CN108936597A - A kind of carcinoma of the rectum nutraceutical and preparation method thereof - Google Patents
A kind of carcinoma of the rectum nutraceutical and preparation method thereof Download PDFInfo
- Publication number
- CN108936597A CN108936597A CN201810433939.5A CN201810433939A CN108936597A CN 108936597 A CN108936597 A CN 108936597A CN 201810433939 A CN201810433939 A CN 201810433939A CN 108936597 A CN108936597 A CN 108936597A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- raw material
- calcium
- rectum
- nutraceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 201000001275 rectum cancer Diseases 0.000 title claims abstract description 41
- 239000002417 nutraceutical Substances 0.000 title claims abstract description 29
- 235000021436 nutraceutical agent Nutrition 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 235000016709 nutrition Nutrition 0.000 claims abstract description 30
- 230000035764 nutrition Effects 0.000 claims abstract description 19
- 235000019197 fats Nutrition 0.000 claims abstract description 10
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 9
- 235000014633 carbohydrates Nutrition 0.000 claims abstract description 9
- 239000009429 Ginkgo biloba extract Substances 0.000 claims abstract description 8
- 229940068052 ginkgo biloba extract Drugs 0.000 claims abstract description 8
- 235000020686 ginkgo biloba extract Nutrition 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims description 58
- 101100223916 Drosophila melanogaster pea gene Proteins 0.000 claims description 23
- 101100202725 Escherichia coli (strain K12) secA gene Proteins 0.000 claims description 23
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 22
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 22
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 20
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 17
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 17
- 239000011575 calcium Substances 0.000 claims description 17
- 229960005069 calcium Drugs 0.000 claims description 17
- 229910052791 calcium Inorganic materials 0.000 claims description 17
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 16
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 16
- 108010084695 Pea Proteins Proteins 0.000 claims description 16
- 235000019702 pea protein Nutrition 0.000 claims description 16
- 239000003921 oil Substances 0.000 claims description 15
- 235000019198 oils Nutrition 0.000 claims description 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 14
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 13
- 238000006243 chemical reaction Methods 0.000 claims description 13
- 229960003512 nicotinic acid Drugs 0.000 claims description 13
- 239000011664 nicotinic acid Substances 0.000 claims description 13
- 235000001968 nicotinic acid Nutrition 0.000 claims description 13
- 239000004475 Arginine Substances 0.000 claims description 12
- 102000004407 Lactalbumin Human genes 0.000 claims description 12
- 108090000942 Lactalbumin Proteins 0.000 claims description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 12
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 12
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 claims description 12
- 230000001954 sterilising effect Effects 0.000 claims description 12
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 12
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 11
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 10
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 10
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 10
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 10
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 10
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 10
- 229910052804 chromium Inorganic materials 0.000 claims description 10
- 239000011651 chromium Substances 0.000 claims description 10
- 238000001976 enzyme digestion Methods 0.000 claims description 10
- 229960000304 folic acid Drugs 0.000 claims description 10
- 235000019152 folic acid Nutrition 0.000 claims description 10
- 239000011724 folic acid Substances 0.000 claims description 10
- 239000011772 phylloquinone Substances 0.000 claims description 10
- 239000011669 selenium Substances 0.000 claims description 10
- 239000011734 sodium Substances 0.000 claims description 10
- 229910052708 sodium Inorganic materials 0.000 claims description 10
- 235000015424 sodium Nutrition 0.000 claims description 10
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 10
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 9
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 9
- 235000013325 dietary fiber Nutrition 0.000 claims description 9
