CN106858595A

CN106858595A - One kind burn tailored version clinical nutrition formula and preparation method thereof

Info

Publication number: CN106858595A
Application number: CN201710197736.6A
Authority: CN
Inventors: 尤俊; 季敬东
Original assignee: Shanghai Olympic Medical Biotechnology Co Ltd
Current assignee: Shanghai Olympic Medical Biotechnology Co Ltd
Priority date: 2017-03-29
Filing date: 2017-03-29
Publication date: 2017-06-20

Abstract

The present invention relates to one kind burn tailored version clinical nutrition formula, including protein and amino acid, nucleotides, fat, carbohydrate, dietary fiber, macroelement, trace element, vitamin, meals elite, integration of drinking and medicinal herbs composition, natural plants compound and new resource food；Wherein amino acid includes L glutamine, L arginine, taurine；Integration of drinking and medicinal herbs composition includes peppermint, Poria cocos, pawpaw, dandelion, spina date seed, honeysuckle；Its preparation method is：Each component is made powder in advance, is then made corresponding formulation, and wherein integration of drinking and medicinal herbs composition carries out water extraction concentration, spray drying and is made powder, and vitamin and fat are processed by microencapsulation and is made powder；Or by wet processing each component is carried out emulsifying homogeneous, spray drying be made powder.Compared with prior art, nutrient formulation of the present invention can correct the abnormal pathologic of fire victim, physiological change, strengthen the immunity and anti-infection ability of patient, and the normal function of body is maintained comprehensively.

Description

One kind burn tailored version clinical nutrition formula and preparation method thereof

Technical field

The present invention relates to enteral nutrition preparation field, and in particular to one kind burn tailored version clinical nutrition formula and its preparation Method.

Background technology

Burn is the infringement that heating power causes skin or other tissues, refers mainly to skin or mucous membrane, and severe patient can also injure skin Lower or sub-mucosal tissues, such as muscle, bone, joint even internal organ.Area is big, the serious burn more than depth, can cause the whole body one to be The physiologic derangement of row, such as nerve, endocrine, breathing, excretory system；The function of each main organs and metabolism and immune response are all Change, burn is a kind of wound of systemic damage, in CC, it may occur however that infection, toxaemia septicemia and Other severe complications.

Burnt degree patient due to tissue serious damage, and by violent stress reaction and the shadow of various neuroendocrine factors Ring, body all occurs a series of changes in terms of sugar, protein, fat, vitamin, metabolism of trace elements.On the one hand tissue divides Solution aggravation, protein is largely lost, and energy ezpenditure increases, and metabolic rate is raised；When another aspect body recovery and wound repair Need a large number of nutrients.Correct metabolic nutrition support and conditioning, advantageously reduce organism metabolism consumption, safeguard organ function, Enhancing immunologic mechanism, prevention and infection control, wound healing.

But the treatment means currently for fire victim are generally wound external application painting medicament, oral traditional Chinese medicine preparation, parenteral battalion Support agent (as being injected intravenously).Wound external application applies medicament and oral traditional Chinese medicine preparation is only used for the anti-inflammatory analgetic of wound, eliminates infection, promotees Enter wound healing, it can not provide the comprehensively nutritional need such as protein, fat for fire victim；Parenteral nutrition agent is (such as quiet Arteries and veins is injected) although certain nutritional support can be provided for fire victim, transfusion capacity and nutriment input quantity are difficult to control to, And transfusion time is more long.

With the development of food of special nutrients, according to the physilogical characteristics and nutritional need of fire victim, for fire victim The special formulation food of exploitation is also increasing, and for example Chinese patent CN105901703A discloses a kind of for fire victim's Marine organism type enteral nutrition preparation, it contains following active ingredient：Protein, fat, carbohydrate, B B-complex, Composite mineral matter, Taurine, choline etc., it can provide balanced nutritious for patient, but not refer to the anti-infective energy of fire victim Power, and its active ingredient and be not added with integration of drinking and medicinal herbs composition and natural plants compound, its nutritional need to fire victim and Recovery time exists certain not enough.

Therefore, developing the various nutrients needed for can providing fire victim, and can improve the immunity, anti-infective burnt Ability, and then the enteral nutritional prescription product of therapeutic effect is improved, with important value and wide market.

The content of the invention

It is an object of the invention to overcome defect of the prior art, there is provided one kind burn tailored version clinical nutrition formula and Its preparation method, burn tailored version clinical nutrition formula comprehensive nutritional support for fire victim provides prepared by the present invention, its Suitable energy and various critical nutrients needed for containing fire victim, there is provided completely must micro-nutrient composition；Pass through Integration of drinking and medicinal herbs composition of the addition containing various functional active components, regulation body function improves resistance, improves anti-infection ability, Coordinating intestines and stomach, promotes the absorption of all kinds of nutriments simultaneously, and each composition complements each other in nutrient formulation of the present invention, can have The nutrition intake that effect improves fire victim is not enough, and conditioning engine body function, is conducive to the early recovery of fire victim.

To achieve the above object, the present invention is adopted the following technical scheme that：

On the one hand, the present invention provides a kind of burn tailored version clinical nutrition formula, including following component：Protein and amino Acid, nucleotides, fat, carbohydrate, dietary fiber, macroelement, trace element, vitamin, meals elite, integration of drinking and medicinal herbs Composition, natural plants compound and new resource food；Wherein, the amino acid includes Glu, L-arginine, ox sulphur Acid；Wherein, the integration of drinking and medicinal herbs composition includes peppermint, Poria cocos, pawpaw, dandelion, spina date seed, honeysuckle.

