CN104605352A - Maca and roxburgh rose nutrition composition for promoting body blood circulation and warmly invigorating kidney yang as well as preparation method and application thereof - Google Patents
Maca and roxburgh rose nutrition composition for promoting body blood circulation and warmly invigorating kidney yang as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a maca and roxburgh rose nutrition composition for promoting body blood circulation and warmly invigorating kidney yang as well as a preparation method and application thereof. The maca and roxburgh rose nutrition composition comprises maca extract and roxburgh rose juice powder. The invention further provides the application of the maca and roxburgh rose nutrition composition in preparing medicine, compositions of healthcare tonics or functional food for promoting body blood circulation and warmly invigorating kidney yang. The invention further provides a preparation, and the preparation comprises the maca and roxburgh rose nutrition composition described in the claim 1 and auxiliaries. The maca and roxburgh rose nutrition composition provided by the invention can be used for treating male sexual dysfunction and female hand and foot cold disease caused by poor blood circulation and poor renal function, sleep disorders and the like.
Description
Technical field
The present invention relates to a kind of composition, relate in particular to a kind of promotion blood circulation of human body, the agate card of warming and invigorating kidney Yang and Rosa roxburghii medicine alimentation composition, Preparation Method And The Use.
Background technology
As the saying goes; Bread is the staff of life.That is, the existence of the mankind be unable to do without to ingest and gets nutrition.
Nutrition is that supply human body is for repairing the reasonable food of old tissue, more new organization, produce power and maintenance physiological activity.To be human body absorb from alimentary canal in nutrition, utilize the nutrition food usually to sustain life activity, and enhancing development, maintains metabolism, keeps the overall process of good health." life is nutrition ".If nonnutritive, life will stop.Even breed the fetus in parent, its all nutrition are also provided by blood by mother.When fetus leave parent come this world time, start by lactation, then to obtain various nutrition by feed.Through growth, the growth of more than ten years, grow up to adult by baby, this is entirely by forming the comprehensive absorption of nutrient various in food.Enter grow up after, though combustion growth stopped, but body still continuous renewal, this renewal, be also by eat into nutriment carry out.People inherently by this people eat into nutrient form.What children grow up in the future, depend on the nutrition of his daily absorption; Can the maiden that figure is slender continue to keep graceful build, depends on the nutrition of her daily absorption; People in middle age can or can not get fat, and can or can not occur various common disease, still depends on the nutrition of his daily absorption.Can say, determine person following all be his nutrition of absorbing now, people is moulding the health of controlling oneself with healthy by eating flatly just, if food nutrition is poor, health can be very thin and weak; Food nutrition is superfluous, and health will be too obese, or suffers from the diseases such as hypertension, dyslipidemia, diabetes.Therefore, posteriori food nutrition determines health status and the life-span of a people.
In oriental countries such as China and the Korea peninsula, be impregnated with the traditional thought of " body soil is only " " side's water and soil supports a side people ", but nowadays along with economic development and Living consumption raising and day by day spread unchecked the American-European cooking culture of infiltration, with the West Europe of global diet, we mankind, the health of especially asian population there is the change allowed of no optimist, particularly health normal body temperature step-down phenomenon is very remarkable, investigation shows according to the study, between these decades, human body mean body temperature declines nearly 1 DEG C.Such as, the normal body temperature of a certain people from region is only between 50 years, and just decline 0.7 DEG C (see Fig. 1).That is the aversion to cold disease of modern humans increases, and especially the hypothermia of kidney is very serious, and " not sick " accumulates.And it is sick and cured by diet
1).
Just there is saying of ［ it being the source of ten thousand diseases that health turns cold ］ since having from ancient times.
Modern study also shows that temperature decline then causes many physiological barriers; 1) reduce immunity, as long as the body temperature of the mankind reduces by 1 DEG C, its immunity then declines 37%, or the leukocytic function administering immunity just reduces by 30%, otherwise body temperature promotes 1 DEG C, and immunity then improves 5 ~ 6 times; 2) performance of lymphocytes also reduces; 3) reduce basic metabolism, cause easily getting fat disease, human body temperature often declines 1 DEG C, and its basal metabolic rate then declines 12%, and the energy ezpenditure being equivalent to a day reduces 200 ~ 500 kilocalories.4) reduce the performance of cell Mitochondria, facilitate the environment being beneficial to carcinogenic hypothermia, hypoxemia and hyperglycaemia, 5) heat production energy response bias in glycolysis, cause fatiguability.And hypothermic improvement, should from health itself, such as actively absorbing positive food etc. can make body temperature raise, and improves its cold shape.
In sum, modern diet custom causes, and " not sick " is very general, and " not sick " can be cured by diet.Present society fills the air various health food and nutritional supplement.And develop a kind of can temperature compensation kidney, conditioning human body physiological foundation functional material be instant major issue!
Motherland's medical science is thought, the kidney of people also has dividing of negative and positive.In other words, the existing kidney deficiency of Yin of obstacle of renal function causes, and has again the deficiency of yang to cause.The kidney deficiency of Yin is multiple is born in young man, and the kidney deficiency of yang is multiple is born in person in middle and old age person.The concrete dysfunction of kidney weakness, the impotence that the premature ejaculation nocturnal emission that the kidney deficiency of Yin can be divided to cause and the kidney deficiency of yang cause.To the male sex, especially middle-aged male, the probability of happening of kidney weakness disease is quite high, and its general symptom is presented as fatigue and sexual hypoesthesia.The traditional Chinese medical science is thought, the most applicable Cordyceps sinensis etc. of taking of the male sex of the sex dysfunction caused by the kidney deficiency of Yin, the male sex of the kidney deficiency of yang is the most applicable eats agate card.Because agate card can adjust the internal system in body, make the metabolism resume combustion again of internal system, excite sexual desires, just raising property function.
There is the agate card of " Andean ginseng " laudatory title (Lepidium meyenii Walp.) (translated name is MACA or agate coffee) for the plant on a kind of plateau growing more than mountain area, Peru Andean height above sea level four km in South America, its outer image turnip, same radish, horseradish, cauliflower equally belong to Cruciferae, its nutritional labeling concentrates on bulbous portion, therefore mainly uses its subterranean root (rhizome).Agate card is regarded as by Inca the present that Andes god rewards generously always for thousands of years, local Inca except agate card as except the food of filling the stomach, also unexpected discovery agate card can increase the strength of muscle power, enhance tolerance and resisting fatigue, property function and the fertility of the mankind and animal can be strengthened again simultaneously, namely because the magical effectiveness of MACA, Inca is just against agate card makeup energy, and army's individual arm is strong, once establishes unique print and strengthens kingdom.
Two kinds of unique active components of plants contained by agate card--macamides and Ma Ka is rare has significant effect to balanced human's hormone secretion.She has antifatigue, increases sperm quality, regains one's strength of body, improve impotence and premature ejaculation, improves sleep, anti-climacteric, and active fertility, strengthens the effects such as memory.And agate card is that men and women is suitable for, also there is good regulating action to the climacteric metancholia of women.
