CN102784295B - Health-care preparation formula for improving female climacteric syndrome and preparation method of same - Google Patents
Health-care preparation formula for improving female climacteric syndrome and preparation method of same Download PDFInfo
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Abstract
The invention provides a health-care preparation formula for improving female climacteric syndrome and a preparation method of the health-care preparation formula. The health-care preparation formula comprises the following raw materials in part by weight: 600-1400 parts of boxthorn fruit, 600-1500 parts of rhizoma polygonati, 600-1500 parts of Indian buead, 1000-2000 parts of yam, 800-1300 parts of mulberry, 800-2000 parts of lotus seed, 800-2000 parts of arillus longan, 800-1400 parts of lily, 800-1200 parts of dried orange peel, and 1000-2000 parts of kudzuvine root. The preparation technology of the health-care preparation formula adopts a water-decocting extraction method, and the extract is separately bagged directly; and the health-care preparation formula has a simple technology, is convenient to take, and is applied to the field of female climacteric syndrome.
Description
Technical field
The invention discloses a kind of health preparation formula that improves female dimacteric syndrome and preparation method thereof.
Background technology
This age level in women 45-55 year, is medically being called climacteric.Climacteric women, because the secretion of hormone in vivo level declines, all can produce a series of variation on psychology and physiology.First be menoxenia and menolipsis, next is that dizziness and tinnitus, sleep disorder, nervous, Tidal fever with perspiration uncomfortable in chest, soreness of the waist and knees, defecation are frequent, when serious, can show as dysphoria, anxiety is melancholy, disheartened, being happy and angry uncertainly even, climacteric syndrome that Here it is.Along with the continuous progress of society, the improving constantly of people's living standard, people are also more and more higher to the prescription of life, and climacteric women, especially working woman are increasing to selecting the Chinese medicine and health food of integration of edible and medicinal herbs to improve the hope of climacteric syndrome.
Summary of the invention
The object of this invention is to provide a kind of obvious health preparation formula that improves female dimacteric syndrome and preparation method thereof.
The present invention is made by the raw material of following portions by weight: Fructus Lycii 600-1400 part, Rhizoma Polygonati 600-1500 part, Poria 600-1500 part, Rhizoma Dioscoreae 1000-2000 part, Fructus Mori 800-1300 part, Semen Nelumbinis 800-2000 part, Arillus Longan 800-2000 part, Bulbus Lilii 800-1400 part, Pericarpium Citri Reticulatae 800-1200 part, Radix Puerariae 1000-2000 part.
Good weight proportion of the present invention is: Fructus Lycii 700-1300 part, Rhizoma Polygonati 700-1400 part, Poria 700-1400 part, Rhizoma Dioscoreae 1200-1800 part, Fructus Mori 900-1200 part, Semen Nelumbinis 1000-1800 part, Arillus Longan 1000-1800 part, Bulbus Lilii 900-1300 part, Pericarpium Citri Reticulatae 900-1100 part, Radix Puerariae 1200-1800 part.
The optimum weight proportioning of each composition is above: 1000 parts of Fructus Lycii, 1000 parts of Rhizoma Polygonatis, 1000 parts, Poria, 1500 parts of Rhizoma Dioscoreaes, 1000 parts of Fructus Mori, 1500 parts, Semen Nelumbinis, 1500 parts of Arillus Longans, 1200 parts of Bulbus Liliies, 1000 parts of Pericarpium Citri Reticulataes, 1500 parts of Radix Puerariaes.
Preparation method of the present invention comprises the following steps:
(1) each medical material in formula is placed in to boil carries pot, infiltrate 30 minutes, then add the deionized water of 10 times of amounts, 2 hours post-heating of soaking at room temperature, to boiling, boil and extract 2 hours, and the water outlet extract that inclines, filters.
(2) again add the deionized water of 10 times of amounts of medical material, boil and extract 2 hours, the water outlet extract that inclines, filters.
(3) combining step (1), (2) gained filtrate, be cooled to room temperature, and centrifugal 30 minutes, discard precipitation, collect supernatant.
