CN107440103A - A kind of respiratory disease tailored version clinical nutrition formula and preparation method thereof - Google Patents

A kind of respiratory disease tailored version clinical nutrition formula and preparation method thereof Download PDF

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Publication number
CN107440103A
CN107440103A CN201710731367.4A CN201710731367A CN107440103A CN 107440103 A CN107440103 A CN 107440103A CN 201710731367 A CN201710731367 A CN 201710731367A CN 107440103 A CN107440103 A CN 107440103A
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powder
respiratory disease
vitamin
clinical nutrition
parts
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尤俊
季敬东
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Shanghai Olympic Medical Biotechnology Co Ltd
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Shanghai Olympic Medical Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The present invention relates to a kind of respiratory disease tailored version clinical nutrition formula, and it includes protein, fat, carbohydrate, dietary fiber, macroelement, trace element, liposoluble vitamin, water soluble vitamin, meals elite, integration of drinking and medicinal herbs composition, natural plants compound and new resource food；The invention further relates to the preparation method of above-mentioned clinical nutrition formula, powder is made in its each component in advance, and powder is made using alcohol extracting water extraction concentration, spray drying in integration of drinking and medicinal herbs composition, and vitamin and fat are handled by microencapsulation is made powder；Or powder is made to each component progress emulsifying homogeneous, spray drying by wet processing.Screening and proportioning by said components, nutrient formulation of the present invention provides the nutritional support of comprehensive abundance for respiratory disease patient, to improve passive protective physical fitness, certain effect is all achieved to nutritional status, respiratory function, the life quality for improving patient, more preferable condition is created for disease treatment.

Description

A kind of respiratory disease tailored version clinical nutrition formula and preparation method thereof
Technical field
The present invention relates to special medicine purposes formula food field, and in particular to a kind of respiratory disease tailored version is clinical Nutrient formulation and preparation method thereof.
Background technology
Respiratory system is an open system, and environment and the occurrence and development of its disease have close relationship；In recent years It was found that diet is also relevant with the generation of its disease, i.e., nutrient can adjust reaction of the human body to environmental poisonous substance.With atmosphere pollution Aggravation, the inducement such as pollution, passive smoking of indoor dust and interior decoration, all easily trigger respiratory disease.Nutrition with The relation of respiratory disease is mainly that nutrient can adjust reaction of the people to environmental poisonous substance, i.e. diet can suitably prevent environment not The influence of sharp factor, conversely then increase to environment unfavorable factor for example anaphylactogen, tobacco smoke, infection, atmosphere pollution neurological susceptibility.
Vit C and Vit E and beta carotene are antioxidants, and antioxidant is anti-for first of oxygen radical Line.In lungs, there is provided antioxidant defense effect in addition to endogenic enzyme and the anti-oxidant compounds of non-enzyme system, diet In antioxidant particularly Vit C, Vit E and beta carotene it is also critically important.Epidemiological study shows that serum Vit C are low Relevant with wheezing symptoms increase, its forced expiratory volume in one second (FEV1) of the diet intake less persons of Vit C is relatively low, and this influence It is particularly evident in asthma patient.But how the effect of supplementing Vit C to asthma patient there is no final conclusion at present.Beta carotene is Vit A precursor, it is deposited in tissue film, can remove O-2And peroxy radical can be directly acted on.Vitamin is to a certain extent Can be to the injury of lungs caused by antioxidant.
ω -3 and ω -6 aliphatic acid is relevant with the formation of airway inflammation.The how unsaturated aliphatic acid of ω -3 (ω -3PUFA) stores up Exist in cell membrane, played an important role in controlling inflammation, but it is easily substituted by ω -6PUFA, and the latter promotes the shape of inflammation Into.It is now recognized that high intake ω -3PUFA can reduce the synthesis of inflammatory mediator leukotriene, but ω -3 fat is supplemented to asthma patient Fat acid or fish oil but generate conflicting result.Subsequent people it has been observed that in diet ω -3 and ω -6 aliphatic acid ratio Example is probably key factor in inflammatory metabolic Product formation, rather than absolute magnitude.Other ω -3PUFA can also suppress prostate Plain E2 synthesis, thus reduce hypersensitive sensitization.
Sodium is extremely important at many aspects of regulation smooth muscle tension, therefore salt content high energy promotes airway disorders in diet Formation, particularly airway hyper-reaction.Other sodium can also pass through the horizontal change of endogenous steroids and the release of catecholamine Work.Magnesium also influences airway disorders, because it is relevant with the maintenance of cell membrane both sides current potential, and has bronchiectatic activity. Magnesium can relax airway smooth muscle in vitro, can expand the air flue of asthma person in vivo, can suppress the transmission of cholinergic nerve muscle, Stable loose and T- lymphocytes.
Malnutrition often occurs for COPD (COPD) patient, while with immunologic hypofunction.Nutrition The bad muscular strength and endurance for reducing respiratory muscle, makes respiratory muscle fatigue easily occur, and maximal ventilatory volume and lung capacity decline.Ventilation is dynamic Power reduces the secretion for making effectively cough reduce and can not exclude respiratory system；Malnutrition reduces ALB, it is difficult to maintains blood plasma Colloid osmotic pressure, tissue space oedema, the water content of lung increase, and influence the diffusion of oxygen；Malnutrition makes immunoglobulin (IgG) synthesis is reduced, and secretory IgA declines, and complement system activity reduces, the decline of neutrophil leucocyte bactericidal activity, blood leaching Bar Leukopenia, body's immunity decline, and defence and the repair function of respiratory system tissue decline, and make infection in respiratory system difficult To control or occur new infection；Malnutrition increases hormone in vivo level diacrisis, hyperglycemic factor, glucocorticoid etc. Add, hepatic glycogenolytic, gluconeogenesis increase, organize the Use barriers to sugar, blood glucose rise, easily make Lung infection delay not More.Malnutrition employs internal fat depot, and fat turns into the main source of energy, and Fatty Acids in Plasma increase, generation is largely Ketoboidies, cause metabolic acidosis, aggravate the burden of respiratory system.Therefore malnutrition causes respiratory system structure and function different Often, primary disease is aggravated, induces multiple complications, has a strong impact on the mobility and social function of patient, life quality reduces, Prognosis is bad, even results in death.
