CN103054073B - Beautifying fish scale jelly and preparation method thereof - Google Patents

Abstract

The invention provides a beautifying fish scale jelly. Raw materials of the beautifying fish scale jelly comprise one or more of scales, peppers, green Chinese onions, gingers, aniseeds, myrcia, cinnamons, adenophora stricta, salt, cooking wine, a traditional Chinese medicine additive and water. Raw material medicines of the traditional Chinese medicine additive of the fish scale jelly comprise motherwort, radix polygoni multiflori praeparata, bighead atractylodes rhizome, Chinese-dates, rhizoma bletillae, glossy privet fruits, Chinese trumpet creeper, radix paeoniae alba, rhizoma bletillae, astragalus mongholicus, peach blossom, poria cocos, caulis spatholobi, codonopsis pilosula, nacre mother of pearl, angelica sinensis, albizia flower, peach kernels, rhizoma cyperi, radix angelicae, the root of red-rooted salvia, dogwoods, semen coicis and rhizoma dioscoreae. According to the invention, collagens can be supplemented and nutritions can be increased; the mouthfeel is distinctive; as traditional Chinese medicines for promoting circulation and removing stasis are added, the medicines are fresh in mouth feel and cannot affect smells of the fish scale jelly; the beautifying fish scale jelly provided by the invention has the effects of making skins soft and smooth, removing wrinkles, supplementing lost collagens, promoting circulation and removing stasis after being used for a long time; and moreover, the beautifying fish scale jelly provided by the invention has the advantages of simple and easily-obtained raw materials and simple production method and is especially suitable for people loving beauty to use.

Description

A kind of beauty treatment fish scale jelly and preparation method thereof

Technical field

The present invention relates to contain the food that derives from animal, plant composition, particularly a kind of beauty treatment fish scale jelly and preparation method thereof.

Background technology

Fish scale, conventionally all scrapes off it and throws away when refuse.In fact, fish scale contains rich in protein, fat and multivitamin, also has the trace element of iron, zinc, calcium and multiple needed by human, and colloid.In fish scale, also contain multiple unrighted acid, can reduce cholesterol gathering on vascular wall, there is the effects such as prevention of arterial sclerosis, hypertension and heart disease.Along with the raising day by day of living standard, people are more and more higher to the requirement of diet, and so-called it is difficult to cater for all tastes, and taste is more and more unique.Eat healthyly, the exquisiteness of eating has become mainstream of society thought gradually.How on the basis of not destroying the nutritive value of food materials own, can develop again innovation, improve mouthfeel and unique flavor, adapt to individual character and select to have become the huge challenge that food service industry faces.Food is no longer that full abdomen is the primary, collect health-preserving, beauty treatment, and multi-functional being integrated of reducing weight, more and more higher social growth requirement just can meet the demands.

Nutritionist studies discovery, and fish scale is special health food.It contains more lecithin, has and strengthens memory, slow effect of prolonging cell ageing.Fish phosphorus contains rich in protein, fat and multivitamin, also has the micronutrient of iron, zinc, calcium and multiple needed by human, and wherein the content of calcium, phosphorus is very high, can preventing child rickets and middle-aged and old osteoporosis and fracture.Brainstrust is found, contained multiple unrighted acid in fish scale, can in blood, help to transmit and chyle fat with protein-bonded form, reduce cholesterol and deposit on vascular wall, there is the multiple effects such as the artery sclerosis of preventing, preventing hypertension and heart disease.

Fish scale is the sclerotin that the collagen of fish skin corium generates, and formal name used at school is ichthylepidin, and it demonstrates effect out of the ordinary at medical domain.The 6-extracting from fish scale dredges for guanine, clinical treatment acute leukemia, and efficient is 70%～75%; And cancer of the stomach, lymphadenoma are also had to special effect.In fish scale, contain a large amount of collagens.Collagen, is the beauty treatment much-talked-about topic often appearing at now in people's mouth, from cosmetics for external use, to oral liquid, capsule, can say, can see its shadow everywhere.Collagen also claims ossein, is a kind of thread collagen fabric, and its major physiological function is to do the adhesion substance of connective tissue, can make the solid high resilience of skin, and it is present in the positions such as human body skin, bone, tendon.

Concerning skin, it and elastic fibers make a concerted effort to form mesh-supported body, for skin corium provides stable strong support.With advancing age, the collagen content in human body can reduce gradually, and mesh-supported body will lose original elasticity gradually, and when elasticity and the moisturizing degree of skin corium reduce, skin just there will be the stereotype such as wrinkle, color spot phenomenon.Skin is made up of epidermis, corium, subcutaneous fat etc., and the body of skin is corium, and collagen accounts for the more than 70% of protein content content in dermal cell.The health of skin has two large key---crease-resistant and moisturizings, and collagen makes cell become plentiful, complete, keeps skin elasticity and moistening, effectively prevents aging.Fish scale collagen and other collagen ratios, its protein easily decomposes, easily digested, absorption.It is obvious that people take rear effect, can increase the amino acid in blood, can promote again collagen to generate simultaneously.

Summary of the invention

Technical problem to be solved by this invention is, as the waste material of daily life, contains a large amount of collagens in fish scale.Collagen is often to appear at now cosmetic good merchantable brand in people's mouth.Fish scale is the sclerotin that the collagen of fish skin corium generates, and formal name used at school is ichthylepidin, and it demonstrates effect out of the ordinary at medical domain.How turning waste into wealth, making the maximum performance of fish scale skin makeup effect is emphasis of the present invention.The present invention chooses and all belongs to the dirty product of heat-clearing profit, does not destroy the mouthfeel of fish scale jelly.The present invention have nti-freckle crease-resistant, profit in vain effect.Being applicable to skin colour calmness, wrinkle, to increase women edible.Use, can make skin delicacy lubricious for a long time, removes wrinkle, supplements the collagen running off, and more has good efficacy promoting blood circulation and removing blood stasis.

For solving the problems of the technologies described above, the invention provides a kind of beauty treatment fish scale jelly, comprise one or more in following raw material: fish scale, Chinese prickly ash, shallot, ginger, aniseed, spiceleaf, cassia bark, the root of straight ladybell, salt, cooking wine, Chinese medicine additive, water.

Described Chinese medicine additive can comprise the bulk drug of following parts by weight: 10～20 parts of motherworts, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts, date, 10～20 parts of the fruit of glossy privets, 10～20 parts of Chinese trumpet creepers, 10～20 parts of the root of herbaceous peonys, 10～20 parts of bletillas, 10～20 parts of the Radixs Astragali, 10～20 parts, peach blossom, 10～20 parts, Poria cocos, 10～20 parts of reticulate millettias, 10～20 parts of Radix Codonopsis, 10～20 parts of mother-of-pearls, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Flos Albiziaes, 10～20 parts, peach kernel, 10～20 parts of rhizoma cyperis, 10～20 parts of the roots of Dahurain angelica, 10～20 parts of the reds sage root, 10～20 parts of Fructus Cornis, 10～20 parts of coix seeds, 10～20 parts of Chinese yams.

