CN114680339A - Nutritional supplement for improving muscle attenuation and delaying senescence and application thereof - Google Patents

Nutritional supplement for improving muscle attenuation and delaying senescence and application thereof Download PDF

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CN114680339A
CN114680339A CN202210378872.6A CN202210378872A CN114680339A CN 114680339 A CN114680339 A CN 114680339A CN 202210378872 A CN202210378872 A CN 202210378872A CN 114680339 A CN114680339 A CN 114680339A
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vitamin
nutritional supplement
powder
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牛凯军
丁钢强
黄建
顾叶青
孟革
唐艳斌
陈頔
张庭婧
王雪娜
沈彬
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Tianneng Health Industry Group Co ltd
Tianjin Medical University
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Tianneng Health Industry Group Co ltd
Tianjin Medical University
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/29—Mineral substances, e.g. mineral oils or clays
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention provides a nutritional supplement for improving muscle attenuation and delaying senescence and application thereof, the nutritional supplement is designed aiming at the physiological characteristics and nutritional requirements of old people and is rich in protein components such as easily absorbed amino acids, peptides, high-quality protein and the like, and the nutritional supplement of various vitamins and mineral substances comprises a nutrient mixture, fermented pea protein peptide powder, corn oligopeptide powder, vitamin K2 and a soybean milk powder composition. The nutritional supplement provided by the invention can obviously improve the walking speed (important evaluation indexes of muscle function attenuation and aging) of the old, effectively improve the levels of serum 25(OH) D and albumin, reduce the concentration of serum hypersensitive C reactive protein, realize the reduction of the level of in vivo chronic inflammation, has an ideal effect of improving the muscle attenuation of the old, improve the independent living capacity and the living quality of the old, delay aging and prolong the health life.

Description

Nutritional supplement for improving muscle attenuation and delaying senescence and application thereof
Technical Field
The invention belongs to the technical field of biological medicines, and particularly relates to a nutritional supplement for improving muscle attenuation and delaying senescence of old people and application thereof.
Background
The deterioration of physical functions accompanying the increase of age seriously affects the quality of life of the elderly, and has become an important issue to cope with the social aging crisis. In order to implement the national innovation-driven development strategy, actively deal with the challenge brought by the aging of the population to the development of the economic society and promote the healthy aging, researchers should design the nutritional supplement for the old according to the physiological characteristics and nutritional requirements of the old so as to prevent the serious diseases such as the asthenia of the old and improve the life quality of the old. The related products appearing at present have unsatisfactory effects and poor pertinence.
Disclosure of Invention
In view of the above, the present invention provides a nutritional supplement for improving the physical functions of the elderly to solve the above problems. The nutritional supplement can obviously improve the walking speed (important evaluation indexes of muscle function attenuation and aging) of the old, effectively improve the levels of serum 25(OH) D and albumin, reduce the concentration of serum hypersensitive C reactive protein, has ideal effect of improving the muscle attenuation of the old, improves the independent living capacity and the living quality of the old, delays aging and prolongs the health life.
In order to achieve the purpose, the technical scheme of the invention is realized as follows:
a nutrient mixture comprises the following components in parts by weight: 0.18-0.35 part of vitamin mixture, 0.65-1.15 parts of mineral and 0.03-0.05 part of auxiliary material.
Further, the vitamin mixture comprises the following components in parts by weight: 0.004-0.008 parts of vitamin A3255(XHC), 0.006-0.009 parts of vitamin D100(XHC), 0.01-0.03 parts of vitamin E (50%), 0.001-0.003 parts of vitamin B1 (hydrochloric acid), 0.01-0.03 parts of vitamin B2 (10%), 0.04-0.08 parts of vitamin B6 (5%), 0.002-0.004 parts of vitamin B12 (0.1%), 0.1-0.15 parts of vitamin C, 0.008-0.012 parts of nicotinamide, 0.0015-0.003 parts of folic acid (10%), and 0.003-0.005 parts of biotin (1%).
Further, the mineral comprises the following components in parts by weight: 0.06-0.1 part of ferric pyrophosphate (11%), 0.008-0.012 part of zinc oxide, 0.015-0.02 part of sodium selenite (0.5%), and 0.6-1 part of tricalcium phosphate (superfine).
Further, the auxiliary material is maltodextrin.