Due to the nutrition containing multiple balanced and reasonable in agate card and multiple there is bioactive secondary metabolite, therefore, agate jig is for plurality kinds of health care and treatment function, can be used for traditionally strengthening energy, raising fertility, improvement function, treatment climacteric metancholia, rheumatism, depression, anemia, in addition, it also has the effects such as anticancer and anti-leukocythemia.Effect of these mysteries caused the great interest of countries in the world scientist in nearly ten years.Just worldwide be in full swing about the nutrition and health care of agate card and pharmacology, drug effect and clinical and experimental study.It will make increasing contribution for the development of the healthy cause of the mankind.
Agate card (Maca) is recommended as a kind of rare nutritious supplementary pharmaceutical to the world by-FAO (Food and Agriculture Organization of the United Nation) in 1992 Rome declaration.
Agate card (Maca) is classified as rare plant by-International Plant Genetic Resources Institute in 1992.
-international mountain-climbing confederation (UIAA) in 2000 specifies agate card for mountain-climbing food.
Calendar year 2001-American Space General Administration (NASA) is first using the space grain of agate card (Maca) as astronaut.
2002-Ma Ka (Maca) become Korean and Japanese world cup sportsman and specify nutriment.
-ministry of Health of China in 2002 official approval agate card (Maca) enters China.
-ministry of Health of China in 2011 approval maca powder is national new resource food (2011 No. 13).
The major function of agate card is summarized as follows:
For the male sex
1, in antifatigue, enhancing energy, muscle power-agate card, the composition such as amino acid, mineral matter zinc, taurine can obviously to antifatigue.
2, improvement function, increases sperm quantity, and sperm motility---exclusive bioactivator agate coffee alkene, macamide, be beneficial to erection function in raising, improves sperm quantity and enlivens ability.
3, regulate internal system, hormone---the multiple alkaloid of agate card acts on hypothalamus and pituitary to balance, regulates the functions such as adrenal gland, pancreas, testis, reaches balance hormone level.
For women
1, endocrine is regulated.As everyone knows, all of women comprise body, psychology, skin controlled by estrogen, and estrogen is by ovarian secretion.The alkaloids such as agate card alkene (macaenes), macamides (macamides) can regulate the function such as adrenal gland, pancreas, ovary of women, again can hormone level in its body balanced.In addition, the taurine that agate card is rich in, protein etc. can improve the circulation of blood and lymph liquid, again can regulation of physiological functions and alleviate menopause symptom.
2, strengthen immunologic function, antifatigue, anti-anemia action---agate card is containing the iron of higher amount, and protein, amino acid, mineral matter zinc etc. can help firm immune system, promotes body premunition, to antifatigue, improves Anemia.
Meridian distribution of property and flavor: agate card taste is sweet, property is put down.Enter lung, kidney channel.
Function cures mainly: the function of the strong kidney lung of agate jig, and agate card is to the ice-cold disease of the trick caused because of renal dysfunction and aversion to cold disease, and depression, burnout, irregular menstruation, ovarian atrophy, both sexes aphoria, impotence, premature ejaculation, sexual hypoesthesia etc. have very effective therapeutic action.Especially can alleviate the menopause symptom of women, or delay senility, to the frequent micturition caused by prostate hyperplasia, urgent urination, urine waits, and urinates unablely to wait disease very effective.
Agate card can promote the benign cycle of systemic blood flow, and improves hypothermia and low blood pressure and build up the health of good circulation, is a kind of food for regaining one's strength.Although its main component is carbohydrate, with regard to root class dish, it is but rich in protein, especially containing a large amount of various essential amino acids, is also rich in semi-dispensable amino acid-arginine.
The primary bioactive components of table 1. agate card and physiological function
| Trophic function composition | Physiological function |
| Agate card alkene, macamides | Promote the secretion of male hormones, the vigor of raising spermary, promotion property function |
| Amino acid | Antifatigue, the metabolic function improving human body, supplementary kidney vigor |
| Glucosinolates | Anticancer, enhancing body immunity |
| Sterol | Angiocardiopathy preventing, increases the secretion of cortisol, raises libido |
In addition, Ma Ka is also rich in food fiber, mineral composition, vitamin, alkaloid, anthocyanin, steroid, compositions such as dextrin and remain good balance, can be called all-round food.These abundant nutritional labelings can work in complementation, and the functions such as the hormone system of enhancing health and immune system, improve various uncomfortable.
Agate card is a kind of desirable amino acid supply source, is especially rich in the mother-lysine (55mg/g) of amino acid and the father-arginine (99mg/g) of amino acid.Lysine has and improves the function of female fertility, and arginine form 80 percent of male germ cell.Arginine can promote to have the HGH secretion of " rejuvenation hormone " laudatory title, the ovum of women is grown up, and has the function of activation spermary (testis), and it can also improve quantity and the state of sperm.
Arginine is a kind of nonessential amino acid, can synthesize voluntarily in vivo.One of arginic effect promotes Ink vessel transfusing generation nitric oxide (see Fig. 2), and expand blood vessel and just prevent, improve hypertension, also defend the aging of blood vessel by soft blood vessel, and artery sclerosis and arteriosclerotic disease are played to prevention, improve effect.In addition, arginine also acts on the hormonal secretion of pituitary growth promoting effects, and increases muscle, promotes fat combustion and then prevention and effect ground improves fat and hyperlipidemia.In addition to functions described above, arginine facilitates insulin synthesis in addition, and improves its function, reduces blood sugar level, so can prevent, improve diabetes, also can strong sclerotin, and to be expected to for the prevention of osteoporosis, improvement.Arginine can also improve immunity, can be used for the prevention of infectious disease and cancer, improves etc.
In body, nitric oxide is responsible for very important function, and it, by keeping contraction and the expansion balance of blood vessel, improves blood flow.And the indispensable citrulling of nitric oxide production synthesis (see Fig. 2).If poor blood circulation, just cause the complication such as the reduction of viscera function, edema, aversion to cold disease and metabolic syndrome.By activate NO circulation normal operation, improve blood flow, be expected to improve metabolism, set up, improve aversion to cold disease and edema, improve skin sparing etc.
A. pharmacological action:
1. muscle power is strengthened
2)
Agate jig has adaptation former state (adaptogen) to act on.Swimming test according to small white mouse shows, the average swim time of control group is 886 seconds, and the average swim time average of agate card group can extend to 1463 seconds.In addition, in low temperature pond, allow small white mouse swim after a period of time, investigate its temperature recovery to oxygen demand during normal body temperature, control group oxygen consumption index is 98, and agate card processed group is then 86, has notable difference (see Fig. 3).
In addition, Ikeuchi etc.
