CN103431392B - Composite marine food for special dietary uses for diabetics - Google Patents
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Abstract
The invention discloses composite marine food for special dietary uses for diabetics. The composite marine food comprises chitosan oligosaccharide, chitosan, astaxanthin, beta-carotene, coenzyme Q10, vitamin C, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B3, vitamin B6, folic acid, vitamin B12, calcium and magnesium as macroelements as well as iron, zinc, iodine, copper, manganese, selenium and chromium as trace elements. The composite marine food for special dietary uses, disclosed by the invention, is novel and comprehensive nutrition food which can comprehensively perfect the nutritional status of diabetics and reinforce the organism immunity of the diabetics, and the chitosan oligosaccharide and other natural active ingredients interact to beneficially control the blood glucose levels of the diabetics, perfect the symptoms of diabetes and reduce the occurrence rate of diabetic complications, so that the food is suitable for long-term use by the diabetics.
Description
Technical field
The invention belongs to nutritious health caring food technology field, be specifically related to a kind of composite marine special dietary food of diabetes patients.
Background technology
Diabetes are one group take hyperglycaemia as the metabolic disease of feature caused by defect of insulin secretion and/or insulin action obstacle.Diabetes and complication very big to the harm of human body, persistent high blood sugar and long-term metabolic are disorderly etc. can cause body tissue's organ, particularly eye, kidney, cardiovascular and neural infringement and dysfunction thereof and exhaustion; Severe patient can cause dehydration, the acute complications such as electrolyte disturbance and acid-base imbalance DKA and Hyperosmotic coma.Diabetes not only reduce the quality of life of patient, also increase the financial burden of country and patient home simultaneously.Since the seventies in last century, along with the quick change of the rapid raising of living standards of the people and life style particularly dietary, China's diabetes prevalence significantly increases.The epidemiologic data display of national 14 provinces and cities 300,000 people in 1980, the illness rate of diabetes is 0.7%.2007-2008, under diabetology branch of Chinese Medical Association tissue, 14 provinces and cities in the whole nation have carried out the epidemiology survey of diabetes.Adult's diabetes prevalence that result shows China more than 20 years old is 9.7%.So the blood glucose control form of China is very severe.
Dietary therapy is the primary measure of all kinds Diabetes Foundation treatment.The principle of dietary therapy is: control total amount of heat and body weight.Diabetes are that a kind of chronic metabolic is sick, according to patient's physical condition, prepare food of special nutrients targetedly, improve the nutrition condition of patient comprehensively, strengthen resistance against diseases, can more effectively auxiliary hyperglycemic and prevent life-threatening complication from occurring.There are clear and definite regulation and perfect standard criterion in European and American developed countries to food of special nutrients, and generally accept for people.China has worked out " Chinese residents dietary guidelines " at present, and revises in 2007 this guide, with " pre-packaged food for special foods label general rule GB13432-2004 " for Main Specification file.In this general rule, special diet is defined as: " for meeting the physiological requirements of some particular patients ', or the nutritional need of some Disease, the food processed specially by special formulation ".The science essence of particular patients ' diet regulation and control is: control regular diet, supplements special diet, strengthens for nutrition, reduces metabolism burden, promotes healthy.
At present, China market there is the food for special foods of diabetes patients, but great majority are all vitamin, mineral matter class and some simple hypoglycemic drugs, more or less all there is unreasonable, the unreasonable and irrational problem of using dosage of arranging in pairs or groups of composition, so the physiological function of diabetic can not be nursed one's health all sidedly, be thus difficult to reach desirable effect.In addition, also can find in patent document to utilize the exploitation coronary heart disease health foods such as chitosan oligosaccharide, shitosan, Co-Q10, marine polysaccharide, such as " sea dietary that patent No. CN201010290744.3 diabetic is special ", but the formula content of this patent is complicated, poor effect, and actual operation is not strong, and its formulation efficacy is verified without zoopery.
