CN107440102A - A kind of climacteric women tailored version clinical nutrition formula and preparation method thereof - Google Patents

A kind of climacteric women tailored version clinical nutrition formula and preparation method thereof Download PDF

Info

Publication number
CN107440102A
CN107440102A CN201710730062.1A CN201710730062A CN107440102A CN 107440102 A CN107440102 A CN 107440102A CN 201710730062 A CN201710730062 A CN 201710730062A CN 107440102 A CN107440102 A CN 107440102A
Authority
CN
China
Prior art keywords
powder
vitamin
clinical nutrition
climacteric women
tailored version
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710730062.1A
Other languages
Chinese (zh)
Inventor
尤俊
季敬东
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Olympic Medical Biotechnology Co Ltd
Original Assignee
Shanghai Olympic Medical Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Olympic Medical Biotechnology Co Ltd filed Critical Shanghai Olympic Medical Biotechnology Co Ltd
Priority to CN201710730062.1A priority Critical patent/CN107440102A/en
Publication of CN107440102A publication Critical patent/CN107440102A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The present invention relates to a kind of climacteric women tailored version clinical nutrition formula, and it includes protein, fat, carbohydrate, dietary fiber, macroelement, trace element, liposoluble vitamin, water soluble vitamin, meals elite, integration of drinking and medicinal herbs composition, natural plants compound and new resource food；The invention further relates to the preparation method of above-mentioned clinical nutrition formula, powder is made in its each component in advance, and powder is made using alcohol extracting water extraction concentration, spray drying in integration of drinking and medicinal herbs composition, and vitamin and fat are handled by microencapsulation is made powder；Or powder is made to each component progress emulsifying homogeneous, spray drying by wet processing.Screening and proportioning by said components, nutrient formulation of the present invention provide the nutritional support of comprehensive abundance for climacteric women, to adjust female incretion, keep hormone normal secretions, alleviate climacteric various symptoms；Recover the metabolic function of reinforcement human body and organ, delay bone loss, anti-aging.

