CN106579393A - Special clinical nutrient formula for diabetes and preparation method thereof - Google Patents
Special clinical nutrient formula for diabetes and preparation method thereof Download PDFInfo
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- CN106579393A CN106579393A CN201611208110.2A CN201611208110A CN106579393A CN 106579393 A CN106579393 A CN 106579393A CN 201611208110 A CN201611208110 A CN 201611208110A CN 106579393 A CN106579393 A CN 106579393A
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- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical group [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 235000005772 leucine Nutrition 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 235000021056 liquid food Nutrition 0.000 description 1
- 230000003050 macronutrient Effects 0.000 description 1
- 235000021073 macronutrients Nutrition 0.000 description 1
- 239000001755 magnesium gluconate Substances 0.000 description 1
- 235000015778 magnesium gluconate Nutrition 0.000 description 1
- 229960003035 magnesium gluconate Drugs 0.000 description 1
- IAKLPCRFBAZVRW-XRDLMGPZSA-L magnesium;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate;hydrate Chemical compound O.[Mg+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O IAKLPCRFBAZVRW-XRDLMGPZSA-L 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 239000011683 manganese gluconate Substances 0.000 description 1
- 235000014012 manganese gluconate Nutrition 0.000 description 1
- 229940072543 manganese gluconate Drugs 0.000 description 1
- OXHQNTSSPHKCPB-IYEMJOQQSA-L manganese(2+);(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Mn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OXHQNTSSPHKCPB-IYEMJOQQSA-L 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 235000019713 millet Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 235000020665 omega-6 fatty acid Nutrition 0.000 description 1
- 229940127017 oral antidiabetic Drugs 0.000 description 1
- 239000003538 oral antidiabetic agent Substances 0.000 description 1
- GSSMIHQEWAQUPM-AOLPDKKJSA-N ovalbumin peptide Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CN=CN1 GSSMIHQEWAQUPM-AOLPDKKJSA-N 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000000291 postprandial effect Effects 0.000 description 1
- 239000004224 potassium gluconate Substances 0.000 description 1
- 235000013926 potassium gluconate Nutrition 0.000 description 1
- 229960003189 potassium gluconate Drugs 0.000 description 1
- 229960004839 potassium iodide Drugs 0.000 description 1
- 235000007715 potassium iodide Nutrition 0.000 description 1
- 235000013406 prebiotics Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 239000011684 sodium molybdate Substances 0.000 description 1
- 235000015393 sodium molybdate Nutrition 0.000 description 1
- TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 description 1
- 239000011781 sodium selenite Substances 0.000 description 1
- 235000015921 sodium selenite Nutrition 0.000 description 1
- 229960001471 sodium selenite Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000037351 starvation Effects 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 235000021081 unsaturated fats Nutrition 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 239000008170 walnut oil Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a special clinical nutrient formula for diabetes and a preparation method thereof. The special clinical nutrient formula comprises the following raw materials of 20 to 40 parts of protein, 10 to 20 parts of fat, 25 to 45 parts of carbohydrate, 4 to 10 parts of dietary fiber, 0.6 to 1.2 parts of macroelement, 0.01 to 0.03 part of trace elements, 0.002 to 0.02 part of fat-soluble vitamin, 0.005 to 0.02 part of water-soluble vitamin, 0.1 to 0.6 part of dietary essence, 0.5 to 6 parts of medicinal and edible component, 0.1 to 1 part of natural plant compound and 0.005 to 0.2 part of new resource food, wherein the medicinal and edible compound is selected from at least one of rhizoma polygonati, fermented soybean, folium mori, Chinese yam, hawthorn fruit, liquorice root, platycodon grandiflorum, and folium nelumbinis; the components are prepared into powder in advance, and the fat is treated by a micro-capsule embedding technique, so as to prepare oil powder. The special clinical nutrient formula has the advantages that by screening and proportioning the components, the required energy, key nutrients and necessary trace elements are provided for a diaberic; by adding the component with blood sugar decreasing effect, the blood sugar value of the diaberic is reduced, and the risk of diabetes is decreased.
Description
Technical field
The present invention relates to special medicine purposes formula food field, and in particular to a kind of diabetes tailored version clinical nutrition is matched somebody with somebody
Side and preparation method thereof.
Background technology
Diabetes are one group of metabolic diseases being characterized with hyperglycemia, and long-standing hyperglycemia can cause various groups
Knit, particularly eye, kidney, heart, blood vessel, the chronic lesion of nerve and dysfunction.With our people's growth in the living standard
With the change of dietary structure, the sickness rate of diabetes constantly rises, and wherein type 2 diabetes mellitus account for more than the 90% of all diabetes.
Numerous studies find that pathogenesis and inherited genetic factorss, environmental factorss, insulin resistant and the insulin secretion of type 2 diabetes mellitus lack
Fall into and wait many factors relevant.Epidemiological study shows that obesity, high caloric diet, physical exertion deficiency and increasing age are which is most main
The factors such as the environmental factorss wanted, hypertension, dyslipidemia can also increase risk；Meanwhile, glucose and Abnormal Lipid Metabolism
It is the major reason for causing insulin resistant and defect of insulin secretion.For this purpose, by the generation of nutritional intervention diabetes, development
Become the important means of alimentary field.