Wherein vitamin A is a fat-soluble vitamin, organic compound, and has chemical formula of C20H30O is stable to heat, acid and alkali and is easily oxidized, and ultraviolet rays can promote the oxidative damage of the O. Vitamin A includes A1 and A2, A1 is retinol. Vitamin A2, 3-dehydroretinol, has a physiological activity of 40% of vitamin A1. Vitamin a has a wide range of important physiological functions in the human body, and in summary, mainly comprises visual sense, regulation of cell proliferation and differentiation, intercellular information exchange and immune response, and the deficiency of vitamin a causes physiological dysfunction and pathological changes. It can be used for strengthening food, dairy products and liquid food, and has functions of improving vision, cell differentiation and embryo development, and also has effects of immunity, taste, hearing, and appetite.
Vitamin D is a fat-soluble vitamin, a steroid compound, and 25- (OH) D is the predominant form of vitamin D present in the blood. Vitamin D mainly comprises vitamin D2 and vitamin D3, while vitamin D3 is most abundant in the body and plays an important physiological function. Vitamin D3 is converted in the liver to 25-hydroxyvitamin D3[25- (OH) D ]3]And subsequently converted to active 1, 25-dihydroxyvitamin D in the kidney3[1,25-(OH)2D3]。1,25-(OH)2D3Is the main active form of vitamin D in the body. Can promote the absorption of calcium and phosphorus by intestinal tract; mobilize bone calcium and promote the kidney to reabsorb calcium and phosphorus.
Vitamin E is a fat-soluble vitamin, which includes four tocopherols and four tocotrienols, and is an antioxidant. Vitamin E includes two classes of 8 compounds, namely, tocopherol and tocotrienol, namely, alpha, beta, gamma, delta tocopherol and alpha, beta, gamma, delta tocotrienol, and alpha-tocopherol is the most abundant and most active form of vitamin E distributed most widely in nature. Vitamin E has antioxidant effect. The activity of the tocotrienol is certain when the substituents are different, but the activity of the tocopherol is obviously reduced. Vitamin E has effects in resisting oxidation, resisting atherosclerosis, enhancing immunity, protecting nervous system and skeletal muscle, and improving embryonic development and reproduction.
Vitamin B1 was the first water-soluble vitamin purified by humans, chemically named 3- [ (4-amino-2-methyl-5-pyrimidinyl) -methyl ] -5-2-hydroxyethyl) -4-methylthiazolium chloride in the form of a white crystalline powder. It is slightly smelly, bitter in taste and deliquescent. Melting point 248 ℃, readily soluble in water, slightly soluble in ethanol, insoluble in ether and benzene. Vitamin B1 has effects in maintaining normal sugar metabolism and nerve conduction. The content of vitamin B1 in yeast is the most in nature. Can be synthesized from 2-methylfuran, vinyl nitrile and the like or synthesized from beta-ethoxyethyl propionate, ethyl formate and the like. The vitamin B1 can construct coenzyme and maintain normal metabolism in vivo; inhibiting cholinesterase activity, and promoting gastrointestinal motility; and has certain effect on nervous tissues.
Vitamin B2 is a water-soluble vitamin, but slightly soluble in water, with a solubility of 12mg/100mL at 27.5 ℃. Soluble in sodium chloride solution, easily soluble in dilute sodium hydroxide solution, easily soluble in alkaline solution, and stable in strong acid solution. Heat resistance and oxidation resistance. Light and uv radiation cause irreversible decomposition. The main physiological role of vitamin B2 is to promote metabolism as a coenzyme. Riboflavin is combined with phosphoric acid and a molecule of protein to form the flavoenzyme. This class of enzymes, also called dehydrogenases, is important for a very mediated transfer of hydrogen atoms important for the metabolism of sugars, lipids and amino acids. It is an essential factor for the growth of many animals and microorganisms. Participate in vivo biological oxidation and energy generation; FDA and FMN are involved in the conversion of tryptophan to nicotinic acid and vitamin B6 to pyridoxal phosphate as coenzymes, respectively; FDA is used as coenzyme of glutathione reductase, participates in an antioxidant defense system in vivo, and maintains the concentration of reduced glutathione; is involved in drug metabolism.
Vitamin B6 is colorless crystal, is easily soluble in water and ethanol, is stable in acid solution, is easily destroyed in alkaline solution, and has heat resistance to pyridoxine, pyridoxal and pyridoxamine. Vitamin B6 is rich in yeast, liver, grain, meat, fish, egg, bean and peanut. Vitamin B6 is a component of some coenzymes in human body, participates in various metabolic reactions, and especially has close relation with amino acid metabolism. Regulating immune function, reducing chronic diseases, improving nervous system, and participating in various metabolic processes, regulating lipid metabolism, regulating hormone, etc.