Described Chinese medicine additive can comprise the bulk drug of following parts by weight: 10～15 parts of motherworts, 10～15 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～15 parts of the bighead atractylodes rhizomes, 10～15 parts, date, 10～15 parts of the fruit of glossy privets, 10～15 parts of Chinese trumpet creepers, 10～15 parts of the root of herbaceous peonys, 10～15 parts of bletillas, 10～15 parts of the Radixs Astragali, 10～15 parts, peach blossom, 10～20 parts, Poria cocos, 10～20 parts of reticulate millettias, 10～20 parts of Radix Codonopsis, 10～20 parts of mother-of-pearls, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Flos Albiziaes, 10～20 parts, peach kernel, 10～20 parts of rhizoma cyperis, 10～20 parts of the roots of Dahurain angelica, 10～20 parts of the reds sage root, 10～20 parts of Fructus Cornis, 10～20 parts of coix seeds, 10～20 parts of Chinese yams.

Described Chinese medicine additive can comprise the bulk drug of following parts by weight: 10～20 parts of motherworts, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts, date, 10～20 parts of the fruit of glossy privets, 10～20 parts of Chinese trumpet creepers, 10～20 parts of the root of herbaceous peonys, 10～20 parts of bletillas, 10～20 parts of the Radixs Astragali, 10～20 parts, peach blossom, 10～15 parts, Poria cocos, 10～15 parts of reticulate millettias, 10～15 parts of Radix Codonopsis, 10～15 parts of mother-of-pearls, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Flos Albiziaes, 10～15 parts, peach kernel, 10～15 parts of rhizoma cyperis, 10～15 parts of the roots of Dahurain angelica, 10～15 parts of the reds sage root, 10～15 parts of Fructus Cornis, 10～15 parts of coix seeds, 10～15 parts of Chinese yams.

Described beauty treatment fish scale jelly, preferably include the raw material of following weight portion: 300 ~ 500 parts, fish scale, 3 ~ 6 parts, Chinese prickly ash, 3 ~ 6 parts, shallot, 3 ~ 6 parts, ginger, 3 ~ 6 parts of aniseed, 3 ~ 6 parts of spiceleafs, 3 ~ 6 parts, cassia bark, 3 ~ 6 parts of the root of straight ladybell, 10 ~ 20 parts of salt, 10 ~ 20 parts of cooking wine, 20 ~ 40 parts of Chinese medicine additives, 300 ~ 1000 parts, water.

For solving the problems of the technologies described above, the present invention also provides the Chinese medicine additive using in a kind of beauty treatment fish scale jelly described above.

For solving the problems of the technologies described above, the present invention provides again a kind of preparation method of described Chinese medicine additive, and described Chinese medicine additive formulation is granule, and its preparation process is:

A. described bulk drug is put into pulverizer grinding and sieving,

B. particle remaining after sieving is put into ethanol heating and refluxing extraction 2 times;

C. get again the dregs of a decoction after above-mentioned alcohol extract, the heating and refluxing extraction that adds water 2 times;

D. above-mentioned two kinds of extracts are merged, decompression recycling ethanol spraying are dry, obtain medicinal powder; The fine powder that mixing sieves obtains adds dextrin and granulates.

In described step a, described bulk drug is put into after pulverizer is pulverized and crossed 120 order dusting covers, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves for subsequent use; In described step b, particle remaining after sieving is put into ethanol heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts are merged and left standstill; In described step c, the dregs of a decoction that above-mentioned alcohol extract is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts are merged and are left standstill.

In described steps d, above-mentioned two kinds of extracts are merged, 1.38 filtrate when reduced pressure concentration relative density is 70 DEG C, reclaims ethanol, and gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of crossing spray dryer shower nozzle is 4kg/m ², hothouse hot stream temperature is 100 DEG C, obtains raw material medicinal powder; The raw material fine powder obtaining after sieving is mixed with raw material medicinal powder and add dextrin granulation.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of described beauty treatment fish scale jelly, preparation process is: the fish scale scraping, after cleaning up, put and in pot, add 1 ~ 2 times of water gaging of weight portion, after boiling, use coddle instead 1 hour, boil that fish scale bleaches, curling so that soup in the pasty state, then pull fishing squama residue out; Put into the Chinese prickly ash that is contained in seasoner vessel, shallot, ginger, aniseed, spiceleaf, cassia bark, the root of straight ladybell, then with salt, cooking wine; After again boiling, add Chinese medicine additive to mix thoroughly, endure half an hour, pour container into, cooling after, jelly.

Chinese medicine fish scale jelly unique flavor provided by the invention, mouthfeel is good, has the double action of the property of medicine and trophism concurrently, both can supplement increase collagen, can have additional nutrients again; Mouthfeel uniqueness; Add some Chinese medicines promoting blood circulation and removing blood stasis, the most mouthfeel of these medicinal materials is light, does not affect the taste of fish scale jelly, makes people be easy to accept, and more can reach preferably skin-care and beautifying, replenishing collagen, effect of removal color spot.And tasty, unique flavor; Without any the side effect of food security.Adopt brand-new Chinese medicine additive, reach the requirement of pollution-free food pure natural, can obtain good economic benefit.Human body holistic health is fundamentally protected and coordinated to Chinese herb feed additive.The present invention chooses and all belongs to the dirty product of heat-clearing profit, does not destroy the mouthfeel of fish scale jelly.The present invention have nti-freckle crease-resistant, profit in vain effect.Being applicable to skin colour calmness, wrinkle, to increase women edible.Use, can make skin delicacy lubricious for a long time, removes wrinkle, supplements the collagen running off, and more have good efficacy promoting blood circulation and removing blood stasis, and raw material is simple and easy to get, and production method is simple, is particularly suitable for the vast personage of liking to be beautiful and uses.

Detailed description of the invention

Fish, as the cuisines on dining table, have a large amount of fish to make delicacies and allow people taste every day.But fish scale is lost as discarded object always, fish scale contains rich in protein, fat and multivitamin in fact, also has the trace element of iron, zinc, calcium and multiple needed by human, and colloid.In fish scale, also contain multiple unrighted acid, can reduce cholesterol gathering on vascular wall, there is the effects such as prevention of arterial sclerosis, hypertension and heart disease.

Nutritionist studies discovery, and fish scale is special health food.It contains more lecithin, has and strengthens memory, slow effect of prolonging cell ageing.Fish phosphorus contains rich in protein, fat and multivitamin, also has the micronutrient of iron, zinc, calcium and multiple needed by human, and wherein the content of calcium, phosphorus is very high, can preventing child rickets and middle-aged and old osteoporosis and fracture.Brainstrust is found, contained multiple unrighted acid in fish scale, can in blood, help to transmit and chyle fat with protein-bonded form, reduce cholesterol and deposit on vascular wall, there is the multiple effects such as the artery sclerosis of preventing, preventing hypertension and heart disease.

