CN107440088A - Improve operation, the nutrients and preparation method thereof of chemicotherapy tumor patient immunity - Google Patents
Improve operation, the nutrients and preparation method thereof of chemicotherapy tumor patient immunity Download PDFInfo
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- CN107440088A CN107440088A CN201610379903.4A CN201610379903A CN107440088A CN 107440088 A CN107440088 A CN 107440088A CN 201610379903 A CN201610379903 A CN 201610379903A CN 107440088 A CN107440088 A CN 107440088A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses it is a kind of improve operation, chemicotherapy tumor patient immunity nutrients and preparation method thereof, belong to the technical field of medical food.The present invention includes the 98g/L of protein 45,22 48g/L of fat, the 245g/L of carbohydrate 98, the 18g/L of dietary fiber 0, the 0.75g/L of vitamin 0.35,3.6 7.2g/L of trace element, the 2.2g/L of nucleotides 1.0, the 20g/L of arginine 0.2, the 0.2g/L of taurine 0, appropriate amount of water.The present invention has multiple nutritional components; rich in glutamine, arginine, nucleotides, omega-3 fatty acid etc.; matching science, the nutrition condition of patient is improved, enhance corrective surgery and the tolerance of postoperative, radiotherapy and chemotherapy; improve the immunity of organisms of patient; acute inflammatory response is controlled, protects function of intestinal mucosa barrier in patient, reduces complication; shorten hospital day, reduce medical expense.
Description
Technical field
The invention belongs to the technical field of medical food, particularly relate to it is a kind of improve operation, the nutrients and preparation method thereof of chemicotherapy tumor patient immunity, in particular to it is a kind of improve patient with operation, the nutrients of chemicotherapy tumor patient immunity combines and preparation method thereof.
Background technology
" when stomach and intestine allow, should try one's best and use enteral nutrition ", this basic principle that should be observed when turning into modern clinic nutritional support.EN support is simple, effective, cheap, is the preferred approach of peri-operation period nutritional support.Peri-operation period, to improving nutritional status, is improved immunologic function, it is significant to reduce postoperative complications using enteral nutrition preparation；Very there is scholar's proposition：Perioperative enteral nutrition has irreplaceable effect to patients with gastrointestinal.
At present, the enteral nutrition preparation for patients during peri has that scholar is strong, just first board complex peptides special diet nutrient solution, more Tongrentang's board small peptide food of special nutrients, element etc..Scholar's persistent erection nutritional ingredient is more comprehensive, and still, its protein source is single, comprises only hydrolyzed wheat protein and casein；Three kinds using Isin glue collagen peptide as a kind of albumen source afterwards, adds the raw material of protein, still, it can not adjust the immunocompetence of patient.
Meanwhile be orally that optimal enteral nutrition gives approach, this mode best suits the physilogical characteristics of patient, and patient is acceptant, and compliance is good, is most widely used.Currently, the enteral nutrition preparation of patients during peri on the market is in the majority with pulvis, and liquid dosage form is less, and the technical difficulty for being primarily due to liquid dosage form preparation is larger.But oral liquid has the advantages that taking dose is small, absorbs very fast, steady quality, be easy to carry and use, easy to maintain, is favored by patient.
The content of the invention
The present invention provide it is a kind of improve operation, the nutrients and preparation method thereof of chemicotherapy tumor patient immunity, solve the problems, such as patients during peri in the prior art enteral nutrition preparation take it is inconvenient, absorb slow and not comprehensive nutrition and can not fully adjust patient's immunity.
A kind of raising operation of the present invention, the nutrients of chemicotherapy tumor patient immunity, what it was mainly realized by the following technical programs：Nutrients described in per 100mL includes the composition of following parts by weight：Protein 4.5-9.8g, fatty 2.2-4.8g, carbohydrate 9.8-24.5g, dietary fiber 0-1.80g, vitamin 0.035-0.075g, mineral trace element 0.36-0.72g, nucleotides 0.10-0.22g, arginine 0.02-2.0g, taurine 0-0.02g, appropriate amount of water.
Present invention encompasses multiple nutritional components, by by protein, fat, carbohydrate, dietary fiber, micro-element, mineral trace element, nucleotides, the combination of arginine and taurine, the nutrients is set to be rich in glutamine, arginine, nucleotides, omega-fatty acid etc., each nutritional ingredient matches by science, carry out enteral nutrition supplement within 5-7 days and postoperative lasting 5-7 days before surgery, improve the nutrition condition of patient, enhance corrective surgery and postoperative, radiotherapy and the tolerance of chemotherapy, improve the immunity of organisms of patient, acute inflammatory response can be controlled, protect function of intestinal mucosa barrier in patient, reduce complication, shorten hospital day, reduce medical expense；Suitable for receiving neck major operation because of tumour（Such as laryngectomy, pharyngectomy）Patient, abdominal tumor major operation（Esophagectomy, gastrectomy and pancreatoduodenectomy）Patient, severe trauma patients peri-operation period EN support.
