CN103404875B - Complex ocean special-diet food eaten by patients with cardiovascular disease - Google Patents
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Abstract
The invention discloses complex ocean special-diet food eaten by patients with cardiovascular disease. The complex ocean special-diet food comprises oligochitosan, astaxanthin, beta-carotene, allicin, coenzyme Q10, vitamin C, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B3, vitamin B6, folic acid, vitamin B12 and macroelements calcium and magnesium as well as microelements iron, zinc, copper, manganese, selenium and chromium. The complex ocean special-diet food is a novel and complete nutritional food, can be used for comprehensively improving the nutrition conditions of the patients with cardiovascular disease and enhancing the organism immunity of the patients with cardiovascular disease, is beneficial to protecting the normal functions of the heart and coronary artery through the combined action of the oligochitosan and other natural active ingredients, improving the symptoms of cardiovascular diseases and reducing the occurrence rate of coronary heart disease complications, and is suitable for being taken by the patients with cardiovascular disease for long time.
Description
Technical field
The invention belongs to nutritious health caring food technology field, relate to a kind of for the special dietary seafood of the edible composite marine of cardiovascular patient.
Background technology
Angiocardiopathy, be called again circulation system disease, a series of diseases that relate to the circulatory system, the circulatory system refers to hemophoric Organ and tissue in human body, mainly comprise heart, blood vessel (artery, vein, capilary), can be subdivided into acutely and chronic, be all generally relevant with artery sclerosis.Wherein, coronary cardiopathy is a kind of modal angiocardiopathy, be called for short coronary heart disease, be a kind of myocardial ischemia-anoxemia (angina pectoris) being caused by coronary artery organic (atherosclerotic or dynamic property vasopasm) stenosis or occlusion or the heart disease of myocardial necrosis (miocardial infarction), also claim ischemic heart disease.Coronary heart disease human health with its high M & M serious threat, is " first killer " of harm humans life and health.Since the seventies in last century, along with rapid raising and the particularly quick change of dietary of life style of living standards of the people, the angiocardiopathies such as coronary heart disease rise year by year at the incidence of disease of China, and sicken age is tending towards rejuvenation.So the control form of the angiocardiopathy of China is very severe.
The pathogeny of coronary heart disease is still not clear so far, but the hazards of coronary heart disease are very clear and definite.At present medical circle generally believes, except heredity and age factor, most of hazards that affect incidence of coronary heart disease, comprise dyslipidemia, hypertension, diabetes, smoking, obesity, do not get enough athletic exercise and emotional factor etc., all can change.Have result of study to show, atherosclerotic is the Etiological of coronary heart disease, and LDL-C is to cause atherosclerotic root.
Coronary heart disease is one way of life mode disease, and dyslipidemia is relevant to diet.The diet of high heat, higher fatty acid, high cholesterol, high sugar, improves Incidence of CHD greatly.Therefore, meals are very important for controlling coronary heart disease and complication thereof.There are clear and definite regulation and perfect standard criterion in European and American developed countries to food of special nutrients, and have generally accepted for people.China has worked out " Chinese residents dietary guidelines " at present, and this guide was revised in 2007, taking " packing in advance food for special foods label general rule GB13432-2004 " as main regulatory documents.In this general rule, special diet is defined as: " for meeting the physiological requirements of some particular patient's, or the nutritional need of some Disease, by the food of the special processing of special formulation ".The science essence of particular patient's diet regulation and control is: control regular diet, supplement special diet, strengthening, for nutrition, reduces metabolism burden, promotes healthy.
At present, in China market, have for the edible food for special foods of patients with coronary heart disease, but great majority are all vitamin, mineral matter class and blood lipid-lowering medicine that some are simple, more or less all exist the irrational problem of composition, collocation and using dosage, so can not nurse one's health all sidedly the physiological function of cardiovascular patient, thereby be difficult to the effect that reaches desirable.In addition, in patent documentation, also can find to utilize the exploitation coronary heart disease health foods such as chitosan oligosaccharide, Co-Q10, marine polysaccharide, for example " patent No. CN201010290775.9 special sea dietary of patients with coronary heart disease ", but the formula content complexity of this patent, bring inconvenience to actual production, and its formula effect is not through zoopery checking.