Fish scale is the sclerotin that the collagen of fish skin corium generates, and formal name used at school is ichthylepidin, and it demonstrates effect out of the ordinary at medical domain.The 6-extracting from fish scale dredges for guanine, clinical treatment acute leukemia, and efficient is 70%～75%; And cancer of the stomach, lymphadenoma are also had to special effect.In fish scale, contain a large amount of collagens.Collagen, is the beauty treatment much-talked-about topic often appearing at now in people's mouth, from cosmetics for external use, to oral liquid, capsule, can say, can see its shadow everywhere.Collagen also claims ossein, is a kind of thread collagen fabric, and its major physiological function is to do the adhesion substance of connective tissue, can make the solid high resilience of skin, and it is present in the positions such as human body skin, bone, tendon.

The present invention has the collagen of the loss of supplementing, and more have good efficacy promoting blood circulation and removing blood stasis, and raw material is simple and easy to get.

Detailed description of the invention 1: get 500g fish scale, make fish scale gelation, water will add less, institute's water consumption is 800g, uses coddle instead 1 hour after boiling, boil that fish scale bleaches, curling so that soup in the pasty state, then pull fishing squama residue out; Put into the Chinese prickly ash 4g that is contained in seasoner vessel, shallot 3g, ginger 5g, aniseed 4g, spiceleaf 3g, cassia bark 5g, the root of straight ladybell 4g, then add appropriate salt 10g, cooking wine 10g; After again boiling, add Chinese medicine additive 30g to mix thoroughly, boil half an hour with little fire, pour container into, cooling after, jelly.Do fish scale jelly water to add a little lessly, after being boiled into, add green onion, the garlic of a little choppings, after again boiling, monosodium glutamate is mixed thoroughly slightly, pours container into, cooling after, jelly.If add a little sesame oil and peanut butter before food, local flavor is better.

Detailed description of the invention 2: get 1000g fish scale, make fish scale gelation, water will add less, institute's water consumption is 1500g, uses coddle instead 1 hour after boiling, boil that fish scale bleaches, curling so that soup in the pasty state, then pull fishing squama residue out; Put into the Chinese prickly ash 8g that is contained in seasoner vessel, shallot 6g, ginger 7g, aniseed 7g, spiceleaf 8g, cassia bark 9g, the root of straight ladybell 6g, then add appropriate salt 25g, cooking wine 25g; After again boiling, add Chinese medicine additive 50g to mix thoroughly, boil half an hour with little fire, pour container into, cooling after, jelly.

China's Chinese herbal medicine resource vast in territory divides abundant, aspect development Chinese herb feed additive, there are being huge potentiality, a large amount of production practices and scientific research have also confirmed that Chinese herbal medicine has many nutritional labelings and bioactivator, as alkaloid, polysaccharide, volatile oil, boots matter, organic acid etc., have the double action of the property of medicine and trophism concurrently, both preventable disease, can improve again immunity; Not only direct bactericidal, and can regulate the immunity function of body, there is non-specific antibacterial action.Therefore abandon chemical classes additive, use the relieved Chinese medicine additive of safety, making food reach the delicious effect of safety is our consistent pursuit; The more important thing is, the advantage of Chinese herb feed additive uniqueness is to have pure natural property, from nature animal, plant and mineral matter, and its natural structure and activity are kept, long-term use and drug residue free, without the resistance to the action of a drug with have no side effect, be good Green medicament additive, also catered to the pursuit of the products of consumers in general to green non-pollution no drug residue, in food production, seem more meaningful so do additive with Chinese herbal medicine.

Analyze Chinese herbal feed additive from theory of traditional Chinese medical science and roughly have the effect of following several respects: regulate the flow of vital energy and help digestion, help spleen stomach invigorating, there is conditioning and dredge that muscle is invigorated blood circulation, the effect of food digesting stomach fortifying strengthening spleen and nourishing stomach, as the bighead atractylodes rhizome; Invigorating blood circulation addiction, vigorous circulation, enhance metabolism, have regulate channels and activate collateral, loose skin invigorates blood circulation, vigorous blood circulation, the effect such as enhance metabolism, as Radix Angelicae Sinensis, date and coix seed; Tonifying Qi establishing-Yang, nourishing the blood and yin, have qi-restoratives righting, regulates yin and yang imbalance, strengthens the effect of body antimicrbial power, as the Radix Astragali etc.; Heat reliving and toxin-eliminating, bactericidal effect, by clearing up interior heat, removing toxicity for detumescence, the subcutaneous ulcer that disappears dissipating bind and inhibition or kill bacteria be as honeysuckle; Calm the nerves arresting convulsion, the promoting the circulation of qi of having one's ideas straightened out, can tranquilizing and allaying excitement, a surname opens up the effect of key, as the seed of Oriental arborvitae.

From modern pharmacology Epidemiological Analysis taking Chinese herbal medicine effective ingredients as the additive of main body has the immunologic function that regulates body, and non-specific antibacterial action, the bioactivators such as alkaloid, polysaccharide, two class volatile oil, organic acid flavones and the bioflavonoid that Chinese herbal medicine contains anti-antibacterial composition, to regulating human body immune function, the good effect of improving health conditions.It is reported, ward off more and there is the thymus gland reaction of promotion, stimulate reticuloendothelial cell to improve specific antigen respond; Alkaloid can strengthen the phagocytic function of body fluid and cellular immune function and stimulating expression of macrophage, two classes can strengthen the phagocytic function of reticuloendothelial system, and can generate by enhancing antibody, promote antigen-antibody reaction and lymphocyte transformation organic acid can regulate the value in intestines to prevent the breeding of harmful bacteria and the activity of raising enzyme, body intracellular metabolic can normally be carried out.Divide folding Chinese herbal feed additive not only to contain the nutriment of some from the theory of modern nutriology, but also the unknown growth regulator and the pigment that contain some, there is the biochemical reaction that activates directly or indirectly body, strengthen biosynthesis effect, thereby promote the production performance of human body.

