CN104083468A - Medicine for treating male oligospermia and asthenozoospermia and improving sperm quality - Google Patents
Medicine for treating male oligospermia and asthenozoospermia and improving sperm quality Download PDFInfo
- Publication number
- CN104083468A CN104083468A CN201410240400.XA CN201410240400A CN104083468A CN 104083468 A CN104083468 A CN 104083468A CN 201410240400 A CN201410240400 A CN 201410240400A CN 104083468 A CN104083468 A CN 104083468A
- Authority
- CN
- China
- Prior art keywords
- medicine
- egg
- zinc
- enriched
- selenium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a medicine for treating male oligospermia and asthenozoospermia and improving sperm quality. The medicine for treating male oligospermia and asthenozoospermia and improving sperm quality takes L-carnitine, maca, corduceps militaris, zinc-rich selenium-rich whole egg powder, vitamin C, citric acid, zizyphus jujube, deer blood, folic acid, taurine, fructose and coenzyme Q10 as active compositions, and is prepared according to a certain weight ratio. The medicine aims at the disadvantages of conventional spermatogenic medicines, and is reasonable in formula. By properly combining multiple bulk drugs and utilizing the mutual synergic effect of the bulk drugs, the treatment effect is improved, the medicine adapts to treatment requirements of complex disease conditions, adverse reaction is reduced, and the medicine is durable in treatment effect, fast in absorption, rapid in effectiveness, strong in effect, free of stimulation, safe, reliable and simple for administration, is capable of effectively promoting generation of sperms, improving the survival rate of sperms, and is an effective medicine for treating oligospermia, asthenozoospermia and sperm quality badness caused by various reasons. The total effective rate of the medicine reaches 95.6% based on 5730 examples treated by using the medicine.
Description
(1) technical field
The present invention relates to a kind of medicine for the treatment of male oligoasthenospermia, improving sperm quality.
(2) background technology
Along with environmental pollution increases the weight of day by day, job and life stress constantly increases, bad living habit in addition, and the sickness rate of China's infertility is the trend of continuous rising in recent years, bring heavy spirit and financial burden to patient and family members, become one of key factor affecting family harmony.The sterile domestic problem of being not only, also becomes a global public social problem gradually, becomes one of important content of many national reproductive health services.In sterile case, male sterility accounts for 30%～40%, the reason of male sterility is a lot, such as testicualr development is abnormal, varicocele, sexual dysfunction and concurrent sterile etc. of various internal disease, but the patient up to 60%-75% can not find reason, they generally show as sperm quality abnormal symptoms such as oligoasthenospermia, sperm motility rate are low, sperm deformity, Sperm progressive motility ability.At present, to the treatment of male infertility, in all polytherapies of doctor trained in Western medicine, often can only treat for single pathological tissues, and cannot reach comprehensive treatment, the comprehensive effect of conditioning; And poor for oligoasthenospermia, sperm quality, be mainly to adopt various hormone therapies, though there is certain curative effect, all there is side effect in various degree; The traditional Chinese medical science is substantially all deficiency of kidney-essence to the understanding of primary disease, and treatment has the relatively large class of temperature compensation kidney tonifying and nourishing YIN for benefiting the kidney two; Chinese patent medicine also has a lot, but very different, clinically confirms that without relevant report certain Chinese medicine has obvious curative effects to dysspermatism so far, and Chinese patent medicine needs long-term taking, takes effect very slow.
(3) summary of the invention
The present invention is in order to make up the deficiencies in the prior art, provide a kind of scientific formulation, evident in efficacy, safe and reliable, can effectively promote spermatogenesis, improve sperm survival rate, strengthen motility of sperm treatment male oligoasthenospermia, improve the medicine of sperm quality.
The present invention is achieved through the following technical solutions:
A medicine for the treatment of male oligoasthenospermia, raising sperm quality, its active component is made up of the raw material of following parts by weight: L-carnitine 1-50 part, Lepidinm meyenii Walp 1-50 part, Cordyceps militaris (L.) Link. 1-50 part, Zinc-enriched selenium-enriched dried whole-egg 1-50 part, vitamin C 0.001-35 part, citric acid 0.1-0.5 part, Fructus Jujubae 1-50 part, Sanguis cervi 1-30 part, folic acid 0.001-1 part, taurine 0.004-0.2 part, fructose 0.5-1.5 part, coenzyme Q10 are 0.004-2 part.
The preparation method of described Zinc-enriched selenium-enriched dried whole-egg, comprises the steps:
(1) in common egg feedstuff per ton, add the zinc source additive of 500-3000g, the selenium source additive of 5-30g, after stirring, feed laying hen with it, feed and collect the egg that laying hen produces after 7 days, be i.e. Zinc-enriched selenium-enriched egg;
(2) Zinc-enriched selenium-enriched Ovum Gallus domesticus album is washed, washed away surperficial dust and impurity;
(3) after egg is shelled, egg liquid is stirred, filters to remove impurity, and then sieve with 20 order dusting covers;
(4) at temperature 64-65 DEG C, the egg liquid after filtering is carried out to pasteurize, the time is 5-8min;
(5) use high-pressure pump under the pressure of 15-25MPa the egg liquid through pasteurize, be the droplet of atomization shape through nozzle ejection, droplet, with entering drying tower through the hot blast of air air filter and heater heating, carries out heat exchange in drying tower, and egg liquid is dried to powdered egg powder.
(6) dry again after powdered egg moisture regain that will be dry, dry in the air that cool rear ground floor is 40 mesh sieves respectively through three layers of sieve, the second layer is 60 mesh sieves, the 3rd layer is 60 mesh sieves, obtains Zinc-enriched selenium-enriched dried whole-egg after sieving.
Described zinc source additive is zinc sulfate, zinc oxide or zinc gluconate.
Described selenium source additive is selenocarrageenan, sodium selenite or selenomethionine.
Content >=the 45mg/kg of zinc, the content >=1.5mg/kg of selenium in described Zinc-enriched selenium-enriched dried whole-egg.
The dosage form of the medicine of described treatment male oligoasthenospermia, raising sperm quality is tablet, electuary or capsule.