As a kind of preferred embodiment, the mineral trace element includes the element of following parts by weight：Calcium 64-144mg, phosphorus 64-120mg, potassium 128-228mg, sodium 76.8-180mg, magnesium 21.6-38.4mg, iron 0.96-2.16mg, zinc 1.2-2.6mg, iodine 8-25 μ g, selenium 5.4-12.0 μ g, copper 0.14-0.30mg, manganese 0.16-0.35mg；The raw material of the calcium is calcium monohydrogen phosphate, one or both of calcium carbonate, the raw material of the phosphorus is calcium monohydrogen phosphate, potassium dihydrogen phosphate, one or more in sodium dihydrogen phosphate, the raw material of the potassium is potassium chloride, potassium dihydrogen phosphate, one or more in potassium citrate, the raw material of the sodium is sodium citrate, one or more in sodium dihydrogen phosphate, the raw material of the magnesium is magnesium carbonate, one or both of magnesium chloride, the raw material of the iron is ferric pyrophosphate, one or both of ferrous sulfate, the raw material of the zinc is zinc sulfate, the raw material of the iodine is sodium iodide, KI, one or more in Potassiumiodate, the raw material of the selenium is sodium selenite, the raw material of the copper is copper sulphate, the raw material of the manganese is manganese sulfate, one or both of manganese chloride.By the addition of mineral trace element, a large amount of losses in time supplemented with patient's body mineral trace element caused during operation and postoperative, radiotherapy and chemotherapy；This mineral trace element is added in a manner of corresponding compound, and the dosage of corresponding compound is converted into the content of corresponding trace element.
As a kind of preferred embodiment, the vitamin includes the composition of following parts by weight：Vitamin A 160-289 μ gRE, vitamin D
1.0-2.0 μ g, vitamin E
4.5-7.5mg α-TE, vitamin B1
0.14-0.24mg, vitamin B2 0.14-0.3mg, vitamin B6 0.12-0.25mg, vitamin B12
0.64-1.0 μ g, vitamin C
6.4-10.0mg, nicotinic acid 1.6-2.7mg, folic acid 22-48 μ g, pantothenic acid 0.55-1.5mg, biotin 8-24 μ g, choline 21-48mg.Here the content of vitamin A uses retinol equivalent（RE）Metering, the content of vitamin E use alpha-tocopherol equivalent（α-TE）Metering, the addition of a variety of micro-elements, supplements vitamin lacking in patient body in time.
As a kind of preferred embodiment, the fat is made up of the fish oil powder of the vegetable oil of 1.75-2.35 parts by weight, the medium chain triglyceride of 0.1-0.2 parts by weight and 1.75-2.35 parts by weight, the fish oil powder is the deep-sea fish oil-bound distemper of microencapsulation, the deep-sea fish oil-bound distemper is the one or more in mackerel fish oil powder, catfish fish oil powder, sardine fish oil powder, tuna oil powder, and the vegetable oil is the one or more in high oleic sunflower oil, olive oil, corn oil, sunflower oil.This compound fat provides polyunsaturated fatty acid and saturated fatty acid, and this deep-sea fish oil-bound distemper is rich in omega-fatty acid, and which employs microcapsules technology, while EPA/DHA is provided, completely without fishlike smell, improves patient compliance, ensures products taste.
As a kind of preferred embodiment, the protein is the one or more in animal protein, vegetable protein, and the animal protein is one or both of lactalbumin, casein, and the vegetable protein is one or both of soybean protein, wheat gluten.The protein source of the present invention is more, and animal protein, vegetable protein can be applied in combination, and enriches the species of protein.
As a kind of preferred embodiment, the protein is made up of lactalbumin, casein and sea cucumber peptide, the addition of lactalbumin at least accounts for the 50% of total protein in the protein, and the addition of sea cucumber peptide is 1-20g/L, and the mean molecule quantity of the sea cucumber peptide is no more than 5000Da.Sea cucumber peptide refers to the small-molecular peptides that sea cucumber obtains after protease hydrolytic and separating-purifying, mainly collagen peptides；This micromolecule polypeptide has multiple efficacies composition, it is irreplaceable to be played the role of other nutriments by such as lowering blood pressure and blood fat, antiatherosclerosis, antifatigue, antibacterial, raising immunity, anti-aging and anti-oxidant many physiological functions for human physiological functions.
As a kind of preferred embodiment, the carbohydrate is one or both of maltodextrin, sucrose, and the dietary fiber is FOS, soybean fiber, Arabic gum, inulin, the one or more of microcrystalline cellulose.The addition of dietary fiber can optionally stimulate one or more of colons are endogenous to occupy bacteria growing, the original of increase human body intestinal canal occupies bacterium such as Bacillus acidi lactici, Bifidobacterium, competed with enteral pathogenic bacteria, reduce the undue growth of pathogenic bacteria, the glycolysis efficiency of enteric bacteria is improved to improve intestinal environment, is finally reached the purpose for safeguarding intestinal microecology and gut barrier function.
As a kind of preferred embodiment, the formulation of the nutrients is liquid dosage form, and the nutrients also includes emulsifying agent 0.10-0.30g, stabilizer 0.015-0.040g, sweetener 0-0.15g and essence 0-0.50g.This liquid dosage form nutrients is a kind of liquid oral liquid, have the advantages that taking dose is small, absorbs very fast, steady quality, be easy to carry and use, easy to maintain, and in the presence of sweetener and essence, optimal mouthfeel is mixed, fully to meet the needs of patient.