Specific embodiment 3: get motherwort 100g, RADIX POLYGONI MULTIFLORI PREPARATA 100g, bighead atractylodes rhizome 100g, date 100g, fruit of glossy privet 100g, Chinese trumpet creeper 100g, root of herbaceous peony 100g, bletilla 100g, Radix Astragali 100g, peach blossom 100g, Poria cocos 100g, reticulate millettia 100g, Radix Codonopsis 100g, mother-of-pearl 100g, Radix Angelicae Sinensis 100g, Flos Albiziae 100g, peach kernel 100g, rhizoma cyperi 100g, root of Dahurain angelica 100g, red sage root 100g, Fructus Corni 100g, coix seed 100g, Chinese yam 100g.Described bulk drug is put into after pulverizer is pulverized and crossed 120 order dusting covers, and the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves for subsequent use; Particle remaining after sieving is put into ethanol heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts are merged and left standstill; In described step c, the dregs of a decoction that above-mentioned alcohol extract is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts are merged and are left standstill.Above-mentioned two kinds of extracts are merged, and 1.38 filtrate when reduced pressure concentration relative density is 70 DEG C, reclaims ethanol, and gained filtrate is adjusted to proportion to 1.06, pass into spray dryer spray dry, the compressed air pressure of spray dryer shower nozzle be 4kg/m ², hothouse hot stream temperature is 100 DEG C, obtains raw material medicinal powder; The raw material fine powder obtaining after sieving is mixed with raw material medicinal powder and add dextrin and put into granulator and make 0.25mm～0.40mm granule.

Specific embodiment 4: get motherwort 100g, RADIX POLYGONI MULTIFLORI PREPARATA 100g, bighead atractylodes rhizome 100g, date 100g, fruit of glossy privet 100g, Chinese trumpet creeper 100g, root of herbaceous peony 100g, bletilla 100g, Radix Astragali 100g, peach blossom 100g, Poria cocos 100g, reticulate millettia 100g, Radix Codonopsis 100g, mother-of-pearl 100g, Radix Angelicae Sinensis 100g, Flos Albiziae 100g, peach kernel 100g, rhizoma cyperi 100g, root of Dahurain angelica 100g, red sage root 100g, Fructus Corni 100g, coix seed 100g, Chinese yam 100g.Chopping after mixing in proportion, puts into acid and alkali-resistance infusion kettle, at room temperature, steeps 20 days together with the above ethanol of 90 degree, and the liquid having flooded and the dregs of a decoction are carried out to squeeze and filter, gets filtrate after separation; The heating of described filtrate is concentrated into pasty state, puts into drying in oven, cooling after with grind to form fine-powdered, become pulvis.

Specific embodiment 5: when the formulation of Chinese medicine additive is paste, preparation method is: motherwort 130g, RADIX POLYGONI MULTIFLORI PREPARATA 130g, bighead atractylodes rhizome 120g, date 140g, fruit of glossy privet 120g, Chinese trumpet creeper 130g, root of herbaceous peony 1300g, bletilla 130g, Radix Astragali 120g, peach blossom 110g, Poria cocos 120g, reticulate millettia 130g, Radix Codonopsis 130g, mother-of-pearl 130g, Radix Angelicae Sinensis 130g, Flos Albiziae 140g, peach kernel 120g, rhizoma cyperi 120g, root of Dahurain angelica 130g, red sage root 130g, Fructus Corni 120g, coix seed 130g, Chinese yam 130g.Put into ethanol heating and refluxing extraction 2 times, each 1 hour, No. 2 extracts are merged and left standstill.Obtain medicinal extract; The dregs of a decoction that above-mentioned alcohol extract is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1 hour, No. 2 extracts are merged and are left standstill.Above-mentioned two kinds of extracts are merged, and reduced pressure concentration relative density is the filtrate of 1.35 (80 DEG C), reclaims ethanol, gained filtrate is adjusted to the medicinal extract of proportion to 1.06; Two kinds of medicinal extract are condensed into paste.

Various property of Chinese materia medica introductions in Chinese medicine additive:

Mother-of-pearl: flat liver, checking exuberance of yang, arresting convulsion, hemostasis.Control dizzy, tinnitus, palpitaition, insomnia, demented, frightened epilepsy, spits blood, bleeding from five sense organs or subcutaneous tissue, metrorrhagia.Mother-of-pearl with the nacre powder of Pinctada martensii to rabbit after, calcium ion concentration in blood, and gives several indifferences after calcium carbonate.Its 30% sulphuric acid hydrolysis product contains: the amino acid such as leucine, methionine, alanine, glycine, glutamic acid, asparatate, auricular concha blood vessel to rabbit and blood pressure are without effect, but can increase Isolated Toad heartbeat amplitude, reduce isolated rabbit intestines tension force, rabbit is had to of short duration diuresis.Nacre 4N hydrochloric acid extraction liquid can suppress the contraction of histamine in vitro small intestine of guinea pig.Its ether extracted liquid can suppress the contraction of histamine to intestinal tube, prevents that histamine from causing shock and the death of cavy; Though can not prevent, to internal organs allergy, as the contraction to guinea pig in vitro intestinal tube, uterus, having the tendency of inhibition to the anaphylactic shock guinea-pigs of horse serum sensitization.

RADIX POLYGONI MULTIFLORI PREPARATA RADIX POLYGONI MULTIFLORI PREPARATA be by Radix Polygoni Multiflori and black soya bean with the tuber of multiflower knotweed drying after boiling, be filling liver kidney simply, benefiting essence-blood, the good medicine that nourishes heart and allay excitement.Be mainly used in treatment and lose the diseases such as the soreness and weakness of waist and knees that causes, dizzy, palpitation and insomnia, graying of hair because of kidney deficiency and liver, essence and blood.It is to bring into play by kidney tonifying, benefit essence, the effect of allaying excitement of nourishing blood that the crow of the fleece-flower root sends out function.RADIX POLYGONI MULTIFLORI PREPARATA has enrich and benefit essence and blood, and nourishing the liver is calmed the nerves, strengthening the bones and muscles, and the crow palpus that reinforces the kidney, is shown in Light-headedness for the deficiency of blood, palpitation and insomnia is forgetful, sallow weak, the dizzy tinnitus of liver kidney blood and essence asthenia, soreness and weakness of waist and knees, the diseases such as band, poliosis are collapsed in seminal emission.

Motherwort taste is arduous, cool.Invigorate blood circulation, dispel silt, menstruation regulating, water disappears.Treatment menoxenia, threatened abortion difficult labour, placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, the carbuncle sore that swells.Motherwort is containing materials such as leonurines, fumaric acid, has the effects such as promoting blood circulation for regulating menstruation, hypotensive, inducing diuresis to reduce edema.

Fructus Corni, cures mainly perverse trend fever and chills under the heart, and Wen Zhong, by cold warm numbness, goes three worms, the merit that takes the reinforcing yin essence benefit essence of having made light of one's life by commiting suicide, five viscera settling, logical nine orifices, stops dribbling urination of a specified duration; Take for a long time improving eyesight, brute force all the year round.Fructus Corni, has another name called cornus officinalis sieb et zucc, medicine jujube, real jujube, fructus corni, meat jujube etc., is the conventional rare traditional Chinese medicine of China, and applicating history is long.It is gentle with its benefit power, establishing-Yang and do not help fire, enriching yin and oiliness diaphragm, convergence and do not stay the evil special efficacy that waits by successive dynasties use that medical science is liked.Zhang Zhongjing has been formulated " chinkuei shin chewan pills " taking Fructus Corni as monarch.According to chemical analysis, Fructus Corni contains the active ingredients such as cornin, tartaric acid, gallic acid, malic acid, resin, tannin and the multivitamin that physiologically active is stronger, having the immunity, anti-inflammatory of enhancing, the pharmacological action such as antibacterial, is the medicine simply of commonly using in tcm clinical practice.