Summary of the invention
For above-mentioned problems of the prior art, the present invention provides a kind of for the special dietary seafood of the edible composite marine of cardiovascular patient according to the deficiency of the physilogical characteristics of cardiovascular patient, nutritional need and conventional meals thereof, supplements for cardiovascular patient provides natural active matter and needed by human nutrient.Its chitosan oligosaccharide containing, astaxanthin, beta carotene, allicin, Co-Q10 and vitamin and mineral matter, can improve the nutrition condition of body patients with coronary heart disease, nurses one's health its physiological function comprehensively, plays the effect that improves immunity of organisms, improves symptom.
For achieving the above object, the present invention is achieved by the following technical solutions:
For the special dietary seafood of the edible composite marine of cardiovascular patient, its material composition content is as follows, in weight portion:
Further, the special dietary seafood of described composite marine also includes linseed oil 50-200 part.
Further, the special dietary seafood of described composite marine also includes extractive of flax seed 5-20 part.
Further, the special dietary seafood of described composite marine also includes sea cucumber polysaccharide 0.1-5 part, fucoidin sulfuric ester 20-300 part and L-carnitine-L-tartrate 8-30 part.
Further, the described chitosan oligosaccharide degree of polymerization is 2-15, and molecular weight is below 5000.
Further, the special dietary seafood of described composite marine is capsule, tablet, pulvis, granule, oral liquid or paste.
The present invention also provides the described preparation method for the edible special dietary seafood of composite marine of cardiovascular patient, it comprises the following steps: choose above-mentioned each material composition, add above-mentioned material according to the proportioning of described weight portion, after pulverizing and sieving, mix; Control temperature and prepare this product content below 60 DEG C, under lucifuge condition, routine operation makes pulvis, granule or capsule, and all operations all carries out in clean dried environment.
The described another kind of preparation method for the edible special dietary seafood of composite marine of cardiovascular patient, it comprises the following steps: choose above-mentioned each material composition, add above-mentioned material according to the proportioning of described weight portion, material is dropped into vacuum emulsification tank, stir, grind to obtain this product content; Gelatin, glycerine, purified water Hybrid Heating are stirred to gelatin and dissolve make softgel shell solution completely, vacuumize degassing, softgel shell solution is incubated to 55 DEG C-60 DEG C; Get foregoing thing and softgel shell solution, compressing, the dry soft capsule that makes.
Further, be under 0.08-0.09MPa, to vacuumize de-bubble to the greatest extent in vacuum.
Compared with prior art, advantage of the present invention and technique effect are:
The present invention is the special dietary seafood of a kind of novel, comprehensive composite marine, can improve the physiological function of cardiovascular patient comprehensively, removes free radical, improves immunity.
The present invention combines multiple natural active matter and nutrient, carry out reasonably combined, can give full play to the unique effect of each composition, can play again mutual promotion, complement each other, complementary effect, play more perfect than single component, more comprehensively with powerful effect, reached the requirement of product safety, effective, quality controllable health products.