(4) filtrate of step (3) gained being concentrated into medicinal liquid ratio is 1: 2 (60 ℃), adds natural absorptive clarificant (Beijing Zheng Tiancheng clarification technique company limited), centrifugal 30 minutes, discard precipitation, and collect supernatant;
(5) by the supernatant concentration of step (4) gained to relative density>=1.27gm1
-1(60 ℃), dry, pulverize, and are distributed into the fractional pack of 10 grams.
Formula of the present invention forms rationally, and preparation process science, carries and instant.Climacteric be each women must through period, due to physiological variation, cause the decline of body function, and Chinese medicine just can to bring into play the advantage of preventive treatment of disease be that involutional women escorts.Female dimacteric syndrome can be alleviated and improve to long-term invented food.
Analysis of drug use:
Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..
[property of medicine] is sweet, flat.Return liver, kidney channel.
[effect] nourishing the liver and kidney, replenishing vital essence to improve eyesight.
Visual deterioration, the cataract blurred vision of [application] treatment due to asthenia of essence and blood, have a dizzy spell, soreness of the waist and knees, seminal emission lingering diarrhea, deafness, odontoseisis, early whitening of beard and hair, insomnia and dreamful sleep and the hepatic and renal YIN deficiency, hectic fever night sweat, the card such as quench one's thirst.
< < Sheng Nong's herbal classic > > claims Fructus Lycii " to take for a long time hard muscles and bones, make light of one's life by commiting suicide not old, cold-resistant summer-heat ".
< < book on Chinese herbal medicine converges speech > > and praises it " gas can be filled, and blood can be mended, Yang Kesheng, the moon can be grown ".
< < Compendium of Materia Medica > > records: " Fructus Lycii, kidney-tonifying sperm-generating, nourishing the liver, improving eyesight, hard smart bone, fatigue taking away, easily color, bleaches, and improving eyesight is calmed the nerves, and makes us long-lived.”
Modern medicine study confirms that it contains the nutritional labelings such as betaine, polysaccharide, crude fat, crude protein, carotene, vitamin A, vitamin C, vitamin B1, vitamin B2 and calcium, phosphorus, ferrum, zinc, manganese, linoleic acid, modern medicine study proves: Fructus Lycii has facilitation to immunity, has immunoregulation effect simultaneously; Can improve plasma testosterone level, play strong effect; Hemopoietic function is had to facilitation; Normal healthy people is also had to remarkable effect in increasing leukocyte; Also have antioxidation, defying age, resisting fatigue, mutation, antitumor, blood fat reducing, protect the liver and anti-fatty liver, blood sugar lowering, blood pressure lowering, the kidney invigorating, improving eyesight, skin care, brain-strengthening, toxin expelling, protection reproductive system, 16 functions of Antiradiation injury.
Rhizoma Polygonati is the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati (Polygonatum kingianum Coll.et Hemsl.), Rhizoma Polygonati (Polygonatum sibiricum Red.) or Polygonatum cyrtonema Hua (Polygonatum cyrtonema Hua.).
[property of medicine] is sweet, flat.Return spleen, lung, kidney channel.
[effect] boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.
The few expectorant of dry cough, the chronic cough chronic cough of YIN-deficiency of the lung and kidney, weakness of the spleen and stomach, fatigue and asthenia, inappetence, the xerostomia lack of appetite of [application] treatment lung gold impairment of both QI and YIN, can slow down aging, improves dizziness, soreness of the waist and knees, early whitening of beard and hair, asthenia of essence and blood, the interior-heat disease such as quench one's thirst.
< < Compendium of Materia Medica > >: " mend all void, stop cold and heat, replenishing essence marrow.”
< < Japan hanako materia medica > >: " mend five kinds of strain and seven kinds of impairment, help muscles and bones, granulation promoting, cold-resistant summer-heat, strengthening the spleen stomach, profit cardiopulmonary ".