Before nineteen twenty-one, " complete starvation " is the basic skills of diabetes nutrition treatment, but can cause hypoglycemia, ketone
Disease and protein calories malnutrition.Thereafter, in 80 years, the energy supply ratio of saccharide (carbohydrate) and fat experienced 3 times
Big change:(1) the 1921-1950 ages, adopt " simple staple food control methods ", limit saccharide intake, fatty energy supply ratio rises to
70%, but because satisfied fatty acid intake is too high, the danger for suffering from cardiovascular diseasess increases therewith；(2) at the beginning of 1950-1990, progressively
Saccharide energy supply ratio is improved to 60-65%, fat is down to 25%-30%, but unresolved satisfied fatty acid (SFA) takes in too high asking
The suitable proportion of topic, monounsaturated fatty acid and polyunsaturated fatty acid is not also clear and definite.Meanwhile, because noticing high sugar intake to luring
Leading plasma triglyceride and increasing and cause hyperglycemia to have potential negative effect, lack enough evidences in addition, improve
Saccharide energy supply ratio falls under suspicion to improve blood glucose and improve the theory of insulin sensitivity.(3) 1994-2000, U.S.'s glycosuria
Disease association (ADA) and NIH propose new diabetes nutrition therapeutic goal and nutrient allowance standard.
Emphasize, by changing lifestyles, to absorb suitable heat, adjust the type of Macronutrient and constitute ratio, appropriate complementary diets
The means such as fiber, reach the purpose of control blood glucose, blood fat and blood pressure.
ADA proposed the main target of diabetes nutrition treatment in 2000, i.e.,：(1) realize heat and Nutrition intake,
Temper competence and the balance of Drug therapy (including insulin or/and oral antidiabetic drug) three, thus reach and maintain just to be close to
Normal blood sugar level；(2) reach and maintain preferable blood fat and blood pressure；(3) by adjusting energy intake and composition, reach
And maintain ideal body weight or reasonable body weight；(4) prevent and treat all kinds of acute and chronic complication；(5) it is dry by rational nutrition
In advance, improve general health, and improve the quality of living.
Above-mentioned target is applied equally to China's diabeticss.But taking in appropriate heat, rational magnanimity nutrition
Outside plain type and composition ratio, appropriate dietary fiber, it is necessary to which trace element is also the requisite nutritional labeling of human body；China some
Traditional medicinal and edible plant, also has helpful to diabeticss, has effect of lowering blood sugar.
Have much for the product of diabeticss on the market at present, but the nutrient formulation of suitable diabeticss has
Open defect.Such as：External product (Abbott Laboratories, Fei Senyoushika ratios) is only capable of providing effective nutritional support, without integration of edible and medicinal herbs or
New resources composition, itself is without function of blood sugar reduction；Although Some Domestic product with the addition of part and has the medicine food of function of blood sugar reduction same
Source or new resources composition, but the support of its nutrient, especially essential trace element is insufficient.
Chinese patent CN1515186A discloses a kind of fully nutrient liquid food suitable for diabetes patient and its manufacture
Method, which includes carbohydrate, fat, proteins,vitamins,and minerals, and specifically defines the composition of carbohydrate
It is 70 ± 10% and the Soy-based Protein in the food starch and protein of α-amylase mild hydrolysis containing amylose amount
Matter accounts for the 50-100% of protein gross mass, but itself and be not added with integration of edible and medicinal herbs composition, natural plants compound and new resources food
The components such as product, which can not comprehensively meet the daily nutrition demand of diabeticss, can not effectively reduce diabeticss
Blood glucose value, there is certain potential safety hazard in this.
The content of the invention
It is an object of the invention to overcome defect of the prior art, there is provided a kind of diabetes tailored version clinical nutrition formula
And preparation method thereof, diabetes tailored version clinical nutrition formula prepared by the present invention provides comprehensive nutrition for diabeticss
Hold, which contains suitable energy and various critical nutrients needed for diabeticss, there is provided completely required micronutrient into
Point, by integration of edible and medicinal herbs composition of the addition with effect of lowering blood sugar, natural plants compound and new resource food, auxiliary reduces sugar
The blood glucose value of urine patient, reduces the risk of diabetes.
For achieving the above object, the present invention is adopted the following technical scheme that：
On the one hand, the present invention provides a kind of diabetes tailored version clinical nutrition formula, including the component of following parts by weight：
20-40 part protein, 10-20 parts fat, 25-45 part carbohydrates, 4-10 part dietary fibers, 0.6-1.2 part macroelements,
0.01-0.03 part trace element, 0.002-0.02 part fatsoluble vitamiies, 0.005-0.02 part water soluble vitamins, 0.1-0.6
Part meals elite, 0.5-6 part integration of edible and medicinal herbs compositions, 0.1-1 part natural plants compounds and 0.005-0.2 parts new resources food
Product.
In order to further optimize above-mentioned technical proposal, the technical measures taken by the present invention also include：
Preferably, the protein is selected from lactalbumin powder, soybean protein isolate, whole milk powder, dried whole-egg, newborn ferrum egg
In vain, at least one in cattle colostrumss, aminoacid, protein peptide；
Wherein, the aminoacid is selected from 1B-L-Glutamic Acid, mono- glutamic acid of L, mono- arginine of L, L-Tryptophan, L mono-
At least one in glutamine, taurine, mono- L-Valine of L, L-Isoleucine, mono- leucines of L；The protein peptide is selected from Semen sojae atricolor
In oligopeptide, wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide powder, laughable peptide, amino peptide, ovalbumin peptide at least
It is a kind of.
Preferably, the fat includes satisfied fatty acid, polyunsaturated fatty acid, monounsaturated fatty acid, OPO structures
At least one in fat, DHA, EPA, ARA, phospholipid, more specifically it is described fat include safflower oil, walnut oil, Oleum Arachidis hypogaeae semen,
Soybean oil, Ah's glycerol, olive oil, Oleum Camelliae, oil and fat of sacha inchi, olive oil, Oleum Cocois, perilla oil, bathypelagic fish oil, cupu oil, Petiolus Trachycarpi
Oil, Adeps Bovis seu Bubali, butter, Adeps Sus domestica, Medium-chain Triglycerides, lecithin.
Preferably, during the carbohydrate includes Fructose, crystal sugar, Lactose, maltodextrin, tapioca, resistant starch
At least two.