Vitamin B12 is a polycyclic compound containing 3-valent cobalt, with 4 reduced pyrrole rings linked together to become 1 corrin macrocycle (similar to porphyrin), the only metal-element-containing vitamin. The vitamin B12 is red crystal powder, has no smell and taste, is slightly soluble in water and ethanol, is most stable under the condition of pH 4.5-5.0 and weak acid, and can be decomposed in strong acid (pH <2) or alkaline solution to a certain extent when being heated. Higher animals and plants cannot produce vitamin B12, and vitamin B12 in nature is synthesized by microorganisms. Vitamin B12 is the only vitamin that needs the help of intestinal secretions (endogenous factors) to be absorbed, and is involved in the production of bone marrow red blood cells, prevention of pernicious anemia, and prevention of damage to the cerebral nerves. Can promote the biosynthesis of protein; protecting the transfer and storage of folic acid in cells.
Vitamin C is a polyhydroxy compound of the formula C6H8O6. The structure of the compound is similar to that of glucose, and two adjacent enol-type hydroxyl groups at the 2 nd and 3 rd positions in the molecule are easy to dissociate to release H +, so that the compound has the property of acid and is also called L-ascorbic acid. Vitamin C has strong reducibility and is easily oxidized into dehydrovitamin C, but the reaction is reversible, and ascorbic acid and dehydroascorbic acid have the same physiological function, but if the dehydroascorbic acid is further hydrolyzed to generate diketogulonic acid, the reaction is irreversible and the physiological effect is completely lost. Promoting collagen synthesis, neurotransmitter synthesis, detoxification, preventing cancer, scavenging free radicals, promoting antibody formation and iron absorption, etc.
Niacinamide is an amide compound of nicotinic acid. A crystalline powder that is white; no or almost no odor, bitter taste; it is slightly hygroscopic. It is soluble in water or ethanol, and soluble in glycerol. The traditional Chinese medicine composition is mainly used for preventing and treating pellagra, stomatitis, glossitis, sick sinus syndrome, atrioventricular block and the like in clinic. Promoting the processes of biological oxidation and tissue metabolism in vivo, protecting cardiovascular system, etc.
Folic acid is a water-soluble vitamin with the molecular formula of C19H19N7O6. The green leaf is named because it is rich in pteroylglutamic acid. There are several forms of parent compound which occur in nature and which are a combination of 3 components of pteridine, p-aminobenzoic acid and glutamic acid. Folic acid contains 1 or more glutamyl groups and most naturally occurring folic acid is in the form of polyglutamic acid. The biologically active form of folic acid is tetrahydrofolic acid. Folic acid is yellow crystals, slightly soluble in water, but its sodium salt is very soluble in water. Is insoluble in ethanol. It is easily destroyed in acid solution, unstable to heat, easily lost at room temperature, and easily destroyed by visible light. Has important effect on the synthesis of protein and nucleic acid and the metabolism of various amino acids.
Biotin is a water-soluble vitamin, also belonging to the B vitamin family, B7. It is an essential substance for the synthesis of vitamin C, an indispensable substance for the normal metabolism of fats and proteins. Is a nutrient necessary for maintaining the natural growth and development of human bodies and the normal function and health of human bodies. The content of the carbon dioxide in liver, kidney, yeast and cow milk is high, and the carbon dioxide is an important factor for fixing carbon dioxide by organisms. It is easy to combine with one of chicken proteins, and the absorption of biotin can be blocked by a large amount of edible raw protein, resulting in biotin deficiency. Form the photosensitive material in visual cells, maintain the integrity and the soundness of epithelial tissue structure, enhance the immune response and the resistance of organisms, maintain normal growth and development, and can be used for treating arteriosclerosis, apoplexy, lipid metabolism disorder, hypertension, coronary heart disease and blood circulation disorder diseases.
Ferric pyrophosphate is an inorganic salt with a molecular formula of Fe4(O7P2)3. Is yellow to brown powder, and has no odor and slight iron taste. The solution was a white to pale yellow emulsion. Obtained by reacting ferric chloride solution with sodium pyrophosphate solution. Can be used as food nutrition supplement (iron fortifier) for fortifying milk powder.
Zinc oxide is an inorganic substance, has a chemical formula of ZnO, and is an oxide of zinc. Is insoluble in water and soluble in acid and strong base. Zinc oxide in food mainly acts as an additive, and zinc is an essential element for human body.