Description

A kind of climacteric women tailored version clinical nutrition formula and preparation method thereof
Technical field
The present invention relates to special medicine purposes formula food field, and in particular to a kind of clinical battalion of climacteric women tailored version Support formula and preparation method thereof.
Background technology
Climacteric refers to that the female middle-aged of 45-55 year stops the natural process of menstruation.Menopause also can be due to ovariectomized Surgical operation or chemotherapy cause.Natural climacteric, which is one, includes premenopause (4~6 years), climacteric (not having menstruation in 1 year) With the slow process of postmenopause.Involutional adverse reaction includes night sweat, flush, anxious state of mind, insomnia, fatigue etc., these Reaction occurs at any time climacteric, but premenopause is most.Each women knows from experience difference for involutional, some People's symptom is slight and some people are very heavy.
Control the intake of heat：Because climacteric is that women is stepped into an old transition period, machine by the middle age Internal various functions start to weaken, and along with activity is reduced, basic metabolism reduces, the relative reduction of needs to heat, therefore If do not paid attention to, reasonable diet is easy to get fat involutional women.As long as daily staple food can meet the requirement of body, no It can eat and drink immoderately, in case overnutrition, causes middle aged " putting on weight ".
Ensure the supply of protein：Protein be maintenance and repair tissue material base, climacteric ovarian function Degenerate, internal sex hormone reduces, and some tissue organ functions also fail therewith, to relax this degeneration, maintain its function, just needs Ensure the intake of appropriate protein.
Low fat, low suger diet：Climacteric women decrease in estrogen, the adjustment effect of blood fat is weakened, often gone out Existing high fat of blood.High fat diet can raise blood fat, and influence of the different aliphatic acid to blood fat is also different.Climacteric women is usually preferably taken the photograph Enter appropriate polyunsaturated fatty acid, can significantly reduce cholesterol and low-density lipoprotein cholesterol level in blood plasma, and TG will not be raised.
Multivitamin：Vitamin is a kind of organic substance necessary to maintaining human life activity, is also to maintain human body The important active substances of physiological health.Although content of the vitamin in human body is seldom, it is in the growth of human body, development and new Played an important role during old metabolism.The women to enter into the climacteric period, the intake of appropriate vitamin, body can be helped Strengthen immunity, mitigate menopause symptom, also anti-aging, antitumaous effect.
Mineral matter needed by human：The vital movement of mineral matter and human body, metabolism, immunologic function, grow and Body aging etc. is closely related.They are to maintain enzyme and the indispensable material of various hormonal activities.Climacteric women is due to body Interior Ca,P metabolism is disorderly, sclerotin decalcification and osteoporosis easily occurs, it should be specifically noted that replenishing the calcium.
Dietary fiber and water：Cellulose can promote enterocinesia, keep free movement of the bowels, reduce noxious material and stop in enteron aisle The time is stayed, there is protective effect on cancer risk；The absorption of carbohydrate can be delayed, advantageously reduce blood glucose；Portion of cellulose expands under one's belt, People is allowed to produce satiety, so as to reduce the intake of heat.There is no water just there is no life, female middle-aged should be noted that to drink water more, this Be advantageous to eliminate internal metabolite, beauty and the generation for preventing disease.
In a word, climacteric is women special and important period in life, will either step into involutional female Property, be still in involutional women, will scientific rational diet nutritional, pass through diet care, mitigate climacteric The malaise symptoms of phase, anti-aging.
Doctor trained in Western medicine thinks that the hypoestrogenemia of menopausal women is substantially the basis of menopausal symptom.Estrogen level Excessively reduce, cause neurotransmitter, hormone, cell factor caused by the dysfunctions such as hypothalamic-pituitary-ovarian axis or adrenal gland It is unbalance Deng producing, it is the main reason for menopausal syndrome occurs.
Traditional Chinese medicine thinks, this sick etiology and pathogenesis duty in kidney.Kidney qi degradation before and after climacteric, menses will exhaust, and punching, which is appointed, loses Damage, asthenia of essence and blood, cause imbalance between YIN and YANG, function is disorderly and menopausal syndrome occurs.Clinical common parting is kidney The deficiency of Yin, kidney-yang deficiency, kidney insufficiency, fire excess from yin deficiency, breakdown of the normal physiological coordination between the heart and the kidney, the insufficiency of both the spleen and the kindey, the insufficiency of heart and spleen, stagnation of liver qi, deficiency of Yin liver-yang hyperactivity, Kidney deficiency folder stasis of blood etc..
Hormonotherapy is born in the forties in last century, is mainly used in improving menopausal syndrome, is only just had more than in the U.S. 40% climacteric women takes female hormone alternative medicine, but the climacteric women for only having 1% in China receives estrogen treatment Method, many public are also unfamiliar with to this treatment means, and the security of particularly some menopausal syndromes patient for treatment has Misgivings.Chinese medicine menopausal syndrome is curative for effect, few side effects, it is shown that good prospect.But traditional Chinese medicine is to climacteric The shortages such as the etiology and pathogenesis of phase syndrome, differentiation of symptoms and signs for classification of syndrome, efficacy evaluation unified standard, clinical prescription is numerous and diverse, and research work is excessively It is scattered.
Therefore, while development can provide the basal nutrient element needed for climacteric women, and can alleviates climacteric women The product of symptom has important value and wide market.
The content of the invention
A kind of the defects of it is an object of the invention to overcome in the prior art, there is provided climacteric women tailored version clinical nutrition Formula and preparation method thereof, it provides the nutritional support of comprehensive abundance for climacteric women, and researches and develops and be rich in vitamin B6And ammonia Sour, the enough calcium of base and vitamin D, the product for having additional nutrients, improving passive protective physical fitness for supplementing appropriate estrogen, realize female Property climacteric more preferable transition.Nutrient refers to provide energy to human body in food, participates in body composition and regulation of physiological functions Chemical composition.Nutrition necessary to human body is known as protein, lipid, carbohydrate, mineral matter, vitamin, water, dietary fiber etc..
To achieve the above object, the present invention adopts the following technical scheme that：
First purpose of the present invention is to provide a kind of climacteric women tailored version clinical nutrition formula, including following component And its parts by weight：15~20 parts of protein, 12~18 parts of fat, 40~54 parts of carbohydrate, 3.9~5.3 portions of property meals Fiber, 0.7~1.6 part of macroelement, 0.01~0.04 part of trace element, 0.005~0.02 part of liposoluble vitamin, 0.1~ 0.2 part of water soluble vitamin, 0.05~2 part of meals elite, 0.2~2 part of integration of drinking and medicinal herbs composition, 0.1~3 part of natural plants Compound and 0.02~2 part of new resource food.
In order to further optimize above-mentioned clinical nutrition formula, the technical measures that the present invention is taken also include：
Preferably, the protein be selected from PURE WHEY, soybean protein isolate, hydrolysis Isin glue collagen, whole milk powder, At least one of skimmed milk power, dried whole-egg, lactoferrin, bovine colostrum, amino acid, protein peptides；Wherein egg in whole milk powder White matter content is 24wt%, fat content 34wt%, carbohydrate content 40wt%.
Wherein, the amino acid is selected from 1B-Pidolidone, Pidolidone, L-arginine, L-Trp, L- paddy At least one of glutamine, taurine, Valine, ILE, L-Leu；The protein peptides are selected from soy oligosaccharides In peptide, wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide, laughable peptide, amino peptide, ovalbumin peptide, CCP It is at least one.