A kind of raising operation of the present invention, the preparation method of the nutrients of chemicotherapy tumor patient immunity, what it was mainly realized by the following technical programs：Comprise the following steps：1）Dietary fiber is taken, stabilizer is added, is dissolved in more than 70 DEG C of water-bath, forms solution, it is standby；2）In preparing tank, the part water for the 60-80% for accounting for water inventory is added, in the presence of strong agitation, carbohydrate, protein, the raw material of mineral trace element, nucleotides, arginine and taurine is added, disperses, obtain aqueous phase；3）By step 1）Resulting solution is added to step 2）In gained aqueous phase, under the protective effect of inert gas, the water-soluble material and sweetener that add in vitamin, aqueous mixture is formed；4）Fat is taken, under the protective effect of inert gas, the fat-soluble raw material in emulsifying agent and vitamin is added, shears 3-7min, form oil mixture；5）By step 4）Gained oil mixture and step 3）Gained aqueous mixture mixes, and under the protective effect of inert gas, shearing, colostrum is made；6）By step 5）Gained colostrum, under the protective effect of inert gas, remaining water is added, regulation pH value is 6.5-7.5, is stirred, and is well mixed, and removes bubble, obtains mixed liquor；7）In step 6）Essence is added in gained mixed liquor, then, progress is high-pressure homogeneous, and is cooled to 20-30 DEG C, canned, obtains head product；8）By step 7）Gained head product, sterilized at 115-121 DEG C, F0 values are 10-16, produce product.
The present invention by dietary fiber high-temperature digestion, water-soluble substances by being made aqueous mixture, oil mixture is made in oil soluble material; under the protective effect of inert gas; using strong stirring, high speed shear and high pressure homogenization technique; it is dispersed in pure water to be advantageous to all the components; it ensure that the particle diameter of product is small and be uniformly distributed; it ensure that the stability of product; avoid oxidizable composition in product and oxidation reaction occur; it effectively prevent constituent part to decompose or destroy because heated excessive or uneven, fully ensured that the performance of product.
As a kind of preferred embodiment, the fat-soluble raw material in the vitamin includes Retinol Palmitate, vitamin D, alpha-tocopherol acetate；Water-soluble material in the cellulose includes thiamine hydrochloride, Riboflavine sodium phosphate, hydrochloric acid pyrrole and trembled zinc, vitamin B12, vitamin C, nicotinic acid, folic acid, calcium pantothenate, biotin, Choline Chloride；The step 7）In, the product after cooling is filled in Brown Glass Brown glass bottles and jars only or lucifuge and the high bag of barrier；The step 8）In, sterilizing is carried out in rotating type sterilization cabinet.A variety of micro-elements are provided by above-mentioned raw materials, and these micro-element raw material sources are easy, are taken conveniently.
Beneficial effects of the present invention：Present invention encompasses multiple nutritional components; rich in glutamine, arginine, nucleotides, omega-fatty acid etc.; matched by science, improve the nutrition condition of patient, enhance corrective surgery and the tolerance of postoperative, radiotherapy and chemotherapy; improve the immunity of organisms of patient; acute inflammatory response is controlled, protects function of intestinal mucosa barrier in patient, reduces complication; hospital day is shortened, reduces medical expense；Its is in good taste, no fishlike smell, convenient to take, absorbs fast, steady quality；Its preparation process avoids oxidizable composition in product and oxidation reaction occurs, effectively prevent constituent part and decomposes or destroy because heated excessive or uneven, has fully ensured that the performance of product.
Embodiment
Technical scheme is clearly and completely described below in conjunction with the specific embodiment of the present invention, it is clear that described embodiment is only the part of the embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made belongs to the scope of protection of the invention.
A kind of raising operation of the present invention, the nutrients of chemicotherapy tumor patient immunity, nutrients described in per 100mL include the composition of following parts by weight：Protein 4.5-9.8g, fatty 2.2-4.8g, carbohydrate 9.8-24.5g, dietary fiber 0-1.80g, vitamin 0.035-0.075g, mineral trace element 0.36-0.72g, nucleotides 0.10-0.22g, arginine 0.02-2.0g, taurine 0-0.02g, appropriate amount of water.
Specifically, the mineral trace element includes the element of following parts by weight：Calcium 64-144mg, phosphorus 64-120mg, potassium 128-228mg, sodium 76.8-180mg, magnesium 21.6-38.4mg, iron 0.96-2.16mg, zinc 1.2-2.6mg, iodine 8-25 μ g, selenium 5.4-12.0 μ g, copper 0.14-0.30mg, manganese 0.16-0.35mg；The raw material of the calcium is calcium monohydrogen phosphate, one or both of calcium carbonate, the raw material of the phosphorus is calcium monohydrogen phosphate, potassium dihydrogen phosphate, one or more in sodium dihydrogen phosphate, the raw material of the potassium is potassium chloride, potassium dihydrogen phosphate, one or more in potassium citrate, the raw material of the sodium is sodium citrate, one or more in sodium dihydrogen phosphate, the raw material of the magnesium is magnesium carbonate, one or both of magnesium chloride, the raw material of the iron is ferric pyrophosphate, one or both of ferrous sulfate, the raw material of the zinc is zinc sulfate, the raw material of the iodine is sodium iodide, KI, one or more in Potassiumiodate, the raw material of the selenium is sodium selenite, the raw material of the copper is copper sulphate, the raw material of the manganese is manganese sulfate, one or both of manganese chloride.
