CN103054073A

CN103054073A - Beautifying fish scale jelly and preparation method thereof

Info

Publication number: CN103054073A
Application number: CN2012105915262A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Huaren Information Technology Development Co Ltd
Current assignee: Guangzhou Lushi Food Co ltd
Priority date: 2012-12-29
Filing date: 2012-12-29
Publication date: 2013-04-24
Anticipated expiration: 2032-12-29
Also published as: CN103054073B

Abstract

The invention provides a beautifying fish scale jelly. Raw materials of the beautifying fish scale jelly comprise one or more of scales, peppers, green Chinese onions, gingers, aniseeds, myrcia, cinnamons, adenophora stricta, salt, cooking wine, a traditional Chinese medicine additive and water. Raw material medicines of the traditional Chinese medicine additive of the fish scale jelly comprise motherwort, radix polygoni multiflori praeparata, bighead atractylodes rhizome, Chinese-dates, rhizoma bletillae, glossy privet fruits, Chinese trumpet creeper, radix paeoniae alba, rhizoma bletillae, astragalus mongholicus, peach blossom, poria cocos, caulis spatholobi, codonopsis pilosula, nacre mother of pearl, angelica sinensis, albizia flower, peach kernels, rhizoma cyperi, radix angelicae, the root of red-rooted salvia, dogwoods, semen coicis and rhizoma dioscoreae. According to the invention, collagens can be supplemented and nutritions can be increased; the mouthfeel is distinctive; as traditional Chinese medicines for promoting circulation and removing stasis are added, the medicines are fresh in mouth feel and cannot affect smells of the fish scale jelly; the beautifying fish scale jelly provided by the invention has the effects of making skins soft and smooth, removing wrinkles, supplementing lost collagens, promoting circulation and removing stasis after being used for a long time; and moreover, the beautifying fish scale jelly provided by the invention has the advantages of simple and easily-obtained raw materials and simple production method and is especially suitable for people loving beauty to use.

Description

A kind of beauty treatment fish scale jelly and preparation method thereof

Technical field

The present invention relates to contain the food that derives from animal, plant composition, particularly a kind of beauty treatment fish scale jelly and preparation method thereof.

Background technology

Fish scale usually all scrapes off it when refuse and throws away.In fact, fish scale contains rich in protein, fat and multivitamin, also has the trace element of iron, zinc, calcium and multiple needed by human, and colloid.Also contain multiple unrighted acid in the fish scale, can reduce cholesterol gathering on vascular wall, have the effects such as prevention of arterial sclerosis, hypertension and heart disease.Along with the day by day raising of living standard, people are more and more higher to the requirement of diet, and so-called it is difficult to cater for all tastes, and taste is more and more unique.Eat healthyly, the exquisiteness of eating has become mainstream of society thought gradually.How on the basis of not destroying the nutritive value of food materials own, can develop innovation again, to improve mouthfeel and unique flavor, adapt to individual character and select to have become the huge challenge that food service industry faces.Food no longer is that full abdomen is the primary, collect health-preserving, beauty treatment, multi-functional being integrated of reducing weight, the growth requirement of the more and more higher society that just can meet the demands.

The nutritionist studies discovery, and fish scale is special health food.It contains more lecithin, has to strengthen memory, slow effect of prolonging cell ageing.Fish phosphorus contains rich in protein, fat and multivitamin, also has the micronutrient of iron, zinc, calcium and multiple needed by human, and wherein the content of calcium, phosphorus is very high, can preventing child rickets and middle-aged and old osteoporosis and fracture.Brainstrust is found, contained multiple unrighted acid in the fish scale, can in blood, help to transmit and chyle fat with protein-bonded form, reduce cholesterol and deposit at vascular wall, have the multiple effects such as the artery sclerosis of preventing, preventing hypertension and heart disease.

Fish scale is the sclerotin that the collagen of fish skin corium generates, and formal name used at school is ichthylepidin, and it demonstrates effect out of the ordinary at medical domain.The 6-that extracts from fish scale dredges for guanine, the clinical treatment acute leukemia, and efficient is 70%～75%; And cancer of the stomach, lymphadenoma also there is special effect.Contain a large amount of collagens in the fish scale.Collagen is a beauty treatment much-talked-about topic that often appears at now in people's mouth, from cosmetics for external use, to oral liquid, capsule, can say, can both see its shadow everywhere.Collagen also claims ossein, is a kind of thread collagen fabric, and its major physiological function is to do the adhesion substance of connective tissue, can make the solid high resilience of skin, and it is present in the positions such as human body skin, bone, tendon.

Concerning skin, it and elastic fibers make a concerted effort to consist of the mesh-supported body, for skin corium provides stable strong support.With advancing age, the collagen content in the human body can reduce gradually, and the mesh-supported body will lose original elasticity gradually, and when elasticity and the reduction of moisturizing degree of skin corium, the stereotype phenomenons such as wrinkle, color spot will appear in skin.Skin is comprised of epidermis, corium, subcutaneous fat etc., and the body of skin is corium, and collagen accounts for more than 70% of protein content content in the dermal cell.It is two large crucial that the health of skin has---and crease-resistant and moisturizing, collagen make cell become plentiful, complete, keep skin elasticity and moistening, effectively prevent from wearing out.Fish scale collagen and other collagen ratios, its protein easily decomposes, easily digested, absorption.It is apparent in view that people take rear effect, can increase the amino acid in the blood, can promote again collagen to generate simultaneously.

Summary of the invention

Technical problem to be solved by this invention is, as the waste material of daily life, contains a large amount of collagens in the fish scale.Collagen is often to appear at now cosmetic good merchantable brand in people's mouth.Fish scale is the sclerotin that the collagen of fish skin corium generates, and formal name used at school is ichthylepidin, and it demonstrates effect out of the ordinary at medical domain.How turning waste into wealth, making the maximum performance of fish scale skin makeup effect is emphasis of the present invention.The present invention chooses and all belongs to the dirty product of heat-clearing profit, does not destroy the mouthfeel of fish scale jelly.The present invention have nti-freckle crease-resistant, the profit in vain the effect.Being applicable to skin colour calmness, wrinkle, to increase the women edible.Usefulness can make the skin delicacy lubricious for a long time, removes wrinkle, replenishes the collagen that runs off, and good efficacy promoting blood circulation and removing blood stasis is more arranged.

For solving the problems of the technologies described above, the invention provides a kind of beauty treatment fish scale jelly, comprise in the following raw material one or more: fish scale, Chinese prickly ash, shallot, ginger, aniseed, spiceleaf, cassia bark, the root of straight ladybell, salt, cooking wine, Chinese medicine additive, water.