- 239000004615 ingredient Substances 0.000 claims description 9
- 229910052742 iron Inorganic materials 0.000 claims description 9
- 239000011777 magnesium Substances 0.000 claims description 9
- 229910052749 magnesium Inorganic materials 0.000 claims description 9
- 235000001055 magnesium Nutrition 0.000 claims description 9
- MBWXNTAXLNYFJB-LKUDQCMESA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCCC(C)CCCC(C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-LKUDQCMESA-N 0.000 claims description 9
- 239000011701 zinc Substances 0.000 claims description 9
- 229910052725 zinc Inorganic materials 0.000 claims description 9
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 8
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 8
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 8
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 8
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 8
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 8
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 8
- 229930003316 Vitamin D Natural products 0.000 claims description 8
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 8
- 229930003427 Vitamin E Natural products 0.000 claims description 8
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 8
- 239000010949 copper Substances 0.000 claims description 8
- 229910052802 copper Inorganic materials 0.000 claims description 8
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 8
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 8
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 8
- 235000019161 pantothenic acid Nutrition 0.000 claims description 8
- 239000011713 pantothenic acid Substances 0.000 claims description 8
- 229940055726 pantothenic acid Drugs 0.000 claims description 8
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 8
- 229960003975 potassium Drugs 0.000 claims description 8
- 239000011591 potassium Substances 0.000 claims description 8
- 229910052700 potassium Inorganic materials 0.000 claims description 8
- 235000007686 potassium Nutrition 0.000 claims description 8
- 235000019192 riboflavin Nutrition 0.000 claims description 8
- 239000002151 riboflavin Substances 0.000 claims description 8
- 229960002477 riboflavin Drugs 0.000 claims description 8
- 229910052711 selenium Inorganic materials 0.000 claims description 8
- 229940091258 selenium supplement Drugs 0.000 claims description 8
- 235000002639 sodium chloride Nutrition 0.000 claims description 8
- 235000019155 vitamin A Nutrition 0.000 claims description 8
- 239000011719 vitamin A Substances 0.000 claims description 8
- 239000011691 vitamin B1 Substances 0.000 claims description 8
- 239000011715 vitamin B12 Substances 0.000 claims description 8
- 239000011716 vitamin B2 Substances 0.000 claims description 8
- 235000019166 vitamin D Nutrition 0.000 claims description 8
- 239000011710 vitamin D Substances 0.000 claims description 8
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 8
- 229940046009 vitamin E Drugs 0.000 claims description 8
- 235000019165 vitamin E Nutrition 0.000 claims description 8
- 239000011709 vitamin E Substances 0.000 claims description 8
- 229940045997 vitamin a Drugs 0.000 claims description 8
- 229940046008 vitamin d Drugs 0.000 claims description 8
- 229930091371 Fructose Natural products 0.000 claims description 7
- 239000005715 Fructose Substances 0.000 claims description 7
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 7
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 7
- 229920000294 Resistant starch Polymers 0.000 claims description 7
- 229920002472 Starch Polymers 0.000 claims description 7
- 235000021323 fish oil Nutrition 0.000 claims description 7
- 229940099596 manganese sulfate Drugs 0.000 claims description 7
- 239000011702 manganese sulphate Substances 0.000 claims description 7
- 235000007079 manganese sulphate Nutrition 0.000 claims description 7
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 229910052698 phosphorus Inorganic materials 0.000 claims description 7
- 239000011574 phosphorus Substances 0.000 claims description 7
- 235000021254 resistant starch Nutrition 0.000 claims description 7
- 235000019698 starch Nutrition 0.000 claims description 7
- 239000008107 starch Substances 0.000 claims description 7
- 239000011726 vitamin B6 Substances 0.000 claims description 7
- 101000693530 Staphylococcus aureus Staphylokinase Proteins 0.000 claims description 6
- RZFHLOLGZPDCHJ-DLQZEEBKSA-N alpha-Tocotrienol Natural products Oc1c(C)c(C)c2O[C@@](CC/C=C(/CC/C=C(\CC/C=C(\C)/C)/C)\C)(C)CCc2c1C RZFHLOLGZPDCHJ-DLQZEEBKSA-N 0.000 claims description 6
- 235000020958 biotin Nutrition 0.000 claims description 6
