract when density is 60 DEG C, and medicinal extract is added the extraction into ethyl acetate secondary of its 4 times amount, extract has reclaimed ethyl acetate, becomes medicinal extract, obtains component 2; Above-mentioned two kinds of extraction components are merged, when reduced pressure concentration relative density is 80 DEG C 1.35 filtrate, reclaim ethanol, above-mentioned two kinds of extracts are inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.60, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, mixes the fine powder sieved.

10. the preparation method of the acanthopanax root health tea of Anshen Bunao according to claim 4, is characterized in that, in described step e, will obtain granule in steps d or pulvis mixes with the acanthopanax that above-mentioned steps makes, after ultraviolet sterilization, pack packaging is shaping.