CN108618129A - Sarcopenia tailored version clinical nutrition formula and preparation method thereof - Google Patents

Sarcopenia tailored version clinical nutrition formula and preparation method thereof Download PDF

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Publication number
CN108618129A
CN108618129A CN201810444528.6A CN201810444528A CN108618129A CN 108618129 A CN108618129 A CN 108618129A CN 201810444528 A CN201810444528 A CN 201810444528A CN 108618129 A CN108618129 A CN 108618129A
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parts
powder
sarcopenia
vitamin
clinical nutrition
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尤俊
季敬东
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Shanghai Olympic Medical Biotechnology Co Ltd
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Shanghai Olympic Medical Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The present invention provides a kind of sarcopenia tailored version clinical nutrition formula, including following component and its parts by weight：18 30 parts of protein, 9 13 parts of fat, 40 52 parts of carbohydrate, 48 parts of dietary fibers, 0.6 1.2 parts of macroelements, 0.01 0.03 parts of trace elements, 0.005 0.02 parts of liposoluble vitamins, 0.005 0.20 parts of water soluble vitamins, 0.2 1 parts of diet essence, 0.07 4 parts of integration of drinking and medicinal herbs ingredients, 0.1 1 parts of natural plants compounds and 0.03 0.6 parts of new resource foods；The present invention also provides the preparation methods of above-mentioned clinical nutrition formula.The clinical nutrition formula of the present invention disclosure satisfy that the nutritional need of sarcopenia patient's general equilibrium, and can improve the body quality of sarcopenia patient, promote Myodynamia recovery and anathrepsis.

Description

Sarcopenia tailored version clinical nutrition formula and preparation method thereof
Technical field
The present invention relates to nutrient formulation field more particularly to a kind of sarcopenia tailored version clinical nutrition formula and Preparation method.
Background technology
Musculoskeletal system is keeping position, completion movement, is protecting the side such as important internal organs and organismic internal environment stable state Face plays an important role.Not only positioned adjacent, function are mutually auxiliary with bone for muscle, but also by nerve, endocrine, immune, battalion It supports, the systematicness adjusting of mechanical stimulation, and the Local Phase of endocrine between the two, paracrine and Mechanics of Machinery is mutually adjusted.In addition, There is also certain similar molecular signals to adjust access between bone and muscle, these molecular signals for adjusting access are expected to become dry Pre- common target.
With social population's aging, musculoskeletal disease has become important public health problem.Sarcopenia The incidence of (sarcopenia, abbreviation flesh lack disease), osteoporosis (osteoporosis) and fracture increases with age is increased, Flesh lacks disease and osteoporosis occurs being collectively referred to as " moving obstacle syndrome " (dysmobility syndrome) together, " living The main reason for dynamic disorders syndrome " can cause the elderly to be easy to fall and fracture, then disable as elderly population, is lethal it One.Compared with osteoporosis, flesh lacks disease and is just gradually taken seriously in the past 10 years, and is achieved in terms of basis and clinical research Impressive progress, external related association have promulgated that flesh lacks the clinical guidelines of disease in succession.
Sarcopenia is a kind of illness reduced characterized by skeletal muscle quality and skeletal muscle tension declines, and companion It is decreased obviously with patient's deformity and dead risk, quality of life.Epidemiological study shows that human skeletal muscle increases with the age Constantly decaying.It is reported that after general 50 years old, skeletal muscle amount reduces 1%~2% every year on average, and chronic muscular is lost within 60 years old or more Estimation 30% loses about 50% for 80 years old or more, and muscle reduces 30% by influence muscle normal function.The report in the U.S. and Europe Display suffers from muscle decaying disease person, accounts for 5%~13% in 60 years old~70 years old the elderly, 80 years old added above to 11%~52%.
It is to increase age relevant disease that flesh, which lacks disease, is the coefficient complex disease of environment and genetics factor, kinds of risks factor Its generation is participated in mechanism, the pathogenesis that flesh lacks disease is related to following many aspects：
Movement is reduced：It is the elderly's muscle mass and the principal element that intensity is lost to increase age relevant locomitivity to decline.It is long The decline of phase bed person's muscle strength will be earlier than the loss of muscle mass, and activity intensity deficiency causes muscular strength to decline, and muscle is powerless Mobility is set to further decrease again, final muscle mass and muscle strength decline.More research prompt the elderly carries out impedance Movement can dramatically increase muscle mass, muscle strength and muscle quality.
Neuro-muscular miopragia：The normal function of motor neuron is required to the survival of muscle fibre, lacks disease in flesh The loss of A-MN is key factor in pathogenesis, and research finds that 70 years old later motor neuron quantity of the elderly is aobvious It writes and reduces, A-MN is lost up to 50%, and lower limb function is significantly affected.Senectitude A-MN and moving cell number Amount substantially reduces the decrease for directly resulting in muscle coordination decline and muscle strength.In meat fiber quantity, to flesh of being grown up Meat the study found that I type and II fiber type content are only the half of young man in muscle at 90 years old.Senectitude, due to starlike Cell quantity and placing power decline, and cause II fiber type to decline than I fiber type more notable.Sternzellen is that muscle-derived is dry thin Born of the same parents can be activated in regenerative process, be divided into new muscle fibre and new sternzellen, but this regenerative process is damaged in reply When II fiber type imbalance and quantity will be caused to reduce, and the elderly's muscle more rapid wear and difficult repair.
Increase the variation of age associated hormone：The variation of insulin, estrogen, androgen, growth hormone and glucocorticoid etc. is joined Lack the morbidity of disease with flesh.When flesh lacks disease, fat increases in body and myocyte, this is related with insulin resistance.Experiment has proven to After aging myocyte receives insulin action, albumen generative capacity is substantially reduced.The morbidity that estrogen lacks flesh disease acts on presence Inconsistent evidence, some epidemiology and intervention study prompt estrogen can prevent the loss of muscle mass.It is random to 5 right According to the network analysis that clinical test carries out, 3 research shows that muscle strength increases after estrogen replacement therapy, but does not influence body Component distributing, one research shows that Tibolone increases quadriceps muscle of thigh and knee stretches muscular strength, and increases lean tissue mass's amount, reduces body fat Amount.One research to health, aging and body composition, after finding estrogen replacement therapy, quadriceps muscle of thigh cross sectional area is more Height, but it is unrelated with knee to stretch muscular strength.As it can be seen that estrogen mainly influences muscle strength, may not be most in flesh lacks disease morbidity Important factor.And male's testosterone levels decline 1% with increasing age every year, this plays an important role in male's flesh lacks disease morbidity.Very Mostly researches show that the low testosterone levels of elderly men and the decline of muscle mass, intensity and function are related, experiment in vitro also confirms that testis Ketone can promote to dose-dependant sternzellen quantity to increase, and be the major regulator of its function.In addition, the elderly's vitamin D lacks very universal, and multinomial research confirms that vitamin D deficiency is the risk factors that flesh lacks disease, and 1,25 pairs of hydroxyvitamin D water Pancake is low related to muscle mass, muscle strength, equilibrant force decline and fall risk increase.