Described Chinese medicine additive can comprise the bulk drug of following parts by weight: 10～20 parts of motherworts, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts in date, 10～20 parts of the fruit of glossy privets, 10～20 parts of Chinese trumpet creepers, 10～20 parts of the root of herbaceous peonys, 10～20 parts of bletillas, 10～20 parts of the Radixs Astragali, 10～20 parts in peach blossom, 10～20 parts in Poria cocos, 10～20 parts of reticulate millettias, 10～20 parts of Radix Codonopsis, 10～20 parts of mother-of-pearls, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Flos Albiziaes, 10～20 parts in peach kernel, 10～20 parts of rhizoma cyperis, 10～20 parts of the roots of Dahurain angelica, 10～20 parts of the reds sage root, 10～20 parts of Fructus Cornis, 10～20 parts of coix seeds, 10～20 parts of Chinese yams.

Described Chinese medicine additive can comprise the bulk drug of following parts by weight: 10～15 parts of motherworts, 10～15 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～15 parts of the bighead atractylodes rhizomes, 10～15 parts in date, 10～15 parts of the fruit of glossy privets, 10～15 parts of Chinese trumpet creepers, 10～15 parts of the root of herbaceous peonys, 10～15 parts of bletillas, 10～15 parts of the Radixs Astragali, 10～15 parts in peach blossom, 10～20 parts in Poria cocos, 10～20 parts of reticulate millettias, 10～20 parts of Radix Codonopsis, 10～20 parts of mother-of-pearls, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Flos Albiziaes, 10～20 parts in peach kernel, 10～20 parts of rhizoma cyperis, 10～20 parts of the roots of Dahurain angelica, 10～20 parts of the reds sage root, 10～20 parts of Fructus Cornis, 10～20 parts of coix seeds, 10～20 parts of Chinese yams.

Described Chinese medicine additive can comprise the bulk drug of following parts by weight: 10～20 parts of motherworts, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts in date, 10～20 parts of the fruit of glossy privets, 10～20 parts of Chinese trumpet creepers, 10～20 parts of the root of herbaceous peonys, 10～20 parts of bletillas, 10～20 parts of the Radixs Astragali, 10～20 parts in peach blossom, 10～15 parts in Poria cocos, 10～15 parts of reticulate millettias, 10～15 parts of Radix Codonopsis, 10～15 parts of mother-of-pearls, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Flos Albiziaes, 10～15 parts in peach kernel, 10～15 parts of rhizoma cyperis, 10～15 parts of the roots of Dahurain angelica, 10～15 parts of the reds sage root, 10～15 parts of Fructus Cornis, 10～15 parts of coix seeds, 10～15 parts of Chinese yams.

Described beauty treatment fish scale jelly, preferably include the raw material of following weight portion: 300 ~ 500 parts on fish scale, 3 ~ 6 parts in Chinese prickly ash, 3 ~ 6 parts in shallot, 3 ~ 6 parts in ginger, 3 ~ 6 parts of aniseed, 3 ~ 6 parts of spiceleafs, 3 ~ 6 parts on cassia bark, 3 ~ 6 parts of the root of straight ladybell, 10 ~ 20 parts of salt, 10 ~ 20 parts of cooking wine, 20 ~ 40 parts of Chinese medicine additives, 300 ~ 1000 parts in water.

For solving the problems of the technologies described above, the present invention also provides the Chinese medicine additive that uses in a kind of as mentioned above beauty treatment fish scale jelly.

For solving the problems of the technologies described above, the present invention provides again a kind of preparation method of described Chinese medicine additive, and described Chinese medicine additive formulation is granule, and its preparation process is:

A. described bulk drug is put into the pulverizer grinding and sieving,

B. the rear remaining particle that will sieve is put into the ethanol heating and refluxing extraction 2 times;

C. get again the dregs of a decoction behind the above-mentioned alcohol extract, add the water heating and refluxing extraction 2 times;

D. above-mentioned two kinds of extracts are merged, decompression recycling ethanol and spray-drying get medicinal powder; The fine powder that mixing sieves obtains adds dextrin and granulates.

Among the described step a, described bulk drug is put into pulverizer pulverize the rear 120 order dusting covers of crossing, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves for subsequent use; Among the described step b, the rear remaining particle that sieves is put into the ethanol heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts merging are left standstill; Among the described step c, the dregs of a decoction that above-mentioned alcohol extract is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts merging are left standstill.

In the described steps d above-mentioned two kinds of extracts are merged, 1.38 filtrate when the reduced pressure concentration relative density is 70 ℃, Recycled ethanol is adjusted proportion to 1.06 with gained filtrate, pass into spray dryer and carry out spray-drying, the compressed air pressure of crossing the spray dryer shower nozzle is 4kg/m ², the hothouse hot stream temperature is 100 ℃, gets raw material medicinal powder; The raw material fine powder that obtains after sieving mixed with raw material medicinal powder add dextrin and granulate.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of described beauty treatment fish scale jelly, preparation process is: the fish scale that scrapes, put after cleaning up and add 1 ~ 2 times of water gaging of weight portion in the pot, used coddle after boiling instead 1 hour, boil that fish scale bleaches, curling so that soup in the pasty state, then pull fishing squama residue out; Put into the Chinese prickly ash that is contained in seasoner vessel, shallot, ginger, aniseed, spiceleaf, cassia bark, the root of straight ladybell, then with salt, cooking wine; After again boiling, add Chinese medicine additive and mix thoroughly, endure half an hour, pour container into, after the cooling, jelly.

Chinese medicine fish scale jelly unique flavor provided by the invention, mouthfeel is good, has the double action of the property of medicine and trophism concurrently, both can replenish the increase collagen, can have additional nutrients again; Mouthfeel is unique; Add some Chinese medicines promoting blood circulation and removing blood stasis, the most mouthfeel of these medicinal materials is light, does not affect the taste of fish scale jelly, makes the people be easy to accept, and more can reach preferably skin-care and beautifying, replenishing collagen, the effect of removal color spot.And tasty, unique flavor; Side effect without any food security.Adopt brand-new Chinese medicine additive, reach the requirement of pollution-free food pure natural, can obtain good economic benefit.The human body holistic health is fundamentally protected and coordinated to Chinese herb feed additive.The present invention chooses and all belongs to the dirty product of heat-clearing profit, does not destroy the mouthfeel of fish scale jelly.The present invention have nti-freckle crease-resistant, the profit in vain the effect.Being applicable to skin colour calmness, wrinkle, to increase the women edible.For a long time usefulness can make the skin delicacy lubricious, removes wrinkle, replenishes the collagen that runs off, and good efficacy promoting blood circulation and removing blood stasis is more arranged, and raw material is simple and easy to, and production method is simple, be particularly suitable for the vast personage of liking to be beautiful and use.

The specific embodiment

Fish have a large amount of fish to make delicacies and allow people taste as the cuisines on the dining table every day.But fish scale is lost as discarded object always, and fish scale contains rich in protein, fat and multivitamin in fact, also has the trace element of iron, zinc, calcium and multiple needed by human, and colloid.Also contain multiple unrighted acid in the fish scale, can reduce cholesterol gathering on vascular wall, have the effects such as prevention of arterial sclerosis, hypertension and heart disease.