Usage and dosage:
The medicinal tablet 1g/ sheet for the treatment of male oligoasthenospermia, raising sperm quality, oral, every day 3 times, each 4;
The medicine instant 15g/ bag for the treatment of male oligoasthenospermia, raising sperm quality, with mixing in water for oral taking, every day 2 times, each 1 bag;
The medicine capsule 0.5g/ grain for the treatment of male oligoasthenospermia, raising sperm quality, oral, every day 3 times, each 4.
The pharmaceutical characteristic of each active component of the present invention is as follows:
L-carnitine: the energy metabolism of sperm can be strengthened and protect to L-carnitine, improve motility of sperm, in spermioteleosis process, play an important role: first, L-carnitine is the main carriers of sperm energy metabolism, it not only can be transported fatty acid and phospholipid and enter in mitochondria of sperms, also fatty acid can be transported to epididymal, then be transported to epididymis tube chamber and sperm through epididymal; Secondly, L-carnitine has the effect of antagonism Damage Induced by Reactive Oxygen Species, reactive oxygen species (ROS) is the important sources that causes sperm DNA (deoxyribonucleic acid) (DNA) mitochondrial injury, can cause silicosis oxidant and anti-oxidant system dysequilibrium in testis, thereby affect sperm function; In addition, L-carnitine also has the effect of antibiosis spermatid and Sperm Apoptosis;
Lepidinm meyenii Walp: for male, the compositions such as the aminoacid that contains in Lepidinm meyenii Walp, mineral zinc, taurine are fatigue alleviating obviously, physical strength reinforcing; The active substance Lepidinm meyenii Walp alkene containing in Lepidinm meyenii Walp and Lepidinm meyenii Walp amide have the sexual function of promotion, improve sperm quantity and enliven the effect of ability; The multiple alkaloid containing in Lepidinm meyenii Walp acts on hypothalamus and hypophysis cerebri, can regulate the functions such as adrenal gland, pancreas, testis, realizes the effect of balance hormone level, and making sperm produce number increases; The arginine containing in Lepidinm meyenii Walp is amino acid whose main component in sperm, the mobility that can improve sperm; Imitative fructose in Lepidinm meyenii Walp can provide energy for sperm;
Cordyceps militaris (L.) Link.: sweet in the mouth, property are put down, and enter lung, kidney two warps; There is lung benefiting kidney, mend marrow, the merit of enriching blood and reducing phlegm; Modern medicine study shows, Cordyceps militaris (L.) Link., containing abundant adenosine, can effectively strengthen motility of sperm, extends its life span;
Zinc-enriched selenium-enriched dried whole-egg: zinc, selenium are the necessary important trace element of human body, closely related with reproductive system metabolic function, the division to sexual cell, breeding, the required variation of a series of enzymes and the environment of an activation of sperm of sperm forming process all play an important role; Research thinks, trace element zinc and selenium are very large on the impact of sperm quality, and when zinc in male genetic road, Se content are higher, spermatogenesis ability is also comparatively active, and the low selenium of low zinc is one of major reason of male sterility; Zinc and sperm concentration, motility of sperm and sperm quantity are all closely related, and important effect is played in the generation of sexual development to body, sexual function, sexual cell; In the middle of the testis of human body, prostate, seminal fluid, all contain the zinc of high concentration, in the time that the content of zinc in human body lacks, sexual function can be therefore and low, and synthetic Testosterone enzyme gets muddled, and man will cause sexual impotence; Zinc is to exciting sperm motility to have special effect, and zinc deficiency can cause the decline of motility of sperm; Selenium is in the generation of sperm with maintain the aspects such as the stability of sperm and have very large effect, selenium is one of composition of mitochondria of sperms outer membrane protein, can prevent and treat the lipid oxidation on film, thereby after birth and mitochondrion are had to protective effect, if cell biological film is received damage, will affect copying of DNA, finally affect the generation of sperm; Tradition zinc supplement, selenium supplement product, owing to being unfavorable for absorption of human body utilization, cause taking dose large, DeGrain, and inorganic zinc (as zinc sulfate) stimulating intestine and stomach, causes nausea, vomiting; Organic zinc (as zinc gluconate, zinc lactate) has certain side effect, the absorption of other elements such as antagonism calcium ferrum, and long-term taking, causes the symptom such as calcium deficiency, anemia.Make a living states of matter type protein-zinc and albumen selenium of contained zinc, selenium in the Zinc-enriched selenium-enriched dried whole-egg of the present invention, its version is consistent with zinc, the selenium form in human body, therefore good absorbing, active high, and protein and zinc, selenium are in conjunction with relative firm, can not separate out under one's belt zinc, plasma selenium, can toxic side effect, can long-term safety take, overcome that inorganic supplementary absorbance was low in the past, the defect slow, side effect is large takes effect, the utilization that can be absorbed by the body fast and effectively, has safeguarded the physiological function of prostate and reproductive system; The biological state type protein-zinc of the present invention and albumen selenium can participate in and protect the synthesizing of prostaglandin, the formation of sperm, a series of physiological and biochemical procedures of sperm breathing energy supply, also there is immunomodulating simultaneously, improve enzyme activity, increase antimicrobial factors in prostate, remove the effects such as free radical, the various symptoms that cause for the infertility causing because of oligoasthenospermia, Semen non-liquefaction etc. and prostatitis (hypertrophy) are all significantly improved;
Vitamin C: be a kind of antioxidant being present in seminal fluid, can alleviate the oxidation stress of ascorbate peroxidase enzyme substrate, protection oxygen free radical injury sperm, vitimin supplement C can improve sperm quality;
Citric acid: can regulate the concentration of calcium ion in seminal fluid, the liquefaction of semen is had a certain impact, can strengthen and protect the energy metabolism of sperm, improve the vigor of mankind spermatozoon;
Fructus Jujubae: nature and flavor are sweet, temperature, GUIXIN, spleen, stomach warp; There is tonifying the spleen and stomach, replenishing QI and blood, the merit of tranquilizing mind; Modern medicine study shows: in Fructus Jujubae, contain the nutritional labelings such as protein, fat, saccharide, carotene, vitamin B, vitamin C, Citrin and calcium, phosphorus, ferrum and cyclic adenosine monophosphate, can, for sperm development process provides sufficient nutrition supply, the treatment of male sterility be played an important role;
Sanguis cervi: nature and flavor are sweet, salty, temperature; There is tonify deficiency, nourish blood, the merit of benefit essence; Modern medicine study shows, Sanguis cervi can obviously increase the weight of gonadal tissue, increases the sex hormones secretion of human body, to deficiency of kidney-essence, and sterility and infertility, sexual impotence erectile problem, the sexual disorders such as seminal emission premature ejaculation have good action;
