CN109172730A - A kind of composition and the preparation method and application thereof with improvement climacteric syndrome function - Google Patents
A kind of composition and the preparation method and application thereof with improvement climacteric syndrome function Download PDFInfo
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- CN109172730A CN109172730A CN201811014790.3A CN201811014790A CN109172730A CN 109172730 A CN109172730 A CN 109172730A CN 201811014790 A CN201811014790 A CN 201811014790A CN 109172730 A CN109172730 A CN 109172730A
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Classifications
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention proposes a kind of with the composition for improving climacteric syndrome, which is characterized in that the composition is made by the raw material of following parts by weight: jujube: 1-15 parts, Poria cocos: and 1-15 parts, raspberry: 1-10 parts, lily: 1-10 parts, lotus seeds: 1-6 parts.The present composition is the common food materials of dual-purpose of drug and food, is easily received, and can be reduced the rejection feeling that user psychologically generates, and increases edible comfort, and it can not only cook health food long-term use, but also the good medicine that can cure the disease.In addition, the solid beverage that the present composition is made into brews rear liquid clarification, special taste, it is conducive to consumer and receives.The composition proves there is remarkable result to rat climacteric syndrome is improved through effect experiment.
Description
Technical field
The present invention relates to drug, health care product and food technology fields, more particularly to one kind to have improvement climacteric syndrome
Health-care food composition of function and preparation method thereof.
Background technique
Climacteric is the ovarian function of women from healthy state fall off, until the transition that its function completely loses
Stage, during this period, women can generate the variation for various physiology and psychological aspects occur, this can seriously affect the body and mind of women
Health and Living quality.Climacteric syndrome refers to that women leads to vegetative nerve functional disturbance, life since sex hormone secretion is reduced
Grow a series of syndromes based on system atrophy with mental symptoms.
Currently, national Menopause number about as many as 1.3 hundred million, accounts for about the 20% of female population, wherein more than 80% meeting
There is climacteric syndrome performance.Climacteric cardinal symptom shows as decrease of memory, mood agitation, sleep bad, night sweat, dreaminess
Deng.
For in the product for the treatment of and improvement Menopause, existing prescription medicine, non-prescribed medicine also have health food.From
Commercially available product situation is analyzed, and prescription medicine is mainly used for controlling for the patient with serious menopause symptom and early ageing women
It treats.There are two main classes for non-prescribed medicine: one kind is tradition conditioning class, is more likely to daily health caring；Another kind of is modern health class,
Based on being mainly formulated with traditional Chinese medicine.Healthcare food mostly with natural plants estrogen (soybean, pueraria lobata etc.) be primary raw material, with
Based on " increasing bone density " etc..
Summary of the invention
The invention is intended to provide a kind of drug, food or health care product that can improve climacteric syndrome.Specifically,
The invention proposes a kind of with the composition for improving climacteric syndrome, which is characterized in that the composition is pressed
The raw material of column parts by weight is made: jujube: 1-15 parts, Poria cocos: and 1-15 parts, raspberry: 1-10 parts, lily: 1-10 parts, lotus seeds: 1-6
Part.Wherein, improve climacteric syndrome and refer to energy complementing estrogen, nourish the functions such as ovary or nourishing yin to moisten dryness, alleviate
The symptoms such as mood agitation, insomnia and dreamful sleep, night sweat.
Further, the composition is made by the raw material of following parts by weight: jujube: 3-12 parts, Poria cocos: 2-12 parts, covering basin
Son: 1.5-8 parts, lily: 1.5-8 parts, lotus seeds: 0.5-4 parts.
Preferably, the composition is made by the raw material of following parts by weight: jujube: 10-12 parts, Poria cocos: 9-11 parts, covering basin
Son: 5-7 parts, lily: 5-7 parts, lotus seeds: 1-2 parts.More preferably, jujube: 12 parts, Poria cocos: 10 parts, raspberry: 6 parts, lily: 6
Part, lotus seeds: 2 parts.
Wherein, composition of the invention can directly pulverize, and be also possible to by extract made from conventional means
Or other forms etc..
The invention also provides any of the above-described compositions to have drug, food or the guarantor for improving climacteric syndrome in preparation
Application in strong product.
The invention also provides a kind of food or health care products, which is characterized in that the food or health care product are by claim 1-3
Acceptable auxiliary material or additive are made on described in any item compositions and food.
Preferably, the food or health care product are selected from solid beverage.