The present invention has the collagen that replenish to run off, good efficacy promoting blood circulation and removing blood stasis is more arranged, and raw material is simple and easy to.

The specific embodiment 1: get the 500g fish scale, make the fish scale gelation, water will add less, and institute's water consumption is 800g, uses coddle after boiling instead 1 hour, boil that fish scale bleaches, curling so that soup in the pasty state, then pull fishing squama residue out; Put into the Chinese prickly ash 4g that is contained in seasoner vessel, shallot 3g, ginger 5g, aniseed 4g, spiceleaf 3g, then cassia bark 5g, the root of straight ladybell 4g add an amount of salt 10g, cooking wine 10g; After again boiling, add Chinese medicine additive 30g and mix thoroughly, boil half an hour with little fire, pour container into, after the cooling, jelly.Do fish scale jelly then water to add a little lessly, add green onion, the garlic of a little choppings after being boiled into, after again boiling, monosodium glutamate is mixed thoroughly slightly, pours container into, after the cooling, jelly.If add a little sesame oil and peanut butter before the food, local flavor is better.

The specific embodiment 2: get the 1000g fish scale, make the fish scale gelation, water will add less, and institute's water consumption is 1500g, uses coddle after boiling instead 1 hour, boil that fish scale bleaches, curling so that soup in the pasty state, then pull fishing squama residue out; Put into the Chinese prickly ash 8g that is contained in seasoner vessel, shallot 6g, ginger 7g, aniseed 7g, spiceleaf 8g, then cassia bark 9g, the root of straight ladybell 6g add an amount of salt 25g, cooking wine 25g; After again boiling, add Chinese medicine additive 50g and mix thoroughly, boil half an hour with little fire, pour container into, after the cooling, jelly.

China's Chinese herbal medicine resource vast in territory divides abundant, aspect the development Chinese herb feed additive huge potentiality are being arranged, a large amount of production practices and scientific research have confirmed that also Chinese herbal medicine has many nutritional labelings and bioactivator, such as alkaloid, polysaccharide, volatile oil, boots matter, organic acid etc., have the double action of the property of medicine and trophism concurrently, both preventable disease can improve immunity again; Direct bactericidal not only, and can regulate the immunity function of body, have non-specific antibacterial action.Therefore abandon the chemical classes additive, use the relieved Chinese medicine additive of safety, making food reach the delicious effect of safety is our consistent pursuit; The more important thing is, the advantage of Chinese herb feed additive uniqueness is to have pure natural property, from nature animal, plant and mineral matter, and its natural structure and activity have been kept, the long-term use and drug residue free, without the resistance to the action of a drug with have no side effect, be good Green medicament additive, also catered to the pursuit of consumers in general to the product of green non-pollution no drug residue, in food production, seem more meaningful so do additive with Chinese herbal medicine.

Analyze the effect that Chinese herbal feed additive roughly has following several respects from theory of traditional Chinese medical science: namely regulating the flow of vital energy helps digestion, helps the spleen stomach invigorating, has conditioning and dredges that muscle is invigorated blood circulation, the effect of food digesting stomach fortifying strengthening spleen and nourishing stomach, such as the bighead atractylodes rhizome; Invigorating blood circulation addiction, vigorous circulation, enhance metabolism, have regulate channels and activate collateral, loose skin invigorates blood circulation, vigorous blood circulation, the effect such as enhance metabolism is such as Radix Angelicae Sinensis, date and coix seed; Tonifying Qi establishing-Yang, nourishing the blood and yin have the qi-restoratives righting, regulate yin and yang imbalance, strengthen the effect of body antimicrbial power, such as the Radix Astragali etc.; Heat reliving and toxin-eliminating, bactericidal effect, by clear up interior heat, removing toxicity for detumescence, the subcutaneous ulcer that disappears dissipating bind and inhibition or kill bacteria such as honeysuckle; Calm the nerves arresting convulsion, the promoting the circulation of qi of having one's ideas straightened out can tranquilizing and allaying excitements, a surname opens up the effect of key, such as the seed of Oriental arborvitae.

The immunologic function that has the adjusting body from the modern pharmacology Epidemiological Analysis take Chinese herbal medicine effective ingredients as the additive of main body, and non-specific antibacterial action, Chinese herbal medicine contains the bioactivators such as alkaloid, polysaccharide, two class volatile oil, organic acid flavones and bioflavonoid of anti-antibacterial composition, to regulating human body immune function, the good effect of improving health conditions.It is reported, ward off to have more and promote the thymus gland reaction, stimulate reticuloendothelial cell to improve the specific antigen respond; Alkaloid can strengthen the phagocytic function of body fluid and cellular immune function and stimulating expression of macrophage, two classes can strengthen the phagocytic function of reticuloendothelial system, and but enhancing antibody generates, the value that promotes antigen-antibody reaction and lymphocyte transformation organic acid can regulate in the intestines prevents the breeding of harmful bacteria and the activity of raising enzyme, and the body intracellular metabolic can normally be carried out.Divide compromise herbal medicine feed addictive not only to contain the nutriment of some from the theory of modern nutriology, but also contain unknown growth regulator and the pigment of some, has the biochemical reaction that activates directly or indirectly body, strengthen the biosynthesis effect, thereby promote the production performance of human body.

Specific embodiment 3: get motherwort 100g, RADIX POLYGONI MULTIFLORI PREPARATA 100g, bighead atractylodes rhizome 100g, date 100g, fruit of glossy privet 100g, Chinese trumpet creeper 100g, root of herbaceous peony 100g, bletilla 100g, Radix Astragali 100g, peach blossom 100g, Poria cocos 100g, reticulate millettia 100g, Radix Codonopsis 100g, mother-of-pearl 100g, Radix Angelicae Sinensis 100g, Flos Albiziae 100g, peach kernel 100g, rhizoma cyperi 100g, root of Dahurain angelica 100g, red sage root 100g, Fructus Corni 100g, coix seed 100g, Chinese yam 100g.Described bulk drug is put into pulverizer pulverize the rear 120 order dusting covers of crossing, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves for subsequent use; The rear remaining particle that sieves is put into the ethanol heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts merging are left standstill; Among the described step c, the dregs of a decoction that above-mentioned alcohol extract is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts merging are left standstill.Above-mentioned two kinds of extracts are merged, 1.38 filtrate when the reduced pressure concentration relative density is 70 ℃, Recycled ethanol is adjusted proportion to 1.06 with gained filtrate, passes into spray dryer and carries out spray-drying, and the compressed air pressure of crossing the spray dryer shower nozzle is 4kg/m ², the hothouse hot stream temperature is 100 ℃, gets raw material medicinal powder; The raw material fine powder that obtains after sieving mixed with raw material medicinal powder add dextrin and put into granulator and make 0.25mm～0.40mm granule.