It is highly preferred that the protein includes PURE WHEY, soybean protein isolate, whole milk powder, bovine colostrum, hydrolysis Isin glue collagen, taurine.
Preferably, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structures At least one of fat, DHA, EPA, ARA, phosphatide, more specifically described fat include safflower seed oil, walnut oil, peanut oil, Soybean oil, Ah's glycerine, olive oil, tea oil, oil and fat of sacha inchi, olive oil, coconut oil, perilla herb oil, deep sea fish oil, cupu oil, palm Oil, butter, cream, lard, medium chain triglyceride, lecithin, Purple Perilla Seed Oil etc.；More preferably olive oil, soybean oil, coconut Oil, perilla herb oil, medium chain triglyceride.
Preferably, in above-mentioned nutrient formulation, the weight ratio of ω -6 aliphatic acid and omega-fatty acid is 4：1.
Preferably, the carbohydrate is included in fructose, rock sugar, lactose, maltodextrin, tapioca, resistant starch At least two；More preferably maltodextrin, tapioca, rock sugar.
Preferably, the dietary fiber include inulin, konjaku flour, galactooligosaccharide, FOS, oligoisomaltose, At least one of soybean polyoses, cyclodextrin, resistant dextrin, soybean fiber；It is highly preferred that the dietary fiber includes 3~4 parts Water-soluble dietary fiber and 0.9~1.3 part of insoluble diedairy fiber, it includes galactooligosaccharide and soybean fiber.
Preferably, the macroelement is selected from calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, K-IAO, sodium citrate At least one of with magnesium gluconate.
Preferably, the trace element is selected from ferrous gluconate, KI, zinc gluconate, sodium selenite, glucose At least one of sour copper, chromium sulfate, manganese gluconate and sodium molybdate.
Preferably, the liposoluble vitamin is selected from vitamin A, beta carotene, vitamin D3, vitamin E, vitamin K1At least one of.
Preferably, the water soluble vitamin is selected from vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, at least one of pantothenic acid, folic acid, nicotinic acid, choline, inositol, biotin.
Preferably, the meals elite is selected from cereal, beans, potato class, greengrocery, Homonemeae, nut-seed class, fishes and shrimps At least one of class, poultry meat, fruits；The cereal is selected from rice meal, millet powder, black rice flour, coixlacrymajobi powder, corn At least one of powder, wheat germ powder, oatmeal, buckwheat；The beans is selected from peameal, mung bean flour, black bean powder, red bean At least one of powder, soy meal；The potato class is mainly made up of common yam rhizome powder；The Vegetable powder is selected from carrot meal, white radish powder, south At least one of melon powder, spinach powder, tomato meal, broccoli powder, balsam pear powder；The Homonemeae be selected from mushroom powder, Kelp Powder and At least one of white fungus powder；The nut-seed class is selected from least one of pumpkin seed powder and lotus nut starch；The fish and shrimp Selected from least one of salmon powder and cod meal；The poultry meat is selected from chicken meal, powdered beef, pork liver powder and pig kidney powder At least one of；The fruits in red date powder, longan powder, apple powder, cherry powder, citrus powder, pyrus nivalis powder at least It is a kind of；More preferably soy meal.
Preferably, the natural plants compound is selected from l-cn, Glucosamine, FOS, lutein, plant At least one of sterol, lycopene, resveratrol, allicin；More preferably l-cn.
Preferably, the integration of drinking and medicinal herbs composition is selected from Poria cocos, orange, donkey-hide gelatin, orange peel, the root of kudzu vine, sea-buckthorn, emblic, anise At least one of fennel.
It is highly preferred that the parts by weight of each component are as follows in the integration of drinking and medicinal herbs composition：Orange 0~1 part, donkey-hide gelatin 0~1 Part, 0~1 part of orange peel, 0~1 part of the root of kudzu vine, 0~1 part of sea-buckthorn, 0~1 part of emblic, 0~1 part of Chinese anise.
Preferably, the new resource food is selected from first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo Leaf flavones, CPP, avenabeta glucosan, Oligomeric manna sugar, stachyose, Rosa roxburghii, yeast beta-dextran, newborn mineral At least one of salt, pueraria root powder, xylo-oligosaccharide, L-arabinose；It is highly preferred that the new resource food be newborn mineral salt, L-arabinose and γ-aminobutyric acid.
Above-mentioned nutrient formulation can also add appropriate seawood meal, more fully to supplement related nutritional element, improve climacteric The health of women.The seawood meal includes seawater spirulina powder, chlorella powder, Dunaliella peircei powder, ulva lactuca powder, Kelp Powder, skirt Vegetable powder, laver powder, kelp powder, Algemin, deer horn vegetable powder and kylin vegetable powder etc., food-borne marine algae is rich in algin, sweet dew Alcohol, vitamin and multi mineral the prime element such as trace element such as potassium, iron, calcium, phosphorus, iodine, selenium, cobalt, also 10%- containing crude protein 40%, crude fat 0.30%-50%, carbohydrate 30%-60%.Scientific investigations showed that seawood meal can adjust human body Metabolic function, strengthen immunity, health care, brain and enhancing intelligence, anti-aging are mended, Thyroid Gland Swell, nephrosis can be prevented, strengthen skin Gloss and elasticity, softening blood vessel, reduce cholesterol；Obesity, hypertension, cardiovascular disease etc. can be prevented with lipid-loweringing, decompression.
Second object of the present invention is to provide a kind of preparation side of above-mentioned climacteric women tailored version clinical nutrition formula Method method, it comprises the following steps：
Step 1) prepares fat powder, liposoluble vitamin powder and water soluble vitamin powder using micro-capsule embedding techniques End；
Step 2) prepares integration of drinking and medicinal herbs component powders using crushing, alcohol extracting, water extraction, spray drying and sifting step；
Step 3) is smart by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals China, natural plants compound and new resource food are prepared into the powder that particle diameter is 150~250 μm respectively, if desired Above-mentioned raw materials can be carried out in advance baking processing；
Step 4) is by step 1)~3) sterilize after the powder for preparing is well mixed it is standby；
The mixed powder of step 4) is prepared into nutrient powder, nutrition emulsion, capsule by step 5) according to conventional technical means At least one of agent, tablet, pill or oral liquid；
Wherein, step 1) -3) order can mutually change.
Finally, the present invention relates to a kind of product prepared by above-mentioned climacteric women tailored version clinical nutrition formula, including Nutrient powder, nutrition emulsion, capsule, tablet, pill, oral liquid etc..
In above-mentioned preparation method, wherein, the raw material of the integration of drinking and medicinal herbs composition is crushed, alcohol extracting concentration, water extraction are dense Contracting, and concentrate is subjected to spray drying integration of drinking and medicinal herbs component powders are made；Wherein, the vitamin and fat are respectively by micro- Encapsulated processing is prepared into vitamin powder and fat powder.
Preferably, the preparation process of the integration of drinking and medicinal herbs component powders is as follows：Using pulverizer to predetermined weight number Raw material is crushed, and the raw material of crushing is placed in container, adds 3~5 times of 60~80% second that weight is raw material weight Alcohol, soaked, extracted 2 times, merged alcohol extract and be concentrated into no alcohol taste；After the active compound dregs of a decoction fling to ethanol, weight is added as original 6~8 times of water of material weight is soaked, and is carried out 30~60min of decoction to soak, is filtered off except raw material, leaves and takes decoction Liquid；Merge alcohol extract and decoction liquor after concentration, and it is spray-dried, it is same finally to prepare medicine food with 60~80 mesh sieves point Derived components powder.
Preferably, what the microencapsulation of the vitamin was handled comprises the following steps that：1) using liposoluble vitamin as core Material, from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, big Beans protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean fiber, lactose, rock sugar One or more in powder, emulsifying agent, stabilizer high-pressure homogeneous emulsification, are sprayed instantaneous dry, with 60~80 mesh sieves as wall material Divide and prepare liposoluble vitamin powder；2) using water soluble vitamin as core, from sodium carboxymethylcellulose, gelatin, OK a karaoke club Glue, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, chrysanthemum One or more works in powder, PURE WHEY, oligoisomaltose, soybean fiber, lactose, candy sugar powder, emulsifying agent, stabilizer For wall material, it is well mixed, sprays instantaneous dry, water soluble vitamin powder is prepared with 60~80 mesh sieves point.