The invention also provides the preparation methods of aforementioned food or health care product, which comprises the following steps:
(1) jujube, Poria cocos, raspberry, lily and lotus seeds medicinal material are taken, impurity is removed, is cleaned；Medicinal material total amount 8- is added every time
The water of 12 times of amounts heating extraction 2 times, filters, merging filtrate, and filtrate is concentrated into the concentrate that relative density is 1.05~1.10,
Add auxiliary material, is spray-dried, obtains spray powder, it is spare.
(2) spray powder in (1) is taken, auxiliary material and sweetener is added, is mixed, granulation is packed to get solid beverage.
Specifically, the auxiliary material of the step (1) and the auxiliary material of the step (2) include maltodextrin, inulin, dextrin,
One or more of soluble soybean polysaccharide, lactose.
Preferably, when the auxiliary material of the step (1) is selected from maltodextrin, concentrate in step (1): the weight of maltodextrin
The ratio between amount is 100:8~100:14, and spray powder in step (2): the weight ratio of maltodextrin is 70:30~80:20.
Further, when the sweetener is selected from Sucralose, by weight, extract spray powder: maltodextrin: trichlorine
Sucrose is 70:30:0.6.
Jujube, Poria cocos, raspberry, lily and lotus seeds are integration of drinking and medicinal herbs in the present invention, have not only increased edible safety but also have risen
To complementing estrogen, ovary, the effect of nourishing yin to moisten dryness are nourished.Jujube is sweet in flavor warm-natured, returns spleen stomach meridian, there is tonifying middle-Jiao and Qi, blood-nourishing peace
The effect of mind；Poria cocos slightly sweet flavor is flat, enters the heart, lung, the spleen channel, clearing damp and promoting diuresis, strengthening the spleen and stomach, antitoxic heart-soothing and sedative；Jujube Poria cocos is monarch
Medicine, raspberry is sweet in flavor, sour, temperature.Return liver, kidney, bladder meridian, modern research shows that raspberry is containing organic acid, carbohydrate and a small amount of dimension life
Plain C has like hormone-like effect, is ministerial drug；Lily is sweet in flavor, cold in nature, distributed in heart and lung channels.Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing；Lotus seeds are mild-natured,
Sweet-puckery flavor enters the heart, spleen, kidney channel.Tonifying spleen and stopping diarrhea, kidney-nourishing is puckery clear, mental-tranquilization, is adjutant；Five medicines share, and complement each other.
The present composition is that life Chinese medicine eats dual-purpose common food materials, is easily received, can be reduced makes user in psychology
The rejection feeling of upper generation increases edible comfort, and it can not only cook health food long-term use, but also the good medicine that can cure the disease.It should
Composition proves there is remarkable result to rat climacteric syndrome is improved through effect experiment.In addition, the present composition is made into
Solid beverage brew the clarification of rear liquid, special taste, be conducive to consumer and receive.
Specific embodiment
Inventor has carried out experimental study to technical solution provided by the invention, for proving technical effect of the invention,
Following experiments do not limit the present invention for further illustrating technical effect of the invention.
It should be noted that the person that is such as not specified actual conditions, carries out according to conventional conditions or manufacturer's recommended conditions,
Raw materials used or auxiliary material and reagents or instruments used without specified manufacturer, being can be by the routine of commercially available acquisition
Product.Unless otherwise stated, otherwise all percentage, ratio, ratio or number be by weight.
Unless otherwise defined, it anticipates known to all professional and scientific terms as used herein and one skilled in the art
Justice is identical.In addition, any method similar to or equal to what is recorded and material can all be applied and the present invention.
The determination of 1 solid beverage preparation process of embodiment
Conventional solid beverage preparation method:
Step (1) weighs jujube 6.0kg, Poria cocos 5.0kg, raspberry 3.0kg, lily 3.0kg and lotus seeds 1.0kg, removal
Impurity is cleaned；
The water of 10 times of medicinal material total amount amounts is added in step (2), and heating extraction 2 times, filtration, merging filtrate, filtrate is concentrated into phase
The concentrate for being 1.05~1.10 to density, quality 12.6kg；
Concentrate is spray-dried by step (3), obtains spray powder, and maltodextrin and Sucralose (spray are added into spray powder
Dry powder: maltodextrin: Sucralose=70:30:0.6), it mixes, granulation is packed to get solid beverage.