3)confirm the raising endurance of agate card extract, the function of antifatigue.Small white mouse experiment shows, agate card extract group can extend swimming time, and the rising of lactic acid in blood when suppressing swimming exercise, impel the rising of blood free fatty acid and the minimizing of adipose tissue mass, and the minimizing of glycogen in tissue when suppressing motion, and the rising of blood hemoglobin concentration.That is, the agate card extract of picked-up, more can promote lipid metabolism when moving relative to glycometabolism, and when being employed for motion, required heat energy produces.In addition, increase blood hemoglobin concentration and just increase tissue oxygen quantity delivered, and be conducive to raising vigor.
Moreover the anti-obesic action of agate card extract is also proved.The anti-fat active ingredient of agate card extract is proved to be as benzyl mustard oil glycosides, and confirms it and suppress the rising of triglyceride in body weight, increase of interior fat and anti-obesic action, suppression blood, the fat deposition effect of liver.
2. tense situation of releiving (releasing the pressure)
2)
Carry out a kind of small white mouse experiment, shocked by electricity four times continuously in 12 hours, observe their tense situation.Each tense situation coefficient of control group is 28,37,37,32 respectively, and the tense situation coefficient of agate card group is respectively 19,21,22,19.Experiment end is after 24 hours, and the pressure index of agate card group is close to zero, and control group is then 13 (see Fig. 4).
3. enhancing sexual function
2)
Show according to up-to-date research, the sexual behaviour experiment parameter of the male rat of oral uptake agate card test portion, as across taking advantage of, mating incubation period, ejaculation latency, in incubation period after ejaculation, ejaculation is to the time of mating again, mating frequency, mating interval, mating usefulness etc. all improves significantly.
B. clinical observation
Show according to the clinical investigation carried out at TaiWan, China
2)take in the volunteer of 30 days agate cards, lassitude, irritable melancholy, the muscle power recovery of easily feeling tired patient, tired releasing is efficient is in 92.2%(1680 case), menstrual period uncomfortable person to recover normal menstrual period efficient be 88.7% (in 340 cases), lacking the enhancing of sexual desire person's sexual desire efficient is in 94.6%(1120 case), the enhancing of sex dysfunction person's property function, improvement rate are in 75.65%(660 case).Visible, the good results are evident for agate card (see Fig. 5).At present in worldwide, just large-scale clinical observation is launched to agate card.
Prostatic disorders, be the common problem of men with advancing age, it brings larger impact to health.Doctor trained in Western medicine theory is thought, the imbalance of male hormones and estrogen is the reason of prostate hyperplasia.In body, the conversion causing stosterone (testosterone) to dihydrotestosterone (dihydrotestosterone) is just brought out in the disorder of the proportional balancing method of sex hormone, and brings prostate hyperplasia.Agate card, by suppressing the biological action of dihydrotestosterone, adjusts the function of bladder, urethral smooth muscle.The physiologically active ingredients such as agate card alkene, macamides can enhance metabolism, improve blood circulation, and alleviate oedema and urethra infraction, and play good prevention effect and subsidy treatment to prostate hyperplasia.
Theory of traditional Chinese medical science is thought, prostate hyperplasia belongs to medical science " retention of urine " category." close " refer to urinate have some setbacks, " infirmity " refer to urinate unhappy.From at all, caused by the deficiency of kidney yang Yang-function insufficiency of kidneyzang.Therefore, treatment prostate hyperplasia, should to make up kidney yang for breach.Agate card can help weak Yuanyang, starts weak life fire, can support to urinate smooth and easy.That is, agate card just can play the function of warming yang for diuresis, and suppresses prostate hyperplasia.
1999, American Studies personnel found two kinds of physiologically active ingredients from agate card; Agate card alkene (macaenes) and macamides (macamides), and confirm that it has obvious effect to the hormonal balance of reconditioner body.Therefore agate card is referred to as " natural hormone engine ".In addition, agate card alkene and macamides work to hypothalamus and pendant, are of value to increase and the vigor of sperm count, relieving fatigue effectively, strengthen endurance, reinforced immunological system, improve premunition, keep strong vigor, improve anaemia, make skin rejuvenation etc., build up more healthy state.
Rosa roxburghii (Rosa roxburghii Tratt.) is rose family Rosa wild plant machaka, is grown on mountain area, the southwestern province such as Yunnan, Guizhou, especially abundant with Guizhou Plateau resource.Divided into the new resources of third generation fruit also known as 3G fruit.The record of " can directing oneself from boredom of food, disappears stagnant " is just had in motherland's medical science monumental work Compendium of Material Medica.Just there is edible Rosa roxburghii fresh fruit since ancient times or made medicinal history.
Rosa roxburghii is rich in various nutrients, especially vitamin C, P(rutin), first of all fruit in superoxide dismutase (SOD) the Xiong Guan world, (containing Catergen in every 100 grams of fresh fruit, 500mg, be nearly 3 times of the wild jujube coming second, be 30 times of fruit king Kiwi berry, be therefore called as Vc king; Containing citrin 5,900-13,000mg, also be ranked first position in the fruit content found at present, containing superoxide dismutase (SOD) up to 54,000U, according to the hat of wild fruit, SOD has significantly enhancing immunity of organisms and beauty functions) be therefore called " three chloroazotic acid fruits " by industry
4).
Rosa roxburghii mainly with its fruit be food.
Meridian distribution of property and flavor: Rosa roxburghii taste is sweet, sour, puckery, property is put down.Enter spleen, kidney, stomach warp.
Function cures mainly: deficiency of stomach-Yin, poor appetite, indigestion; Or eating accumulation, glutted full vexed, diarrhoea loose stool; Pyreticosis or hot summer weather hinder Tianjin, thirsty, vexed heating, scanty drak urine.
On August 17th, 2004, ministry of Health of China approval Rosa roxburghii are national new resource food (2004 No. 17).
Kidney is the organ that body weight for humans is wanted, and is easy to old and feeble organ.
According to Russell unit etc.
5-9)research shows, GRF(gold fructus rosae, common first names: Rosa roxburghii) the sclerosis incidence of Malpighian corpuscle can be reduced, basilar memebrane is kept normal condition (see Fig. 6 and 7).The SOD that the function of GRF has (1) to improve in body is active, and the free radical in scavenger-cell, and reduce the damage to cell.The structure of the theca cell of blood vascular system and function is made to maintain normal condition thus.In addition, GRF can prevent the collagen that caused by free radical with the bridge formation occurred between various enzyme in conjunction with sex change, is of value to the eubolism maintaining body; (2) function of eating of TB lymphocytes, monocyte and macrophage is adjusted, prevention or get rid of the accumulation of the macromolecular substances in Malpighian corpuscle and the increase of Malpighian corpuscle mesenteric tissue brought thus and the plumpness of basilar memebrane.That is, GRF keeps the normal cell transmission of information of capillary endothelium layer by the SOD activity improved in body.
Na
+, K
+-ATP enzyme is the very important film enzyme be extensively present in organism.To keeping the energetic supersession of the osmotic balance of intraor extracellular, the electrochemical gradient of cross-film and cell, there is very important effect.Therefore, if Na
+, K
+-atpase activity declines, and intracellular energy produces and ion transmission just obstacle occurs, and the function of cell is just influenced, facilitates senescence process.Na in biology
+, K
+-atpase activity strengthens with the age and declines.Show according to small white mouse experiment, GRF extract is to the Na of erythrocyte membrane
+, K
+-atpase activity has obviously protected effect (see Fig. 8).
