CN106490605A

CN106490605A - A kind of hypertension of pregnancy tailored version clinical nutrition formula and preparation method thereof

Info

Publication number: CN106490605A
Application number: CN201611209082.6A
Authority: CN
Inventors: 尤俊; 杨升平; 季敬东
Original assignee: Shanghai Olympic Medical Biotechnology Co Ltd
Current assignee: Shanghai Olympic Medical Biotechnology Co Ltd
Priority date: 2016-12-23
Filing date: 2016-12-23
Publication date: 2017-03-15

Abstract

The present invention relates to a kind of hypertension of pregnancy tailored version clinical nutrition formula and preparation method thereof, the present invention adopts 25 35 parts of protein, 8 15 parts of fat, 35 45 parts of carbohydrate, 38 parts of dietary fibers, 0.6 1.2 parts of macroelements, 0.01 0.03 parts of trace elements, 0.005 0.02 parts of liposoluble vitamins, 0.08 0.2 parts of water soluble vitamins, 0.5 5 parts of meals elite, 0.5 5 parts of integration of drinking and medicinal herbs compositions, 0.1 1 parts of natural plants compounds and 0.1 0.4 parts of new resource foods, wherein described integration of drinking and medicinal herbs composition is selected from chrysanthemum, the sophora bud, lotus leaf, matrimony vine, oyster, emblic, at least one in the root of kudzu vine；The previously prepared powdering of each component, wherein fat prepare powdered oil using micro-capsule embedding techniques.By screening and the proportioning of said components, nutrient formulation of the present invention can provide comprehensive nutritional need for pregnancy-induced hypertension patients, simultaneously by adding the component with blood pressure reduction effect, auxiliary reduces the pressure value of the hypertension of pregnancy, reduce the risk of the hypertension of pregnancy, it is ensured that needed for the growth of fetus and normal development.

Description

A kind of hypertension of pregnancy tailored version clinical nutrition formula and preparation method thereof

Technical field

The present invention relates to special medicine purposes formula food field, and in particular to a kind of clinical battalion of hypertension of pregnancy tailored version Support formula and preparation method thereof.

Background technology

Hypertension of pregnancy synthetic disease is the gestational period distinctive disease, including gestation hypertension, preeclampsia and eclampsia Deng, be mainly shown as blood pressure raise and albuminuria, each internal organs of pregnant woman can be endangered.Generally major part gestational patients only have slight Symptom, but the consequence of some Disadvantage pregnancies can be caused, including premature labor, FGR, when serious, may result in foetal death, tire Disk early stripping etc..In China, the incidence of disease about 9.4% of the hypertension of pregnancy, foreign countries about 7%～12%；Majority of cases is in gestation 20 There are the symptoms such as hypertension, albuminuria in Zhou Yihou, disappeared therewith after childbirth.The disease has a strong impact on baby's health, is pregnant Puerpera and the main cause of perinatal feruses disease rate and the death rate.

With increasing for growth in the living standard, bad diet style and lying-in woman advanced in years, the gestation hypertension incidence of disease by Year rises.The mode for the treatment of gestation hypertension is mainly Chinese medicine preparation or dietotherapy, such as Chinese patent at present CN103893548A discloses a kind of Chinese medicine preparation for treating gestation hypertension disease, its raw material group by following percentage by weight Into：Ligusticum wallichii 10-20%, root of kudzu vine 10-20%, parasitic loranthus 6-12%, bighead atractylodes rhizome 8-15%, sealwort 6-12%, hawthorn 10-20%, summer Withered grass 6-12%, cucumber stem 6-12%, Poria cocos 8-16%, using the standby Chinese medicine capsules of this patent system to hypertension of pregnancy safety Effectively, lossless fetus, but its nutrient content is not comprehensive.

In recent years report thinks, nutrient imbalance is closely related with PIH generation, therefore affects which by nutritional intervention Raw, development, is a feasible approach.At present, pathogenic factor diseases, such as hypertension relevant with nutrition etc., can pass through nutrition Intervene and reduce generation, delay of progression, confirmed by clinical practice.But have no applied nutrition intervening measure prevention preeclampsia so far Research report.For this purpose, developing the special clinical nutrition formula of the hypertension of pregnancy, it is to prevent or alleviate preeclampsia, ensure that mother and baby is good for The important channel of health.

Content of the invention

It is an object of the invention to overcoming defect of the prior art, there is provided a kind of hypertension of pregnancy tailored version clinical nutrition Formula and preparation method thereof, hypertension of pregnancy tailored version clinical nutrition formula of the present invention is provided for pregnancy-induced hypertension patients Comprehensively nutritional support, payes attention to comprehensive demand of the patient to basic energy, basic nutrition and essential trace element；And in this base On plinth, add some hypotensive integration of drinking and medicinal herbs composition, natural plants compound and new resource foods, steady pregnant woman's blood pressure, solution Certainly the problem of pregnancy-induced hypertension patients hypertension, realizes mother and sons' health safety.

For achieving the above object, the present invention is adopted the following technical scheme that：

On the one hand, the present invention provides a kind of hypertension of pregnancy tailored version clinical nutrition formula, including following parts by weight Component：25-35 part protein, 8-15 parts fat, 35-45 part carbohydrate, 3-8 part dietary fibers, 0.6-1.2 parts constant unit Element, 0.01-0.03 parts trace element, 0.005-0.02 part liposoluble vitamins, 0.08-0.2 part water soluble vitamins, 0.5-5 Part meals elite, 0.5-5 part integration of drinking and medicinal herbs compositions, 0.1-1 part natural plants compounds and 0.1-0.4 part new resource foods.

In order to further optimize above-mentioned technical proposal, the technical measures taken by the present invention also include：

Preferably, the protein is selected from PURE WHEY, soybean protein isolate, whole milk powder, dried whole-egg, newborn iron egg In vain, at least one in colostrum, amino acid, protein peptides；

Wherein, the amino acid is selected from 1B-Pidolidone, mono- glutamic acid of L, mono- arginine of L, L-Trp, L mono- At least one in glutamine, taurine, mono- valines of L, ILE, mono- leucines of L；The protein peptides are selected from soybean In oligopeptide, wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide powder, laughable peptide, amino peptide, ovalbumin peptide at least A kind of.

Preferably, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structures At least one in fat, DHA, EPA, ARA, phosphatide, more specifically described fat include safflower seed oil, walnut oil, peanut oil, Soybean oil, Ah's glycerine, olive oil, tea oil, oil and fat of sacha inchi, olive oil, coconut oil, perilla herb oil, deep sea fish oil, cupu oil, palm Oil, butter, cream, lard, medium chain triglyceride, lecithin.

Preferably, the carbohydrate is included in fructose, rock sugar, lactose, maltodextrin, tapioca, resistant starch At least two.

Preferably, the dietary fiber comprising inulin, konjaku flour, galactooligosaccharide, FOS, oligoisomaltose, At least one in soybean polyoses, cyclodextrin, resistant dextrin, fibre and soya.

Preferably, the macroelement is selected from calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, K-IAO, sodium citrate With at least one in magnesium gluconate.

Preferably, the trace element is selected from ferrous gluconate, KI, zinc gluconate, sodium selenite, glucose At least one in sour copper, chromium sulfate, manganese gluconate and sodium molybdate.

Preferably, the liposoluble vitamin is selected from vitamin A, beta carotene, vitamine D3, vitamin E, vitamin At least one in K1.

Preferably, the water soluble vitamin is selected from vitamin B1, vitamin B2, vitamin B6, vitamin B12, dimension life At least one in plain C, pantothenic acid, folic acid, nicotinic acid, choline, inositol, biotin.

Preferably, the meals elite is selected from cereal, beans, potato class, greengrocery, Homonemeae, nut-seed class, fishes and shrimps At least one in class, poultry meat, fruits；Wherein described cereal mainly by rice meal, millet powder, black rice flour, coixlacrymajobi powder, One kind in corn flour, wheat germ powder, oatmeal, buckwheat or at least two compositions, the beans is mainly by peameal, green One kind in bean powder, black bean powder, red bean powder, soy meal or at least two compositions, the potato class are mainly made up of common yam rhizome powder, described Vegetable powder is mainly by one kind in carrot meal, white radish powder, pumpkin powder, spinach powder, tomato meal, broccoli powder, balsam pear powder or several Composition is planted, mainly by one or more in mushroom powder and white fungus powder, the nut-seed class is mainly lotus seeds to the Homonemeae Powder, the fish and shrimp are mainly made up of one or more in salmon powder and cod meal, the poultry meat mainly by In chicken meal, powdered beef one or more composition, the fruits mainly by red date powder, longan powder, apple powder, cherry powder, One or more compositions in oranges and tangerines powder, snow pear powder；It is highly preferred that the meals elite by oatmeal, buckwheat, red bean powder, Carrot meal, salmon powder, snow pear powder composition.

Preferably, the integration of drinking and medicinal herbs composition is selected from chrysanthemum, the sophora bud, lotus leaf, matrimony vine, oyster, emblic, the root of kudzu vine extremely Few one kind.

Preferably, the natural plants compound is selected from l-cn, Glucosamine, FOS, lutein, plant At least one in sterol, lycopene, resveratrol, allicin；The natural plants compound is more preferably l-cn.

Preferably, the new resource food is selected from first milk basic protein, GABA, chitosan oligosaccharide, eucommia Bark male flower, bamboo At least one in leaf flavones, CPP, avenabeta glucosan, yeast beta-dextran, leaf of Moringa, xylo-oligosaccharide；Institute State new resource food and be more preferably GABA.

Preferably, in the integration of drinking and medicinal herbs composition, the parts by weight of each component are as follows：Chrysanthemum 0-1 parts, sophora bud 0-1 parts, lotus Leaf 0-1 parts, matrimony vine 0-1 parts, oyster 0-1 parts, emblic 0-1 parts, root of kudzu vine 0-1 parts.

Preferably, the good protein weight provided in the protein and amino acid accounts for the 70% of gross protein weight More than.

Preferably, in the fat, the ratio of n-6 aliphatic acid and n-3 aliphatic acid is 3～4:1.

On the other hand, the present invention relates to a kind of by above-mentioned hypertension of pregnancy tailored version clinical nutrition formula prepare product, Including nutrient powder, nutrition emulsion, capsule, tablet, pill, oral liquid etc..

Finally, the present invention is also provided and a kind of the hypertension of pregnancy tailored version clinical nutrition formula is prepared into nutrient powder Method, its comprise the steps：By the protein of predetermined weight number, fat, carbohydrate, dietary fiber, macroelement, Trace element, liposoluble vitamin, water soluble vitamin, meals elite, integration of drinking and medicinal herbs composition, natural plants compound and new Resource food is prepared into the powdery that particle diameter is 100～300 μm respectively, and the powdery is well mixed, and obtains hypertension tailored version Complete nourishing powder, filling after sterilization processing in packaging bag or is placed directly within pail pack；Wherein, the fat is using micro- Capsule embedding techniques makes powder, and the integration of drinking and medicinal herbs composition makes powder by crushing, crossing 60-80 mesh sieves.

The present invention also provides a kind of side that the hypertension of pregnancy tailored version clinical nutrition formula is prepared into nutrition emulsion Method, its comprise the steps：

Step one, by the protein of predetermined weight number, fat, carbohydrate, dietary fiber, macroelement, micro Element, liposoluble vitamin, water soluble vitamin, meals elite, integration of drinking and medicinal herbs composition, natural plants compound and new resources Food is prepared into the powdery that particle diameter is 100～300 μm respectively；Wherein, the fat makes powder using micro-capsule embedding techniques, The integration of drinking and medicinal herbs composition makes powder by crushing, crossing 60-80 mesh sieves；

Step 2, protein powder is dissolved in a certain amount of water abundant aquation, obtains protein aqueous solution, then by carbon Hydrate powder, macroelement powder, micro- powder, water soluble vitamin powder are dissolved in protein aqueous solution, Obtain aqueous phase solution；

Step 3, by the fat powder after micro-capsule embedding treatment, liposoluble vitamin powder, meals elite powder, medicine food Homologous component powders, natural plants compound powder sequentially add the aqueous phase solution of gained in step 2, and carry out strong agitation, Add emulsifying agent and thickener, obtain concentrated emulsions；

Step 4, in the concentrated emulsions described in step 3 add scheduled volume water and stir, while removing skim-coat Foam, obtains emulsion, then by emulsion homogeneous under high pressure, in high-temperature sterilization, is cooled to room temperature, and nutrition emulsion is obtained, and will Nutrition emulsion is filling in packaging bag.

In above two preparation method, the specific implementation step of micro-capsule embedding techniques is as follows：By fat, emulsifying agent, wall Material prepares emulsion with water mixed dissolution；After by the stirring mixing of above-mentioned emulsion, emulsifying homogeneous process is carried out, is then sprayed Dry, screening prepares powdered oil, and powdered oil is compared with conventional grease, its dispersiveness, water solubility, emulsibility, non-oxidizability All improve a lot；

Wherein, the emulsifying agent is selected from fatty acid glyceride (glyceride), methyl glycol fatty acid ester (propylene glycol ester), sorb One or more in glycan fatty acid ester (sorbitan acid), sucrose fatty ester (sucrose ester), lecithin；The wall material choosing From sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, guar gum, maltodextrin, lipoprotein, corn syrup In one or more.

Using the integration of drinking and medicinal herbs composition for including chrysanthemum, the sophora bud, lotus leaf, matrimony vine, oyster, emblic, the root of kudzu vine in the present invention, on Stating composition has definite, safe blood pressure reduction effect.

Chrysanthemum has hypotensive, elimination cancer cell, coronary artery dilator and antibacterial effect, and drinking for a long time to increase human body Calcareous, regulation myocardial function, reduction cholesterol；

The sophora bud contains abundant Quercetin and rutin, with hypotensive, reduction capillary permeability and fragility, antithrombotic Deng effect.Wherein, Quercetin has than the effect of vitamin C more preferable endothelium-dependent relaxation vasodilator；Incidence of CHD can be reduced And fatal rate, reduce atherosclerotic and coronary artery disease；Strengthen coronary artery circulation, prevent thrombosis；And rutin Can adjust and reduce fragility of blood vessels, reduce vasopermeability, keep and recover the normal elasticity of capillary, prevent angiorrhoxis, Auxiliary treatment for high blood pressure.Rutin in the sophora bud produces the blood of endothelium-dependent relaxation by NO- guanylates enzymatic pathway Pipe diastole is acted on, can dose-dependant ground antagonism PAF and the specific binding of rabbit platelet membrane receptor, suppress PAF mediation rabbit blood little Plate is sticked and is raised with free Ca2+ concentration in PMNs, and which passes through to suppress paf receptor activation, and then blocks the reaction of PAF inductions, from And play antithrombotic effect；

Lotus leaf main component have Nuciferine, citric acid, malic acid, gluconic acid, oxalic acid, butanedioic acid and other anti-have silk point The alkaline components of effect are split, there is antipyretic, antibacterial, spasmolysis, modern pharmacological research to show for which, lotus leaf has hypotensive, drop Blood fat, effect of fat-reducing；

There is matrimony vine nourishing the liver, nourshing kidney, effect of moistening lung, the LBP-X which contains there is promotion immunity, anti-aging, resist and swell The effects such as knurl, removing free radical, antifatigue, radioresistance, liver protection, reproductive function protection and improvement；

In oyster, contained abundant Taurine has obvious hepatic cholagogic effect, and this is also preventing and treating pregnancy period hepatic bile stasis of blood product The good medicine of disease, contained abundant trace element and glycogen, to promoting growing, rescuing pregnant woman anemia and to pregnant woman's for fetus Antisecosis is beneficial to, and which can also reduce and reduce harm of the hazardous trace elements cadmium to human body, can efficiently control and hinder High blood pressure caused by disconnected cadmium, is conducive to improving and prevents and treats high blood pressure, prevent or alleviate hypertensive encephalopathy (as cerebral hemorrhage, Cerebral thrombus) generation；

Emblic has clearing heat and cooling blood, and food digesting stomach fortifying is hypotensive, reducing blood lipid, and treatment cardiovascular and cerebrovascular disease has effect well Really；Emblic fruit taste acid micro-puckery, clearing heat and cooling blood, digestion-promoting spleen-invigorating promote the production of body fluid to quench thirst, and which cures mainly blood-head blood stasis, indigestion, abdomen Swollen, cough, laryngalgia, dry and vitamin C deficiency.In Tibetan medicine, emblic cures mainly sick Baconic, red bar disease, blood disease, hypertension Disease etc.；

The root of kudzu vine has rising Yang expelling pathogenic factors from muscles and skin, promoting eruption antidiarrheal, effect that relieving restlessness is quenched the thirst.Modern pharmacological research shows contained by the root of kudzu vine The total Pueraria lobota ketone of the root of kudzu vine and Puerarin significantly reduce can plasma renin activity and angiotensins, drop in blood pressure；

Compared with prior art, the invention has the advantages that：

(1) present invention adds the integration of drinking and medicinal herbs composition with hypotensive effect, and its each component complements each other, determined curative effect, tool There is safe blood pressure reduction effect, which can provide required nutrient content for pregnancy-induced hypertension patients with other raw materials again jointly, protect The normal development of card fetus；

(2) present invention adds the new resource food of the GABA with antihypertensive effect, and Gabanergic is direct The vasomotor center of spinal cord is acted on, blood vessel dilatation is effectively facilitated, the purpose of blood pressure is reduced.

(3) present invention prepares powdered oil using micro-capsule embedding techniques so that powdered oil has preferable mobility, easily In being well mixed with other powdered components；And using after micro-capsule embedding techniques, grease is embedded in wall material, so as to avoid with The contact of air to strengthen non-oxidizability, so as to the maximum effect of health grease can be played.

(4) raw material of hypertension of pregnancy tailored version clinical nutrition formula of the present invention is made in preparation process in advance For the powder into 100～300 μm, this is caused when finished product is prepared, and each nutrition composition can be well mixed, it is ensured that in unit volume Each nutrition composition content essentially identical, while when liquid type preparation is prepared, each nutrition composition can be fully dispersed and complete It is dissolved in solvent, prevents solids of sedimentation in liquid, occur, effect of finished product product has been effectively ensured.

Specific embodiment

The present invention provides a kind of hypertension of pregnancy tailored version with suppression blood glucose rise for pregnancy-induced hypertension patients Enteral clinical nutrition is filled a prescription, including the component of following parts by weight：25-35 part protein, 8-15 parts fat, 35-45 part carbon water Compound, 3-8 part dietary fibers, 0.6-1.2 part macroelements, 0.01-0.03 parts trace element, 0.005-0.02 parts are fat-soluble Vitamin, 0.08-0.2 part water soluble vitamins, 0.5-5 part meals elite, 0.5-5 part integration of drinking and medicinal herbs compositions, 0.1-1 parts are natural Plant compound and 0.1-0.4 part new resource foods.

With reference to embodiment, the specific embodiment of the present invention is further described.Following examples are only used for more Plus technical scheme is clearly demonstrated, and can not be limited the scope of the invention with this.

Embodiment 1

Hypertension of pregnancy tailored version clinical nutrition formula of the present invention includes that PURE WHEY 11.3g, soybean separate Albumen 4.33g, hydrolysis Isin glue collagen 0.66g, whole milk powder 12g, dried whole-egg 0.33g, colostrum 0.16, taurine 0.11g, Ocean fish oligopeptide powder 0.266g；Olive oil 1.77g, soybean oil 4.48g, coconut oil 1.77g, perilla herb oil 2.64g, medium chain triglyceride Three ester 0.213g；Maltodextrin 9.28g, rock sugar 8g, lactose 0.67g, tapioca 10g, resistant starch 13.33g；Dietary fiber Selected from inulin, konjaku flour, galactooligosaccharide, FOS, oligoisomaltose, soybean polyoses, cyclodextrin, resistant dextrin, big At least one in beans fiber, its gross mass be 4.99g, wherein water-soluble dietary fiber 3.83g, fat-soluble dietary fiber 1.16g；Calcium 0.4g, phosphorus 0.25g, potassium 0.08g, sodium 0.02g, magnesium 0.15g in macroelement；Iron 0.011g, iodine in trace element 0.00014g, zinc 0.007g；Vitamin A 0.0006g, beta carotene 0.000057g, vitamin D in liposoluble vitamin₃ 0.000001g, vitamin E 0.009g；Cobastab in water soluble vitamin₁0.001g, Cobastab₂0.001g, vitamin B₆0.001g, Cobastab₁₂0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, folic acid 0.000165g, nicotinic acid 0.0165g；Oatmeal 0.5g, buckwheat 0.5g, red bean powder 0.5g, carrot meal 0.5g, salmon 0.5g, snow pear powder 0.5g；Medicine Food is with chrysanthemum 0.5g, sophora bud 0.5g, lotus leaf 0.56g, matrimony vine 0.5g, oyster 0.5g, emblic 0.5g, the root of kudzu vine in derived components 0.5g；L-cn 0.633g in natural plants compound；GABA 0.2g in new resource food.

Embodiment 2

Hypertension of pregnancy tailored version clinical nutrition formula of the present invention includes that PURE WHEY 11.3g, soybean separate Albumen 4.33g, hydrolysis Isin glue collagen 0.66g, whole milk powder 12g, dried whole-egg 0.33g, colostrum 0.16, taurine 0.11g, Ocean fish oligopeptide powder 0.266g；Olive oil 1.77g, soybean oil 4.48g, coconut oil 1.77g, perilla herb oil 2.64g, medium chain triglyceride Three ester 0.213g；Maltodextrin 10.78g, rock sugar 8g, lactose 0.67g, tapioca 10g, resistant starch 13.33g；Meals are fine Dimension selected from inulin, konjaku flour, galactooligosaccharide, FOS, oligoisomaltose, soybean polyoses, cyclodextrin, resistant dextrin, At least one in fibre and soya, its gross mass be 4.99g, wherein water-soluble dietary fiber 3.83g, fat-soluble dietary fiber 1.16g；Calcium 0.4g, phosphorus 0.25g, potassium 0.08g, sodium 0.02g, magnesium 0.15g in macroelement；Iron 0.011g, iodine in trace element 0.00014g, zinc 0.007g；Vitamin A 0.0006g, beta carotene 0.000057g, vitamin D in liposoluble vitamin₃ 0.000001g, vitamin E 0.009g；Cobastab in water soluble vitamin₁0.001g, Cobastab₂0.001g, vitamin B₆0.001g, Cobastab₁₂0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, folic acid 0.000165g, nicotinic acid 0.0165g；Oatmeal 0.33g, buckwheat 0.33g, red bean powder 0.166g, carrot meal 0.166g, salmon 0.166g, snow pear Powder 0.166g；Chrysanthemum 0.5g, sophora bud 0.5g, lotus leaf 0.56g, matrimony vine 0.5g, oyster 0.5g, emblic in integration of drinking and medicinal herbs composition 0.5g, root of kudzu vine 0.5g；L-cn 0.633g in natural plants compound；GABA 0.2g in new resource food.

Embodiment 3

Hypertension of pregnancy tailored version clinical nutrition formula of the present invention includes that PURE WHEY 11.3g, soybean separate Albumen 4.33g, hydrolysis Isin glue collagen 0.66g, whole milk powder 12g, dried whole-egg 0.33g, colostrum 0.16, taurine 0.11g, Ocean fish oligopeptide powder 0.266g；Olive oil 2.77g, soybean oil 4.48g, coconut oil 2.77g, perilla herb oil 0.64g, medium chain triglyceride Three ester 0.213g；Maltodextrin 10.78g, rock sugar 10g, lactose 0.67g, tapioca 10g, resistant starch 13.33g；Meals are fine Dimension selected from inulin, konjaku flour, galactooligosaccharide, FOS, oligoisomaltose, soybean polyoses, cyclodextrin, resistant dextrin, At least one in fibre and soya, its gross mass be 4.99g, wherein water-soluble dietary fiber 3.83g, fat-soluble dietary fiber 1.16g；Calcium 0.4g, phosphorus 0.25g, potassium 0.08g, sodium 0.02g, magnesium 0.15g in macroelement；Iron 0.011g, iodine in trace element 0.00014g, zinc 0.007g；Vitamin A 0.0006g, beta carotene 0.000057g, vitamin D in liposoluble vitamin₃ 0.000001g, vitamin E 0.009g；Cobastab in water soluble vitamin₁0.001g, Cobastab₂0.001g, vitamin B₆0.001g, Cobastab₁₂0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, folic acid 0.000165g, nicotinic acid 0.0165g；Oatmeal 0.33g, buckwheat 0.33g, red bean powder 0.166g, carrot meal 0.166g, salmon 0.166g, snow pear Powder 0.166g；Chrysanthemum 0.2g in integration of drinking and medicinal herbs composition, sophora bud 0.167g, lotus leaf 0.167g, matrimony vine 0.167g, oyster 0.167g, Emblic 0.167g, root of kudzu vine 0.167g；L-cn 0.633g in natural plants compound；Gamma-amino fourth in new resource food Sour 0.16g.

Embodiment 4

Hypertension of pregnancy tailored version clinical nutrition formula of the present invention includes that PURE WHEY 11.3g, soybean separate Albumen 4.33g, hydrolysis Isin glue collagen 0.66g, whole milk powder 12g, dried whole-egg 0.33g, colostrum 0.16, taurine 0.11g, Ocean fish oligopeptide powder 0.266g；Olive oil 2.77g, soybean oil 4.48g, coconut oil 2.77g, perilla herb oil 0.64g, medium chain triglyceride Three ester 0.213g；Maltodextrin 10.78g, rock sugar 10g, lactose 0.67g, tapioca 10g, resistant starch 13.33g；Meals are fine Dimension selected from inulin, konjaku flour, galactooligosaccharide, FOS, oligoisomaltose, soybean polyoses, cyclodextrin, resistant dextrin, At least one in fibre and soya, its gross mass be 4.99g, wherein water-soluble dietary fiber 3.83g, fat-soluble dietary fiber 1.16g；Calcium 0.4g, phosphorus 0.25g, potassium 0.08g, sodium 0.02g, magnesium 0.15g in macroelement；Iron 0.011g, iodine in trace element 0.00014g, zinc 0.007g；Vitamin A 0.0006g, beta carotene 0.000057g, vitamin D in liposoluble vitamin₃ 0.000001g, vitamin E 0.009g；Cobastab in water soluble vitamin₁0.001g, Cobastab₂0.001g, vitamin B₆0.001g, Cobastab₁₂0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, folic acid 0.000165g, nicotinic acid 0.0165g；Oatmeal 0.33g, buckwheat 0.33g, red bean powder 0.166g, carrot meal 0.166g, salmon 0.166g, snow pear Powder 0.166g；Chrysanthemum 0.1g, sophora bud 0.1g, lotus leaf 0.1g, matrimony vine 0.1g, oyster 0.1g, emblic in integration of drinking and medicinal herbs composition 0.1g, root of kudzu vine 0.1g；L-cn 0.633g in natural plants compound；GABA 0.16g in new resource food.

Embodiment 5

Hypertension of pregnancy tailored version clinical nutrition formula of the present invention includes that PURE WHEY 11.3g, soybean separate Albumen 4.33g, hydrolysis Isin glue collagen 0.66g, whole milk powder 12g, dried whole-egg 0.33g, colostrum 0.16, taurine 0.11g, Ocean fish oligopeptide powder 0.266g；Olive oil 2.77g, soybean oil 4.48g, coconut oil 2.77g, perilla herb oil 0.64g, medium chain triglyceride Three ester 0.213g；Maltodextrin 10.98g, rock sugar 10g, lactose 0.67g, tapioca 10g, resistant starch 13.33g；Meals are fine Dimension selected from inulin, konjaku flour, galactooligosaccharide, FOS, oligoisomaltose, soybean polyoses, cyclodextrin, resistant dextrin, At least one in fibre and soya, its gross mass be 4.99g, wherein water-soluble dietary fiber 3.83g, fat-soluble dietary fiber 1.16g；Calcium 0.4g, phosphorus 0.25g, potassium 0.08g, sodium 0.02g, magnesium 0.15g in macroelement；Iron 0.011g, iodine in trace element 0.00014g, zinc 0.007g；Vitamin A 0.0006g, beta carotene 0.000057g, vitamin D in liposoluble vitamin₃ 0.000001g, vitamin E 0.009g；Cobastab in water soluble vitamin₁0.001g, Cobastab₂0.001g, vitamin B₆0.001g, Cobastab₁₂0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, folic acid 0.000165g, nicotinic acid 0.0165g；Oatmeal 0.33g, buckwheat 0.33g, red bean powder 0.166g, carrot meal 0.166g, salmon 0.166g, snow pear Powder 0.166g；Chrysanthemum 0.1g, sophora bud 0.1g, lotus leaf 0.1g, matrimony vine 0.1g, oyster 0.1g, emblic in integration of drinking and medicinal herbs composition 0.1g, root of kudzu vine 0.1g；L-cn 0.633g in natural plants compound.

Embodiment 6

Hypertension of pregnancy tailored version clinical nutrition formula of the present invention includes that PURE WHEY 11.3g, soybean separate Albumen 4.33g, hydrolysis Isin glue collagen 0.66g, whole milk powder 12g, dried whole-egg 0.33g, colostrum 0.16, taurine 0.11g, Ocean fish oligopeptide powder 0.266g；Olive oil 2.77g, soybean oil 4.48g, coconut oil 2.77g, perilla herb oil 0.64g, medium chain triglyceride Three ester 0.213g；Maltodextrin 11.48g, rock sugar 10g, lactose 0.67g, tapioca 10g, resistant starch 13.33g；Meals are fine Dimension selected from inulin, konjaku flour, galactooligosaccharide, FOS, oligoisomaltose, soybean polyoses, cyclodextrin, resistant dextrin, At least one in fibre and soya, its gross mass be 4.99g, wherein water-soluble dietary fiber 3.83g, fat-soluble dietary fiber 1.16g；Calcium 0.4g, phosphorus 0.25g, potassium 0.08g, sodium 0.02g, magnesium 0.15g in macroelement；Iron 0.011g, iodine in trace element 0.00014g, zinc 0.007g；Vitamin A 0.0006g, beta carotene 0.000057g, vitamin D in liposoluble vitamin₃ 0.000001g, vitamin E 0.009g；Cobastab in water soluble vitamin₁0.001g, Cobastab₂0.001g, vitamin B₆0.001g, Cobastab₁₂0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, folic acid 0.000165g, nicotinic acid 0.0165g；Oatmeal 0.33g, buckwheat 0.33g, red bean powder 0.166g, carrot meal 0.166g, salmon 0.166g, snow pear Powder 0.166g；L-cn 0.633g in natural plants compound；GABA 0.16g in new resource food.

Embodiment 7

Hypertension of pregnancy tailored version clinical nutrition formula of the present invention includes that PURE WHEY 11.3g, soybean separate Albumen 4.33g, hydrolysis Isin glue collagen 0.66g, whole milk powder 12g, dried whole-egg 0.33g, colostrum 0.16, taurine 0.11g, Ocean fish oligopeptide powder 0.266g；Olive oil 2.77g, soybean oil 4.48g, coconut oil 2.77g, perilla herb oil 0.64g, medium chain triglyceride Three ester 0.213g；Maltodextrin 11.64g, rock sugar 10g, lactose 0.67g, tapioca 10g, resistant starch 13.33g；Meals are fine Dimension selected from inulin, konjaku flour, galactooligosaccharide, FOS, oligoisomaltose, soybean polyoses, cyclodextrin, resistant dextrin, At least one in fibre and soya, its gross mass be 4.99g, wherein water-soluble dietary fiber 3.83g, fat-soluble dietary fiber 1.16g；Calcium 0.4g, phosphorus 0.25g, potassium 0.08g, sodium 0.02g, magnesium 0.15g in macroelement；Iron 0.011g, iodine in trace element 0.00014g, zinc 0.007g；Vitamin A 0.0006g, beta carotene 0.000057g, vitamin D in liposoluble vitamin₃ 0.000001g, vitamin E 0.009g；Cobastab in water soluble vitamin₁0.001g, Cobastab₂0.001g, vitamin B₆0.001g, Cobastab₁₂0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, folic acid 0.000165g, nicotinic acid 0.0165g；Oatmeal 0.33g, buckwheat 0.33g, red bean powder 0.166g, carrot meal 0.166g, salmon 0.166g, snow pear Powder 0.166g；L-cn 0.633g in natural plants compound.

Embodiment 8

The preparation method of the nutrient powder of the formula of the hypertension of pregnancy tailored version clinical nutrition containing embodiment 1- embodiment 7 is such as Under：

1) powdered oil is prepared：By the fat of predetermined weight with sucrose ester, monoglyceride, maltodextrin, water at 70 DEG C or so Carry out mixed dissolution and prepare emulsion, the wherein consumption of sucrose ester and monoglyceride for emulsion weight 2.5%～5%, water 10～15 times for fat weight of consumption, maltodextrin consumption for emulsion weight 8%～20%；Above-mentioned emulsion is stirred After 2～5min of mixing, carry out 2 emulsifying homogeneous under high pressure and process, the emulsifying homogeneous time is 12～18min；Then sprayed Mist is dried, and prepares powdered oil with 60～80 mesh sieves point；

2) integration of drinking and medicinal herbs component powders are prepared：By the integration of drinking and medicinal herbs composition of predetermined weight be put into pulverizer carry out crushing, mistake 60～80 mesh sieves make integration of drinking and medicinal herbs component powders；

3) by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, the life of fat-soluble dimension Element, water soluble vitamin, meals elite, natural plants compound and new resource food are prepared into particle diameter respectively for 100～300 μm powdery；

4) by step 1)～step 3) obtained by powder be well mixed, to obtain hypertension tailored version complete nourishing powder, Filling after sterilization processing in sterilized packaging bag or it is placed directly within sterilized pail pack.

Aforesaid operations step is both needed to carry out under the protection of inert gas, and such as nitrogen protection, to prevent that powder is quick-fried Fried danger.

Embodiment 9

The preparation method of the nutrition emulsion of the formula of the hypertension of pregnancy tailored version clinical nutrition containing embodiment 1- embodiment 7 As follows：

4) by step 3) in protein powder be dissolved in temperature be 20～25 DEG C, abundant water in the pure water of 280～350g Change 3～15h, obtain in protein aqueous solution, then by step 3) in carbohydrate powder, macroelement powder, micro unit Plain powder, water soluble vitamin powder are dissolved in protein aqueous solution, carry out gentle agitation, add emulsifying agent and thickener, The aqueous phase solution being uniformly mixed；

5) by step 1) in micro-capsule embedding treatment after fat powder, step 2) in prepare liposoluble vitamin powder End, meals elite powder, integration of drinking and medicinal herbs component powders, natural plants compound powder sequentially add the water phase of gained in step 4 Solution, and strong agitation is carried out, the concentrated emulsions being uniformly mixed；

6) in the concentrated emulsions described in step 5,20～25 DEG C, are added, the pure water of 100～170g is stirred, while going The foam of skim-coat, obtains emulsion, then by emulsion under 300-500Bar homogeneous, homogenisation cycle number of times be 2-4 time, Ran Hou Sterilize at 110～130 DEG C, be cooled to room temperature, nutrition emulsion is obtained, and by filling for nutrition emulsion in sterilized packaging bag.

Hypertension experiment 1

The experiment of this hypertension is carried out with the nutrient powder prepared according to embodiment 1～7 for blank group.

SPF levels Healthy female Wistar rats 130, are randomly divided into normal group 10, hypertension group 120；Male 35 Only.Mouse Oestrous Cycle is determined using vaginal smear method, in emotionally front and Wistar male rats 1：1 mates, and secondary daily inspection is female Mouse introitus and bedding and padding, and make vaginal smear detection, observe cloudy bolt and vaginal smear sperm, it is determined as pregnant 0d.Determine pregnant It is pregnent after starting to raise 14 days, hypertension of pregnancy group is injected intravenously 1.0 μ g of endotoxin per kg body weight, normal group feeds normally to raise Material, once a day, totally 4 days.

After gestation is determined, hypertension group chooses hypertension of pregnancy rat 64 according to order of becoming pregnant, and is divided into 8 groups successively (control group, 1～embodiment of embodiment 7), 8 per group.In after gestation the 10th day, 7 groups of 1～embodiment of embodiment was according to agent Amount 500mg/kg/day gavages, blank group give normal diet, and 2 times a day, raise 2 weeks.Control group chooses 8 according to order of becoming pregnant Only, chow diet nursing is awarded.From the beginning of the 10th day, arteria caudalis is measured using BP-6 animal non-invasive blood pressures measuring system every 2d Pressure, blood pressure result represent (mean arterial pressure=systolic pressure/3+2* diastolic pressure/3) using mean arterial pressure.Measurement data is used SPSS19 software processings, experimental data x ± s represent that (a is represented and compared significant difference, P with normal group<0.05；* represent and right Significant difference, P are compared according to group<0.05；* is represented and is compared significant difference, P with control group<0.01).

Each group rat blood pressure (0d) before 1 formula feeding of table

Table 2 is continuously fed with each formula 14 days, the testing result of rat blood pressure

From Tables 1 and 2, after feeding in 14 days, compared with control group, the mean arterial pressure of 1～7 group of enforcement has (a is represented and is compared significant difference, P with normal group for conspicuousness decline<0.05；* representing, significant difference, P is compared with control group< 0.05；* is represented and is compared significant difference, P with control group<0.01), that is, implementing 1～7 nutrient powder for preparing has drop in various degree The effect of low pregnant mouse blood pressure.

Hypertension experiment 2

The experiment of this hypertension is carried out for nutrient powder prepared by contrast groups and embodiment 1.

A kind of health food for treating the hypertension of pregnancy that contrast groups are prepared using Chinese patent CN103005409A, its are former Material includes chicken, starch, cabbage heart, chrysanthemum tea, jasmine tea, rice and dispensing (cooking wine and salt).

Using the experimental procedure in hypertension experiment 1, SPF level Healthy female Wistar rats, determine that the hypertension of pregnancy is little Mouse, according to becoming pregnant, order chooses hypertension of pregnancy mouse 20, is divided into each group successively, 10 per group, opens within the 10th day after gestation Begin, contrast groups, embodiment 1 are according to dosage 500mg/kg/day gavages.From the beginning of the 10th day, using BP-6 animal non-invasive blood pressures Measuring system measures tail arterial blood pressure, and blood pressure result is represented using mean arterial pressure., using mean value, its result is such as measurement data Described in table 3.

Table 3 is continuously fed with each formula 14 days, the testing result of rat blood pressure

After feeding in 14 days, understand that according to table 3 the mean arterial pressure rate of rise of nutrient powder prepared by embodiment 1 is slightly below The blood pressure lowering effect of nutrient powder prepared by contrast groups 1, i.e. embodiment 1 is slightly better than contrast groups, but contrast groups can not be that gestation is high Blood pressure patient provides comprehensive nutritional support, such as trace element, new resource food etc..

From above-described embodiment, in hypertension of pregnancy tailored version clinical nutrition formula of the present invention, various components are mutual It is engaged, there is provided the suitable energy and various critical nutrients needed for pregnancy-induced hypertension patients, there is provided completely required micro Nutrient content, while by adding the integration of drinking and medicinal herbs composition with blood pressure reduction effect, natural plants compound and new resource food, By above-mentioned experimental data, each component reasonable mixture ratio, shows that hypertension of pregnancy tailored version clinical nutrition formula of the present invention is fed After raising SPF level Wistar hypertension pregnant mouses, blood pressure has conspicuousness to decline, and which can aid in the blood pressure for reducing the hypertension of pregnancy Value, reduces the risk of the hypertension of pregnancy, it is ensured that needed for the growth of fetus and normal development.

Above the specific embodiment of the present invention is described in detail, but which has been only used as example, the present invention has been not intended to limit In particular embodiments described above.To those skilled in the art, any equivalent modifications carried out by the practicality and replace In generation, is also all among scope of the invention.Therefore, the equalization that is made without departing from the spirit and scope of the invention is converted and is repaiied Change, should all cover within the scope of the invention.

Claims

1. a kind of hypertension of pregnancy tailored version clinical nutrition is filled a prescription, it is characterised in that including the component of following parts by weight：25- 35 parts of protein, 8-15 parts fat, 35-45 part carbohydrate, 3-8 part dietary fibers, 0.6-1.2 part macroelements, 0.01- 0.03 part of trace element, 0.005-0.02 part liposoluble vitamins, 0.08-0.2 part water soluble vitamins, 0.5-5 parts meals essence China, 0.5-5 part integration of drinking and medicinal herbs compositions, 0.1-1 part natural plants compounds and 0.1-0.4 part new resource foods；

Wherein, the integration of drinking and medicinal herbs composition in chrysanthemum, the sophora bud, lotus leaf, matrimony vine, oyster, emblic, the root of kudzu vine at least one Kind；

Wherein, the meals elite is selected from cereal, beans, potato class, greengrocery, Homonemeae, nut-seed class, fish and shrimp, poultry At least one in meat, fruits.

2. a kind of hypertension of pregnancy tailored version clinical nutrition according to claim 1 is filled a prescription, it is characterised in that the meals Elite is oatmeal, buckwheat, red bean powder, carrot meal, salmon powder, snow pear powder.

3. a kind of hypertension of pregnancy tailored version clinical nutrition according to claim 1 is filled a prescription, it is characterised in that the new money Source food is selected from first milk basic protein, GABA, chitosan oligosaccharide, eucommia Bark male flower, bamboo-leaves flavones, CPP, oat At least one in beta glucan, yeast beta-dextran, leaf of Moringa, xylo-oligosaccharide.

4. a kind of hypertension of pregnancy tailored version clinical nutrition according to claim 1 is filled a prescription, it is characterised in that described natural Plant compound selected from l-cn, Glucosamine, FOS, lutein, phytosterol, lycopene, resveratrol, At least one in allicin.

5. a kind of hypertension of pregnancy tailored version clinical nutrition according to claim 1 is filled a prescription, it is characterised in that the medicine food Parts by weight with each component in derived components are as follows：Chrysanthemum 0-1 parts, sophora bud 0-1 parts, lotus leaf 0-1 parts, matrimony vine 0-1 parts, oyster 0- 1 part, emblic 0-1 parts, root of kudzu vine 0-1 parts.

6. a kind of hypertension of pregnancy tailored version clinical nutrition according to claim 1 is filled a prescription, it is characterised in that the albumen The good protein weight provided in matter and amino acid accounts for more than the 70% of gross protein weight.

7. a kind of hypertension of pregnancy tailored version clinical nutrition according to claim 1 is filled a prescription, it is characterised in that the fat The ratio of middle n-6 aliphatic acid and n-3 aliphatic acid is 3～4:1.

8. the preparation method that a kind of hypertension of pregnancy tailored version clinical nutrition as claimed in claim 1 is filled a prescription, it is characterised in that The fat makes powder using micro-capsule embedding techniques, and the integration of drinking and medicinal herbs composition is by crushing, sieving and make powder.

9. preparation method according to claim 8, it is characterised in that the mesh number that the integration of drinking and medicinal herbs composition sieves is 60- 80 mesh.