Chitosan oligosaccharide used in the present invention, astaxanthin, beta carotene, allicin and Co-Q10 are natural active materials, have excretion of cholesterol, reducing blood lipid, anti-oxidant, the effect that strengthens immunity of organisms; The nutrient such as vitamin and mineral matter in invention is except being the nutrient that generally lacks of China resident simultaneously, also there is the effect of the physiological function that improves cardiovascular patient, their addition is with reference to Chinese residents Chinese DRIs every day, by the combination of active skull cap components and nutrient, the present invention is had to be incorporated multiple different efficacies composition in product, these compositions cooperatively interact, and synergy is comprehensively, balancedly patients with coronary heart disease extra-nutrition.Therefore the functional component of product and materials safety are high, and long-term edible having no side effect, is the desirable nutrient supplement food of cardiovascular patient.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described, and following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1
Be applicable to the special dietary seafood of the edible composite marine of cardiovascular patient, the content of its each material composition is:
The preparation method of the special dietary seafood of described composite marine comprises the following steps:
Get the degree of polymerization and be 2-15, molecular weight and be water-soluble chitosan oligosaccharide 500mg below 5000 and astaxanthin, beta carotene, allicin, Co-Q10, vitamin C, vitamin E, the vitamin D of above-mentioned formula ratio
3, Cobastab
1, Cobastab
2, Cobastab
3, Cobastab
6, folic acid, Cobastab
12, calcium gluconae, zinc lactate, ferrous lactate, magnesium gluconate, manganese citrate, copper gluconate, selenocysteine, nicotinate chromium mix, add after 100mg linseed oil and grind with grinder, afterwards material is dropped into vacuum emulsification tank, stir, grind to obtain this product content by grinder.Gelatin, glycerine, purified water ratio is in accordance with regulations mixed and heated to certain temperature (75 DEG C) to be stirred to gelatin and to dissolve completely, vacuumize degassing 30 minutes (vacuum 0.09MPa), get foregoing thing and softgel shell solution, compressing with soft capsule production equipment employing pressing, after being dried, obtain and be applicable to the special dietary seafood capsule of the edible composite marine of cardiovascular patient.
Introduce in detail the characteristic of the each material composition of the present invention below:
Chitosan oligosaccharide: be a kind of completely new product that shitosan is obtained through special biological enzyme technology processing, its good water solubility, biologically active is high, and heat is low, and is easily absorbed by the body.The function of chitosan oligosaccharide is very powerful, have improve blood pressure, hypoglycemic, suppress fat absorption, row cholesterol, anti-trioxypurine value, re-scheduling metal ion, inhibition tumor cell, adjusting pH value of human body, promote the function of wound healing, regulating intestinal canal and raising immunity.
Astaxanthin: being the one of carotenoid, is that the mankind find the antioxidant that nature is the strongest up to now, can ultraviolet radiation preventing; strengthen human body energy metabolism, suppress tumour, suppress diabetes and ephrosis; protection retina and central nervous system, improve immunity.There are some researches show, astaxanthin has increase HDL in vivo, alleviate the oxidation of density lipoprotein, alleviate the inflammatory reaction of macrophage, reduce the formation of AP, increase the stability of AP, reduce plaque rupture, improve effect of blood flow, thereby play the effect of prevention and cure of cardiovascular disease.
Beta carotene: being a kind of fat-soluble antioxidant, is the approach of current safest replenishing vitamins A.Research both at home and abroad shows, beta carotene not only can be hypotensive, hypoglycemic, reducing blood lipid, beauty treatment, defaecation and anti-ageing, also has that to improve immunologic function, PFT, the upper respiratory tract anti-infective and suppress the ability of tumor growth.Particularly, for cardiovascular health, beta carotene can be prevented and treated obstructive atherosclerotic formation, angiocardiopathy preventing.
Allicin: be a kind of extract taking garlic bulb as raw material, there is hypoglycemic, reducing blood lipid, anti-ageing, anti-oxidant, sterilization, anti-inflammatory and strengthen the effects such as body immunity.It can be by reducing hyperglycemia state that blood sugar alleviate diabetes to cardiovascular infringement, by reducing serum total cholesterol, suppress biologically active pdgf, reduce blood viscosity, hypotensive etc. be used for protecting cardiovascular health.
Co-Q10: be a kind of fat-soluble antioxidant, it is one of indispensable important element of human life, its can human activin cell and the nutrition of cellular energy, has the body immunity of raising, strengthens anti-oxidant, antitumor, anti-hypertension, delays senility and strengthen the functions such as human activity.The non-oxidizability of Co-Q10 makes it in atherosclerotic formation and development process, have certain inhibitory action, and it has remarkable result aspect allevating angina pectoris, the Co-Q10 of proper content is essential for suitable muscle function, contribute to, for cardiac muscle provides sufficient oxygen, can prevent sudden heart disease.