Sodium selenite is an inorganic substance with chemical formula of Na2SeO3White crystals or crystalline powders. Can be used as selenium nutrition enhancer. Selenium is a component of glutathione peroxidase, and maintains the function of cell membranes through oxidation, increasing the yield of endogenous antioxidants of the lipidic nature of proteins. Participates in energy conversion, influences metabolism, and plays an extremely important role in fat emulsification and absorption and multivitamin absorption. Meanwhile, the enzyme also participates in the synthesis of coenzyme A and coenzyme Q, and influences the functions of other biological enzyme systems. Has effects on amino acid metabolism, protein synthesis, carbohydrate metabolism, and biological oxidation.
Tricalcium phosphate is a safe nutrient supplement, is mainly added into food to strengthen the intake of calcium, and can also be used for preventing or treating the symptoms of calcium deficiency.
The maltodextrin is prepared by using various starches as raw materials, and performing low-degree controlled hydrolytic conversion, purification and drying through an enzymatic process. The raw materials are corn containing starch, rice and the like. Or refined starch such as corn starch, wheat starch, tapioca starch, etc. Maltodextrin is widely used in candy, malted milk, fruit tea, milk powder, ice cream, beverage, can and other food, and is a filling material and a blending agent for various foods. Has the characteristics of high paste viscosity, good solubility, strong thickening stability and the like, and has good intersolubility with animal glue or other vegetable glue and better combined effect.
The nutrient mixture is a mixture of the above vitamins and minerals, and the proportion of each nutrient is properly prepared according to the required amount of the old, so that the requirements of the old on the vitamins and minerals can be met, and the nutrient mixture can be independently used.
A nutritional supplement for improving muscle attenuation and delaying aging comprises the nutrient mixture, fermented pea protein peptide powder, corn oligopeptide powder, vitamin K2(1000ppm) and soybean milk powder composition.
Further, by weight, 1-1.5 parts of nutrient mixture, 0.5-1.5 parts of fermented pea protein peptide powder, 0.5-1.5 parts of corn oligopeptide powder, 0.004-0.08 part of vitamin K2(1000ppm) and 7.8-11.8 parts of soybean milk powder composition.
The fermented pea protein peptide powder is prepared by extruding and crushing pea protein powder, adding an enzyme promoter and neutral protease into the extruded pea protein powder together, and performing enzymolysis on the pea protein powder to prepare the pea protein peptide powder. The pea peptide contains 8 amino acids which can not be synthesized by human body, and has various physiological activities and functions. Researches show that pea protein polypeptide can inhibit the activity of calmodulin-dependent protein kinase to influence calcium absorption, and researches also show that the effective inhibiting component peptide of angiotensin converting enzyme can be extracted from pea peptide; the pea peptide can effectively eliminate DPPH free radicals and OH free radicals, thereby having oxidation resistance. In addition, the pea peptide also has the positive effects of lowering blood pressure, reducing blood fat, reducing cholesterol, resisting cancer, resisting fatigue, resisting aging and the like on a human body, and mainly can help to improve immunity, regulate intestines and stomach, comprehensively supplement amino acid and promote collagen synthesis. The research also finds that the compound can relieve the effects of insulin resistance and the like to a certain extent.
The corn oligopeptide powder is produced by using corn protein powder as a raw material and carrying out processes such as size mixing, protease enzymolysis, separation, filtration, spray drying and the like. The corn oligopeptide powder is a new resource product, is a mixture of various small peptides obtained by degrading corn protein through enzyme, has excellent characteristics of peptide substances, and has the functions of direct absorption superior to amino acid or protein, strong solubility (completely soluble in water under a large pH value range, no turbidity and precipitate generation), strong stability (stable to heat, unchanged components and functions), high safety (natural food protein, safety, reliability, no toxic or side effect) and the like. The antioxidant capacity is one of the important activities of the corn peptide, which is probably because the corn peptide contains certain specific amino acids with free radical scavenging and reducing capacity, such as lysine, tyrosine, phenylalanine, proline and the like, and in vitro researches show that the small-molecule corn peptide can obviously inhibit the peroxidation of cell and tissue fat, can enhance the level of reduced glutathione peroxidase, has strong scavenging effect on superoxide anion free radicals and hydroxyl free radicals, and has correlation between the capacity of scavenging superoxide anions and the capacity of scavenging hydroxyl free radicals. The corn active peptide also has the function of reducing blood pressure, and scientific researches have found that the corn oligopeptide contains a large amount of antihypertensive peptides. These peptides exert a blood pressure lowering effect by decreasing the activity of angiotensin converting enzyme in the human body. In addition, it also has physiological functions of resisting fatigue, reducing cholesterol, promoting alcohol metabolism, etc.; the corn oligopeptide has more obvious advantages, can be absorbed without gastrointestinal digestion or only needs slight digestion, has obvious advantages on gastrointestinal tract digestive function reduction of old people, has good water solubility and stability, contains a large amount of glutamic acid, and has the function of maintaining and promoting brain cell functions.