Chinese yam is planted trace element because being rich in 18 seed amino acids and more than 10, and other mineral matter, so have strengthening the spleen and stomach, tonifying lung kidney, tonifying middle-Jiao and Qi, invigorating the spleen qi-restoratives, the effects such as beneficial essence, beneficial heart and tranquilizing mind of reinforcing the kidney, in Li Shizhen (1518-1593 A.D.) Compendium of Material Medica, there is saying of " all kinds of diseases and ailments are reinforced the kidney, controlled to invigorating the spleen help, taste essence, treats general debility ".Copper ion in Chinese yam and connective tissue have very big help to human development, vascular system disease is had to obvious curative effects, calcium in iron rod yam, the injury of the tissues is damaged to bone, osteoporosis, loss of tooth has high curative effect, pernio, diabetes, hepatitis, children's's diarrhea, enruesis, baby's indigestion, ulcerative stomatitis, pulmonary tuberculosis, the inferior patient of woman month band are also had to good curative effect, with can be clear-headed and clear-sighted, promote longevity for a long time.

Date is rich in the nutritional labeling traditional Chinese medicine theories such as protein, fat, carbohydrate, carrotene, B family vitamin, vitamin C, citrin and calcium, phosphorus, iron and CAMP to be thought, red date has the effects such as qi-restoratives benefit gas, nourishing blood and tranquilization, strengthening the spleen and stomach, is the good health nutrient fruits of patient such as weakness of the spleen and the stomach, insufficiency of vital energy and blood, lassitude, insomnia and dreamful sleep.Date tonifying middle-Jiao and Qi, nourishing blood and tranquilization.Few for insufficiency of the spleen food, weak loose stool, hysteria of womam.Energy promoting the circulation of qi, invigorates blood circulation, menstruation regulating.For irregular menstruation, red collapsing, leukorrhea, is the good merchantable brand of enriching blood.

The Radix Astragali is taking qi-restoratives as main, can invigorating qi for strengthening superficies, and diuresis holder poison, apocenosis, expelling pus and promoting granulation.For insufficiency of vital energy and blood, sore cave in, purulence becomes not burst or burst and do not hold back person for a long time.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration, i.e. the abscess suppuration myogenic of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and can strengthen the immunologic function of body, therefore can also be used for preventing the generation of some infectious disease." book on Chinese herbal medicine meets former " carries: " all void of Radix Astragali energy tonifying five zang organs, controls arteries and veins string spontaneous perspiration, rushes down yin fire, removes lung heat, losslessly sends out, and has sweat to stop." be the good medicine of promoting resistance and defence disease.

Radix Codonopsis is the conventional traditional tonic of China, and the Radix Codonopsis that produce ancient times taking area, Shangdang, Shanxi, as top grade, has tonifying middle-Jiao and Qi, effect of invigorating the spleen benefit lung.Modern study, Radix Codonopsis, containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, saponin and Alkaloid, has immunity, hemangiectasis, the step-down of enhancing, improves microcirculation, strengthens the effects such as hematopoiesis function.In addition leucocyte chemotherapy radiotherapy being caused declines castering action.Radix Codonopsis has tonifying middle-Jiao and Qi, effect of invigorating the spleen benefit lung.For a little less than the spleen deficiency syndrome of the lung, the palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst etc." new compilation of materia medica " recorded: " tonifying middle-Jiao and Qi and taste, relieving thirst and restlessness.Middle gas is faint, mends in order to adjust, very smooth and proper.”

Poria cocos taste is sweet, light, property is flat, be used as medicine there is clearing damp and promoting diuresis, the function of beneficial spleen and stomach, antitoxic heart-soothing and sedative.Modern medicine study: Poria cocos energy enhanced machine body immunity function, pachymaran has significantly antitumor and protect the liver dirty effect.Poria cocos slightly sweet flavor is flat, enters the heart, lung, the spleen channel.There is eliminating dampness and diuresis, strengthening the spleen and stomach, effect of antitoxic heart-soothing and sedative.Can control difficult urination, oedema turgor, phlegm and retained fluid is coughed contrary, vomits contrary, and vomiting during early pregnancy, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The Li Shui of Poria cocos, reaches by strong fortune spleen PFT, different from the Chinese medicine of other direct Li Shui.For splenasthenic diarrhea, the lower Poria cocos of band can invigorating the spleen, again can excreting dampness, and due to insufficiency of the spleen dysfunction of the spleen in transportation and transformation, to have loose bowels, be with down, application Poria cocos has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the bighead atractylodes rhizome, Chinese yam.Can be used as tonifying lung spleen, control the adjuvant of the deficiency of vital energy.

Coix seed is conventional Chinese medicine. be again the food of generally, often eating, property slightly sweet flavor is slightly cold, and has that inducing diuresis for removing edema, invigorating the spleen are dried, relaxing muscles and tendons is except effects such as numbness, clearing away heat and eliminating pus, is conventional damp-clearing drug.Coix seed is again a kind of beauty food, and normal food can keep human body skin gloss exquisiteness, eliminates acne, spot sparrow, senile plaque expelling, cyasma, butterfly macules, to furfur, acne, chap, pachylosis etc. has good efficacy.The kind Renhe root of the seed of Job's tears can be used as medicine and cure the disease again.Li Shizhen (1518-1593 A.D.) is recorded in Compendium of Material Medica: seed of Job's tears energy, and " invigorating spleen and reinforcing stomach, tonifying lung heat-clearing, removes wind prevailing over dampness.The food of cooking a meal, controls cold air.Decoct drink, diuresis heat is drenched." in recent years, a large amount of scientific research and clinical practices prove, the seed of Job's tears or a kind of cancer therapy drug, and Preliminary Identification, it can reach more than 35% the inhibiting rate of cancer.

Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body.Baizhu volatile oil has inhibitory action to mouse EC, lymphosarcoma ascitic type, the cancer of the esophagus (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also there is remarkable inhibitory action." property of medicine opinion " carries it: monarch, taste is sweet, pungent, nontoxic.The large wandering arthritis of energy master, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken place food that disappears, appetizing, removes sputum, removes fever and chills, under stopping, lets out.Interarea light is happy, preserves youthful looks, and de-black.The swelling of harnessing the river is full, tells to vomit contraryly, and crymodynia in abdomen, vomits and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.