Linseed oil: be a kind of oils that is rich in alpha-linolenic acid of being squeezed by linseed, wherein the content of alpha-linolenic acid is 55%.Alpha-linolenic acid is essential fatty acid, in human body, can not synthesize, must be from external picked-up.It mainly comprises the following aspects to the protective effect of health: by increasing the excretion of cholesterol and suppressing endogenous cholesterol and synthesize to reduce serum cholesterol, regulate blood fat comprehensively; By reducing blood viscosity, increasing blood oxygen carrying content and prevent that thrombosis from preventing miocardial infarction; Promote insulin in blood, to remain stable, stabilizing blood sugar, reduces hypertension and normal arterial pressure is unaffected, the protection each organ of human body and nervous system simultaneously.
Extractive of flax seed (commercially available): main active is flax lignan class material.Flax lignan can alleviate various skin problems, consumption health superabundant fats, improves women's premenstrual syndrome, promotes health compressive resistance ability, improves arthritis, reduce cholesterol, atherosclerosis.Flax lignan not only has prevention effect to breast cancer, prostate cancer, menstrual period syndrome, osteoporosis, also to diabetes, stomach and intestine tumor, coronary heart disease, kidney trouble, and the effect that non-oxidizability is useful.
Sea cucumber polysaccharide: be mainly glycosaminoglycan extracted from sea cucumber or mucopolysaccharide, be present in wall of sea cucumber Stichopus japonicus corium connective tissue, body cavity, interior glandular tube and internal organ, there is enhanced machine body immunity function, anticoagulation, antithrombotic, reducing blood lipid, prevention of arterial is atherosis, antitumor, the physiological active functions such as delay senility.
Fucoidin sulfuric ester: claim again fucoidin, algal polysaccharide sulfate, it is peculiar marine active polysaccharide in brown algae sea-plant (sea-tangle etc.), belong to rare sulfuric ester ionic natural polysaccharide at occurring in nature, show to there is the immunity of raising, hypoglycemic, anticoagulation, reducing blood lipid, hypotensive, inhibition renal failure, the physiologically active such as antitumor through great many of experiments and clinical research.
L-carnitine-L-tartrate: l-cn is the necessary auxiliary substance of a kind of body fat oxidative metabolism.Because synthetic quantity in the low and body of content in food is less, l-cn lacks, and can produce hyperglycaemia, high fat of blood, angiocardiopathy, fatty liver, male sterility and weak symptom etc.As a kind of nutritional supplement of promotion oxidative cleavage of fatty acids of safe, effective, science, l-cn can reduce body fat, reduces body weight; Reduce serum total cholesterol and triglycerides, rising serum high-density LP; Strengthen the ability of cardiac muscle cell's oxidation of fat, the burden of heart while reducing high-intensity exercise; Improve cardiac arrhythmia and don't affect blood pressure; Improve immune function of human body, enhanced machine vitality of subject, fatigue-relieving, delays senility.L-carnitine-L-tartrate is a kind of stable form of l-cn, is difficult for the moisture absorption, easily preserves, and has and the identical effect of l-cn, and human body is had no side effect.
Vitamin C: be a kind of water soluble vitamin, for ensure human body metabolic normally carry out with the raising of immunologic function most important.It can not only treat scurvy and hypoferric anemia, and prevention gingival atrophy and hemorrhage promotes the normal synthetic of collagen, also can promote the excretion of cholesterol, prevent that cholesterol from depositing at Wall of Artery, even can make the atheromatous plaque of deposition dissolve, thus the generation of prevention and control coronary heart disease.In addition, ascorbic antioxidation can be resisted the injury of radical pair cell, improves body immunity.
Vitamin D: be a kind of liposoluble vitamin, be mainly used in composition and maintain the strong of bone, and immune system is had to humidification.The D that is deficient in vitamin is harmful to life and health, may cause as various diseases such as coronary heart disease.Therefore for patients with coronary heart disease, it is very necessary supplementing appropriate vitamin D.Vitamin D can reduce the tolerance to insulin, and insulin resistance is to cause one of cardiopathic principal element.
Vitamin E: being a kind of liposoluble vitamin, claiming again tocopherol, is one of topmost antioxidant, can stop the infringement of radical pair vascular wall.Tocopherol can promote sex hormone secretion, and man's sperm motility and quantity are increased; Make woman's female hormone Enrichment, improve fecundity, prevention of miscarriage.In addition, vitamin E is a kind of very important vasodilator and anticoagulant, prevention and treatment varication, and solidifying of anti-Hemostatic Oral Liquid, reduces the generation of speckle tissue; Improve blood circulation, protective tissue, reduction cholesterol, preventing hypertension; Improve lipid-metabolism, prevention of arterial is atherosis and coronary heart disease.