Summary of the invention
For above-mentioned problems of the prior art, the present invention provides a kind of composite marine special dietary food of diabetes patients according to the deficiency of the physilogical characteristics of diabetic, nutritional need and conventional dietary thereof, natural active matter and needed by human nutrient can be provided to supplement for diabetic.The chitosan oligosaccharide that described composite marine special dietary food contains, shitosan, astaxanthin, beta carotene, Co-Q10 and vitamin and mineral matter, the nutrition condition of body diabetic can be improved, its physiological function of comprehensive conditioning, plays the effect improving immunity of organisms, improve diabetic symptom.
For achieving the above object, the present invention is achieved by the following technical solutions:
A composite marine special dietary food for diabetes patients, its material composition is as follows, with parts by weight:
Further, described special meal nutritional food also includes linseed oil 50-200 part.
Further, described special meal nutritional food also includes extractive of flax seed 5-20 part.
Further, described special meal nutritional food also includes fucoidin sulfuric ester 25-200 part and L-carnitine-L-tartrate 10-40 part.
Further, the described chitosan oligosaccharide degree of polymerization is 2-15, and molecular weight is less than 5000.
Further, described composite marine special dietary food is capsule, tablet, pulvis, granule, oral liquid or paste.
Present invention also offers the preparation method of the composite marine special dietary food of described diabetes patients, it comprises the following steps: choose above-mentioned each material composition, add above-mentioned material according to the proportioning of described weight portion, after pulverizing and sieving, mix; Control temperature prepares this product content below 60 DEG C, under lucifuge condition, and routine operation obtains pulvis, granule or capsule, and all operations all carries out in clean dried environment.
The another kind of preparation method of the composite marine special dietary food of described diabetes patients, it comprises the following steps: choose above-mentioned each material composition, add above-mentioned material according to the proportioning of described weight portion, material is dropped into vacuum emulsification tank, stir, grind to obtain this product content; Gelatin, glycerine, purified water Hybrid Heating are stirred to gelatin and dissolve obtained softgel shell solution completely, vacuumize degassing, and the insulation of softgel shell solution is to 55 DEG C-60 DEG C; Get foregoing thing and softgel shell solution, compressing, dry obtained soft capsule.
Further, under vacuum is 0.08-0.09MPa, de-bubble is to the greatest extent vacuumized.
Compared with prior art, the major advantage of phase of the present invention and technique effect are:
The present invention is a kind of novel, comprehensive composite marine special dietary food, can improve the physiological function of diabetic, scavenging free radicals comprehensively, improves immunity.
Multiple natural active matter and nutrient combine by the present invention, carry out reasonably combined, the unique effect of each composition can be given full play to, mutual promotion can be played again, complement each other, complementary effect, play more perfect than single component, more comprehensively with powerful effect, reach the requirement of product safety, effective, quality controllable health products.
Chitosan oligosaccharide used in the present invention, shitosan, astaxanthin, beta carotene and Co-Q10 are natural active materials, have hypoglycemic, anti-oxidant, to strengthen immunity of organisms effect; Vitamin simultaneously in invention and the nutrient such as mineral matter are except being the nutrient that generally lacks of China resident, also there is the effect improving diabetic's physiological function, their addition is with reference to Chinese residents Chinese DRIs every day, by the combination of natural active matter and nutrient, the present invention is had to be incorporated multiple different efficacies composition in product, these compositions cooperatively interact, have synergy, can be comprehensively, balancedly diabetic's extra-nutrition.Therefore the functional component of product of the present invention and materials safety high, ediblely having no side effect for a long time, is the ideal nutritional supplement of diabetic.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described, and following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1
Be applicable to the composite marine special dietary food of patients with diabetes mellitus described in the present embodiment, the content of its each material composition is:
The preparation method of described composite marine special dietary food comprises the following steps:
Getting the degree of polymerization is 2-15, and molecular weight is the water-soluble chitosan oligosaccharide 300mg of less than 5000 and shitosan, astaxanthin, beta carotene, Co-Q10, vitamin C, vitamin E, the vitamin D of above-mentioned formula ratio
3, Cobastab
1, Cobastab
2, Cobastab
3, Cobastab
6, folic acid, Cobastab
12, calcium gluconae, zinc lactate, ferrous lactate, magnesium gluconate, manganese citrate, copper gluconate, selenocysteine, nicotinate chromium mix, grind with grinder after adding 80mg linseed oil, afterwards material is dropped into vacuum emulsification tank, stir, grind to obtain this product content by grinder.Gelatin, glycerine, purified water are mixed and heated to certain temperature (75 DEG C) in the ratio of regulation and are stirred to gelatin and dissolve completely, vacuumize degassing 30 minutes (vacuum 0.09MPa), get foregoing thing and softgel shell solution, adopt pressing compressing with soft capsule production equipment, after drying, namely obtain the composite marine special dietary food capsule being applicable to patients with diabetes mellitus.