Preferably, the specific implementation step of the fatty micro-capsule embedding techniques is as follows：By fat, emulsifying agent, wall material with Water mixed dissolution prepares emulsion；After above-mentioned emulsion is stirred, emulsifying homogeneous processing is carried out, it is dry then to carry out spraying Dry, screening prepares fat powder, and fat powder is compared with conventional grease, and its dispersiveness, water solubility, emulsibility, inoxidizability are all Improve a lot；Wherein, the emulsifying agent be selected from fatty acid glyceride (glyceride), methyl glycol fatty acid ester (propylene glycol ester), One in sorbitan aliphatic ester (sorbitan acid), sucrose fatty ester (sucrose ester), lecithin, monoglyceride, Tween 80 Kind is a variety of；The wall material is selected from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, fat egg In vain, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean One or more in fiber, lactose, candy sugar powder, emulsifying agent, stabilizer.
The present invention also provides a kind of preparation method of above-mentioned climacteric women tailored version clinical nutrition formula, and it is wet method work Skill, comprise the following steps：
Step 1) prepare the protein containing predetermined weight number, fat, carbohydrate, dietary fiber, macroelement, Trace element, vitamin, integration of drinking and medicinal herbs composition, the raw material of natural plants compound and new resource food, in scheduled volume In water, according to the physical behavior of raw material, added successively according to sequencing, be stirred while addition, raw material is made Mixed emulsion；
The mixed emulsion temperature that step 1) obtains is maintained at 40-50 DEG C by step 2), and adjustment homogenization pressure makes it protect all the time Hold between 10-18Mpa, emulsifying homogeneous is carried out to mixed emulsion, then placed emulsion in evaporator, with default technology Parameter is concentrated, and is sterilized at 85-88 DEG C, obtains concentrate；
The concentrate that step 2) obtains is spray-dried by step 3), is crossed 60~80 mesh sieves, is prepared into powder；Using upper State powder and be prepared at least one of nutrient powder, nutrition emulsion, capsule, tablet, pill or oral liquid.
In the present invention using include orange, donkey-hide gelatin, orange peel, the root of kudzu vine, sea-buckthorn, emblic, Chinese anise integration of drinking and medicinal herbs into Point, there is the effect of regulation equilibrium between yin and yang and function, resistance building, anti-aging, energy after mentioned component compatibility synergy It is effectively improved the organism physiology, biochemistry and immunologic function of climacteric patient.
It is orange that there is obvious correction disorders of lipid metabolism, cholesterolemia, triglyceride and beta Lipoprotein are reduced, softens blood Pipe, improve microcirculation, antiatherosclerosis, suppress platelet aggregation and reduce blood viscosity, be advantageous to blood circulation, accelerate The effect of removing and the excretion of lipid residual particles (waste)；Pummelo peel general flavone has obvious to chronic alcohol liver injury Protective effect, general flavone have obvious oxidation resistant effect；Orange volatile oil has gentle stimulation to intestines and stomach, is advantageous to The discharge of gastrointestinal pneumatosis, and the secretion of gastric juice can be promoted, help to digest；Volatile oil can also stimulate respiratory mucosa, make secretion Thing increases, and sputum dilution, is advantageous to discharge；There is significant antibechic, eliminating the phlegm, anti-inflammatory, bacteriostasis simultaneously.
There is donkey-hide gelatin significant anti-anemia action to act on, and significantly shorten the external clotting time, moreover it is possible to blood loss anemia is treated, its There are promotion and protective effect to accompany and draw the hematopoiesis function of medulla hematopoietic system；Red blood cell, blood red egg of the donkey-hide gelatin to ischemic animal White etc. to have significant facilitation, the propagation and differentiation donkey-hide gelatin that can promote body candidate stem cell also have Antishock function, And it can improve calcium balance in animal body, promote Healthy Individuals transformation.
Orange peel has conditioning digestive system, strengthens functions of intestines and stomach, and cholagogic is aid digestion, reduces, is digested not for insufficiency of the spleen diet Good and nausea and vomiting etc..Orange peel can promote the secretion of digestive juice, exclude enteral pneumatosis.Intestines caused by anti-acetylcholine are received Contracting.Also can intestinal tube spasmodic contraction caused by antagonism pilocarpinum and barium chloride.Shorten the Migrating Myoelectric Complex week of small intestine Phase, improve the digestive function of small intestine.Active ingredient-aurantiamarin has excitation to stomach smooth muscle, can substantially antagonism Ah Gastric emptying and small intestine push inhibitory action caused by tropine, adrenaline.Hesperidin methyl substantially Inhibition test stomach can burst The generation of ulcer, and the effect of also anti-gastric acid secretion；Hesperidin methyl can make rat gallbladder contraction, solid in bile and bile The excretion increase of material, uses VC and VK4 if merging, can strengthen cholagogic effect.
Flavonoid substances in the root of kudzu vine have refrigeration function, and Puerarin has slight reduction blood glucose and prevented and treated diabetes complicated The effect of disease；The flavones ingredient of separation and purification can significantly inhibit erythrocyte hemolysis caused by oxidative damage from the root of kudzu vine, to micro- The generation of lipid peroxide has inhibitory action caused by the active oxygen of plastochondria；Kudzu root extract can strengthen macrophage phagocytosis carbon The function of grain.
Sea-buckthorn contains abundant protein, electrolytes and minerals and unrighted acid, promotes human metabolism, There can be good action to recovering body.White anthocyanidin, guassin, cumarin contained by sea-buckthorn etc. have obvious antitumaous effect, have Suppress the effect of sarcoma, melanoma, leukaemia, stomach cancer；Flavones in sea-buckthorn has improvement heart blood supply effect, and the anti-rhythm of the heart loses Often, anti-hyperlipidemia；SOD of the Seabuckthorn Oil also containing abundant scavenging activated oxygen effect, is important anti-aging material；Sea-buckthorn In the effective ingredient such as flavones have and remove human free radical, body's immunity can be remarkably reinforced.
Emblic can significantly inhibit the development of acute inflammation, improve and alleviate inflammatory symptoms, and it has reducing blood lipid and resisted dynamic Pulse atherosclerosis act on；Emblic has stronger lipoid peroxidization resistant, can improve antioxidant ability of organism, has protection The effect of function of vascular endothelium；Emblic fruit extract can suppress 1,2,3,-thrihydroxy-benzene and adrenergic autooxidation, contain Active material SOD, it can remove superoxide radical, play its anti-aging effects；Emblic butanol fraction is to real caused by indocin The property tested gastric mucosa damage has significant protective effect, and it has killing and inhibitory action to fraction of pathogens bacterium；Emblic can strengthen swollen The NK cells of knurl animal or the activity of K cells, emblic are made to human lymphocyte without induction DNA and chromosome damage in vitro With body's immunity can be strengthened by being improved cellular immunity with the effect of cell propagation, emblic is suppressed, and improve the disease-resistant energy of human body Power.
Chinese anise water decoction has inhibitory action to tubercle bacillus and hay bacillus, and its ethanol extract is to golden yellow grape Coccus, pneumococcus, corynebacterium diphtheriae, comma bacillus right cold bacillus, paratyphosum Bacterium, shigella dysenteriae and some common germs have compared with High inhibition acts on；Chinese anise also has function of increasing leukocyte, analgesic activity and suppresses platelet aggregation.
Compared with prior art, the invention has the advantages that：