In order to further optimize above-mentioned technical proposal, the technical measures that the present invention is taken also include：

Preferably, the ratio of n-6 aliphatic acid and n-3 aliphatic acid is 4 in the fat:1~2.

Preferably, the burn tailored version clinical nutrition formula, also including food thickening agent and food additives, the food Product thickener be guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum at least One kind, the food additives are at least one in Aspartame, flavoring essence spices, brown sugar.

Preferably, the vitamin is water soluble vitamin and liposoluble vitamin, the weight of the liposoluble vitamin Account for the 10%~40% of vitamin gross weight.

Preferably, the dietary fiber is water-soluble dietary fiber.

Preferably, the parts by weight of the component are：Protein and 20~40 parts of amino acid, 0~1 part of nucleotides, fat 10~20 parts, 30~60 parts of carbohydrate, 2~8 parts of dietary fiber, 0.6~1.2 part of macroelement, trace element 0.05- 0.2 part, 0.1~0.3 part of vitamin, 0.2~0.5 part of meals elite, 0.2~3 part of integration of drinking and medicinal herbs composition, natural plants compound 0.1-1 parts and new resource food 0.01-0.2 parts.

Preferably, the parts by weight of each component are as follows in the integration of drinking and medicinal herbs composition：0~1 part of peppermint, 0~1 part of Poria cocos, 0~1 part of pawpaw, 0~1 part of dandelion, 0~1 part of spina date seed, 0~1 part of honeysuckle.

Preferably, the protein is selected from PURE WHEY, soybean protein isolate, whole milk powder, dried whole-egg, newborn iron egg In vain, at least one in bovine colostrum, protein peptides；Wherein, the protein peptides are selected from soybean oligopeptide, wheat protein peptide, silkworm chrysalis At least one in protein peptides, ocean fish oligopeptide powder, laughable peptide, amino peptide, ovalbumin peptide

Preferably, the amino acid is selected from 1B-Pidolidone, Pidolidone, L-arginine, L-Trp, L- At least one in glutamine, taurine, Valine, ILE, L-Leu.

Preferably, the nucleotides is 5'- monophosphate cytidines.

Preferably, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structures At least one in fat, DHA, EPA, ARA, phosphatide, more specifically it is described fat include safflower seed oil, walnut oil, peanut oil, Soybean oil, Ah's glycerine, olive oil, tea oil, oil and fat of sacha inchi, coconut oil, perilla herb oil, deep sea fish oil, cupu oil, palm oil, butter, Cream, lard, medium chain triglyceride, lecithin, single diglycerine fatty acid ester.

Preferably, the carbohydrate is including in fructose, rock sugar, lactose, maltodextrin, tapioca, resistant starch At least two.

Preferably, the dietary fiber comprising inulin, konjaku flour, galactooligosaccharide, FOS, oligoisomaltose, At least one in soybean polyoses, cyclodextrin, resistant dextrin, fibre and soya.

Preferably, the macroelement is selected from calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, K-IAO, citric acid At least one in sodium, magnesium gluconate, magnesium sulfate.

Preferably, the trace element is selected from ferrous gluconate, KI, zinc gluconate, sodium selenite, glucose At least one in sour copper, chromium sulfate, manganese gluconate and sodium molybdate.

Preferably, the liposoluble vitamin is selected from vitamin A, beta carotene, vitamin D₃, vitamin E, vitamin K₁ In at least one.

Preferably, the water soluble vitamin is selected from vitamin B₁, vitamin B₂, vitamin B₆, vitamin B₁₂, vitamin At least one in C, pantothenic acid, folic acid, nicotinic acid, choline, inositol, biotin.

Preferably, the meals elite is selected from cereal, beans, potato class, greengrocery, Homonemeae, nut-seed class, fishes and shrimps At least one in class, poultry meat, fruits；Wherein described cereal it is main by rice meal, millet powder, black rice flour, coixlacrymajobi powder, One kind in corn flour, wheat germ powder, oatmeal, buckwheat or at least two compositions, the beans it is main by peameal, it is green One kind or at least two compositions in bean powder, black bean powder, red bean powder, soy meal, the potato class are mainly made up of common yam rhizome powder, described Vegetable powder is main by carrot meal, white radish powder, pumpkin powder, spinach powder, tomato meal, broccoli powder, balsam pear powder, cucumber powder Plant or several compositions, the Homonemeae is main by one or more in mushroom powder and white fungus powder, and the nut-seed class is main It is lotus nut starch, the fish and shrimp are mainly and are made up of one or more in salmon powder and cod meal, the poultry meat master If being made up of one or more in chicken meal, powdered beef, the fruits are main by red date powder, longan powder, apple powder, cherry One or more compositions in peach powder, oranges and tangerines powder, pyrus nivalis powder；The preferred red bean powder of meals elite.

Preferably, the natural plants compound is selected from l-cn, Glucosamine, FOS, lutein, tomato At least one in red pigment, resveratrol, allicin；The natural plants compound is preferably l-cn.