Pro-inflammatory cell factor：Pro-inflammatory cell factor participates in the morbidity that the elderly's flesh lacks disease, and research is found Blood IL-6, TNF-α and c reactive protein level are related with muscle mass, muscle strength.The research prompt high level of Dutch elderly population IL-6 and c reactive protein make muscle mass and muscle strength risk of missing increase.These inflammatory reaction cell factors, which increase, causes flesh Meat tissue anabolism is unbalance, and Protein catabolism increases.It is that flesh lacks disease that the elderly's inflammatory reaction cell factor increases for a long time Important risk factor.
Muscle cell apoptosis：Muscle biopsy shows that the elderly's muscle cell apoptosis is significantly higher than young man, this is the base that flesh lacks disease This pathogenesis, muscle cell apoptosis and mitochondrial function are not normal and muscle mass loss is related.Research confirms that flesh lacks disease and mainly involves II type muscle fibre it is dead more easily by apoptosis pathway.Increase age, oxidative stress, low growth factor and braking etc. can completely Trigger Caspase dependences or non-dependent apoptotic signal access.
Inherent cause：Muscle strength, lower limb function and activity of daily living become between inherent cause can explain individual respectively Different 36%~65%, 57% and 34%.Whole-genome association (GWAS) data that flesh lacks disease are less, and 2009 to 1000 The GWAS that example affinity-less relation the white American carries out and lean tissue mass are analyzed, and find thyroid releasing hormone receptor (TRHR) monokaryon glycosides Sour polymorphism (SNP) rs16892496 and rs7832552 is related with lean tissue mass's variation.
Trophic factor：Have proven to the elderly's anabolism rate reduce by 30%, reduce actually with the elderly's nutrition, disease, The rare pass of activity, it is still only related with age is increased, it is still disputable.The elderly's malnutrition and protein insufficiency of intake can cause muscle to close At reduction, existing research confirms that amino acid and albumen supplement can directly facilitate muscle protein synthesis, prevents flesh and lacks disease, it is suitable to recommend Dietary protein intake be daily every kilogram of 1.0~1.2g of weight.
Flesh lacks disease and lacks special clinical manifestation, patient can behave as it is weak, be easy tumbles, difficulty in walking, gait it is slow, Four limbs are very thin and powerless etc., and diagnosis depends on the assessment etc. of muscular strength, muscular strength and flesh amount.
The controlling object that flesh lacks disease includes that all flesh lacks caused by disease crowd, including various diseases, drug and useless use etc. Flesh lacks disease and senile flesh lacks disease.Control measure includes kinesiatrics, alimentotheray and drug therapy.The benefit of kinesiatrics with It is related through the approach such as Antioxidation reaction alleviation cell ageing etc..Aerobic exercise and work against resistance can be reduced with age Muscle quality and muscle strength decline.Work against resistance is considered as best Non-medicine intervention a kind of to sarcopenia One of mode.Studies have shown that high intensity resistance, which tempers relatively low middle intensity resistance exercise, can more significantly improve flesh amount and muscular strength.But it is high Intensity work against resistance can increase the elderly's injury probability, and excessive movement can increase the risk of heart disease, or even cause sudden Extremely.
There is presently no disease is lacked as the drug of idicatio using flesh, some drugs of clinical treatment other diseases may make flesh Meat benefits, and then promotes and lack disease for flesh.Including synthesis parahormone, activated vitamin D, β adrenergic receptors agonist, Angiotensin converting enzyme inhibitor, the antibody of myostatin and activin receptor agonist etc..
Since there are heats and protein insufficiency of intake by most of the elderlys, it is therefore proposed that the elderly wants in daily life Keep balanced diet and sufficient nutrition.If subalimentation in diet, or when consuming factor excessively there are other, it would be considered as albumen Matter or amino acid nutrient supplementary therapy.Several researchs confirm that on the basis of enough nutrition, cooperation exercise therapy can increase flesh Amount and muscular strength.Sufficient albumen intake (1~1.2g/kgd) can also improve flesh amount and part muscle function.It is especially rich Lactalbumin containing essential amino acids such as leucines.Supplement essential amino acid may prevent the flesh amount caused by long-term bed and subtract It is few.
The incidence that flesh lacks disease is higher and higher, and several factors can cause or aggravate it to occur, development, between them mutually Effect, contact are close, and without clear line of demarcation, the wherein age is most important factor.Lack the prevention of disease for flesh, especially always Year property flesh lack the prevention of disease, it should carry out from many aspects, could cannot effectively reduce morbidity in this way for a certain independent factor Rate reduces tumble and the risk of bone fracture of gerontal patient.Wherein nutritional intervention is the effective way for preventing and treating the elderly's flesh and lacking disease One of diameter.
But at present other than kinesiatrics, corresponding drug therapy and nutrition treatment are few specifically for muscle decaying disease The product of patient.
Chinese patent CN201410402199.0 discloses a kind of muscle decaying syndrome full nutrition formula food, " disappears Middle residence is mended ", the marrow of the Traditional Chinese Medicine of " balanced tone " it is theoretical, using the Chinese medical extract essence of 4 kinds or more medicine-food two-purposes, short Peptide, a variety of probiotics are primary raw material, with amino acid, prebiotics, carbohydrate, multivitamin and minerals auxiliary material, are come Source meets the nutritional need of muscle decaying syndrome patient, and tonifying middle-Jiao and Qi, yang invigorating is nourishing liver and kidney, inducing resuscitation of having one's ideas straightened out, strong Muscles and bones, dispelling wind and removing obstruction in the meridians support myogenic and enhance human immunity.But gastrointestinal function can be impacted by drinking Chinese medicine for a long time, And the stomach of somebody is not appropriate for drinking Chinese medicine, may result in the symptoms such as Nausea and vomiting；And the full nutrition formula food is only Supplemented with basic nutrition, the symptom for not being directed to sarcopenia patient gives the supplement of special dietary.
Therefore, the nutritional need of sarcopenia patient's general equilibrium can either be met by developing, and can improve flesh The body quality of meat decaying syndrome patients, promotes Myodynamia recovery and anathrepsis, and helps to alleviate sarcopenia The tailored version clinical nutrition formulas of other symptoms be particularly important.
Invention content
The purpose of the present invention is to overcome the defects in the prior art, and it is clinical to provide a kind of sarcopenia tailored version Nutrient formulation and preparation method thereof can either meet the nutritional need of sarcopenia patient's general equilibrium, and can change The body quality of kind sarcopenia patient, promotes Myodynamia recovery and anathrepsis, promotes protein level of skeletal muscle synthesis, adjusts Skeletal muscle mitochondrial dysfunction, and help to alleviate the other symptoms of sarcopenia.
To achieve the above object, the present invention adopts the following technical scheme that：
The first purpose of the invention is to provide a kind of sarcopenia tailored version clinical nutrition formula, including it is as follows Component and its parts by weight：18-30 parts of protein, 9-13 parts of fat, 40-52 parts of carbohydrate, 4-8 parts of dietary fibers, 0.6-1.2 parts of macroelements, 0.01-0.03 parts of trace elements, 0.005-0.02 parts of liposoluble vitamins, 0.005-0.20 parts of water Soluble vitamin, 0.2-1 parts of diet essence, 0.07-4 parts of integration of drinking and medicinal herbs ingredients, 0.1-1 parts of natural plants compounds and 0.03-0.6 parts of new resource foods；
Wherein, the new resource food includes first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, the leaf of bamboo Flavones, casein phosphopeptide, beta-hydroxy-Beta-methyl calcium butyrate, avenabeta glucosan, yeast beta-dextran, newborn mineral salt, maca At least one of powder, Rosa roxburghii Tratt, xylo-oligosaccharide；
Wherein, in the nutrient formulation, protein：Fat：The productivity ratio of carbohydrate is 20~25：20~25：50 ~60.