(1) supplement various nutrients general equilibrium of the present invention, at the same add have regulation equilibrium between yin and yang and function, The integration of drinking and medicinal herbs composition of the effect of resistance building, anti-aging, and effective drug effect is extracted using the method for water extraction alcohol extracting comprehensively Material, while involutional malaise symptoms are helped improve, the taste ability for improving climacteric women is played, strengthens all kinds of battalion Support the absorption of material.
(2) ω -6 systems/ω -3 is that the weight ratio of polyunsaturated fatty acid is 4 in nutrient formulation of the present invention:1, meet China Intake of the crowd to fat matches, and easily absorbs；And blood fat is advantageously reduced, softens blood vessel, reduces blood pressure, promote other Nutrients Absorption utilizes.
(3) prebiotics such as present invention addition galactooligosaccharide, breed Bifidobacterium in enteron aisle, suppress blood glucose rise, treatment Constipation, promote the absorption of nutrient ingredients such as vitamin and mineral, reduce serum cholesterol, enhancing immunity of organisms, help fat-reducing.
(4) present invention uses the compound calcium source of scientific matching, selected calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, newborn mineral Four kinds of compound calcium sources of salt, scientific matching, improve calcium absorptivity and bioavailability, no constipation and gastrointestinal reaction.
(5) CCP is strengthened in nutrient formulation of the invention, CCP (CCP) forms complex compound with calcium, protects The dissolved state of calcium in the gastrointestinal tract is held, compound amino acid forms solvable state with calcium；Strengthen iron, zinc, iron is the blood red egg of synthesis White important source material, and form the required composition of various metalloenzyme or the confactor of some metalloenzyme of activation；Zinc participates in dimension The metabolism of vitamin A is held, the sense of taste, memory function are had a certain impact, zinc participates in cellular immunity and humoral immunity process, preventing and treating Resistance reduces.
(6) present invention prepares vitamin using micro-capsule embedding techniques, and vitamin is embedded in wall material, can prevent dimension from giving birth to Element is destroyed by macroelement, trace element, extends the holding time of vitamin；The present invention is prepared using micro-capsule embedding techniques Powdered oil so that powdered oil has preferable mobility, is easy to be well mixed with other powdered components；And use micro-capsule bag After burying technology, grease is embedded in wall material, so as to avoid the contact with air to strengthen inoxidizability, is protected so as to play The maximum effect of strong type grease.
(7) raw material of climacteric women tailored version clinical nutrition formula of the present invention is made in advance in preparation process For into 150~250 μm of powder, this make it that, when preparing finished product, each nutrition composition can be well mixed, in guarantor unit's volume Each nutrition composition content it is essentially identical, while when preparing liquid type preparation, each nutrition composition can be fully dispersed and complete It is dissolved in solvent, prevents occurring solid precipitation in liquid, the effect of finished product product has been effectively ensured.
The present invention is by the way that from rational basal nutrient element, using the proportioning of general equilibrium, while adding has regulation cloudy Rising tone weighs and function, resistance building, the integration of drinking and medicinal herbs composition of anti-aging, natural plants compound, new resource food Deng specific nutrient, and its proportioning and basal nutrient element progress compatibility synergy are adjusted, supplement the necessary nutritional ingredient of women comprehensively, and The nutrient formulation is easier to be digested and assimilated by climacteric women, the effect of giving full play to its each component, adjusts female incretion, changes Kind premenstrual syndrome and female physiological function；Keep hormone normal secretions, alleviate climacteric various symptoms；Recover to strengthen human body With the metabolic function of organ, delay bone loss, anti-aging.
Embodiment
The present invention provides a kind of climacteric women tailored version clinical nutrition formula, it is characterised in that including following component and Its parts by weight：15~20 parts of protein, 12~18 parts of fat, 40~54 parts of carbohydrate, 3.9~5.3 portions of property meals are fine Dimension, 0.7~1.6 part of macroelement, 0.01~0.04 part of trace element, 0.005~0.02 part of liposoluble vitamin, 0.1~0.2 Part water soluble vitamin, 0.05~2 part of meals elite, 0.2~2 part of integration of drinking and medicinal herbs composition, 0.1~3 part of natural plants compound And 0.02~2 part of new resource food.In the formula, the weight ratio of ω -6 aliphatic acid and ω -3 aliphatic acid is 4：1；Meals are fine Dimension includes 3~4 parts of water-soluble dietary fibers and 0.9~1.3 part of insoluble diedairy fiber.
With reference to embodiment, the embodiment of the present invention is further described.Following examples are only used for more Add and clearly demonstrate technical scheme, and can not be limited the scope of the invention with this.
Embodiment 1
Climacteric women tailored version clinical nutrition formula of the present invention includes PURE WHEY 10.33g, soybean separates Albumen 5.17g, whole milk powder 12g, bovine colostrum 0.33g, hydrolysis Isin glue collagen 0.17g, taurine 0.12g；Olive oil 2.64g, soybean oil 4.26g, coconut oil 2.64g, perilla herb oil 0.6g, medium chain triglyceride 0.2g；Maltodextrin 34.49g, cassava Starch 4.94g, rock sugar 6.3g；Water-soluble dietary fiber (including galactooligosaccharide) 3.5g, soybean fiber 1g；Calcium in macroelement 0.43g, phosphorus 0.236g, potassium 0.093g, sodium 0.248g, magnesium 0.148g；Iron 0.011g, zinc 0.008g in trace element；Vitamin A 0.0005g, β-carrotene 0.017g, vitamin D30.000001g, vitamin E 0.009g；Vitamin B10.001g, dimension Raw plain B20.001g, vitamin B60.001g, vitamin B120.0000013g, vitamin C 0.104g, pantothenic acid 0.003g, Folic acid 0.00023g, nicotinic acid 0.0133g；Soy meal 1.67g, orange 0.17g, sea-buckthorn 0.17g, donkey-hide gelatin 0.1g, Chinese anise It is 0.033g, emblic 0.17g, orange peel 0.17g, root of kudzu vine 0.2g, L-arabinose 0.07g, γ-aminobutyric acid 0.033g, left-handed Carnitine 0.63g, newborn mineral salt 0.1g, CCP 0.03g.
Embodiment 2
Climacteric women tailored version clinical nutrition formula of the present invention includes PURE WHEY 10.33g, soybean separates Albumen 5.17g, whole milk powder 12g, bovine colostrum 0.33g, hydrolysis Isin glue collagen 0.07g, taurine 0.12g；Olive oil 2.64g, soybean oil 4.26g, coconut oil 2.64g, perilla herb oil 0.6g, medium chain triglyceride 0.2g；Maltodextrin 34.49g, cassava Starch 4.94g, rock sugar 6.3g；Water-soluble dietary fiber (including galactooligosaccharide) 3.5g, soybean fiber 1g；Calcium in macroelement 0.43g, phosphorus 0.236g, potassium 0.093g, sodium 0.248g, magnesium 0.148g；Iron 0.011g, zinc 0.008g in trace element；Vitamin A 0.0005g, β-carrotene 0.017g, vitamin D30.000001g, vitamin E 0.009g；Vitamin B10.001g, dimension Raw plain B2 0.001g, vitamin B60.001g, vitamin B120.0000013g, vitamin C 0.104g, pantothenic acid 0.003g, Folic acid 0.00003g, nicotinic acid 0.0133g；Soy meal 0.07g, orange 0.17g, sea-buckthorn 0.17g, donkey-hide gelatin 0.1g, Chinese anise It is 0.033g, emblic 0.17g, orange peel 0.17g, root of kudzu vine 0.2g, L-arabinose 0.01g, γ-aminobutyric acid 0.003g, left-handed Carnitine 0.63g, newborn mineral salt 0.01g, CCP 0.03g.
Embodiment 3
Climacteric women tailored version clinical nutrition formula of the present invention includes PURE WHEY 10.33g, soybean separates Albumen 5.17g, whole milk powder 12g, bovine colostrum 0.33g, hydrolysis Isin glue collagen 0.07g, taurine 0.12g；Olive oil 2.64g, soybean oil 4.26g, coconut oil 2.64g, perilla herb oil 0.6g, medium chain triglyceride 0.2g；Maltodextrin 34.49g, cassava Starch 4.94g, rock sugar 6.3g；Water-soluble dietary fiber (including galactooligosaccharide) 3.5g, soybean fiber 1g；Calcium in macroelement 0.43g, phosphorus 0.236g, potassium 0.093g, sodium 0.248g, magnesium 0.148g；Iron 0.011g, zinc 0.008g in trace element；Vitamin A 0.0005g, β-carrotene 0.017g, vitamin D30.000001g, vitamin E 0.009g；Vitamin B10.001g, dimension Raw plain B20.001g, vitamin B60.001g, vitamin B120.0000013g, vitamin C 0.104g, pantothenic acid 0.003g, Folic acid 0.00003g, nicotinic acid 0.0133g；Soy meal 0.07g, orange 0.07g, sea-buckthorn 0.07g, donkey-hide gelatin 0.01g, Chinese anise It is 0.003g, emblic 0.07g, orange peel 0.07g, root of kudzu vine 0.02g, L-arabinose 0.01g, γ-aminobutyric acid 0.003g, left-handed Carnitine 0.63g, newborn mineral salt 0.01g, CCP 0.03g.