Preferably, the new resource food is selected from first milk basic protein, GABA, chitosan oligosaccharide, eucommia Bark male flower, freshwater mussel Meat polysaccharide, phytosterol, bamboo-leaves flavones, CPP, avenabeta glucosan, yeast beta-dextran, leaf of Moringa, oligomeric wood At least one in sugar；The new resource food is preferably phytosterol.

On the other hand, it is the present invention relates to a kind of preparation method of above-mentioned burn tailored version clinical nutrition formula including as follows Step：

It is step one, the protein and amino acid of predetermined weight number, nucleotides, fat, carbohydrate, meals are fine Dimension, macroelement, trace element, vitamin, integration of drinking and medicinal herbs composition, natural plants compound and new resource food are prepared respectively Into the powder that particle diameter is 150~250 μm；

Step 2, the powder for preparing the step one are poured into cone-type mixer and are well mixed successively；

Step 3, using the step one be well mixed powder be prepared into nutrient powder, nutrition emulsion, capsule, tablet, At least one in pill or oral liquid；

Wherein, the raw material of the integration of drinking and medicinal herbs composition is crushed, water extraction concentrates, and concentrate is carried out into spray drying system Into integration of drinking and medicinal herbs component powders；

Wherein, the vitamin and fat are processed by microencapsulation be prepared into vitamin powder and fat powder respectively.

Preferably, the preparation process of the integration of drinking and medicinal herbs component powders is as follows：Using pulverizer to predetermined weight number Raw material is crushed, and the raw material of crushing is placed in container, and it is 3~8 times of raw material weight of water to add weight, carries out immersion 3 ~4 hours, 30~60min of decoction is then carried out to soak, filtering removal raw material leaves and takes decoction liquor, decoction liquor is sprayed Mist drying prepares integration of drinking and medicinal herbs component powders.

Preferably, what the microencapsulation of the vitamin was processed comprises the following steps that：1) using liposoluble vitamin as core Material, from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, big Beans separate albumen, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, fibre and soya, lactose, rock sugar One or more in powder, emulsifying agent, stabilizer as wall material, high-pressure homogeneous emulsification, spraying is instantaneous to be dried, and screening prepares liposoluble Property vitamin powder；2) using water soluble vitamin as core, from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, inulin, whey egg Mixed as wall material for one or more in white powder, oligoisomaltose, fibre and soya, lactose, candy sugar powder, emulsifying agent, stabilizer Close uniform, spraying is instantaneous to be dried, and screening prepares water soluble vitamin powder.

Preferably, the specific implementation step of the micro-capsule embedding techniques of the fat is as follows：By fat, emulsifying agent, wall material with Water mixed dissolution prepares emulsion；After by the stirring mixing of above-mentioned emulsion, emulsifying homogeneous treatment is carried out, then carry out spraying dry Dry, screening prepares powdered oil, and powdered oil compares with conventional grease, and its dispersiveness, water solubility, emulsibility, inoxidizability are all Improve a lot；Wherein, the emulsifying agent be selected from fatty acid glyceride (glyceride), methyl glycol fatty acid ester (propylene glycol ester), One or more in sorbitan aliphatic ester (sorbitan acid), sucrose fatty ester (sucrose ester), lecithin；The wall Material is selected from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, big Beans separate albumen, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, fibre and soya, lactose, rock sugar One or more in powder, emulsifying agent, stabilizer.

The present invention also provides a kind of preparation method of above-mentioned burn tailored version clinical nutrition formula, and it is wet processing, bag Include following steps：

Step 1) prepare the protein containing predetermined weight number and amino acid, nucleotides, fat, carbohydrate, meals The original of food fiber, macroelement, trace element, vitamin, integration of drinking and medicinal herbs composition, natural plants compound and new resource food Material, according to the physical behavior of raw material, adds successively according to sequencing, is stirred while addition, and raw material is obtained Mixed emulsion；

Step 2) by step 1) temperature of mixed emulsion that obtains is maintained at 40-50 DEG C, adjustment homogenization pressure makes it all the time Be maintained between 10-18Mpa, emulsifying homogeneous carried out to mixed emulsion, then by emulsion place evaporator in, with default skill Art parameter is concentrated, and sterilization is carried out at 85-88 DEG C, obtains concentrate；

Step 3) by step 2) concentrate that obtains is spray-dried, and crosses 60~80 mesh sieves, is prepared into powder；Using upper State at least one during powder is prepared into nutrient powder, nutrition emulsion, capsule, tablet, pill or oral liquid.

Using having strengthen immunity, improving anti-infective, function of spleen and stomach regulating integration of drinking and medicinal herbs composition, it includes thin the present invention Lotus, Poria cocos, pawpaw, dandelion, spina date seed, honeysuckle.

Active ingredient peppermint oil, menthol in peppermint can suppress the life of the fungies such as sclerotinite, rhizopus stolonifer, mucor Long and breeding；Peppermint oil shows stronger inhibitory action to two kinds of hypotypes (HSV21 and HSV22) of herpes simplex virus；Together When peppermint oil have obvious choleretic effect, and can slightly increase the discharge rate of bile acid in bile；And peppermint oil Carrageenan Causing rat paw edema has certain inhibitory action, has functions that anti-inflammatory analgesic.