Preferably, the dietary fiber comprising inulin, Rhizoma amorphophalli powder, oligomeric galactose, oligofructose, oligomeric isomaltose,
At least one in soybean polysaccharide, cyclodextrin, resistant dextrin, soybean fiber.
Preferably, the macroelement is selected from calcium citrate, L-calcium lactate, calcium hydrogen phosphate, potassium gluconate, sodium citrate
With at least one in magnesium gluconate.
Preferably, the trace element is selected from Ferrous gluconate, potassium iodide, zinc gluconate, sodium selenite, glucose
At least one in sour copper, chromic sulfate, manganese gluconate and sodium molybdate.
Preferably, the fatsoluble vitamin is selected from vitamin A, beta-carotene, Vitamin D3, Vitamin E, vitamin
At least one in K1.
Preferably, the water soluble vitamins are selected from vitamin B1, vitamin B2, vitamin B6, Vitamin B12, dimension life
At least one in plain C, pantothenic acid, Folic Acid, nicotinic acid, choline, inositol, biotin.
Preferably, the meals elite is selected from frumentum, beans, potato class, greengrocery, Homonemeae, nut-seed class, fish and shrimp
At least one in class, poultry meat, fruits；Wherein described frumentum mainly by rice meal, millet powder, black rice flour, coixlacrymajobi powder,
One kind in Semen Maydis powder, wheat germ powder, oatmeal, Fagopyrum esculentum Moench powder or at least two compositions, the beans is mainly by peameal, green
One kind or at least two compositions in Semen Glycines powder, black bean powder, red bean powder, Semen sojae atricolor powder, the potato class are mainly made up of common yam rhizome powder, described
Vegetable powder is mainly by one kind in Radix Dauci Sativae powder, white radish powder, Fructus Cucurbitae moschatae powder, Herba Spinaciae powder, tomato meal, broccoli powder, Fructus Momordicae charantiae powder or several
Composition is planted, mainly by one or more in mushroom powder and Tremella powder, the nut-seed class is mainly Semen Nelumbinis to the Homonemeae
Powder, the fish and shrimp are mainly made up of one or more in salmon fish powder and cod meal, the poultry meat mainly by
In Carnis Gallus domesticus powder, beef powder one or more composition, the fruits mainly by red date powder, Arillus Longan powder, apple powder, cherry powder,
One or more compositions in Citrus powder, pear powder；The meals elite is more preferably Fructus Momordicae charantiae powder.
Preferably, the integration of edible and medicinal herbs composition is selected from Rhizoma Polygonati, Semen Sojae Preparatum, Folium Mori, Rhizoma Dioscoreae, Fructus Crataegi, Radix Glycyrrhizae, Radix Platycodoniss, Folium Nelumbinis
In at least one.
Preferably, the natural plants compound is selected from L-carnitine, glucosamine, oligofructose, phylloxanthin, plant
At least one in sterol, lycopene, resveratrol, garlicin；The natural plants compound is more preferably L-carnitine.
Preferably, the new resource food is selected from first milk basic protein, γ-aminobutyric acid, oligochitosan, eucommia Bark male flower, bamboo
At least one in leaf flavone, phosphopeptide caseinate, avenabeta glucosan, yeast beta-dextran, leaf of Moringa, oligomeric xylose；Institute
State new resource food and be more preferably avenabeta glucosan.
Preferably, in the integration of edible and medicinal herbs composition, the parts by weight of each component are as follows：Rhizoma Polygonati 0-1 parts, Semen Sojae Preparatum 0-1 parts,
Folium Mori 0-1 parts, Rhizoma Dioscoreae 0-1 parts, Fructus Crataegi 0-1 parts, Radix Glycyrrhizae 0-1 parts, Radix Platycodoniss 0-1 parts, Folium Nelumbinis 0-1 parts.
Preferably, the high quality protein weight provided in the protein and aminoacid accounts for the 70% of gross protein weight
More than.
Preferably, in the fat, the ratio of n-6 fatty acids and n-3 fatty acids is 3～4:1.
Preferably, the monounsaturated fatty acid ratio of the fat is higher than satisfied fatty acid ratio.
On the other hand, the present invention relates to it is a kind of by above-mentioned diabetes tailored version clinical nutrition formula prepare product, including
Nutritive powder, nutrition emulsion, capsule, tablet, pill, oral liquid etc..
Finally, the present invention also provides a kind of nutritive powder that is prepared into by described diabetes tailored version clinical nutrition formula
Method, which comprises the steps：By the protein of predetermined weight number, fat, carbohydrate, dietary fiber, macroelement,
Trace element, fatsoluble vitamin, water soluble vitamins, meals elite, integration of edible and medicinal herbs composition, natural plants compound and new
Resource food is prepared into the powdery that particle diameter is 100～300 μm respectively, by the powdery mix homogeneously, obtains diabetes tailored version
Complete nourishing powder, after sterilization processing, fill is in packaging bag or is placed directly within pail pack；Wherein, the fat is using micro-
Capsule embedding techniqueses make powder, and the integration of edible and medicinal herbs composition makes powder by crushing, crossing 60～80 mesh sieves.
The present invention also provides a kind of side for being prepared into nutrition emulsion by described diabetes tailored version clinical nutrition formula
Method, which comprises the steps：
Step one, by the protein of predetermined weight number, fat, carbohydrate, dietary fiber, macroelement, micro
Element, fatsoluble vitamin, water soluble vitamins, meals elite, integration of edible and medicinal herbs composition, natural plants compound and new resources
Food is prepared into the powdery that particle diameter is 100～300 μm respectively；Wherein, the fat makes powder using microcapsule embedding techniqueses,
The integration of edible and medicinal herbs composition makes powder by crushing, crossing 60-80 mesh sieves；
Step 2, protein powder prepared by step one is dissolved in in pure water abundant aquation, obtains protein aqueous solution
In, then it is prepared by step one carbohydrate powder, macroelement powder, trace element powder, water soluble vitamins powder
It is dissolved in protein aqueous solution, obtains aqueous phase solution；
Step 3, by Vegetable oil lipoprotein and fatsoluble vitamin powder, meals elite powder, integration of edible and medicinal herbs component powders,
Natural plants compound powder sequentially adds the aqueous phase solution of gained in step 2, and carries out strong agitation, addition emulsifying agent and
Thickening agent, obtains concentrated emulsions；
Step 4, in the concentrated emulsions described in step 3 add scheduled volume water and stir, while removing skim-coat
Foam, obtains Emulsion, then by Emulsion homogenizing, high temperature sterilize, cooling under high pressure, nutrition emulsion is obtained, and fill is in packaging
In bag.