Mitochondrial aging, be one of major reason of cell senescence
10).Mitochondrially agingly main to produce to the free radical in mitochondria environment and mitochondrial DNA respiratory chain and relevant to the damage of membrane structure.Mitochondrial DNA is once damaged, and the biosynthesis of the partially protein in respiratory chain just can not normally be carried out.The damage of respiratory chain directly hinders the generation of ATP.In addition, the damage of membrane structure causes mitochondrial collapse, and its quantity is tailed off.Maintain biological internal environment stable on, kidney is very important internal organs.The main energy sources of various matter transportation is the ATP that intracellular mitochondrial generates in vivo.Nephroid plastochondria is once aging, and ATP generates and is just subject to obstacle, causes Power supply to be affected, causes renal dysfunction conversely.Mitochondrial volume density (V
v) and face number density (N
a) be judge structure of mitochondria and the whether normal important indicator of function.If volume density and face number density reduce, just indicate that mitochondrial structure is in damaged condition, mitochondrial quantity just reduces.Show according to small white mouse experiment, the mitochondrial volume density of nephrocyte and the face number density of the aging model group of picked-up GRF extract all maintain normal value.That is, GRF can improve by the mitochondrial 26S Proteasome Structure and Function of the nephrocyte of laboratory mouse, and prevents mitochondrial aging, and then delay senility (see Fig. 9).
In addition, GRF is improved the function of people's red blood cell SOD activity.SOD is to superoxide radical, and hydroxy radical, hexichol-2-picryl hydrazine free radical, Ionization Potential of C-Centered Radicals has very strong elimination ability.Therefore, GRF is active by the SOD improving nephrocyte, improves the mitochondrial damage of nephrocyte.
SOD is the bioactivator of putative anti-ageing, antitumaous effect in the world.It also has antiviral, anti-radiant effect in addition, and is widely used in the prophylactic treatment of cardiovascular, chylopoietic disease and tumour.The citrin that GRF is rich in can promote ascorbic absorption and utilization, and vitamin C then promotes activity and the protective effect of SOD.Namely form the optimum chain of rings had complementary functions between three, more can strengthen the prevention effect of anticancer, anti-ageing and coronary heart disease, angiocardiopathy.In addition, GRF presents very high-caliber ORAC value (ORAC represents the absorbability of oxygen-cent red radical).The ORAC of GRF dried fruit juice is 1,100 μm of oleTE/ g, and comparatively blueberry exceeds 15 times
7).GRF is also rich in anthocyanin, and the anti-aging effects of anthocyanin is equivalent to 20 times of SOD, is described as the New type of S OD of 21 century.Because anthocyanin also has the well hypoglycemic effect with reducing blood viscosity, therefore, it is to prevention, the suppression of diabetes and recover very effective.
Summary of the invention
The invention provides a kind of for promoting agate card and the rosa roxburghii nutrition composition of blood circulation of human body, warming and invigorating kidney Yang, wherein this alimentation composition comprises agate card extract and Blackthorn pear fruit-juice powder.
Present invention also offers the preparation method of described agate card and rosa roxburghii nutrition composition, wherein the method comprises the following steps:
(1) prepare agate card extract: the rhizome of agate card, selected, clean, cut into slices, dry or dry, pulverize after, solvent extraction agate card rhizome powder, extract after filtration, i.e. obtained agate card extract after concentrated, disinfection and drying;
(2) prepare Blackthorn pear fruit-juice powder: fruit of Grossularia burejensis Berger through cleaning, select after squeezing, gained juice after filtration, i.e. obtained Blackthorn pear fruit-juice powder after concentrated, disinfection and drying;
(3) agate card extract and Blackthorn pear fruit-juice powder is mixed in proportion.
Present invention also offers the purposes in composition that is Ma Ka and rosa roxburghii nutrition composition promote the medicine of blood circulation of human body, warming and invigorating kidney Yang in preparation or health-care tonic product or functional food.
Present invention also offers a kind of preparation, it comprises described agate card and rosa roxburghii nutrition composition and auxiliary material.
Accompanying drawing explanation
Fig. 1 is the normal body temperature of a certain region nineteen fifty-seven and 2008;
Fig. 2 is NO(nitric oxide) cyclic process under arginine and citrulling exist;
Fig. 3 is in small white mouse experiment, the swimming time of agate card group and control group and oxygen consumption index;
Fig. 4 is in small white mouse experiment, the small white mouse of control group and Ma Ka group 12 hours internal stimulus 4 times and test the average tense situation coefficient of end after 24 hours;
Fig. 5 be agate card to dispelling fatigue, reply physiology and have some setbacks menstrual period, raise libido and improvement function efficient;
Fig. 6 is in small white mouse experiment, Normal group, the Malpighian corpuscle of Rosa roxburghii protection group and aging model group and sclerotic kidney corpusculum counting, and Malpighian corpuscle hardening ratio;
Fig. 7 is in small white mouse experiment, Normal group, the Malpighian corpuscle filtration barrier norphometry of Rosa roxburghii protection group and aging model group;
Fig. 8 is in small white mouse experiment, Normal group, the Na of Rosa roxburghii protection group and aging model group small mouse
+, K
+-atpase activity;
Fig. 9 is in small white mouse experiment, Normal group, the mitochondrial volume density (V of proximal tubular cell of Rosa roxburghii protection group and aging model group
v) and face number density (N
a);
Figure 10 is agate card of the present invention and rosa roxburghii nutrition composition 1 to by poor blood circulation, physical efficiency (strong and energetic), the mood (passion of the middle-aging male of the sexual disorders that renal function difference causes, positive, satisfaction and self-confident power), the improvement effect of sleep quality and body weight;
Figure 11 is agate card of the present invention and rosa roxburghii nutrition composition 1 to by poor blood circulation, and what renal function difference caused has the mood of the middle and aged women of trick or the ice-cold symptom of belly and sleep-disorder (be in a cheerful frame of mind (heat)), four limbs or the ice-cold disease of belly, beauty treatment skin makeup, improvement effect that is smooth and easy, body weight of falling asleep.
Detailed description of the invention
A first aspect of the present invention provides a kind of for promoting agate card and the rosa roxburghii nutrition composition of blood circulation of human body, warming and invigorating kidney Yang, and wherein this agate card and rosa roxburghii nutrition composition comprise agate card extract and Blackthorn pear fruit-juice powder.