Specific embodiment 4: get motherwort 100g, RADIX POLYGONI MULTIFLORI PREPARATA 100g, bighead atractylodes rhizome 100g, date 100g, fruit of glossy privet 100g, Chinese trumpet creeper 100g, root of herbaceous peony 100g, bletilla 100g, Radix Astragali 100g, peach blossom 100g, Poria cocos 100g, reticulate millettia 100g, Radix Codonopsis 100g, mother-of-pearl 100g, Radix Angelicae Sinensis 100g, Flos Albiziae 100g, peach kernel 100g, rhizoma cyperi 100g, root of Dahurain angelica 100g, red sage root 100g, Fructus Corni 100g, coix seed 100g, Chinese yam 100g.The acid and alkali-resistance infusion kettle is put in chopping after mixing in proportion, at room temperature, steeps 20 days with the above ethanol of 90 degree, and liquid and the dregs of a decoction that dipping is good carry out squeeze and filter, get filtrate after the separation; Described filtrate heating is concentrated into pasty state, puts into drying in oven, cooling is rear and grind to form fine-powdered, becomes pulvis.

Specific embodiment 5: the preparation method was when the formulation of Chinese medicine additive was paste: motherwort 130g, RADIX POLYGONI MULTIFLORI PREPARATA 130g, bighead atractylodes rhizome 120g, date 140g, fruit of glossy privet 120g, Chinese trumpet creeper 130g, root of herbaceous peony 1300g, bletilla 130g, Radix Astragali 120g, peach blossom 110g, Poria cocos 120g, reticulate millettia 130g, Radix Codonopsis 130g, mother-of-pearl 130g, Radix Angelicae Sinensis 130g, Flos Albiziae 140g, peach kernel 120g, rhizoma cyperi 120g, root of Dahurain angelica 130g, red sage root 130g, Fructus Corni 120g, coix seed 130g, Chinese yam 130g.Put into the ethanol heating and refluxing extraction 2 times, each 1 hour, No. 2 extracts merging are left standstill.Get medicinal extract; The dregs of a decoction that above-mentioned alcohol extract is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1 hour, No. 2 extracts merging are left standstill.Above-mentioned two kinds of extracts are merged, and the reduced pressure concentration relative density is the filtrate of 1.35 (80 ℃), and Recycled ethanol is with the medicinal extract of gained filtrate adjustment proportion to 1.06; Two kinds of medicinal extract are condensed into paste.

Various property of Chinese materia medica introductions in the Chinese medicine additive:

Mother-of-pearl: flat liver, checking exuberance of yang, arresting convulsion, hemostasis.Control dizzy, tinnitus, palpitaition, insomnia, demented, frightened epilepsy is spitted blood bleeding from five sense organs or subcutaneous tissue, metrorrhagia.Mother-of-pearl with the nacre powder of Pinctada martensii to rabbit after, calcium ion concentration in the blood and is given several indifferences behind the calcium carbonate.Its 30% sulphuric acid hydrolysis product contains: the amino acid such as leucine, methionine, alanine, glycine, glutamic acid, asparatate, to the auricular concha blood vessel of rabbit and blood pressure without effect, but can increase Isolated Toad heartbeat amplitude, reduce isolated rabbit intestines tension force, rabbit is had of short duration diuresis.Nacre 4N hydrochloric acid extraction liquid can suppress histamine to the contraction of the small intestine of guinea pig that exsomatizes.Its ether extracted liquid can suppress histamine to the contraction of intestinal tube, prevents that histamine from causing shock and the death of cavy; Though the anaphylactic shock guinea-pigs to horse serum sensitization can not prevent to internal organs allergy, such as the contraction to guinea pig in vitro intestinal tube, uterus, the tendency of inhibition being arranged then.

The RADIX POLYGONI MULTIFLORI PREPARATA RADIX POLYGONI MULTIFLORI PREPARATA be with Radix Polygoni Multiflori and black soya bean with the tuber of multiflower knotweed that dries after boiling, be simply filling liver kidney, benefiting essence-blood, the good medicine that nourishes heart and allay excitement.Be mainly used in treating because of diseases such as soreness and weakness of waist and knees that kidney deficiency and liver, essence and blood loss cause, dizzy, palpitation and insomnia, graying of hair.It is to bring into play by kidney tonifying, benefit essence, the effect of allaying excitement of nourishing blood that the crow of the fleece-flower root sends out function.RADIX POLYGONI MULTIFLORI PREPARATA has enrich and benefit essence and blood, and nourishing the liver is calmed the nerves, strengthening the bones and muscles, and the crow palpus that reinforces the kidney is seen Light-headedness for the deficiency of blood, palpitation and insomnia is forgetful, and is sallow weak, the dizzy tinnitus of liver kidney blood and essence asthenia, soreness and weakness of waist and knees, the diseases such as band, poliosis are collapsed in seminal emission.

The motherwort flavor is arduous, cool.Invigorate blood circulation, dispel silt, menstruation regulating, water disappears.The treatment menoxenia, threatened abortion difficult labour, placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, rushes down blood at hematuria, the carbuncle sore that swells.Motherwort contains the materials such as leonurine, fumaric acid, and the effects such as promoting blood circulation for regulating menstruation, hypotensive, inducing diuresis to reduce edema are arranged.

Fructus Corni cures mainly perverse trend fever and chills under the heart, in the temperature, by cold warm numbness, goes three worms, the merit that takes the reinforcing yin essence benefit essence of having made light of one's life by commiting suicide, five viscera settling, logical nine orifices, ends dribbling urination of a specified duration; For a long time clothes make eye bright, brute force all the year round.Fructus Corni has another name called cornus officinalis sieb et zucc, medicine jujube, real jujube, fructus corni, meat jujube etc., is China's rare traditional Chinese medicine commonly used, and applicating history is long.It is gentle with its benefit power, establishing-Yang and do not help fire, enriching yin and oiliness diaphragm, convergence and do not stay the evil special efficacy that waits by successive dynasties usefulness that medical science is liked.Zhang Zhongjing has been formulated " chinkuei shin chewan pills " take Fructus Corni as monarch.According to chemical analysis, Fructus Corni contains the active ingredients such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, having and strengthen immunity, anti-inflammatory, the pharmacological action such as antibiotic, is the simply medicine of commonly using in the tcm clinical practice.

Chinese yam is planted trace element because being rich in 18 seed amino acids and more than 10, and other mineral matter, so strengthening the spleen and stomach, tonifying lung kidney, tonifying middle-Jiao and Qi, invigorating the spleen qi-restoratives are arranged, the effects such as beneficial essence, beneficial heart and tranquilizing mind of reinforcing the kidney, saying of " all kinds of diseases and ailments are reinforced the kidney, controlled to invigorating the spleen help, taste essence, treats general debility " arranged in the Li Shizhen (1518-1593 A.D.) Compendium of Material Medica.Copper ion in the Chinese yam and connective tissue have very big help to the human development, vascular system disease there is obvious curative effects, calcium in the iron rod yam, bone, osteoporosis are decreased in the injury of the tissues, loss of tooth has high curative effect, pernio, diabetes, hepatitis, children's's diarrhea, enruesis, baby's indigestion, ulcerative stomatitis, pulmonary tuberculosis, the inferior patient of woman month band also there are good curative effect, with can be clear-headed and clear-sighted, promote longevity for a long time.