Poria cocos can strengthen body's immunity, and it has the effect of anti-atrophy of thymus gland, the increase of anti-spleen and tumor suppression growth；Fu Siberian cocklebur polysaccharide has obvious antitumor action；There are diuresis, the discharge of the electrolyte such as potassium, sodium, chlorine in urinating can be increased；Have it is calm and The effects such as protection liver, generation, the hypoglycemic, anti-radiation for suppressing ulcer；Poria cocos also has antibacterial, anti-inflammatory, antivirus action, its There is inhibitory action to staphylococcus aureus, staphylococcus albus, A type/beta streptococcus etc..

Contain multiple beneficial composition, including pawpaw polysaccharide, papain, oleanolic acid, phytosterin compound in pawpaw Deng；Pawpaw polysaccharide has anticoagulation, suppression infection, imperial radiation, antitumor, anti-inflammatory, antiviral, the anti-ageing effect of waiting for a long time, and is preferable Immunopotentiator；Papain can decomposing protein, have auxiliary treatment enterogastritis, indigestion, pawpaw contains various water Soluble vitamin, is such as rich in vitamin C, helps to repair body tissue, eliminates the noxious material of infringement body cell, strengthens people Body resistance against diseases；Oleanolic acid exists with monomer or saponin form, internal with anti-inflammatory, strengthen immunity, transaminase lowering, correction Paraprotein is metabolized, prevents cirrhosis；Phytosterin compound, has stronger antiinflammatory action to human body, can promote wound healing, Make hypertrophy, enhancing capillary circulation.

There is dandelion resisting pathogenic microbes to act on, and it has to staphylococcus aureus resistance bacterial strain, hemolytic streptococcus Stronger bactericidal action, to Diplococcus pneumopniae, meningococcus, corynebacterium diphtheriae, Pseudomonas aeruginosa, proteus, shigella dysenteriae, wound Cold bacillus etc. and micrococcus catarrhalis also have certain bactericidal action；With liver protection, choleretic effect, the paddy third that it causes to carbon tetrachloride Transaminase is raised obvious inhibiting effect, can significantly alleviate the Histological change that carbon tetrachloride hepatic injury causes；With anti-stomach Ulcer function, it has notable protective effect to mucosal lesion；With the effect for improving immunologic function, human peripheral pouring can be improved Bar cell blasts conversion ratio, Taraxacum Polysaccharides can significantly increase ehrlich carcinoma and MM46 tumor-cell antigen induced mice foots pad are slow Hair style hypersensitivity intensity.

Active ingredient soaping agents and flavone compound in spina date seed have significant calm and syngignoscism, spina date seed Also there is obvious anticonvulsant action, can substantially suppress excitation of the Benzylpenicillin sodium salt to neuronal cell, reduce glutamic acid water Flat rising, and have antiepileptic action；Spina date seed glycoside also shows have significant protective effect to cardiovascular system, with anti- Scheming ischemic effect；Spina date seed aqueous extract has obvious antiinflammatory action, can suppress mouse peritoneal, skin of back and auricle hair Thin vasopermeability, has inhibitory action to the granuloma that the swelling of rat hindleg egg white and the rat oxter implantation scraps of paper are produced.

Honeysuckle is to the double balls of various pathogens such as staphylococcus aureus, hemolytic streptococcus, pneumococcus, meningitis Bacterium, Pseudomonas aeruginosa etc. have antibacterial and bactericidal action, and infected by influenza, orphan virus, herpesviral, Leptospira have suppression Effect；Honeysuckle has clearing heat and detoxicating, dispelling wind and heat from the body effect, can treat summer fever, rush down dysentery, influenza, sore furuncle poison, acute and chronic The diseases such as tonsillitis, periodontitis.

The present invention is also used includes the amino acid and nucleotides of Glu, L-arginine, taurine.Glutamine Small intestine epithelium can be repaired, intestinal barrier function is maintained, enteric bacteria and toxin displacement is prevented and reduced enterogenic infection.Arginine Arginic nutritional support can be strengthened can effectively facilitate cellular immune function, immunity be effectively improved, to inhibiting tumor cell and prevention Virus infection.Nucleotides can correct the Cellular Immune Disturbances of burn patient, reduce wound sepsis's incidence, mitigate burn Infection, improves fire victim's immunologic function, and fire victim's immunological function repression is corrected from cellular level, it is rebuild immune work( Energy.

The ratio that n-6 aliphatic acid and n-3 aliphatic acid in fat are used in the present invention is 4:1~2, n-3 aliphatic acid can adjust The inflammatory reaction of immunity, improves sepsis or MOF as much as possible.

New resource food phytosterol is used in the present invention, it has stronger antiinflammatory action to human body, with can press down Human body processed is to the absorption of cholesterol, the katabolism that promotes cholesterol, the effect such as biochemical synthesis that suppresses cholesterol；It can promote Wound healing, makes the functions such as hypertrophy, enhancing capillary circulation.

Compared with prior art, the present invention has following excellent effect：

(1) with Traditional Chinese medical theory be combined modern nutriology achievement in research by the present invention, by the organic of various components Combination, various functions are merged, and by the synergy between active ingredient, humidification effect.Match somebody with somebody by the present invention The food that side makes can not only supplement nutrition needed for fire victim, moreover it is possible to promote body condition improvement using medicinal herb componentses.

(2) present invention addition has integration of drinking and medicinal herbs composition that is anti-infective, strengthening immune conditioning digestion effect, adds raising Immunity, the amino acid and nucleotides that reduce wound sepsis's incidence, mitigate infection of burn, addition can adjust immunity The n-3 aliphatic acid of inflammatory reaction, phytosterol of the addition with anti-inflammatory, promotion wound healing, its each component complements each other, treats Effect is definite, can correct abnormal pathologic, the physiological change of fire victim, maintain body cell and tissue, the normal configuration of organ and Function, enhancing patient is immune, therapeutic effect is improved, with early recovery.