In order to advanced optimize above-mentioned technical proposal, the technical measures that the present invention is taken further include：
Further, in the nutrient formulation, protein：Fat：The productivity ratio of carbohydrate is 20~22：20~ 23：50~55；Further, in the nutrient formulation, protein：Fat：The productivity ratio of carbohydrate is 22：23：55.
Further, the protein includes hydrolyzing lactoalbumin powder, soybean protein isolate, Isin glue collagen, whole milk At least one of powder, dried whole-egg, lactoferrin, colostrum, amino acid, protein peptides；Wherein, the amino acid includes that L- relies ammonia Acid-Pidolidone, Pidolidone, L-arginine, L-Trp, L-Glutamine, taurine, Valine, l-Isoleucine, At least one of L-Leu；The protein peptides include that soybean oligopeptide, wheat protein peptide, pupa albumen peptide, marine fish are low At least one of poly- Gly-His-Lys, laughable peptide, amino peptide, ovalbumin peptide.
Further, the protein includes 15-20 parts of hydrolyzing lactoalbumin；Further, the protein packet Include 18-19 parts of hydrolyzing lactoalbumin.
Further, the amino acid includes 4-8 parts of branched-chain amino acid；Further, the amino acid includes 5-6 The branched-chain amino acid of part.
Further, the parts by weight of leucine are 2-4 parts in the branched-chain amino acid；Further, the branch The parts by weight of leucine are 2-3 parts in chain amino acid.
Further, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structures At least one of fat, DHA, EPA, ARA, phosphatide.
Further, the carbohydrate includes fructose, rock sugar, lactose, maltodextrin, tapioca, resistant starch In at least two；Further, the carbohydrate includes maltodextrin and resistant starch.
Further, the dietary fiber includes inulin, konjaku flour, galactooligosaccharide, oligofructose, oligomeric different malt At least one of sugar, soybean polyoses, cyclodextrin, resistant dextrin, soybean fiber.
Further, in the dietary fiber weight ratio of water-soluble dietary fiber and insoluble diedairy fiber be 5~ 8：0.8~1.5.
Further, the macroelement includes calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, calcium carbonate, gluconic acid At least one of potassium, potassium chloride, sodium chloride, sodium citrate, magnesium gluconate, magnesium carbonate.
Further, the trace element includes ferrous gluconate, potassium iodide, zinc gluconate, sodium selenite, grape At least one of saccharic acid copper, copper sulphate, chromium sulfate, chromium chloride, manganese sulfate, manganese gluconate and sodium molybdate.
Further, the liposoluble vitamin includes vitamin A, beta carotene, vitamin D, vitamin E, vitamin K1At least one of；Further, the liposoluble vitamin includes vitamin D3, VitAVitE, β-carrot Element；Further, the parts by weight of vitamin D are 0.000001-0.000005 parts in the liposoluble vitamin；More into one The parts by weight on step ground, the vitamin D are 0.000001-0.000003 parts.
Further, the water soluble vitamin includes vitamin B1, vitamin B2, vitamin B6, vitamin B12, dimension life At least one of plain C, pantothenic acid, folic acid, niacin, choline, inositol, biotin.
Further, the diet essence includes cereal, beans, potato, greengrocery, Homonemeae, nut-seed class, fishes and shrimps At least one of class, poultry meat, fruits；Wherein, the cereal include rice meal, millet powder, black rice flour, coixlacrymajobi powder, At least one of corn flour, wheat germ powder, oatmeal, buckwheat, the beans include peameal, mung bean flour, black bean powder, At least one of red bean powder, soy meal, the potato are mainly made of common yam rhizome powder, and the Vegetable powder includes carrot meal, white trailing plants At least one of Bu Fen, pumpkin powder, spinach powder, tomato meal, broccoli powder, balsam pear powder, the Homonemeae include mushroom powder, sea At least one of band powder, white fungus powder, the nut-seed class is mainly made of pumpkin seed powder and lotus nut starch, the fish and shrimp packet Include at least one of salmon powder and cod meal, the poultry meat include in chicken meal, powdered beef and pig kidney powder at least One kind, the fruits include at least one of red date powder, longan powder, apple powder, cherry powder, citrus powder, pyrus nivalis powder.
Further, the parts by weight of the integration of drinking and medicinal herbs ingredient are 0.07-0.35 parts.
Further, the integration of drinking and medicinal herbs ingredient include Fermented Soybean, Poria cocos, raspberry, lily, matrimony vine, sealwort, peppermint, At least one of the membrane of a chicken's gizzard, the sophora bud, Radix Glycyrrhizae；Further, the integration of drinking and medicinal herbs ingredient include lily, it is matrimony vine, sealwort, thin Lotus, the membrane of a chicken's gizzard, the sophora bud, Radix Glycyrrhizae；Further, the parts by weight of each component are in the integration of drinking and medicinal herbs ingredient：Lily 0.01- 0.5 part, 0.01-0.5 parts of matrimony vine, 0.01-0.5 parts of sealwort, 0.01-0.5 parts of peppermint, 0.01-0.5 parts of the membrane of a chicken's gizzard, sophora bud 0.01- 0.5 part, 0.01-0.5 parts of Radix Glycyrrhizae；Further, the parts by weight of each component are in the integration of drinking and medicinal herbs ingredient：Lily 0.01-0.35 parts, 0.01-0.35 parts of matrimony vine, 0.01-0.35 parts of sealwort, 0.01-0.35 parts of peppermint, the membrane of a chicken's gizzard 0.01-0.35 Part, 0.01-0.35 parts of the sophora bud, 0.01-0.35 parts of Radix Glycyrrhizae；
Further, the natural plants compound includes l-cn, Glucosamine, oligofructose, lutein, plant At least one of object sterol, lycopene, resveratrol, allicin；Further, the natural plants compound is a left side Carnitine is revolved, the parts by weight of the l-cn are 0.5-1 parts.
Further, the parts by weight of the new resource food are 0.03-0.21 parts.
Further, the new resource food includes newborn mineral salt, avenabeta glucosan, beta-hydroxy-Beta-methyl calcium butyrate.
Further, the parts by weight of each component are in the new resource food：Newborn mineral salt 0.01-0.5 parts, oat β- 0.01-0.5 parts of glucan, beta-hydroxy -0.01-0.5 parts of Beta-methyl calcium butyrate；Further, each in the new resource food The parts by weight of component are：Newborn mineral salt 0.01-0.1 parts, 0.01-0.1 parts of avenabeta glucosan, beta-hydroxy-Beta-methyl butyric acid 0.01-0.1 parts of calcium.