Preferably, the specific implementation step of the microcapsule embedding techniqueses is as follows：Fat, emulsifying agent, wall material are mixed with water
Dissolving prepares emulsion；After by the stirring mixing of above-mentioned emulsion, emulsifying homogeneous process is carried out, is then spray-dried, sieved
Powdered oil is prepared, powdered oil is compared with conventional grease, its dispersibility, water solublity, emulsibility, non-oxidizability have and carry greatly very much
It is high；
Wherein, the emulsifying agent is selected from fatty acid glyceride (glyceride), methyl glycol fatty acid ester (propylene glycol ester), Pyrusussuriensiss
One or more in polysaccharide fatty acid ester (sorbitan acid), sucrose fatty acid ester (sucrose ester), lecithin；The wall material choosing
From sodium carboxymethyl cellulose, gelatin, carrageenan, xanthan gum, arabic gum, guar gum, maltodextrin, lipoprotein, corn syrup
In one or more.
Compared with prior art, the invention has the advantages that：
(1) the carbohydrate main source that the present invention is adopted is Fructose, resistant starch etc., resistant starch and dietary fiber
Slow release starch class material is, the position that each slow release starch class material is digested and assimilated in intestinal is different with the time, it is relatively common to seek
Foster agent absorbs more slow, and post-prandial glycemia is relatively more steady；Add and adjust monounsaturated fatty acid and how unsaturated fat simultaneously
The content of fat acid, brings up to 40% the energy supply ratio of fat.Unsaturated fatty acid has reduces blood glucose and cholesterol, adjusts blood fat
Level, prevents arteriosclerosis, reduces the effect such as insulin resistant.
(2) add Fructus Momordicae charantiae powder in the present invention as meals elite, Fructus Momordicae charantiae is described as " glucokinin ", and nature and flavor sweetness and bitterness is trembled with fear
It is cool, can heat clearing away, relieving restlessness, quench the thirst, the bitter gourd polypeptide class material contained by Fructus Momordicae charantiae has, can prevent and
Improve the complication of diabetes, with regulation blood fat, the effect of enhance immunity.
(3) present invention addition simultaneously has the integration of edible and medicinal herbs composition of effect of lowering blood sugar, between each component, scientific compatibility, and association
Same-action, can play the hypoglycemic effect of drop well.
(4) using avenabeta glucosan as new resource food, avenabeta glucosan has enhance immunity, drop to the present invention
Low cholesterol, blood sugar lowering, anticancer, the effect for improving intestinal state.
(5) present invention prepares powdered oil using microcapsule embedding techniqueses so that powdered oil has preferable mobility, easily
In mixing homogeneously with other powdered components；And using after microcapsule embedding techniqueses, oils and fatss are embedded in wall material, so as to avoid with
The contact of air to strengthen non-oxidizability, so as to the maximum effect of health oils and fatss can be played.
(6) raw material of diabetes tailored version clinical nutrition formula of the present invention in preparation process it is previously prepared into
100～300 μm of powder, this is caused when finished product is prepared, and each nutrition composition being capable of mix homogeneously, it is ensured that each in unit volume
The content of nutrition composition is identical, while when liquid type preparation is prepared, each nutrition composition can be fully dispersed and be completely dissolved to molten
In agent, in preventing liquid, there is solid precipitation, effect of finished product product has been effectively ensured.
Specific embodiment
The present invention provides a kind of for the clinical with the diabetes tailored version enteral for suppressing blood glucose rise of diabeticss
Nutrient formulation, including the component of following parts by weight：20-40 part protein, 10-20 parts fat, 25-45 part carbohydrates,
4-10 part dietary fibers, 0.6-1.2 part macroelements, 0.01-0.03 part trace element, the fat-soluble dimension life of 0.002-0.02 parts
Element, 0.005-0.02 part water soluble vitamins, 0.1-0.6 part meals elite, 0.5-6 part integration of edible and medicinal herbs compositions, 0.1-1 parts are natural
Plant compound and 0.005-0.2 part new resource foods.
With reference to embodiment, the specific embodiment of the present invention is further described.Following examples are only used for more
Plus technical scheme is clearly demonstrated, and can not be limited the scope of the invention with this.
Embodiment 1
Diabetes tailored version clinical nutrition formula of the present invention include lactalbumin powder 7g, soybean protein isolate 7g,
Whole milk powder 18g, dried whole-egg 0.5g, cattle colostrumss 0.15g, taurine 0.11g, soybean oligopeptide 0.1g, ocean fish oligopeptide powder
0.1g；Olive oil 9.6g, soybean oil 4.9g, Oleum Cocois 0.29g, perilla oil 1g, Medium-chain Triglycerides 0.5g；Maltodextrin 11g,
Tapioca 8.3g, resistant starch 14.3g；Dietary fiber 8g；Calcium 0.4g, phosphorus 0.25g, potassium 0.08g, sodium in macroelement
0.02g, magnesium 0.15g；Ferrum 0.011g, iodine 0.00014g, zinc 0.007g in trace element；Vitamin in fatsoluble vitamin
A0.0006g, beta-carotene 0.000057g, vitamin D30.000001g, Vitamin E 0.009g；In water soluble vitamins
Vitamin B10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B120.000002g, vitamin C
0.117g, pantothenic acid 0.003g, Folic Acid 0.000165g, nicotinic acid 0.0165g；Fructus Momordicae charantiae powder 0.5g；Rhizoma Polygonati in integration of edible and medicinal herbs composition
0.4g, Semen Sojae Preparatum 0.6g, Folium Mori 0.6g, Rhizoma Dioscoreae 0.3g, Fructus Crataegi 0.5g, Radix Glycyrrhizae 0.6g, Radix Platycodoniss 0.5g, Folium Nelumbinis 0.5g；Natural plant
L-carnitine 0.636g in compounds；Avenabeta glucosan 0.02g in new resource food.