Date is rich in protein, fat, carbohydrate, carrotene, B family vitamin, vitamin C, citrin and the nutritional labeling traditional Chinese medicine theories such as calcium, phosphorus, iron and CAMP to be thought, red date has the effects such as qi-restoratives benefit gas, nourishing blood and tranquilization, strengthening the spleen and stomach, is the good health nutrient fruits of patient such as weakness of the spleen and the stomach, insufficiency of vital energy and blood, lassitude, insomnia and dreamful sleep.The date tonifying middle-Jiao and Qi, nourishing blood and tranquilization.It is few to be used for insufficiency of the spleen food, weak loose stool, hysteria of womam.Menstruation regulating is invigorated blood circulation in the energy promoting the circulation of qi.Be used for irregular menstruation, red collapsing, leukorrhea is the good merchantable brand of enriching blood.

The Radix Astragali is take qi-restoratives as main, can invigorating qi for strengthening superficies, and diuresis holder poison, apocenosis, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, sore cave in, purulence becomes not burst or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration, i.e. the abscess suppuration myogenic of for a long time disunion.Modern medicine study shows that the Radix Astragali includes and multiple antibiotic effective ingredient, and can strengthen the immunologic function of body, therefore can also be used for the generation of some infectious disease of prevention." book on Chinese herbal medicine meets former " carries: " Radix Astragali can all void of tonifying five zang organs, controls arteries and veins string spontaneous perspiration, rushes down yin fire, removes lung heat, losslessly then sends out, and has sweat then to end." be the good medicine of promoting resistance and defence disease.

Radix Codonopsis is China's traditional tonic commonly used, and the Radix Codonopsis that produce take area, Shangdang, Shanxi ancient times has tonifying middle-Jiao and Qi as top grade, the effect of invigorating the spleen benefit lung.Modern study, Radix Codonopsis contain various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, saponin and Alkaloid, have to strengthen immunity, hemangiectasis, step-down, improve microcirculation, strengthen the effect such as hematopoiesis function.The leucocyte that in addition chemotherapy radiotherapy is caused descends castering action is arranged.Radix Codonopsis has tonifying middle-Jiao and Qi, the effect of invigorating the spleen benefit lung.Be used for a little less than the spleen deficiency syndrome of the lung, the palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst etc." new compilation of materia medica " record: " tonifying middle-Jiao and Qi and taste, relieving thirst and restlessness.Middle gas is faint, mends in order to transfer, and is very smooth and proper.”

Poria cocos flavor is sweet, light, property flat, be used as medicine have clearing damp and promoting diuresis, the function of beneficial spleen and stomach, antitoxic heart-soothing and sedative.Modern medicine study: Poria cocos can enhanced machine body immunity function, pachymaran has significantly antitumor and protect the liver dirty effect.The Poria cocos slightly sweet flavor is flat, enters the heart, lung, the spleen channel.Has eliminating dampness and diuresis, strengthening the spleen and stomach, the effect of antitoxic heart-soothing and sedative.Can control difficult urination, the oedema turgor, phlegm and retained fluid is coughed contrary, and it is contrary to vomit, and vomiting during early pregnancy is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The Li Shui of Poria cocos reaches by strong fortune spleen PFT, and is different from the Chinese medicine of other direct Li Shui.Be used for splenasthenic diarrhea, the lower Poria cocos of band can invigorating the spleen, again can excreting dampness, and due to insufficiency of the spleen dysfunction of the spleen in transportation and transformation, have loose bowels, be with down, use the effect that Poria cocos has giving consideration to both the incidental and fundamental, often and the compatibilities such as Radix Codonopsis, the bighead atractylodes rhizome, Chinese yam.Can be used as the tonifying lung spleen, control the adjuvant of the deficiency of vital energy.

Coix seed is the Chinese medicine of commonly using. be again generally, the food often eaten, the property slightly sweet flavor is slightly cold, and has that inducing diuresis for removing edema, invigorating the spleen are dried, Shujin is except effects such as numbness, clearing away heat and eliminating pus, is damp-clearing drug commonly used.Coix seed is again a kind of beauty food, and normal food can keep human body skin gloss fine and smooth, eliminates acne, spot sparrow, senile plaque expelling, cyasma, butterfly macules, to furfur, acne, chap, pachylosis etc. has good efficacy.The kind Renhe root of the seed of Job's tears can be used as medicine again and cure the disease.Li Shizhen (1518-1593 A.D.) is put down in writing in Compendium of Material Medica: seed of Job's tears energy, and " invigorating spleen and reinforcing stomach, wind prevailing over dampness is removed in the tonifying lung heat-clearing.The food of cooking a meal is controlled cold air.Fry in shallow oil drink, diuresis heat is drenched." in recent years, a large amount of scientific research and clinical practices prove, the seed of Job's tears or a kind of cancer therapy drug, and Preliminary Identification, it can reach more than 35% the inhibiting rate of cancer.

Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.It is few to be used for insufficiency of the spleen food, and abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body.Baizhu volatile oil has inhibitory action to mouse EC, lymphosarcoma ascitic type, the cancer of the esophagus (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Remarkable inhibitory action is also arranged." property of medicine opinion " carries it: monarch, and it is sweet to distinguish the flavor of, and suffering is nontoxic.Can main large wandering arthritis, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken place food that disappears, sputum is removed in appetizing, except fever and chills, lets out under ending.Interarea light is pleased, and preserves youthful looks, and goes to deceive.The swelling of harnessing the river is full, tells to vomit contraryly, and crymodynia in the abdomen is vomited and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.

The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, relieving restlessness clears away heart-fire.Be used for irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest ventral spine pain, and hot numbness pain, sore swells and ache, dysphoria and insomnia.Be used for the sternal rib hypochondriac pain, arthralgia due to wind-dampness, the abdominal mass caking, sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, bitterly have good effect through amenorrhoea.. " detailed outline " carries: the red sage root, by " the sensible opinion of married woman " cloud, Siwu Tang is controlled the gynecopathy, pays no attention to antenatal postpartum, through water what, all can be general, the only flavor red sage root is loose, cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, and the stillborn foetus that falls, under only metrorrhagia stagnates, the menstruation regulating arteries and veins.The Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves effects such as circulating, remove intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote the liver blood circulation to be beneficial to liver cell regeneration.