1, auxiliary material screens
It was placed by three months, product is easy to moisture absorption tacky, so doing preliminary screening, and combination product mouth to auxiliary material hygroscopicity
Sense is investigated.
(1) particle hydroscopicity
The glass desicator that bottom fills sodium chloride supersaturated solution is put into 5h in 40 DEG C of insulating box, at this time drier
In relative humidity be 76%.The particle of 3mm is put into the flat weighing bottle of constant weight, it is accurately weighed to be placed in drier,
Weighed weight after 20h calculates Moisture percentage by the weight before and after measurement moisture absorption.
(2) sensory evaluation
0.8g sample is taken respectively, 80 DEG C of purified water 100mL is added, and stirring and dissolving independently carries out sense organ to it by 10 people
Evaluation, makes even and is divided into its sensory evaluation scores；
1 sensory evaluation criteria of table
(3) result
2 different auxiliary material of table prepares the sensory evaluation scores and hydroscopicity of particle
| Number | Auxiliary material | Hydroscopicity (%) | Sensory evaluation scores (are divided) |
| 1 | Maltodextrin | 7.46 | 90 |
| 2 | Inulin | 12.24 | 74 |
| 3 | Dextrin | 7.82 | 69 |
| 4 | Soluble soybean polysaccharide | 8.13 | 74 |
| 5 | Lactose | 10.37 | 90 |
The experimental results showed that the particle of addition different auxiliary material preparation, maltodextrin and dextrin hydroscopicity are lower, and malt is pasted
The sensory evaluation of essence and lactose is optimal.Based on the above results, although when using maltodextrin as auxiliary material, product, which is placed three months, easily to be inhaled
It is wet tacky, but other opposite auxiliary materials, the resultant effect of maltodextrin is optimal, and it is advantageous to maltodextrins as auxiliary material.
2, the optimization of preparation process
Since maltodextrin can not improve the stability of product, product preparation process will be adjusted.
In traditional handicraft, auxiliary material directly and spray powder mixing granulation, as a result spends grain too many, medicinal material dispersion is uneven, and easy
Moisture absorption.Now change the order of addition of auxiliary material, steps are as follows:
Step (1) weighs jujube 6.0kg, Poria cocos 5.0kg, raspberry 3.0kg, lily 3.0kg and lotus seeds 1.0kg, removal
Impurity is cleaned；
The water of 10 times of medicinal material total amount amounts is added in step (2), and heating extraction 2 times, filtration, merging filtrate, filtrate is concentrated into phase
The concentrate for being 1.05~1.10 to density, quality 12.6kg；
Step (3) is added 12% maltodextrin (in terms of concentrate) into concentrate, and spray drying obtains spray powder；
Step (4) be added into spray powder maltodextrin and Sucralose (spray powder: maltodextrin: Sucralose=70:
30:0.6), it mixes, granulation is packed to get solid beverage.
It places 24 months, product characteristics are stablized, without the tacky phenomenon of moisture absorption.
The results show that a small amount of auxiliary material maltodextrin is added before spray drying, thus it is possible to vary the stability of product characteristics.
Embodiment 2 improves climacteric syndrome functional experiment
1 experimental material and method
1.1 experimental animals and drug
11-15 month female SD rat, cleaning grade, weight 280-350g；4~6 monthly ages, weight 150~220g SD female
Rat.
Experimental drug: the spray powder in 1 optimum preparation condition step (3) of embodiment.
Positive drug: soybean isoflavone extract.
1.2 experimental group
Via vagina cell smear inspection, being presented the irregular oestrous cycle is determined as climacteric mouse.It is assigned randomly to climacteric
Phase model group, positive controls, experimental group, every group 10.Optionally 4~6 monthly ages, 150~220g of weight female sd inbred rats 10
As young control.
1.3 administration
If climacteric model group, experimental group, isoflavones group (i.e. positive controls) and young control.Experimental group is given
By 840mg/kgd sample 2ml (in terms of spray powder), isoflavones group gives 500mg/kgd isoflavones 2ml, more
Term model group and young control give 0.9% physiological saline 2ml, and continuous 6 weeks.
1.4 observation items and method
Each group experimental animal is put to death after taking abdominal aorta blood sample, is extractd ovary and is carried out pathologic finding.
1.4.1 determination of serology: estrogen (E2) horizontal measurement uses immunochemiluminescence method.