Apply glucocorticoid treatment respiratory disease at present.Glucocorticoid is occurred by suppressing or promoting with inflammation Develop the transcription of relevant some genes, suppress inflammatory process from many aspects.Glucocorticoid heavy dose short application use it is bad Reaction has：(1) disorder of spirit and central nervous system, shows as anxious state of mind, even spiritedness is not normal；(2) Impaired Glucose Tolerance Treated Even induced Diabetic；(3) water sodium storage is stayed；(4) disease of digestive tract and the symptom such as concurrent hemorrhage of gastrointestinal tract, peptic ulcer；(5) Blood pressure increases；(6) glaucoma is caused；(7) diseases such as acute myopathy are induced；(8) heavy dose of too fast administration, it is accidental to have allergy anti- Should.The adverse reaction of prolonged application has：(1) suppression of hypothalamic-pituitary-adrenal (HPA) axle makes corticotropin (ACTH) secretion with cortin is reduced, and can cause iatrogenic adrenocortical insufficiency, severe patient may occur in which on kidney Gland crisis；(2) the hyperfunction syndrome of class adrenal cortex function (cushing's syndrome)；(3) there is antigrowth hormone, can Influence children's bone growth and development；(4) old man and menopausal women osteoporosis and sclerotin can be caused to lower；(5) chronic myopathy； (6) induce or aggravate infection；(7) wound healing is slow, atrophoderma.The effect of the doctor trained in Western medicine control course of disease is not very notable, in Doctor is so in diagnosis and treatment based on an overall analysis of the illness and the patient's condition and the side's of sending medication, and because clinical experience and individual realize difference, numerous doctor's views are not quite similar, such as mulberry Bai Pitang is applied to phlegm-heat accumulated in the lung type COPD, and the dynamics of resolving sputum and heat-clearing is not to same sufferer medication, in its side by different researchers Together, it is and also different in the selection of medicinal material, resolving sputum Chinese medicine is such as directed to, someone is kind to use Poria cocos strengthening the spleen and reducing phlegm, and someone likes dry with rhizoma atractylodis Humidifying phlegm, or both dual-purpose, etc., its single medicine dosage also has difference.The medication specification of the traditional Chinese medical science be difficult uniformly, it is empirical By force.
Therefore, while development can provide the basal nutrient element needed for respiratory disease patient, and can is alleviated and controlled The product for treating respiratory disease symptom has important value and wide market.
The content of the invention
A kind of the defects of it is an object of the invention to overcome in the prior art, there is provided the clinical battalion of respiratory disease tailored version Formula and preparation method thereof is supported, it provides the nutritional support of comprehensive abundance for respiratory disease, and the nutrient formulation not only contains Balanced three major nutrient, also containing multivitamin and mineral matter, there is provided high quality nutrition, strengthen immunologic function.Give EN support, certain effect is all achieved to nutritional status, respiratory function, the life quality for improving patient, is disease Treatment creates more preferable condition.Nutrient refers to provide energy to human body in food, participate in body composition and adjust physiology work( The chemical composition of energy.Nutrition necessary to human body is known as protein, lipid, carbohydrate, mineral matter, vitamin, water, dietary fiber Deng.
To achieve the above object, the present invention adopts the following technical scheme that：
First purpose of the present invention is to provide a kind of respiratory disease tailored version clinical nutrition formula, including such as the following group Point and its parts by weight：18-24 parts protein, 22-28 parts fat, 35-42 parts carbohydrate, 4.5-7.5 parts meals are fine Dimension, 0.7-1.5 parts macroelement, 0.01-0.04 parts trace element, 0.005-0.03 parts liposoluble vitamin, 0.1-0.2 part water Soluble vitamin, 0.05-1 part meals elite, 0.05-2 part integration of drinking and medicinal herbs composition, 0.3-3 part natural plants compounds and 0.005-2 part new resource foods.
In order to further optimize above-mentioned clinical nutrition formula, the technical measures that the present invention is taken also include：
Preferably, the protein be selected from PURE WHEY, soybean protein isolate, hydrolysis Isin glue collagen, whole milk powder, At least one of dried whole-egg, lactoferrin, bovine colostrum, amino acid, protein peptides；Wherein protein content is in whole milk powder 24wt%, fat content 34wt%, carbohydrate content 40wt%.
Wherein, the amino acid is selected from 1B-Pidolidone, Pidolidone, L-arginine, L-Trp, L- paddy At least one of glutamine, taurine, Valine, ILE, L-Leu；The protein peptides are selected from soy oligosaccharides At least one of peptide, wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide, laughable peptide, amino peptide, ovalbumin peptide.
It is highly preferred that the protein includes PURE WHEY, soybean protein isolate, whole milk powder, dried whole-egg, colostrum Powder, ocean fish oligopeptide, soybean oligopeptide, taurine.
Preferably, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structures At least one of fat, DHA, EPA, ARA, phosphatide, more specifically described fat include safflower seed oil, walnut oil, peanut oil, Soybean oil, Ah's glycerine, olive oil, tea oil, oil and fat of sacha inchi, olive oil, coconut oil, perilla herb oil, deep sea fish oil, cupu oil, palm Oil, butter, cream, lard, medium chain triglyceride, lecithin, Purple Perilla Seed Oil etc.；More preferably olive oil, soybean oil, coconut Oil, perilla herb oil, medium chain triglyceride.
Preferably, the carbohydrate is included in fructose, rock sugar, lactose, maltodextrin, tapioca, resistant starch At least two；More preferably maltodextrin, tapioca, rock sugar, lactose.
Preferably, in above-mentioned nutrient formulation, protein, fat, the productivity ratio of carbohydrate are 15~20：40~ 50：35~40.More preferably 17：45：38.
Preferably, in above-mentioned nutrient formulation, medium chain triglyceride accounts for total lipid content and is higher than 40wt%, more preferably higher than 50wt%.