Modern pharmacology experiment shows: Rhizoma Polygonati rhizome contains Yan acid, phlegmatic temperament, quinones, and containing polygonatum polysaccharide first, second, the third, polygonatum rhizome oligosaccharide first, second, the third, polysaccharide first, second, third is combined into by glucose, mannose, galacturonic acid; Oligosaccharide first, second, third is combined into by glucose and fructose, separately containing 11 seed amino acids such as lysines.Can improve body's immunity and promote the synthetic of DNA, RNA and protein, promote lymphocyte transformation effect; There is significant anti-mycobacterium tuberculosis effect; Multiple pathogenic fungus is had to inhibitory action; Bacillus typhi, staphylococcus aureus are also had to inhibitory action; Have and increase coronary flow and hypotensive effect, and can blood fat reducing and alleviate Coronary Artery Atherosclerosis; Blood glucose that epinephrine is caused is too high is remarkable inhibitory action; Suppress in addition adrenocortical effect and delaying senility function; Polygonatum polysaccharide has Immunestimulatory effect.
Poria is the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.
[nature and flavor] are sweet, light, flat.GUIXIN, lung, spleen, kidney channel.
[effect] promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.
[application] for edema oliguria, phlegm retention vertigo and palpitation, and insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
< < Japan hanako materia medica > >: " mend five kinds of strain and seven kinds of impairment, antiabortive, warm waist knee joint, happy Fructus Alpiniae Oxyphyllae, only forgetful.”
< < medication heart method > >: " sweet with supporing yang, the panacea of dehumidifying also for Poria, the sharp key of light energy.The flat YANG invigorating of sweet in the mouth, strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation, the inducing QI of promoting the production of body fluid.”
Modern pharmacology experiment shows:: Poria energy enhancing human body immunity function, pachyman has the function of anti-atrophy of thymus gland and anti-splenomegaly and tumor suppression growth, pachyman gavage can strengthen macrophage phagocytosis of mice, increase ANAE positive lymphocyte number, can also make mouse spleen antibody secreting cell count showed increased. pachyman also can make the caused rat leukopenia of cyclophosphamide accelerate. and carboxymethyl pachyman also has immunomodulating, the liver protecting and ALT lowering, indirect antiviral, induce and short inducement interferon, alleviate radiation side reaction, induce and urge to induce the multiple physiologically actives such as leukoregulin.
Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposite Thumb..
[nature and flavor] are sweet, flat.Return lung, spleen, kidney channel.
[effect] spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.
[application] Rhizoma Dioscoreae sweet in the mouth is flat, and effect relaxes, cold not hot, can QI invigorating, again can yin nourishing, and tonify without causing stagnation, grows and oiliness.It is the good merchantable brand of flat tonifying the lung spleen kidney.Be used for becoming thin weak, lack of appetite, loose stool person, as < < Compendium of Materia Medica > > cloud: " kidney tonifying gas, strengthening the spleen and stomach." because of it, contain more nutritional labeling; easily digest and assimilate again; can be used as food life-time service; < < Sheng Nong's herbal classic > > cloud its " invigorating middle warmer, physical strength profiting, longue meat "; therefore for chronic disease or weak after being ill; need nutrition to adjust to mend and dysfunction of the spleen person is good merchantable brand, as Semen Coicis yam porridge.
Modern pharmacology experiment shows: the main component of Rhizoma Dioscoreae is amylase, can move in stimulating gastrointestinal road, promote that enteral thing is emptying, increase Small Intestinal, contribute to digestion, blood pressure lowering, blood sugar lowering, the purification starch of prevention and cure of cardiovascular disease Rhizoma Dioscoreae can reduce lipid concn, reduces the sugared concentration of aorta and heart and the concentration of cholesterol simultaneously.Improve immunity, defying age Rhizoma Dioscoreae is rich in polysaccharide, can stimulate and regulate immune system, can increase blood leucocyte content, strengthen leukocytic phagocytosis, so Rhizoma Dioscoreae can be used as the health care medicinal that people increase immunocompetence.In Rhizoma Dioscoreae, contain the effective ingredient such as protein (comprising 16 seed amino acids that needed by human body is wanted), saccharide, vitamins, there is the effect of good slow down aging, significant prolongation life, often edible Rhizoma Dioscoreae, good for health.Improve immunity, defying age Rhizoma Dioscoreae is rich in polysaccharide, can stimulate and regulate immune system, can increase blood leucocyte content, strengthen leukocytic phagocytosis, so Rhizoma Dioscoreae can be used as the health care medicinal that people increase immunocompetence.