Introduce the characteristic of each material composition of the present invention below in detail:
Chitosan oligosaccharide: be a kind of completely new product obtained through special biological enzyme technology process by shitosan, its good water solubility, biologically active is high, and heat is low, and is easily absorbed by the body.The function of chitosan oligosaccharide is very powerful, have improve blood pressure, hypoglycemic, suppress fat absorption, row's cholesterol, anti-trioxypurine value, re-scheduling metal ion, inhibition tumor cell, adjustment pH value of human body, promote the effect such as wound healing, regulating intestinal canal and raising immunity.
Shitosan: be that the chitin extensively existed by nature obtains through deacetylation.Shitosan has the immunoregulation effect to body, and the pH value in energy control agent, to alkalescent, improves the utilization rate of insulin, is conducive to preventing and treating diabetes.It also has the function regulating internal system, makes insulin secretion normal, suppresses blood sugar to raise, reduces blood fat.In addition, shitosan can be generated natural metabolin by the lysozyme degraded in organism, has feature that is nontoxic, that can be absorbed completely by organism, therefore has larger superiority with it as medicinal slow release agent.
Astaxanthin: the one being carotenoid is that the mankind find the antioxidant that nature is the strongest up to now, can ultraviolet radiation preventing; strengthen human body energy metabolism, Tumor suppression, suppress diabetes and ephrosis; protection retina and central nervous system, improve immunity.
Beta carotene: be a kind of fat-soluble antioxidant is the approach of current safest replenishing vitamins A.It not only can hypotensive, hypoglycemic, reducing blood lipid, beauty treatment, defaecation and anti-ageing, also there is the ability improving the anti-infective and Tumor suppression growth of immunologic function, PFT, the upper respiratory tract.Have result of study to show, in healthy human blood, the content of beta carotene is very high, and very low in diabetic's blood.Therefore the content of beta carotene has positive effect to prevention diabetes in raising body.
Co-Q10: be a kind of fat-soluble antioxidant, it is one of indispensable important element of human life, its can the nutrition of human activin cell and cellular energy, has to improve body immunity, strengthen anti-oxidant, antitumor, anti-hypertension, delay senility and strengthen the functions such as human activity.By supplementing appropriate Co-Q10, can not only effectively regulate blood sugar amount, realizing blood glucose balance, actively can also remove the toxin destroying islet cells, repairing islet cells, thus effectively improve the generation of diabetic symptom and prevention diabetic complication.
Linseed oil: be a kind of oils being rich in alpha-linolenic acid of being squeezed by linseed, wherein the content of alpha-linolenic acid is 55%.Alpha-linolenic acid is essential fatty acid, can not synthesize in human body, must from external picked-up.The effect that it can promote pancreaticβ-cell excreting insulin and protect insulin stable in blood.The opposing of target cell ginseng insulin can be reduced.When suffering from diabetes, the lipolysis in body is accelerated, and lipid metabolism rate disorderly causes blood fat to increase, and causes vascular sclerosis, the complication such as hyperlipemia, fatty liver, hypertension.Alpha-linolenic acid regulates lipid metabolism in human body, suppresses complication, reduces the probability of acid, ketoacidosis, is of great advantage to each organ of human body and neural protective effect humidification to diabetic.
Extractive of flax seed (commercially available): main active is flax lignan class material.Flax lignan can alleviate various skin problem, consumption health superabundant fats, improves women's premenstrual syndrome, promotes health compressive resistance ability, improves arthritis, reduce cholesterol, atherosclerosis.Flax lignan not only has prevention effect to breast cancer, prostate cancer, menstrual period syndrome, osteoporosis, also to diabetes, stomach and intestine tumor, coronary heart disease, kidney trouble, and the effect that non-oxidizability is useful.
Fucoidin sulfuric ester: also known as fucoidin, algal polysaccharide sulfate, it is specific marine active polysaccharide in brown algae sea-plant (sea-tangle etc.), rare sulfuric ester ionic natural polysaccharide is belonged at occurring in nature, show through great many of experiments and clinical research, have improve immunity, hypoglycemic, anticoagulation, reducing blood lipid, hypotensive, suppress renal failure, the physiologically active such as antitumor.
L-carnitine-L-tartrate: l-cn is the necessary auxiliary substance of a kind of body fat oxidative metabolism.Because content in food is low less with synthetic quantity in body, l-cn lacks, and can produce hyperglycaemia, high fat of blood, angiocardiopathy, fatty liver, male sterility and weak symptom etc.As a kind of nutritional supplement of promotion oxidative cleavage of fatty acids of safe, effective, science, l-cn can reduce body fat, reduces body weight; Reduce serum total cholesterol and triglycerides, increasing serum HDL; Strengthen the ability of cardiac muscle cell's oxidation of fat, reduce the burden of heart during high-intensity exercise; Improve cardiac arrhythmia and don't affect blood pressure; Improve immune function of human body, enhanced machine vitality of subject, fatigue-relieving, delays senility.L-carnitine-L-tartrate is a kind of stable form of l-cn, and the not easily moisture absorption, easily preserves, and has the identical effect with l-cn, and to human non-toxic's side effect.
Vitamin C: be a kind of water soluble vitamin, for guarantee human body metabolic normally carry out with the raising of immunologic function most important.It can not only treat scurvy and hypoferric anemia, prevention gingival atrophy and hemorrhage, and promote the normal synthesis of collagen, its antioxidation can also resist the injury of radical pair cell, improves body immunity.Special for diabetic, vitamin C can strengthen the hypoglycemic activity of insulin and improve the oxidation of glucose; Meanwhile, the hyperglycemia state of diabetic and low insulin level, may cause vitamin C in body, when absorbing, absorbing and transporting, obstacle occurs; In body, vitamin C famine can cause the generation of the diabetic complications such as aneurysm, microaneurysm, retinopathy and ephrosis.
Vitamin D: be a kind of liposoluble vitamin, is mainly used in forming and maintaining the strong of bone, and has humidification to immune system.The D that is deficient in vitamin is harmful to life and health, may cause as the various diseases such as diabetes and complication thereof.Therefore for diabetic, it is very necessary for supplementing appropriate vitamin D.
Vitamin E: be a kind of liposoluble vitamin, also known as tocopherol, is one of topmost antioxidant, can stops the infringement of radical pair vascular wall.Tocopherol can promote that sex hormone is secreted, and man's sperm motility and quantity are increased; Woman's female hormone concentration is increased, improves fecundity, prevention of miscarriage.In addition, vitamin E is a kind of very important vasodilator and anticoagulant, prevention and treatment varication, and solidifying of anti-Hemostatic Oral Liquid, reduces the generation of speckle tissue; Improve blood circulation, protective tissue, reduction cholesterol, preventing hypertension; Improve lipid-metabolism, prevention of arterial is atherosis and coronary heart disease.
Cobastab
1: also known as thiamine or antineuritic vitamin or anti beriberi vitamin, it is not only human energy metabolism, and particularly glycometabolism is necessary, or maintains heart, neural and digestive system normal function is necessary.Its physiological function comprises promotion and grows up, helps digest; Improve mental status; Maintain nerve fiber, muscle, cardiomotility normal.
Cobastab
2: be riboflavin again, its physiological function comprises: participate in affecting biological oxidation and energetic supersession in human body, relevant with the metabolism of carbohydrate, protein, nucleic acid and fat; Participating in the growth metabolism of cell, is the necessary nutrient of injected organism tissue metabolism and reparation; Relevant with mobilization with the absorption of body iron, storage; There is antioxidation biology activity etc.
Cobastab
3: claim nicotinic acid, it does not still maintain the vitamin of digestive system health, is that sex hormone synthesizes indispensable material, is cells activated by insulin agent yet, contributes to preventing and treating diabetes yet.Concerning life is full of the modern of pressure, nicotinic acid maintains effect of nervous system health and the normal operation of brain function, absolutely not can ignore.In addition, it can reduce cholesterol and triglyceride, stimulates circulation, and blood pressure is declined, and has stronger expansion peripheral vessels effect.
Cobastab
6: be body fat and glycometabolic required material, be conducive to the control of blood sugar, alleviate the DPN of diabetes.It is also very close with the relation of vitamin B2, and Vitamin B6 deficiency is often with vitamin B2 symptom.
Folic acid: the one being B family vitamin, contributes to glycemic control, alleviates the DPN of diabetes; Improve function of vascular endothelium, angiocardiopathy preventing.
Cobastab
12: main Physiological Function participates in manufacturing erythrocyte, prevents pernicious anaemia; Safeguard that nervous system is healthy; Exist with the form of coenzyme, the utilization rate of folic acid can be increased, promote the metabolism of carbohydrate, fat and protein; Fat metabolism acid, makes fat, carbohydrate, protein suitably be used by health.
Calcium: be a kind of inorganic salts that people's in-vivo content is maximum, it maintains the normal physiological condition of all cells, as the normal beats of heart; Calcium and magnesium, potassium, sodium plasma keep certain proportion, make nerve, muscle keep normal reaction; Calcium tool regulates the rhythm of the heart, reduces cardiovascular permeability, controls inflammation and the effect such as oedema, maintenance acid-base balance.Diabetic, except metabolism obstacles of blood glucose, also has the metabolism disorder such as vitamin, calcitonin, affects bone metabolism, inspires osteoporosis, so it is extremely important to diabetic to replenish the calcium.
Magnesium: be the indispensable element maintaining human life activity, has and regulates the magical function that N&M is movable, strengthen endurance.In addition, magnesium is also hypertension, high cholesterol, hyperglycaemia " jinx ", contributes to preventing and treating apoplexy, coronary heart disease and diabetes.
Iron: the essential trace element being human body, to the menu of human body now in many aspects, iron participates in transport and the storage of oxygen to iron.The heart, liver, kidney these have height physiological activity ability and biochemical function cell mitochondrial in, the iron of storage is many especially, and mitochondria is cell " energy plants ", and the release of energy participated in directly by iron.Iron can also promote to grow; Increase the resistance to disease; Regulate tissue respiration, prevent fatigue; Form ferroheme, the anaemia that prevention and therapy causes because of iron deficiency; Make the color that skin recovers good.
Zinc: the trace element being needed by human, but can not synthesize in vivo, external food can only be relied on to provide.It is the constituent of the many important enzymes of human body, is also the necessary element of insulin synthesis; It protein and nucleic acid synthesis, safeguard erythrocytic integrality and all play an important role in hematopoiesis, be the key element of enhancing development; It also can improve body immunity.
Manganese: it is relevant with human body different physiological roles, comprises the normal growth and growth that affect bone, the metabolism of impact sugar, must be indispensable in maintenance normal brain activity function.
Selenium: selenium and vitamin E are all antioxidants, and the two complements each other, the aging that can prevent from causing because of oxidation, the hardening of tissue, can to slow down speed of its change at least, has activated immune system, protects cardiovascular and antineoplastic effect; Can regulate glycometabolism, help diabetic to control blood sugar, be necessary trace mineral.Selenium also has detoxicating functions, because selenium and metal have good compatibility.
Chromium: be one of trace element in body, its content in vivo reduces gradually along with the increase at age.Though the requirement of chromium is few, insulin can be helped to promote, and glucose enters intracellular efficiency, is important blood sugar regulator.It contributes to growing, and also has control action to the cholesterol concentration in blood, and the formation of energy atherosclerosis, able person can cause heart disease during shortage.Therefore, take in chromium in appropriate amount, particularly for diabetic and cardiovascular patient, have important effect.
The emphasis of the various functional components in the present invention is different, and various component has been combined together synergistic function, uses more excellent effect preventing and treating to obtain in diabetes and complication thereof than single component.
Shitosan is a kind of natural alkaline polysaccharide, the cationic natural polymer animal origin of a kind of band, itself there is stronger hypoglycemic character, the pH value of diabetic's body fluid can be adjusted to alkalescent by it, improve insulin utilization rate, alleviate the damage of radical pair islet cells, play the effect reducing blood sugar and strengthen sugar tolerance.Shitosan can also promote that intestinal beneficial bacterium is bred, adjustment enteron aisle, and diabetic symptom is eased, and can promotes intestines peristalsis, absorption is with the fat of anion and is excreted, and blood fat is reduced.But due to the HMW of shitosan, shitosan is restricted in the application in hypoglycemic, and chitosan oligosaccharide is by a kind of compound sugar of shitosan through the method such as enzymolysis or acidolysis gained, its physiologically active is similar to shitosan, and compared with shitosan, it is little that it has molecular mass, soluble in water, and be easily absorbed by the body the advantages such as utilization.What chitosan oligosaccharide and shitosan stressed is directly reduce for blood sugar to play a positive role, and effectiveness comparison is direct.
Astaxanthin is that the mankind find the antioxidant that nature is the strongest up to now, energy singlet-oxygen quenching and removing peroxylradicals; This effect outclass other carotenoid and vitamin E, can inhibitory mutagenesis, Cell differentiation inducing activity, anti-oxidant, has the plurality of health care functions such as scavenging free radicals, Cell protection, enhancing immunization, anti-inflammatory, angiocardiopathy preventing and cancer.Therefore the main component that chitosan oligosaccharide, shitosan and astaxanthin are composite marine special dietary food is chosen.As the composite composition of chitosan oligosaccharide, shitosan and astaxanthin, beta carotene, Co-Q10, linseed oil, extractive of flax seed, fucoidin sulfuric ester, L-carnitine-L-tartrate, various vitamin and mineral matter much functionally have similar effect: the effect of anti-oxidant, repair cell, regulate human body sugar and lipid metabolism, reduce blood fat, improve blood pressure, strengthen immunologic function, fatigue-relieving etc.In the present invention, these composite compositions and main component are superimposed and mutually promote, mutually supplement, and can play complementary " monarch " effect, its Be very effective is better than any single component or alone main component.
The interpolation form of mineral matter of the present invention is the organic or inorganic compound of this mineral matter.
" DRIs ", " food enrichment use sanitary standard " (GB14880-1994) that in the present invention, the addition of vitamin and minerals is promulgated with reference to Chinese Soclety of Nutrition in 2000 and " nutrient prime replenisher declare with evaluate specify (trying) " middle " vitamin, mineral types and consumption " specified that on July 1st, 2005, State Food and Drug Administration formally came into effect perform.
The composite marine special dietary food of diabetes patients prepared by the present invention can be made into the various ways such as capsule, tablet, pulvis, granule, oral liquid, paste.
Embodiment 2
Be applicable to the composite marine special dietary food of patients with diabetes mellitus, the content of its each material composition is:
The preparation method of described composite marine special dietary food comprises the following steps:
Getting purity is the flax lignan 10mg of 20% ~ 60% and chitosan oligosaccharide, chitosan oligosaccharide, astaxanthin, beta carotene, Co-Q10, fucoidin sulfuric ester, L-carnitine-L-tartrate, vitamin C, vitamin E, vitamine D3, beta carotene, the Cobastab of above-mentioned formula ratio
1, Cobastab
2, Cobastab
3, Cobastab
6, folic acid, Cobastab
12, calcium gluconae, zinc lactate, ferrous lactate, magnesium gluconate, manganese citrate, copper gluconate, selenocysteine, nicotinate chromium mix; The above-mentioned raw material mixed is added in mixer first to rotate forward and be dry mixed stirring, 10% dextrin starch slurry can be divided to count several times in mixer and carry out wet mixing conjunction, stir continuously, make softwood; Get in above-mentioned softwood feeding oscillating granulator and granulate with 16 eye mesh screens; The particle made is put into baking oven dry, when moisture is below 3%, can drying be stopped, giving free rein to dry in the air cool; Then cross 14 eye mesh screens and carry out whole grain, make the single-size shape this product of the size that meets the requirements.
Embodiment 3, implementation result are tested
Mouse experiment is implemented with the composite marine special dietary food being applicable to patients with diabetes mellitus in embodiment 2.
1, animal grouping: the female NOD mouse 60 do not fallen ill 7 week age, survey fasting blood sugar, mouse is divided at random by blood sugar: (1) control group; (2) chitosan oligosaccharide prevention group (dosage); (3) this product prevention group (dosage).Every only point cage, basal feed is fed, and drinking water made by the cold boiling water of control group, continuous 14 weeks.
The detection of diabetes: surveyed NOD mouse fasting blood-glucose 1 time every 1 week with glucose oxidase method and weigh 1 time, observing and whether have diabetic symptom to occur.When many drinks, diuresis symptom appear in mouse, detect glucose in urine, the glucose in urine person of being positive, and continuous 2 >11.1mmol/L of fasting blood-glucose, be namely diagnosed as glycosuria 22 sick.Onset diabetes rate: the examination criteria according to diabetes calculates.
The pathological observation of pancreas islet: at the end of experiment, often organize and get 7 mouse at random, disconnected neck is put to death, and anatomical isolation pancreas, fixes 8 ~ 12h by 10% neutral formalin immediately, FFPE, the thick section of 5Lm, HE normal dyeing, light Microscopic observation, the pancreas of every mouse from four different levels random observations, 10 pancreas islet, and carries out inflammation of pancreatic islet classification: around islets is without lymphocytic infiltration; 1 grade: the periphery of monocyte infiltration pancreas islet or the islet area of <25% are got involved; 2 grades: 25% ~ 50% islet area is got involved; The islet area of 3 grades: >50% is got involved.
2, experimental result
The change of body weight: before the 2nd week of experiment, the average body weight average of three groups has increase in various degree, and two groups of difference are without conspicuousness; After 4 weeks, the average body weight average of two prevention groups has obvious rising (P<0.05), and this product prevention group is more obvious for the impact of Mouse Weight compared with chitosan oligosaccharide prevention group, the speed declined to the last control group of experiment is obviously greater than two prevention groups, and the Mouse Weight decrease speed of this product prevention group is lower than chitosan oligosaccharide prevention group (P<0.05).In table 1.
The change (g) of table 1 liang group average weight
* dead mouse 1
* dead mouse 2
Experimental result is as shown in table 1, and chitosan oligosaccharide control group blood sugar, in i.e. visible rising in the 2nd week of experiment, obviously increased after the 8th week.And this product prevention group has no significant change in the early stage blood sugar level of experiment compared with before experiment, after 8 weeks, blood sugar level slightly rises, but all the time well below control group (P<0.01), and be better than chitosan oligosaccharide prevention group (P<0.01) in table 2.
The change (mmol/L) of table 2 liang group blood sugar level
* dead mouse 1
* dead mouse 2
To sum up, the present invention is according to the nutritional need of patient, take chitosan oligosaccharide as the composite marine special dietary food of the diabetes patients of primary raw material preparation, not only be conducive to regulating pH value of human body, increase the activity of insulin, increase the synthesis of glycogen, thus contribute to the decline of blood sugar, improve the incidence of diabetic symptom and reduction diabetic complication simultaneously, and with the addition of shitosan, astaxanthin, beta carotene, the multiple active skull cap components such as Co-Q10 and multivitamin and mineral matter, the nutrition condition of diabetic can be improved comprehensively, obvious enhancing resistance against diseases.