Preferably, the dietary fiber include inulin, konjaku flour, galactooligosaccharide, FOS, oligoisomaltose, At least one of soybean polyoses, cyclodextrin, resistant dextrin, soybean fiber；It is highly preferred that the dietary fiber includes 3.5- 5.5 parts of water-soluble dietary fibers and 1~2 part of insoluble diedairy fiber, it includes soybean fiber.
Preferably, the macroelement is selected from calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, K-IAO, sodium citrate At least one of with magnesium gluconate.
Preferably, the trace element is selected from ferrous gluconate, KI, zinc gluconate, sodium selenite, glucose At least one of sour copper, chromium sulfate, manganese gluconate and sodium molybdate.
Preferably, the liposoluble vitamin is selected from vitamin A, beta carotene, vitamin D3, vitamin E, vitamin K1At least one of.
Preferably, the water soluble vitamin is selected from vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, at least one of pantothenic acid, folic acid, nicotinic acid, choline, inositol, biotin.
Preferably, the meals elite is selected from cereal, beans, potato class, greengrocery, Homonemeae, nut-seed class, fishes and shrimps At least one of class, poultry meat, fruits；The cereal is selected from rice meal, millet powder, black rice flour, coixlacrymajobi powder, corn At least one of powder, wheat germ powder, oatmeal, buckwheat；The beans is selected from peameal, mung bean flour, black bean powder, red bean At least one of powder, soy meal；The potato class is mainly made up of common yam rhizome powder；The Vegetable powder is selected from carrot meal, white radish powder, south At least one of melon powder, spinach powder, tomato meal, broccoli powder, balsam pear powder；The Homonemeae be selected from mushroom powder, Kelp Powder and At least one of white fungus powder；The nut-seed class is selected from least one of pumpkin seed powder and lotus nut starch；The fish and shrimp Selected from least one of salmon powder and cod meal；The poultry meat is selected from chicken meal, powdered beef, pork liver powder and pig kidney powder At least one of；The fruits in red date powder, longan powder, apple powder, cherry powder, citrus powder, pyrus nivalis powder at least It is a kind of；More preferably coixlacrymajobi powder, red bean powder, common yam rhizome powder, powdered beef.
Preferably, the natural plants compound is selected from l-cn, Glucosamine, FOS, lutein, plant At least one of sterol, lycopene, resveratrol, allicin；More preferably l-cn.
Preferably, the integration of drinking and medicinal herbs composition be selected from Poria cocos, lily, peppermint, radix glycyrrhizae, sealwort, Exocarpium Citri Rubrum, balloonflower root, Momordica grosvenori, At least one of purple perilla.
It is highly preferred that the parts by weight of each component are as follows in the integration of drinking and medicinal herbs composition：0~1 part of lily, peppermint 0~1 Part, 0~1 part of radix glycyrrhizae, 0~1 part of sealwort, 0~1 part of Exocarpium Citri Rubrum, 0~1 part of balloonflower root, 0~1 part of Momordica grosvenori, 0~1 part of purple perilla.
Preferably, the new resource food is selected from first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo Leaf flavones, CPP, avenabeta glucosan, Oligomeric manna sugar, stachyose, Rosa roxburghii, yeast beta-dextran, newborn mineral At least one of salt, pueraria root powder, Rosa roxburghii, xylo-oligosaccharide.
It is highly preferred that the new resource food is avenabeta glucosan.
Second object of the present invention is to provide a kind of preparation of above-mentioned respiratory disease tailored version clinical nutrition formula Method, it comprises the following steps：
Step 1) prepares fat powder, liposoluble vitamin powder and water soluble vitamin powder using micro-capsule embedding techniques End；
Step 2) prepares integration of drinking and medicinal herbs component powders using crushing, alcohol extracting, water extraction, spray drying and sifting step；
Step 3) is smart by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals China, natural plants compound and new resource food are prepared into the powder that particle diameter is 150~250 μm respectively, if desired Above-mentioned raw materials can be carried out in advance baking processing；
Step 4) is by step 1)~3) sterilize after the powder for preparing is well mixed it is standby；
The mixed powder of step 4) is prepared into nutrient powder, nutrition emulsion, capsule by step 5) according to conventional technical means At least one of agent, tablet, pill or oral liquid；
Wherein, step 1) -3) order can mutually change.
Finally, the present invention relates to a kind of product prepared by above-mentioned respiratory disease tailored version clinical nutrition formula, bag Include nutrient powder, nutrition emulsion, capsule, tablet, pill, oral liquid etc..
In above-mentioned preparation method, wherein, the raw material of the integration of drinking and medicinal herbs composition is crushed, alcohol extracting concentration, water extraction are dense Contracting, and concentrate is subjected to spray drying integration of drinking and medicinal herbs component powders are made；Wherein, the vitamin and fat are respectively by micro- Encapsulated processing is prepared into vitamin powder and fat powder.
Preferably, the preparation process of the integration of drinking and medicinal herbs component powders is as follows：Using pulverizer to predetermined weight number Raw material is crushed, and the raw material of crushing is placed in container, adds 3~5 times of 60~80% second that weight is raw material weight Alcohol, soaked, extracted 2 times, merged alcohol extract and be concentrated into no alcohol taste；After the active compound dregs of a decoction fling to ethanol, weight is added as original 6~8 times of water of material weight is soaked, and is carried out 30~60min of decoction to soak, is filtered off except raw material, leaves and takes decoction Liquid；Merge alcohol extract and decoction liquor after concentration, and it is spray-dried, it is same finally to prepare medicine food with 60~80 mesh sieves point Derived components powder.
Preferably, what the microencapsulation of the vitamin was handled comprises the following steps that：1) using liposoluble vitamin as core Material, from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, big Beans protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean fiber, lactose, rock sugar One or more in powder, emulsifying agent, stabilizer high-pressure homogeneous emulsification, are sprayed instantaneous dry, with 60~80 mesh sieves as wall material Divide and prepare liposoluble vitamin powder；2) using water soluble vitamin as core, from sodium carboxymethylcellulose, gelatin, OK a karaoke club Glue, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, chrysanthemum One or more works in powder, PURE WHEY, oligoisomaltose, soybean fiber, lactose, candy sugar powder, emulsifying agent, stabilizer For wall material, it is well mixed, sprays instantaneous dry, water soluble vitamin powder is prepared with 60~80 mesh sieves point.
Preferably, the specific implementation step of the fatty micro-capsule embedding techniques is as follows：By fat, emulsifying agent, wall material with Water mixed dissolution prepares emulsion；After above-mentioned emulsion is stirred, emulsifying homogeneous processing is carried out, it is dry then to carry out spraying Dry, screening prepares fat powder, and fat powder is compared with conventional grease, and its dispersiveness, water solubility, emulsibility, inoxidizability are all Improve a lot；Wherein, the emulsifying agent be selected from fatty acid glyceride (glyceride), methyl glycol fatty acid ester (propylene glycol ester), One in sorbitan aliphatic ester (sorbitan acid), sucrose fatty ester (sucrose ester), lecithin, monoglyceride, Tween 80 Kind is a variety of；The wall material is selected from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, fat egg In vain, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean One or more in fiber, lactose, candy sugar powder, emulsifying agent, stabilizer.
The present invention also provides a kind of preparation method of above-mentioned respiratory disease tailored version clinical nutrition formula, and it is wet method Technique, comprise the following steps：
Step 1) prepare the protein containing predetermined weight number, fat, carbohydrate, dietary fiber, macroelement, Trace element, vitamin, integration of drinking and medicinal herbs composition, the raw material of natural plants compound and new resource food, in scheduled volume In water, according to the physical behavior of raw material, added successively according to sequencing, be stirred while addition, raw material is made Mixed emulsion；
The mixed emulsion temperature that step 1) obtains is maintained at 40-50 DEG C by step 2), and adjustment homogenization pressure makes it protect all the time Hold between 10-18Mpa, emulsifying homogeneous is carried out to mixed emulsion, then placed emulsion in evaporator, with default technology Parameter is concentrated, and is sterilized at 85-88 DEG C, obtains concentrate；
The concentrate that step 2) obtains is spray-dried by step 3), is crossed 60~80 mesh sieves, is prepared into powder；Using upper State powder and be prepared at least one of nutrient powder, nutrition emulsion, capsule, tablet, pill or oral liquid.
In the present invention using include lily, peppermint, radix glycyrrhizae, sealwort, Exocarpium Citri Rubrum, balloonflower root, Momordica grosvenori, purple perilla integration of drinking and medicinal herbs into Point, there is the effect of enhancing immunity of organisms, anti-virus ability after mentioned component compatibility synergy, can effectively improve respiratory system disease Organism physiology, biochemistry and the immunologic function of patient.
Lily plays the role of significant phlegm-dispelling functions, calmness, antitoxic heart-soothing and sedative；Lily is rich in lymphatic temperament and vitamin, to skin Skin cell metabolism is beneficial；Lily contains a variety of alkaloids, there is prevention effect to leukopenia, can hemocytes increasing, it is right Cytopenia has therapeutic action after chemotherapy and radiation treatment；Lily can also promote and strengthen in vivo monocyte system and Phagocytic function, improve the humoral immunity ability of body.
Peppermint has antiviral, sterilization, analgesia, itching-relieving action；Main component menthol has very strong in Herba Menthae Haplocalycis volatile oil Choleretic effect；The anti-irritant effect of menthol causes tracheae to produce new secretion, and makes the mucus of stiff be easy to discharge, and dispels Phlegm acts on；Menthol, menthones have inhibitory action to isolated rabbit intestines, and have digestion promoting function；Total flavonoid in peppermint has Choleretic effect.
Licorice polysaccharide has antibechic, relievingd asthma, the pharmacological action such as lung preversation and respiratory pathogen, while also significantly inhibits Adjust lung tissue intercellular adhesion molecule and produce protective effect；Licoflavone can effectively suppress the generation of lung inflammation medium, With the pulmonary lesion such as pulmonary edema；There is good inhibitory action to NF-kB signal paths, the leather of effective prevention and treatment clinically Infection of the Lan Shi negative bacteriums to lung.
Sealwort can make the activity increase of mouse liver superoxide dismutase, decline myocardium lipofuscin content；And mouse can be made Erythrocyte membrane Na+, K+-ATP enzymatic activitys improve；Sealwort has hypotensive, hypoglycemic, reducing blood lipid, atherosclerosis, prolongs The slow effect such as aging and antibacterial, Siberian solomonseal rhizome polysaccharide have Immunestimulatory effect.
Exocarpium Citri Rubrum has obvious correction disorders of lipid metabolism, reduces cholesterolemia, triglyceride and beta Lipoprotein, softens blood Pipe, improve microcirculation, antiatherosclerosis, suppress platelet aggregation and reduce blood viscosity, be advantageous to blood circulation, accelerate The effect of removing and the excretion of lipid residual particles (waste)；Pummelo peel general flavone has obvious to chronic alcohol liver injury Protective effect, general flavone have obvious oxidation resistant effect；Orange volatile oil has gentle stimulation to intestines and stomach, is advantageous to The discharge of gastrointestinal pneumatosis, and the secretion of gastric juice can be promoted, help to digest；Volatile oil can also stimulate respiratory mucosa, make secretion Thing increases, and sputum dilution, is advantageous to discharge；There is significant antibechic, eliminating the phlegm, anti-inflammatory, bacteriostasis simultaneously.
Balloonflower root may promote respiratory tract mucilage secretion, the platycodin contained by it to oral cavity, throat, mucous membrane it is direct Stimulate, can increase to reflectivity bronchial mucosa hypersecretion, so that sputum dilutes, be easy to discharge, make so as to play eliminating the phlegm With；Contained saponin(e has stronger antitussive effect in balloonflower root, also strengthens anti-inflammatory and immunization, its anti-inflammatory intensity with A Si Forest form is seemingly；The water extract of balloonflower root can strengthen the phagocytic function of macrophage, strengthen the sterilizing power of neutrocyte, improve lysozyme Activity, there is prevention effect to stress ulcer.
PEARLITOL 25C in Momordica grosvenori has an antitussive action, and Momordica grosvenori is tatanic to intestinal tube caused by acetylcholine or barium chloride Contraction has antagonism, makes intestinal tube loose and spasmolysis；Also there is antagonism to intestinal tube relaxation caused by adrenaline, make intestinal tube Recover spontaneous activity.
Purple perilla decoction has the refrigeration function of mitigation；There is promotion digestive juice secretion, promote the effect of gastrointestinal peristalsis；Branch can be reduced Tracheae is secreted, and alleviates bronchial spasm；Its agent has inhibitory action to Escherichia coli, shigella dysenteriae, staphylococcus；Purple perilla can contract Short blood clotting time, blood plasma recalcification time and APFI.
Compared with prior art, the invention has the advantages that：
(1) various nutrients are supplemented general equilibrium of the present invention, while are added with enhancing immunity of organisms, antiviral energy The integration of drinking and medicinal herbs composition of the effect of power, antitussive and antiasthmatic, and effective effective substance is extracted using the method for water extraction alcohol extracting comprehensively, helping While helping the malaise symptoms for improving respiratory disease patient, each internal organs ability of conditioning respiratory disease patient is played, Strengthen the absorption of all kinds of nutriments.
(2) three big production capacity accountings are protein in nutrient formulation of the present invention：Fat：Carbohydrate=17:45:38.It is high Fat low-carb is beneficial to PFT, blood gas index, the respiratory muscle strength for improving COPD patient, shortens Mechanical ventilation time； Medium chain triglyceride accounts for total lipid content and is higher than 40wt%, and medium chain triglyceride can mitigate stomach and intestine burden, digest and assimilate more common Fatty (long chain fatty acids LCT) easily, is properly added medium chain fatty acid, can be that COPD patient is quickly energized to meet it to energy The demand of amount.
(3) 0.55 part of perilla herb oil of present invention addition, containing abundant polyunsaturated fatty acid, it increases the amount of n-3 aliphatic acid It can reduce internal arachidonic acid (AA) ratio, EPA ratios increase in immunocyte membrane phospholipid, so as to promote immune tune Section so that inflammation and dyscrasia are formed and reduced.The systemic inflammatory response that may occur for COPD patient, appropriate n-3 fat Acid is effective anti-inflammatory, mitigates the symptom of COPD patient.
(4) present invention strengthens taurine, and taurine has inherent anti-inflammatory and antioxidation, and can prevent injury of lungs enters one Step deteriorates and plays therapeutic action；Present invention addition addition broccoli elite, Caulis et Folium Brassicae capitatae have the work(of strengthening immune system Can, and can protect or repair airway epithelial cell.
(5) present invention prepares vitamin using micro-capsule embedding techniques, and vitamin is embedded in wall material, can prevent dimension from giving birth to Element is destroyed by macroelement, trace element, extends the holding time of vitamin；The present invention is prepared using micro-capsule embedding techniques Powdered oil so that powdered oil has preferable mobility, is easy to be well mixed with other powdered components；And use micro-capsule bag After burying technology, grease is embedded in wall material, so as to avoid the contact with air to strengthen inoxidizability, is protected so as to play The maximum effect of strong type grease.
(6) raw material of respiratory disease tailored version clinical nutrition formula of the present invention is advance in preparation process 150~250 μm of powder is prepared into, this make it that, when preparing finished product, each nutrition composition can be well mixed, guarantor unit's volume In each nutrition composition content it is essentially identical, while when preparing liquid type preparation, each nutrition composition can be fully dispersed and complete Fully dissolved prevents occurring solid precipitation in liquid into solvent, the effect of finished product product has been effectively ensured.
The present invention is by the way that from rational basal nutrient element, using the proportioning of general equilibrium, while addition has enhancing machine Body immunity, antiviral and anti-inflammatory power, the integration of drinking and medicinal herbs composition of antitussive and antiasthmatic, natural plants compound, new resource food etc. Specific nutrient, and adjust its proportioning and carry out compatibility synergy with basal nutrient element, supplementing respiratory disease patient comprehensively must The nutritional ingredient of palpus, and the nutrient formulation is easier to be absorbed by respiratory disease people digest, gives full play to its each component Effect, passive protective physical fitness is improved, certain effect is all achieved to nutritional status, respiratory function, the life quality for improving patient, More preferable condition is created for disease treatment.
Embodiment
The present invention provides a kind of respiratory disease tailored version clinical nutrition formula, it is characterised in that including following component And its parts by weight：18-24 parts protein, 22-28 parts fat, 35-42 parts carbohydrate, 4.5-7.5 parts dietary fiber, 0.7-1.5 parts macroelement, 0.01-0.04 parts trace element, 0.005-0.03 parts liposoluble vitamin, 0.1-0.2 parts are water-soluble Property vitamin, 0.05-1 part meals elite, 0.05-2 part integration of drinking and medicinal herbs composition, 0.3-3 part natural plants compounds and 0.005-2 part new resource foods.In the formula, dietary fiber is insoluble including 3.5-5.5 parts water-soluble dietary fiber, 1-2 parts Dietary fiber；Protein, fat, the productivity ratio of carbohydrate are 17：45：38；Medium chain triglyceride accounts for total lipid content height In 40wt%.
With reference to embodiment, the embodiment of the present invention is further described.Following examples are only used for more Add and clearly demonstrate technical scheme, and can not be limited the scope of the invention with this.
Embodiment 1
Respiratory disease tailored version clinical nutrition formula of the present invention includes PURE WHEY 9.09g, soybean point From albumen 7.27g, whole milk powder 21.8g, dried whole-egg 0.18g, bovine colostrum 0.1g, ocean fish oligopeptide 0.1g, soy oligosaccharides Peptide 0.1g, taurine 0.12g；Olive oil 2.36g, soybean oil 3.82g, coconut oil 2.36g, perilla herb oil 0.55g, medium chain triglyceride Three ester 9.73g；Maltodextrin 20.87g；Water-soluble dietary fiber 4.18g, soybean fiber 1.82g；Calcium in macroelement 0.514g, phosphorus 0.272g, potassium 0.106g, sodium 0.243g, magnesium 0.157g；Iron 0.011g, zinc 0.007g in trace element；Vitamin A 0.0005g, beta carotene 0.017g, vitamin D30.000001g, vitamin E 0.009g；Vitamin B10.001g, dimension Raw plain B20.001g, vitamin B60.001g, vitamin B120.0000017g, vitamin C 0.118g, pantothenic acid 0.003g, Folic acid 0.00026g, nicotinic acid 0.0164g；Coixlacrymajobi powder 0.1g, red bean powder 0.1g, common yam rhizome powder 0.1g, powdered beef 0.1g, broccoli Powder 0.1g, lily 0.1g, peppermint 0.1g, radix glycyrrhizae 0.1g, sealwort 0.1g, Exocarpium Citri Rubrum 0.1g, balloonflower root 0.1g, Momordica grosvenori 0.1g, purple perilla 0.1g, l-cn 0.636g, avenabeta glucosan 0.018g.
Embodiment 2
Respiratory disease tailored version clinical nutrition formula of the present invention includes PURE WHEY 9.09g, soybean point From albumen 7.27g, whole milk powder 21.8g, dried whole-egg 0.18g, bovine colostrum 0.1g, ocean fish oligopeptide 0.1g, soy oligosaccharides Peptide 0.1g, taurine 0.12g；Olive oil 1.36g, soybean oil 2.82g, coconut oil 1.36g, perilla herb oil 0.55g, medium chain triglyceride Three ester 6.73g；Maltodextrin 26.87g；Water-soluble dietary fiber 4.18g, soybean fiber 1.82g；Calcium in macroelement 0.514g, phosphorus 0.272g, potassium 0.106g, sodium 0.243g, magnesium 0.157g；Iron 0.011g, zinc 0.007g in trace element；Vitamin A 0.0005g, beta carotene 0.017g, vitamin D30.000001g, vitamin E 0.009g；Vitamin B10.001g, dimension Raw plain B20.001g, vitamin B60.001g, vitamin B120.0000017g, vitamin C 0.118g, pantothenic acid 0.003g, Folic acid 0.00026g, nicotinic acid 0.0164g；Coixlacrymajobi powder 0.1g, red bean powder 0.1g, common yam rhizome powder 0.1g, powdered beef 0.1g, broccoli Powder 0.1g, lily 0.1g, peppermint 0.1g, radix glycyrrhizae 0.1g, sealwort 0.1g, Exocarpium Citri Rubrum 0.1g, balloonflower root 0.1g, Momordica grosvenori 0.1g, purple perilla 0.1g, l-cn 0.636g, avenabeta glucosan 0.018g.
Embodiment 3
Respiratory disease tailored version clinical nutrition formula of the present invention includes PURE WHEY 9.09g, soybean point From albumen 7.27g, whole milk powder 21.8g, dried whole-egg 0.18g, bovine colostrum 0.1g, ocean fish oligopeptide 0.1g, soy oligosaccharides Peptide 0.1g, taurine 0.12g；Olive oil 1.36g, soybean oil 2.82g, coconut oil 1.36g, perilla herb oil 0.55g, medium chain triglyceride Three ester 6.73g；Maltodextrin 26.87g；Water-soluble dietary fiber 4.18g, soybean fiber 1.82g；Calcium in macroelement 0.514g, phosphorus 0.272g, potassium 0.106g, sodium 0.243g, magnesium 0.157g；Iron 0.011g, zinc 0.007g in trace element；Vitamin A 0.0005g, beta carotene 0.017g, vitamin D30.000001g, vitamin E 0.009g；Vitamin B10.001g, dimension Raw plain B20.001g, vitamin B60.001g, vitamin B120.0000017g, vitamin C 0.118g, pantothenic acid 0.003g, Folic acid 0.00026g, nicotinic acid 0.0164g；Coixlacrymajobi powder 0.1g, red bean powder 0.1g, common yam rhizome powder 0.1g, powdered beef 0.1g, broccoli Powder 0.1g, lily 0.01g, peppermint 0.01g, radix glycyrrhizae 0.01g, sealwort 0.01g, Exocarpium Citri Rubrum 0.01g, balloonflower root 0.01g, Momordica grosvenori 0.01g, purple perilla 0.01g, l-cn 0.636g, avenabeta glucosan 0.018g.
Embodiment 4
A kind of preparation method of the special clinical nutrition formula of respiratory disease as described in 1~embodiment of embodiment 3 is such as Under：
1) powdered oil (powder fat) is prepared：
A) the wall material aqueous solution is prepared：Take 8 grams of maltodextrin, 4 grams of soybean protein isolate, 11 grams of whole-fat milk powder, dietary fiber 2 Gram (resistant dextrin), 0.5 gram of inulin, 5 grams of PURE WHEY, 0.5 gram of oligoisomaltose, 1 gram of soybean fiber, Arabic gum 0.2 gram, 0.5 gram of lactose, 2 grams of candy sugar powder, 50 milliliters of water stirs and (has ready conditions and heat while stirring to 60 DEG C, kept for 30 points Room temperature is cooled to after clock).
B) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in (olive oil in 17.66 milliliters of greases monoglyceride 2.22 milliliters, 3.59 milliliters of soybean oil, 2.22 milliliters of coconut oil, 0.52 milliliter of perilla herb oil, 9.13 milliliters of medium chain triglyceride).
C) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in the wall material aqueous solution Tween 80.
D) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed.
E) after addition stabilizer agar takes 0.1 gram (total solid concentration is 0.2%) to enter mixed solution, it is settled to water 200 milliliters (total solid concentration be 25%), disperse 2 minutes at a high speed under 20000r/min.
F) homogenization pressure is 25MPa, homogeneous 3 times (every time 5 minutes), homogeneous emulsion is made.
G) obtained emulsion is spray-dried, EAT is 195 DEG C, and leaving air temp is 80 DEG C.Collect powder Grease (powder fat).
2) integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, the raw material of predetermined weight number is crushed using pulverizer, the raw material of crushing is placed in container In, 3~5 times of 60~80% ethanol that weight is raw material weight are added, is soaked, extracted 2 times, merges alcohol extract and concentrates To without alcohol taste；After the active compound dregs of a decoction fling to ethanol, add weight and soaked for 6~8 times of water of raw material weight, soak is entered Row decocts 30~60min, filters off except raw material, leaves and takes decoction liquor；Merge alcohol extract and decoction liquor after concentration, and it is carried out Spray drying, finally prepare integration of drinking and medicinal herbs component powders with 60~80 mesh sieves point；
3) vitamin powder is prepared：Using the liposoluble vitamin of predetermined weight number as core, from oligomeric different malt Sugar is used as wall material, carries out 2 emulsifying homogeneous processing under high pressure, the emulsifying homogeneous time is 10~15min, then carries out spraying wink When dry, point prepare liposoluble vitamin powder with 60~80 mesh sieves；Using the water soluble vitamin of predetermined weight number as core Material, from maltodextrin, oligoisomaltose as wall material, it is well mixed, sprays instantaneous dry, prepared with 60~80 mesh sieves point Water soluble vitamin powder；
4) by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals elite, Natural plants compound and new resource food are prepared into the powder that particle diameter is 150~250 μm respectively；(step 1) -4) order Can mutually it change)
5) by step 1) -4) prepare powder in the similar devices such as mixer be well mixed after sterilize it is standby；
6) according to conventional technical means by step 5) sterilize after powder be prepared into nutrient powder, nutrition emulsion, capsule, At least one of tablet, pill or oral liquid.
In step 6), optionally increase appropriate food thickening agent, food additives and related formulation auxiliary material. The food thickening agent is in guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum At least one, the food additives are Aspartame, flavoring essence spices, at least one of brown sugar；More preferably OK a karaoke club Glue, Arabic gum, guar gum, Aspartame, flavoring essence spices.
Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent from producing The danger of green powder blast.
According to described with the classifications such as powdery, graininess, capsule shape, tablet shape, beverage can be prepared into.
Embodiment 5
1) influence of nutrient formulation preparation prepared by the present invention to normal mouse weight；
The nutrient powder for taking the embodiment of the present invention 1~3 to prepare is tested, while sets comparative example 1, comparative example 2 and blank pair According to group, comparative example 1 is right using the nutrient powder for not adding taurine and medium chain triglyceride preparation in the nutrient formulation of embodiment 2 Ratio 2 is using the nutrient powder for not adding the preparation of integration of drinking and medicinal herbs composition in the nutrient formulation of embodiment 2, blank control group gavage physiology Salt solution.
SPF level BALB/C mices, male and female half and half, body weight 25-30g, every group 10.Filled daily according to 0.3g/10g dosage Stomach mouse, continuous 30 days.Fed to single cage during mouse stomach, determine it daily and take in appetite, claim 1 body weight within every 3 days, finally Each group increased weight is calculated, is shown in Table 1.15
Influence of the respiratory disease tailored version clinical nutrition formula of table 1 to mouse weight
Group First body weight/g Whole body weight/g Weightening/g
Embodiment 1 25.2 42.3 17.1
Embodiment 2 26.8 43.5 16.7
Embodiment 3 27.3 45.2 17.9
Comparative example 1 29.7 45.5 15.8
Comparative example 2 28.5 43.6 15.1
Control group 25.9 39.4 13.5
Through toxotest, rat its body weight, food-intake, liver function, renal function, blood, routine urinalysis and each histopathology are examined Look into discovery without exception.
From the above results, the nutrient formulation has no and significantly affected that it can maintain mouse to mouse weight growth Normal physiological function, harmful effect is not produced to the normal growth of mouse, that is, shows that nutrient formulation of the present invention has Maintain material needed for mouse normal growth.
2) therapeutic effect of nutrient formulation preparation prepared by the present invention to respiratory disease patient；
The nutrient powder prepared using the embodiment of the present invention 1~3 is tested, while sets comparative example 1, comparative example 2, comparative example 1 using nutrient powder prepared by taurine and medium chain triglyceride is not added in the nutrient formulation of embodiment 2, comparative example 2 is using real Apply the nutrient powder for not adding the preparation of integration of drinking and medicinal herbs composition in the nutrient formulation of example 2.
Selection respiratory disease patient (including chronic cough of deficiency lung, asthma, pulmonary tuberculosis etc.) 300,40~60 years old age, Above-mentioned patient is randomly divided into 5 groups, every group of 60 people, treated 2~3 months, embodiment 1~3 and comparative example 1~2 take above-mentioned system Standby nutrient powder, each 15g 1 day 3 times, take after postprandial half an hour, refuse to obey during experiment and treat respiratory system disease with any The medicine of disease.
Curative effect situation criterion：Recovery from illness：Subjective symptoms and clinical sign disappear, and abnormal physico-chemical examination index is recovered just Often；It is effective：Subjective symptoms and clinical sign largely disappear, and abnormal physico-chemical examination index is close to normally；Effectively：Subjective symptoms and Clinical sign partial disappearance, abnormal physico-chemical examination index make moderate progress；It is invalid：Subjective symptoms is not improved or aggravated, clinical Sign is not improved, and abnormal physico-chemical examination index is without improvement.
Its experimental result such as following table：
Group Case number Healing number Effective number Efficiently individual quantity Invalid number It is efficient
Embodiment 1 60 32 18 6 4 93.3%
Embodiment 2 60 29 22 4 5 91.7%
Embodiment 3 60 34 15 8 3 95.0%
Comparative example 1 60 28 18 6 8 86.7%
Comparative example 2 60 25 16 10 9 85.0%
As seen from the above table, 1~2 pair of embodiment 1~3, comparative example treatment respiratory disease are effective in cure, but present invention system The effect of standby nutrient formulation, is better than comparative example 1~2, and this shows that each component has collaboration in nutrient formulation prepared by the present invention Effect.
From above-described embodiment, various components are mutual in the special clinical nutrition formula of respiratory disease of the present invention It is engaged, reasonable, comprehensive nutritional support is provided for respiratory disease patient, to improve the body of respiratory disease patient State, at the same add with strengthen immunity of organisms, antiviral and anti-inflammatory power, antitussive and antiasthmatic integration of drinking and medicinal herbs composition, Natural plants compound, new resource food, passive protective physical fitness is improved, nutritional status, respiratory function, existence matter to improving patient Amount all achieves certain effect, and more preferable condition is created for disease treatment.
The specific embodiment of the present invention is described in detail above, but it is only used as example, and the present invention is not intended to limit In particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and to replace In generation, is also all among scope of the invention.Therefore, the impartial conversion made without departing from the spirit and scope of the invention and repair Change, all should be contained within the scope of the invention.

Claims (9)

1. a kind of respiratory disease tailored version clinical nutrition formula, it is characterised in that including following component and its parts by weight： 18-24 parts protein, 22-28 parts fat, 35-42 parts carbohydrate, 4.5-7.5 parts dietary fiber, 0.7-1.5 parts constant member Element, 0.01-0.04 parts trace element, 0.005-0.03 parts liposoluble vitamin, 0.1-0.2 parts water soluble vitamin, 0.05-1 Part meals elite, 0.05-2 part integration of drinking and medicinal herbs composition, 0.3-3 part natural plants compounds and 0.005-2 part new resource foods；
Wherein, the integration of drinking and medicinal herbs composition is in Poria cocos, lily, peppermint, radix glycyrrhizae, sealwort, Exocarpium Citri Rubrum, balloonflower root, Momordica grosvenori, purple perilla At least one；
Wherein, the dietary fiber includes 3.5-5.5 parts water-soluble dietary fiber, 1-2 part insoluble diedairy fibers.
A kind of 2. respiratory disease tailored version clinical nutrition formula according to claim 1, it is characterised in that the medicine Food is lily, peppermint, radix glycyrrhizae, sealwort, Exocarpium Citri Rubrum, balloonflower root, Momordica grosvenori, purple perilla with derived components.
A kind of 3. respiratory disease tailored version clinical nutrition formula according to claim 2, it is characterised in that the medicine Food is as follows with the parts by weight of derived components：0~1 part of lily, 0~1 part of peppermint, 0~1 part of radix glycyrrhizae, 0~1 part of sealwort, Exocarpium Citri Rubrum 0~1 Part, 0~1 part of balloonflower root, 0~1 part of Momordica grosvenori, 0~1 part of purple perilla.
A kind of 4. respiratory disease tailored version clinical nutrition formula according to claim 1, it is characterised in that the battalion Support in formula, protein, fat, the productivity ratio of carbohydrate are 15~20：40~50：35~40.More preferably 17：45： 38。
A kind of 5. respiratory disease tailored version clinical nutrition formula according to claim 1, it is characterised in that the battalion Support in formula, medium chain triglyceride accounts for total lipid content and is higher than 40wt%.
A kind of 6. respiratory disease tailored version clinical nutrition formula according to claim 1, it is characterised in that the day Right plant compound is selected from l-cn, Glucosamine, FOS, lutein, phytosterol, lycopene, white black false hellebore At least one of alcohol, allicin.
7. a kind of respiratory disease tailored version clinical nutrition formula according to claim 1, it is characterised in that described new Resource food is selected from first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo-leaves flavones, CPP, swallow Wheat beta glucan, Oligomeric manna sugar, stachyose, Rosa roxburghii, yeast beta-dextran, newborn mineral salt, pueraria root powder, Rosa roxburghii, xylo-oligosaccharide At least one of.
It is 8. a kind of such as the preparation side of respiratory disease tailored version clinical nutrition formula according to any one of claims 1 to 7 Method, it is characterised in that comprise the following steps：
The fat, liposoluble vitamin, water soluble vitamin of step (1) predetermined weight are respectively adopted micro-capsule embedding techniques and prepared simultaneously Cross 60~80 mesh sieves and powder is made；
The integration of drinking and medicinal herbs composition of step (2) predetermined weight is made up of crushing, alcohol extracting, water extraction, spray drying and 60-80 mesh sieves excessively Powder；
Remaining component of step (3) predetermined weight is prepared into the powder that particle diameter is 150~250 μm respectively；
The powder that step (4) prepares step (1)~(3) is sterilized standby after being well mixed；
Direct-edible pharmaceutical formulation is made in step (4) mixed powder by step (5)；
Wherein, the order of step (1)~(3) can be changed mutually；The pharmaceutical formulation include nutrient powder, nutrition emulsion, capsule, Tablet, pill, oral liquid.
9. according to the preparation method of respiratory disease tailored version clinical nutrition formula according to any one of claims 1 to 7, It is characterised in that it includes following steps：
Step 1) prepares the protein containing predetermined weight number and amino acid, nucleotides, fat, carbohydrate, meals are fine Dimension, macroelement, trace element, vitamin, integration of drinking and medicinal herbs composition, the raw material of natural plants compound and new resource food Powder, in the water of scheduled volume, according to the physical behavior of raw material, add according to sequencing, enter while addition successively Row stirring, the mixed emulsion of raw material is made；
The mixed emulsion that step 2) obtains step 1) carries out emulsifying homogeneous, concentrating sterilizing, obtains concentrate；
The concentrate that step 2) obtains is spray-dried by step 3), sieving, is prepared into powder, and above-mentioned powder is prepared into At least one of nutrient powder, nutrition emulsion, capsule, tablet, pill or oral liquid.
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CN109601878A (en) * 2018-08-07 2019-04-12 丽睿客信息科技（北京）有限公司 For protecting the nutraceutical of injury of lungs
CN109497514A (en) * 2018-10-23 2019-03-22 上海奥医生物医药科技有限公司 AIDS tailored version clinical nutrition formula and preparation method thereof
CN113712197A (en) * 2021-08-30 2021-11-30 健康元药业集团股份有限公司 Nutritional composition for respiratory diseases and preparation method thereof
CN114886112A (en) * 2022-05-13 2022-08-12 云南西草资源开发有限公司 Special medical formula food for respiratory system diseases

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