Reticulate millettia property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, vein relaxing.Be used for irregular menstruation, the deficiency of blood is sallow, paralysis and numbness, and arthralgia due to wind-dampness is activated blood and relaxed tendons; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carry it can cure numb in every limb; Quadriplegia; Arthralgia due to wind-dampness; Chinese trumpet creeper, reticulate millettia is for oral administration to be that the treatment blood stasis is not loose, the good medicine that nourishing blood silt is invigorated blood circulation.

Radix Angelicae Sinensis: its flavor is sweet and weigh, so specially can enrich blood, its gas is light and hot, thus again can promoting circulation of blood, and bowl spares has, in the row benefit is arranged, the gas medicine in the sincere blood, the also panacea in the blood.About mending to mend then of assistant, thus can support nutrition blood, the tonifying Qi production of sperm, five viscera settling, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the pain defaecation of dispelling, relieving rigidity of muscles and joints is controlled contraction, paralysis, the card such as dry, puckery.Seek void and the exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and table is not held back the person, and assistant can be shown again admittedly with rheum officinale and so on.Precisely because gas Xin Erdong, so want its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

The hot little hardship of rhizoma cyperi is sweet, and flat function cures mainly: the Xie Yu that regulates the flow of vital energy, menstruction regulating and pain relieving.Be used for stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, indigestion, irregular menstruation is through closing dysmenorrhoea, cold hernia stomachache, swollen breasts." detailed outline " carries it: the cold epidemic disease of gas when loose, and sharp three warmers, Xie Liuyu, the diet that disappears gathers, and the phlegm and retained fluid ruffian is full, and instep is swollen, abdominal distension, beriberi is ended trusted subordinate, limbs, head, order, tooth, all pains of ear, and ulcer sores is spitted blood, lower blood, hematuria, under married woman's uterine bleeding band, month time is uncomfortable, tire all kinds of diseases and ailments in front postpartum.

Peach kernel is bitter, and is sweet, puts down the special medicine that closes for blood stasis blood.Bitter to let out stagnant blood, the new blood of Gan Yisheng." medicineization justice ": peach kernel, bitter can rush down blood-head, and it is dry that the body profit can be grown intestines.If it is multiplex that gross weight grinds, walk Liver Channel, the main broken blood that holds, month by month water, and pain all over, four limbs wood numbness, left hemiplegia, left sufficient patient is relaxed through the promoting circulation of blood of invigorating blood circulation with it, the merit that eliminate blood stasis and promote tissue regeneration is arranged if few usefulness is mashed in peeling, enters large intestine, controlling blood depletion just closes, blood is dry just difficult, with its make moist cool blood and blood, the logical power that stagnates of knot is arranged out.

A kind of traditional Chinese medicine material of Chinese trumpet creeper has promoting circulation of blood and removes the stasis of blood, cooling blood, expelling wind dampness removing, and clearing heat and detoxicating, it is sad to distinguish the flavor of, and cold nature is returned liver, pericardium channel, function promoting blood circulation to remove blood stasis, cooling blood, expelling wind.Cure mainly irregular menstruation, through closing swollen, the pruitus of abdominal mass, postpartum breast. " Amplification on Materia Medica addendum ": Chinese trumpet creeper, control the key medicine of pain in the blood also, and the tonifying yin victory is very, be stamped and keep and walk alone, in the married woman side multiplex how." Nanning City's medicine will ": the merit of eliminating inflammation and expelling toxin, hemostasis and pain-relieving, apocenosis myogenic is arranged, control red dysentery characterized by white mucous stool.

The fruit of glossy privet is used for the order of the deficiency of liver-yin and kidney-yin and secretly fails to understand hypopsia, poliosis, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly get effect.It is secretly not clear to control order, often joins cultivated land, and mother-of-pearl is equal to usefulness, controls poliosis, often joins the same usefulness of mulberries, and the root bark of Chinese wolf-berry is often joined in fever due to yin deficiency.The deficiency of liver-yin and kidney-yin, Light-headedness, seminal emission tinnitus, soreness and weakness of waist and knees, poliosis, coronary heart disease, hyperlipidemia, hypertension, chronic hepatitis.Protective effect research to liver is thought, the fruit of glossy privet contains oleanolic acid, give rat skin lower injection, can reduce serum glutamic pyruvic transminase, hepatic injury to Carbon Tetrachloride Induced has obvious protective effect, and can promote liver cell regeneration. and oleanolic acid also can make in the liver triglycerides accumulate that minimizings, degeneration of liver cells necrosis obviously alleviate, glycogen is accumulated increase, the decline of serum Y globulin; Mitochondrial swelling and the sex change of endoplasmic reticulum vesica alleviates, the matter inflammatory reaction weakens between hepatic tissue in the visible liver cell of ultra microstructure.

Bletilla is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.Be used for hemoptysis and spit blood traumatism and bleeding, sore swollen toxin, chapped skin; The pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Shennong's Herbal: " main carbuncle swells, dislikes sore, loses subcutaneous ulcer, the dead flesh of impairment of yin, perverse trend in the stomach "; Compendium of Material Medica: " smell (root) is bitter, flat, nontoxic.

Root of Dahurain angelica meridian distribution of property and flavor: suffering, temperature.Attach to the lung and stomach meridians.Expelling wind and clearing away cold, understand things pain-stopping, detumescence and apocenosis, eliminating dampness is ended band." Japan hanako materia medica ": control the hot eyes triangular mass of mucous membrane growing from the inner corner of the eye, and tire patching leakage landing, broken place blood is mended new blood, acute mastitis, carbuncle on the back, scrofula, intestines wind, hemorrhoid complicated by anal fistula, and apocenosis, desolation, mange, the pain relieving myogenic is gone face Shao-defect scar.

Peach blossom is rose family cherry peach blossom (latin name: dry flower Prunus persica).Middle unit have the medical value of dredging the channel, skin care.The beautification function of peach blossom, mainly be come from contain that Kaempferol, perfume (or spice), beans are smart in spending, trifolin and vitamin A, the nutriments such as B, C.These substance hemangiectasis, promotion of blood circulation, moist skin, improve blood circulation, promote skin-nourishing and oxygen supply, make the lipofuscin element that promotes human senility accelerate to drain, prevent melanin chronic deposition in skin, thereby can effectively prevent chloasma, freckle, blackspot, also be rich in vegetable protein and the amino acid that is free state in the flowering peach, be absorbed by the skin easily, to preventing and treating dry skin, coarse and wrinkles etc. effectively also can strengthen the resistance against diseases of skin, thereby prevent and treat skin disease, seborrhea, suppurative dermatitis, scurvy etc., of great advantage to skin.

The root of herbaceous peony enters liver, the spleen channel, nourishing blood and liver, and slow middle pain relieving, astringe yin is received sweat.Control chest abdomen pain over the hypochondriac region, rush down dysentery stomachache, spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, band is lower, and it is obstructed that married woman's blood closes, and the hemostasis that disappears can lose purulence, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui brings down a fever, relieving restlessness, beneficial gas, day hot disease of row, the pest miasma, frightened mad, married woman's blood fortune, and intestines wind are rushed down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, the sore scabies, headache makes eye bright, and hot eyes is exerted meat.The many tonifying Qi of redness of the skin or complexion person, white person controls blood.