- 239000011616 biotin Substances 0.000 claims description 6
- 229960002685 biotin Drugs 0.000 claims description 6
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims description 6
- 239000001354 calcium citrate Substances 0.000 claims description 6
- 229960004256 calcium citrate Drugs 0.000 claims description 6
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 claims description 6
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 6
- 235000000639 cyanocobalamin Nutrition 0.000 claims description 6
- 239000011666 cyanocobalamin Substances 0.000 claims description 6
- 229960002104 cyanocobalamin Drugs 0.000 claims description 6
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims description 6
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 claims description 6
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 6
- 239000001508 potassium citrate Substances 0.000 claims description 6
- 229960002635 potassium citrate Drugs 0.000 claims description 6
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 6
- 235000011082 potassium citrates Nutrition 0.000 claims description 6
- 239000001230 potassium iodate Substances 0.000 claims description 6
- 235000006666 potassium iodate Nutrition 0.000 claims description 6
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical group [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 claims description 6
- 229940093930 potassium iodate Drugs 0.000 claims description 6
- 239000011780 sodium chloride Substances 0.000 claims description 6
- 239000011781 sodium selenite Substances 0.000 claims description 6
- 235000015921 sodium selenite Nutrition 0.000 claims description 6
- 229960001471 sodium selenite Drugs 0.000 claims description 6
- 239000011747 thiamine hydrochloride Substances 0.000 claims description 6
- 235000019190 thiamine hydrochloride Nutrition 0.000 claims description 6
- 229960000344 thiamine hydrochloride Drugs 0.000 claims description 6
- 235000013337 tricalcium citrate Nutrition 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- RZFHLOLGZPDCHJ-XZXLULOTSA-N α-tocotrienol group Chemical group C[C@@]1(OC2=C(C(=C(C(=C2CC1)C)O)C)C)CC\C=C(\CC\C=C(\CCC=C(C)C)/C)/C RZFHLOLGZPDCHJ-XZXLULOTSA-N 0.000 claims description 6
- 239000011665 D-biotin Substances 0.000 claims description 5
- 235000000638 D-biotin Nutrition 0.000 claims description 5
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 5
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 5
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 claims description 5
- 235000006484 Paeonia officinalis Nutrition 0.000 claims description 5
- 235000019483 Peanut oil Nutrition 0.000 claims description 5
- 241000201912 Suaeda Species 0.000 claims description 5
- 229930003268 Vitamin C Natural products 0.000 claims description 5
- 240000008042 Zea mays Species 0.000 claims description 5
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 5
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 5
- 235000005822 corn Nutrition 0.000 claims description 5
- 235000005911 diet Nutrition 0.000 claims description 5
- 230000037213 diet Effects 0.000 claims description 5
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 claims description 5
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 5
- 239000011773 ferrous fumarate Substances 0.000 claims description 5
- 235000002332 ferrous fumarate Nutrition 0.000 claims description 5
- 229960000225 ferrous fumarate Drugs 0.000 claims description 5
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 5
- 239000000395 magnesium oxide Substances 0.000 claims description 5
- 239000000312 peanut oil Substances 0.000 claims description 5
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 5
- 229960000342 retinol acetate Drugs 0.000 claims description 5
- 235000019173 retinyl acetate Nutrition 0.000 claims description 5
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 claims description 5
- 239000011770 retinyl acetate Substances 0.000 claims description 5
- 235000012424 soybean oil Nutrition 0.000 claims description 5
- 239000003549 soybean oil Substances 0.000 claims description 5
- 235000019154 vitamin C Nutrition 0.000 claims description 5
- 239000011718 vitamin C Substances 0.000 claims description 5
- 239000011653 vitamin D2 Substances 0.000 claims description 5
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims description 5
- 239000011787 zinc oxide Substances 0.000 claims description 5
- 235000014692 zinc oxide Nutrition 0.000 claims description 5
- DBTMGCOVALSLOR-DEVYUCJPSA-N (2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](CO)O[C@H](O)[C@@H]2O)O)O[C@H](CO)[C@H]1O DBTMGCOVALSLOR-DEVYUCJPSA-N 0.000 claims description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical group [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- 229910021555 Chromium Chloride Inorganic materials 0.000 claims description 4