Further, the vitamin includes the composition of following parts by weight：Vitamin A 160-289 μ gRE, vitamin D
1.0-2.0 μ g, vitamin E
4.5-7.5mg α-TE, vitamin B1
0.14-0.24mg, vitamin B2 0.14-0.3mg, vitamin B6 0.12-0.25mg, vitamin B12
0.64-1.0 μ g, vitamin C
6.4-10.0mg, nicotinic acid 1.6-2.7mg, folic acid 22-48 μ g, pantothenic acid 0.55-1.5mg, biotin 8-24 μ g, choline 21-48mg.
More specifically, the fat is made up of the fish oil powder of the vegetable oil of 1.75-2.35 parts by weight, the medium chain triglyceride of 0.1-0.2 parts by weight and 1.75-2.35 parts by weight, the fish oil powder is the deep-sea fish oil-bound distemper of microencapsulation, the deep-sea fish oil-bound distemper is the one or more in mackerel fish oil powder, catfish fish oil powder, sardine fish oil powder, tuna oil powder, and the vegetable oil is the one or more in high oleic sunflower oil, olive oil, corn oil, sunflower oil.
Further, the protein is the one or more in animal protein, vegetable protein, and the animal protein is one or both of lactalbumin, casein, and the vegetable protein is one or both of soybean protein, wheat gluten.
Preferably, the protein is made up of lactalbumin, casein and sea cucumber peptide, and the addition of lactalbumin at least accounts for the 50% of total protein in the protein, and the addition of sea cucumber peptide is 1-20g/L, and the mean molecule quantity of the sea cucumber peptide is no more than 5000Da.
Specifically, the carbohydrate is one or both of maltodextrin, sucrose, and the dietary fiber is FOS, soybean fiber, Arabic gum, inulin, the one or more of microcrystalline cellulose.
Yet further, the formulation of the nutrients is liquid dosage form, and the nutrients also includes emulsifying agent 0.10-0.30g, stabilizer 0.015-0.040g, sweetener 0-0.15g and essence 0-0.50g.
A kind of raising operation of the present invention, the preparation method of the nutrients of chemicotherapy tumor patient immunity, comprise the following steps：1）Dietary fiber is taken, stabilizer is added, is dissolved in more than 70 DEG C of water-bath, forms solution, it is standby；2）In preparing tank, the part water for the 60-80% for accounting for water inventory is added, in the presence of strong agitation, carbohydrate, protein, the raw material of mineral trace element, nucleotides, arginine and taurine is added, disperses, obtain aqueous phase；3）By step 1）Resulting solution is added to step 2）In gained aqueous phase, under the protective effect of inert gas, the water-soluble material and sweetener that add in vitamin, aqueous mixture is formed；4）Fat is taken, under the protective effect of inert gas, the fat-soluble raw material in emulsifying agent and vitamin is added, shears 3-7min, form oil mixture；5）By step 4）Gained oil mixture and step 3）Gained aqueous mixture mixes, and under the protective effect of inert gas, shearing, colostrum is made；6）By step 5）Gained colostrum, under the protective effect of inert gas, remaining water is added, regulation pH value is 6.5-7.5, is stirred, and is well mixed, and removes bubble, obtains mixed liquor；7）In step 6）Essence is added in gained mixed liquor, then, progress is high-pressure homogeneous, and is cooled to 20-30 DEG C, canned, obtains head product；8）By step 7）Gained head product, sterilized at 115-121 DEG C, F0 values are 10-16, produce product.
Further, the fat-soluble raw material in the vitamin includes Retinol Palmitate, vitamin D, alpha-tocopherol acetate；Water-soluble material in the cellulose includes thiamine hydrochloride, Riboflavine sodium phosphate, hydrochloric acid pyrrole and trembled zinc, vitamin B12, vitamin C, nicotinic acid, folic acid, calcium pantothenate, biotin, Choline Chloride；The step 7）In, the product after cooling is filled in Brown Glass Brown glass bottles and jars only or lucifuge and the high bag of barrier；The step 8）In, sterilizing is carried out in rotating type sterilization cabinet.
Embodiment one
A kind of raising operation of the present invention, the nutrients of chemicotherapy tumor patient immunity are prepared by the following method.
（1）The raw material used in 1000mL nutrients is weighed according to the dosage described in first row in table 1；
（2）Dietary fiber is taken, stabilizer is added, under high temperature（In i.e. more than 70 DEG C of water-bath）Dissolving, solution is formed, it is standby；
（3）Take water 800g at room temperature, in preparing tank, add 500g water; in the presence of strong agitation, by blender, by carbohydrate, protein, the raw material of mineral trace element, nucleotides, arginine and taurine; it is dissolved or dispersed in pure water, obtains aqueous phase；
（4）Above-mentioned solution is added in above-mentioned aqueous phase, under the protective effect of nitrogen, the water-soluble material and sweetener that add in vitamin, forms aqueous mixture；
（5）Fat is taken, under the protective effect of nitrogen, the fat-soluble raw material in emulsifying agent and vitamin is added, shears 3min, form oil mixture；
（6）Above-mentioned oil mixture is mixed through oil pump and above-mentioned aqueous mixture, under the protective effect of nitrogen, shearing, colostrum is made；
（7）By above-mentioned colostrum, under the protective effect of nitrogen, remaining water is added, adds regulating acid agent, regulation pH value is 6.5, stirs, is well mixed, and removes bubble, obtains mixed liquor；
（8）Essence is added in above-mentioned mixed liquor, then, carries out high-pressure homogeneous, and is cooled to 20 DEG C, it is canned, in auto-filling to Brown Glass Brown glass bottles and jars only or lucifuge and the high bag of barrier, obtain head product；
9）By above-mentioned head product, insert in rotary steam sterilizing cabinet and sterilize, sterilized at 121 DEG C, F0 values are 10, produce product.