Vitamin K2 is a general name of a series of terpene side chain compounds containing 2-methyl-1, 4-naphthoquinone mother nucleus and a plurality of isoprene structural units with different numbers at C3 position, vitamin K2 is the only bioactive form of vitamin K, and is mainly used for accelerating blood coagulation, maintaining blood coagulation time and treating hemorrhage caused by vitamin K deficiency.
Further, the soymilk powder composition comprises 3.5-4.0 parts of instant soybean powder, 3.0-4.0 parts of full cream milk powder, 0.2-0.6 part of dietary fiber, 0.05-0.1 part of konjac flour, 0.01-0.04 part of momordica grosvenori powder, 0.25-0.75 part of sodium caseinate, 0.05-0.15 part of sodium hexametaphosphate, 0.025-0.075 part of trisodium phosphate, 0.05-0.10 part of tricalcium phosphate, 0.1-0.2 part of thickening agent, 0.025-0.075 part of pH regulator, 0.03-0.1 part of essence and 0.5-1.5 parts of sweetening agent.
Further, the dietary fiber is resistant dextrin; the thickening agent is at least one of xanthan gum and carrageenan; the pH regulator is sodium bicarbonate; the essence is at least one of wheat essence and milk essence; the sweetener is at least one of xylitol and stevioside.
The instant soybean powder is one of double proteins due to the characteristics of quick dissolution, easy dissolution and the like, and the instant soybean powder contains rich and high-quality vegetable protein and grease and does not contain cholesterol. It can rapidly increase the protein content; the fat in the bean powder is mainly vegetable fat, and the content of unsaturated fatty acid is high; the bean flour contains abundant dietary fiber, and can improve dyspepsia of the elderly. Has effects in reducing blood fat, reducing weight, resisting blood coagulation, resisting oxidation, resisting cancer, and regulating immunity.
The whole milk powder provides high-quality animal protein, the protein content is not lower than 24%, the whole milk powder is used as fast protein, contains 8 kinds of amino acids essential for human body, is close to the requirement of human body, has good absorption efficiency, and is matched with instant soybean powder to improve the absorption of double proteins.
The resistant dextrin is used as soluble dietary fiber formed by partial degradation and glycosylation transfer of starch, has the advantages of heat resistance, acid resistance, freezing resistance, low browning and storage resistance, does not change the quality of food when added into the food, and also has the functions of reducing blood sugar and regulating intestinal tracts. Can be added into dairy product to partially replace granulated sugar or fat and enhance dietary fiber content.
The konjac glucomannan in the konjac flour is the main nutritional ingredient of the konjac flour, and has the effects of regulating glucose metabolism and preventing and treating diabetes; regulating lipid metabolism, and preventing and treating coronary heart disease; inhibiting obesity in human body; regulating gastrointestinal tract, and preventing constipation; improving immunity, and preventing cancer.
The fructus Siraitiae Grosvenorii powder contains multiple nutrients and bioactive factors, including vitamins, trace elements, essential amino acids, flavone, polysaccharide and sweet glycoside. The momordica grosvenori can inhibit bacteria, diminish inflammation, resist tumors, regulate the immune system, prevent chronic diseases such as cardiovascular and cerebrovascular diseases and the like, can also obviously intervene abnormal glycolipid metabolism, and is widely used as a functional sweetener in the fields of foods, functional foods and special medicine foods at present. The nutritive value of the momordica grosvenori mainly comprises a medical value and a dietotherapy value. The medicinal value mainly has the effects of moistening the lung, relieving cough and constipation, and simultaneously has the novel pharmaceutical effects of enhancing resistance, resisting oxidation, protecting the liver, preventing cariogenic and the like.
Sodium caseinate is used as a food additive, can play roles of emulsification, stabilization and protein fortifier, is also a thickening agent, and is widely applied to food.
The sodium hexametaphosphate is used as a food quality modifier to protect the color and luster of the food and has uniform texture.
Trisodium phosphate is used as an emulsifier, a nutritional supplement, a quality improver in food processing. As a sodium supplement, maintain normotensive blood pressure and enhance neuromuscular excitability.