Cobastab
1: claim again thiamine or antineuritic vitamin or anti beriberi vitamin, it is not only human energy metabolism, and particularly glycometabolism is necessary, still maintains heart, and nerve and digestive system normal function are necessary.Its physiological function comprises promotion growth, helps digest; Improve mental status; Maintain the normal of nerve fiber, muscle, cardiomotility.
Cobastab
2: be again riboflavin, its physiological function comprises: participate in affecting biological oxidation and energetic supersession in human body, and relevant with the metabolism of carbohydrate, protein, nucleic acid and fat; The growth metabolism that participates in cell is the necessary nutrient of injected organism tissue metabolism and reparation; Relevant with absorption, storage and the mobilization of body iron; There is antioxidation biology activity etc.
Cobastab
3: claim nicotinic acid, it does not still maintain the vitamin of digestive system health yet, is the synthetic indispensable material of sex hormone, is cells activated by insulin agent yet, contributes to prevent and treat diabetes.Concerning life is full of the modern of pressure, nicotinic acid maintains effect of the healthy and brain function normal operation of nervous system, absolutely not can ignore.In addition, it can reduce cholesterol and triglyceride, stimulates circulation, and makes blood pressure drops, has stronger expansion peripheral vessels effect.
Cobastab
6: be body fat and glycometabolic essential material, contribute to atherosclerotic control.Have experiment to show, homovitamin B6 intake reduces the incidence of disease of myocardial infarction and lethal coronary heart disease, thereby angiocardiopathy is played to prevention effect.It is also very close with the relation of vitamin B2, and Vitamin B6 deficiency is often with vitamin B2 symptom.
Folic acid: be the one of B family vitamin, coordinate Cobastab
6and B
12, increasing of prevention homocysteine level, can improve function of vascular endothelium, angiocardiopathy preventing.
Cobastab
12: main Physiological Function is to participate in manufacturing erythrocyte, prevents pernicious anaemia; Safeguard nervous system health; Form with coenzyme exists, and can increase the utilization rate of folic acid, promotes the metabolism of carbohydrate, fat and protein; Fat metabolism acid, makes fat, carbohydrate, protein suitably be used by health.
Calcium: be a kind of inorganic salts that people's in-vivo content is maximum, it maintains the normal physiological state of all cells, as normally beating of heart; Calcium and magnesium, potassium, sodium plasma keep certain proportion, make nerve, muscle keep normal reaction; Calcium tool regulates the rhythm of the heart, reduces cardiovascular permeability, controls inflammation and oedema, maintains the effects such as acid-base balance.
Magnesium: be the indispensable element that maintains human life activity, there is the magical function that regulates N&M activity, strengthens endurance.In addition, magnesium is also " jinx " of hypertension, high cholesterol, hyperglycaemia, contributes to prevent and treat apoplexy, coronary heart disease and diabetes.
Iron: be the essential trace element of human body, to the menu of human body now in many aspects, iron participates in transport and the storage of oxygen to iron.These have the heart, liver, kidney in the cell mitochondrial of height physiological activity ability and biochemical function, and the iron of storage is many especially, and mitochondria is cell " energy factory ", and iron is participated in the release of energy directly.Iron can also promote to grow; Increase the resistance to disease; Regulate tissue respiration, prevent fatigue; Form ferroheme, the anaemia that prevention and treatment cause because of iron deficiency; Make skin recover good color.
Zinc: be the trace element of needed by human, but can not synthesize in vivo, can only rely on external food to provide.It is the constituent of the many important enzymes of human body, is also the necessary element of insulin synthesis; It synthesizes, safeguards erythrocytic integrality and all play an important role in hematopoiesis protein and nucleic acid, being the key element of enhancing development; It also can improve body immunity.