Folic acid: be the synthetic essential material of DNA, high in always than blood plasma at semen Folic Acid, when in males when folic acid concentration deficiency, motility of sperm can decline, and is unfavorable for successfully becoming pregnant;
Taurine: the ability that can strengthen cell membrane antioxidation, free radical resisting damage and antiviral damage; Taurine and vitamin E, vitamin C, carotenoid are the same with some polyphenol compounds, have the effect of Scavenger of ROS free radical; Taurine can promote the growth of sexual cell, improves the speed that spermatid forms; The interaction energy of the Scavenger of ROS free radical of taurine and anti peroxidation of lipid damage prevents the lipid peroxidation of Ejaculated sperm cells film, keeps the mobility of eupyrene sperm; Taurine can, by improving in testis and active protection sexual cell and the sperm of spermatogenesis relevant enzyme, be strengthened sexual cell energy metabolism, promotes generation and the maturation of sperm, improves the oxidation resistance of testis tissue; Taurine is one of the abundantest free amino acid of content in reproduction of male animal gland and genitals;
Fructose: being mainly derived from the secretion of seminal vesicle in males, is the main sugar of seminal fluid, is one of important nutritional labeling of sperm, sperm fructose content reduces or is not enough, causes sperm motility energy deficiency, so that can not become pregnant;
Coenzyme Q10: can human activin cell and the nutrition of cellular energy, be converted in mitochondrion at nutrient substance in the process of energy and play an important role; Coenzyme Q10, as a kind of antioxidant and promoter, can be protected oxygen free radical injury sperm, also can stablize spermatic flagellum; Peroxide injury is one of major reason causing sperm quality decline, coenzyme Q10 is a kind of fat-soluble antioxidant being present in mitochondrion, have obvious lipoid peroxidization resistant, its level in refining and sperm has material impact to the anti-oxidative damage ability of male reproductive system; Exogenous supplementary coenzyme Q10 is conducive to improve sperm quality, improves infertile patients fertility.
The biological state type protein-zinc of the present invention and albumen selenium participate in and synthetic, the formation of sperm, the sperm of protection prostaglandin are breathed a series of physiological and biochemical procedures of energy supply, also there is immunomodulating simultaneously, improve enzyme activity, increase antimicrobial factors in prostate, remove the effects such as free radical; The active substance Lepidinm meyenii Walp alkene containing in Lepidinm meyenii Walp and Lepidinm meyenii Walp amide have the sexual function of promotion, improve sperm quantity and enliven the effect of ability; The energy metabolism of sperm can be strengthened and protect to L-carnitine, fructose, citric acid, coenzyme Q10 and vitamin C protection oxygen free radical injury sperm, and folic acid can promote the ripe of sperm and improve its function, Supplement of folic acid in zinc supplement, can improve sperm quality; Sanguis cervi can promote sex hormones secretion, and Fructus Jujubae can provide sufficient nutrition supply for sperm development process, and Cordyceps militaris (L.) Link. can effectively strengthen motility of sperm, extends its life span; Various compositions are had complementary advantages, and all medicines share, and play synergism.
The present invention is directed to the deficiency that existing spermatogenesis medicine exists, reasonable recipe, suitably coordinates multi-medicament, utilize its mutual synergism, improve curative effect, to adapt to the treatment requirement of the complicated state of an illness, reduce untoward reaction, evident in efficacy lasting, absorb fast, prove effective rapidly, effect is strong, nonirritant, safe and reliable, take simply, can effectively promote spermatogenesis, improving sperm survival rate, strengthen the energy of sperm, is the poor active drug of oligoasthenospermia, sperm quality that treatment a variety of causes causes.Treat altogether 5730 examples, total effective rate reaches 95.6%.
(4) detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited thereto, and the preparation method in embodiment is conventional preparation method, no longer describes in detail.
Embodiment 1:
The medicine of this treatment male oligoasthenospermia, raising sperm quality, its active component is made up of the raw material of following weight: 25 kilograms of L-carnitines, 26 kilograms of Lepidinm meyenii Walp, 25 kilograms of Cordyceps militaris (L.) Link., 26 kilograms of Zinc-enriched selenium-enriched dried whole-eggs, 10 kilograms of vitamin Cs, 0.3 kilogram of citric acid, 25 kilograms, Fructus Jujubae, 15 kilograms of Sanguis cervi, 0.2 kilogram, folic acid, 0.05 kilogram of taurine, 1 kilogram, fructose, coenzyme Q10 are 0.05 kilogram;
I) preparation method of Zinc-enriched selenium-enriched dried whole-egg, adopt following steps:
(1) in common egg feedstuff per ton, add zinc sulfate, zinc oxide or the zinc gluconate of 1500g, the sodium selenite of 18g, after stirring, feed laying hen with it, feed and collect the egg that laying hen produces after 7 days, be Zinc-enriched selenium-enriched egg, now the zinc Se content in Zinc-enriched selenium-enriched egg be common egg 2-10 doubly;
(2) Zinc-enriched selenium-enriched egg cleans through egg automatic rinser, washes away surperficial dust and impurity;
(3) after egg is shelled, egg liquid is stirred, filters to remove the impurity such as scrambled egg shell, faciola, membrane of yolk, egg shell membrane, make egg liquid structural state even, filter out impurities for more effective, except with mechanical filter, sieve with 20 order dusting covers again, so that technique carries out and improve end product quality smoothly;
(4) at temperature 64-65 DEG C, the egg liquid after filtering is carried out to pasteurize, the time is 5-8min, to kill escherichia coli and other miscellaneous bacterias, as large in egg liquid viscosity, can add a small amount of sterilized water, stirs, then carries out pasteurize;
(5) use high-pressure pump under the pressure of 15-25MPa the egg liquid through pasteurize, be the droplet of atomization shape through nozzle ejection, droplet, with entering drying tower through the hot blast of air air filter and heater heating, carries out heat exchange in drying tower, and egg liquid is dried to powdered egg powder; During spraying is dry, the control of temperature is: before general spraying, the temperature of drying tower, at 120-140 DEG C, drops to 60-70 DEG C after injection, in spray process, hot blast temperature is controlled at 150-200 DEG C, and powdered egg temperature is at 60-80 DEG C. and the color of powdered egg, taste are normal like this, and water content could conformance with standard;
(6) in order to make dried powdered egg instant, need to be by dry again after dry powdered egg moisture regain, dry in the air cool rear respectively through three layers of sieve, ground floor is 40 mesh sieves, the second layer is 60 mesh sieves, the 3rd layer is 60 mesh sieves, obtains Zinc-enriched selenium-enriched dried whole-egg after sieving, the content >=1.5mg/kg of the content >=45mg/kg of zinc, selenium in Zinc-enriched selenium-enriched dried whole-egg;
The preparation method of the medicine of this treatment male oligoasthenospermia, raising sperm quality is: take raw material by above-mentioned weight, make the tablet of 1g/ sheet with the conventional preparation method of Chinese medicine.