Wherein, the raw material of manganese is manganese sulfate, and the raw material of copper is copper sulphate, and the raw material of selenium is sodium selenite, the raw material of iodine is sodium iodide, the raw material of zinc is zinc sulfate, and the raw material of iron is ferric pyrophosphate, and the raw material of magnesium is magnesium carbonate, the raw material of calcium is calcium monohydrogen phosphate and calcium carbonate, the raw material of potassium is potassium chloride and potassium dihydrogen phosphate, and the raw material of sodium is sodium selenite, sodium iodide, sodium dihydrogen phosphate and sodium citrate, and the raw material of phosphorus is ferric pyrophosphate, calcium monohydrogen phosphate, potassium dihydrogen phosphate and sodium dihydrogen phosphate；
Fat-soluble raw material in vitamin includes Retinol Palmitate（VA）, vitamin D, alpha-tocopherol acetate（VE）, the water-soluble material in cellulose includes thiamine hydrochloride（VB1）, Riboflavine sodium phosphate（VB2）, hydrochloric acid pyrrole trembles zinc（VB6）, vitamin B12, vitamin C, nicotinic acid, folic acid, calcium pantothenate, biotin, Choline Chloride；
Fat is made up of the deep-sea fish oil-bound distemper of the microencapsulation of the vegetable oil of 1.75 parts by weight, the medium chain triglyceride of 0.1 parts by weight and 1.75 parts by weight, protein is the one or more in animal protein, vegetable protein, carbohydrate is one or both of maltodextrin, sucrose, and dietary fiber is FOS, soybean fiber, Arabic gum, inulin, the one or more of microcrystalline cellulose.
Embodiment two
A kind of raising operation of the present invention, the nutrients of chemicotherapy tumor patient immunity are prepared by the following method.
（1）The raw material used in 1000mL nutrients is weighed according to the dosage described in secondary series in table 1；
（2）Dietary fiber is taken, stabilizer is added, under high temperature（In i.e. more than 70 DEG C of water-bath）Dissolving, solution is formed, it is standby；
（3）Take water 850g at room temperature, in preparing tank, add 700g water, in the presence of strong agitation, by blender, by carbohydrate, protein, mineral trace element raw material（Sodium citrate, potassium chloride, sodium dihydrogen phosphate, potassium dihydrogen phosphate, zinc sulfate, magnesium carbonate, ferric pyrophosphate, manganese sulfate, calcium carbonate, calcium monohydrogen phosphate, sodium iodide, copper sulphate, sodium selenite）, nucleotides, arginine and taurine, be dissolved or dispersed in pure water, obtain aqueous phase；
（4）Above-mentioned solution is added in above-mentioned aqueous phase, under the protective effect of nitrogen, the water-soluble material and sweetener that add in vitamin, forms aqueous mixture；
（5）Fat is taken, under the protective effect of nitrogen, the fat-soluble raw material in emulsifying agent and vitamin is added, shears 7min, form oil mixture；
（6）Above-mentioned oil mixture is mixed through oil pump and above-mentioned aqueous mixture, under the protective effect of nitrogen, shearing, colostrum is made；
（7）By above-mentioned colostrum, under the protective effect of nitrogen, remaining water is added, adds regulating acid agent, regulation pH value is 7.5, stirs, is well mixed, and removes bubble, obtains mixed liquor；
（8）Essence is added in above-mentioned mixed liquor, then, carries out high-pressure homogeneous, and is cooled to 30 DEG C, it is canned, in auto-filling to Brown Glass Brown glass bottles and jars only or lucifuge and the high bag of barrier, obtain head product；
9）By above-mentioned head product, insert in rotary steam sterilizing cabinet and sterilize, sterilized at 115 DEG C, F0 values are 16, produce product.
Wherein, the raw material of manganese is manganese sulfate, and the raw material of copper is copper sulphate, and the raw material of selenium is sodium selenite, the raw material of iodine is sodium iodide, the raw material of zinc is zinc sulfate, and the raw material of iron is ferric pyrophosphate, and the raw material of magnesium is magnesium carbonate, the raw material of calcium is calcium monohydrogen phosphate and calcium carbonate, the raw material of potassium is potassium chloride and potassium dihydrogen phosphate, and the raw material of sodium is sodium selenite, sodium iodide, sodium dihydrogen phosphate and sodium citrate, and the raw material of phosphorus is ferric pyrophosphate, calcium monohydrogen phosphate, potassium dihydrogen phosphate and sodium dihydrogen phosphate；
Fat-soluble raw material in vitamin includes Retinol Palmitate（VA）, vitamin D, alpha-tocopherol acetate（VE）, the water-soluble material in cellulose includes thiamine hydrochloride（VB1）, Riboflavine sodium phosphate（VB2）, hydrochloric acid pyrrole trembles zinc（VB6）, vitamin B12, vitamin C, nicotinic acid, folic acid, calcium pantothenate, biotin, Choline Chloride；
Fat is made up of the mackerel fish oil powder of the microencapsulation of the vegetable oil of 2.00 parts by weight, the medium chain triglyceride of 0.15 parts by weight and 2.00 parts by weight, protein is that animal protein and vegetable protein form, carbohydrate is one or both of maltodextrin, sucrose, and dietary fiber is FOS, soybean fiber, Arabic gum, inulin, the one or more of microcrystalline cellulose.