Second object of the present invention is to provide a kind of system of above-mentioned sarcopenia tailored version clinical nutrition formula Preparation Method includes the following steps：
Step 1, fat powder is prepared；
Step 2, integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, it will The raw material of crushing is placed in container, and 3~8 times of the water that weight is raw material weight is added, carries out immersion 3~4 hours, then to leaching Bubble liquid carries out 30~60min of decoction, and filtering removal raw material is left and taken decoction liquor, is spray-dried to decoction liquor, with 60~80 mesh Screening prepares integration of drinking and medicinal herbs component powders；
Step 3, liposoluble vitamin powder and water soluble vitamin powder are prepared：By the fat-soluble dimension of predetermined weight number Raw element is used as core material, selects carragheen, Arabic gum as wall material, carries out 2 emulsifying homogeneous processing, emulsifying homogeneous under high pressure Time is 10~15min, then carries out instantaneous drying of spraying, liposoluble vitamin powder is prepared with 60~80 mesh screenings；It will be pre- The water soluble vitamin of parts by weight is determined as core material, is selected maltodextrin, lipoprotein as wall material, is uniformly mixed, sprays wink When dry, prepare water soluble vitamin powder with 60~80 mesh screenings；
Step 4, by the protein of predetermined weight and amino acid, carbohydrate, dietary fiber, trace element, diet essence China, natural plants compound and new resource food are prepared into the powder that grain size is 150~250 μm respectively；
Step 5, the powder obtained by step 1~4 is sequentially added into mixing machine and is uniformly mixed obtained formula mixture, passed through It is spare after sterilization processing；
Step 6, the formula mixture is prepared into nutrient powder, nutrition emulsion, capsule, tablet, pill or oral solution At least one of；
Wherein, the sequence of step 1~4 can be replaced mutually.
Further, fat powder is prepared in the step 1 to specifically comprise the following steps：
1) wall material aqueous solution is prepared：Take maltodextrin 8g, soybean protein isolate 4g, whole-fat milk powder 11g, dietary fiber 2g, Inulin 1.5g, hydrolyzing lactoalbumin powder 5g, oligoisomaltose 0.5g, Arabic gum 0.2g, cornstarch 0.5g, tapioca 2g, water 50mL are stirred evenly；
2) monoglyceride is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in 10.3mL mixed plant greases；Institute Mixed plant grease is stated by 0.6mL perilla herb oils, 2.6mL coconut oil, 4.2mL soybean oils, 2.6mL olive oil, 0.3mL medium chain triglycerides Three esters form；
3) Tween 80 is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in the wall material aqueous solution；
4) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed, obtains mixed solution；
5) (a concentration of 0.2%) of total solid is settled to after the mixed solution with water addition stabilizer agar 0.1g (a concentration of 25%) of total solid, high speed dispersion 2 minutes, obtains emulsion to 200mL under 20000r/min；
6) by the emulsion at homogenization pressure 25MPa, homogeneous 3 times 5 minutes every time, obtains homogeneous emulsion；
7) the homogeneous emulsion is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C, is collected To fat powder.
Further, optionally increase suitable food thickening agent and food additives in the step 6.Wherein, The food thickening agent includes guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum At least one of, the food additives include at least one of Aspartame, food flavor fragrance, brown sugar.More preferably For carragheen, Arabic gum, guar gum, Aspartame, food flavor fragrance.
Further, the operating procedure of the preparation method of above-mentioned muscle decaying sign tailored version clinical nutrition formula is both needed to lazy Property gas protection under carry out, used inert gas is nitrogen, argon gas, helium etc..It is carried out under the protection of inert gas Aforesaid operations step can prevent the danger of powder explosion.
In the present invention using include lily, peppermint, Radix Glycyrrhizae, matrimony vine, sealwort, the sophora bud, the membrane of a chicken's gizzard integration of drinking and medicinal herbs ingredient, on There is raising immunity, promotion body Nutrition and Metabolism, alleviation muscle cramp, the related oxygen of reduction muscle after stating components compatibility synergy The effect of changing stress damage, reducing blood pressure.
The immunity of human body can be improved in protein, amino acid and polysaccharide in lily, also containing there are many nutriments, such as mine Substance, vitamin etc., these substances can promote body Nutrition and Metabolism, make body fatigue resistance, hypoxia-bearing capability enhancing, while can be clear Except internal harmful substance, slow down aging；
Peppermint acrid flavour, it is cool in nature；Return lung, Liver Channel；Faint scent, which rises, to be dissipated；With wind-dispelling heat-dissipating, refresh oneself, throat, promoting eruption, Xie Yu The effect of, in addition peppermint also has the function of anti-inflammatory analgetic, can alleviate muscle cramp；
Radix Glycyrrhizae contains there are many chemical composition, predominantly glycyrrhizic acid, liquiritin, and glycyrrhizic acid has stronger increase human immunity Function, liquiritin have anti-oxidation function；
Chinese-wolfberry nutritive is abundant, is rich in polysaccharides, and polysaccharides is a kind of water-soluble polysaccharide, by arabinose, glucose, This 6 kinds of monosaccharide components compositions of galactolipin, mannose, xylose, rhamnose, have physiological activity, can enhance nospecific immunity Function improves disease resistance, inhibits tumour growth and cell mutation；Contain beta carotene, trace elements of selenium and vitamin E, tool There is powerful anti-oxidation function, helps to reduce the related oxidativestress damage of muscle；
Sealwort nourshing kidney moistening lung, invigorates the spleen and benefits qi, strengthening the bones and muscles, has the function of anti-oxidant, anti-aging；Its anti-oxidation efficacy has Help reduce the related oxidativestress damage of muscle, function of delaying senility helps to improve old man's body quality；
The sophora bud is rich in protein, and the rutin (rutin) contained by sophora flower is the dimension life with enhancing capillary resistance Element can enhance vessel wall elasticity, improve the toughness of capillary, have the function of reducing blood pressure；Sarcopenia can be made Adult body basal metabolic rate reduces, and then causes the complication such as diabetes B, obesity, dyslipidemia and hypertension, muscle decaying Syndrome patients supplement the generation that the sophora bud helps avoid hypertension；
The membrane of a chicken's gizzard can promote digestion function of stomach and intestine, have stronger promoting digestion and removing indigestion effect, and energy invigorating the spleen and stomach, can promote Absorption into patient to other nutrition compositions in the clinical nutrition formula of the present invention.
Using the new resources food for including newborn mineral salt, avenabeta glucosan, beta-hydroxy-Beta-methyl calcium butyrate in the present invention Product, synthesized with enhancing bone density, raising immunocompetence, promotion nutrient absorption, promotion protein after mentioned component compatibility synergy, The effect of mitigating chronic infection, promoting anathrepsis.