Embodiment 4
A kind of preparation method of the special clinical nutrition formula of climacteric women as described in 1~embodiment of embodiment 3 is as follows：
1) powdered oil (powder fat) is prepared：
A) the wall material aqueous solution is prepared：Take 8 grams of maltodextrin, 4 grams of soybean protein isolate, 11 grams of whole-fat milk powder, dietary fiber 2 Gram (resistant dextrin), 0.5 gram of inulin, 5 grams of PURE WHEY, 0.5 gram of oligoisomaltose, 1 gram of soybean fiber, Arabic gum 0.2 gram, 0.5 gram of lactose, 2 grams of candy sugar powder, 50 milliliters of water stirs and (has ready conditions and heat while stirring to 60 DEG C, kept for 30 points Room temperature is cooled to after clock).
B) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in (olive oil in 9.71 milliliters of greases monoglyceride 2.48 milliliters, 4.00 milliliters of soybean oil, 2.48 milliliters of coconut oil, 0.56 milliliter of perilla herb oil, 0.19 milliliter of medium chain triglyceride).
C) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in the wall material aqueous solution Tween 80.
D) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed.
E) after addition stabilizer agar takes 0.1 gram (total solid concentration is 0.2%) to enter mixed solution, it is settled to water 200 milliliters (total solid concentration be 25%), disperse 2 minutes at a high speed under 20000r/min.
F) homogenization pressure is 25MPa, homogeneous 3 times (every time 5 minutes), homogeneous emulsion is made.
G) obtained emulsion is spray-dried, EAT is 195 DEG C, and leaving air temp is 80 DEG C.Collect powder Grease (powder fat).
2) integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, the raw material of predetermined weight number is crushed using pulverizer, the raw material of crushing is placed in container In, 3~5 times of 60~80% ethanol that weight is raw material weight are added, is soaked, extracted 2 times, merges alcohol extract and concentrates To without alcohol taste；After the active compound dregs of a decoction fling to ethanol, add weight and soaked for 6~8 times of water of raw material weight, soak is entered Row decocts 30~60min, filters off except raw material, leaves and takes decoction liquor；Merge alcohol extract and decoction liquor after concentration, and it is carried out Spray drying, finally prepare integration of drinking and medicinal herbs component powders with 60~80 mesh sieves point；
3) vitamin powder is prepared：Using the liposoluble vitamin of predetermined weight number as core, from oligomeric different malt Sugar is used as wall material, carries out 2 emulsifying homogeneous processing under high pressure, the emulsifying homogeneous time is 10~15min, then carries out spraying wink When dry, point prepare liposoluble vitamin powder with 60~80 mesh sieves；Using the water soluble vitamin of predetermined weight number as core Material, from maltodextrin, oligoisomaltose as wall material, it is well mixed, sprays instantaneous dry, prepared with 60~80 mesh sieves point Water soluble vitamin powder；
4) by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals elite, Natural plants compound and new resource food are prepared into the powder that particle diameter is 150~250 μm respectively；(step 1) -4) order Can mutually it change)
5) by step 1) -4) prepare powder in the similar devices such as mixer be well mixed after sterilize it is standby；
6) the prepared food powder in step 5) is prepared into by the prepared food powder obtained by step 5) according to conventional technical means At least one of nutrient powder, nutrition emulsion, capsule, tablet, pill or oral liquid.
In step 6), optionally increase appropriate food thickening agent, food additives and related formulation auxiliary material. The food thickening agent is in guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum At least one, the food additives are Aspartame, flavoring essence spices, at least one of brown sugar；More preferably OK a karaoke club Glue, Arabic gum, guar gum, Aspartame, flavoring essence spices.
Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent from producing The danger of green powder blast.
According to described with the classifications such as powdery, graininess, capsule shape, tablet shape, beverage can be prepared into.
Embodiment 5
1) influence of nutrient formulation preparation prepared by the present invention to normal mouse；
A) acute toxicity test；
The nutrient powder prepared with the embodiment of the present invention 2,1 group of little Bai is given with 150 times of clinical consumption per day and 200 times respectively Mouse feeding is offerd medicine, and is observed 14；As a result all small white mouses are strong deposits, and its activity, diet, hair, excreta are no abnormal, have no Toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other adverse reactions.
B) long term toxicity test；
Nutrition powder prepared by the embodiment of the present invention 1 is dissolved in water to mouse by 3,10 and 24g nutrient powders/kg, to 3 Group mouse difference continuous use 12 weeks, 2 times a day, and after drug withdrawal 4 weeks, the results showed that：Chinese medicine of the present invention is to two groups of test mices Hair, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood glucose, the index such as blood fat have no significant effect, it is dirty Device naked eyes are without finding that difference change and histological indications show, after medication 12 weeks and drug withdrawal 4 weeks, the equal nothing of Organs of Mice It is obvious to change.Illustrate that nutrient formulation preparation of the present invention to small toxicity after mouse long-term prescription, does not have abnormal reaction yet, answered after drug withdrawal With safety.
2) therapeutic effect of nutrient formulation preparation prepared by the present invention to climacteric women patient；
The special clinical nutrition powder of climacteric women and comparative example provided from embodiment 1~3 (does not add integration of drinking and medicinal herbs The nutrient powder of composition) and control group (using hormone therapy), 100 climacteric women patients are chosen, 5 groups are divided into, to every One group is tested and is tracked interview.Experiment 6 months by a definite date, after 6 months are full, survey is carried out to every patient, for The nutrient powder is scored in terms of appetite is improved, improve constitution, improvement mood, improvement sleep and enhancing memory five, full marks 10 points, for patient according to actual conditions to dividing and averaging, result of calculation is as shown in the table shown.
As it can be seen from table 1 the special clinical nutrition powder of climacteric women that the embodiment of the present invention 1~3 is provided is improving Appetite, the constitution that improves, the mood that improves, improvement sleep and the effect of enhancing five aspects of memory are respectively provided with the effect of preferable, its effect Fruit is suitable with the hormone therapy effect that control group uses, but its side effect is less compared with control group；The effect of embodiment 1~3 is better than Comparative example.This absolutely proves the special clinical nutrition of climacteric women provided by the invention with can be to the situation of climacteric metancholia There is more obvious improvement, and its component can act synergistically with integration of drinking and medicinal herbs composition.
From above-described embodiment, various components are mutual in the special clinical nutrition formula of climacteric women of the present invention Coordinate, reasonable, comprehensive nutritional support is provided for climacteric women patient, to improve the condition of climacteric women patient, Addition has regulation equilibrium between yin and yang and function, resistance building, integration of drinking and medicinal herbs composition, the natural plants of anti-aging simultaneously Compound, new resource food, passive protective physical fitness is improved, anti-aging, realizes the more preferable transition of Menopause.
The specific embodiment of the present invention is described in detail above, but it is only used as example, and the present invention is not intended to limit In particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and to replace In generation, is also all among scope of the invention.Therefore, the impartial conversion made without departing from the spirit and scope of the invention and repair Change, all should be contained within the scope of the invention.