Copper: be the indispensable micronutrient of health, for blood, nervous centralis and immune system, growth and the function of the internal organ such as hair, skin and skeletal tissue and brain and liver, the heart have material impact.Calcareous and Lipid Plaque on copper degradable blood vessel wall, strengthen the function that connects cardiac myocyte fibr tissue, improve the connection of collagen, be conducive to the firm of arterial wall, make heart and blood vessel keep normal morphology and function, thereby reach the object of effective prevention and Cardiovarscular.
Manganese: it is relevant with human body different physiological roles, comprises and affects the normal growth of bone and growth, affects sugared metabolism, maintain must be indispensable in normal brain activity function.
Selenium: selenium and vitamin E are all antioxidants, and the two complements each other, the speed of its variation that can prevent from can slowing down because of aging that oxidation causes, the hardening of tissue, at least, has activated immune system, protects cardiovascular and antineoplastic effect; Can regulate glycometabolism, help diabetic to control blood sugar, be necessary trace mineral.Selenium also has detoxicating functions, because selenium and metal have good compatibility.
Chromium: be one of trace element in body, its content in vivo reduces gradually along with the increase at age.Though the requirement of chromium is few, can help insulin to promote that glucose enters intracellular efficiency, be important blood sugar regulator.It contributes to grow, and the cholesterol concentration in blood is also had to control action, and the formation of energy atherosclerosis, can able person cause heart disease when shortage.Therefore, take in right amount chromium, particularly for diabetic and cardiovascular patient, have important effect.
The emphasis difference of the various functional components in the present invention, various components have been combined together synergistic function, can obtain than the better effect of single component use aspect prevention and cure of cardiovascular disease and complication thereof.
Chitosan oligosaccharide is a kind of natural alkaline polysaccharide, one is with cationic natural polymer animal origin, it can control agent in acid-base balance, activation erythrocyte, purifies the blood, bidirectional modulation blood pressure, blood fat, alleviating vascular smooth muscle spasm, softening artery, recovers blood vessel elasticity, repair damaged vascular wall, thereby play the effect of prevention and cure of cardiovascular disease.Chitosan oligosaccharide is mainly realized the effect that regulates cholesterol, lowers blood fat by following approach: first, regulate and control conversion, the absorption and synthetic of cholesterol by affecting bile acid, aliphatic acid and inhibition cholesterol enzyme, the cholesterol in blood is down to and is normally unlikely to too low poised state; The second, by suppressing the lipolytic activity of pancreatic lipase, thereby reduce the hydrolysis of fat in enteron aisle, and then reduce fat absorption in vivo; The 3rd, chitosan oligosaccharide can form cation group after dissolving, and can be gathered in vivo around electronegative oil droplet, hinders fat absorption, and the fat of adsorption band anion also excretes, and reduces body fat and gathers.In addition, chitosan oligosaccharide can activate erythrocyte, changes intra-erythrocyte pressure reduction, removes it and assembles, and improves its oxygen therapy and exchange capacity; Positively charged chitosan oligosaccharide is combined and excretes with electronegative chlorion, can activate blood pressure vascular cell, improves microcirculation, reduces peripheral vascular resistance, reduce the deposition of lipid at vascular wall, thereby realize the effect that regulates blood pressure.Therefore, what chitosan oligosaccharide stressed to emphasize is directly to play a positive role for the adjusting of blood fat, blood pressure, and effect is more direct.
Astaxanthin is that the mankind find the antioxidant that nature is the strongest up to now, energy singlet-oxygen quenching and removing peroxylradicals; This effect outclass other carotenoid and vitamin E, can inhibitory mutagenesis, Cell differentiation inducing activity, anti-oxidant, there is the plurality of health care functions such as the free radical of removing, Cell protection, enhancing immunization, anti-inflammatory, angiocardiopathy preventing and cancer.Especially, astaxanthin astaxanthin has increase HDL in vivo, alleviates the oxidation of low-density lipoprotein, alleviate the inflammatory reaction of macrophage, reduce the formation of AP, increase the stability of AP, reduce plaque rupture, improve effect of blood flow.Therefore choosing chitosan oligosaccharide and astaxanthin is the main component of the special dietary seafood of this composite marine.