(3) present invention with the addition of dietary fiber, its nutritional status that can improve Cavity in Critical Patients, and the negative nitrogen for correcting body is put down Weighing apparatus；Improve the immunologic function of Cavity in Critical Patients, reduce the generation of complication；The blood sugar of Cavity in Critical Patients is effectively reduced, is reduced high The harm of blood sugar, mitigates the stress reaction of patient；Promote gastrointestinal motility, improve gastrointestinal function, mitigate excessive inflammatory reaction, Prevent the generation of enterogenic infection.

(4) present invention prepares vitamin using micro-capsule embedding techniques, and vitamin is embedded in wall material, can prevent dimension from giving birth to Element is destroyed by macroelement, trace element, extends the holding time of vitamin；The present invention is prepared using micro-capsule embedding techniques Powdered oil so that powdered oil has preferable mobility, it is easy to be well mixed with other powdered components；And use micro-capsule bag After burying technology, grease is embedded in wall material, so as to avoid the contact with air to strengthen inoxidizability, so as to guarantor can be played The maximum effect of strong type grease.

(5) raw material of burn tailored version clinical nutrition formula of the present invention in preparation process it is previously prepared into 150~250 μm of powder, this is caused when finished product is prepared, and each nutrition composition can be well mixed, it is ensured that each in unit volume The content of nutrition composition is identical, while when liquid type preparation is prepared, each nutrition composition can be fully dispersed and be completely dissolved to molten In agent, prevent solids of sedimentation occur in liquid, effect of finished product product has been effectively ensured.

Specific embodiment

The present invention provides a kind of for burn tailored version clinical nutrition formula tailored version clinical nutrition formula, including following weight Measure the component of number：20~40 parts of protein and amino acid, 0~1 part of nucleotides, 10~20 parts of fat, carbohydrate 30~ 60 parts, 2~8 parts of dietary fiber, 0.6~1.2 part of macroelement, 0.05-0.2 parts of trace element, 0.1~0.3 part of vitamin, meals 0.2~0.5 part of elite of food, 0.2~3 part of integration of drinking and medicinal herbs composition, 0.1-1 parts of natural plants compound and new resource food 0.01-0.2 parts；Wherein, the vitamin is water soluble vitamin and liposoluble vitamin, the weight of the liposoluble vitamin Account for the 10%~40% of vitamin gross weight；Wherein, the dietary fiber is water-soluble dietary fiber, n-6 fat in the fat Fat acid is 4 with the ratio of n-3 aliphatic acid:1~2.

With reference to embodiment, specific embodiment of the invention is further described.Following examples are only used for more Plus the technical solution of the utility model is clearly demonstrated, and can not be limited the scope of the invention with this.

Embodiment 1

Burn tailored version clinical nutrition formula of the present invention includes PURE WHEY 10.4g, soybean protein isolate 5.2g, whole milk powder 12g, dried whole-egg 0.33g, colostrum 0.16g, taurine 0.12g, ocean fish oligopeptide 0.1g；The mono- phosphorus of 5'- Sour cytidine 0.1g；Olive oil 2.77g, soybean oil 4.48g, coconut oil 2.77g, perilla herb oil 0.64g, medium chain triglyceride 0.21g； Maltodextrin 35g, rock sugar 6.2g, tapioca 7.49g；Dietary fiber 3.5g；Calcium 0.44g, phosphorus 0.23g, potassium in macroelement 0.08g, sodium 0.14g, magnesium 0.19g；Iron 0.015g, iodine 0.00014g, zinc 0.13g in trace element；Vitamin A 0.0005g, Beta carotene 0.000057g, vitamin D₃0.000002g, vitamin E 0.01g；Vitamin B₁0.001g, vitamin B₂ 0.001g, vitamin B₆0.001g, vitamin B₁₂0.000003g, vitamin C 0.188g, pantothenic acid 0.005g, folic acid 0.000165g, nicotinic acid 0.0161g；Red bean powder 0.33g；Peppermint 0.05g, Poria cocos 0.05g, pawpaw 0.05g, dandelion 0.05g, Spina date seed 0.05g, honeysuckle 0.05g；L-cn 0.63g in natural plants compound,；Phytosterol in new resource food 0.05g；Wherein, the dietary fiber is all water-soluble dietary fiber；The weight of the liposoluble vitamin accounts for vitamin gross weight The 10%~40% of amount；The ratio of n-6 aliphatic acid and n-3 aliphatic acid is 4 in the fat:1.