Fructus Mori is the dry fruit ear of moraceae plants Mulberry Morus alba L..
[nature and flavor] are sweet, sour, cold.Return liver, kidney channel.
[effect] nourishing YIN and supplementing blood, promotes the production of body fluid and moisturizes.
[application] is applicable to that vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound are thirsty, interior-heat is quenched one's thirst, blood deficiency and constipation, order are dark, tinnitus, scrofula, articular instability.
< < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " kidney tonifying is dirty and controlling nocturnal emission with astringent drugs takes hair color improving eyesight for a long time.”
< < is with ceasing living in seclusion recipe > >: " wind-damp dispelling, walks with vigorous strides to carry out, breath wind syndrome caused by deficiency, clearly asthenic fire for nourish liver and kidney, enrich blood.”
< < Bencao Shiyi > >: " sharp the five internal organs joint, logical vim and vigour.Clothes are not hungry for a long time, and spirit sedation, makes us clever, bleaches not old.”
Modern medicine study confirms: it is sugary, the acid of mixing, malic acid and vitamin B1, B2, C and carotene.The fatty acid of Fructus Mori oil is mainly comprised of the stearic acid of linoleic acid and amount, oleic acid etc.Be improved skin (comprising scalp) blood supply, nutrition skin, makes the effects such as the delicate and black hair of skin, and can slow down aging.Be healthy and strong U.S. face, antidotal good fruit and good medicine.Normal food Fructus Mori can improving eyesight, the symptom that relieving eye strain is dry and astringent.Fructus Mori have immunologic enhancement.Fructus Mori have effect of gain to spleen, and to hemolytic, reaction has potentiation, can prevent human body artery sclerosis, skeleton arthrosclerosis, enhance metabolism.It can promote the growth of erythrocyte, prevents leukopenia, and the diseases such as treatment diabetes, anemia, hypertension, hyperlipidemia, coronary heart disease, neurasthenia are had to auxiliary effect.Proper amount of edible can promote gastric secretion, stimulates enterokinesia and removes scorching.
Semen Nelumbinis are the dry mature seed of nymphaeaceae plant lotus Nelumbo nucifera Gaertn..
[nature and flavor] are sweet, puckery, flat.Return spleen, kidney, heart channel.
[effect] spleen reinforcing antidiarrheal, leukorrhagia stopping, kidney tonifying arresting seminal emission, tranquilizing by nourishing the heart.
[application], for diarrhea due to hypofunction of the spleen, leukorrhagia, passes out semen, palpitation and insomnia.
< < Sheng Nong's herbal classic > >: " main invigorating middle warmer, repose, physical strength profiting.”
< < Compendium of Materia Medica > >: " kidney of laying one's heart bear, thick the intestines and stomach, controlling nocturnal emission with astringent drugs gas, bone and muscle strengthening; tonifying deficiency, sharp knowledge, eliminating cold-damp; stop the splenic diarrhea chronic dysentery, reddish and whitish turbid urine, all disorders of blood of woman's leukorrhagia metrorrhagia.”
< < Japan hanako materia medica > >: " QI invigorating, quenches the thirst, and helps the heart, dysentery relieving.Control lumbago, let out essence.”
Modern medicine study confirms: Semen Nelumbinis have calmness, heart tonifying, the anti-ageing multiple effect of waiting for a long time.Nutritious lotus seed is very abundant, except containing much starch, also contains cupreol, the minerals and vitamins such as alkaloid and abundant calcium, phosphorus, ferrum.
Arillus Longan is the aril of sapindaceous plant Arillus Longan Dimocarpus longan Lour..
[nature and flavor] are sweet, temperature.GUIXIN, spleen channel.
[effect] invigorating the heart and spleen, nourishing blood to tranquillize the mind.
[application] for insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.
< < must join herbal > >: " strengthening the spleen stomach, preserves painstaking effort, and moistening five ZANG-organs, controls palpitation with a distress feeling.”
< < day is with herbal > >: " Fructus Alpiniae Oxyphyllae mind calming.”
