JP2006199641A - Iron-adsorbing polymer substance, iron-containing polymer substance and method for producing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an iron supplement or a substance having an iron-absorption promoting effect and a method for producing the agent, etc. <P>SOLUTION: A substance having iron-adsorbing property and an iron-containing polymer substance can be produced from a fermentation decomposition product produced from soybean as a raw material and using a microorganism such as Aspergillus oryzae or an enzyme. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an iron absorption promoter and an iron reinforcing agent that promote iron absorption and improve iron deficiency.

Iron is one of the essential micronutrients essential for maintaining life, and is a major component of hemoglobin in red blood cells that carry oxygen, as well as myoglobin in muscles and enzymes involved in redox in the body It is important as a component of blood and is an indispensable factor for blood-increasing action in vivo.
According to a recent National Nutrition Survey, even though the average intake of iron as a national standard is almost met on the average for men and women, half of the menstrual women are said to be iron deficient. In addition, it is pointed out that growing children have a tendency to become iron deficient, and it is necessary to prevent and improve various symptoms such as anemia caused by iron deficiency. In addition, serum iron and hemoglobin content decrease after blood donation, surgery, and postpartum, but it takes a long time to return to the original normal value, and it is desirable to shorten this recovery period as much as possible. Yes.

It is thought that women who need to have nearly twice as much iron as adult men need, but the amount of iron intake is almost proportional to the amount of calorie intake. Is considered to be below the required amount. Another problem is that the intake of meat and liver containing heme iron, which has a good absorption rate, is less than men's preference and diet-oriented.
Iron deficiency is caused by bleeding, intraurethral bleeding, pregnancy, intake of an iron deficient diet, abnormal absorption of iron from the intestine, etc., and if this persists, it leads to iron deficiency anemia. Conventionally, in the case of iron deficiency, ingestion of non-heme iron such as iron citrate, iron lactate, ferric chloride and iron sulfate and heme iron contained in meat, liver, etc., and absorption of iron such as vitamin C and cysteine It is recommended to eat foods with a lot of ingredients that promote the absorption of food, and it is desirable to avoid ingestion of foods rich in phytic acid, phosphoric acid, tannic acid, etc. that reduce iron absorption.

  So far, those having iron absorption promoting activity include vinegar (see, for example, Patent Document 1), triterpene glycoside (see, for example, Patent Document 2), carnosine, anserine, valenin, and π-methylhistidine. One or more imidazole compounds selected from (for example, see Patent Document 3), guar gum enzyme degradation products (for example, see Patent Document 4), peptides obtained from fish proteolytic enzyme solution (for example, see Patent Document 5) However, there are still problems that are insufficient in action and effect and that it is difficult to stably blend into the preparation while maintaining the activity.

Looking further at the world, iron deficiency anemia is one of the most delayed health problems, especially in developing countries. Economic and effective iron addition by international organizations such as WHO and UNICEF. A program has been implemented (see, for example, Non-Patent Document 1). Foods to which iron is added need to be taken on a daily basis, and grains, such as flour and rice, and seasonings such as salt, sugar, and soy sauce have been added with iron. In Asian regions, particularly in Vietnam and China, iron-enriched soy sauce is selected as a food with higher iron absorption efficiency than cereals, and an increase in hemoglobin levels has been confirmed by human intervention tests (see Non-Patent Document 2, for example). Therefore, so far, it has been clarified that soy sauce is effective as a medium for adding iron, but the soy sauce component involved in promoting iron absorption has not been elucidated at all.
JP 2003-146873 A JP 2000-109498 JP 07-097323 A Japanese Patent Laid-Open No. 06-247860 Japanese Patent Laid-Open No. 05-229959 International Cooperation Research, 19 (1), 39-48, 2003 Eur. J. Clin. Nutr., 44, 419-424, 1990

It is known that iron is a trace element that is difficult to be absorbed into the blood, and about 10% of iron is absorbed from the intestinal tract. Therefore, even if a large amount of iron is orally ingested, most of the ingested iron is discharged out of the body as it is, and therefore, a material that promotes the absorption of iron from the intestinal tract is desired.
This invention is made | formed in view of the said situation, Comprising: It aims at providing the substance which has the iron reinforcement agent excellent in economical and safety | security, or an iron absorption promotion effect, and its manufacturing method.
Furthermore, an object of the present invention is to provide foods, beverages, pharmaceuticals and feeds having physiological activity of promoting iron absorption to which such substances are added.