Agate card composition and Rosa roxburghii composition all have very strong anti-oxidation characteristics, but they respectively have its own limitation.For example, agate card composition can eliminate O effectively
2-, and not obvious to the eradicating efficacy of OH.On the contrary, Rosa roxburghii composition can eliminate OH effectively.According to the thought of the traditional Chinese medical science, agate card composition can be mended " the congenital foundation (kidney) ", and Rosa roxburghii composition can be mended " the foundation of acquired constitution (spleen) ".Agate card can reinvigoration, namely first to human body extra-nutrition material, then stimulates hormone secretion, helps firm immune system, make the male sex to antifatigue, can strengthen its energy and muscle power.The present invention by the generation by agate card extract and Blackthorn pear fruit-juice powder reasonably combined promotion body intracellular nitric oxide, thus improves the circulation of body inner blood, and prevention and Cardiovarscular, improve renal function, and then reach strong health-care effect.
In a specific embodiment, it is 1-9 part that described agate card and rosa roxburghii nutrition composition comprise agate card extract by weight, and Blackthorn pear fruit-juice powder is 9-1 part.
In a specific embodiment, it is 1 part that described agate card and rosa roxburghii nutrition composition comprise agate card extract by weight, and Blackthorn pear fruit-juice powder is 1 part.
Another aspect provides the preparation method of described agate card and rosa roxburghii nutrition composition, the method comprises the following steps:
(1) prepare agate card extract: the rhizome of agate card, selected, clean, cut into slices, dry or dry, pulverize after, solvent extraction agate card rhizome powder, extract after filtration, i.e. obtained agate card extract after concentrated, disinfection and drying;
(2) prepare Blackthorn pear fruit-juice powder: fruit of Grossularia burejensis Berger through cleaning, select after squeezing, gained juice after filtration, i.e. obtained Blackthorn pear fruit-juice powder after concentrated, disinfection and drying;
(3) agate card extract and Blackthorn pear fruit-juice powder is mixed in proportion.
In a specific embodiment, in step (1), described oven dry is carried out at 60-80 DEG C.
In a specific embodiment, in step (1), the rhizome of agate card dries rear pulverizing, crosses 40 mesh sieves.
In a specific embodiment, in step (1), the process of solvent extraction agate card rhizome powder is that agate card rhizome powder solvent soaks 3-7 days at 10-80 DEG C, repeats this process 2-3 time, or extract 20 minutes-3 hours with under solvothermal counterflow condition, repeat this process 2-3 time.Preferably, ethanol or the methyl alcohol of this solvent to be volume fraction be 50-100%, or its mixture.
In a specific embodiment, in step (1), the process of solvent extraction agate card rhizome powder is that agate card rhizome powder distilled water ultrasonic wave extracts, and repeats this process 2-3 time, or at room temperature soaks rear Microwave Extraction with distilled water, repeat this process 2-3 time.
Another aspect of the invention provides the purposes in composition that is described agate card and rosa roxburghii nutrition composition promote the medicine of blood circulation of human body, warming and invigorating kidney Yang in preparation or health-care tonic product or functional food.
In a specific embodiment, described medicine or the composition of health-care tonic product or functional food for improving or treat the sex dysfunction of man, the frigidity of woman or occur climacteric advanced symptoms or appearance gloss disappearance, poor sleeping quality etc. too early.
Can be any functional food at this said functional food, include but not limited to dairy products, ice cream, biscuit, bean product, bakery, the cake of flour, cake and bread, instant product, dip, soup, instant food, frozen food, flavouring, preserved fruit, grease, margarine, cereal product, beverage and milk shake, candy and chocolate.
Can be any health-care tonic product at this said health-care tonic product composition, it can be any part as a kind of food or food, has the material of medical treatment or health advantage, comprises prevention and therapy disease or dysfunction.Such health-care tonic product composition includes but not limited to food additives, food supplement, supplements, genetically engineered food as vegetables, herbaceous plant goods, and processed food is as cereal product, the food of soup and beverage and excited function, curative effect food.
In one embodiment of the invention, medicine or health-care tonic product composition take the form of dose delivery.
The suitable method of administration of pharmaceutical composition of the present invention is oral, oral cavity, sublingual administration.In one embodiment, composition is given by oral.
Pharmaceutical composition dosage and mode must depend on the result for the treatment of that will reach accurately, also and can need the age of the individual subjects giving composition and the difference of condition and change along with the approach of specific prescription, administration.
Present invention also offers the composition of the medicine of the present invention mixed with (pharmaceutically acceptable) auxiliary material and other optional therapeutic agent, auxiliary material must be " acceptable ", mean that other composition of it and composition is compatible, and harmless to recipient.Auxiliary material, is also referred to as auxiliary element, comprises that those are usual in the industry, image carrier, filler, adhesive, diluent, drier, disintegrant, lubricant, colouring agent, flavor enhancement, antioxidant, and wetting agent.
Can being prepared by the method that any medicament industry is known with health-care tonic composition of medicine.These methods comprise the step that Ma Ka and rosa roxburghii nutrition composition are combined with any auxiliary material.
Medicine of the present invention can also comprise edible fiber further, aromatic, taste component with health-care tonic composition, and control the composition of physical property and organoleptic properties.
The dosage device that the pharmaceutical composition being suitable for oral administration can disperse provides, such as pill, tablet, pellet, sugar-coat ingot, or capsule, or powder or granule, or solution, suspension or elixir.
Composition of the present invention (no matter be medicine, health-care tonic) or product (such as functional food) can combine (i.e. composite treatment) with other methods for the treatment of known in the art.That is, when utilizing composition of the present invention or product to promote blood circulation of human body, warming and invigorating kidney Yang, the common drug of blood circulation of human body, warming and invigorating kidney Yang can be promoted in conjunction with other.
Medicine of the present invention or the composition of health-care tonic product or functional food also together with other compound, folic acid can be included but not limited to, vitamins, mineral matter class, amino acids, ucleotides, antioxidant etc. are administration together.
Another aspect of the invention provides a kind of preparation, and it comprises described agate card and rosa roxburghii nutrition composition and auxiliary material.
In a specific embodiment, described preparation is capsule form.
In a specific embodiment, described preparation is drink form.
In a specific embodiment, described preparation is tablet.
In one more specifically embodiment, described tablet comprises the composition of following weight parts:
Agate card extract 0.1-40,
Blackthorn pear fruit-juice powder 0.1-40,
Cit 0.1-20,
Dextrin 0.1-20,
Ginseng Root Powder 0.1-20,
Zn-contained yeast 0.1-20,
Selenium yeast 0.1-20,
Avicel cellulose 0.1-20,
Yeast cell wall 0.1-20,
L-arginine 0.1-20,
Carbon powder pigment 0.1-20,
Dolomol (calcium) 0.1-20,
Silica 0.1-20,
Glycerine 0.1-20,
Cacao color 0.1-20,
Gloss additive 0.1-20.
Preferably, described tablet comprises the composition of following weight parts:
Agate card extract 2-10,
Fructus Rosae Normalis extract 2-10,
Cit, dextrin, Ginseng Root Powder, Zn-contained yeast, selenium yeast, avicel cellulose, yeast cell wall, L-arginine, carbon powder pigment, dolomol (calcium), silica, glycerine, cacao color and gloss additive summation are 1-5.