Embodiment three
A kind of raising operation of the present invention, the nutrients of chemicotherapy tumor patient immunity are prepared by the following method.
（1）The raw material used in 1000mL nutrients is weighed according to the described dosage of the 3rd row in table 1；
（2）Dietary fiber is taken, stabilizer is added, under high temperature（In i.e. more than 70 DEG C of water-bath）Dissolving, solution is formed, it is standby；
（3）Take water 820g at room temperature, in preparing tank, add 600g water, in the presence of strong agitation, by blender, by carbohydrate, protein, mineral trace element raw material（Sodium citrate, potassium chloride, sodium dihydrogen phosphate, potassium dihydrogen phosphate, zinc sulfate, magnesium carbonate, ferric pyrophosphate, manganese sulfate, calcium carbonate, calcium monohydrogen phosphate, sodium iodide, copper sulphate, sodium selenite）, nucleotides, arginine and taurine, be dissolved or dispersed in pure water, obtain aqueous phase；
（4）Above-mentioned solution is added in above-mentioned aqueous phase, under the protective effect of nitrogen, the water-soluble material and sweetener that add in vitamin, forms aqueous mixture；
（5）Fat is taken, under the protective effect of nitrogen, the fat-soluble raw material in emulsifying agent and vitamin is added, shears 5min, form oil mixture；
（6）Above-mentioned oil mixture is mixed through oil pump and above-mentioned aqueous mixture, under the protective effect of nitrogen, shearing, colostrum is made；
（7）By above-mentioned colostrum, under the protective effect of nitrogen, remaining water is added, adds regulating acid agent, regulation pH value is 7.0, stirs, is well mixed, and removes bubble, obtains mixed liquor；
（8）Essence is added in above-mentioned mixed liquor, then, carries out high-pressure homogeneous, and is cooled to 25 DEG C, it is canned, in auto-filling to Brown Glass Brown glass bottles and jars only or lucifuge and the high bag of barrier, obtain head product；
（9）By above-mentioned head product, insert in rotary steam sterilizing cabinet and sterilize, sterilized at 120 DEG C, F0 values are 15, produce product.
Wherein, the raw material of manganese is manganese sulfate, and the raw material of copper is copper sulphate, and the raw material of selenium is sodium selenite, the raw material of iodine is sodium iodide, the raw material of zinc is zinc sulfate, and the raw material of iron is ferric pyrophosphate, and the raw material of magnesium is magnesium carbonate, the raw material of calcium is calcium monohydrogen phosphate and calcium carbonate, the raw material of potassium is potassium chloride and potassium dihydrogen phosphate, and the raw material of sodium is sodium selenite, sodium iodide, sodium dihydrogen phosphate and sodium citrate, and the raw material of phosphorus is ferric pyrophosphate, calcium monohydrogen phosphate, potassium dihydrogen phosphate and sodium dihydrogen phosphate；
Fat-soluble raw material in vitamin includes Retinol Palmitate（VA）, vitamin D, alpha-tocopherol acetate（VE）, the water-soluble material in cellulose includes thiamine hydrochloride（VB1）, Riboflavine sodium phosphate（VB2）, hydrochloric acid pyrrole trembles zinc（VB6）, vitamin B12, vitamin C, nicotinic acid, folic acid, calcium pantothenate, biotin, Choline Chloride；
Fat is made up of the fish oil powder of the vegetable oil of 2.35 parts by weight, the medium chain triglyceride of 0.2 parts by weight and 2.35 parts by weight, protein is by lactalbumin, casein and sea cucumber peptide, carbohydrate is one or both of maltodextrin, sucrose, and dietary fiber is FOS, soybean fiber, Arabic gum, inulin, the one or more of microcrystalline cellulose.
The nutrient profile content of the present invention of table 1
Experiment
1
Three kinds of nutrients by the embodiment of the present invention one to the gained of embodiment three, carry out stability test.
First, accelerated stability of three kinds of nutrients at 9 months is determined（30℃/RH65%）With the long-time stability of 15 months（25℃/RH 60%）, according to《Special medicine purposes formula food general rule》Method specified in GB29922-2013 determines its constituent at 0 day, 9 months and 15 months, records its leading indicator fat, protein, vitamin A, vitamin C, vitamin E, vitamin B1, vitamin B2, vitamin B6, total solid, sodium, potassium, zinc；Smell/taste, pH value, and experiment gained testing result is included in table 2.