As a result of studying a substance having an iron reinforcing effect and an absorption promoting effect, the present inventors have found that the polymer substance contained in soy sauce contains iron in a high concentration, and this substance further adsorbs iron ions. It has been discovered that it is possible and effective as an iron reinforcing agent, and the present invention has been made. Furthermore, it discovered that the fermented soybean of the main raw material of soy sauce had the same effect, and came to make this invention.
The iron-adsorbing substance and the iron-containing polymer substance of the present invention can be obtained from fermented decomposition products using soybeans as raw materials and microorganisms such as koji molds or enzymes. These polymer substances are expressed in the fermentation decomposition product, and are obtained as an iron-adsorbing polymer substance and / or an iron-containing polymer substance depending on the amount of iron ions in the fermentation decomposition product. Typical examples of the fermentation decomposition product include soy sauce and soy sauce cake. The substance of the present invention is dilute alcohol-soluble, concentrated alcohol-insoluble and water-soluble, the iron-adsorbing polymer substance has a molecular weight of 6,000 or more, and the iron-containing polymer substance contains about 200 ppm or more of iron.

That is, this invention relates to the iron reinforcing agent and iron absorption promoter of following (1)-(12).
1. An iron-adsorbing polymer material obtained from fermentative decomposition products of raw materials containing soybeans and having the following properties.
(1) When dialyzed with a dialysis membrane having a molecular weight cut off of 6,000, it remains in the dialyzed solution.
(2) Soluble in water and insoluble in organic solvents such as alcohol.
(3) Ability to chelate iron.
2. An iron-containing polymer substance having the following properties obtained from a fermentative decomposition product of raw materials containing soybeans.
(1) When dialyzed with a dialysis membrane having a molecular weight cut off of 6,000, it remains in the dialyzed solution.
(2) Soluble in water and insoluble in organic solvents such as alcohol.
(3) Contains 200 ppm or more of iron.
3. The fermentative decomposition product of the raw material containing soybean, or its water extract, saline extract or dilute alcohol extract is obtained by dialysis, ultrafiltration and / or alcohol precipitation. Iron-adsorbing polymer material or iron-containing polymer material.
4. An iron-containing polymer material obtained by adding iron ions to a solution of the iron-adsorbing polymer material according to claim 1 or 3.
5. The fermentative decomposition product containing soybean is rice bran using a raw material containing soy sauce or soybean, Iron-adsorbing polymer material or iron-containing polymer material according to any one of claims 1 to 3 .
6. Iron characterized by collecting high-molecular substances by dialysis, ultrafiltration and / or alcohol precipitation of fermented decomposition products of raw materials containing soybeans, or water extracts, salt extracts or dilute alcohol extracts thereof. Method for producing adsorptive polymer substance or iron-containing polymer substance.
7. When obtaining fermented decomposition products of raw materials containing soybeans, or water, salt solution or dilute alcohol extracts thereof, iron ions are added in advance, or iron is added to the obtained fermentation decomposition products or extracts thereof. A method for producing an iron-containing polymer material, comprising adding ions and then collecting the polymer material by dialysis, ultrafiltration and / or alcohol precipitation.
8. An iron reinforcing agent comprising the iron-containing polymer substance according to any one of claims 2 to 5 as an active ingredient and containing or not containing other iron compounds.
9. An iron absorption promoter comprising as an active ingredient the iron-adsorptive polymer material according to any one of claims 1, 3 and 5.
10. A food comprising the iron-adsorbing polymer substance and / or the iron-containing polymer substance according to any one of claims 1 to 5.
11. A feed comprising the iron-absorbing polymer material and / or iron-containing polymer material according to any one of claims 1 to 5.
12. A pharmaceutical product comprising the iron-absorbing polymer substance and / or the iron-containing polymer substance according to any one of claims 1 to 5.
The medicament of the present invention includes quasi drugs.

The polymer substance obtained from the fermented decomposition product of soybean of the present invention has an iron adsorptive action and / or an iron absorption promoting action containing about 200 ppm or more of iron. It can be used as food or drink or medicine. And it is highly safe, can be ingested continuously, can be supplied in large quantities, can be easily added to foods, etc., and contributes to health promotion of humans and the like. Furthermore, the iron-adsorptive polymer substance and iron-containing polymer substance of the present invention have symptoms caused by insufficient use of iron, such as anemia, headache, tinnitus, shortness of breath, dizziness, movement disorder, malaise, etc. Application to iron deficiency after blood donation, surgery, and postpartum is expected.
Further, according to the method of the present invention, a polymer substance having such an effect can be easily produced in large quantities.

  A heat treatment such as steaming or roasting soybean is performed, and an active ingredient according to the present invention is generated by growing filamentous fungi such as koji molds. In order to promote the growth of filamentous fungi, various nutrient sources can also be supplemented. The iron-adsorptive polymer substance according to the present invention thus produced remains even if it is fermented for a long time in water, saline or dilute ethanol of less than about 30% (v / v). Examples of these are soy sauce cake or soy sauce.

The iron-adsorbing polymer substance or iron-containing polymer substance in the present invention is expressed in a fermentation decomposition product and can be used as it is. In order to make it easier to use, it can be extracted or the polymer fraction can be concentrated by the following means.
When the fermented decomposition product is solid, in order to collect the polymer substance of the present invention, it is necessary to use about 1 to 10 parts by weight of water, saline, or diluted ethanol less than about 30% (v / v). Extraction is performed for 1 hour to several days under the condition that the physiologically active ingredient of the invention can be dissolved, and the filtrate is used.
Concentrating the dialyzed filtrate of the above decomposition product and concentrating the dialyzed solution, adding concentrated ethanol to collect the insoluble material produced by filtration or centrifugation, or passing these liquids through an ultrafiltration membrane A method of collecting a non-permeate that is a fraction containing a polymer substance by the above, or a method of adding concentrated ethanol to this non-permeate to produce an insoluble material and recovering it can be used.

  The amount of ethanol added to collect the polymer substance according to the present invention may be a concentration at which the polymer substance becomes insoluble, and the final ethanol concentration is 30% (v / v) or more, preferably 50% (v / v) or more. Although the polymer substance of the present invention can be recovered by using alcohol such as methanol or 2-propanol instead of ethanol, ethanol is preferred from the viewpoint of safety. The remaining liquid obtained by collecting the polymer fraction of the present invention can be used for recovering the polymer material from a new raw material. This solution contains amino acids and low molecular weight carbohydrates together with added ethanol or other alcohols, and is separated from ethanol by an operation such as distillation. Alcohols such as ethanol can be reused in the present invention, and non-volatile components can be used as seasonings and foods.

In addition, when the polymer material of the present invention is produced using soy sauce as a raw material, the polymer material is an iron-containing polymer material containing about 0.1% iron, and can be used as an iron reinforcing agent. . Further, the iron content in the polymer material obtained from the water extract of persimmon is lower than that obtained from soy sauce, but the iron-containing polymer material containing about 200 ppm or more of iron does not need to be added with iron. It can be used as an iron reinforcing agent.
Furthermore, the iron-containing polymer substance according to the present invention can be produced by adding and dissolving the iron-adsorptive polymer substance in a solution containing iron ions such as ferrous sulfate. Moreover, it can also manufacture by adding iron ions, such as ferrous sulfate, to the extract which extracted soy sauce or rice cake with water, salt solution, and diluted ethanol. The iron content is enhanced by methods such as dialysis of these solutions to collect dialysis internal fluid, collection of non-permeate by ultrafiltration, precipitation by adding ethanol, or a combination thereof. A polymer substance related to the invention is obtained.
The obtained high molecular weight substance can be used in the form dissolved in water, powdered form, or as it is, and may be used as a preparation, and it may be a food, drink, feed, pharmaceutical (including quasi drugs). It can mix | blend suitably.

For the iron-adsorbing polymer substance and iron-containing polymer substance of the present invention, the extract obtained by the above method may be used directly as it is, or it may be used after being dried by a conventional method such as spray drying or freeze drying. You can also.
It is generally dissolved or dispersed in a suitable liquid carrier, or mixed with or adsorbed to a suitable powder carrier, and in some cases, further emulsifier, dispersant, suspending agent, spreading Additives, penetrants, wetting agents, stabilizers, etc. are added and used as preparations such as emulsions, oils, wettable powders, powders, tablets, capsules, and liquids. When used as an iron reinforcing agent, the amount used is preferably about 5 to 10 mg per day for foods and about 10 to 100 mg for pharmaceuticals.

In obtaining an iron-reinforced food or drink, the method of adding the polymer substance of the present invention to the food or drink may be a generally performed method.
Examples of these foods and beverages include chewing gum, candy, tablet confectionery, gummi, jelly, chocolate, biscuits or snacks and other confectionery, ice cream, sorbet or ice confectionary frozen confectionery, beverages, pudding, jam, dairy products, etc. It is possible to enhance iron absorption by daily intake of these foods and drinks.

  The polymer substance of the present invention can also be used to increase iron content in women and infants who need iron supplementation as pharmaceuticals. The dosage form is not particularly limited, and can be used in combination with a pharmaceutically acceptable carrier. The dosage form is not particularly limited, and examples thereof include oral preparations such as powders, fine granules, granules, tablets, capsules, suspensions, emulsions, syrups, extracts, or pills. it can. Oral agents are excipients, binders, disintegrants, surfactants, lubricants, fluidity promoters, diluents, preservatives, colorants, fragrances, stabilizers, humectants, preservatives, or antioxidants It can manufacture according to a conventional method using an agent.

  Furthermore, when the polymer substance of the present invention is used for the purpose of enhancing iron absorption, it is effective to appropriately mix vitamin C and other iron absorption metabolism promoters, iron compounds and the like. Moreover, various substances, such as a nutrient and a trace element, can also be mixed in the range which does not prevent the effect of this invention. Examples of the iron compound include, but are not limited to, iron chloride, ferrous sulfate, ferrous citrate, ammonium iron citrate, sodium iron citrate, iron lactate, iron pyrophosphate, and other inorganic or organic iron compounds. It can be used appropriately, and the blending amount may be the same as that of the commercially available iron agent. In the present invention, since a high iron absorption effect can be expected, even if a small amount of iron is blended, it can be used effectively.

  An example of means for obtaining the polymer substance of the present invention is shown below. However, the present invention is not particularly limited to such a method.

Iron reinforcement and absorption promotion action of polymer material obtained from soy sauce (polymer material obtained from soy sauce)
10 L of soy sauce made mainly from defatted soybeans, whole soybeans and wheat is desalted to a salt concentration of about 3%, mixed with 20 L of ethanol, and the precipitate is collected by centrifugation and freeze-dried. About 100 g of a dried product was obtained and pulverized to obtain a polymer material. This dry polymer material contained 1000 ppm of iron and had iron chelating ability. This iron content suggests that most of the iron contained in the soy sauce used as a raw material is adsorbed by the polymer component.
This high molecular weight substance remains in the dialysis internal solution when dialyzed with a dialysis membrane having a molecular weight cut off of 6,000, is soluble in water, saline and dilute alcohol, and is insoluble in organic solvents such as concentrated alcohol and ethyl ether.
A human intake evaluation test was conducted using this polymer substance. That is, the test food is one in which capsules are filled with a powder containing 150 mg of a high-molecular substance (0.15 mg as iron) per capsule, crystalline cellulose, a small amount of sucrose fatty acid ester and silicon dioxide. In addition, the control food is a capsule filled with a powder prepared with the same composition as above without adding a polymer substance.
(subject)
The subjects were 45 meridian women, who fully explained the purpose and method of this study, and conducted an evaluation study with their written consent in accordance with the purpose of the Declaration of Helsinki.

(Human intake evaluation test)
As shown in Table 1, subjects were assigned to two groups: a polymer substance intake group (test food, iron content 0.15 mg / 1 capsule) and a placebo intake group (control food, iron content 0.0 mg / 1 capsule). A double-blind comparative study was conducted to examine the effect of the test subject in a state where no one knew the group to which the subject belonged. The test food group (22 persons) was instructed to take the test food containing the polymer substance twice a day in the morning and evening to take 2 capsules a total of 4 capsules per day (0.6 mg of iron). On the other hand, the control food group (23 persons) was instructed to take a total of 4 capsules per day, divided into 2 mornings and evenings for the control foods that do not contain a polymer substance. In addition, there are no restrictions on daily eating habits and activities. Blood samples were collected before ingestion and 4 weeks after ingestion, and the red blood cell count, serum iron, hematocrit, and hemoglobin content were examined. The blood test results are shown in Table 2. For comparison between the two groups, a student-t test was performed, and a risk rate of less than 5% was determined to be significant, * in the table was less than 5% risk rate, ** was less than 1% risk rate, and NS indicates no significant difference. As can be seen from the table, serum iron, hematocrit, and hemoglobin content are statistically significantly improved compared to the control group, and the red blood cell count is less than 10%, which is clearly improving.
According to the Ministry of Health, Labor and Welfare's “National Nutrition Status” 2002 edition, the average daily iron intake for general adults is approximately 11 mg. It is stipulated to be food. The intake from the test food in this study is only 0.6 mg, but it is clearly shown that the test food is more efficiently absorbing iron than the control food, as shown in Table 2. ing. This result suggests that the iron-containing polymer according to the present invention is useful as an iron reinforcing agent and promotes absorption of iron present in normal foods other than iron supplied from test foods. It was.

  Dissolve 1 g of the polymer substance powder obtained from the soy sauce of Example 1 in 100 ml of water, add 20 mg of ferrous sulfate dissolved in a small amount of water, and after stirring, add it to a dialysis tube with a molecular weight cut off of 6,000. Packed and dialyzed overnight in running water to remove unadsorbed ferrous sulfate. Thereafter, the powder obtained by freeze-drying the dialysis internal solution contained 1300 ppm of iron, and it was clear that the iron-containing polymer substance obtained from soy sauce further had iron adsorption properties.

Manufacturing method from straw (Manufacturing polymer material)
100 g of soybeans was placed in a 3 L Erlenmeyer flask, 120 ml of hot water was added, and the mixture was left for 30 minutes. Subsequently, 90 g of roasted cracked wheat was added and stirred well, followed by autoclaving at 121 ° C. for 45 minutes. After standing to cool, 1 g of Aspergillus oryzae spores were inoculated and stirred well. Thereafter, static culture was performed in a water bath maintained at 30 ° C. for 48 hours. In the meantime, maintenance was carried out twice for stirring (after 20 hours and after 30 hours).
150 ml of pure water was added to a part (90 g) of the cultured koji and homogenized at 10,000 rpm for 15 minutes. The homogenate solution was centrifuged at 7,000 rpm for 30 minutes, and the supernatant was collected to obtain a water extract of each bottle.
The water extract was packed in a dialysis tube having a molecular weight cut off of 6,000, dialyzed overnight in running water, and the precipitate obtained by adding ethanol to the dialyzed solution to 60% was collected by centrifugation. This precipitate was dried under reduced pressure at 50 ° C. to obtain an iron-containing polymer substance having iron adsorptivity according to the present invention. This dried product had an iron chelating power and contained 500 ppm of iron.
Furthermore, after adding 0.1 g of the above-mentioned polymer substance to 20 ml of water in which 2 mg of ferrous sulfate is dissolved, stirring and dissolving, the mixture is packed in a dialysis tube with a molecular weight cut off of 6,000 and dialyzed in running water overnight. After removing iron, the dialyzed solution was lyophilized. This dried product contained 1500 ppm of iron.
The two dried products were soluble in water, saline and dilute alcohol, and insoluble in organic solvents such as concentrated alcohol and ethyl ether.

(Production method using enzymes)
50 g of bran was placed in a 3 L Erlenmeyer flask, 120 ml of water was added, and the mixture was well stirred and mixed, and then sterilized at 121 ° C. for 30 minutes in an autoclave. After cooling, 0.05 g of Asp. Orizae spores were added and stirred well, followed by culturing in a 30 ° C. water bath for 96 hours. During the cultivation, the mixture was stirred after 20 hours and 40 hours. The culture was homogenized with 300 ml of water, and then centrifuged to obtain 200 ml of extract. This extract was filtered through a 0.45 μm filter to obtain a sterile enzyme solution.
On the other hand, 20 g of soybeans was put into a 200 ml Erlenmeyer flask, 30 ml of hot water was added, and the mixture was stirred and allowed to stand for 30 minutes. To this, 100 ml of an aseptic enzyme solution obtained from the above bran koji was aseptically added, shaken in a 30 ° C. water bath for 96 hours, and then centrifuged to obtain 80 ml of a fermentation decomposition solution. 30 ml of this fermentation decomposition solution was packed in a dialysis tube having a molecular weight cut off of 6,000, dialyzed in running water overnight, and the dialysis internal solution was lyophilized to obtain a dried product. This dried product exhibited iron chelating power and contained 200 ppm of iron. The two dried products were soluble in water and insoluble in organic solvents such as concentrated alcohol and ethyl ether.
In addition, 5 mg of ferrous sulfate dissolved in a small amount of water was added to 50 ml of the remaining fermentation decomposition solution, stirred, dialyzed overnight in running water, and the dialysis internal solution was freeze-dried. It contained 1200 ppm of iron. A polymer powder was obtained.

  30 L of 15% ethanol containing 10 mg / L ferrous sulfate as iron ions was added to 10 kg of soybean meal and refrigerated for 1 week, followed by filtration to obtain 20 L of extract. This was applied to an ultrafilter equipped with an ultrafiltration membrane having a molecular weight cut off of 6,000 to obtain 2 L of a non-permeate. 4 L of ethanol was added thereto, and the mixture was stirred and allowed to stand for 1 day. The produced precipitate was collected by decantation, and this was decompressed at 50 ° C. to obtain 300 g of a dry powder. This powder contained 1100 ppm of iron and did not decrease even when dissolved in water and dialyzed, and it was assumed that iron was taken up by the polymer substance. This powder was soluble in water, saline, dilute alcohol, and insoluble in organic solvents such as concentrated alcohol and ethyl ether.

(Iron-enriched soy sauce)
50 g of the iron-adsorbing polymer material obtained in the same manner as in Example 1 and 2.4 g of iron citrate were added to 1,000 ml of commercially available soy sauce, mixed and dissolved to prepare iron-reinforced soy sauce. This soy sauce contains about 5 mg of iron in 10 ml.
In addition, when ferrous citrate is added to normal soy sauce and stored, the browning rate becomes very large and storage stability is poor, but the browning rate of soy sauce to which the iron-adsorbing polymer material of the present invention is added is only ferrous citrate. This was clearly smaller than the soy sauce added with sucrose, suggesting an effect of inhibiting browning.