Red sage root hardship, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, relieving restlessness clears away heart-fire.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest ventral spine pain, and hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass caking, sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, there is good effect through amenorrhoea pain.. " detailed outline " carries: the red sage root, and by " the sensible opinion of married woman " cloud, Siwu Tang is controlled gynecopathy, pays no attention to antenatal postpartum, how many through water, all can be general, the only taste red sage root is loose, cures mainly identical with it.Lid the red sage root can break place blood, mend new blood, peaceful tire, the stillborn foetus that falls, stop metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote liver blood circulation, is beneficial to liver cell regeneration.

Reticulate millettia property hardship, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For irregular menstruation, the deficiency of blood is sallow, paralysis and numbness, and arthralgia due to wind-dampness is activated blood and relaxed tendons; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb in every limb; Quadriplegia; Arthralgia due to wind-dampness; Chinese trumpet creeper, reticulate millettia is for oral administration is that treatment blood stasis is loose, the nourishing blood good medicine of invigorating blood circulation that becomes silted up.

Radix Angelicae Sinensis: its taste is sweet and weigh, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting circulation of blood, and bowl spares has, in row, has benefit, the really gas medicine in blood, the also panacea in blood.Approximately mending to mend of assistant, thus can support nutrition blood, tonifying Qi production of sperm, five viscera settling, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant logical to attack, therefore the pain defaecation of dispelling, relieving rigidity of muscles and joints, controls contraction, paralysis, the card such as dry, puckery.Seek void and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and table is not held back person, and assistant, with rheum officinale and so on, can be shown again admittedly.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

The pungent micro-hardship of rhizoma cyperi is sweet, and flat function cures mainly: the Xie Yu that regulates the flow of vital energy, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, indigestion, irregular menstruation, through closing dysmenorrhoea, cold hernia stomachache, swollen breasts." detailed outline " carries it: the cold epidemic disease of gas when loose, and sharp three warmers, Xie Liuyu, the diet that disappears gathers, and phlegm and retained fluid ruffian is full, and instep is swollen, abdominal distension, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, lower blood, hematuria, under married woman's uterine bleeding band, month time is uncomfortable, tire all kinds of diseases and ailments in front postpartum.

Peach kernel hardship, sweet, put down the special medicine closing for blood stasis blood.Bitter to let out stagnant blood, the new blood of Gan Yisheng." medicine justice ": peach kernel, bitter can rush down blood-head, and it is dry that body profit can be grown intestines.If it is multiplex that gross weight grinds, walk Liver Channel, the main broken blood that holds, water month by month, and pain all over, four limbs wood numbness, left hemiplegia, left sufficient patient, relaxes through the promoting circulation of blood of invigorating blood circulation with it, there is the merit of eliminate blood stasis and promote tissue regeneration, if few use is mashed in peeling, enter large intestine, controlling blood depletion just closes, blood is dry just difficult, with its make moist cool blood and blood, has out the logical stagnant power of knot.

A kind of traditional Chinese medicine material of Chinese trumpet creeper, has promoting circulation of blood and removes the stasis of blood, cooling blood, expelling wind dampness removing, and clearing heat and detoxicating, taste is sad, and cold nature is returned liver, pericardium channel, function promoting blood circulation to remove blood stasis, cooling blood, expelling wind.Cure mainly irregular menstruation, through closing swollen, the pruitus of abdominal mass, postpartum breast. " Amplification on Materia Medica addendum ": Chinese trumpet creeper, control the key medicine of pain in blood also, and tonifying yin victory is very, be stamped and keep and walk alone, in married woman side multiplex how." Nanning City's medicine will ": have the merit of eliminating inflammation and expelling toxin, hemostasis and pain-relieving, apocenosis myogenic, control red dysentery characterized by white mucous stool.

The fruit of glossy privet is secretly not clear for the order of the deficiency of liver-yin and kidney-yin, hypopsia, poliosis, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly get effect.Control order secretly not clear, often join cultivated land, mother-of-pearl is equal to use, controls poliosis, often joins the same use of mulberries, and fever due to yin deficiency, often joins the root bark of Chinese wolf-berry.The deficiency of liver-yin and kidney-yin, Light-headedness, seminal emission tinnitus, soreness and weakness of waist and knees, poliosis, coronary heart disease, hyperlipidemia, hypertension, chronic hepatitis.Protective effect research to liver is thought, the fruit of glossy privet contains oleanolic acid, give rat skin lower injection, can reduce serum glutamic pyruvic transminase, the hepatic injury of Carbon Tetrachloride Induced being had to obvious protective effect, and can promote liver cell regeneration. oleanolic acid also can make in liver triglycerides accumulate that minimizings, degeneration of liver cells necrosis obviously alleviate, glycogen is accumulated increase, the decline of serum Y globulin; Mitochondrial swelling and the sex change of endoplasmic reticulum vesica alleviates, the inflammatory reaction of hepatic tissue interstitial weakens in the visible liver cell of ultra microstructure.

Bletilla hardship, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatism and bleeding, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Shennong's Herbal: " main carbuncle swells, dislikes sore, loses subcutaneous ulcer, the dead flesh of impairment of yin, perverse trend in stomach "; Compendium of Material Medica: " smell (root) is bitter, flat, nontoxic.

Root of Dahurain angelica meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and clearing away cold, understand things pain-stopping, detumescence and apocenosis, eliminating dampness is band only." Japan hanako materia medica ": control the hot eyes triangular mass of mucous membrane growing from the inner corner of the eye, and tire patching leakage landing, broken place blood, mends new blood, acute mastitis, carbuncle on the back, scrofula, intestines wind, hemorrhoid complicated by anal fistula, and apocenosis, desolation, mange, pain relieving myogenic, goes face Shao-defect scar.

Peach blossom is the dry flower of rose family cherry peach blossom (latin name: Prunus persica).Middle unit have the medical value of dredging the channel, skin care.The beautification function of peach blossom is mainly to come from spending to contain the nutriments such as Kaempferol, perfume (or spice), beans essence, trifolin and vitamin A, B, C.These substance hemangiectasis, promotion of blood circulation, moist skin, improve blood circulation, promote skin-nourishing and oxygen supply, make to promote the lipofuscin element of human senility to accelerate excretion, prevent melanin chronic deposition in skin, thereby can effectively prevent chloasma, freckle, blackspot, in flowering peach, be also rich in vegetable protein and the amino acid that is free state, easily be absorbed by the skin, to preventing and treating dry skin, coarse and wrinkles etc. effectively, also can strengthen the resistance against diseases of skin, thereby prevent and treat skin disease, seborrhea, suppurative dermatitis, scurvy etc., of great advantage to skin.