Claims (9)

1. a kind of climacteric women tailored version clinical nutrition formula, it is characterised in that including following component and its parts by weight：15 ~20 parts of protein, 12~18 parts of fat, 40~54 parts of carbohydrate, 3.9~5.3 parts of property dietary fibers, 0.7~1.6 part Macroelement, 0.01~0.04 part of trace element, 0.005~0.02 part of liposoluble vitamin, 0.1~0.2 part of water soluble vitamin life Element, 0.05~2 part of meals elite, 0.2~2 part of integration of drinking and medicinal herbs composition, 0.1~3 part of natural plants compound and 0.02~2 part New resource food；
Wherein, the integration of drinking and medicinal herbs composition is in Poria cocos, orange, donkey-hide gelatin, orange peel, the root of kudzu vine, sea-buckthorn, emblic, Chinese anise At least one；
Wherein, the dietary fiber includes 3~4 parts of water-soluble dietary fibers and 0.9~1.3 part of insoluble diedairy fiber.
2. a kind of climacteric women tailored version clinical nutrition formula according to claim 1, it is characterised in that in above-mentioned battalion Support in formula, the weight ratio of ω -6 aliphatic acid and omega-fatty acid is 4：1.
A kind of 3. climacteric women tailored version clinical nutrition formula according to claim 1, it is characterised in that the new money Source food is selected from first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo-leaves flavones, CPP, oat Beta glucan, Oligomeric manna sugar, stachyose, Rosa roxburghii, yeast beta-dextran, newborn mineral salt, pueraria root powder, Rosa roxburghii, xylo-oligosaccharide, L- At least one of arabinose.
A kind of 4. climacteric women tailored version clinical nutrition formula according to claim 3, it is characterised in that the new money Source food is newborn mineral salt, L-arabinose, γ-aminobutyric acid.
A kind of 5. climacteric women tailored version clinical nutrition formula according to claim 1, it is characterised in that the medicine food It is orange, donkey-hide gelatin, orange peel, the root of kudzu vine, sea-buckthorn, emblic, Chinese anise with derived components.
A kind of 6. climacteric women tailored version clinical nutrition formula according to claim 5, it is characterised in that the medicine food Parts by weight with derived components are as follows：Orange 0~1 part, 0~1 part of donkey-hide gelatin, 0~1 part of orange peel, 0~1 part of the root of kudzu vine, sea-buckthorn 0~1 Part, 0~1 part of emblic, 0~1 part of Chinese anise.
7. a kind of climacteric women tailored version clinical nutrition formula according to claim 1, it is characterised in that described natural Plant compound be selected from l-cn, Glucosamine, FOS, lutein, phytosterol, lycopene, resveratrol, At least one of allicin.
8. a kind of preparation method of such as climacteric women tailored version clinical nutrition formula according to any one of claims 1 to 7, It is characterised in that it includes following steps：
The fat, liposoluble vitamin, water soluble vitamin of step (1) predetermined weight are respectively adopted micro-capsule embedding techniques and prepared simultaneously Cross 60~80 mesh sieves and powder is made；
The integration of drinking and medicinal herbs composition of step (2) predetermined weight is made up of crushing, alcohol extracting, water extraction, spray drying and 60-80 mesh sieves excessively Powder；
Remaining component of step (3) predetermined weight is prepared into the powder that particle diameter is 150~250 μm respectively；
The powder that step (4) prepares step (1)~(3) is sterilized standby after being well mixed；
Direct-edible pharmaceutical formulation is made in step (4) mixed powder by step (5)；
Wherein, the order of step (1)~(3) can be changed mutually；The pharmaceutical formulation include nutrient powder, nutrition emulsion, capsule, Tablet, pill, oral liquid.
9. according to the preparation method of climacteric women tailored version clinical nutrition formula according to any one of claims 1 to 7, its It is characterised by, comprises the following steps：
Step 1) prepares the protein containing predetermined weight number and amino acid, nucleotides, fat, carbohydrate, meals are fine Dimension, macroelement, trace element, vitamin, integration of drinking and medicinal herbs composition, the raw material of natural plants compound and new resource food Powder, in the water of scheduled volume, according to the physical behavior of raw material, add according to sequencing, enter while addition successively Row stirring, the mixed emulsion of raw material is made；
The mixed emulsion that step 2) obtains step 1) carries out emulsifying homogeneous, concentrating sterilizing, obtains concentrate；
The concentrate that step 2) obtains is spray-dried by step 3), sieving, is prepared into powder, and above-mentioned powder is prepared into At least one of nutrient powder, nutrition emulsion, capsule, tablet, pill or oral liquid.
CN201710730062.1A 2017-08-23 2017-08-23 A kind of climacteric women tailored version clinical nutrition formula and preparation method thereof Pending CN107440102A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710730062.1A CN107440102A (en) 2017-08-23 2017-08-23 A kind of climacteric women tailored version clinical nutrition formula and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710730062.1A CN107440102A (en) 2017-08-23 2017-08-23 A kind of climacteric women tailored version clinical nutrition formula and preparation method thereof