Tricalcium phosphate is a safe nutrition enhancer, is mainly added into food to enhance the intake of calcium, and can also be used for preventing or treating the symptoms of calcium deficiency; and secondly, the compound is widely applied to milk powder as a glidant.
Xanthan gum has the effect of thickening dairy products, maintaining consistency and fluidity of food appearance. The latest research finds that the xanthan gum thickener is not easy to disperse food, thereby reducing swallowing difficulty and aspiration rate, and has the function of improving swallowing function for the elderly patients with swallowing disorder.
The carrageenan and the xanthan gum play a synergistic role simultaneously, and the elasticity and the water retention of the gel are improved simultaneously.
The sodium bicarbonate can regulate the overall pH value of the formula, neutralize gastric acid, dissolve mucus, reduce the viscosity of digestive juice, strengthen the contraction of stomach and intestine, and play roles in invigorating stomach, inhibiting acid and stimulating appetite.
The wheat flavor essence is a novel flavoring agent and has strong and natural wheat flavor. The product is used in beverage, cake, bread and other products, and has the function of promoting the product fusion with milk fragrance together, and has strong appetite and comfortable sensory feeling.
The milk essence can enhance the milk flavor of the milk powder and adjust the palatability of the product.
Xylitol not only can be used as a sweetening agent and an auxiliary therapeutic agent for diabetics, but also has the following effects: preventing dental caries, preventing respiratory tract infection, preventing hyperostosis, resisting oxidation, stabilizing insulin, and regulating intestinal flora.
Stevioside is a glycoside extracted from the leaves of stevia rebaudiana Bertoni of Compositae. Stevia rebaudiana is native to paraguay and brazil, and has the characteristics of high sweetness and low heat energy, the sweetness of the stevia rebaudiana is 200-300 times that of cane sugar, the calorific value is only 1/300 of cane sugar, the stevia rebaudiana is stable in acid and salt solution, and the stevia rebaudiana is stable in nature at room temperature. Is easily dissolved in water, can quickly absorb moisture in the air, and has the solubility of over 40 percent at room temperature. Stevioside is used together with citric acid or glycine, so that the taste is good; it can be mixed with sucrose, fructose, and other sweeteners to obtain good taste. The product is not absorbed after being eaten, does not generate heat energy, and is a good natural sweetener for patients with diabetes and obesity.
The soymilk powder composition can also be the existing commercial finished soymilk powder.
The invention also provides the application of the nutritional supplement in the preparation of health products for improving the body functions of the old, the blood biochemical indexes and/or sarcopenia of the old.
Preferably, the function of improving the body function of the elderly is to improve the walking speed of the elderly.
Preferably, the biochemical index for improving the blood of the elderly people is the improvement of the 25(OH) D level and/or the serum albumin level of the elderly people.
Preferably, the sarcopenia is improved by increasing the concentration of vitamin D and albumin and reducing the concentration of serum hypersensitive C-reactive protein.
Among them, vitamin DVD affects the proliferation, differentiation, protein synthesis and contractile function of cells through 2 regulation modes of its receptor-mediated transcription factor activity and non-transcription factor activity: in one aspect, active vitamin D causes myoblast proliferation, differentiation and protein synthesis by binding to its receptor; on the other hand, active vitamin D releases calcium into the cytoplasm by activating cellular second messenger cyclic amp, diacylglycerol, inositol triphosphate, arachidonic acid or by activating protein kinase C, and activates calcium endoplasmic reticulum transport by Ca2+ atpase to increase calcium storage, promoting muscle contraction. Albumin is an important nutrient in the human body and provides the basic material for the anabolism of muscles. The hypersensitive C-reactive protein is an important chronic inflammation marker in vivo, and the IKK/NF-kB/MuRF1 signal channel activation mediated by chronic inflammation reaction can obviously influence the proliferation and differentiation functions of myoblasts and promote the catabolism of contractile proteins.
Furthermore, the dosage of the nutritional supplement is 20-30 g/day.
Compared with the prior art, the nutritional supplement and the application thereof have the following advantages:
(1) the nutritional supplement can obviously improve the walking speed (important evaluation indexes of muscle function attenuation and aging) of the old, effectively increase the 25(OH) D level and the albumin level of serum, reduce the concentration of serum hypersensitive C reactive protein, has ideal effect of improving the muscle attenuation of the old, improves the independent living capacity and the living quality of the old, delays aging and prolongs the health life;
(2) the nutritional supplement is designed aiming at the physiological characteristics and nutritional requirements of the old, is rich in protein components such as easily absorbed amino acids, peptides, high-quality proteins and the like, multiple vitamins and mineral substances, small in toxic and side effects, good in safety, remarkable in effect of improving body functions and cognitive functions, capable of being taken for a long time and good in medicinal prospect.