Embodiment 2
Diabetes tailored version clinical nutrition formula of the present invention include lactalbumin powder 7g, soybean protein isolate 6g,
Whole milk powder 15g, dried whole-egg 2g, cattle colostrumss 0.5g, taurine 0.11g, soybean oligopeptide 0.1g, ocean fish oligopeptide powder
0.1g；Olive oil 11.6g, soybean oil 2.9g, Oleum Cocois 0.29g, perilla oil 0.29g, Medium-chain Triglycerides 0.29g；Fructus Hordei Germinatus are pasted
Smart 14.9g, tapioca 9.3g, resistant starch 12.3g；Dietary fiber 7.6g；Calcium 0.4g, phosphorus 0.25g, potassium in macroelement
0.08g, sodium 0.02g, magnesium 0.15g；Ferrum 0.011g, iodine 0.00014g, zinc 0.007g in trace element；Tie up in fatsoluble vitamin
Raw element A0.0006g, beta-carotene 0.000057g, vitamin D30.000001g, Vitamin E 0.009g；Water soluble vitamin is given birth to
Vitamin B in element10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B120.000002g, vitamin C
0.117g, pantothenic acid 0.003g, Folic Acid 0.000165g, nicotinic acid 0.0165g；Fructus Momordicae charantiae powder 0.2g；Rhizoma Polygonati in integration of edible and medicinal herbs composition
0.4g, Semen Sojae Preparatum 0.5g, Folium Mori 0.5g, Rhizoma Dioscoreae 0.4g, Fructus Crataegi 0.4g, Radix Glycyrrhizae 0.5g, Radix Platycodoniss 0.4g, Folium Nelumbinis 0.4g；Natural plant
L-carnitine 0.7g in compounds；Avenabeta glucosan 0.05g in new resource food.
Embodiment 3
Diabetes tailored version clinical nutrition formula of the present invention includes lactalbumin powder 5.5g, soybean protein isolate
7.2g, whole milk powder 18.2g, dried whole-egg 0.18g, cattle colostrumss 0.15g, taurine 0.11g, soybean oligopeptide 0.1g, marine fish
Oligomeric Gly-His-Lys 0.1g；Olive oil 11.6g, soybean oil 2.9g, Oleum Cocois 0.29g, perilla oil 0.29g, Medium-chain Triglycerides
0.29g；Maltodextrin 14.9g, tapioca 7.3g, resistant starch 12.3g；Dietary fiber 7.6g；Calcium 0.4g in macroelement,
Phosphorus 0.25g, potassium 0.08g, sodium 0.02g, magnesium 0.15g；Ferrum 0.011g, iodine 0.00014g, zinc 0.007g in trace element；It is fat-soluble
Vitamin A 0.0006g, beta-carotene 0.000057g, vitamin D in vitamin30.000001g, Vitamin E 0.009g；
Vitamin B in water soluble vitamins10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B12
0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, Folic Acid 0.000165g, nicotinic acid 0.0165g；Fructus Momordicae charantiae powder 0.2g；Medicine is eaten
With Rhizoma Polygonati 0.167g, Semen Sojae Preparatum 0.167g, Folium Mori 0.167g, Rhizoma Dioscoreae 0.167g, Fructus Crataegi 0.167g, Radix Glycyrrhizae in derived components
0.167g, Radix Platycodoniss 0.167g, Folium Nelumbinis 0.167g；L-carnitine 0.636g in natural plants compound；Herba bromi japonici in new resource food
Beta glucan 0.02g.
Embodiment 4
Diabetes tailored version clinical nutrition formula of the present invention includes lactalbumin powder 5.5g, soybean protein isolate
7.2g, whole milk powder 18.2g, dried whole-egg 0.18g, cattle colostrumss 0.15g, taurine 0.11g, soybean oligopeptide 0.1g, marine fish
Oligomeric Gly-His-Lys 0.1g；Olive oil 11.6g, soybean oil 2.9g, Oleum Cocois 0.29g, perilla oil 0.29g, Medium-chain Triglycerides
0.29g；Maltodextrin 14.9g, tapioca 7.3g, resistant starch 12.3g；Dietary fiber 7.6g；Calcium 0.4g in macroelement,
Phosphorus 0.25g, potassium 0.08g, sodium 0.02g, magnesium 0.15g；Ferrum 0.011g, iodine 0.00014g, zinc 0.007g in trace element；It is fat-soluble
Vitamin A 0.0006g, beta-carotene 0.000057g, vitamin D in vitamin30.000001g, Vitamin E 0.009g；
Vitamin B in water soluble vitamins10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B12
0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, Folic Acid 0.000165g, nicotinic acid 0.0165g；Fructus Momordicae charantiae powder 0.2g；Medicine is eaten
With Rhizoma Polygonati 0.1g, Semen Sojae Preparatum 0.1g, Folium Mori 0.1g, Rhizoma Dioscoreae 0.1g, Fructus Crataegi 0.1g, Radix Glycyrrhizae 0.1g, Radix Platycodoniss 0.1g, lotus in derived components
Leaf 0.1g；L-carnitine 0.636g in natural plants compound；Avenabeta glucosan 0.02g in new resource food.