As can be seen from Table 2, the every testing result of nutrients of the invention in 9 months accelerated stabilities and the report of stability test in 15 months, is not only conformed with《Special medicine purposes formula food general rule》GB29922-2013 requirement, moreover, meeting the requirement of this enterprise final product quality standard.The nutrients of the present invention is during storage, the changes of contents very little of each nutritional ingredient, there was no significant difference between each nutrient composition content during storage, is held in as defined in standard in content range, i.e., nutritional prods of the invention have good quality stability.
Secondly, the embodiment of the present invention one to three kinds of nutrients of the gained of embodiment three in refrigerator cold-storage after opening bag and is put into tube feed device, has carried out 48 hour stability tests respectively, every testing result also meets enterprise's final product quality standard, steady quality.
Composition analysis result under the product difference resting period of table 2
Experiment
2
The nutrients combination of the present invention is applied to improve patient with operation, chemicotherapy tumor patient immunity, and the embodiment of the present invention one to three kinds of nutrients of the gained of embodiment three is clinically carried out into experiment application.
First, the patient 120 of esophagus or gastrointestinal surgery is chosen, is divided into control group and experimental group, every group 60；Control group eats existing Elental（Commercially available just first board complex peptides special diet nutrient solution）, the nutrients of the edible present invention of experimental group；According to patient's normal nutrition intake, Energy intaking scope is daily 1860-2040kal, and four times a day, each 200mL carries out clinical observation, and experimental result is as shown in table 3.
As can be seen from Table 3, compared with existing Elental, nutrients of the invention can be obviously improved intestinal mucosal permeability（Lactulose/mannitol ratio）, immune indexes（Immunoglobulin, t lymphocyte subset group）；Therefore, the esophagus of nutrients or the patient of gastrointestinal surgery of the present invention is eaten, is improved supplemented with nutriment required in body, immunity in time, shortens the hospital stays, greatly reduce hospitalization cost.
The change of clinical indices after the nutrients of the edible present invention of the patient with operation of table 3
Secondly, postoperative gastric cancer patients undergoing chemotherapy 120 is chosen, is divided into control group and experimental group, every group 60；Control group is eaten, and experimental group eats the nutrients of the present invention；According to patient's normal nutrition intake, Energy intaking scope is daily 1860-2040kal, four times a day, each 200mL, carries out clinical observation；All patients before the treatment, treatment after（Postoperative 7 days）Venous blood samples carry out content detection respectively；And result is handled with biometrical method, experimental result is as shown in table 4.
As can be seen from Table 4, after treatment, the immunoglobulin of experimental group patient（IgM、IgG、IgA）Ascensional range is significantly better than control group, t lymphocyte subset group（CD3、CD4、CD8）It is substantially better than control group；Experimental group patient length of stay, defecation time and evacuation time is significantly shorter than control group first, difference is statistically significant（P<0.05）.This shows that the nutrients of the present invention can significantly improve the immunologic function of postoperative gastric cancer patients undergoing chemotherapy, shortens the hospital stays of patient.
The change of clinical indices after the nutrients of the edible present invention of the patients undergoing chemotherapy of table 4
Beneficial effects of the present invention：Present invention encompasses multiple nutritional components; rich in glutamine, arginine, nucleotides, omega-fatty acid etc.; matched by science, improve the nutrition condition of patient, enhance corrective surgery and the tolerance of postoperative, radiotherapy and chemotherapy; improve the immunity of organisms of patient; acute inflammatory response is controlled, protects function of intestinal mucosa barrier in patient, reduces complication; hospital day is shortened, reduces medical expense；Its is in good taste, no fishlike smell, convenient to take, absorbs fast, steady quality；Its preparation process avoids oxidizable composition in product and oxidation reaction occurs, effectively prevent constituent part and decomposes or destroy because heated excessive or uneven, has fully ensured that the performance of product.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, and within the spirit and principles of the invention, any modification, equivalent substitution and improvements made etc., should be included in the scope of the protection.
Claims (10)
1. a kind of improve operation, the nutrients of chemicotherapy tumor patient immunity, it is characterised in that：Nutrients described in per 100mL includes the composition of following parts by weight：
Protein 4.5-9.8g, fatty 2.2-4.8g, carbohydrate 9.8-24.5g, dietary fiber 0-1.80g, vitamin 0.035-0.075g, mineral trace element 0.36-0.72g, nucleotides 0.10-0.22g, arginine 0.02-2.0g, taurine 0-0.02g, appropriate amount of water.
2. according to claim 1 improve operation, the nutrients of chemicotherapy tumor patient immunity, it is characterised in that：
The mineral trace element includes the element of following parts by weight：Calcium 64-144mg, phosphorus 64-120mg, potassium 128-228mg, sodium 76.8-180mg, magnesium 21.6-38.4mg, iron 0.96-2.16mg, zinc 1.2-2.6mg, iodine 8-25 μ g, selenium 5.4-12.0 μ g, copper 0.14-0.30mg, manganese 0.16-0.35mg；
The raw material of the calcium is calcium monohydrogen phosphate, one or both of calcium carbonate, the raw material of the phosphorus is calcium monohydrogen phosphate, potassium dihydrogen phosphate, one or more in sodium dihydrogen phosphate, the raw material of the potassium is potassium chloride, potassium dihydrogen phosphate, one or more in potassium citrate, the raw material of the sodium is sodium citrate, one or more in sodium dihydrogen phosphate, the raw material of the magnesium is magnesium carbonate, one or both of magnesium chloride, the raw material of the iron is ferric pyrophosphate, one or both of ferrous sulfate, the raw material of the zinc is zinc sulfate, the raw material of the iodine is sodium iodide, KI, one or more in Potassiumiodate, the raw material of the selenium is sodium selenite, the raw material of the copper is copper sulphate, the raw material of the manganese is manganese sulfate, one or both of manganese chloride.