Drawings
FIG. 1 is an external package used for placebo control, low dose nutritional supplement intervention, and high dose nutritional supplement intervention groups;
figure 2 is a technical roadmap for the intervention study with a double-blind randomized intervention trial.
Detailed Description
Unless defined otherwise, technical terms used in the following examples have the same meanings as commonly understood by one of ordinary skill in the art to which the present invention belongs. The test reagents used in the following examples, unless otherwise specified, were all conventional biochemical reagents; the experimental methods are conventional methods unless otherwise specified.
The present invention will be described in detail below with reference to the following examples and the accompanying drawings.
1. Design of research
Double-blind randomized intervention trials.
2. Selection of study subjects: 132 elderly people with mild cognitive impairment who are 65 years old or older and do not take any nutritional supplement at present are selected as study subjects in the study, and the study subjects are audited by ethical committees and are informed to participate in the study through written consent.
3. The intervention method comprises the following steps: the subjects were randomly divided into 4 groups, blank control group, placebo control group, low dose nutritional supplement intervention group, and high dose nutritional supplement intervention group. Wherein the placebo group adopts soymilk powder placebo without other nutrients; the placebo control group, the low dose nutritional supplement intervention group, and the high dose nutritional supplement intervention group were packaged identically as shown in fig. 1. Wherein, the first and the second end of the pipe are connected with each other,
the dosage of the placebo control group is 13 g/day;
the dosage of the low-dose nutritional supplement intervention group is 13 g/day;
the dosage of the high-dose nutritional supplement intervention group is 26 g/day.
The nutritional supplement and soymilk powder placebo formulations are shown in table 1. The researchers and the study objects do not know group allocation, and the data is decoded after being analyzed. The intervention trial was carried out for 3 months.
TABLE 1 nutritional supplement and soymilk powder placebo formula
Figure BDA0003591857200000141
aRefer to table 2.
TABLE 2 nutrient mix formulation
Figure BDA0003591857200000142
Figure BDA0003591857200000151
4. Evaluation indexes: blood samples are collected before and after intervention, and blood biochemical indexes are measured. Measuring body function indexes such as body composition, grip strength and walking speed. The structured questionnaire was used to assess lifestyle information of the elderly such as cognitive function, dietary nutrient intake, physical activity, smoking, alcohol consumption, etc.
5. Statistical analysis methods and conclusions derived: the impact of "nutritional supplement" intervention on the physical and cognitive function of the elderly was analyzed using one-way anova, logistic regression, etc. methods for comparisons between groups. Based on the above analysis results, the effect of "nutritional supplement" intervention on the improvement of cognitive function, body composition, grip strength, walking speed and blood index of the elderly is clarified.
6. Quality control during interventions
6.1 the powder packages are randomly grouped, and the size, shape, color and smell of the powder packages in each group are the same, so that the influence of factors such as the psychology of a research object and a research executor is avoided.
6.2 telephone follow-up every two weeks, collecting compliance data and monitoring whether adverse reaction and other information exist.
7. Randomized crossover intervention trial technology roadmap
Aiming at the elderly with mild cognitive impairment above 65 years old, a random intervention test is designed, and the improvement effect of physical performance, cognitive function, blood biochemical indexes and the like of the elderly by taking the nutritional supplement is determined. FIG. 2 is a technical route of intervention research.
8. Results of the study
8.1 this study was evaluated by questionnaire and blood sample testing for baseline dietary intake, total energy intake, smoking and drinking habits, physical activity levels, and various blood indicators of the participants, and a comparison of baseline characteristic indicators among the high dose nutritional supplement intervention group, the low dose nutritional supplement intervention group, the placebo-controlled group, and the blank-controlled group is shown in Table 3. Analysis by statistical test showed that all features were not statistically different between the four groups (P >0.05) and baselines were substantially balanced and comparable between groups.