The root of herbaceous peony enters liver, the spleen channel, nourishing blood and liver, and slow middle pain relieving, astringe yin is received sweat.Control chest abdomen pain over the hypochondriac region, rush down dysentery stomachache, spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, under band, married woman's blood closes obstructed, and the hemostasis that disappears can lose purulence, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, brings down a fever, relieving restlessness, beneficial gas, day hot disease of row, pest miasma, frightened mad, married woman's blood fortune, and intestines wind, rush down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, sore scabies, headache, improving eyesight, hot eyes is exerted meat.The many tonifying Qi of redness of the skin or complexion person, white person controls blood.

Flos Albiziae contains silk tree glucoside, tannin, and resolving stagnation for tranquilization, the appetizing of regulating the flow of vital energy, activating collaterals to relieve pain, for confused and worried, melancholy insomnia.Control pent-up uncomfortable in chest, insomnia, forgetful, acute conjunctivitis, can five viscera settling, and will, happy color, have preferably keep fit, calm, the effect of calming the nerves, improve looks, be also to treat neurasthenic good merchantable brand.Also there is clearing away summerheat, face-beautifying and spot-removing effect such as relieve the effect of alcohol." book on Chinese herbal medicine warp " said: " Flos Albiziae energy five viscera settling, and will, happy color." especially to pregnant woman, have preferably keep fit, calm, the effect of calming the nerves, improve looks, be also to treat neurasthenic good merchantable brand.

The present invention selects smell gentle, removes dampness by means of aromatics, and spot is removed in whitening, and traditional Chinese medicine ingredients promoting blood circulation and removing blood stasis does not produce Chinese medicine niff in the past, is added on and in fish scale jelly, does not affect mouthfeel, and unique flavor, allows people's aftertaste.

1, acute toxicity test

Application mouse carries out acute toxicity testing and shows: mouse oral administration gavage Chinese medicine additive paste of the present invention, under 456.8g crude drug/kg dosage, after administration, mouse occurs that light activity reduces, about 1 hour, recover normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, to take the photograph water, urine and body weight gain all normal, and experimental result shows: the maximum dosage-feeding of mouse oral administration gavage Chinese medicine additive of the present invention is 488.8g crude drug/kg/d (LD50 > 456.8g crude drug/g).Chinese medicine additive clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; Press batheroom scale, the dosis tolerata of mouse stomach Chinese medicine additive of the present invention is clinical patient 4568 times.Point out this additive totally nontoxic, clinical drug safety.

2, long term toxicity test

Select SD rat, give the Chinese medicine additive pulvis of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, after last administration, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half), and all the other 1/2 animals continue observation and live and kill after 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the changes of weight of animal, and after administration, the index checkings such as hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, Histopathology are carried out in 90 days and drug withdrawal for 2 weeks.

Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain are all without ANOMALOUS VARIATIONS; Three dosage groups and control group hematological examination, blood biochemical are learned, urine biochemical analysis is all in normal range (NR), between group without significant difference; Each group main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescence observation also has no retardance toxic reaction, points out the dosage safety of Chinese medicine additive clinical practice of the present invention higher.

3, Chinese medicine additive of the present invention is through the gastric infusion long-term toxicity test for animals result of 6 months: SD rat is divided into three groups, every group 30, male and female half and half (being divided into high, medium and low three dosage groups, 10 every group), wherein first group through gavage to physiological saline; Second group through gavage to Chinese medicine additive granule of the present invention, dosage is 0.25g, 2.5g and 12.5g/kg.d; The 3rd group is 0.5mg, 5.0mg and 50.0mg/kg.d through gavage to the dosage of Lovastatin.During administration, observe respectively the indexs such as clinical manifestation, hematology, blood biochemistry, organ coefficient and histopathology after each treated animal administration and carry out the evaluation of drug toxicity.Result of study: main toxic reaction shows Lovastatin 50mg/kg.d and 5.0mg group, shows after administration that reaction and the symptoms such as salivation, hair are fluffy, busy, diarrhoea, step have appearred in SD rat, total food ration and losing weight; Blood test shows that total white blood cells increases to some extent, red blood cell sum, content of hemoglobin and platelet count obviously decline (the equal <0.05 of P); Blood biochemistry checking shows ALT, AST, ALP and 1～8 times (equal <0.05 of P) of CK rising, and creatinine and urea nitrogen raise (the equal <0.05 of P) to some extent, but do not cause animal dead; Histopathological analysis result shows that Lovastatin 50mg/kg.d group has occurred that the liver-kidney diseases reason similar to people changes.And all there is not similar reaction in physiological saline group and Chinese medicine additive 0.25g of the present invention, 2.5g and tri-dosage groups of 12.5g/kg.d and Lovastatin 0.5mg/kg.d dosage group during whole administration, at convalescence viewing duration, the symptom of each treated animal that the occurs reaction recovery normal condition that fades away.Visible Chinese medicine additive of the present invention not only can reduce the toxic and side effect of Lovastatin, and can make the clinical non-toxic of Lovastatin be increased to 5～25 times (the equal <0.01 of P).

Chinese medicine additive pharmacodynamic experiment

Animal: experimental example mouse used is Kunming kind, is provided by Shandong Medical University's biology laboratory.

Model is built group: blank group, and granule of the present invention, Yunnan Baiyao group, Xiaoyao San, is commercially available.

1, function of promoting blood circulation to disperse blood clots

(1), the impact on clotting time of mice and plasma fibrinogen content

Clotting time of mice the results are shown in Table 1.With the comparison of blank group, the clotting time of 800mg/kg of the present invention, 1600mg/kg dosage group mouse obviously extends (P < 0.01).With the comparison of Yunnan Baiyao group, the clotting time does not have significant difference (P < 0.05).

Mice plasma fibrinogen content the results are shown in Table 2.With the comparison of blank group, 1600mg/kg dosage of the present invention has extremely significantly impact (P < 0.01) to mice plasma fibrinogen content, and other each dosage group all has no significant effect (P > 0.05).

Table 1, impact (X ± SD) on clotting time of mice

With the comparison of blank group, * P < 0.05.

Table 2, impact (X ± SD) on mice plasma fibrinogen content

With the comparison of blank group, * P=0.05; * P < 0.01.

The mensuration of 3.3 livers, the total SOD of skin, ZuCu-SOD, MDA activity

3.3.1 mensuration and the statistics of the total SOD activity of liver

Contrast with blank group, the total SOD activity value of liver of model group and low dose group of the present invention declines, and has extremely significant difference.Contrast with model group, in treatment Xiaoyao San, the present invention, dosage group has extremely significant difference.In table 3.The total SOD of mouse model liver is active to decline, and Xiaoyao San, the high, medium and low dosage of the present invention all can improve the total SOD activity of liver, and wherein in Xiaoyao San, composition, dosage group has change extremely significantly.