1.4.2 ovarian histology slice om observation: each group rats with bilateral ovary formalin that will be extractd
Fixed, paraffin embedding, slice, piece is 6 μm thick, HE dyeing, primordial follicle, growing follicle in low power microscopic observation ovary cross section
(including primary follicle and secondary follicle), degeneration ovarian follicle and corpus luteum number.
2 results
2.1E2Measurement
As seen from Table 3, climacteric model group is compared with young control, E2Level is substantially reduced (P < 0.01).Each medication
Group E2Level increases (P < 0.05), and wherein experimental group effect is more apparent.
3 each group rat E of table2Test result
* P < 0.05, compared with climacteric control group；#P < 0.01, compared with young control.
The change of 2.2 ovarian morphologys
Climacteric model group primordial follicle is few, and degeneration ovarian follicle is more, and normotrophic ovarian follicle is few, and corpus luteum number is few；Experimental group
Normotrophic ovarian follicle is more, and growing follicle increases, and degeneration ovarian follicle is few, and corpus luteum number is more；Isoflavones group is primary, secondary
Growing follicle increases, and graaffian follicle is few, and corpus luteum number is few；Young mouse group primordial follicle is more, and primary and secondary ovarian follicle increases, corpus luteum number
Mesh is most.
The experimental results showed that, the method can significantly improve E above2Level, and increase normal ovarian follicle, growing follicle
Increase, degeneration ovarian follicle is reduced, and corpus luteum number increases.Therefore the present invention has the function of to improve climacteric syndrome.
The above description of the embodiment is only used to help understand the method for the present invention and its core ideas.It should be pointed out that pair
For those skilled in the art, without departing from the principle of the present invention, the present invention can also be carried out
Some improvements and modifications, these improvements and modifications also fall within the scope of protection of the claims of the present invention.
Claims (10)
1. a kind of with the composition for improving climacteric syndrome, which is characterized in that the composition presses the raw material of following parts by weight
It is made: jujube: 1-15 parts, Poria cocos: 1-15 parts, raspberry: 1-10 parts, lily: 1-10 parts, lotus seeds: 1-6 parts.
2. composition according to claim 1, which is characterized in that the composition is made by the raw material of following parts by weight: red
Jujube: 3-12 parts, Poria cocos: 2-12 parts, raspberry: 1.5-8 parts, lily: 1.5-8 parts, lotus seeds: 0.5-4 parts.
3. composition according to claim 2, which is characterized in that the composition is made by the raw material of following parts by weight: red
Jujube: 12 parts, Poria cocos: 10 parts, raspberry: 6 parts, lily: 6 parts, lotus seeds: 2 parts.
4. the described in any item compositions of claim 1-3 have drug, food or the guarantor for improving climacteric syndrome in preparation
Application in strong product.
5. a kind of food or health care product, which is characterized in that the food or health care product are by the described in any item combinations of claim 1-3
Acceptable auxiliary material or additive are made on object and food.
6. food according to claim 5 or health care product, which is characterized in that the food or health care product are selected from solid beverage.
7. the preparation method of a kind of food as claimed in claim 6 or health care product, which comprises the following steps:
(1) jujube, Poria cocos, raspberry, lily and lotus seeds medicinal material are taken, impurity is removed, is cleaned；8-12 times of medicinal material total amount is added every time
The water of amount heating extraction 2 times, filters, merging filtrate, and filtrate is concentrated into the concentrate that relative density is 1.05~1.10, adds auxiliary
Material, spray drying, obtains spray powder, spare.
(2) spray powder in (1) is taken, auxiliary material and sweetener is added, is mixed, granulation is packed to get solid beverage.
8. preparation method according to claim 7, which is characterized in that
The auxiliary material of the step (1) and the auxiliary material of the step (2) include that maltodextrin, inulin, dextrin, soluble soybean are more
One or more of sugar, lactose.
9. preparation method according to any one of claims 8, which is characterized in that when the auxiliary material of the step (1) is selected from maltodextrin, step
Suddenly concentrate in (1): the weight ratio of maltodextrin is 100:8~100:14, spray powder in step (2): the weight of maltodextrin
The ratio between amount is 70:30~80:20.
10. preparation method as claimed in claim 7, which is characterized in that when the auxiliary material of the step (2) is selected from maltodextrin,
When the sweetener is selected from Sucralose, by weight, extract spray powder: maltodextrin: Sucralose 70:30:0.6.
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Application publication date: 20190111 |