Table 3 random intervention test participants baseline characteristics table (n as 132)
Figure BDA0003591857200000161
Figure BDA0003591857200000171
8.2 before and after 3 months of intervention, the physical ability, cognitive function, serum 25(OH) D, hypersensitive C reactive protein and albumin level of the elderly are evaluated respectively, and the change of each index after the intervention is calculated, which is shown in Table 4. As can be seen from Table 4, after 3 months of intervention, the difference between groups of differences between walking speed before and after (post-intervention-pre-intervention) was statistically significant
(P <0.01), differences between groups of serum albumin pre-and post-differential (post-intervention-pre-intervention) were also statistically significant (P < 0.05). In addition, there were significant differences in changes in serum 25(OH) D
(P < 0.05). Wherein the serum 25(OH) D levels were significantly higher in the high dose nutritional supplement intervention group than in the placebo control group (P <0.01) and the blank control group (P <0.0001) after 3 months of intervention; the low dose nutritional supplement intervention group was significantly higher than the blank control group (P < 0.01).
Table 4 table of changes in physical function, cognitive function and blood index of elderly people of different groups after 3 months intervention (n ═ 132)
Figure BDA0003591857200000172
Figure BDA0003591857200000181
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (10)

1. The nutrient mixture is characterized by comprising the following components in parts by weight: 0.18-0.35 part of vitamin mixture, 0.65-1.15 parts of mineral and 0.03-0.05 part of auxiliary material.
2. The nutrient mix as claimed in claim 1, wherein the vitamin mixture comprises the following components in parts by weight: vitamin A3250.004-0.008 parts, vitamin D1000.006-0.009 parts, vitamin E0.01-0.03 parts, vitamin B10.001-0.003 parts, vitamin B20.01-0.03 parts, vitamin B60.04-0.08 parts, vitamin B120.002-0.004 parts, vitamin C0.1-0.15 parts, nicotinamide 0.008-0.012 parts, folic acid 0.0015-0.003 parts and biotin 0.003-0.005 parts.
3. The nutrient mix as claimed in claim 1, wherein the minerals comprise the following components in parts by weight: 0.06-0.1 part of ferric pyrophosphate, 0.008-0.012 part of zinc oxide, 0.015-0.02 part of sodium selenite and 0.6-1 part of tricalcium phosphate.
4. The nutrient mix as claimed in claim 1, wherein: the auxiliary material is maltodextrin.
5. A nutritional supplement for improving muscle attenuation and delaying aging, which is characterized in that: comprising the nutrient blend of any one of claims 1 to 4, fermented pea protein peptide powder, corn oligopeptide powder, vitamin K2 and soymilk powder composition.
6. The nutritional supplement for improving muscle decline and delaying aging according to claim 5, wherein: the nutrient mixture comprises, by weight, 1-1.5 parts of the nutrient mixture, 0.5-1.5 parts of the fermented pea protein peptide powder, 0.5-1.5 parts of the corn oligopeptide powder, 0.78-0.08 part of vitamin K20.004 and 7.8-11.8 parts of the soybean milk powder composition.
7. The nutritional supplement for improving muscle decline and delaying aging according to claim 6, wherein: the soymilk powder composition comprises 3.5-4.0 parts of instant soybean powder, 3.0-4.0 parts of full cream milk powder, 0.2-0.6 part of dietary fiber, 0.05-0.1 part of konjaku flour, 0.01-0.04 part of momordica grosvenori powder, 0.25-0.75 part of sodium caseinate, 0.05-0.15 part of sodium hexametaphosphate, 0.025-0.075 part of trisodium phosphate, 0.05-0.10 part of tricalcium phosphate, 0.1-0.2 part of thickening agent, 0.025-0.075 part of pH regulator, 0.03-0.1 part of essence and 0.5-1.5 parts of sweetening agent.
8. The nutritional supplement for improving muscle decline and delaying aging according to claim 7, wherein: the dietary fiber is resistant dextrin; the thickening agent is at least one of xanthan gum and carrageenan; the pH regulator is sodium bicarbonate; the essence is at least one of wheat essence and milk essence; the sweetener is at least one of xylitol and stevioside.
9. Use of the nutritional supplement according to claim 5, characterized in that: the nutritional supplement is applied to the preparation of health products for improving the body functions of the elderly, the blood biochemical indexes of the elderly and/or sarcopenia;
preferably, the function of improving the body of the old is to improve the walking speed of the old; the biochemical index for improving the blood of the elderly people is to improve the 25(OH) D level and/or the serum albumin level of the elderly people; the sarcopenia is improved by increasing the concentration of vitamin D and albumin and reducing the concentration of serum hypersensitive C reactive protein.
10. Use of the nutritional supplement according to claim 9, characterized in that: the dosage of the nutritional supplement is 20-30 g/day.
CN202210378872.6A 2022-04-12 2022-04-12 Nutritional supplement for improving muscle attenuation and delaying senescence and application thereof Pending CN114680339A (en)

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