Embodiment 5
Diabetes tailored version clinical nutrition formula of the present invention includes lactalbumin powder 5.5g, soybean protein isolate
7.2g, whole milk powder 18.2g, dried whole-egg 0.18g, cattle colostrumss 0.15g, taurine 0.11g, soybean oligopeptide 0.1g, marine fish
Oligomeric Gly-His-Lys 0.1g；Olive oil 11.6g, soybean oil 2.9g, Oleum Cocois 0.29g, perilla oil 0.29g, Medium-chain Triglycerides
0.29g；Maltodextrin 14.9g, tapioca 7.4g, resistant starch 12.3g；Dietary fiber 7.6g；Calcium 0.4g in macroelement,
Phosphorus 0.25g, potassium 0.08g, sodium 0.02g, magnesium 0.15g；Ferrum 0.011g, iodine 0.00014g, zinc 0.007g in trace element；It is fat-soluble
Vitamin A 0.0006g, beta-carotene 0.000057g, vitamin D in vitamin30.000001g, Vitamin E 0.009g；
Vitamin B in water soluble vitamins10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B12
0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, Folic Acid 0.000165g, nicotinic acid 0.0165g；In integration of edible and medicinal herbs composition
Rhizoma Polygonati 0.1g, Semen Sojae Preparatum 0.1g, Folium Mori 0.1g, Rhizoma Dioscoreae 0.1g, Fructus Crataegi 0.1g, Radix Glycyrrhizae 0.1g, Radix Platycodoniss 0.1g, Folium Nelumbinis 0.1g；My god
L-carnitine 0.636g in right plant compound；Avenabeta glucosan 0.02g in new resource food.
Embodiment 6
Diabetes tailored version clinical nutrition formula of the present invention includes lactalbumin powder 5.5g, soybean protein isolate
7.2g, whole milk powder 18.2g, dried whole-egg 0.18g, cattle colostrumss 0.15g, taurine 0.11g, soybean oligopeptide 0.1g, marine fish
Oligomeric Gly-His-Lys 0.1g；Olive oil 11.6g, soybean oil 2.9g, Oleum Cocois 0.29g, perilla oil 0.29g, Medium-chain Triglycerides
0.29g；Maltodextrin 14.9g, tapioca 8.1g, resistant starch 12.3g；Dietary fiber 7.6g；Calcium 0.4g in macroelement,
Phosphorus 0.25g, potassium 0.08g, sodium 0.02g, magnesium 0.15g；Ferrum 0.011g, iodine 0.00014g, zinc 0.007g in trace element；It is fat-soluble
Vitamin A 0.0006g, beta-carotene 0.000057g, vitamin D in vitamin30.000001g, Vitamin E 0.009g；
Vitamin B in water soluble vitamins10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B12
0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, Folic Acid 0.000165g, nicotinic acid 0.0165g；Fructus Momordicae charantiae powder 0.2g；It is natural
L-carnitine 0.636g in plant compound；Avenabeta glucosan 0.02g in new resource food.
Embodiment 7
Diabetes tailored version clinical nutrition formula of the present invention includes lactalbumin powder 5.5g, soybean protein isolate
7.2g, whole milk powder 18.2g, dried whole-egg 0.18g, cattle colostrumss 0.15g, taurine 0.11g, soybean oligopeptide 0.1g, marine fish
Oligomeric Gly-His-Lys 0.1g；Olive oil 11.6g, soybean oil 2.9g, Oleum Cocois 0.29g, perilla oil 0.29g, Medium-chain Triglycerides
0.29g；Maltodextrin 14.9g, tapioca 8.3g, resistant starch 12.3g；Dietary fiber 7.6g；Calcium 0.4g in macroelement,
Phosphorus 0.25g, potassium 0.08g, sodium 0.02g, magnesium 0.15g；Ferrum 0.011g, iodine 0.00014g, zinc 0.007g in trace element；It is fat-soluble
Vitamin A 0.0006g, beta-carotene 0.000057g, vitamin D in vitamin30.000001g, Vitamin E 0.009g；
Vitamin B in water soluble vitamins10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B12
0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, Folic Acid 0.000165g, nicotinic acid 0.0165g；Natural plants compound
Middle L-carnitine 0.636g；Avenabeta glucosan 0.02g in new resource food.
Embodiment 8
The preparation method of the nutritive powder of the diabetes tailored version clinical nutrition formula containing embodiment 1- embodiment 7 is as follows：
1) prepare powdered oil：By the fat of predetermined weight with sucrose ester, monoglyceride, maltodextrin, water at 70 DEG C or so
Carry out mixed dissolution and prepare emulsion, the wherein consumption of sucrose ester and monoglyceride for emulsion weight 2.5%～5%, water
10～15 times for fat weight of consumption, maltodextrin consumption for emulsion weight 8%～20%；Above-mentioned emulsion is stirred
After 2～5min of mixing, 2 emulsifying homogeneous being carried out under high pressure and being processed, the emulsifying homogeneous time is 12～18min；Then sprayed
Mist is dried, and prepares powdered oil with 60～80 mesh sieves point；
2) integration of edible and medicinal herbs component powders are prepared：By the integration of edible and medicinal herbs composition of predetermined weight be put into pulverizer carry out crushing, mistake
60～80 mesh sieves make integration of edible and medicinal herbs component powders；
3) by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, the life of fat-soluble dimension
Element, water soluble vitamins, meals elite, natural plants compound and new resource food are prepared into particle diameter respectively for 100～300
μm powdery；
4) by step 1)～step 3) obtained by powder mix homogeneously, to obtain diabetes tailored version complete nourishing powder,
After sterilization processing, fill is in sterilized packaging bag or is placed directly within sterilized pail pack.
Aforesaid operations step is both needed to carry out under the protection of noble gases, such as nitrogen protection, to prevent that powder is quick-fried
Fried danger.
Embodiment 9
The preparation method of the nutrition emulsion of the diabetes tailored version clinical nutrition formula containing embodiment 1- embodiment 7 is such as
Under：
1) prepare powdered oil：By the fat of predetermined weight with sucrose ester, monoglyceride, maltodextrin, water at 70 DEG C or so
Carry out mixed dissolution and prepare emulsion, the wherein consumption of sucrose ester and monoglyceride for emulsion weight 2.5%～5%, water
10～15 times for fat weight of consumption, maltodextrin consumption for emulsion weight 8%～20%；Above-mentioned emulsion is stirred
After 2～5min of mixing, 2 emulsifying homogeneous being carried out under high pressure and being processed, the emulsifying homogeneous time is 12～18min；Then sprayed
Mist is dried, and prepares powdered oil with 60～80 mesh sieves point；
2) integration of edible and medicinal herbs component powders are prepared：By the integration of edible and medicinal herbs composition of predetermined weight be put into pulverizer carry out crushing, mistake
60～80 mesh sieves make integration of edible and medicinal herbs component powders；
3) by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, the life of fat-soluble dimension
Element, water soluble vitamins, meals elite, natural plants compound and new resource food are prepared into particle diameter respectively for 100～300
μm powdery；
4) by step 3) in protein powder be dissolved in temperature be 20～25 DEG C, abundant water in the pure water of 300～375g
Change 3～15h, obtain in protein aqueous solution, then by step 3) in carbohydrate powder, macroelement powder, micro unit
Plain powder, water soluble vitamins powder are dissolved in protein aqueous solution, the aqueous phase solution that gentle agitation is uniformly mixed；
5) by step 1) in microcapsule embedding treatment after fat powder, step 2) in prepare fatsoluble vitamin powder
End, meals elite powder, integration of edible and medicinal herbs component powders, natural plants compound powder sequentially add the water phase of gained in step 4
Solution, and strong agitation is carried out, add emulsifying agent and thickening agent, the concentrated emulsions being uniformly mixed；
6) in step 5) in add 20～25 DEG C in the concentrated emulsions that prepare, the pure water of 125～200g stir, while
Remove the foam of skim-coat, obtain Emulsion, then by Emulsion under 300～500Bar homogenizing, homogenisation cycle number of times be 2～4 times, so
Sterilize at 110～130 DEG C afterwards, be cooled to room temperature, nutrition emulsion is obtained, and by nutrition emulsion fill in sterilized packaging bag
In.
Aforesaid operations step is both needed to carry out under the protection of noble gases, such as nitrogen protection, to prevent that powder is quick-fried
Fried danger.
Blood sugar lowering experiment 1
The experiment of this blood sugar lowering is carried out with the nutritive powder prepared according to embodiment 1～7 for blank group.
SPF levels C57BL/KsJ (db/db) 100, measure its basal plasma glucose daily.After raising 7 days, 64 blood are filtered out
The diabetic mice of sugared value stabilization.According to blood sugar level, it is divided into 8 groups (8 per group), makes for blank group and embodiment 1～7
Standby nutritive powder.
Blank group gives normal diet, and nutritive powder prepared by embodiment 1～7 is raised according to dosage 1000mg/kg/day gavages
Support 2 weeks, use blood-sugar detecting instrument Fundamentals of Measurement blood glucose daily.Measurement data use SPSS19 software processes, experimental data x ±
S represents (*, P<0.05；**,P<0.01), its result is as shown in table 1.
The 1 continuous feed db/db diabetic mices blood glucose test results of 2 weeks of table
As seen from the above table, after 14 days feed, compared with blank group, the db/db mouse blood sugars of 1～7 group of embodiment are all
There is significance to decline (*, P<0.05；*, P<0.01) nutritive powder that, i.e., prepared by embodiment 1～7 has reduces blood to some extent
The effect of sugar.
Blood sugar lowering experiment 2
The experiment of this blood sugar lowering is carried out for the nutritive powder that matched group 1, matched group 2 are prepared with embodiment 1.
Matched group 1 using Chinese patent CN105029410A prepare the full nutritional breast dosage form formula food of diabetes, its by
Nutrient matrix, composite mineral matter, compound vitamin and integration of edible and medicinal herbs Chinese herbal medicine extract composition, the nutrient matrix include albumen
Matter, carbohydrate and fat.
The diabetes full nutrition formula food that matched group 2 is prepared using Chinese patent CN104187708A, which is carried with Chinese medicine
Thing elite, probiotic bacteria, small peptide, prebioticses are taken for primary raw material, with aminoacid, water soluble dietary fiber, compound vitamin, compound
Mineral is adjuvant.
SPF levels C57BL/KsJ (db/db) 60 are chosen, its basal plasma glucose is measured daily.After raising 7 days, 30 are filtered out
The diabetic mice of blood glucose value stabilization.According to blood sugar level, it is divided into 3 groups (10 per group), for control 1, control 2 and embodiment
1 nutritive powder for preparing.
Nutritive powder prepared by matched group 1, matched group 2 and embodiment 1 is raised according to dosage 1000mg/kg/day gavages
Support 2 weeks, use blood-sugar detecting instrument Fundamentals of Measurement blood glucose daily.Measurement data uses meansigma methodss, and its result is as described in Table 2.
The 2 continuous feed db/db diabetic mices blood glucose test results of 2 weeks of table
As seen from the above table, after 14 days feed, it is right that the blood sugar decreasing effect of the nutritive powder prepared by embodiment 1 is substantially better than
According to group 1 and matched group 2.
From above-described embodiment, in diabetes tailored version clinical nutrition formula of the present invention, various components mutually match
Close, there is provided the suitable energy and various critical nutrients needed for diabeticss, there is provided completely required micro-nutrient composition,
Simultaneously by integration of edible and medicinal herbs composition of the addition with effect of lowering blood sugar, natural plants compound and new resource food, each component is matched somebody with somebody
Than reasonable, and it is easy to digest and assimilate, shows that diabetes tailored version clinical nutrition of the present invention is matched somebody with somebody by above-mentioned experimental data
Square feed db/db mouse blood sugars have significance to decline, and which can aid in the blood glucose value for reducing diabeticss, reduce diabetes
Risk.
Above the specific embodiment of the present invention is described in detail, but which has been only used as example, the present invention has been not intended to limit
In particular embodiments described above.To those skilled in the art, any equivalent modifications carried out by the practicality and replace
In generation, is also all among scope of the invention.Therefore, the equalization made without departing from the spirit and scope of the invention is converted and is repaiied
Change, should all cover within the scope of the invention.
Claims (8)
1. a kind of diabetes tailored version clinical nutrition formula, it is characterised in that including the component of following parts by weight：20-40 parts
Protein, 10-20 parts fat, 25-45 part carbohydrates, 4-10 part dietary fibers, 0.6-1.2 part macroelements, 0.01-
0.03 portion of trace element, 0.002-0.02 part fatsoluble vitamiies, 0.005-0.02 part water soluble vitamins, 0.1-0.6 part meals
Food elite, 0.5-6 part integration of edible and medicinal herbs compositions, 0.1-1 part natural plants compounds and 0.005-0.2 part new resource foods；
Wherein, the meals elite is selected from frumentum, beans, potato class, greengrocery, Homonemeae, nut-seed class, fish and shrimp, poultry
At least one in meat, fruits；
Wherein, the integration of edible and medicinal herbs composition selected from Rhizoma Polygonati, Semen Sojae Preparatum, Folium Mori, Rhizoma Dioscoreae, Fructus Crataegi, Radix Glycyrrhizae, Radix Platycodoniss, in Folium Nelumbinis extremely
Few one kind.
2. a kind of diabetes tailored version clinical nutrition formula according to claim 1, it is characterised in that the new resources food
Product are selected from first milk basic protein, γ-aminobutyric acid, oligochitosan, eucommia Bark male flower, Folium Bambosae flavone, phosphopeptide caseinate, Herba bromi japonici β-Portugal
At least one in polysaccharide, yeast beta-dextran, leaf of Moringa, oligomeric xylose.
3. a kind of diabetes tailored version clinical nutrition formula according to claim 1, it is characterised in that the natural plants
Compound is selected from L-carnitine, glucosamine, oligofructose, phylloxanthin, plant sterol, lycopene, resveratrol, Bulbus Allii
At least one in element.
4. a kind of diabetes tailored version clinical nutrition formula according to claim 1, it is characterised in that the protein and
The high quality protein weight provided in aminoacid accounts for more than the 70% of gross protein weight.
5. a kind of diabetes tailored version clinical nutrition formula according to claim 1, it is characterised in that n- in the fat
The ratio of 6 fatty acids and n-3 fatty acids is 3～4:1.
6. a kind of diabetes tailored version clinical nutrition formula according to claim 1, it is characterised in that the integration of edible and medicinal herbs
In composition, the parts by weight of each component are as follows：Rhizoma Polygonati 0-1 parts, Semen Sojae Preparatum 0-1 parts, Folium Mori 0-1 parts, Rhizoma Dioscoreae 0-1 parts, Fructus Crataegi 0-1
Part, Radix Glycyrrhizae 0-1 parts, Radix Platycodoniss 0-1 parts, Folium Nelumbinis 0-1 parts.
7. a kind of preparation method of diabetes tailored version clinical nutrition formula as claimed in claim 1, it is characterised in that described
Fat makes powder using microcapsule embedding techniqueses, and the integration of edible and medicinal herbs composition is by crushing, sieving and make powder.
8. preparation method according to claim 7, it is characterised in that the mesh number that the integration of edible and medicinal herbs composition sieves is 60-
80 mesh.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1515186A (en) * | 2003-08-25 | 2004-07-28 | 朱寿民 | Complete nutrients liquid food suitable for diabetic and its production method |
| CN104286849A (en) * | 2014-09-26 | 2015-01-21 | 上海励成营养产品科技股份有限公司 | Diabetes-specific enteral nutrition multi-polymerization agent |
| CN105029410A (en) * | 2015-06-29 | 2015-11-11 | 南阳市汇博生物技术有限公司 | Diabetes full nutrition emulsion formula food and preparation method thereof |
| CN105942498A (en) * | 2016-05-05 | 2016-09-21 | 上海诗琳美生物科技有限公司 | Functional nutritional food compounds with diabetes-treating effects and preparation methods thereof |
| CN106174585A (en) * | 2016-06-30 | 2016-12-07 | 山东凤凰生物有限公司 | Hypoglycemic compositions and hypoglycemic compound probiotic spy's dietary seafood |
-
2016
- 2016-12-23 CN CN201611208110.2A patent/CN106579393A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1515186A (en) * | 2003-08-25 | 2004-07-28 | 朱寿民 | Complete nutrients liquid food suitable for diabetic and its production method |
| CN104286849A (en) * | 2014-09-26 | 2015-01-21 | 上海励成营养产品科技股份有限公司 | Diabetes-specific enteral nutrition multi-polymerization agent |
| CN105029410A (en) * | 2015-06-29 | 2015-11-11 | 南阳市汇博生物技术有限公司 | Diabetes full nutrition emulsion formula food and preparation method thereof |
| CN105942498A (en) * | 2016-05-05 | 2016-09-21 | 上海诗琳美生物科技有限公司 | Functional nutritional food compounds with diabetes-treating effects and preparation methods thereof |
| CN106174585A (en) * | 2016-06-30 | 2016-12-07 | 山东凤凰生物有限公司 | Hypoglycemic compositions and hypoglycemic compound probiotic spy's dietary seafood |
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Application publication date: 20170426 |