Usage and dosage: oral, every day 3 times, each 4.
Embodiment 2:
The medicine of this treatment male oligoasthenospermia, raising sperm quality, its active component is made up of the raw material of following weight: 1 kilogram of L-carnitine, 1 kilogram of Lepidinm meyenii Walp, 1 kilogram of Cordyceps militaris (L.) Link., 1 kilogram of Zinc-enriched selenium-enriched dried whole-egg, 1 kilogram of vitamin C, 0.1 kilogram of citric acid, 1 kilogram, Fructus Jujubae, 1 kilogram of Sanguis cervi, 0.01 kilogram, folic acid, 0.01 kilogram of taurine, 0.5 kilogram, fructose, coenzyme Q10 are 0.01 kilogram.
Preparation method and usage and dosage are with embodiment 1.
Embodiment 3:
The medicine of this treatment male oligoasthenospermia, raising sperm quality, its active component is made up of the raw material of following weight: 50 kilograms of L-carnitines, 50 kilograms of Lepidinm meyenii Walp, 50 kilograms of Cordyceps militaris (L.) Link., 50 kilograms of Zinc-enriched selenium-enriched dried whole-eggs, 0 kilogram of Catergen, 0.5 kilogram of citric acid, 50 kilograms, Fructus Jujubae, 30 kilograms of Sanguis cervi, 0.4 kilogram, folic acid, 0.1 kilogram of taurine, 1.5 kilograms, fructose, coenzyme Q10 are 0.1 kilogram.
Preparation method and usage and dosage are with embodiment 1.
Embodiment 4:
The medicine of this treatment male oligoasthenospermia, raising sperm quality, its active component is made up of the raw material of following weight: 7 kilograms of L-carnitines, 21 kilograms of Lepidinm meyenii Walp, 44 kilograms of Cordyceps militaris (L.) Link., 45 kilograms of Zinc-enriched selenium-enriched dried whole-eggs, 3 kilograms of vitamin Cs, 0.2 kilogram of citric acid, 6 kilograms, Fructus Jujubae, 20 kilograms of Sanguis cervi, 0.05 kilogram, folic acid, 0.03 kilogram of taurine, 0.7 kilogram, fructose, coenzyme Q10 are 0.09 kilogram;
I) preparation method of Zinc-enriched selenium-enriched dried whole-egg, adopt following steps:
(1) in common egg feedstuff per ton, add zinc sulfate, zinc oxide or the zinc gluconate of 1500g, the sodium selenite of 18g, after stirring, feed laying hen with it, feed and collect the egg that laying hen produces after 7 days, be Zinc-enriched selenium-enriched egg, now the zinc Se content in Zinc-enriched selenium-enriched egg be common egg 2-10 doubly;
(2) Zinc-enriched selenium-enriched egg cleans through egg automatic rinser, washes away surperficial dust and impurity;
(3) after egg is shelled, egg liquid is stirred, filters to remove the impurity such as scrambled egg shell, faciola, membrane of yolk, egg shell membrane, make egg liquid structural state even, filter out impurities for more effective, except with mechanical filter, sieve with 20 order dusting covers again, so that technique carries out and improve end product quality smoothly;
(4) at temperature 64-65 DEG C, the egg liquid after filtering is carried out to pasteurize, the time is 5-8min, to kill escherichia coli and other miscellaneous bacterias, as large in egg liquid viscosity, can add a small amount of sterilized water, stirs, then carries out pasteurize;
(5) use high-pressure pump under the pressure of 15-25MPa the egg liquid through pasteurize, be the droplet of atomization shape through nozzle ejection, droplet, with entering drying tower through the hot blast of air air filter and heater heating, carries out heat exchange in drying tower, and egg liquid is dried to powdered egg powder; During spraying is dry, the control of temperature is: before general spraying, the temperature of drying tower, at 120-140 DEG C, drops to 60-70 DEG C after injection, in spray process, hot blast temperature is controlled at 150-200 DEG C, and powdered egg temperature is at 60-80 DEG C. and the color of powdered egg, taste are normal like this, and water content could conformance with standard;
(6) in order to make dried powdered egg instant, need to be by dry again after dry powdered egg moisture regain, dry in the air cool rear respectively through three layers of sieve, ground floor is 40 mesh sieves, the second layer is 60 mesh sieves, the 3rd layer is 60 mesh sieves, obtains Zinc-enriched selenium-enriched dried whole-egg after sieving, the content >=1.5mg/kg of the content >=45mg/kg of zinc, selenium in Zinc-enriched selenium-enriched dried whole-egg;
The preparation method of the medicine of this treatment male oligoasthenospermia, raising sperm quality is: take raw material by above-mentioned weight, make the electuary of 15g/ bag with the conventional preparation method of Chinese medicine.
Usage and dosage: with mixing in water for oral taking, every day 2 times, each 1 bag.
Embodiment 5:
The medicine of this treatment male oligoasthenospermia, raising sperm quality, its active component is made up of the raw material of following weight: 15 kilograms of L-carnitines, 43 kilograms of Lepidinm meyenii Walp, 8 kilograms of Cordyceps militaris (L.) Link., 39 kilograms of Zinc-enriched selenium-enriched dried whole-eggs, 6 kilograms of vitamin Cs, 0.4 kilogram of citric acid, 16 kilograms, Fructus Jujubae, 25 kilograms of Sanguis cervi, 0.1 kilogram, folic acid, 0.04 kilogram of taurine, 0.9 kilogram, fructose, coenzyme Q10 are 0.08 kilogram.