Modern medicine study confirms: Arillus Longan is eaten raw; taste is sweet tasty and refreshing; and nutritive value is very high; be rich in Hi CHO, protein, several amino acids and vitamin B, C, calcium, phosphorus, ferrum, tartaric acid, gland fat purine etc.; wherein especially with many containing Citrin amount; for middle-aged and elderly people, there is the effect of protecting blood vessel, preventing sclerosis of blood vessels and fragility.To with aging course have substantial connection flavoprotein---brain monoamine oxidase B (MAO-B) has stronger inhibitory action.Because of iron content and vitamin B2 very abundant, can alleviate uterine contraction and the sagging sense of palace body.
Bulbus Lilii is the dry meat scale leaf of liliaceous plant tiger lily Lilium lancifoliumn Thunb., Bulbus Lilii Lilium brownii F.E.Brown var.viridulum Baker or Lilium tenuifolium Lilium pumilum DC..
[nature and flavor] are sweet, cold.GUIXIN, lung meridian.
[effect] nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.
[application] for deficiency of YIN cough caused by dryness, chronic cough hemoptysis, fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep, absentminded.
< < Japan hanako materia medica > >: feel at ease, determine gallbladder, beneficial will, supports five and hide, control insane heresy, weep, mad crying, palpitation with fear, kill diseases due to noxious agents produced by various parasites gas, carbuncle in the hypochondriac region acute mastitis carbuncle on the back and all skin ulcers are swollen, and the mad fortune of blood after managing property.
The lilii and Anemarrhenae Decoction of recording in < < Medical Treasures of the Golden Chamber > > has estrogenic activity effect, and the party is used for the treatment of perimenopausal syndrome.
Modern pharmacological research shows: Bulbus Lilii is containing multiple alkaloid and starch, protein, fat, starch, calcium, phosphorus, ferrum and vitamin Bs such as colchicine
1, vitamin B
2, vitamin C etc.The flower pesticide of Lilium longiflorum contains multiple types carotene, and wherein major part is along antheraxanthin ester (Cis-Antheraxanthin esters), accounts for 91.7%～94%.Research shows: the Lipid composition of medicine Bulbus Lilii, lanzhou lily, Lilium longiflorum be take the content of cardiolipin and phosphorus fatty acid as main.
Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange Citrus reticulata Blanco. and variety thereof.
[nature and flavor] are bitter, pungent, temperature.Return lung, spleen channel.
[effect] regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
[application] for distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.
< < Compendium of Materia Medica > >: " it controls all kinds of diseases and ailments, always gets the merit of its dampness of regulating the flow of vital energy, and mends with tonic, rushes down with cathartic, rises with Hydrargyri Oxydum Rubrum, falls with falling medicine.Spleen is the mother of vigour, and lung is to take the photograph wanting of gas, therefore Pericarpium Citri tangerinae is two medicines through edema caused by disorder of QI, but with join and reinforcing and reducing lifting also.”
< < day is with herbal > >: " can fall apart and can rush down, can temperature can mend, the diaphragm gas that can disappear, the saliva that reduces phlegm, and spleen antitussive, lead to five types of stranguria.”
< < book on Chinese herbal medicine converges says > >: " acrid in the mouth is kind loose, therefore can open gas; The bitter using pungent drugs for dispersion and bitter drugs for purgation of stomach, therefore can manage it expectorant; Its temperature is flat, be good at sensible, therefore can preventing or arresting vomiting, cough-relieving, invigorating the spleen and regulating the stomach person is also.Dong Yuan says: madam be take taste as main, and cure the disease, take regulating QI as first, and as wanted regulating QI spleen invigorating person, here the merit of Pericarpium Citri tangerinae occupies its head.”