Flos Albiziae contains the silk tree glucoside, tannin, and resolving stagnation for tranquilization, the appetizing of regulating the flow of vital energy, activating collaterals to relieve pain is used for confused and worried, melancholy insomnia.It is uncomfortable in chest to control pent-up, and insomnia is forgetful, and acute conjunctivitis can five viscera settling, and will, pleases color, have preferably keep fit, calm, the effect of calming the nerves, improve looks, also be to treat neurasthenic good merchantable brand.Also has clearing away summerheat, the face-beautifying and spot-removing effect such as relieve the effect of alcohol." book on Chinese herbal medicine warp " said: " Flos Albiziae energy five viscera settling, and will are pleased color." especially to the pregnant woman, have preferably keep fit, calm, the effect of calming the nerves, improve looks, also be to treat neurasthenic good merchantable brand.

The present invention selects smell gentle, removes dampness by means of aromatics, and spot is removed in whitening, and traditional Chinese medicine ingredients promoting blood circulation and removing blood stasis does not produce in the past Chinese medicine niff, and being added on does not affect mouthfeel in the fish scale jelly, and unique flavor, allows people's aftertaste.

1, acute toxicity test

The application mouse carries out acute toxicity testing and shows: mouse oral administration gavage Chinese medicine additive paste of the present invention, under 456.8g crude drug/kg dosage, the light activity minimizing appears in mouse after the administration, recover normal about 1 hour, Continuous Observation is 7 days after the administration, none animal dead, its overall health of patients, diet, to take the photograph water, urine and body weight gain all normal, and experimental result shows: the maximum dosage-feeding of mouse oral administration gavage Chinese medicine additive of the present invention is 488.8g crude drug/kg/d (LD50＞456.8g crude drug/g).Chinese medicine additive clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; Press batheroom scale, the dosis tolerata of mouse stomach Chinese medicine additive of the present invention is 4568 times of clinical patient.Point out this additive totally nontoxic, clinical drug safety.

2, long term toxicity test

Select the SD rat, give variable concentrations (18.0,6.0, the Chinese medicine additive pulvis of the present invention of 2.0g crude drug/kg), every day gavage once, continuous 90 days, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half) after the last administration, live extremely after all the other 1/2 animals continuation observed for 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the changes of weight of animal, after the administration 90 days and carry out hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) in 2 weeks of drug withdrawal and the index checkings such as blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, Histopathology.

Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain all change without unusual; Three dosage groups and control group hematological examination, blood biochemical are learned, the urine biochemical analysis is all in normal range (NR), between group without significant difference; Each is organized the main organs histopathological examination and shows no obvious abnormalities.The These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test Chinese medicine preparation of the present invention high, medium and low three dosage (18.0,6.0, the 2.0g crude drug/kg) administration in continuous 90 days has no significant effect rat, without clear and definite toxicity target organ and sensitive indicator, the convalescence observation also has no the retardance toxic reaction, points out the dosage safety of Chinese medicine additive clinical practice of the present invention higher.

3, Chinese medicine additive of the present invention is through 6 months long-term toxicity test for animals result of gastric infusion: the SD rat is divided into three groups, every group 30, male and female half and half (being divided into high, medium and low three dosage groups, 10 every group), wherein first group through gavage to physiological saline; Second group through gavage to Chinese medicine additive granule of the present invention, dosage is 0.25g, 2.5g and 12.5g/kg.d; The 3rd group is 0.5mg, 5.0mg and 50.0mg/kg.d through gavage to the dosage of Lovastatin.During administration, observe respectively that clinical manifestation, hematology, blood after each treated animal administration is biochemical, the indexs such as organ coefficient and histopathology carry out the evaluation of drug toxicity.Result of study: main toxic reaction shows Lovastatin 50mg/kg.d and 5.0mg group, shows after the administration that reaction and the symptoms such as salivation, hair are fluffy, busy, diarrhoea, step have appearred in the SD rat, total food ration with lose weight; Blood test shows that total white blood cells increases to some extent, red blood cell sum, content of hemoglobin and platelet count obviously descend (P all＜0.05); Blood biochemistry checking shows that ALT, AST, ALP and CK raise 1～8 times (P all＜0.05), and creatinine and urea nitrogen raise (P all＜0.05) to some extent, but do not cause animal dead; Histopathological analysis result shows that Lovastatin 50mg/kg.d group the liver-kidney diseases reason similar to the people occurred and changed.And similar reaction does not all appear in physiological saline group and Chinese medicine additive 0.25g of the present invention, 2.5g and three dosage groups of 12.5g/kg.d and Lovastatin 0.5mg/kg.d dosage group during whole administration, at the convalescence viewing duration, the symptom that each treated animal of reaction the occurs recovery normal condition that fades away.As seen Chinese medicine additive of the present invention not only can reduce the toxic and side effect of Lovastatin, and can make the clinical non-toxic of Lovastatin increase to 5～25 times (P all＜0.01).

The Chinese medicine additive pharmacodynamic experiment

Animal: the used mouse of experimental example is the Kunming kind, is provided by Shandong Medical University's biology laboratory.

Model is built group: the blank group, and granule of the present invention, the Yunnan Baiyao group, Xiaoyao San is commercially available.

1, function of promoting blood circulation to disperse blood clots

(1), on the impact of clotting time of mice and plasma fibrinogen content

Clotting time of mice the results are shown in Table 1.Compare with the blank group, the clotting time of 800mg/kg of the present invention, 1600mg/kg dosage group mouse obviously prolongs (P＜0.01).Compare with the Yunnan Baiyao group, the clotting time does not have significant difference (P＜0.05).

The mice plasma fibrinogen content the results are shown in Table 2.Compare with the blank group, 1600mg/kg dosage of the present invention has utmost point appreciable impact (P＜0.01) to the mice plasma fibrinogen content, and other each dosage group all has no significant effect (P＞0.05).

Table 1, on the impact of clotting time of mice (X ± SD)

Compare * P＜0.05 with the blank group.

Table 2, on the impact of mice plasma fibrinogen content (X ± SD)

Compare * P=0.05 with the blank group; * P＜0.01.

3.3 the mensuration of liver, the total SOD of skin, ZuCu-SOD, MDA activity

3.3.1 mensuration and the statistics of the total SOD activity of liver

With the contrast of blank group, the total SOD activity value of the liver of model group and low dose group of the present invention descends, and has extremely significant difference.With the model group contrast, the dosage group has extremely significant difference among treatment Xiaoyao San, the present invention.See Table 3.The total SOD of mouse model liver is active to descend, and it is active that Xiaoyao San, the high, medium and low dosage of the present invention all can improve the total SOD of liver, and wherein the dosage group has extremely significantly change in Xiaoyao San, the composition.