Preparation method and usage and dosage are with embodiment 4.
Embodiment 6:
The medicine of this treatment male oligoasthenospermia, raising sperm quality, its active component is made up of the raw material of following weight: 35 kilograms of L-carnitines, 16 kilograms of Lepidinm meyenii Walp, 41 kilograms of Cordyceps militaris (L.) Link., 11 kilograms of Zinc-enriched selenium-enriched dried whole-eggs, 17 kilograms of vitamin Cs, 0.1 kilogram of citric acid, 22 kilograms, Fructus Jujubae, 28 kilograms of Sanguis cervi, 0.3 kilogram, folic acid, 0.08 kilogram of taurine, 1.3 kilograms, fructose, coenzyme Q10 are 0.06 kilogram.
Preparation method and usage and dosage are with embodiment 4.
Embodiment 7:
The medicine of this treatment male oligoasthenospermia, raising sperm quality, its active component is made up of the raw material of following weight: 42 kilograms of L-carnitines, 5 kilograms of Lepidinm meyenii Walp, 33 kilograms of Cordyceps militaris (L.) Link., 4 kilograms of Zinc-enriched selenium-enriched dried whole-eggs, 12 kilograms of vitamin Cs, 0.2 kilogram of citric acid, 33 kilograms, Fructus Jujubae, 5 kilograms of Sanguis cervi, 0.4 kilogram, folic acid, 0.06 kilogram of taurine, 1.1 kilograms, fructose, coenzyme Q10 are 0.07 kilogram;
I) preparation method of Zinc-enriched selenium-enriched dried whole-egg, adopt following steps:
(1) in common egg feedstuff per ton, add zinc sulfate, zinc oxide or the zinc gluconate of 1500g, the sodium selenite of 18g, after stirring, feed laying hen with it, feed and collect the egg that laying hen produces after 7 days, be Zinc-enriched selenium-enriched egg, now the zinc Se content in Zinc-enriched selenium-enriched egg be common egg 2-10 doubly;
(2) Zinc-enriched selenium-enriched egg cleans through egg automatic rinser, washes away surperficial dust and impurity;
(3) after egg is shelled, egg liquid is stirred, filters to remove the impurity such as scrambled egg shell, faciola, membrane of yolk, egg shell membrane, make egg liquid structural state even, filter out impurities for more effective, except with mechanical filter, sieve with 20 order dusting covers again, so that technique carries out and improve end product quality smoothly;
(4) at temperature 64-65 DEG C, the egg liquid after filtering is carried out to pasteurize, the time is 5-8min, to kill escherichia coli and other miscellaneous bacterias, as large in egg liquid viscosity, can add a small amount of sterilized water, stirs, then carries out pasteurize;
(5) use high-pressure pump under the pressure of 15-25MPa the egg liquid through pasteurize, be the droplet of atomization shape through nozzle ejection, droplet, with entering drying tower through the hot blast of air air filter and heater heating, carries out heat exchange in drying tower, and egg liquid is dried to powdered egg powder; During spraying is dry, the control of temperature is: before general spraying, the temperature of drying tower, at 120-140 DEG C, drops to 60-70 DEG C after injection, in spray process, hot blast temperature is controlled at 150-200 DEG C, and powdered egg temperature is at 60-80 DEG C. and the color of powdered egg, taste are normal like this, and water content could conformance with standard;
(6) in order to make dried powdered egg instant, need to be by dry again after dry powdered egg moisture regain, dry in the air cool rear respectively through three layers of sieve, ground floor is 40 mesh sieves, the second layer is 60 mesh sieves, the 3rd layer is 60 mesh sieves, obtains Zinc-enriched selenium-enriched dried whole-egg after sieving, the content >=1.5mg/kg of the content >=45mg/kg of zinc, selenium in Zinc-enriched selenium-enriched dried whole-egg;
The preparation method of the medicine of this treatment male oligoasthenospermia, raising sperm quality is: take raw material by above-mentioned weight, make the capsule of 0.5g/ grain with the conventional preparation method of Chinese medicine.
Usage and dosage: oral, every day 3 times, each 4.
Embodiment 8:
The medicine of this treatment male oligoasthenospermia, raising sperm quality, its active component is made up of the raw material of following weight: 20 kilograms of L-carnitines, 45 kilograms of Lepidinm meyenii Walp, 19 kilograms of Cordyceps militaris (L.) Link., 18 kilograms of Zinc-enriched selenium-enriched dried whole-eggs, 10 kilograms of vitamin Cs, 0.4 kilogram of citric acid, 42 kilograms, Fructus Jujubae, 10 kilograms of Sanguis cervi, 0.2 kilogram, folic acid, 0.09 kilogram of taurine, 1.2 kilograms, fructose, coenzyme Q10 are 0.02 kilogram.
Preparation method and usage and dosage are with embodiment 7.
Embodiment 9:
The medicine of this treatment male oligoasthenospermia, raising sperm quality, its active component is made up of the raw material of following weight: 30 kilograms of L-carnitines, 32 kilograms of Lepidinm meyenii Walp, 14 kilograms of Cordyceps militaris (L.) Link., 29 kilograms of Zinc-enriched selenium-enriched dried whole-eggs, 8 kilograms of vitamin Cs, 0.3 kilogram of citric acid, 48 kilograms, Fructus Jujubae, 12 kilograms of Sanguis cervi, 0.15 kilogram, folic acid, 0.07 kilogram of taurine, 0.8 kilogram, fructose, coenzyme Q10 are 0.04 kilogram.
Preparation method and usage and dosage are with embodiment 7.
Vitamin C in above-described embodiment 1-9 also can replace with Fructus Rosae Normalis; In every 100 grams of Fructus Rosae Normalis fresh fruits, ascorbic content is 841.58～3541.13 milligrams, and vitamin content is high, can be drug provision vitamin C of the present invention.
Clinical observation:
(1) clinical data:
In order to verify the curative effect of this medicine, the inventor from 2008 so far, successively 5730 of outpatient clinic routine oligoasthenospermia disease patients are carried out to clinical verification, age 23-40 year, 30 ± 2 years old mean age, course of disease 2-9, average 4 ± 1.4 years, wherein oligospermia 1190 examples, azoospermia 1430 examples, oligoasthenospermia disease 3110 examples.