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical group CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 4
- 239000005717 Laminarin Substances 0.000 claims description 4
- 229920001543 Laminarin Polymers 0.000 claims description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 4
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims description 4
- 239000001506 calcium phosphate Substances 0.000 claims description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 4
- QSWDMMVNRMROPK-UHFFFAOYSA-K chromium(3+) trichloride Chemical group [Cl-].[Cl-].[Cl-].[Cr+3] QSWDMMVNRMROPK-UHFFFAOYSA-K 0.000 claims description 4
- 229940042585 tocopherol acetate Drugs 0.000 claims description 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 4
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 4
- 239000011746 zinc citrate Substances 0.000 claims description 4
- 235000006076 zinc citrate Nutrition 0.000 claims description 4
- 229940068475 zinc citrate Drugs 0.000 claims description 4
- 229960001296 zinc oxide Drugs 0.000 claims description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 3
- 239000005913 Maltodextrin Substances 0.000 claims description 3
- 229920002774 Maltodextrin Polymers 0.000 claims description 3
- 235000004347 Perilla Nutrition 0.000 claims description 3
- 244000124853 Perilla frutescens Species 0.000 claims description 3
- 235000019484 Rapeseed oil Nutrition 0.000 claims description 3
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims description 3
- 150000003271 galactooligosaccharides Chemical class 0.000 claims description 3
- 239000011630 iodine Substances 0.000 claims description 3
- 229910052740 iodine Inorganic materials 0.000 claims description 3
- 150000002632 lipids Chemical class 0.000 claims description 3
- 229940035034 maltodextrin Drugs 0.000 claims description 3
- 235000005713 safflower oil Nutrition 0.000 claims description 3
- 239000003813 safflower oil Substances 0.000 claims description 3
- RZFHLOLGZPDCHJ-KTWAZNHYSA-N 2,5,7,8-tetramethyl-2-[(3e,7e)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol Chemical compound OC1=C(C)C(C)=C2OC(CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1C RZFHLOLGZPDCHJ-KTWAZNHYSA-N 0.000 claims description 2
- 241000208140 Acer Species 0.000 claims description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- 239000001736 Calcium glycerylphosphate Substances 0.000 claims description 2
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims description 2
- 239000011626 DL-alpha-tocopherylacetate Chemical group 0.000 claims description 2
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 claims description 2
- DKKCQDROTDCQOR-UHFFFAOYSA-L Ferrous lactate Chemical compound [Fe+2].CC(O)C([O-])=O.CC(O)C([O-])=O DKKCQDROTDCQOR-UHFFFAOYSA-L 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 2
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 2
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 2
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims description 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims description 2
- 235000013734 beta-carotene Nutrition 0.000 claims description 2
- 239000011648 beta-carotene Substances 0.000 claims description 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 2
- 229960002747 betacarotene Drugs 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims description 2
- MDXRFOWKIZPNTA-UHFFFAOYSA-L butanedioate;iron(2+) Chemical compound [Fe+2].[O-]C(=O)CCC([O-])=O MDXRFOWKIZPNTA-UHFFFAOYSA-L 0.000 claims description 2
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims description 2
- 239000001639 calcium acetate Substances 0.000 claims description 2
- 235000011092 calcium acetate Nutrition 0.000 claims description 2
- 229960005147 calcium acetate Drugs 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 229960003563 calcium carbonate Drugs 0.000 claims description 2
- 235000010216 calcium carbonate Nutrition 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
- 229960002713 calcium chloride Drugs 0.000 claims description 2
- 235000011148 calcium chloride Nutrition 0.000 claims description 2
- 239000004227 calcium gluconate Substances 0.000 claims description 2
- 235000013927 calcium gluconate Nutrition 0.000 claims description 2
- 229960004494 calcium gluconate Drugs 0.000 claims description 2
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 claims description 2
- 229940095618 calcium glycerophosphate Drugs 0.000 claims description 2