Above embodiment only in order to technical scheme of the present invention to be described, but not is limited; Although with reference to previous embodiment to invention has been detailed description, for the person of ordinary skill of the art, still can modify to the technical scheme described in previous embodiment, or equivalent replacement is carried out to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of the present invention's technical scheme required for protection.
Claims (3)
1. a composite marine special dietary food for diabetes patients, is characterized in that it is made up of following material composition, with parts by weight:
The described chitosan oligosaccharide degree of polymerization is 2-15, and molecular weight is less than 5000.
2. the composite marine special dietary food of diabetes patients according to claim 1, is characterized in that: described composite marine special dietary food is capsule, tablet, pulvis, granule, oral liquid or paste.
3. the preparation method of the composite marine special dietary food of diabetes patients according to claim 1, it is characterized in that it comprises the following steps: choose above-mentioned each material composition, material is added according to the proportioning of described weight portion, material is dropped into vacuum emulsification tank, stir, grind to obtain this product content; Gelatin, glycerine, purified water Hybrid Heating are stirred to gelatin and dissolve obtained softgel shell solution completely, and under vacuum is 0.08-0.09MPa, vacuumize de-bubble to the greatest extent, the insulation of softgel shell solution is to 55 DEG C-60 DEG C; Get foregoing thing and softgel shell solution, compressing, dry obtained soft capsule.
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| CN105982922A (en) * | 2015-02-25 | 2016-10-05 | 北京世健联合医学科学研究院（普通合伙） | Composition for treating diabetes and application thereof |
| CN104921228A (en) * | 2015-07-05 | 2015-09-23 | 青岛浩大海洋保健食品有限公司 | Marine functional health beverage with blood glucose reduction function |
| CN106261589A (en) * | 2016-08-04 | 2017-01-04 | 刘良忠 | Special dietary seafood that a kind of applicable patients with chronic diseases is edible and processing method thereof |
| CN106820151A (en) * | 2016-12-22 | 2017-06-13 | 北京康比特体育科技股份有限公司 | A kind of bivalve compound health composition, preparation method and application |
| CN108498563B (en) * | 2018-05-18 | 2020-10-23 | 广东药科大学 | Chitosan composition and preparation method thereof |
| CN111374311A (en) * | 2018-12-29 | 2020-07-07 | 深圳碳云智能数字生命健康管理有限公司 | Nutrient composition, functional food and preparation method and application thereof |
| CN115554388A (en) * | 2022-11-03 | 2023-01-03 | 广州四季泰来生物技术有限公司 | Nutrition balance formula for improving female polycystic ovarian hormone level and production process |
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| CN101010090A (en) * | 2004-08-13 | 2007-08-01 | 小高勇 | Agent for preventing/ameliorating diabetes and functional food for preventing/ameliorating diabetes |
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| CN102077936A (en) * | 2010-09-20 | 2011-06-01 | 王强 | Special sea dietary food for diabetics |
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| CN1271608A (en) * | 1999-04-27 | 2000-11-01 | 陈嘉彦 | Health-care enzymatic chitosan food |
| CN101010090A (en) * | 2004-08-13 | 2007-08-01 | 小高勇 | Agent for preventing/ameliorating diabetes and functional food for preventing/ameliorating diabetes |
| CN101053409A (en) * | 2007-05-11 | 2007-10-17 | 汪昔奇 | Health care food containing natural astaxanthin |
| CN102077936A (en) * | 2010-09-20 | 2011-06-01 | 王强 | Special sea dietary food for diabetics |
| CN103110112A (en) * | 2012-12-03 | 2013-05-22 | 郭威 | Composite anti-oxidation nutritional food and processing method thereof |
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