3.3.2 mensuration and the statistics of the total SOD activity of skin

With the contrast of blank group, the total SOD activity value of the skin of model group and low dose group of the present invention descends, and has significant difference; Xiaoyao San, the present invention's height, middle dosage group are organized without significant difference with blank.With the model group contrast, treatment Xiaoyao San, the present invention's height, middle dosage group have extremely significant difference, and there were significant differences for low dose group.See Table 2.As seen the total SOD of the liver energy stagnation type mouse model skin that chronic constraint+ultraviolet ray+progesterone method is set up is active to descend, it is active that Xiaoyao San, the high, medium and low dosage of the present invention all can improve the total SOD of skin, wherein Xiaoyao San, the present invention's height, middle dosage treatment have extremely significantly effect

There is not significant difference with blank group after the treatment.

The variation of table 2 liver, the total SOD activity of skin (x ± s ,/mg albumen)

Annotate: dead 2 of Xiaoyao San treatment group, sample size is 8.Compare * P＜0.05, * * P＜0.01 with the blank group; Compare ★ P＜0.05, ★ ★ P＜0.01 with model group.Liver F=4.524, skin F=5.112.

Claims

1. a beauty treatment fish scale jelly is characterized in that, comprises in the following raw material one or more: fish scale, Chinese prickly ash, shallot, ginger, aniseed, spiceleaf, cassia bark, the root of straight ladybell, salt, cooking wine, Chinese medicine additive, water.

2. described beauty treatment fish scale jelly according to claim 1, it is characterized in that, described Chinese medicine additive comprises the bulk drug of following parts by weight: 10～20 parts of motherworts, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts in date, 10～20 parts of the fruit of glossy privets, 10～20 parts of Chinese trumpet creepers, 10～20 parts of the root of herbaceous peonys, 10～20 parts of bletillas, 10～20 parts of the Radixs Astragali, 10～20 parts in peach blossom, 10～20 parts in Poria cocos, 10～20 parts of reticulate millettias, 10～20 parts of Radix Codonopsis, 10～20 parts of mother-of-pearls, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Flos Albiziaes, 10～20 parts in peach kernel, 10～20 parts of rhizoma cyperis, 10～20 parts of the roots of Dahurain angelica, 10～20 parts of the reds sage root, 10～20 parts of Fructus Cornis, 10～20 parts of coix seeds, 10～20 parts of Chinese yams.

3. described beauty treatment fish scale jelly according to claim 1, it is characterized in that, described Chinese medicine additive comprises the bulk drug of following parts by weight: 10～15 parts of motherworts, 10～15 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～15 parts of the bighead atractylodes rhizomes, 10～15 parts in date, 10～15 parts of the fruit of glossy privets, 10～15 parts of Chinese trumpet creepers, 10～15 parts of the root of herbaceous peonys, 10～15 parts of bletillas, 10～15 parts of the Radixs Astragali, 10～15 parts in peach blossom, 10～20 parts in Poria cocos, 10～20 parts of reticulate millettias, 10～20 parts of Radix Codonopsis, 10～20 parts of mother-of-pearls, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Flos Albiziaes, 10～20 parts in peach kernel, 10～20 parts of rhizoma cyperis, 10～20 parts of the roots of Dahurain angelica, 10～20 parts of the reds sage root, 10～20 parts of Fructus Cornis, 10～20 parts of coix seeds, 10～20 parts of Chinese yams.

4. described beauty treatment fish scale jelly according to claim 1, it is characterized in that, described Chinese medicine additive comprises the bulk drug of following parts by weight: 10～20 parts of motherworts, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts in date, 10～20 parts of the fruit of glossy privets, 10～20 parts of Chinese trumpet creepers, 10～20 parts of the root of herbaceous peonys, 10～20 parts of bletillas, 10～20 parts of the Radixs Astragali, 10～20 parts in peach blossom, 10～15 parts in Poria cocos, 10～15 parts of reticulate millettias, 10～15 parts of Radix Codonopsis, 10～15 parts of mother-of-pearls, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Flos Albiziaes, 10～15 parts in peach kernel, 10～15 parts of rhizoma cyperis, 10～15 parts of the roots of Dahurain angelica, 10～15 parts of the reds sage root, 10～15 parts of Fructus Cornis, 10～15 parts of coix seeds, 10～15 parts of Chinese yams.

5. each described beauty treatment fish scale jelly is characterized in that according to claim 1 ~ 4, comprises the raw material of following weight portion: 300 ~ 500 parts on fish scale, 3 ~ 6 parts in Chinese prickly ash, 3 ~ 6 parts in shallot, 3 ~ 6 parts in ginger, 3 ~ 6 parts of aniseed, 3 ~ 6 parts of spiceleafs, 3 ~ 6 parts on cassia bark, 3 ~ 6 parts of the root of straight ladybell, 10 ~ 20 parts of salt, 10 ~ 20 parts of cooking wine, 20 ~ 40 parts of Chinese medicine additives, 300 ~ 1000 parts in water.

6. Chinese medicine additive as using in the beauty treatment fish scale jelly as described in each among the claim 2-4.

7. the preparation method of Chinese medicine additive as claimed in claim 6 is characterized in that described Chinese medicine additive formulation is granule, and its preparation process is:

A. described bulk drug is put into the pulverizer grinding and sieving,

8. described preparation method according to claim 7 is characterized in that, among the described step a, described bulk drug is put into cross 120 order dusting covers after pulverizer is pulverized, and the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves for subsequent use; Among the described step b, the rear remaining particle that sieves is put into the ethanol heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts merging are left standstill; Among the described step c, the dregs of a decoction that above-mentioned alcohol extract is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts merging are left standstill.

9. described preparation method according to claim 7, it is characterized in that, in the described steps d above-mentioned two kinds of extracts are merged, 1.38 filtrate when the reduced pressure concentration relative density is 70 ℃, Recycled ethanol, gained filtrate is adjusted proportion to 1.06, pass into spray dryer and carry out spray-drying, the compressed air pressure of crossing the spray dryer shower nozzle is 4kg/m ², the hothouse hot stream temperature is 100 ℃, gets raw material medicinal powder; The raw material fine powder that obtains after sieving mixed with raw material medicinal powder add dextrin and granulate.

10. preparation method of beauty treatment fish scale jelly as claimed in claim 5, it is characterized in that, preparation process is: the fish scale that scrapes, put after cleaning up and add 1 ~ 2 times of water gaging of weight portion in the pot, used coddle after boiling instead 1 hour, boil that fish scale bleaches, curling so that soup in the pasty state, then pull fishing squama residue out; Put into the Chinese prickly ash that is contained in seasoner vessel, shallot, ginger, aniseed, spiceleaf, cassia bark, the root of straight ladybell, then with salt, cooking wine; After again boiling, add Chinese medicine additive and mix thoroughly, endure half an hour, pour container into, after the cooling, jelly.