As the composite composition of chitosan oligosaccharide and astaxanthin, beta carotene, allicin, Co-Q10, linseed oil, extractive of flax seed, sea cucumber polysaccharide, fucoidin sulfuric ester, various vitamin and mineral matter have similar effect in a lot of functions: the effect of anti-oxidant, repair cell, regulate human body sugar and lipid metabolism, reduce blood fat, blood sugar, improve blood pressure, strengthen immunologic function, fatigue-relieving etc.In the present invention, these composite compositions and main component are superimposed and mutually promote, mutually supplement, and can play complementary " monarch " effect.Wherein, chitosan oligosaccharide and astaxanthin are " monarchs drug in a prescription ", in the special dietary seafood of this composite marine, prevention and cure of cardiovascular disease are played a major role, indispensable; Other composite compositions, or auxiliary " monarch drug in a prescription " stiffening effect, or work for double disease, or improve on the whole the physical condition of cardiovascular patient.Its effect is better than any single component or alone main component.
The organic or inorganic compound that the interpolation form of mineral matter of the present invention is this mineral matter.
In the present invention, the addition of vitamin and minerals is carried out with reference to " DRIs " of Chinese Soclety of Nutrition's promulgation in 2000, " nutrient prime replenisher is declared and evaluated regulation (trying) " middle " vitamin, mineral types and consumption " specifying that " food enrichment use sanitary standard " on July 1st, (GB14880-1994) He 2005, State Food and Drug Administration formally came into effect.
Prepared by the present invention can be made into the various ways such as capsule, tablet, pulvis, granule, oral liquid, paste for the special dietary seafood of the edible composite marine of cardiovascular patient.
Embodiment 2
Be applicable to the special dietary seafood of the edible composite marine of cardiovascular patient, the content of its each material composition is:
The preparation method of the special dietary seafood of described composite marine comprises the following steps:
Get purity and be 20%～60% flax lignan 15mg, sea cucumber polysaccharide 5mg that molecular weight is 4-5 ten thousand and chitosan oligosaccharide, astaxanthin, beta carotene, allicin, Co-Q10, fucoidin sulfuric ester, L-carnitine-L-tartrate, vitamin C, vitamin E, neo dohyfral D3, the Cobastab of above-mentioned formula ratio
1, Cobastab
2, Cobastab
3, Cobastab
6, folic acid, Cobastab
12, calcium gluconae, zinc lactate, ferrous lactate, magnesium gluconate, manganese citrate, copper gluconate, selenocysteine, nicotinate chromium mix; Add first forward in mixer to be dry mixed stirring the above-mentioned raw material mixing, 10% dextrin starch slurry can be divided to count several times and in mixer, carry out wet mixing and close, continuous stirring, makes softwood; Getting above-mentioned softwood sends in oscillating granulator and granulates with 16 eye mesh screens; The particle making is put into baking oven dry, moisture below 3% time, can stop being dried, and gives free rein to dry in the air cool; Then cross 14 eye mesh screens and carry out whole grain, make the single-size shape this product that meets the requirements big or small.
Embodiment 3, implementation result experiment
Implement mouse experiment with the special dietary seafood of the edible composite marine of cardiovascular patient that is applicable in embodiment 2.
Adopt high lipid food to feed male ApoE in 4 week age
-/-mouse, sets up atherosclerotic (AS) model, 4 week age male ApoE
-/-100 of mouse, are divided into 5 groups at random: (1) model group; (2) rosuvastain calcium (5mg/kg/d) group; (3) chitosan oligosaccharide absorption group (20mg/kg/d); (4) this product standard absorption group (25mg/kg/d); (5) the collaborative absorption group of this product (25mg/kg/d) and rosuvastain calcium (5mg/kg/d), implementation method is gavage after distilled water diluting.Meanwhile get 4 week age 20 of male C57BL/6J wild-type mices as Normal group.High lipid food was fed after 12 weeks, put to death mouse, collected serum, used enzymic colorimetric to measure TC, TG in serum, used direct measuring method to measure Serum HDL-C, LDL-C.Take out mouse aorta, with FFPE, row aorta root serial section, after application haematoxylin-Yi red colouring (HE dyeing), the histological characteristic of observation mouse atherosclerotic (AS) plate and plaque area (PA), vessel lumen area (LA), the plaque area of calculation correction is than (PA/LA).