(2) diagnostic criteria:
Man and wife lives together more than 1 year, and sexual life is normal, does not take any contraceptives and sterile, gets rid of on inspection wife's side factor person.Semen efamination refers to extremely: 1. sperm concentration <60 × 10
9/ L; 2. motility of sperm a+b level <30% or a level <10%; 3. sperm motility rate <60%, above three possess one and can make a definite diagnosis.
(3) Therapeutic Method:
The present invention treats male oligoasthenospermia, improves the medicinal tablet 1g/ sheet of sperm quality, oral, every day 3 times, each 4; The present invention treats male oligoasthenospermia, improves the medicine instant 15g/ bag of sperm quality, with mixing in water for oral taking, and every day 2 times, each 1 bag; The present invention treats male oligoasthenospermia, improves the medicine capsule 0.5g/ grain of sperm quality, oral, every day 3 times, each 4.
During treatment, patient cuts out other drug, ban on opium-smoking and the opium trade wine, tired, avoid work in hot environment and hot water bathing, avoid industrial pollution, lonizing radiation and electromagnetic wave, wear the loose clothing of cotton, notes nutritive equilibrium, and advise spouse of patient to be extraordinarily concerned about, to encourage, to alleviate patient's pressure, to heighten one's confidence.Follow up a case by regular visits to wife's patient situation of becoming pregnant.
(4) curative effect determinate standard:
Criterion of therapeutical effect is according to World Health Organization (WHO) (WHO) " infertile couples standard checks and diagnosis handbook ", and in reference " new Chinese medicine guideline of clinical investigations ", relevant criterion of therapeutical effect is evaluated.
Clinical cure: sperm concentration>=20 × 10 after oligospermia treatment
9/ L, azoospermia motility of sperm a level>=25% or a+b level>=50%, or wife's side pregnancy after treatment.
Effective: after oligospermia treatment, sperm concentration promotes >=50%, the lifting >=25% of azoospermia motility of sperm a+b level or a level promote >=12.5%, but do not reach normal index.
Effective: after oligospermia treatment, sperm concentration promotes >=15%, after azoospermia treatment, motility of sperm a+b level or a level promote >=5%;
Invalid: after treatment, sperm concentration promotes < 15% and motility of sperm lifting < 5% or unchanged.
(5) before and after treatment, each group curative effect is in table 1, and before and after treatment, the seminal parameters of each group is relatively in table 2.
Each group curative effect before and after table 1 treatment
| Group | N | Cure | Effective | Effectively | Invalid | Total effective rate (%) |
| Oligospermia group | 1190 | 795 | 225 | 114 | 56 | 95.3 |
| Azoospermia group | 1430 | 985 | 245 | 137 | 63 | 95.6 |
| Oligoasthenospermia disease group | 3110 | 2026 | 632 | 322 | 130 | 95.8 |
| Add up to | 5730 | 3806 | 1102 | 573 | 249 | 95.6 |
The seminal parameters comparison of each group before and after table 2 treatment
Model case:
Case 1: Lee, man, 33 years old.Marry and within 3 years, fail impregnation, first visit on October 2 in 2008, its lover checks that through every training he or she carries out seminal fluid routine test, is diagnosed as oligospermia without abnormal.Take the made medicinal tablet 1g/ of the embodiment of the present invention 1 sheet, oral, every day 3 times, each 4; Within 2008, December is examined on the 18th again, and seminal fluid routine examination, reaches normal value; Further consultation inspection on January 23 in 2009, all are normal, drug withdrawal; Effect of follow-up visit by telephone, its wife of in December, 2009 is pregnant.
Case 2: Wang, male, 30 years old.Marry and within 5 years, fail impregnation, first visit on October 24 in 2010, its wife checks without abnormal, the eumenorrhea usually.He or she on inspection, is oligoasthenospermia disease, seminal fluid routine test: semen volume 1.5ml, sperm concentration 10.63 × 10
9/ L, a level 10.31%, a+b level 25.35%, takes the made medicine instant 15g/ of the present embodiment 4 bag, and with mixing in water for oral taking, every day 2 times, each 1 bag, on January 3rd, 2011 examines again, seminal fluid routine test: semen volume 2.5ml, sperm concentration 17.31 × 10
9/ L, a level 13.21%, a+b level 30.64%; Further consultation on February 18 in 2011, seminal fluid routine test: semen volume 4.5ml, sperm concentration 25.62 × 10
9/ L, a level 25.57%, a+b level 39.83%, drug withdrawal; Effect of follow-up visit by telephone, in June, 2011, its wife was pregnant.
Case 3: poplar, man, 28 years old.Marry 3 years sterile.First visit on March 20 in 2010, state of an illness diagnosis: azoospermia, motility of sperm extreme difference, sperm concentration 35.64 × 10
9/ L, a level 7.35%, a+b level 21.34%, takes the made medicine capsule 0.5g/ of the present embodiment 7 grain, oral, every day 3 times, each 4, after 2 months, sperm concentration 57.63 × 10
9/ L, a level 26.58%, a+b level 39.82%, evident in efficacy.
Claims (6)
1. a medicine for the treatment of male oligoasthenospermia, raising sperm quality, is characterized in that: its active component is made up of the raw material of following parts by weight: L-carnitine 1-50 part, Lepidinm meyenii Walp 1-50 part, Cordyceps militaris (L.) Link. 1-50 part, Zinc-enriched selenium-enriched dried whole-egg 1-50 part, vitamin C 0.001-35 part, citric acid 0.1-0.5 part, Fructus Jujubae 1-50 part, Sanguis cervi 1-30 part, folic acid 0.001-1 part, taurine 0.004-0.2 part, fructose 0.5-1.5 part, coenzyme Q10 are 0.004-2 part.