Newborn mineral salt has the function of that enhancing bone density, the elderly are occurring to also occur that it except sarcopenia His complication such as osteoporosis symptoms, newborn mineral salt help to alleviate the generation of the complication of sarcopenia；Study table Bright, newborn mineral salt can not only obtain the increase of bone density, but also in supplement milk calcium compared with other calcium sources (such as calcium acetate) After several years, bone density still sustainable growth, but supplement inorganic calcium bone density stop replenish the calcium after bone density increase can occur it is inverse Turn；Therefore, it is particularly important to supplement newborn mineral salt by the patient of osteoporosis symptoms；
Avenabeta glucosan has significant reducing blood lipid, hypoglycemic and raising immunocompetence, maintains intestine microenvironment Etc. functions, it can also accelerate to determine the immunocyte of crowd, reaction to bacterium infection and the position for controlling bacterium infection, make Infection restores as early as possible, and avenabeta glucosan cannot hydrolyze in small intestine, and the degradation and as bacterial fermentation in large intestine Substrate, fermentation generate short chain fatty acids, especially butyric acid, are beneficial to function of intestinal canal, mono- glucans of oats β can make mouse intestinal Rise in value with Bifidobacterium in excrement and Bacillus acidi lactici, and the quantity of Escherichia coli is made to reduce, therefore oat beta-glucan is also with changing Kind function of intestinal canal, promotes the increment of intestinal beneficial bacterium, and therefore, the clinical nutrition for being added to the present invention of avenabeta glucosan is matched Side, patient can promote the absorption of other nutrition compositions after taking；
Beta-hydroxy-Beta-methyl butyric acid (CaHMB) is a kind of leucine metabolism being widely used in body builder or sportsman Product, lacking disease for flesh has prevention and treatment；HMB is the precursor of cholesterol biosynthesis, in protection membrane structure, dimension It holds that Skeletal Muscle Cell is complete etc. to play an important role, the synthesis of protein can be promoted, the degradation of protein is reduced, subtract Light chronic infection, it is to decompose letter by upregulated protein matter composite signal access and down-regulation protein to promote anathrepsis, mechanism Number access two aspect promotes protein synthesis to slow down muscle breakdown.
The present invention is had the following technical effect that compared with prior art using above-mentioned technical proposal：
1) sarcopenia tailored version clinical nutrition formula of the invention uses 20~25：20~25：50~60 Protein：Fat：The energy supply ratio of carbohydrate provides balanced nutritional supplementation for patient.
2) 15-20 parts of hydrolyzing lactoalbumin is added, it, can according to the digestibility of different proteins and bioavilability difference Protein is divided into " fast albumen " and " slow albumen ", the characteristics of " fast albumen " is after digestion can be quickly in the form of amino acid Occur in blood, the characteristics of " slow albumen " is that the amino acid ramp-up rate in Post-prandial plasma is slower, and lactalbumin is typical case Fast albumen；Since the raised degree of amino acid and time are to solve the muscle of sarcopenia crowd to amino in blood plasma An important factor for sensitivity to acid reduces, therefore, " fast albumen " has very the elderly population with sarcopenia Important meaning.
3) 4-8 parts of branched-chain amino acid is added, branched-chain amino acid includes leucine, isoleucine, valine, the load as nitrogen Body, the required other amino acid of auxiliary synthesis；Branched-chain amino acid can stimulate the generation of insulin, and the main function of insulin is just It is to allow periphery blood glucose by muscle absorption and as energy source, while it also has and grows sharp in terms of promoting muscle growth The effect of element collaboration, preferably promotes muscle growth；Add clinical battalion of the branched-chain amino acid in the present invention of above-mentioned parts by weight It supports in formula, the muscle recovery of sarcopenia patient can be accelerated.
4) parts by weight of leucine are 2-4 parts in branched-chain amino acid, have the amino acid that studies have shown that leucine is strengthened mixed Old human protein synthesis level only can be promoted by closing object, and in contrast, increasing leucine intake to young man can't increase Strong muscle protein synthesis；Primary Study mechanism shows that leucine can be by activating the mould pa mycin target protein mTOR of mammal And eukaryon startup factor approach and carry out stimulates the protein synthesis as insulin secretagogue both modes；Add appropriate amino acid Function of the leucine other than synthetic proteins, the i.e. synthesis as signal stimulus albumen can be played；Add above-mentioned parts by weight Leucine in the present invention clinical nutrition formula in, the synthesis of the protein of sarcopenia patient can be accelerated, from And the synthesis of patient muscle's protein can be stimulated to the maximum extent, increase and keeps muscle quality.
5) vitamin D is added, vitamin D receptor (VDR) is distributed widely in each tissue of human body, and 1,25 (OH) 2D passes through It is combined with VDR and plays biological effect, so as to cause the synthesis of muscle protein, the Proliferation, Differentiation of skeletal muscle fibre and skeletal muscle The increase of the increase and quantity of II type muscle fibre volume；In addition, vitamin D can be combined with membrane receptor, activating can induce phospholipase C With the signal transduction pathway of map kinase, a large amount of calcium ions are made to enter cell to influence the contractile function of muscle, addition is above-mentioned heavy The vitamin D of number is measured in the clinical nutrition formula of the present invention, flesh can be effectively prevented and lack the occurrence and development of disease, and can show Writing improves the function of muscular strength and muscle.
The present invention by select rational proportion basal nutrient element, while add have improve immunocompetence, enhancing bone it is close, Promote nutrient absorption, mitigates chronic infection, promote anathrepsis, alleviate muscle cramp, reduce the related oxidative stress damage of muscle The special dietaries such as dietary fiber, diet essence, integration of drinking and medicinal herbs ingredient, natural plants compound, the new resource food of the effect of hindering Substance can either meet the nutritional need of sarcopenia patient's general equilibrium, and can improve sarcopenia The body quality of patient promotes Myodynamia recovery and anathrepsis, promotes protein level of skeletal muscle synthesis, adjusts skeletal muscle mitochondrial function Disorderly and humoral factor and cell factor change, and help to alleviate the other symptoms of sarcopenia.
Specific implementation mode
The present invention provides a kind of sarcopenia tailored version clinical nutrition formulas, which is characterized in that including as follows Component and its parts by weight：18-30 parts of protein, 9-13 parts of fat, 40-52 parts of carbohydrate, 4-8 parts of dietary fibers, 0.6-1.2 parts of macroelements, 0.01-0.03 parts of trace elements, 0.005-0.02 parts of liposoluble vitamins, 0.005-0.20 parts of water Soluble vitamin, 0.2-1 parts of diet essence, 0.07-4 parts of integration of drinking and medicinal herbs ingredients, 0.1-1 parts of natural plants compounds and 0.03-0.6 parts of new resource foods；Wherein, the new resource food include first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, Eucommia Bark male flower, bamboo-leaves flavones, casein phosphopeptide, beta-hydroxy-Beta-methyl calcium butyrate, avenabeta glucosan, yeast beta-dextran, At least one of newborn mineral salt, pueraria root powder, Rosa roxburghii Tratt, xylo-oligosaccharide；Wherein, in the nutrient formulation, protein：Fat：Carbon The productivity ratio of hydrate is 20~25：20~25：50~60.
The present invention is described in more detail below by specific embodiment, for a better understanding of the present invention, But following embodiments are not intended to limit the scope of the invention.