3.3.2 mensuration and the statistics of the total SOD activity of skin

Contrast with blank group, the total SOD activity value of skin of model group and low dose group of the present invention declines, and has significant difference; Xiaoyao San, high, the middle dosage group of the present invention and blank group are without significant difference.Contrast with model group, treatment Xiaoyao San, high, the middle dosage group of the present invention have extremely significant difference, and there were significant differences for low dose group.In table 2.The active decline of the total SOD of liver energy stagnation type mouse model skin that visible chronic constraint+ultraviolet ray+progesterone method is set up, Xiaoyao San, the high, medium and low dosage of the present invention all can improve the total SOD activity of skin, wherein Xiaoyao San, high, the middle dosage treatment of the present invention have effect extremely significantly

After treatment, there is no significant difference with blank group.

The variation (x ± s ,/mg albumen) of table 2 liver, the total SOD activity of skin

Note: dead 2 of Xiaoyao San treatment group, sample size is 8.With the comparison of blank group, * P<0.05, * * P<0.01; With model group comparison, ★ P<0.05, ★ ★ P<0.01.Liver F=4.524, skin F=5.112.

Claims (9)

1. a beauty treatment fish scale jelly, is characterized in that, described beauty treatment fish scale jelly is only made up of following raw material: fish scale, Chinese prickly ash, shallot, ginger, aniseed, spiceleaf, cassia bark, the root of straight ladybell, salt, cooking wine, Chinese medicine additive, water;

Described Chinese medicine additive is only made up of the bulk drug of following parts by weight: 10～20 parts of motherworts, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts, date, 10～20 parts of the fruit of glossy privets, 10～20 parts of Chinese trumpet creepers, 10～20 parts of the root of herbaceous peonys, 10～20 parts of bletillas, 10～20 parts of the Radixs Astragali, 10～20 parts, peach blossom, 10～20 parts, Poria cocos, 10～20 parts of reticulate millettias, 10～20 parts of Radix Codonopsis, 10～20 parts of mother-of-pearls, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Flos Albiziaes, 10～20 parts, peach kernel, 10～20 parts of rhizoma cyperis, 10～20 parts of the roots of Dahurain angelica, 10～20 parts of the reds sage root, 10～20 parts of Fructus Cornis, 10～20 parts of coix seeds, 10～20 parts of Chinese yams.

2. beauty treatment fish scale jelly according to claim 1, it is characterized in that, described Chinese medicine additive is only made up of the bulk drug of following parts by weight: 10～15 parts of motherworts, 10～15 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～15 parts of the bighead atractylodes rhizomes, 10～15 parts, date, 10～15 parts of the fruit of glossy privets, 10～15 parts of Chinese trumpet creepers, 10～15 parts of the root of herbaceous peonys, 10～15 parts of bletillas, 10～15 parts of the Radixs Astragali, 10～15 parts, peach blossom, 10～20 parts, Poria cocos, 10～20 parts of reticulate millettias, 10～20 parts of Radix Codonopsis, 10～20 parts of mother-of-pearls, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Flos Albiziaes, 10～20 parts, peach kernel, 10～20 parts of rhizoma cyperis, 10～20 parts of the roots of Dahurain angelica, 10～20 parts of the reds sage root, 10～20 parts of Fructus Cornis, 10～20 parts of coix seeds, 10～20 parts of Chinese yams.

3. beauty treatment fish scale jelly according to claim 1, it is characterized in that, described Chinese medicine additive is only made up of the bulk drug of following parts by weight: 10～20 parts of motherworts, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts, date, 10～20 parts of the fruit of glossy privets, 10～20 parts of Chinese trumpet creepers, 10～20 parts of the root of herbaceous peonys, 10～20 parts of bletillas, 10～20 parts of the Radixs Astragali, 10～20 parts, peach blossom, 10～15 parts, Poria cocos, 10～15 parts of reticulate millettias, 10～15 parts of Radix Codonopsis, 10～15 parts of mother-of-pearls, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Flos Albiziaes, 10～15 parts, peach kernel, 10～15 parts of rhizoma cyperis, 10～15 parts of the roots of Dahurain angelica, 10～15 parts of the reds sage root, 10～15 parts of Fructus Cornis, 10～15 parts of coix seeds, 10～15 parts of Chinese yams.

4. according to beauty treatment fish scale jelly described in any one in claim 1～3, it is characterized in that, described beauty treatment fish scale jelly is only made up of the raw material of following weight portion: 300～500 parts, fish scale, 3～6 parts, Chinese prickly ash, 3～6 parts, shallot, 3～6 parts, ginger, 3～6 parts of aniseed, 3～6 parts of spiceleafs, 3～6 parts, cassia bark, 3～6 parts of the root of straight ladybell, 10～20 parts of salt, 10～20 parts of cooking wine, 20～40 parts of Chinese medicine additives, 300～1000 parts, water.

5. the Chinese medicine additive using in beauty treatment fish scale jelly as described in any one in claim 2-3.

6. a preparation method for Chinese medicine additive as claimed in claim 5, is characterized in that, described Chinese medicine additive formulation is granule, and its preparation process is:

A. described bulk drug is put into pulverizer grinding and sieving,

B. particle remaining after sieving is put into ethanol heating and refluxing extraction 2 times;

C. get again the dregs of a decoction after above-mentioned alcohol extract, the heating and refluxing extraction that adds water 2 times;

D. above-mentioned two kinds of extracts are merged, decompression recycling ethanol spraying are dry, obtain medicinal powder; The fine powder that mixing sieves obtains adds dextrin and granulates.

7. preparation method according to claim 6, is characterized in that, in described step a, described bulk drug is put into after pulverizer is pulverized and is crossed 120 order dusting covers, and the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves for subsequent use; In described step b, particle remaining after sieving is put into ethanol heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts are merged and left standstill; In described step c, the dregs of a decoction that above-mentioned alcohol extract is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts are merged and are left standstill.

8. preparation method according to claim 6, it is characterized in that, in described steps d, above-mentioned two kinds of extracts are merged, 1.38 filtrate when reduced pressure concentration relative density is 70 DEG C, reclaims ethanol, and gained filtrate is adjusted to proportion to 1.06, passing into spray dryer sprays dry, the compressed air pressure of crossing spray dryer shower nozzle is 4kg/m2, and hothouse hot stream temperature is 100 DEG C, obtains raw material medicinal powder; The raw material fine powder obtaining after sieving is mixed with raw material medicinal powder and add dextrin granulation.

9. the preparation method of beauty treatment fish scale jelly as claimed in claim 4, it is characterized in that, preparation process is: the fish scale scraping, after cleaning up, put and in pot, add 1～2 times of water gaging of weight portion, after boiling, use coddle instead 1 hour, boil that fish scale bleaches, curling so that soup in the pasty state, then pull fish scale residue out; Put into the Chinese prickly ash that is contained in seasoner vessel, shallot, ginger, aniseed, spiceleaf, cassia bark, the root of straight ladybell, then with salt, cooking wine; After again boiling, add Chinese medicine additive to mix thoroughly, endure half an hour, pour container into, cooling after, jelly.