2. a kind of medicine for the treatment of male oligoasthenospermia, improving sperm quality according to claim 1, is characterized in that: the preparation method of described Zinc-enriched selenium-enriched dried whole-egg, comprises the steps:
(1) in common egg feedstuff per ton, add the zinc source additive of 500-3000g, the selenium source additive of 5-30g, after stirring, feed laying hen with it, feed and collect the egg that laying hen produces after 7 days, be i.e. Zinc-enriched selenium-enriched egg;
(2) Zinc-enriched selenium-enriched Ovum Gallus domesticus album is washed, washed away surperficial dust and impurity;
(3) after egg is shelled, egg liquid is stirred, filters to remove impurity, and then sieve with 20 order dusting covers;
(4) at temperature 64-65 DEG C, the egg liquid after filtering is carried out to pasteurize, the time is 5-8min;
(5) use high-pressure pump under the pressure of 15-25MPa the egg liquid through pasteurize, be the droplet of atomization shape through nozzle ejection, droplet, with entering drying tower through the hot blast of air air filter and heater heating, carries out heat exchange in drying tower, and egg liquid is dried to powdered egg powder.
(6) dry again after powdered egg moisture regain that will be dry, dry in the air that cool rear ground floor is 40 mesh sieves respectively through three layers of sieve, the second layer is 60 mesh sieves, the 3rd layer is 60 mesh sieves, obtains Zinc-enriched selenium-enriched dried whole-egg after sieving.
3. a kind of medicine for the treatment of male oligoasthenospermia, improving sperm quality according to claim 2, is characterized in that: described zinc source additive is zinc sulfate, zinc oxide or zinc gluconate.
4. a kind of medicine for the treatment of male oligoasthenospermia, improving sperm quality according to claim 2, is characterized in that: described selenium source additive is selenocarrageenan, sodium selenite or selenomethionine.
5. a kind of medicine for the treatment of male oligoasthenospermia, improving sperm quality according to claim 1 and 2, is characterized in that: the content >=45mg/kg of zinc, the content >=1.5mg/kg of selenium in described Zinc-enriched selenium-enriched dried whole-egg.
6. a kind of medicine for the treatment of male oligoasthenospermia, improving sperm quality according to claim 1, is characterized in that: the dosage form of the medicine of described treatment male oligoasthenospermia, raising sperm quality is tablet, electuary or capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410240400.XA CN104083468B (en) | 2014-05-31 | 2014-05-31 | A kind of medicine treating male oligoasthenospermia, raising sperm quality |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410240400.XA CN104083468B (en) | 2014-05-31 | 2014-05-31 | A kind of medicine treating male oligoasthenospermia, raising sperm quality |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104083468A true CN104083468A (en) | 2014-10-08 |
| CN104083468B CN104083468B (en) | 2016-06-29 |
Family
ID=51631296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410240400.XA Active CN104083468B (en) | 2014-05-31 | 2014-05-31 | A kind of medicine treating male oligoasthenospermia, raising sperm quality |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104083468B (en) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104605352A (en) * | 2015-01-23 | 2015-05-13 | 丸永贸易（上海）有限公司 | Maca and roxburgh rose nutrition composition for promoting body blood circulation and warmly invigorating kidney yang as well as preparation method and application thereof |
| CN105596885A (en) * | 2016-01-14 | 2016-05-25 | 梁晓会 | Medicine for treating male oligozoospermia and improving semen quality and preparation method of medicine |
| CN105854007A (en) * | 2016-04-26 | 2016-08-17 | 德立唯（北京）生物科技有限公司 | Composition for treating male oligozoospermia and improving semen quality as well as preparation method and application thereof |
| CN106578281A (en) * | 2016-12-30 | 2017-04-26 | 贝克尔（天津）药业有限公司 | Pressed candy for improving vitality of male sperms, and production method thereof |
| CN106668507A (en) * | 2016-12-29 | 2017-05-17 | 昭远制药(上海)有限公司 | Medicine for curing male infertility and preparation method thereof |
| CN107242550A (en) * | 2017-06-29 | 2017-10-13 | 上海复旦奥医医学科技有限公司 | A kind of male sterility tailored version clinical nutrition formula and preparation method thereof |
| CN108041588A (en) * | 2017-12-08 | 2018-05-18 | 冯纪敏 | A kind of composition containing trehalose and its application |
| CN108379446A (en) * | 2018-03-30 | 2018-08-10 | 上海金城药业有限公司 | Co-enzyme Q 10 formulations and preparation method thereof with auxiliary treatment male's teen bra |
| CN109172804A (en) * | 2018-11-22 | 2019-01-11 | 量子高科(中国)生物股份有限公司 | It is a kind of to improve spermatozoon activity, improving infertile composition and preparation method thereof |
| CN109645497A (en) * | 2018-12-28 | 2019-04-19 | 丽睿客信息科技（北京）有限公司 | A kind of composition and preparation method thereof improving male fertility |
| CN110151898A (en) * | 2019-05-29 | 2019-08-23 | 山东腾贵医药有限公司 | It is a kind of improve male fertility composition and its application |
| CN110302358A (en) * | 2019-08-07 | 2019-10-08 | 广州昊森医药科技发展有限公司 | Improve the composition of human sperm's activity and quality |
| CN110420312A (en) * | 2019-05-29 | 2019-11-08 | 山东腾贵医药有限公司 | A kind of compound formulation that treating lack of quantity of spermatic fluid and preparation method |
| CN111375050A (en) * | 2020-04-17 | 2020-07-07 | 山东新稀宝股份有限公司 | Preparation method and application of zinc-rich egg peptide powder composition for improving male fertility |
| CN113995140A (en) * | 2021-11-08 | 2022-02-01 | 欣安贝药业科技盐城有限公司 | Preparation method of L-carnitine cordyceps militaris compound powder |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1473594A (en) * | 2003-07-01 | 2004-02-11 | 华中科技大学 | Extract of Maka root |
| CN101167735A (en) * | 2006-10-27 | 2008-04-30 | 黄胜先 | Medicine for improving sperm quality and treating man's sterility |
| WO2010127297A1 (en) * | 2009-05-01 | 2010-11-04 | Parviz Gharagozloo | Treating male infertility secondary to sperm oxidative stress |