Embodiment 2

Burn tailored version clinical nutrition formula of the present invention includes PURE WHEY 10.4g, soybean protein isolate 5.2g, whole milk powder 12g, dried whole-egg 0.33g, colostrum 0.16g, taurine 0.12g, ocean fish oligopeptide 0.1g；Olive oil 2.77g, soybean oil 4.48g, coconut oil 2.77g, perilla herb oil 0.64g, medium chain triglyceride 0.21g；Maltodextrin 35g, rock sugar 6.2g, tapioca 7.49g；Dietary fiber 3.5g；Calcium 0.44g, phosphorus 0.23g, potassium 0.08g, sodium 0.14g, magnesium in macroelement 0.19g；Iron 0.015g, iodine 0.00014g, zinc 0.13g in trace element；Vitamin A 0.0005g, beta carotene 0.000057g, vitamin D₃0.000002g, vitamin E 0.01g；Vitamin B₁0.001g, vitamin B₂0.001g, dimension Raw element B₆0.001g, vitamin B₁₂0.000003g, vitamin C 0.188g, pantothenic acid 0.005g, folic acid 0.000165g, nicotinic acid 0.0161g；Red bean powder 0.33g；Peppermint 0.17g, Poria cocos 0.17g, pawpaw 0.17g, dandelion 0.17g, spina date seed 0.17g, gold Honeysuckle flower 0.17g；L-cn 0.63g in natural plants compound,；Phytosterol 0.1g in new resource food；Wherein, the meals Food fiber is all water-soluble dietary fiber；The weight of the liposoluble vitamin accounts for the 10%~40% of vitamin gross weight；Institute The ratio for stating n-6 aliphatic acid and n-3 aliphatic acid in fat is 4:1.

Embodiment 3

Burn tailored version clinical nutrition formula of the present invention includes PURE WHEY 10.4g, soybean protein isolate 5.2g, whole milk powder 12g, dried whole-egg 0.33g, colostrum 0.16g, taurine 0.12g, ocean fish oligopeptide 0.1g；Olive oil 2.77g, soybean oil 4.48g, coconut oil 2.77g, perilla herb oil 0.64g, medium chain triglyceride 0.21g；Maltodextrin 35g, rock sugar 6.2g, tapioca 7.49g；Dietary fiber 3.5g；Calcium 0.44g, phosphorus 0.23g, potassium 0.08g, sodium 0.14g, magnesium in macroelement 0.19g；Iron 0.015g, iodine 0.00014g, zinc 0.13g in trace element；Vitamin A 0.0005g, beta carotene 0.000057g, vitamin D₃0.000002g, vitamin E 0.01g；Vitamin B₁0.001g, vitamin B₂0.001g, dimension Raw element B₆0.001g, vitamin B₁₂0.000003g, vitamin C 0.188g, pantothenic acid 0.005g, folic acid 0.000165g, nicotinic acid 0.0161g；Red bean powder 0.33g；Peppermint 0.17g, Poria cocos 0.17g, pawpaw 0.17g, dandelion 0.17g, spina date seed 0.17g, gold Honeysuckle flower 0.17g；L-cn 0.63g in natural plants compound,；Phytosterol 0.05g in new resource food；Wherein, it is described Dietary fiber is all water-soluble dietary fiber；The weight of the liposoluble vitamin accounts for the 10%~40% of vitamin gross weight； The ratio of n-6 aliphatic acid and n-3 aliphatic acid is 4 in the fat:1.

Embodiment 4

The preparation method of the burn tailored version clinical nutrition formula containing embodiment 1- embodiments 3 is as follows：

1) powdered oil (powder fat) is prepared：

A) the wall material aqueous solution is prepared：Take 8 grams of maltodextrin, 4 grams of soybean protein isolate, 11 grams of whole-fat milk powder, dietary fiber 2 Gram (resistant dextrin), 0.5 gram of inulin, 5 grams of PURE WHEY, 0.5 gram of oligoisomaltose, 1 gram of fibre and soya, Arabic gum 0.2 gram, 0.5 gram of lactose, 2 grams of candy sugar powder, 50 milliliters of water stirs and (has ready conditions and heat while stirring to 60 DEG C, kept for 30 points Room temperature is cooled to after clock).

B) monoglyceride taken 0.1 gram (total solid concentration be 0.2%) is uniform to be dissolved in (olive oil in 10.2 milliliters of greases 2.6 milliliters, 4.2 milliliters of soybean oil, 2.6 milliliters of coconut oil, 0.6 milliliter of perilla herb oil, 0.2 milliliter of medium chain triglyceride).

C) Tween 80 is taken into 0.1 gram (total solid concentration is 0.2%) to be uniformly dissolved in the wall material aqueous solution.

D) the wall material aqueous solution of the mixed plant grease with addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed.

E) addition stabilizer agar is taken after 0.1 gram (total solid concentration be 0.2%) enter mixed solution, is settled to water 200 milliliters (total solid concentration is 25%), disperses at a high speed 2 minutes under 20000r/min.

F) homogenization pressure is 25MPa, and homogeneous 3 times (every time 5 minutes) is obtained homogeneous emulsion.

G) obtained emulsion is spray-dried, EAT is 195 DEG C, leaving air temp is 80 DEG C.Collect powder Grease (powder fat).

2) integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, it is 3~8 times of raw material weight of water to add weight, immersion is carried out 3~4 hours, then to soak 30~60min of decoction is carried out, filtering removal raw material is left and taken decoction liquor, decoction liquor is spray-dried, with 60~80 mesh sieves point Prepare integration of drinking and medicinal herbs component powders；

3) vitamin powder is prepared：Using the liposoluble vitamin of predetermined weight number as core, from carragheen, I Primary glue carries out 2 emulsifying homogeneous treatment under high pressure as wall material, and the emulsifying homogeneous time is 10~15min, is then sprayed It is instantaneous to dry, prepare liposoluble vitamin powder with 60~80 mesh sieves point；Using the water soluble vitamin of predetermined weight number as Core, from maltodextrin, lipoprotein as wall material, is well mixed, and spraying is instantaneous to be dried, and is prepared with 60~80 mesh sieves point water-soluble Property vitamin powder；

4) by the protein and amino acid of predetermined weight, nucleotides, carbohydrate, dietary fiber, macroelement, micro Element, meals elite, natural plants compound and new resource food are prepared into the powder that particle diameter is 150~250 μm respectively；

5) by step 1)~step 4) obtained by powder sequentially add the mixer of cone-type mixer or other forms and mix Uniformly prepared formula mixture is closed, it is standby by after sterilization processing；

6) according to conventional technical means by step 5) in formula mixture be prepared into nutrient powder, nutrition emulsion, capsule, At least one in tablet, pill or oral liquid.

In step 6) in, optionally increase appropriate food thickening agent and food additives.The food thickening agent It is at least one in guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum, it is described Food additives are at least one in Aspartame, flavoring essence spices, brown sugar；More preferably carragheen, Arabic gum, Guar Glue, Aspartame, flavoring essence spices.

Aforesaid operations step is both needed to be carried out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent from producing The danger of green powder blast.

Embodiment 5

1) the tailored version clinical nutrition that the present invention is provided is formulated to Mouse Acute Toxicity and chronic toxicity test；

Acute toxicity test in mice：The nutrient powder feeding mice that Bian is prepared with the embodiment of the present invention 1~3, Continuous Observation 14 My god, dead and undue toxicity reaction is had no during experiment, after off-test, put to death mouse, Dissection test mouse, observation liver, kidney, Spleen, stomach, the heart, lung and intestines, are showed no abnormal change.By standard of acute toxicity, the sample belongs to nontoxic level.

Murine chronic toxicity test：The nutrient powder feeding mice that Bian is prepared with the embodiment of the present invention 1~3, continuously feeds 90 My god, the mouse behavioral activity of nutrient powder prepared by the result of the test feeding embodiment of the present invention 1~3 is normal, and drinking-water of ingesting is normal, body Weight is normal to be increased, and blood parameters and hematology fluctuate in normal range (NR), and routine urinalysis and marrow index are in normal model Interior fluctuation is enclosed, internal organs no abnormality seen is organized, generally speaking has no that toxicity reacts, from above-mentioned experiment, prepared by the present invention matches somebody with somebody Square product is safe and nontoxic.

2) the tailored version clinical nutrition that the present invention is provided is formulated on the anti-infectious influence of mouse burnt degree；

Take the embodiment of the present invention 1~3 preparation nutrient powder tested, while set comparative example 1, comparative example 2, blank group and Control group, comparative example 1 is adopted using nutrient powder prepared by amino acid and nucleotides, comparative example 2 is deleted in the nutrient formulation of embodiment 2 With the nutrient powder that the preparation of integration of drinking and medicinal herbs composition is deleted in the nutrient formulation of embodiment 2.

Kunming mice 32 is taken, male and female half and half are randomly divided into 2 groups, every group 16.By staphylococcus aureus (CMCC26112), beta hemolytic streptococcus (CMCC32210) is seeded in beef extract soup fluid nutrient medium, puts 37 DEG C of cultures Case 18h.It is 10 with normal saline dilution^-1~10^-8The bacterium solution of concentration.By the staphylococcus aureus of each concentration, hemolytic Streptococcus, Diplococcus pneumopniae, haemophilus influenzae are according to 0.5ml/ dosage, difference intraperitoneal injection infecting mouse.Observation mouse Death state in 5d, tests out the minimum lethal dose (MLD) that test strain causes the death of animal 100%.

Minimum lethal dose (MLD) of the experiment bacterial strain of table 1 to mouse

Kunming mice 140 is taken respectively, and male and female half and half are randomly divided into 14 groups, every group 10, carry out the infection of each strain The dead Protection of induced mice.1~embodiment of embodiment 3,2 groups of 1~comparative example of comparative example are according to dosage 1000mg/kg/ Day gavages, blank group isometric physiological saline gavage, control group 0.4g/kg Amoxicillins gavage.After continuous 3d, each group In the 4th day, according to minimum lethal dose (MLD) intraperitoneal injection different strains.According to preceding dose, it is further continued for giving each group mouse Gavage 3d.After observed and recorded infection in 7d each group mouse death toll, calculate the death rate.

Respectively protective effect of the formula to the death of infection of staphylococcus aureus induced mice of table 2

The respectively formula protective effect dead to beta hemolytic streptococcus infection induced mice of table 3

Experiment shows 1~embodiment of embodiment 3,2 groups of 1~comparative example of comparative example to staphylococcus aureus, beta hemolysis Property streptococcal infection induced mice death has different degrees of protective effect.

3) the tailored version clinical nutrition that the present invention is provided is formulated the influence to mouse burnt degree healing state；

The nutrient powder for taking the preparation of the embodiment of the present invention 1~3 is tested, while setting comparative example 1, comparative example 2, blank Group, using nutrient powder prepared by amino acid and nucleotides is deleted in the nutrient formulation of embodiment 2, comparative example 2 is using real for comparative example 1 Apply the nutrient powder of deletion integration of drinking and medicinal herbs composition preparation in the nutrient formulation of example 2, blank control group gavage chow diet.