The composition of agate card extract provided by the present invention and Blackthorn pear fruit-juice powder has replenishing essence kidney tonifying, strong muscles and bones, moisturizing moistening face, can be used for improvement or treats man's hyposexuality, impotence or act and not hard, premature ejaculation; Woman's frigidity or occur climacteric advanced symptoms too early; Or with appearance gloss disappearance, poor sleeping quality.And said composition is also by the adjustment to neuroendocrine system, strengthens human body gonad axis primary biochemical active, and then improve human reproductive system's function, improve the hormone secretion of masculinity and femininity; Delay is old and feeble; Promote Skin Cell active, delay to lose one's looks; And improving water flood effect.
The present invention follows the combination principle of " monarch, minister, help, make " of the traditional Chinese medical science, by agate card extract and GRF extract by golden rule collocation, makes it to complement each other, promotes blood circulation good in body.
Below by specific embodiment, the present invention is further described, but the present invention does not limit to and the following example.
Embodiment 1
Agate card extraction process is as follows: agate card rhizome
→select
→cleaning
→section
→dry
→pulverize
→leaching
→filter
→concentrated
→disinfection
→spraying dry
→finished product
Agate card extract is prepared according to one of following method according to above-mentioned technique:
Method one:
Select agate card (Peru originates in agate card or the domestic cultivation agate card) rhizome not having to rot, with section after water cleaning, the rhizome after section dries or dries, and pulverizes with pulverizer.Get agate card rhizome powder, join under normal temperature in the ethanol of 75% of its 4 times of weight (25 DEG C) and soak 3 days, filter, filter residue to use the same method extraction twice (namely extracting 3 times altogether) with the ethanol of 75% of above-mentioned weight again.Finally filtrate is merged, i.e. obtained agate card extract after concentrated, disinfection and drying.
Method two:
Select agate card (Peru originates in agate card or the domestic cultivation agate card) rhizome not having to rot, with section after water cleaning, the rhizome after section dries or dries, and pulverizes with pulverizer.Get agate card rhizome powder, join in the methyl alcohol of its 4 times of weight and add hot reflux 1 hour, filter, filter residue to use the same method extraction twice (namely altogether extract 3 times) with the methyl alcohol of above-mentioned weight again.Finally filtrate is merged, i.e. obtained agate card extract after concentrated, disinfection and drying.
Method three:
Select agate card (Peru originates in agate card or the domestic cultivation agate card) rhizome not having to rot, with section after water cleaning, the rhizome after section dries or dries, and pulverizes with pulverizer.Get agate card rhizome powder, to join in the distilled water of its 5 times of weight ultrasonic extraction 40 minutes, centrifugal filtration, filter residue to use the same method extraction twice (namely extracting 3 times altogether) with the distilled water of above-mentioned weight again, finally filtrate is merged, i.e. obtained agate card extract after concentrated, disinfection and drying.
Method four:
Select agate card (Peru originates in agate card or the domestic cultivation agate card) rhizome not having to rot, with section after water cleaning, the rhizome after section is pulverized with pulverizer after drying or drying.Get agate card rhizome powder, by the distilled water soak at room temperature of its 6 times of weight Microwave Extraction 1 hour after 1 day, centrifugal filtration, filtrate finally merges with the extraction twice (namely altogether extract 3 times) that uses the same method of the distilled water of above-mentioned weight by filter residue again, i.e. obtained agate card extract after concentrated, disinfection and drying.
The productive rate of agate card extract prepared by above-mentioned four kinds of methods is all substantially identical with composition.
Embodiment 2
The processing technology of Blackthorn pear fruit-juice powder is as follows:
Raw material fruit
→cleaning
→select
→squeezing
→filter
→concentrated
→disinfection
→dry
→finished product
Blackthorn pear fruit-juice powder is prepared according to the methods below according to above-mentioned processing technology:
Fruit of Grossularia burejensis Berger use water cleans, and selects and not have the fruit rotted to squeeze, and gained juice after filtration, namely obtain Blackthorn pear fruit-juice powder after concentrated, disinfection and drying.
Embodiment 3
Prepare agate card and rosa roxburghii nutrition composition.
1 part, the Blackthorn pear fruit-juice powder of the agate card extract 1 part and embodiment 2 preparation that take embodiment 1 preparation is mixed to get Ma Ka and rosa roxburghii nutrition composition 1.
9 parts, the Blackthorn pear fruit-juice powder of the agate card extract 1 part and embodiment 2 preparation that take embodiment 1 preparation is mixed to get Ma Ka and rosa roxburghii nutrition composition 2.
1 part, the Blackthorn pear fruit-juice powder of the agate card extract 9 parts and embodiment 2 preparation that take embodiment 1 preparation is mixed to get Ma Ka and rosa roxburghii nutrition composition 3.
1 part, the Blackthorn pear fruit-juice powder of the agate card extract 20 parts and embodiment 2 preparation that take embodiment 1 preparation is mixed to get Ma Ka and rosa roxburghii nutrition composition 4.
15 parts, the Blackthorn pear fruit-juice powder of the agate card extract 1 part and embodiment 2 preparation that take embodiment 1 preparation is mixed to get Ma Ka and rosa roxburghii nutrition composition 5.
Embodiment 4
The curative effect of agate card and rosa roxburghii nutrition composition 1:
The curative effect of agate card and rosa roxburghii nutrition composition 1 one ~ 3 months double blind random, placebo experiment in, to by poor blood circulation, the middle-aging male of the sexual disorders that renal function difference causes and have the middle and aged women of trick or the ice-cold symptom of belly and sleep-disorder to be studied.
According to this research and design, 160 40-70 year China/Korea S/Japanese male subjects are by random screening in following two treatment groups, and each treatment group has 80 experimenters.
(a) capsule containing 200mg agate card and rosa roxburghii nutrition composition 1, every day 3 times with administration of often eating, each 1.
B () placebo contains 230 grams of cellulosic capsules, every day 3 times with administration of often eating, each 1.
Result:
80 male subject are absorbed three months actual effects and are: 63 people (i.e. the people of 78.8%) feel oneself to become strong, energetic, during with companion person's sexual intercourse stream, make the other side perfectly contented; 56 people (i.e. the people of 70.0%) feel more have passion before oneself comparatively, become positive, just like the green years; 61 people (i.e. the people of 76.4%) satisfactorily fulfil the sexual intercourse stream with companion person, and degree of pleasing oneself and self-confident power improve; 65 people (i.e. the people of 81.3%) obtain sleep improvement (namely sleep quality is improved), and second day energetic; The body weight (BMI) of 70 people (i.e. the people of 87.5%) subtracts 9-14%, on average declines 10.0%.(above-mentioned effect is specifically see Figure 10)
According to this research and design, 160 40-70 year China/Korea S/Japanese women experimenters are by random screening in following two treatment groups, and each treatment group has 80 experimenters.
(a) capsule containing 200mg agate card and rosa roxburghii nutrition composition 1, every day 3 times with administration of often eating, each 1.
B () placebo contains 220 grams of cellulosic capsules, every day 3 times with administration of often eating, each 1.