Embodiment 1
Sarcopenia tailored version clinical nutrition formula of the present invention include hydrolyzing lactoalbumin powder 18.1g, Branched-chain amino acid 5.45g, whole milk powder 4.54g, dried whole-egg 0.18g, Lyophilized Bovine Colostrums 0.18g, taurine 0.12g；Ocean Fish oligopeptide powder 0.09g, perilla herb oil 0.55g, coconut oil 2.36g, soybean oil 3.82g, olive oil 2.36g, medium chain triglyceride 0.29g；Maltodextrin 32.16g, resistant starch 12.73g；Water-soluble dietary fiber 6.18g, insoluble diedairy fiber 0.9g；Calcium 0.2g, phosphorus 0.21g, potassium 0.08g, sodium 0.02g, magnesium 0.15g；Iron 0.011g, iodine 0.00014g, zinc 0.007g；Vitamin A 0.0006g, beta carotene 0.000057g, vitamin D30.000003g, vitamin E 0.009g；Vitamin B1 0.001g、 Vitamin B20.001g, vitamin B60.001g, vitamin B120.000002g, vitamin C 0.15g, pantothenic acid 0.003g, Folic acid 0.000165g, niacin 0.0165g；Diet essence 1g；Lily 0.05g, peppermint 0.05g, Radix Glycyrrhizae 0.05g, matrimony vine 0.05g, Sealwort 0.05g, sophora bud 0.05g, the membrane of a chicken's gizzard 0.05g；L-cn 0.64g；Newborn mineral salt 0.09g, avenabeta glucosan 0.02g, beta-hydroxy-Beta-methyl calcium butyrate 0.1g；
Wherein, leucine 3g in the branched-chain amino acid.
Embodiment 2
Sarcopenia tailored version clinical nutrition formula of the present invention include hydrolyzing lactoalbumin powder 18.1g, Branched-chain amino acid 5.45g, whole milk powder 4.54g, dried whole-egg 0.18g, Lyophilized Bovine Colostrums 0.18g, taurine 0.12g；Ocean Fish oligopeptide powder 0.09g, perilla herb oil 0.55g, coconut oil 2.36g, soybean oil 3.82g, olive oil 2.36g, medium chain triglyceride 0.29g；Maltodextrin 32.16g, resistant starch 12.73g；Water-soluble dietary fiber 6.18g, insoluble diedairy fiber 0.9g；Calcium 0.2g, phosphorus 0.21g, potassium 0.08g, sodium 0.02g, magnesium 0.15g；Iron 0.011g, iodine 0.00014g, zinc 0.007g；Vitamin A 0.0006g, beta carotene 0.000057g, vitamin D30.000003g, vitamin E 0.009g；Vitamin B1 0.001g、 Vitamin B20.001g, vitamin B60.001g, vitamin B120.000002g, vitamin C 0.15g, pantothenic acid 0.003g, leaf Sour 0.000165g, niacin 0.0165g；Diet essence 1g；Lily 0.05g, peppermint 0.05g, Radix Glycyrrhizae 0.05g, matrimony vine 0.05g, Huang Smart 0.05g, sophora bud 0.05g, the membrane of a chicken's gizzard 0.05g；L-cn 0.64g；Casein phosphopeptide 0.09g, γ-aminobutyric acid 0.02g, beta-hydroxy-Beta-methyl calcium butyrate 0.1g；
Wherein, leucine 3g in the branched-chain amino acid.
Embodiment 3
Sarcopenia tailored version clinical nutrition formula of the present invention include hydrolyzing lactoalbumin powder 18.1g, Branched-chain amino acid 5.45g, whole milk powder 4.54g, dried whole-egg 0.18g, Lyophilized Bovine Colostrums 0.18g, taurine 0.01g, ocean Fish oligopeptide powder 0.09g；Perilla herb oil 0.55g, coconut oil 2.36g, soybean oil 3.82g, olive oil 2.36g, medium chain triglyceride 0.29g；Maltodextrin 32.16g, resistant starch 12.73g；Water-soluble dietary fiber 6.18g, insoluble diedairy fiber 0.9g；Calcium 0.2g, phosphorus 0.21g, potassium 0.08g, sodium 0.02g, magnesium 0.15g；Iron 0.011g, iodine 0.00014g, zinc 0.007g；Vitamin A 0.0006g, beta carotene 0.000057g, vitamin D30.000003g, vitamin E 0.009g；Vitamin B1 0.001g、 Vitamin B20.001g, vitamin B60.001g, vitamin B120.000002g, vitamin C 0.15g, pantothenic acid 0.003g, Folic acid 0.000165g, niacin 0.0165g；Diet essence 1g；Lily 0.05g, peppermint 0.05g, Radix Glycyrrhizae 0.05g, matrimony vine 0.05g, Sealwort 0.05g, sophora bud 0.05g, the membrane of a chicken's gizzard 0.05g；L-cn 0.64g；Newborn mineral salt 0.09g, avenabeta glucosan 0.02g, beta-hydroxy-Beta-methyl calcium butyrate 0.1g；
Wherein, leucine 2g in the branched-chain amino acid.
Embodiment 4
Sarcopenia tailored version clinical nutrition formula of the present invention include hydrolyzing lactoalbumin powder 18.1g, Branched-chain amino acid 5.45g, whole milk powder 4.54g, dried whole-egg 0.18g, Lyophilized Bovine Colostrums 0.18g, taurine 0.12g, ocean Fish oligopeptide powder 0.01g；Perilla herb oil 0.55g, coconut oil 2.36g, soybean oil 3.82g, olive oil 2.36g, medium chain triglyceride 0.29g；Maltodextrin 32.16g, resistant starch 12.73g；Water-soluble dietary fiber 6.18g, insoluble diedairy fiber 0.9g；Calcium 0.2g, phosphorus 0.21g, potassium 0.08g, sodium 0.02g, magnesium 0.15g；Iron 0.011g, iodine 0.00014g, zinc 0.007g；Vitamin A 0.0006g, beta carotene 0.000057g, vitamin D30.000003g, vitamin E 0.009g；Vitamin B1 0.001g、 Vitamin B20.001g, vitamin B60.001g, vitamin B120.000002g, vitamin C 0.15g, pantothenic acid 0.003g, leaf Sour 0.000165g, niacin 0.0165g；Diet essence 1g；Lily 0.01g, peppermint 0.01g, Radix Glycyrrhizae 0.01g, matrimony vine 0.01g, Huang Smart 0.01g, sophora bud 0.01g, the membrane of a chicken's gizzard 0.01g；L-cn 0.64g；Newborn mineral salt 0.09g, avenabeta glucosan 0.02g, Beta-hydroxy-Beta-methyl calcium butyrate 0.1g；
Wherein, leucine 2g in the branched-chain amino acid.
Embodiment 5
Sarcopenia tailored version clinical nutrition formula of the present invention include hydrolyzing lactoalbumin powder 18.1g, Branched-chain amino acid 5.45g, whole milk powder 4.54g, dried whole-egg 0.18g, Lyophilized Bovine Colostrums 0.18g, taurine 0.12g, ocean Fish oligopeptide powder 0.09g；Perilla herb oil 0.55g, coconut oil 2.36g, soybean oil 3.82g, olive oil 2.36g, medium chain triglyceride 0.29g；Maltodextrin 32.16g, resistant starch 12.73g；Water-soluble dietary fiber 6.18g, insoluble diedairy fiber 0.9g；Calcium 0.2g, phosphorus 0.21g, potassium 0.08g, sodium 0.02g, magnesium 0.15g；Iron 0.011g, iodine 0.00014g, zinc 0.007g；Vitamin A 0.0006g, beta carotene 0.000057g, vitamin D30.000001g, vitamin E 0.009g；Vitamin B1 0.001g、 Vitamin B20.001g, vitamin B60.001g, vitamin B120.000002g, vitamin C 0.15g, pantothenic acid 0.003g, leaf Sour 0.000165g, niacin 0.0165g；Diet essence 1g；Lily 0.01g, peppermint 0.01g, Radix Glycyrrhizae 0.01g, matrimony vine 0.01g, Huang Smart 0.01g, sophora bud 0.01g, the membrane of a chicken's gizzard 0.01g；L-cn 0.64g；Newborn mineral salt 0.01g, avenabeta glucosan 0.01g, Beta-hydroxy-Beta-methyl calcium butyrate 0.01g；
Wherein, leucine 4g in the branched-chain amino acid.