| CN102204645A (en) * | 2011-06-22 | 2011-10-05 | 武汉回盛生物科技有限公司 | Compound premixed feed for breeding pigs and preparation method thereof |
-
2014
- 2014-05-31 CN CN201410240400.XA patent/CN104083468B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1473594A (en) * | 2003-07-01 | 2004-02-11 | 华中科技大学 | Extract of Maka root |
| CN101167735A (en) * | 2006-10-27 | 2008-04-30 | 黄胜先 | Medicine for improving sperm quality and treating man's sterility |
| WO2010127297A1 (en) * | 2009-05-01 | 2010-11-04 | Parviz Gharagozloo | Treating male infertility secondary to sperm oxidative stress |
| CN102204645A (en) * | 2011-06-22 | 2011-10-05 | 武汉回盛生物科技有限公司 | Compound premixed feed for breeding pigs and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| ZHZZWM2012: "精活速牌复合营养素", 《HTTP://WWW.DOCIN.COM/P-739438779.HTML》 * |
| 余龙江等: "玛咖的植物学及其药理作用研究概况", 《天然产物研究与开发》 * |
| 蔡永敏等: "《最新中药药理与临床应用》", 31 January 1999, 华夏出版社 * |
| 赵振宇等: "牛磺酸药理作用的研究新进展", 《中国医院药学杂志》 * |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104605352A (en) * | 2015-01-23 | 2015-05-13 | 丸永贸易（上海）有限公司 | Maca and roxburgh rose nutrition composition for promoting body blood circulation and warmly invigorating kidney yang as well as preparation method and application thereof |
| CN105596885A (en) * | 2016-01-14 | 2016-05-25 | 梁晓会 | Medicine for treating male oligozoospermia and improving semen quality and preparation method of medicine |
| CN105854007A (en) * | 2016-04-26 | 2016-08-17 | 德立唯（北京）生物科技有限公司 | Composition for treating male oligozoospermia and improving semen quality as well as preparation method and application thereof |
| CN106668507A (en) * | 2016-12-29 | 2017-05-17 | 昭远制药(上海)有限公司 | Medicine for curing male infertility and preparation method thereof |
| CN106578281A (en) * | 2016-12-30 | 2017-04-26 | 贝克尔（天津）药业有限公司 | Pressed candy for improving vitality of male sperms, and production method thereof |
| CN107242550A (en) * | 2017-06-29 | 2017-10-13 | 上海复旦奥医医学科技有限公司 | A kind of male sterility tailored version clinical nutrition formula and preparation method thereof |
| CN108041588A (en) * | 2017-12-08 | 2018-05-18 | 冯纪敏 | A kind of composition containing trehalose and its application |
| CN108379446B (en) * | 2018-03-30 | 2021-05-04 | 上海金城素智药业有限公司 | Coenzyme Q10 preparation for adjuvant treatment of male oligospermia and preparation method thereof |
| CN108379446A (en) * | 2018-03-30 | 2018-08-10 | 上海金城药业有限公司 | Co-enzyme Q 10 formulations and preparation method thereof with auxiliary treatment male's teen bra |
| CN109172804A (en) * | 2018-11-22 | 2019-01-11 | 量子高科(中国)生物股份有限公司 | It is a kind of to improve spermatozoon activity, improving infertile composition and preparation method thereof |
| CN109645497A (en) * | 2018-12-28 | 2019-04-19 | 丽睿客信息科技（北京）有限公司 | A kind of composition and preparation method thereof improving male fertility |
| CN110151898A (en) * | 2019-05-29 | 2019-08-23 | 山东腾贵医药有限公司 | It is a kind of improve male fertility composition and its application |
| CN110420312A (en) * | 2019-05-29 | 2019-11-08 | 山东腾贵医药有限公司 | A kind of compound formulation that treating lack of quantity of spermatic fluid and preparation method |
| CN110302358A (en) * | 2019-08-07 | 2019-10-08 | 广州昊森医药科技发展有限公司 | Improve the composition of human sperm's activity and quality |
| CN111375050A (en) * | 2020-04-17 | 2020-07-07 | 山东新稀宝股份有限公司 | Preparation method and application of zinc-rich egg peptide powder composition for improving male fertility |
| CN113995140A (en) * | 2021-11-08 | 2022-02-01 | 欣安贝药业科技盐城有限公司 | Preparation method of L-carnitine cordyceps militaris compound powder |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104083468B (en) | 2016-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104083468B (en) | A kind of medicine treating male oligoasthenospermia, raising sperm quality | |
| CN105596885A (en) | Medicine for treating male oligozoospermia and improving semen quality and preparation method of medicine | |
| CN103141839A (en) | Maca and fructus hippophae tablet | |
| CN103431392B (en) | Composite marine food for special dietary uses for diabetics | |
| CN109045059A (en) | A kind of anti-aging, the composition for improving male's energy, preparation and the preparation method and application thereof | |
| CN106668507A (en) | Medicine for curing male infertility and preparation method thereof | |
| CN102994346A (en) | Base stock for preparing MACA wine | |
| CN110151715A (en) | A kind of Biocal and preparation method thereof that lactating female is applicable | |
| CN105768108A (en) | Special dietary food suitable for taking of tumor patients | |
| CN105995150A (en) | Egg selenium content improving feed | |
| KR100874859B1 (en) | Manufacturing process of health food whan made of melon seed, the main ingredient | |
| CN106036878A (en) | Special nutritional preparation for repair of male germ cell, and preparation method of nutritional preparation | |
| CN104940241B (en) | A kind of selenium worm grass compound preparation of prevention climacteric metancholia of women | |
| CN101837058B (en) | Medicament for curing leukemia | |
| CN102090637A (en) | Collagen-containing compound nutritious powder | |
| CN101317605B (en) | Novel formulating method for functional milk powder | |
| US20180169071A1 (en) | Nutritional supplement composition | |
| CN103621871A (en) | Compound amino acid health-care product and preparation method thereof | |
| CN101869329B (en) | Life-prolonging cancer-prevention healthcare beverage | |
| CN103798596B (en) | Total nutrient formula food suitable for patients with cardiovascular and cerebrovascular diseases | |
| CN106072252A (en) | Increasing intelligence containing Semen Maydis edible fungi nut encourages nutritional jelly and production method thereof | |
| CN101091720A (en) | Health food with efficacy for preventing osteoporosis and preparation method | |
| CN111165797A (en) | Nutritional energy diet suitable for comprehensive regulation of physical functions of astronauts | |
| CN1240430C (en) | Medicine for preventing and treating chronic exhaustion syndrome and preparing mthod thereof | |
| CN104013853B (en) | A kind of composition of strong kidney kidney tonifying and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |