CN109077302A - A kind of medical food and preparation method thereof treating and preventing old aged muscle decaying syndrome - Google Patents

A kind of medical food and preparation method thereof treating and preventing old aged muscle decaying syndrome Download PDF

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Publication number
CN109077302A
CN109077302A CN201810791304.2A CN201810791304A CN109077302A CN 109077302 A CN109077302 A CN 109077302A CN 201810791304 A CN201810791304 A CN 201810791304A CN 109077302 A CN109077302 A CN 109077302A
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vitamin
syndrome
treating
medical food
old aged
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卢秀莲
杨艳芳
刘慧丽
闫猛
张辰辰
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CISEN PHARMACEUTICAL Co Ltd
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CISEN PHARMACEUTICAL Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The present invention provides a kind of medical food and preparation method thereof for the treatment of and prevention old aged muscle decaying syndrome.Based on the special medicine purposes formula food 1000ml, the nutrient includes: protein 56-82g, fat 20-31g, carbohydrate 110-160g, vitamin 1.5-2.6g, minerals 20-30g, water 690-800g；The present invention provides a kind of specific full nutrition special medicine purposes formula food for sarcopenia patient containing beta-hydroxy-methylbutanoic acid calcium and creatine rich in small peptide class high-quality protein, optimization Fatty acids composition by reasonable raw material proportioning and use.The present invention has good preventive and therapeutic action to the elderly's sarcopenia, can delay the occurrence and development of sarcopenia.

Description

It is a kind of treat and prevent old aged muscle decaying syndrome medical food and its preparation Method
Technical field
The invention belongs to medical screen technical field, in particular to a kind for the treatment of and prevention old aged muscle decaying syndrome Medical food and preparation method thereof is suitable for the elderly and muscle depletion syndrome patients, by tube feed or takes orally, as single Source of nutrition provides nutritional support for patient.
Technical background
On May 1st, 2011, China National Bureau of Statistics of China disclose sixth national census as a result, announcing that China is comprehensive Into ageing stage.Related newest result of study shows, it is contemplated that the population to the year two thousand fifty whole world 60 years old or more will be more than 20 Hundred million, and wherein 500,000,000 populations are in China.With age, the great change that body occurs is exactly the skeletal muscle of duration The decline of Mass lost and muscular strength and body function.It began to suffer from muscle decaying at 50 years old researches show that there are about the people of 1%-2% Disease, the people of 5%-13% suffered from muscle decaying disease at 60-70 years old；And suffer within 80 years old or more muscle decaying disease crowd then more than 50%.
Sarcopenia (Sarcopenia) is that progressive skeletal muscle amount relevant to age is increased is reduced, with muscular force Amount and (or) the syndrome of muscle function decline.A large amount of studies have shown that muscle decaying will lead to muscle strength decrease, activity subtracts Less, the problems such as being easy tumble, quality of life decline, additionally increases having diabetes, heart and brain blood systemic disease, osteoporosis etc. The danger of disease brings heavy financial burden to health delivery system and society.
As China enters the aging of population stage, people are fully recognized that the harm of sarcopenia and carry out product Pole prevention and treatment is of great significance to improving life of elderly person quality, reducing complication.
The reason of causing muscle to be decayed, has very much, wherein mainly due to energy or protein insufficiency of intake, gastrointestinal tract function Can disorder, caused by Disorder of Digestion and A orption.Wherein protein malnutrition is one of its main risk factor.With the age Increase, the ability of body itself synthetic proteins matter reduces, and catabolism activity enhancing, digestive function decline etc. leads to the elderly's egg The uptake and utilization rate of white matter decline.
Nutritional supplementation is to improve one of old aged muscle decaying major way.Studies have shown that carrying out science equilibrium to patient Nutritional intervention effectively can prevent and delay muscle attenuation process.
Special medicine purposes formula food (Foods for Special Medical Purpose, FSMP), referred to as special doctor Food is to meet limited feed, Disorder of Digestion and A orption, metabolic disorder or particular disease states crowd to nutrient or diet Special requirement, specially process the formula food being formulated.
It is used for the enteral nutrition food squeeze of " sarcopenia " patient, existing a few money products currently on the market It is not designed directed entirely to physiology, nutritional character and the demand of muscle decaying disease patient, cannot effectively improve patient battalion Defective mode is supported, to inhibit and reverse the generation of the various complication as caused by protein malnutrition.Meanwhile materials are not Meet " special medicine purposes formula food " (GB29922) related request.
Summary of the invention
In view of the above-mentioned problems, requirement of the present invention according to GB29922, in conjunction with the physilogical characteristics of muscle depletion syndrome patients And nutritional need, the research achievements such as comprehensive newest nutrition, clinical medicine and fundamental biological knowledge, using hydrolyzing lactoalbumin, pea Legumin peptide, wheat oligopeptide, ocean fish oligopeptide powder and leucine provide nitrogen source, other is cooperated to provide carbohydrate and rouge Raw material and dietary fiber, the multivitamin and minerals of fat, not only serving as single nutrient source is sarcopenia Patient provides comprehensively and balanced nutrition, additionally it is possible to promote the increase of body musculature and the enhancing of muscle strength, Neng Gouyou The improvement of effect and the muscle decay for inhibiting sarcopenia patient.
Above-mentioned purpose of the invention is achieved through the following technical solutions:
The present invention provides a kind of medical food for the treatment of and prevention old aged muscle decaying syndrome, by the medical food 1000ml meter, include: protein 56-82g, fat 20-31g, carbohydrate 110-160g, dietary fiber 10.5-16.2g, Beta-hydroxy-methylbutanoic acid calcium 0.9-1.6g, creatine 2.2-3.2g, vitamin 1.5-2.6g, minerals 20-30g and water 690- 800g；
Wherein, the protein includes hydrolyzing lactoalbumin 22-36g, pea protein peptide 13-20g, wheat oligopeptide 13- 20g, ocean fish oligopeptide powder 4.2-6.5g, leucine 1.6-2.5g；
The fat includes medium chain triglyceride 7.2-11.5g, tea seed oil 5.5-8.5g, rapeseed oil 4.5-7.0g, is total to Conjugated linoleic acid 1.5-2.5g, fish oil 2.0-3.5g；
The carbohydrate includes maltodextrin 70-105g, fructose 22-35g, resistant starch 13-20g；
The vitamin includes vitamin A 3.1-4.5mg, vitamin C 1.1-1.58g, vitamin D3 16.5-24μg、 Vitamin E 55-82mg, vitamin K11142-205 μ g, vitamin B14.2-6.5mg, vitamin B25.6-8.2mg, dimension life Plain B65.6-8.2mg, pantothenic acid 13.9-21.2mg, biotin 8.5-12.5mg, folic acid 7.5-10.5mg, niacinamide 19.5- 28.2mg, vitamin B126.2-8.9ug, choline 330-479mg；
The minerals include calcium chloride 2.4-3.6g, potassium hydroxide 0.3-0.49g, potassium citrate 0.96-1.55g, phosphorus Sour hydrogen dipotassium 3.3-5.2g, sodium citrate 4.0-6.5g, magnesium chloride 2.1-3.2g, six hydrated chromium trichloride 13.5-18.6mg, Portugal Grape saccharic acid copper 18.2-28.5mg, three hydration ferrous lactate 80.5-118.2mg, Manganous sulfate monohydrate 11.2-17.9mg, two hydrations Sodium molybdate 7.5-11.6mg, sodium selenite 26.6-40.2mg, Zinc sulfate monohydrate 40.9-60.5mg, 10% potassium iodide 2.8- 4.2g。
Preferably, the medical food for treating and preventing old aged muscle decaying syndrome includes protein 65g, fat 34.5g, carbohydrate 126g, dietary fiber 12.4g, vitamin 2.0g, minerals 24g, water 770g.
Preferably, the protein include hydrolyzing lactoalbumin 28g, pea protein peptide 15.2g, wheat oligopeptide 15.2g, Leucine 2.0g.
Preferably, the fat includes medium chain triglyceride 8.5g, tea seed oil 6.5g, rapeseed oil 5.3g, the sub- oil of conjugation Sour 1.9g, fish oil 2.5g.
Preferably, the carbohydrate includes maltodextrin 85g, fructose 26g, resistant starch 15g；It also include oligomeric fruit Sugared 3.6g, xylo-oligosaccharide 3.6g, isomaltose 12.4g.
Preferably, the vitamin includes vitamin A 3.62mg, vitamin C 1.26g, vitamin D319.2 μ g, dimension Raw element E 64mg, vitamin K1160 μ g, vitamin B14.8mg, vitamin B26.4mg, vitamin B66.4mg, pantothenic acid 16.64mg, biotin 9.6mg, folic acid 8.0ug, niacinamide 22.4mg, vitamin B127.04 μ g, choline 380mg.
Preferably, the minerals include calcium chloride 2.8g, potassium hydroxide 0.4g, potassium citrate 1.2g, dipotassium hydrogen phosphate 4.0g, sodium citrate 5.0g, magnesium chloride 2.5g, six hydrated chromium trichloride 14.35mg, copper gluconate 21.25mg, three hydration creams Sour ferrous iron 93.85mg, Manganous sulfate monohydrate 14.0mg, two molybdic acid hydrate sodium 8.83mg, sodium selenite 32.2mg, sulfuric acid monohydrate Zinc 48.03mg, 10% potassium iodide 3.3g.
Preferably, the medical food for treating and preventing old aged muscle decaying syndrome includes beta-hydroxy-methylbutanoic acid Calcium 1.2g and creatine 2.5g.
Preferably, nutritional agents described in the medical food for treating and preventing old aged muscle decaying syndrome includes emulsifier Soybean lecithin 1.1-1.8g, acidity regulator citric acid 1.7-2.6g, colorant natural Beta-carotene 0.7-1.2g.
The energy supply ratio of special medicine purposes formula food protein of the present invention, fat and carbohydrate is 25:25: 50。
The present invention also provides the preparation methods of the special medicine purposes food described in one kind, comprising the following steps:
(1) aniseed dissolves: the pure water of total amount 65%-75% being added in dissolving tank, will consolidate under strong Vibratory Mixing Body raw material is sequentially added into dissolving tank, so that feed liquid is flowed back uniformly by carrying out under liquid level, is uniformly dispersed in pure water, together When avoid generating excessive bubble and feed liquid layering.Nitrogen is constantly passed through into lotion in entire process for preparation；
(2) oil is mutually prepared: oils raw material and liposoluble vitamin being mixed well dissolution in order, are heated to 40-60 DEG C；
(3) 60 DEG C or so progress homogeneous homogeneous: are cooled to after water phase is mutually mixed well with oil；
It (4) will be filling after the feed liquid cooling after homogeneous；
(5) terminal sterilization: being placed in rotation for product, sterilize in fountain sterilizing cabinet, and 121 DEG C of sterilising temp, F0 value 8-12, Obtain finished product.
Special medicine purposes formula food of the present invention increases and muscle decaying caused by malnutrition for the age Syndrome patients.Special medicine purposes formula food of the present invention includes the nutrient that human body needs, i.e. carbohydrate, rouge Fat, proteins,vitamins,minerals, water meet " Dietary Reference Intakes of Chinese Residents ", and nutrition is comprehensive, proportion is equal Weighing apparatus.Small peptide that is high-quality and being not required to digest and can directly be absorbed by organisms all is selected to provide nitrogen source in the present invention.These small peptides The nitrogen source bioavailability of class is far superior to whole albumen.Therefore, can be low for digestive function, the muscle decaying that protein lacks Syndrome patients provide optimal nitrogen source.Fatty acid composition is optimized simultaneously, provides a variety of fatty acid of proportion science for body.
The special medicine purposes formula food of the present invention has been especially added with creatine and beta-hydroxy-Beta-methyl fourth Sour calcium can promote the synthesis of muscle and the raising of muscle strength.The special medicine purposes formula food of the present invention Carbohydrate source in maltodextrin, fructose and resistant starch.On USA Magazine " Clinical Endocrinology and metabology " An investigation point out that the intake of excessive fructose may cause hepatic injury, aggravate burden of liver, and be converted into fatty liver, in turn Cause hyperlipidemia.Therefore, fructose additive amount is limited in the present invention, and suitable fructose and maltodextrin, resistant starch are arranged in pairs or groups It uses, can prevent postprandial blood sugar from quickly increasing.Wherein, maltodextrin needs not move through the hydrolysis of ptyalin, can directly into Enter in stomach, is further digested and assimilated through small intestinal mucosa enzyme, can be relieved pipe intestinal digesting pressure.Fructose is as chemical activity in carbohydrate Highest sugar, metabolism in vivo is faster than glucose, is easy to be absorbed by organisms, and can be used as the mouth that sweetener adjusts product Sense；Resistant starch has the glucose-lipid metabolism disorder for improving diabetic, improves insulin sensitivity, antagonism or mitigation pancreas islet The effect that element is resisted, and tolerance it is good, it is edible after less there are the adverse reactions such as diarrhea, abdominal distension.
It is well known that the intake of high protein is not required in that building musculature, and the quality of protein is only Key factor.Therefore, the quality of protein decays to the synthesis of muscle protein, reduction body muscle than the supply amount of protein It is even more important.With sepg whey albumen, wheat oligopeptide, pea protein peptide, ocean fish oligopeptide and leucine etc. in the present invention High-quality protein is nitrogen source, is more advantageous to the absorption and utilization of body, can be caused by effective torsin protein matter malnutrition The negative nitrogen balance of sarcopenia patient.Wherein, hydrolyzing lactoalbumin is by hydrolyzed whey protein using protease at short The mixture of peptide and amino acid, can be directly by small intestinal absorption.Branched-chain amino acid rich in, branched-amino in lactalbumin Acid can promote muscle to synthesize, and reduce muscle breakdown, to holding and repair musculature important role.Wheat oligopeptide has Conducive to the growth of gastric epithelial cells, mitigates the denaturation of gastrointestinal mucosa epithelial cell, necrosis, maintain the structure and function of gastrointestinal mucosa Can, peomote the digestion and absorption of food ingredients.In wheat oligopeptide used in the present invention containing 25% or more paddy Glutamine (Gln).Glutamine can increase the volume of muscle cell as a kind of conditionally essential amino acid, inhibit albumen point Solution promotes muscle growth.Therefore, the present invention uses wheat oligopeptide, is providing oligopeptide easy to digest as high-quality protein source While, enough glutamine are provided for body, the synthesis of body musculature can be promoted.Leucine, as a kind of people Body essential amino acid is the important regulating and controlling factor of whole body and skeletal muscle protein synthesis.
Saturated fatty acid, the monounsaturated fatty acids that fat in special medicine purposes formula food of the present invention includes And polyunsaturated fatty acid ratio is 1:1:1.Wherein, saturated fatty acid comes from medium chain triglyceride, and medium chain triglyceride has It digests and assimilates fastly in vivo, energy is easy to the characteristics of discharging.Since medium chain triglyceride is rapid in liver metabolism, will not synthesize again Triglycerides, therefore will not be stored in liver, it is smaller to the metabolic burden of liver.
Monounsaturated fatty acids in unsaturated fatty acid is mainly from tea seed oil and rapeseed oil.The study found that tealeaves Unsaturated fatty acid content is up to 82% or more in seed oil, and wherein monounsaturated fatty acids can be adjusted effectively immune up to 50% Competent cell enhances body's immunity.Rapeseed oil mid-oleic up to 60% or more, with peanut oil, corn oil, soybean oil, Olive oil etc. is compared, and saturated fatty acid content is minimum, and contains reasonable linoleic acid plus linolenic acid, is referred to as in the world " most The edible vegetable oil of health ".Research in recent years, which shows conjugated linoleic acid (CLA), has reduction animal and body fat, increases muscle Effect.Dietary supplements be can be used as preventing muscle decaying syndrome.Fish oil is rich in EPA and DHA, is adjustable immune anti- It answers.Scientist indicates that DHA can reduce internal level of inflammation, improves the ability by tempering enhancing muscle, prevents the elderly's muscle Atrophy, prevention muscle decaying syndrome.
Chinese Soclety of Nutrition suggests, fat institute should be no more than always for the 30% of energy for energy, wherein saturated fatty acid, list Unsaturated fatty acid and polyunsaturated fatty acid institute for energy respectively account for 10% or so.In the present invention, with reference to Nutrition Society for rouge Fat energizes ratio, limits formula total lipid content, optimizes saturated fatty acid, monounsaturated fatty acids and polyunsaturated fat Sour ratio.The total fat energy supply of end formulation setting is 20% or so, at the same by medium chain triglyceride, tea seed oil, rapeseed oil, The scientific matching that fish oil, conjugated linoleic acid and phytosterin ester various plants oil carry out so that saturated fatty acid in product, it is single not Saturated fatty acid and polyunsaturated fatty acid ratio are 1:1:1.
Dietary fiber oligofructose etc. used in the present invention can be used as prebiotics and promote the growth of probiotics in enteron aisle numerous It grows, inhibits the growth of spoilage organisms, while one of protective barrier can be formed in intestinal mucosal surface, reduce to intestinal toxic substance It absorbs, intestines peristalsis can also be promoted, accelerate the discharge of intestinal toxic substance, reduce the hair of sarcopenia tients with constipation It is raw, enhance immunity of organisms.
The special medicine purposes formula food of the present invention also includes new raw-food material beta-hydroxy-Beta-methyl butyric acid Calcium (HMB-Ca) and creatine.Wherein, beta-hydroxy-β-methyl butyrate (HMB) is the metabolite of branched-chain amino acid leucine, to flesh The quality and strength of meat have improvement result, can promote the growth of muscle volume, moreover it is possible to enhance human body nitrogen fixing capacity, maintain body Internal protein is horizontal.Creatine can be synthesized in vivo by arginine, glycine and methionine.It can be by increasing phosphoric acid in muscle Creatine and glycogen, quickly increase muscle strength, promote the growth of new flesh, and accelerate fatigue recovery.
By adequately studying and literature search, the present invention are finally added to suitable vitamin and mineral in formula Matter, including macroelement, essential trace element, liposoluble vitamin and water soluble vitamin.Vitamin and mineral in the present invention The selection of matter raw material and additive amount meet " food additives use standard " (GB2760) and " food enrichment use is defended Raw standard " (GB14880) requirement.In formula, multivitamin and minerals are used cooperatively, can substance to body and Important adjustment effect is played in energetic supersession.
Specific embodiment
To make those skilled in the art more fully understand technical solution of the present invention, below with reference to embodiment to the present invention A kind of medical food and preparation method thereof of the treatment and prevention old aged muscle decaying syndrome provided is described in detail.
1. raw material feeds intake as shown in table 1:
Table 1: nutritional agents of the present invention prepares raw material
Preparation method:
(1) aniseed dissolves: the pure water of total amount 65-75% being added in dissolving tank, by solid under strong Vibratory Mixing Raw material is sequentially added into dissolving tank, so that feed liquid is flowed back uniformly by carrying out under liquid level, is uniformly dispersed in pure water, simultaneously It avoids generating excessive bubble and feed liquid layering.Nitrogen is constantly passed through into lotion in entire process for preparation.
(2) oil is mutually prepared: oils raw material and liposoluble vitamin being mixed well dissolution in order, are heated to 40-60 DEG C.
(3) 60 DEG C or so progress homogeneous homogeneous: are cooled to after water phase is mutually mixed well with oil.
It (4) will be filling after the feed liquid cooling after homogeneous.
(5) terminal sterilization: being placed in rotation for product, sterilize in fountain sterilizing cabinet, and 121 DEG C of sterilising temp, F0 value 8-12, Obtain finished product.
The purposes of special medicine purposes described in embodiment formula food is to sarcopenia mouse species experimental study
Test objective: special medicine purposes formula food described in embodiment is explored to sarcopenia mouse muscle The influence of decay
Test method: 8-10 week old C57BL/6 male mice is taken, muscle depletion syndrome is established by induced by dexamethasone Model will model successful mouse totally 30, be randomly divided into 2 groups, every group 15.Test group feeds special doctor described in embodiment Learn formula food, control group feed equal heats, etc. nitrogen quantity routine enteral nutrition emulsion.Edible dosage is 0.3g/ days, is fed daily Mouse, free water continue 21 days.
Testing index:
(1) weight and muscle quality detection: before intervention, each group mouse weight is weighed respectively and detects its muscle quality；Examination It tests after beginning and detects mouse muscle quality using Echo MRI weekly；After last time is intervened, weighs and detect muscle quality；
(2) muscle strength detects: before intervention, detecting mouse grip using grip instrument, after intervention, detects mouse again Grip；
Statistical method: being examined using t between group, and p value is less than or equal to 0.05 and thinks that the difference examined is statistically significant.
Test result:
(1) influence of the special medicine purposes formula food to mouse weight, muscle quality and weight ratio described in embodiment；
Influence (n=15, x ± s) of the special medicine purposes formula food described in 2 embodiment 1 of table to mouse weight
Note: compared with the control group, a P < 0.05
Special medicine purposes formula food described in 3 embodiment of table influences (n=to the ratio of mouse muscle quality and weight 15, x ± s)
Note: compared with the control group, a P < 0.05
(2) influence of the special medicine purposes formula food to mouse grip described in embodiment
Influence (n=15, x ± s) of the special medicine purposes formula food described in 4 embodiment of table to mouse grip
Note: compared with the control group, a P < 0.05
Result of study
(1) as shown in tables 2 and 3, before intervention, two groups of mouse weights are without significant difference (p > 0.05)；After intervention, test group Mouse weight is significantly higher than control group weight (P < 0.05)；As shown in table 2, after excluding weight influence, the muscle quality of test group It is significantly higher than the ratio (P < 0.05) of control group muscle quality and weight with the ratio of weight；Show the special full nutrient formulation Food can provide sufficient nutrition for mouse, increase its weight, while can increase the muscle mass of body；
(2) as shown in table 4, control group and test group mouse grip all increased after intervention, illustrate that nutritional supplementation can Improve the muscle strength of sarcopenia mouse；And after intervening, the grip of test group mouse is shown compared with control group group It writes and increases, illustrate that special medicine purposes formula food described in the embodiment can effectively improve the muscle strength of mouse.
In conclusion the experiment show the special medicine purposes formula food compared with commercially available common enteral nutrition product, The nutrition condition of body can not only preferably be improved, additionally it is possible to which the effective muscle mass for increasing sarcopenia mouse is controlled Muscle decay is treated and slowed down, the recovery of sarcopenia patient is facilitated.
Specific description of embodiments of the present invention above is not intended to limit the present invention, therefore is not departing from overall structure of the invention Change and modification under thinking, should belong within protection scope of the present invention.

Claims (10)

1. a kind of medical food for treating and preventing old aged muscle decaying syndrome, which is characterized in that press the medical food 1000ml meter, include: protein 56-82g, fat 20-31g, carbohydrate 110-160g, dietary fiber 10.5-16.2g, Beta-hydroxy-methylbutanoic acid calcium 0.9-1.6g, creatine 2.2-3.2g, vitamin 1.5-2.6g, minerals 20-30g and water 690- 800g；
Wherein, the protein include hydrolyzing lactoalbumin 22-36g, pea protein peptide 13-20g, wheat oligopeptide 13-20g, Ocean fish oligopeptide powder 4.2-6.5g, leucine 1.6-2.5g；
The fat is sub- comprising medium chain triglyceride 7.2-11.5g, tea seed oil 5.5-8.5g, rapeseed oil 4.5-7.0g, conjugation Oleic acid 1.5-2.5g, fish oil 2.0-3.5g；
The carbohydrate includes maltodextrin 70-105g, fructose 22-35g, resistant starch 13-20g；
The vitamin includes vitamin A 3.1-4.5mg, vitamin C 1.1-1.58g, vitamin D316.5-24 μ g, dimension life Plain E 55-82mg, vitamin K11142-205 μ g, vitamin B14.2-6.5mg, vitamin B25.6-8.2mg, vitamin B6 5.6-8.2mg, pantothenic acid 13.9-21.2mg, biotin 8.5-12.5mg, folic acid 7.5-10.5mg, niacinamide 19.5-28.2mg, Vitamin B126.2-8.9ug, choline 330-479mg；
The minerals include calcium chloride 2.4-3.6g, potassium hydroxide 0.3-0.49g, potassium citrate 0.96-1.55g, phosphoric acid hydrogen Dipotassium 3.3-5.2g, sodium citrate 4.0-6.5g, magnesium chloride 2.1-3.2g, six hydrated chromium trichloride 13.5-18.6mg, glucose Sour copper 18.2-28.5mg, three hydration ferrous lactate 80.5-118.2mg, Manganous sulfate monohydrate 11.2-17.9mg, two molybdic acid hydrates Sodium 7.5-11.6mg, sodium selenite 26.6-40.2mg, Zinc sulfate monohydrate 40.9-60.5mg, 10% potassium iodide 2.8-4.2g.
2. the medical food according to claim 1 for treating and preventing old aged muscle decaying syndrome, which is characterized in that institute Stating and treating and preventing the medical food of old aged muscle decaying syndrome includes protein 65g, fat 34.5g, carbohydrate 126g, dietary fiber 12.4g, vitamin 2.0g, minerals 24g, water 770g.
3. the medical food according to claim 2 for treating and preventing old aged muscle decaying syndrome, which is characterized in that institute Stating protein includes hydrolyzing lactoalbumin 28g, pea protein peptide 15.2g, wheat oligopeptide 15.2g, leucine 2.0g.
4. the medical food according to claim 3 for treating and preventing old aged muscle decaying syndrome, which is characterized in that institute It states fat and includes medium chain triglyceride 8.5g, tea seed oil 6.5g, rapeseed oil 5.3g, conjugated linoleic acid 1.9g, fish oil 2.5g.
5. the medical food according to claim 4 for treating and preventing old aged muscle decaying syndrome, which is characterized in that institute Stating carbohydrate includes maltodextrin 85g, fructose 26g, resistant starch 15g；The treatment and prevention old aged muscle decaying The medical food of syndrome also includes oligofructose 3.6g, xylo-oligosaccharide 3.6g, isomaltose 12.4g.
6. the medical food according to claim 5 for treating and preventing old aged muscle decaying syndrome, which is characterized in that institute Stating vitamin includes vitamin A 3.62mg, vitamin C 1.26g, vitamin D319.2 μ g, vitamin E 64mg, vitamin K1 160 μ g, vitamin B14.8mg, vitamin B26.4mg, vitamin B66.4mg, pantothenic acid 16.64mg, biotin 9.6mg, leaf Sour 8.0ug, niacinamide 22.4mg, vitamin B127.04 μ g, choline 380mg.