Embodiment 6
A kind of preparation side of sarcopenia tailored version clinical nutrition formula as described in 1~embodiment of embodiment 5 Method is as follows：
1) powdered oil (powder fat) is prepared：
A) wall material aqueous solution is prepared：Take maltodextrin 8g, soybean protein isolate 4g, whole-fat milk powder 11g, dietary fiber 2g (resistant dextrin), inulin 1.5g, hydrolyzing lactoalbumin powder 5g, oligoisomaltose 0.5g, Arabic gum 0.2g, cornstarch 0.5g, tapioca powder 2g, water 50mL, which are stirred evenly, (to have ready conditions and heats while stirring to 60 DEG C, keep 30 minutes postcoolings extremely Room temperature).
B) monoglyceride is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in 10.3mL mixed plant greases；It is mixed Vegetable fat is closed by 0.6mL perilla herb oils, 2.6mL coconut oil, 4.2mL soybean oils, 2.6mL olive oil, 0.3mL medium chain triglycerides Composition.
C) Tween 80 is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in wall material aqueous solution.
D) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed.
E) addition stabilizer agar takes 0.1g (a concentration of 0.2%) of total solid is settled to 200 into after mixed solution with water Milliliter (a concentration of 25%) of total solid, high speed dispersion 2 minutes under 20000r/min.
F) homogenization pressure is 25MPa, and homogeneous emulsion is made in homogeneous 3 times (every time 5 minutes).
G) emulsion obtained is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C.Collect powder Grease (powder fat).
2) integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, be added weight be raw material weight 3~8 times of water, immersion is carried out 3~4 hours, then to soak 30~60min of decoction is carried out, filtering removal raw material is left and taken decoction liquor, is spray-dried to decoction liquor, sieved with 60~80 mesh Prepare integration of drinking and medicinal herbs component powders；
3) vitamin powder is prepared：Using the liposoluble vitamin of predetermined weight number as core material, select carragheen, I Primary glue carries out 2 emulsifying homogeneous processing, the emulsifying homogeneous time is 10~15min, is then sprayed under high pressure as wall material It is instantaneous dry, prepare liposoluble vitamin powder with 60~80 mesh screenings；Using the water soluble vitamin of predetermined weight number as Core material is selected maltodextrin, lipoprotein as wall material, is uniformly mixed, and sprays instantaneous dry, is prepared with the screening of 60~80 mesh water-soluble Property vitamin powder；
4) by the protein of predetermined weight and amino acid, nucleotide, carbohydrate, dietary fiber, macroelement, micro Element, diet essence, natural plants compound and new resource food are prepared into the powder that grain size is 150~250 μm respectively；
5) mixing machine that the powder obtained by step 1)~step 4) is sequentially added to cone-type mixer or other forms is mixed Uniformly obtained formula mixture is closed, it is spare after sterilization processing；
6) according to conventional technical means by the formula mixture in step 5) be prepared into nutrient powder, nutrition emulsion, capsule, At least one of tablet, pill or oral solution.
In step 6), optionally increase suitable food thickening agent and food additives.The food thickening agent It is described at least one of guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum Food additives are at least one of Aspartame, food flavor fragrance, brown sugar；More preferable carragheen, Arabic gum, Guar Glue, Aspartame, food flavor fragrance.
Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent from producing The danger of green powder explosion.
According to described with the classifications such as powdery, graininess, capsule shape, tablet shape, beverage can be prepared into.
Embodiment 7
The present embodiment is verification embodiment.
This verification embodiment verifies sarcopenia tailored version clinical nutrition formula of the present invention and declines to muscle Subtract the influence of patient.Nutrient powder and following comparative example of the present embodiment using the formula preparation of Examples 1 and 2：
Control group：Using conventional nutrient powder；
Experimental group 1：The nutrient powder prepared using the nutrient formulation of embodiment 1；
Experimental group 2：The nutrient powder prepared using the nutrient formulation of embodiment 2；
Experimental group 3：The nutrient powder prepared using integration of drinking and medicinal herbs ingredient is deleted in the nutrient formulation of embodiment 1；
Experimental group 4：The nutrient powder prepared using new resource food is deleted in the nutrient formulation of embodiment 1；
Experimental group 5：The nutrient powder prepared using branched-chain amino acid is deleted in the nutrient formulation of embodiment 1；
The muscle decaying patient 20 of corresponding nutrient powder is voluntarily taken in every group of selection above, and the age distribution of selected patient is 50-60 Sui, male to female ratio 1:1；It is edible that above-mentioned nutrient powder is given during maintaining normal work against resistance and Aerobic Exercise Training；Often Day is sooner or later primary, takes after mixing it with water, and experimental result statistics is carried out after 2 months.
Experimental result is average value, and the experimental results are shown inthe following table：
Table one is that the variation of edible Patients Before And After muscle strength index is compared：
Grip is measured using the extra large electronic grip meter of remittance, in test process, is not allowed to crank arm when subject exerts oneself, is swung arm, bends over Or other positions of the hand domestic animal body of attachment means meter；
Back strength and leg muscular strength are measured using Nantong weighing apparatus factory BCS-400 electronics back dynamometers, in test process, the pull-up back of the body Power timing is picked, crook one's arm or body after fall.
Table one eats the variation (kg) of Patients Before And After muscle strength index
Table two is the measurement result of edible rear patient's muscle quality index：
Test method be using muscle quality test four methods measure (upper ladder endurance test method, upper terraced endurance test method, Muscular endurance method of testing and seat measurement of muscule strength dynamometry method), evaluation criterion is as follows：
0：Feeling relaxed after upper ladder；It can complete 30 times or more in 30 seconds and lie on the back to sit up；Finger tip can extend through forward foot Point；It can complete 30 times or more in 30 seconds and stand to sit down；
1：Feel relatively easily after upper ladder；It can complete 20-30 times in 30 seconds and lie on the back to sit up；Finger tip can encounter forward foot Point；It can complete 20-30 times in 30 seconds and stand to sit down；
2：Feel relatively painstaking after upper ladder；It can complete 10-20 times in 30 seconds and lie on the back to sit up；Finger tip can approach forward but Tiptoe cannot be encountered；It can complete 10-20 times in 30 seconds and stand to sit down；
3：Feel painstaking after upper ladder；It can complete 0-10 times in 30 seconds and lie on the back to sit up；Finger tip forwards, backwards from tiptoe have compared with Long a distance；It can complete 0-10 times in 30 seconds and stand to sit down.