Result:
80 female subjects absorb three months actual effects and are: more can sensibility climax when 49 people (i.e. the people of 61.3%) and partner's property are joyous, and be in a cheerful frame of mind (heat); The four limbs of 61 people (i.e. the people of 76.1%) or the belly symptom that cools improves, thus causes sleep improvement; The skin of 66 people (i.e. the people of 82.5%) becomes tender, feels that alimentation composition of the present invention has beauty treatment skin makeup, the effect shone of improving looks; 66 people (i.e. the people of 82.5%) fall asleep and become smooth and easy, and obtain satisfied sleep, feel to obtain sufficient rest; The body weight (BMI) of 72 people (i.e. the people of 90%) subtracts 8-15%, and the above-mentioned effect of average decline 8.8%(is specifically see Figure 11).
Embodiment 5
The curative effect of agate card and rosa roxburghii nutrition composition 2:
The curative effect of agate card and rosa roxburghii nutrition composition 2 one ~ 3 months double blind random, placebo experiment in, to by poor blood circulation, the middle-aging male of sexual disorders that renal function difference causes and have trick or the ice-cold symptom of belly, the middle and aged women of sleep-disorder is studied.
According to this research and design, 160 40-70 year China/Korea S/Japanese male subjects are by random screening in following two treatment groups, and each treatment group has 80 experimenters.
(a) capsule containing 200mg agate card and rosa roxburghii nutrition composition 2, every day 3 times with administration of often eating, each 1.
B () placebo contains 220 grams of cellulosic capsules, every day 3 times with administration of often eating, each 1.
Result:
80 experimenters absorb three months actual effects and are: 50 people (i.e. the people of 62.5%) feel oneself to become strong, energetic, during with companion person's sexual intercourse stream, make the other side perfectly contented; 45 people (i.e. the people of 56.3%) feel more have passion before oneself comparatively, become positive, just like the green years; 46 people (i.e. the people of 57.5%) satisfactorily fulfil the sexual intercourse stream with companion person, and degree of pleasing oneself and self-confident power improve; 53 people (i.e. the people of 66.3%) obtain sleep improvement (namely sleep quality is improved), and second day energetic; The body weight (BMI) of 62 people (i.e. the people of 77.5%) subtracts 6-11%, on average declines 8%.
According to this research and design, 160 40-70 year China/Korea S/Japanese women experimenters are by random screening in following two treatment groups, and each treatment group has 80 experimenters.
(a) capsule containing 200mg agate card and rosa roxburghii nutrition composition 2, every day 3 times with administration of often eating, each 1.
B () placebo contains 220 grams of cellulosic capsules, every day 3 times with administration of often eating, each 1.
Result: 80 experimenters absorb three months actual effects and are: more can sensibility climax when 41 people (i.e. the people of 51.3%) and partner's property are joyous, be in a cheerful frame of mind (heat); The four limbs of 40 people (i.e. the people of 50.0%) or the belly symptom that cools improves, thus causes sleep improvement; The skin of 46 people (i.e. the people of 57.5%) becomes tender, feels that alimentation composition of the present invention has beauty treatment skin makeup, the effect shone of improving looks; 42 people (i.e. the people of 52.5%) fall asleep and become smooth and easy, and obtain satisfied sleep, feel to obtain sufficient rest; The body weight (BMI) of 63 people (i.e. the people of 78.8%) subtracts 5-12%, on average declines 6%.
Embodiment 6
Agate card and rosa roxburghii nutrition composition 3,4,5 and Ma Ka extract are the curative effect of separate constituent:
The curative effect of agate card and rosa roxburghii nutrition composition 3:
Agate card and rosa roxburghii nutrition composition 3 at 10 by poor blood circulation, the middle-aging male of sexual disorders that renal function difference causes and 10 are by poor blood circulation, and the middle and aged women of trick or the ice-cold symptom of belly and sleep-disorder that has that renal function difference causes is studied with it.
Experimenter contains the capsule of 200mg agate card and rosa roxburghii nutrition composition 3 every day for three times with acceptance 1 of often eating.
Result:
The test result of male subject is better than the result taking Ma Ka and rosa roxburghii nutrition composition 2 a little, but obviously good not as the result taking Ma Ka and rosa roxburghii nutrition composition 1.
The test result of female subjects is suitable with the result taking Ma Ka and rosa roxburghii nutrition composition 2, but obviously good not as the result taking Ma Ka and rosa roxburghii nutrition composition 1.
The curative effect of agate card and rosa roxburghii nutrition composition 4:
Agate card and rosa roxburghii nutrition composition 4 at 10 by poor blood circulation, the middle-aging male of sexual disorders that renal function difference causes and 10 are by poor blood circulation, and the middle and aged women of trick or the ice-cold symptom of belly and sleep-disorder that has that renal function difference causes is studied with it.
Experimenter contains the capsule of 200mg agate card and rosa roxburghii nutrition composition 4 every day for three times with acceptance 1 of often eating.
Result:
The test result of male subject is inferior to the result taking Ma Ka and rosa roxburghii nutrition composition 2, and also the obvious result not as taking Ma Ka and rosa roxburghii nutrition composition 1 is good.
The test result of female subjects is inferior to the result taking Ma Ka and rosa roxburghii nutrition composition 2, and also the obvious result not as taking Ma Ka and rosa roxburghii nutrition composition 1 is good.
The curative effect of agate card and rosa roxburghii nutrition composition 5:
Agate card and rosa roxburghii nutrition composition 5 at 10 by poor blood circulation, the middle-aging male of sexual disorders that renal function difference causes and 10 are by poor blood circulation, and the middle and aged women of trick or the ice-cold symptom of belly and sleep-disorder that has that renal function difference causes is studied with it.
Experimenter contains the capsule of 200mg agate card and rosa roxburghii nutrition composition 5 every day for three times with acceptance 1 of often eating.
Result:
The test result of male subject is inferior to the result taking Ma Ka and rosa roxburghii nutrition composition 2, and also the obvious result not as taking Ma Ka and rosa roxburghii nutrition composition 1 is good.
The test result of female subjects is inferior to the result taking Ma Ka and rosa roxburghii nutrition composition 2, and also the obvious result not as taking Ma Ka and rosa roxburghii nutrition composition 1 is good.
The curative effect of independent agate card extract:
Be used alone agate card extract at 10 by poor blood circulation, the middle-aging male of sexual disorders that renal function difference causes and 10 are by poor blood circulation, and the middle and aged women of trick or the ice-cold symptom of belly and sleep-disorder that has that renal function difference causes is studied with it.
Experimenter contains the capsule of 200mg agate card extract every day for three times with acceptance 1 of often eating.
Result:
The test result of male subject is inferior to the result taking Ma Ka and rosa roxburghii nutrition composition 2, and also the obvious result not as taking Ma Ka and rosa roxburghii nutrition composition 1 is good.
The test result of female subjects is inferior to the result taking Ma Ka and rosa roxburghii nutrition composition 2, and also the obvious result not as taking Ma Ka and rosa roxburghii nutrition composition 1 is good.