Publications (1)

Publication Number Publication Date
CN107440102A true CN107440102A (en) 2017-12-08

Family

ID=60493795

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710730062.1A Pending CN107440102A (en) 2017-08-23 2017-08-23 A kind of climacteric women tailored version clinical nutrition formula and preparation method thereof

Country Status (1)

Country Link
CN (1) CN107440102A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108095075A (en) * 2017-12-13 2018-06-01 上海奥医生物医药科技有限公司 Miscarriage women tailored version clinical nutrition formula and preparation method thereof
CN108514109A (en) * 2018-05-10 2018-09-11 上海奥医生物医药科技有限公司 Anaesthetize postoperative tailored version clinical nutrition formula and preparation method thereof
CN108669540A (en) * 2018-05-10 2018-10-19 上海奥医生物医药科技有限公司 Cerebral apoplexy tailored version clinical nutrition formula and preparation method thereof
WO2021198957A1 (en) * 2020-03-31 2021-10-07 E.I.D.- Parry(India) Ltd. Plant-based nutritional composition, method of preparation and application thereof

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106490605A (en) * 2016-12-23 2017-03-15 上海奥医生物医药科技有限公司 A kind of hypertension of pregnancy tailored version clinical nutrition formula and preparation method thereof
CN106579460A (en) * 2016-12-23 2017-04-26 上海奥医生物医药科技有限公司 Special clinical nutrition formula for fracture and preparation method thereof
CN106579393A (en) * 2016-12-23 2017-04-26 上海奥医生物医药科技有限公司 Special clinical nutrient formula for diabetes and preparation method thereof
CN106616615A (en) * 2016-12-23 2017-05-10 上海奥医生物医药科技有限公司 Clinical nutrient formula special for tumor and preparation method of clinical nutrient formula
CN106666728A (en) * 2016-12-23 2017-05-17 上海奥医生物医药科技有限公司 Special clinical nutrient composition for gestational diabetes and preparation method of nutrient composition
CN106858595A (en) * 2017-03-29 2017-06-20 上海奥医生物医药科技有限公司 One kind burn tailored version clinical nutrition formula and preparation method thereof
CN106858620A (en) * 2017-03-29 2017-06-20 上海奥医生物医药科技有限公司 A kind of anaemia tailored version clinical nutrition formula and preparation method thereof
CN106942748A (en) * 2017-03-29 2017-07-14 上海奥医生物医药科技有限公司 A kind of female acyesis tailored version clinical nutrition formula and preparation method thereof
CN106962912A (en) * 2017-03-29 2017-07-21 上海奥医生物医药科技有限公司 A kind of hepatopathy tailored version clinical nutrition formula and preparation method thereof
CN106983151A (en) * 2017-03-29 2017-07-28 上海奥医生物医药科技有限公司 A kind of inflammatory bowel disease tailored version clinical nutrition formula and preparation method thereof
CN106983136A (en) * 2017-03-29 2017-07-28 上海奥医生物医药科技有限公司 A kind of puerperium conditioning tailored version clinical nutrition formula and preparation method thereof

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106490605A (en) * 2016-12-23 2017-03-15 上海奥医生物医药科技有限公司 A kind of hypertension of pregnancy tailored version clinical nutrition formula and preparation method thereof
CN106579460A (en) * 2016-12-23 2017-04-26 上海奥医生物医药科技有限公司 Special clinical nutrition formula for fracture and preparation method thereof
CN106579393A (en) * 2016-12-23 2017-04-26 上海奥医生物医药科技有限公司 Special clinical nutrient formula for diabetes and preparation method thereof
CN106616615A (en) * 2016-12-23 2017-05-10 上海奥医生物医药科技有限公司 Clinical nutrient formula special for tumor and preparation method of clinical nutrient formula
CN106666728A (en) * 2016-12-23 2017-05-17 上海奥医生物医药科技有限公司 Special clinical nutrient composition for gestational diabetes and preparation method of nutrient composition
CN106858595A (en) * 2017-03-29 2017-06-20 上海奥医生物医药科技有限公司 One kind burn tailored version clinical nutrition formula and preparation method thereof
CN106858620A (en) * 2017-03-29 2017-06-20 上海奥医生物医药科技有限公司 A kind of anaemia tailored version clinical nutrition formula and preparation method thereof
CN106942748A (en) * 2017-03-29 2017-07-14 上海奥医生物医药科技有限公司 A kind of female acyesis tailored version clinical nutrition formula and preparation method thereof
CN106962912A (en) * 2017-03-29 2017-07-21 上海奥医生物医药科技有限公司 A kind of hepatopathy tailored version clinical nutrition formula and preparation method thereof
CN106983151A (en) * 2017-03-29 2017-07-28 上海奥医生物医药科技有限公司 A kind of inflammatory bowel disease tailored version clinical nutrition formula and preparation method thereof
CN106983136A (en) * 2017-03-29 2017-07-28 上海奥医生物医药科技有限公司 A kind of puerperium conditioning tailored version clinical nutrition formula and preparation method thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108095075A (en) * 2017-12-13 2018-06-01 上海奥医生物医药科技有限公司 Miscarriage women tailored version clinical nutrition formula and preparation method thereof
CN108514109A (en) * 2018-05-10 2018-09-11 上海奥医生物医药科技有限公司 Anaesthetize postoperative tailored version clinical nutrition formula and preparation method thereof
CN108669540A (en) * 2018-05-10 2018-10-19 上海奥医生物医药科技有限公司 Cerebral apoplexy tailored version clinical nutrition formula and preparation method thereof
WO2021198957A1 (en) * 2020-03-31 2021-10-07 E.I.D.- Parry(India) Ltd. Plant-based nutritional composition, method of preparation and application thereof

Similar Documents

Publication Publication Date Title
CN107319525A (en) One kind fat-reducing fat reducing tailored version clinical nutrition formula and preparation method thereof
CN106983136A (en) A kind of puerperium conditioning tailored version clinical nutrition formula and preparation method thereof
CN106858620A (en) A kind of anaemia tailored version clinical nutrition formula and preparation method thereof
CN106962912A (en) A kind of hepatopathy tailored version clinical nutrition formula and preparation method thereof
CN109645320A (en) A kind of light jejunitas full nutrient formulation can brew instant stick and preparation method thereof
CN101473953B (en) Fabricated food for cleaning blood and expelling toxin as well as method for processing the same and application
CN108618129A (en) Sarcopenia tailored version clinical nutrition formula and preparation method thereof
CN107242550A (en) A kind of male sterility tailored version clinical nutrition formula and preparation method thereof
CN107440120A (en) A kind of children's monophagia and anorexia tailored version clinical nutrition formula particular about food and preparation method thereof
CN106983151A (en) A kind of inflammatory bowel disease tailored version clinical nutrition formula and preparation method thereof
CN107616490A (en) A kind of postoperative tailored version clinical nutrition formula of children and preparation method thereof
CN107319524A (en) A kind of nephrosis tailored version clinical nutrition formula and preparation method thereof
CN110074397A (en) A kind of upgrowth and development of children tailored version clinical nutrition formula and preparation method thereof
CN107440103A (en) A kind of respiratory disease tailored version clinical nutrition formula and preparation method thereof
CN107440121A (en) A kind of Single Obesity tailored version clinical nutrition formula and preparation method thereof
CN108013454A (en) Gynaecological imflammation tailored version clinical nutrition formula and preparation method thereof
JP2021526821A (en) Unchanged pea protein-based nutritional composition
CN108077911A (en) A kind of epileptic's tailored version clinical nutrition formula and preparation method thereof
CN107440102A (en) A kind of climacteric women tailored version clinical nutrition formula and preparation method thereof
CN107927754A (en) Tailored version clinical nutrition formula and preparation method thereof is energized during one kind production
CN108719984B (en) Meal replacement nutrition bar for gout population and preparation method thereof
CN108013453A (en) Children's lactose intolerance tailored version clinical nutrition formula and preparation method thereof
CN106858595A (en) One kind burn tailored version clinical nutrition formula and preparation method thereof
CN112118748A (en) Hydrolyzed pea protein based nutritional composition
CN108669540A (en) Cerebral apoplexy tailored version clinical nutrition formula and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20171208