(Prescription of powdered food)
A powdered food was obtained by mixing 10% of freeze-dried powder, 20% of potato starch and 70% of lactose obtained in the same manner as in Example 2.
10 g of this powder contains about 1 mg of iron.

(Beverage prescription)
An orange juice drink was obtained by mixing 2.5% of the freeze-dried powder obtained in the same manner as in Example 2, 5% orange juice, 15% isomerized sugar, 0.1% ascorbic acid, 0.1% fragrance and 74.8% water. 200ml of this beverage contains about 5mg of iron.

(Medicine)
50% of the dry powder obtained in the same manner as in Example 2, 35% dextrin and 15% iron fumarate are mixed, and 0.2 g is filled into a gelatin capsule. Each capsule contains about 10 mg of iron.

  The polymer substance obtained by the present invention has an iron absorption promoting action, and can be used as an iron absorption promoter, iron absorption promoting food and drink, feed, etc., symptoms caused by insufficient use of iron, For example, it is expected to be applied to iron deficiency after anemia, headache, tinnitus, shortness of breath, dizziness, movement disorder, malaise, blood donation, surgery, and postpartum.

Claims (12)

An iron-adsorbing polymer material obtained from a fermentative decomposition product of raw materials containing soybeans and having the following properties.
(1) When dialyzed with a dialysis membrane having a molecular weight cut off of 6,000, it remains in the dialyzed solution.
(2) Soluble in water and insoluble in organic solvents such as alcohol.
(3) It has the ability to chelate iron. An iron-containing polymer substance having the following properties obtained from a fermentative decomposition product of raw materials containing soybeans.
(1) When dialyzed with a dialysis membrane having a molecular weight cut off of 6,000, it remains in the dialyzed solution.
(2) Soluble in water and insoluble in organic solvents such as alcohol.
(3) Containing 200 ppm or more of iron. The iron adsorption according to claim 1 or 2, which is obtained by dialysis, ultrafiltration and / or alcohol precipitation of a fermentative decomposition product of a raw material containing soybean, or a water extract, a saline extract or a dilute alcohol extract thereof. Polymer material or iron-containing polymer material. An iron-containing polymer substance obtained by adding iron ions to a solution of the iron-adsorbing polymer substance according to claim 1 or 3. The iron-adsorbing polymer material or the iron-containing polymer material according to any one of claims 1 to 3, wherein the fermentative decomposition product of the raw material containing soybeans is rice cake using soy sauce or a raw material containing soybeans. . Fermentation degradation product of raw material containing soybean, or its water extract, salt extract or dilute alcohol extract is dialyzed, ultrafiltered and / or precipitated with alcohol to collect a high molecular weight substance. A method for producing a polymer substance or an iron-containing polymer substance. When obtaining fermented decomposition products of raw materials containing soybeans, or water, saline or dilute alcohol extracts thereof, iron ions are added in advance, or iron ions are added to the obtained fermentation decomposition products or extracts thereof. A method for producing an iron-containing polymer material comprising adding the polymer material and then collecting the polymer material by dialysis, ultrafiltration and / or alcohol precipitation. An iron reinforcing agent comprising the iron-containing polymer substance according to any one of claims 2 to 5 as an active ingredient and containing or not containing other iron compounds. The iron absorption promoter which uses the iron adsorptive polymer substance in any one of Claims 1, 3, and 5 as an active ingredient. A food characterized by adding the iron-absorbing polymer substance and / or the iron-containing polymer substance according to any one of claims 1 to 5. A feed comprising the iron-absorbing polymer substance and / or the iron-containing polymer substance according to any one of claims 1 to 5. A pharmaceutical product comprising the iron-absorbing polymer substance and / or the iron-containing polymer substance according to any one of claims 1 to 5.