Modern pharmacological research shows: Pericarpium Citri Reticulatae contains volatile oil 1.5% (milling process) to 2% (way of distillation), in oil, main component is D-limonene, also containing beta-myrcene α-and nopinene etc., separately containing flavones ingredient hesperidin, neohesperidin, naringenin, dihydro Nobiletin and the nor-dihydro Nobiletin of 5-; Report that again river Pericarpium Citri Reticulatae is containing hesperidin approximately 8.4%, Nobiletin approximately 0.15%.Another containing Neosynephrine (oxedrine) 0.28%-2.54%.Pericarpium Citri Reticulatae extract can be removed superoxide anion (O-) and the hydroxy radical (OH) that hypoxanthine-xanthine oxidase system produces, and can suppress the mouse cardiac muscle homogenate that oxygen-derived free radicals induces and organize lipid peroxidation.Hesperidin has the ability of strong Scavenger of ROS and has the effect that reduces activity of myeloperoxidase.In Pericarpium Citri Reticulatae, contained polymethoxyflavone can suppress the growth of MCF-7 Human Breast Cancer Cells strain.Nobiletin can be induced Non-small Cell Lung Cancer A 549 apoptosis.It is remarkable that clinical research shows, with Pericarpium Citri Reticulatae injection, paroxysmal tachycardia patient is turned to rule therapeutical effect at once, without obvious adverse reaction.
Radix Puerariae is the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi.
[nature and flavor] are sweet, pungent, cool.Return spleen, stomach, lung meridian.
[effect] expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, yang invigorating antidiarrheal, dredge the meridian passage, alcoholic intoxication.
[application] has a headache for fever caused by exogenous pathogens, and stiff nape and back is thirsty, quench one's thirst, and measles without adequate eruption, hematodiarrhoea, has loose bowels, dizziness and headache, apoplectic hemiplegia, obstruction of qi in the chest and cardialgia, damage of the spleen and stomach caused by alcoholism.
< < Compendium of Materia Medica > >: " Radix Puerariae, cool in nature, gas is put down, sweet in the mouth, tool heat clearing away, pathogenic fire reducing, all effects of toxin expelling.”
The just > > of < < book on Chinese herbal medicine: " can develop the gas of the clear sun of taste.”
Modern pharmacological research shows: the main carbohydrate containing of Radix Puerariae, vegetable protein, multivitamin, aminoacid and mineral, contain in addition Flavonoid substances: Dai, daidzin, also has Dai-4,7-diglucoside, puerarin, puerarin-7-xyloside, Radix Puerariae alcohol, Radix Puerariae rattan and daidzin etc.Isoflavonoid puerarin in Radix Puerariae has certain curative effect to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.The flavone proposing in Radix Puerariae can increase brain and crown vascular flow amount.Find that after deliberation the content of isoflavone in Herba Gelsemii Elegantis often eats the skin care of Herba Gelsemii Elegantis food energy looks with active far above in Semen sojae atricolor, promote whitening skin, smoothness, exquisiteness, make women's brilliance that radiates the vigour of youth, climacteric syndrome is had to opsonic action simultaneously.With age, health reduces the absorption of calcium, and calcium reduces, and skeleton decalcification, osteoporosis easily occurs, and often edible Herba Gelsemii Elegantis goods can prevention of osteoporosis.
Clinical trial:
The traditional Chinese medical science thinks that climacteric syndrome is the year that women is broken a warp, congenital kidney qi degradation, and conception vessel is empty, and taichong channel declines, and menses will exhaust, and cause body imbalance of YIN and YANG, or deficiency of kidney yin, and sun loses hiding; Or kidney yang deficiency, passages through which vital energy circulates loses the disease that occurs a series of function disorders in replenishing vital QI with drugs of warm nature.Below by this product treatment climacteric syndrome 50 examples, the effect of climacteric syndrome is improved and treated to checking this product.
[clinical data]
Observe 50 routine patients, be outpatient clinic female patient, the age, the course of disease was less than 6 months person's 26 examples at 45～55 years old, 6 months to 2 years person's 12 examples, 2 years above person's 12 examples.Diagnostic criteria is: the 1. women at 45～55 years old age, and except menoxenia, hectic fever sweating is typical specific symptom, can be with irritated irritability, palpitation and insomnia, headache uncomfortable in chest, abnormal emotion-thought, hypomnesis, fluctuation of blood pressure, waist and leg ache etc.2. the endocrine indexes relevant to primary disease measured: estradiol (E2) reduces, and follicle stimulating hormone (FSH), lutropin (LH) increase.3. should get rid of psychotic, hyperthyroidism, the serious primary disease patient of liver, kidney and hemopoietic system.
[Therapeutic Method]
Diet still, takes 1 bag of this product every day three after the meal, 3 bags of every days, takes continuously 60 days.