Take kunming mice 140 respectively, male and female half and half are randomly divided into 7 groups, every group 20, to the same portion of each mouse Position carries out slight burns, and burn surface area is 3 × 3cm, then carries out normal therapeutic to each mouse.Outside normal therapeutic, implement Example 1~3, the nutrient powder of comparative example 1~2 are persistently taken to wound healing, blank according to dosage 1000mg/kg/day gavages Control group feeding chow diet is to wound healing.For burned mice, judging the standard of drug effect has the sense of healing time, wound Dye situation, its experimental result is as shown in table 3.

The experimental result of the wound healing of table 3

As seen from the above table, the integration of drinking and medicinal herbs component and dietary fiber of present invention addition, seek with protein, carbohydrate etc. Synergy well is there occurs between foster element, it has adjuvant treatment effect to fire victim；In addition, by with comparative example 1 and comparative example 2 be compared discovery, fire victim is anti-infective and wound for improving for amino acid, nucleotides and integration of drinking and medicinal herbs composition Mouth healing is essential, and it complements each other with other components of the present invention, gives full play to respective effect, could obtain excellent Effect.

Specific embodiment of the invention has been described in detail above, but it is only used as example, and the present invention is not intended to limit In particular embodiments described above.To those skilled in the art, any equivalent modifications carried out to the practicality and replace In generation, is also all among scope of the invention.Therefore, the equalization made without departing from the spirit and scope of the invention is converted and repaiied Change, all should be contained within the scope of the invention.

Claims

1. a kind of burn tailored version clinical nutrition is formulated, it is characterised in that including following component：Protein and amino acid, nucleosides Acid, fat, carbohydrate, dietary fiber, macroelement, trace element, vitamin, meals elite, integration of drinking and medicinal herbs composition, day Right plant compound and new resource food；

Wherein, the amino acid includes Glu, L-arginine, taurine；

Wherein, the integration of drinking and medicinal herbs composition includes peppermint, Poria cocos, pawpaw, dandelion, spina date seed, honeysuckle.

2. a kind of burn tailored version clinical nutrition according to claim 1 is formulated, it is characterised in that also thickened including food Agent and food additives, the food thickening agent be guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, At least one in gelatin, Arabic gum, the food additives be Aspartame, flavoring essence spices, brown sugar at least It is a kind of.

3. a kind of burn tailored version clinical nutrition according to claim 1 is formulated, it is characterised in that n-6 in the fat The ratio of aliphatic acid and n-3 aliphatic acid is 4:1~2.

4. a kind of burn tailored version clinical nutrition according to claim 1 is formulated, it is characterised in that the vitamin is water Soluble vitamin and liposoluble vitamin, the weight of the liposoluble vitamin account for the 10%~40% of vitamin gross weight.

5. a kind of burn tailored version clinical nutrition formula according to claim 1, it is characterised in that the dietary fiber is Water-soluble dietary fiber.

6. a kind of burn tailored version clinical nutrition according to claim 1 is formulated, it is characterised in that the weight of the component Number is：Protein and 20~40 parts of amino acid, 0~1 part of nucleotides, 10~20 parts of fat, 30~60 parts of carbohydrate, meals 2~8 parts of fiber of food, 0.6~1.2 part of macroelement, 0.05-0.2 parts of trace element, 0.1~0.3 part of vitamin, meals elite 0.2~0.5 part, 0.2~3 part of integration of drinking and medicinal herbs composition, 0.1-1 parts and new resource food 0.01-0.2 of natural plants compound Part.

7. a kind of burn tailored version clinical nutrition formula according to claim 6, it is characterised in that the integration of drinking and medicinal herbs into The parts by weight of each component are as follows in point：0~1 part of peppermint, 0~1 part of Poria cocos, 0~1 part of pawpaw, 0~1 part of dandelion, spina date seed 0~1 part, 0~1 part of honeysuckle.

8. the preparation method that a kind of burn tailored version clinical nutrition as any one of claim 1~7 is formulated, its feature It is to comprise the following steps：

Step one, by the protein and amino acid of predetermined weight number, nucleotides, fat, carbohydrate, dietary fiber, often Secondary element, trace element, vitamin, integration of drinking and medicinal herbs composition, natural plants compound and new resource food prepare granulating respectively Footpath is 150~250 μm of powder；

Step 3, using in the step 2 be well mixed powder be prepared into nutrient powder, nutrition emulsion, capsule, tablet, ball At least one in agent or oral liquid；

Wherein, the raw material of the integration of drinking and medicinal herbs composition crushed, water extraction concentration, and concentrate carried out into spray drying be made medicine Eat homologous component powders；

9. the preparation method that a kind of burn tailored version clinical nutrition as any one of claim 1~7 is formulated, its feature It is to comprise the following steps：

Step 1) prepare the protein containing predetermined weight number and amino acid, nucleotides, fat, carbohydrate, meals fibre The former material of dimension, macroelement, trace element, vitamin, integration of drinking and medicinal herbs composition, natural plants compound and new resource food Material, according to the physical behavior of raw material, adds successively according to sequencing, is stirred while addition, and raw material is obtained Mixed emulsion；

Step 2) by step 1) mixed emulsion that obtains carries out emulsifying homogeneous, concentrating sterilizing, obtains concentrate；

Step 3) by step 2) concentrate that obtains is spray-dried, sieved, and is prepared into powder, and above-mentioned powder is prepared into At least one in nutrient powder, nutrition emulsion, capsule, tablet, pill or oral liquid.