3. according to claim 1 improve operation, the nutrients of chemicotherapy tumor patient immunity, it is characterised in that：
The vitamin includes the composition of following parts by weight：Vitamin A 160-289 μ gRE, vitamin D 1.0-2.0 μ g, vitamin E
4.5-7.5mg α-TE, vitamin B1 0.14-0.24mg, vitamin B2 0.14-0.3mg, vitamin B6 0.12-0.25mg, vitamin B12 0.64-1.0 μ g, vitamin C 6.4-10.0mg, nicotinic acid 1.6-2.7mg, folic acid 22-48 μ g, pantothenic acid 0.55-1.5mg, biotin 8-24 μ g, choline 21-48mg.
4. according to claim 1 improve operation, the nutrients of chemicotherapy tumor patient immunity, it is characterised in that：
The fat is made up of the fish oil powder of the vegetable oil of 1.75-2.35 parts by weight, the medium chain triglyceride of 0.1-0.2 parts by weight and 1.75-2.35 parts by weight, the fish oil powder is the deep-sea fish oil-bound distemper of microencapsulation, the deep-sea fish oil-bound distemper is the one or more in mackerel fish oil powder, catfish fish oil powder, sardine fish oil powder, tuna oil powder, and the vegetable oil is the one or more in high oleic sunflower oil, olive oil, corn oil, sunflower oil.
5. according to claim 1 improve operation, the nutrients of chemicotherapy tumor patient immunity, it is characterised in that：
The protein is the one or more in animal protein, vegetable protein, and the animal protein is one or both of lactalbumin, casein, and the vegetable protein is one or both of soybean protein, wheat gluten.
6. according to claim 5 improve operation, the nutrients of chemicotherapy tumor patient immunity, it is characterised in that：
The protein is made up of lactalbumin, casein and sea cucumber peptide, and the addition of lactalbumin at least accounts for the 50% of total protein in the protein, and the addition of sea cucumber peptide is 1-20g/L, and the mean molecule quantity of the sea cucumber peptide is no more than 5000Da.
7. according to claim 1 improve operation, the nutrients of chemicotherapy tumor patient immunity, it is characterised in that：
The carbohydrate is one or both of maltodextrin, sucrose, and the dietary fiber is FOS, soybean fiber, Arabic gum, inulin, the one or more of microcrystalline cellulose.
8. the raising operation according to any one in claim 1-7, the nutrients of chemicotherapy tumor patient immunity, it is characterised in that：
The formulation of the nutrients is liquid dosage form, and the nutrients also includes emulsifying agent 0.10-0.30g, stabilizer 0.015-0.040g, sweetener 0-0.15g and essence 0-0.50g.
9. a kind of raising according to claim 8 is performed the operation, the preparation method of the nutrients of chemicotherapy tumor patient immunity, it is characterised in that：Comprise the following steps：
1）Dietary fiber is taken, stabilizer is added, is dissolved in more than 70 DEG C of water-bath, forms solution, it is standby；
2）In preparing tank, the part water for the 60-80% for accounting for water inventory is added, in the presence of strong agitation, carbohydrate, protein, the raw material of mineral trace element, nucleotides, arginine and taurine is added, disperses, obtain aqueous phase；
3）By step 1）Resulting solution is added to step 2）In gained aqueous phase, under the protective effect of inert gas, the water-soluble material and sweetener that add in vitamin, aqueous mixture is formed；
4）Fat is taken, under the protective effect of inert gas, the fat-soluble raw material in emulsifying agent and vitamin is added, shears 3-7min, form oil mixture；
5）By step 4）Gained oil mixture and step 3）Gained aqueous mixture mixes, and under the protective effect of inert gas, shearing, colostrum is made；
6）By step 5）Gained colostrum, under the protective effect of inert gas, remaining water is added, regulation pH value is 6.5-7.5, is stirred, and is well mixed, and removes bubble, obtains mixed liquor；
7）In step 6）Essence is added in gained mixed liquor, then, progress is high-pressure homogeneous, and is cooled to 20-30 DEG C, canned, obtains head product；
8）By step 7）Gained head product, sterilized at 115-121 DEG C, F0 values are 10-16, produce product.
10. raising according to claim 9 is performed the operation, the preparation method of the nutrients of chemicotherapy tumor patient immunity, it is characterised in that：
Fat-soluble raw material in the vitamin includes Retinol Palmitate, vitamin D, alpha-tocopherol acetate；
Water-soluble material in the cellulose includes thiamine hydrochloride, Riboflavine sodium phosphate, hydrochloric acid pyrrole and trembled zinc, vitamin B12, vitamin C, nicotinic acid, folic acid, calcium pantothenate, biotin, Choline Chloride；
The step 7）In, the product after cooling is filled in Brown Glass Brown glass bottles and jars only or lucifuge and the high bag of barrier；The step 8）In, sterilizing is carried out in rotating type sterilization cabinet.
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