The measurement result (n (%)) of patient's muscle quality index after table two is edible
As can be known from the above table, sarcopenia tailored version clinical nutrition formula of the present invention can be obviously improved trouble The muscle strength and muscle quality of person.It is not added with facing for integration of drinking and medicinal herbs ingredient of the invention, new resource food or branched-chain amino acid Bed nutrient formulation its effect is higher than the control group using conventional nutrient powder, but be slightly below added to the integration of drinking and medicinal herbs of the present invention at Point, the experimental group of the clinical nutrition formula of new resource food and branched-chain amino acid.Illustrate integration of drinking and medicinal herbs ingredient, new resource food or The components such as branched-chain amino acid are essential for the realization for improving sarcopenia effect, with other groups of the invention Divide and complement each other, gives full play to respective effect, excellent effect could be obtained.
By above-described embodiment it is found that sarcopenia tailored version clinical nutrition formula of the present invention can either expire The nutritional need of sufficient sarcopenia patient general equilibrium, and the body matter of sarcopenia patient can be improved Amount promotes Myodynamia recovery and anathrepsis, promotes protein level of skeletal muscle synthesis, adjusts skeletal muscle mitochondrial dysfunction, and help In the other symptoms for alleviating sarcopenia；Have to improve after the integration of drinking and medicinal herbs components compatibility synergy that the present invention uses and be immunized Power, the effect of promoting body Nutrition and Metabolism, alleviating muscle cramp, reduce the related oxidativestress damage of muscle, reduce blood pressure；This There is enhancing bone density after the new resource food compatibility synergy that invention uses, improve immunocompetence, promotion nutrient absorption, promote egg The effect of white matter synthesis, mitigation chronic infection, promotion anathrepsis.
Specific embodiments of the present invention are described in detail above, but it is intended only as example, the present invention is simultaneously unlimited It is formed on particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and It substitutes also all among scope of the invention.Therefore, without departing from the spirit and scope of the invention made by impartial conversion and Modification, all should be contained within the scope of the invention.

Claims (9)

1. a kind of sarcopenia tailored version clinical nutrition formula, which is characterized in that including following component and its parts by weight Number：18-30 parts of protein, 9-13 parts of fat, 40-52 parts of carbohydrate, 4-8 parts of dietary fibers, 0.6-1.2 parts of constant members Element, 0.01-0.03 parts of trace elements, 0.005-0.02 parts of liposoluble vitamins, 0.005-0.20 parts of water soluble vitamins, 0.2- 1 part of diet essence, 0.07-4 parts of integration of drinking and medicinal herbs ingredients, 0.1-1 parts of natural plants compounds and 0.03-0.6 portions of new resources foods Product；
Wherein, the new resource food include first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo-leaves flavones, Casein phosphopeptide, beta-hydroxy-Beta-methyl calcium butyrate, avenabeta glucosan, yeast beta-dextran, newborn mineral salt, pueraria root powder, thorn At least one of pears, xylo-oligosaccharide；
Wherein, in the nutrient formulation, protein：Fat：The productivity ratio of carbohydrate is 20~25：20~25：50~60.
2. sarcopenia tailored version clinical nutrition formula according to claim 1, which is characterized in that the albumen Matter includes 15-20 parts of hydrolyzing lactoalbumin.
3. sarcopenia tailored version clinical nutrition formula according to claim 1, which is characterized in that the albumen Matter includes amino acid, and the amino acid includes 4-8 parts of branched-chain amino acid.
4. sarcopenia tailored version clinical nutrition formula according to claim 3, which is characterized in that the branch The parts by weight of leucine are 2-4 parts in amino acid.
5. sarcopenia tailored version clinical nutrition formula according to claim 1, which is characterized in that the medicine food Parts by weight with derived components are 0.07-0.35 parts.
6. sarcopenia tailored version clinical nutrition formula according to claim 1, which is characterized in that the new money Source food includes newborn mineral salt, avenabeta glucosan, beta-hydroxy-Beta-methyl calcium butyrate.
7. sarcopenia tailored version clinical nutrition formula according to claim 1, which is characterized in that the new money The parts by weight of each component are in the food of source：Newborn mineral salt 0.01-0.5 parts, 0.01-0.5 parts of avenabeta glucosan, beta-hydroxy- 0.01-0.5 parts of Beta-methyl calcium butyrate.
8. the preparation side of the sarcopenia tailored version clinical nutrition formula according to any one of claim 1-7 Method, which is characterized in that include the following steps：
Step 1, fat powder is prepared；
Step 2, integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, be added weight be raw material weight 3~8 times of water, immersion is carried out 3~4 hours, then to soak 30~60min of decoction is carried out, filtering removal raw material is left and taken decoction liquor, is spray-dried to decoction liquor, sieved with 60~80 mesh Prepare integration of drinking and medicinal herbs component powders；
Step 3, liposoluble vitamin powder and water soluble vitamin powder are prepared：By the liposoluble vitamin of predetermined weight number It as core material, selects carragheen, Arabic gum as wall material, carries out 2 emulsifying homogeneous processing, emulsifying homogeneous time under high pressure For 10~15min, instantaneous drying of spraying then is carried out, liposoluble vitamin powder is prepared with 60~80 mesh screenings；By predetermined weight The water soluble vitamin of number is measured as core material, selects maltodextrin, lipoprotein as wall material, is uniformly mixed, spray instantaneous dry It is dry, prepare water soluble vitamin powder with 60~80 mesh screenings；
Step 4, by the protein of predetermined weight and amino acid, carbohydrate, dietary fiber, trace element, diet essence, day Right plant compound and new resource food are prepared into the powder that grain size is 150~250 μm respectively；
Step 5, the powder obtained by step 1~4 is sequentially added into mixing machine and is uniformly mixed obtained formula mixture, by sterilization It is spare after processing；
Step 6, the formula mixture is prepared into nutrient powder, nutrition emulsion, capsule, tablet, pill or oral solution It is at least one；
Wherein, the sequence of step 1~4 can be replaced mutually.
9. preparation method according to claim 8, which is characterized in that prepare fat powder in the step 1 and specifically include Following steps：
1) wall material aqueous solution is prepared：Take maltodextrin 8g, soybean protein isolate 4g, whole-fat milk powder 11g, dietary fiber 2g, inulin 1.5g, hydrolyzing lactoalbumin powder 5g, oligoisomaltose 0.5g, Arabic gum 0.2g, cornstarch 0.5g, tapioca 2g, Water 50mL is stirred evenly；
2) monoglyceride is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in 10.3mL mixed plant greases；It is described mixed Vegetable fat is closed by 0.6mL perilla herb oils, 2.6mL coconut oil, 4.2mL soybean oils, 2.6mL olive oil, 0.3mL medium chain triglycerides Composition；
3) Tween 80 is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in the wall material aqueous solution；
4) the mixed plant grease and the wall material aqueous solution of addition Over emulsfication agent Tween 80 that add Over emulsfication agent monoglyceride is abundant Mixing, obtains mixed solution；
5) (a concentration of 0.2%) of total solid is settled to 200mL to addition stabilizer agar 0.1g after the mixed solution with water (a concentration of 25%) of total solid, high speed dispersion 2 minutes, obtains emulsion under 20000r/min；
6) by the emulsion at homogenization pressure 25MPa, homogeneous 3 times 5 minutes every time, obtains homogeneous emulsion；
7) the homogeneous emulsion is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C, and collection obtains fat Fat powder.
CN201810444528.6A 2018-05-10 2018-05-10 Sarcopenia tailored version clinical nutrition formula and preparation method thereof Pending CN108618129A (en)

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