[therapeutic outcome]
1, criterion of therapeutical effect: with reference to the curative effect determinate standard of climacteric syndrome in < < new Chinese medicine guideline of clinical investigations > >.
Recovery from illness: clinical symptom disappearance, physico-chemical examination result is recovered respective horizontal;
Effective: symptom is clearly better, physico-chemical examination result is recovered respective horizontal substantially;
Effective: symptom takes a turn for the better to some extent, physico-chemical examination result makes moderate progress;
Invalid: symptom, sign, physical and chemical index all do not take a turn for the better or worsen.
2, result: recovery from illness 5 examples, effective 15 examples, effective 18 examples, invalid 12 examples, cure rate: 10%; Total effective rate: 76%.
[model case]
Health, female, 50 years old, December in 2009 first visit on the 3rd.There is menoxenia, hectic fever sweating symptom and with irritated irritability, palpitation and insomnia, the symptoms such as hypomnesis, the few tongue of red tongue, thready pulse.Through various inspections, do not find organic disease, be diagnosed as " climacteric syndrome ".Tcm diagnosis is " pre-postmenstrual syndromes ", and dialectical is kidney qi virtual loss, imbalance of YIN and YANG.The bimester of taking this product, 3 bags of every days.Further consultation, the bimester that patient's private prosecution taking this product after many symptoms obviously improve or disappear.
The specific embodiment
The preparation of embodiment 1 extract and product
By optimum weight proportioning, take 1000 parts of Fructus Lycii, 1000 parts of Rhizoma Polygonatis, 1000 parts, Poria, 1500 parts of Rhizoma Dioscoreaes, 1000 parts of Fructus Mori, 1500 parts, Semen Nelumbinis, 1500 parts of Arillus Longans, 1200 parts of Bulbus Liliies, 1000 parts of Pericarpium Citri Reticulataes, 1500 parts of Radix Puerariaes.Adding 10 times of amount deionization decocting in water carries 2 times, each 2 hours, leach cooking liquid filtration, centrifugal (3000 revs/min) 30 minutes, get supernatant, be concentrated into medicinal liquid than 1: 2 (60 ℃), after add natural absorptive clarificant (4% clarifier A, 8% clarifier B), then centrifugal (3000 revs/min) 30 minutes, get the 1.27gml that supernatant continues to be concentrated into relative density
-1after (60 ℃), belt drying, is ground into fine powder, is distributed into the fractional pack of 10 grams of left and right.
Embodiment 2 product treatment climacteric syndromes
Climacteric syndrome is the series of symptoms being caused by decrease in estrogen.Climacteric women, due to hypo-ovaria, hyperpituitarism, the promoting sexual gland hormone of supersecretion, cause autonomic nervous dysfunction, thereby occur the symptom that a series of degree are different, as menstruation variation, flushed face, cardiopalmus, insomnia, weak, depressed, worry too much, emotional instability, emotional, attention is difficult to concentrate etc.This product can make these symptoms improve or disappear.
Clinical data
Treatment number: 20 people; Age: 45～55; The medicine time of appearance effect and number: 8 weeks 12 people, 9 weeks 6 people, 10 weeks 2 people.Efficiently individual quantity: 18 people.DeGrain number: 2 people.
Case report
Recklessly * *, female, 49 years old.Within nearly 2 years, sensation health is tired, and energy is poor, irritated irritability, palpitation and insomnia, hypomnesis, the discomforts such as waist and leg ache.Take this product after 8 weeks, energy and muscle power are obviously improved, and are emotionally stable, and sleep quality improves, and involutional malaise symptoms is obviously alleviated.Owing to adhering to long-term taking this product, Mrs Hu has rosy cheeks now, full of vigor, and sensation is own young many.
Claims (5)
1. improve a health preparation for female dimacteric syndrome, it is characterized in that raw material used and parts by weight thereof: Fructus Lycii 600-1400 part, Rhizoma Polygonati 600-1500 part, Poria 600-1500 part, Rhizoma Dioscoreae 1000-2000 part, Fructus Mori 800-1300 part, Semen Nelumbinis 800-2000 part, Arillus Longan 800-2000 part, Bulbus Lilii 800-1400 part, Pericarpium Citri Reticulatae 800-1200 part, Radix Puerariae 1000-2000 part.