7. the medical food according to claim 6 for treating and preventing old aged muscle decaying syndrome, which is characterized in that institute State minerals include calcium chloride 2.8g, potassium hydroxide 0.4g, potassium citrate 1.2g, dipotassium hydrogen phosphate 4.0g, sodium citrate 5.0g, Magnesium chloride 2.5g, six hydrated chromium trichloride 14.35mg, copper gluconate 21.25mg, three hydration ferrous lactate 93.85mg, a water Close manganese sulfate 14.0mg, two molybdic acid hydrate sodium 8.83mg, sodium selenite 32.2mg, Zinc sulfate monohydrate 48.03mg, 10% iodate Potassium 3.3g.
8. the medical food according to claim 7 for treating and preventing old aged muscle decaying syndrome, which is characterized in that institute Stating and treating and preventing the medical food of old aged muscle decaying syndrome includes beta-hydroxy-methylbutanoic acid calcium 1.2g and creatine 2.5g.
9. the medical food according to claim 8 for treating and preventing old aged muscle decaying syndrome, which is characterized in that institute Stating and treating and preventing nutritional agents described in the medical food of old aged muscle decaying syndrome includes emulsifier soybean lecithin 1.1-1.8g, Acidity regulator citric acid 1.7-2.6g, colorant natural Beta-carotene 0.7-1.2g.
10. a kind of prepare treats and prevents the medical of old aged muscle decaying syndrome described in any one in claim 1 to 9 Food, which comprises the following steps:
(1) aniseed dissolves: the pure water of total amount 65%-75% being added in dissolving tank, by solid original under strong Vibratory Mixing Material is sequentially added into dissolving tank, so that feed liquid is flowed back uniformly by carrying out under liquid level, is uniformly dispersed in pure water, keeps away simultaneously Exempt to generate excessive bubble and feed liquid layering, is constantly passed through nitrogen into lotion in entire process for preparation；
(2) oil is mutually prepared: oils raw material and liposoluble vitamin being mixed well dissolution in order, are heated to 40-60 DEG C；
(3) 60 DEG C or so progress homogeneous homogeneous: are cooled to after water phase is mutually mixed well with oil；
It (4) will be filling after the feed liquid cooling after homogeneous；
(5) terminal sterilization: product is placed in rotation, is sterilized in fountain sterilizing cabinet, 121 DEG C of sterilising temp, F0 value 8-12 is obtained Finished product.
CN201810791304.2A 2018-07-18 2018-07-18 A kind of medical food and preparation method thereof treating and preventing old aged muscle decaying syndrome Pending CN109077302A (en)

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CN109527585A (en) * 2018-12-26 2019-03-29 浙江华康药业股份有限公司 A kind of alimentation composition and preparation method thereof that can prevent gentle expelling pathogenic factors from muscles and skin and lack disease
CN110037297A (en) * 2019-05-14 2019-07-23 宁波特壹食品有限公司 A kind of formula powder and preparation method thereof of suitable sarcopenia
CN111035017A (en) * 2019-12-12 2020-04-21 山东省药学科学院 Oral liquid for preventing and treating muscle loss
CN112155057A (en) * 2020-08-25 2021-01-01 石家庄君乐宝乳业有限公司 High-protein thickened modified milk powder and preparation method thereof
CN115177000A (en) * 2021-04-07 2022-10-14 陕西罗麻丹医药有限公司 Powder for improving sarcopenia of old people and preparation method thereof
CN113412936A (en) * 2021-07-14 2021-09-21 复旦大学附属中山医院 Enteral nutrition preparation for sarcopenia patients
CN114304287A (en) * 2022-01-06 2022-04-12 江南大学 Fat component used in medical formula food for sarcopenia syndrome, preparation method and application
CN114304287B (en) * 2022-01-06 2023-01-24 江南大学 Fat component used in medical formula food for sarcopenia syndrome, preparation method and application
CN114431380A (en) * 2022-02-25 2022-05-06 广东君悦营养医学有限公司 Protein water suitable for muscle attenuation syndrome and preparation method thereof
CN114680339A (en) * 2022-04-12 2022-07-01 天津医科大学 Nutritional supplement for improving muscle attenuation and delaying senescence and application thereof

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