Embodiment 7
Comprise 1000, the tablet of agate card of the present invention and rosa roxburghii nutrition composition for preparation, stock and adjunct proportioning used is as follows:
Agate card extract 30g,
Fructus Rosae Normalis extract 30g,
Cit 10g,
Dextrin 5g,
Ginseng Root Powder 6g,
Zn-contained yeast 0.5g,
Selenium yeast 0.3g,
Avicel cellulose 1g,
Yeast cell wall 2g,
L-arginine 12g,
Carbon powder pigment 0.2g,
Dolomol (calcium) 3g,
Silica 4g,
Glycerine 0.9g,
Cacao color 1g,
Gloss additive 5g,
Adopt the preparation technology of conventional tablet to make, every sheet heavily about 0.1g, every sheet is containing agate card extract and Blackthorn pear fruit-juice powder 0.06g.Usage: be grown up three times on the one, each 3 oral.
Embodiment 8
Comprise 200, the tablet of agate card of the present invention and rosa roxburghii nutrition composition for preparation, stock and adjunct proportioning used is as follows:
Agate card extract 6g,
Fructus Rosae Normalis extract 8g,
Cit 0.8g,
Dextrin 0.2g,
Ginseng Root Powder 0.3g,
Zn-contained yeast 0.1g,
Selenium yeast 0.1g,
Avicel cellulose 0.2g,
Yeast cell wall 0.1g,
L-arginine 0.8g,
Carbon powder pigment 0.2g,
Dolomol (calcium) 0.1g,
Silica 0.1g,
Glycerine 0.1g,
Cacao color 0.2g,
Gloss additive 0.2g,
Adopt the preparation technology of conventional tablet to make, every sheet heavily about 0.1g, every sheet is containing agate card extract and Blackthorn pear fruit-juice powder 0.07g.Usage: be grown up three times on the one, each 3 oral.
Embodiment 9
As follows for the stock and adjunct proportioning preparing this powder 100 bags containing agate card of the present invention and rosa roxburghii nutrition composition used:
Agate card extract 12g
Blackthorn pear fruit-juice powder 8g
Lactose 260 g
Starch slurry (10%) 20 g
Adopt the preparation technology of conventional powder to make, every bag heavy 3 g, every bag containing agate card extract and Blackthorn pear fruit-juice powder 0.2g.Usage: be grown up three times on the one, each 1 sack clothes.
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Claims (14)
1., for promoting agate card and the rosa roxburghii nutrition composition of blood circulation of human body, warming and invigorating kidney Yang, wherein this alimentation composition comprises agate card extract and Blackthorn pear fruit-juice powder.
2. agate card according to claim 1 and rosa roxburghii nutrition composition, wherein agate card extract is 1-9 part by weight, and Blackthorn pear fruit-juice powder is 9-1 part.
3. agate card according to claim 1 and rosa roxburghii nutrition composition, wherein agate card extract is 1 part by weight, and Blackthorn pear fruit-juice powder is 1 part.
4. the agate card described in any one of claim 1-3 and a preparation method for rosa roxburghii nutrition composition, it is characterized in that, the method comprises the following steps:
(1) prepare agate card extract: the rhizome of agate card is selected, clean, cut into slices, dry or dry, pulverize after, solvent extraction agate card rhizome powder, extract after filtration, i.e. obtained agate card extract after concentrated, disinfection and drying;
(2) prepare Blackthorn pear fruit-juice powder: fruit of Grossularia burejensis Berger through cleaning, select after squeezing, gained juice after filtration, i.e. obtained Blackthorn pear fruit-juice powder after concentrated, disinfection and drying;
(3) agate card extract and Blackthorn pear fruit-juice powder is mixed in proportion.
5. preparation method according to claim 4, is characterized in that, in step (1), described oven dry is carried out at 60-80 DEG C.
6. preparation method according to claim 4, it is characterized in that, in step (1), the process of solvent extraction agate card rhizome powder is that agate card rhizome powder solvent soaks 3-7 days at 10-80 DEG C, repeat this process 2-3 time, or extract 20 minutes-3 hours with under solvothermal counterflow condition, repeat this process 2-3 time.
7. preparation method according to claim 6, is characterized in that, ethanol or the methyl alcohol of described solvent to be volume fraction be 5-100%, or its mixture.
8. preparation method according to claim 4, it is characterized in that, in step (1), the process of solvent extraction agate card rhizome powder is that agate card rhizome powder distilled water ultrasonic wave extracts, repeat this process 2-3 time, or at room temperature soak rear Microwave Extraction with distilled water, repeat this process 2-3 time.
9. the purposes in composition that the is agate card described in any one of claim 1-3 and rosa roxburghii nutrition composition promote the medicine of blood circulation of human body, warming and invigorating kidney Yang in preparation or health-care tonic product or functional food.
10. purposes according to claim 9, wherein said medicine or the composition of health-care tonic product or functional food be used for the treatment of the sex dysfunction of man, the frigidity of woman or occur climacteric advanced symptoms or appearance gloss disappearance, poor sleeping quality too early.
11. 1 kinds of preparations, it comprises agate card described in any one of claim 1-3 and rosa roxburghii nutrition composition and auxiliary material.
12. preparations according to claim 11, it is tablet, capsule, powder or oral liquid.
13. preparations according to claim 12, described tablet comprises the composition of following weight parts:
Agate card extract 0.1-40,
Blackthorn pear fruit-juice powder 0.1-40,
Cit 0.1-20,
Dextrin 0.1-20,
Ginseng Root Powder 0.1-20,
Zn-contained yeast 0.1-20,
Selenium yeast 0.1-20,
Avicel cellulose 0.1-20,
Yeast cell wall 0.1-20,
L-arginine 0.1-20,
Carbon powder pigment 0.1-20,
Dolomol (calcium) 0.1-20,
Silica 0.1-20,
Glycerine 0.1-20,
Cacao color 0.1-20,
Gloss additive 0.1-20.
14. preparations according to claim 13, described tablet comprises the composition of following weight parts:
Agate card extract 2-10,
Fructus Rosae Normalis extract 2-10,
The summation of all the other compositions is 1-5.
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Cited By (5)
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| CN106036878A (en) * | 2016-06-29 | 2016-10-26 | 中科和素（天津）医药科技有限公司 | Special nutritional preparation for repair of male germ cell, and preparation method of nutritional preparation |
| CN106036878B (en) * | 2016-06-29 | 2020-02-21 | 中科和素（天津）医药科技有限公司 | Special nutritional preparation for male germ cell repair and preparation method thereof |
| CN106539907A (en) * | 2016-10-31 | 2017-03-29 | 广西金臣科技有限公司 | Agate card enzyme nutrient solution and preparation method thereof |
| CN112618614A (en) * | 2021-01-08 | 2021-04-09 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | Rosa roxburghii active extract with anti-depression effect and application thereof |
| CN112618614B (en) * | 2021-01-08 | 2022-10-28 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | Rosa roxburghii active extract with anti-depression effect and application thereof |
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