The each group of table 1 Comparison of experiment results
Table 1 experimental result shows:
1, the ApoE that high lipid food is fed
-/-mouse is compared its aortic root of wild type and has formed obvious atherosclerotic, and patch volume increases.
2, only adding experimental mice serum TC, the LDL-C of this product to compare its concentration of model group group all has decline in various degree, and plaque area also has remarkable reduction difference to have conspicuousness (P<0.05) than (PA/LA); Take in separately that chitosan oligosaccharide group relative model group also has remarkable reduction (P<0.05) but degree not as good as this product absorption group.
3, rosuvastain calcium experimental mice AP Area Ratio is less than above two groups, and difference has conspicuousness (P<0.05); Rosuvastain calcium and this product experimental mice serum TC, LDL-C further reduce and AP Area Ratio (PA/LA) further dwindles, and difference has conspicuousness (P<0.05).
These results suggest that this product is compared takes merely chitosan oligosaccharide and can more effectively reduce serum lipid concentrations in mice serum, slows down the formation of atherosclerotic and tube wall patch, and takes together with cardiovascular drugs and can play more significant effect.
To sum up; the present invention is according to patient's nutritional need; the edible special dietary seafood of composite marine of the confession cardiovascular patient of preparation taking chitosan oligosaccharide as primary raw material; not only be conducive to the excretion of cholesterol and reduce blood cholesterol levels; protection cardiovascular system; thereby improve the symptom of angiocardiopathy and reduce the incidence of Coronary Artery Disease Complicated disease; and multiple natural active matter and multivitamin and the mineral matters such as astaxanthin, beta carotene, allicin, Co-Q10 are added; the nutrition condition that can comprehensively improve cardiovascular patient, obviously strengthens resistance against diseases.
Above embodiment is only in order to technical scheme of the present invention to be described, but not is limited; Although the present invention is had been described in detail with reference to previous embodiment, for the person of ordinary skill of the art, the technical scheme that still can record previous embodiment is modified, or part technical characterictic is wherein equal to replacement; And these amendments or replacement do not make the essence of appropriate technical solution depart from the spirit and scope of the present invention's technical scheme required for protection.
Claims (3)
1. for the special dietary seafood of the edible composite marine of cardiovascular patient, it is characterized in that its material composition content is as follows, in weight portion:
The wherein said chitosan oligosaccharide degree of polymerization is 2-15, and molecular weight is below 5000.
2. according to claim 1 for the special dietary seafood of the edible composite marine of cardiovascular patient, it is characterized in that: the special dietary seafood of described composite marine is capsule, tablet, pulvis, granule, oral liquid or paste.
3. the preparation method for the edible special dietary seafood of composite marine of cardiovascular patient according to claim 1, it is characterized in that it comprises the following steps: choose above-mentioned each material composition, proportioning according to described weight portion adds material, material is dropped into vacuum emulsification tank, stir, grind to obtain content; Gelatin, glycerine, purified water Hybrid Heating being stirred to gelatin and dissolving make softgel shell solution completely, is vacuumize degassing under 0.08-0.09MPa in vacuum, and softgel shell solution is incubated to 55 DEG C-60 DEG C; Get foregoing thing and softgel shell solution, compressing, the dry soft capsule that makes.
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| CN110393293A (en) * | 2019-07-05 | 2019-11-01 | 上海复旦奥医医学科技有限公司 | A kind of coronary heart disease tailored version clinical nutrition formula and preparation method thereof |
| CN115702906A (en) * | 2021-08-09 | 2023-02-17 | 深圳奥萨制药有限公司 | Composition for preventing and improving cardiovascular diseases |
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| CN101474201A (en) * | 2008-12-15 | 2009-07-08 | 北京利千秋科技发展有限公司 | Pharmaceutical composition for reducing blood fat |
| CN103110112A (en) * | 2012-12-03 | 2013-05-22 | 郭威 | Composite anti-oxidation nutritional food and processing method thereof |
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