2. the health preparation that improves female dimacteric syndrome according to claim 1, is characterized in that raw material used and parts by weight thereof: Fructus Lycii 700-1300 part, Rhizoma Polygonati 700-1400 part, Poria 700-1400 part, Rhizoma Dioscoreae 1200-1800 part, Fructus Mori 900-1200 part, Semen Nelumbinis 1000-1800 part, Arillus Longan 1000-1800 part, Bulbus Lilii 900-1300 part, Pericarpium Citri Reticulatae 900-1100 part, Radix Puerariae 1200-1800 part.
3. the health preparation that improves female dimacteric syndrome according to claim 1, is characterized in that raw material used and parts by weight thereof: 1000 parts of Fructus Lycii, 1000 parts of Rhizoma Polygonatis, 1000 parts, Poria, 1500 parts of Rhizoma Dioscoreaes, 1000 parts of Fructus Mori, 1500 parts, Semen Nelumbinis, 1500 parts of Arillus Longans, 1200 parts of Bulbus Liliies, 1000 parts of Pericarpium Citri Reticulataes, 1500 parts of Radix Puerariaes.
4. according to the health preparation preparation method of improving female dimacteric syndrome described in claim 1,2 or 3, it is characterized in that preparation process carries out according to the following steps:
(1) each medical material in formula is placed in to boil carries pot, infiltrate 30 minutes, then add the deionized water of 10 times of amounts, soaking at room temperature 2 hours; Then be heated to boiling, boil and extract 2 hours, the water outlet extract that inclines, filters;
(2) again add the deionized water of 10 times of amounts of medical material, boil and extract 2 hours, the water outlet extract that inclines, filters;
(3) combining step (1), (2) gained filtrate, cooling, centrifugal, discards precipitation, collects supernatant;
(4) filtrate of step (3) gained is concentrated, add natural absorptive clarificant, discard precipitation, collect supernatant;
(5) by the supernatant concentration of step (4) gained, dry, pulverize, be distributed into the fractional pack of 10 grams.
5. according to the health preparation that improves female dimacteric syndrome described in claim 1,2 or 3, it is characterized in that: for female dimacteric syndrome, effectively alleviate the symptom of female menstrual disorder, irritated irritability, palpitation and insomnia, headache uncomfortable in chest, hypomnesis, fluctuation of blood pressure, waist and leg ache.
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| CN103859369A (en) * | 2012-12-10 | 2014-06-18 | 天津红日药业股份有限公司 | Health-preserving health food formula beneficial for beautifying and enlarging breasts and preparation method thereof |
| CN103859373A (en) * | 2012-12-10 | 2014-06-18 | 天津红日药业股份有限公司 | Formula and preparation method of life cultivation and health preservation food helpful for preserving health during menstrual period |
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| CN104012951A (en) * | 2013-12-17 | 2014-09-03 | 胡安然 | Diet for delaying female climacterium |
| CN105011130A (en) * | 2014-04-29 | 2015-11-04 | 赛珂睿德生物医药科技(上海)有限公司 | Functional food for improving climacteric syndrome |
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| CN109172730A (en) * | 2018-08-31 | 2019-01-11 | 江苏康缘药业股份有限公司 | A kind of composition and the preparation method and application thereof with improvement climacteric syndrome function |
| CN111329953A (en) * | 2020-04-27 | 2020-06-26 | 付华松 | Traditional Chinese medicine composition for treating climacteric syndrome and preparation method thereof |
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| CN115590140A (en) * | 2021-06-28 | 2023-01-13 | 江苏京森生物医药新材料科技有限公司（Cn） | Health-care functional food for regulating female endocrine balance and relieving climacteric syndrome and irregular menstruation |
| CN114343179A (en) * | 2022-01-24 | 2022-04-15 | 中禾宝桑生物科技有限公司 | Mulberry oral liquid for aiding sleep and beautifying and preparation method thereof |
| KR102497345B1 (en) * | 2022-10-20 | 2023-02-06 | 재단법인 자생의료재단 | Composition for preventing or Treating female climacteric syndrome comprising complex extract of Polygonatum and Nelumbinis Semen |
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