- 235000019299 calcium glycerylphosphate Nutrition 0.000 claims description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 2
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 2
- 239000001527 calcium lactate Substances 0.000 claims description 2
- 235000011086 calcium lactate Nutrition 0.000 claims description 2
- 229960002401 calcium lactate Drugs 0.000 claims description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 2
- 235000011010 calcium phosphates Nutrition 0.000 claims description 2
- MKJXYGKVIBWPFZ-CEOVSRFSSA-L calcium;(2s)-2-hydroxypropanoate Chemical compound [Ca+2].C[C@H](O)C([O-])=O.C[C@H](O)C([O-])=O MKJXYGKVIBWPFZ-CEOVSRFSSA-L 0.000 claims description 2
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 229940108925 copper gluconate Drugs 0.000 claims description 2
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 2
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 2
- 235000013924 ferrous gluconate Nutrition 0.000 claims description 2
- 239000004222 ferrous gluconate Substances 0.000 claims description 2
- 229960001645 ferrous gluconate Drugs 0.000 claims description 2
- 235000013925 ferrous lactate Nutrition 0.000 claims description 2
- 239000004225 ferrous lactate Substances 0.000 claims description 2
- 229940037907 ferrous lactate Drugs 0.000 claims description 2
- 229960001604 ferrous succinate Drugs 0.000 claims description 2
- 229960001781 ferrous sulfate Drugs 0.000 claims description 2
- 239000011790 ferrous sulphate Substances 0.000 claims description 2
- 235000003891 ferrous sulphate Nutrition 0.000 claims description 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 2
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 2
- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical compound [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 claims description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 2
- 239000001095 magnesium carbonate Substances 0.000 claims description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 2
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 2
- 229910052748 manganese Inorganic materials 0.000 claims description 2
- 239000011572 manganese Substances 0.000 claims description 2
- 239000011683 manganese gluconate Substances 0.000 claims description 2
- 235000014012 manganese gluconate Nutrition 0.000 claims description 2
- 229940072543 manganese gluconate Drugs 0.000 claims description 2
- OXHQNTSSPHKCPB-IYEMJOQQSA-L manganese(2+);(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Mn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OXHQNTSSPHKCPB-IYEMJOQQSA-L 0.000 claims description 2
- 229960003966 nicotinamide Drugs 0.000 claims description 2
- 235000005152 nicotinamide Nutrition 0.000 claims description 2
- 239000011570 nicotinamide Substances 0.000 claims description 2
- 235000011007 phosphoric acid Nutrition 0.000 claims description 2
- 239000001103 potassium chloride Substances 0.000 claims description 2
- 235000011164 potassium chloride Nutrition 0.000 claims description 2
- 229940108325 retinyl palmitate Drugs 0.000 claims description 2
- 235000019172 retinyl palmitate Nutrition 0.000 claims description 2
- 239000011769 retinyl palmitate Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000001488 sodium phosphate Substances 0.000 claims description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- UIERGBJEBXXIGO-UHFFFAOYSA-N thiamine mononitrate Chemical compound [O-][N+]([O-])=O.CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N UIERGBJEBXXIGO-UHFFFAOYSA-N 0.000 claims description 2
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 2
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 2
- 239000011647 vitamin D3 Substances 0.000 claims description 2
- 239000011670 zinc gluconate Substances 0.000 claims description 2
- 235000011478 zinc gluconate Nutrition 0.000 claims description 2
- 229960000306 zinc gluconate Drugs 0.000 claims description 2
- 239000011576 zinc lactate Substances 0.000 claims description 2
- 235000000193 zinc lactate Nutrition 0.000 claims description 2
- 229940050168 zinc lactate Drugs 0.000 claims description 2
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 2
- 229960001763 zinc sulfate Drugs 0.000 claims description 2
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 244000170916 Paeonia officinalis Species 0.000 claims 1
- PBUBJNYXWIDFMU-UHFFFAOYSA-L calcium;butanedioate Chemical compound [Ca+2].[O-]C(=O)CCC([O-])=O PBUBJNYXWIDFMU-UHFFFAOYSA-L 0.000 claims 1
- 230000007071 enzymatic hydrolysis Effects 0.000 claims 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 abstract description 19
- 235000013305 food Nutrition 0.000 abstract description 15
- 208000015634 Rectal Neoplasms Diseases 0.000 abstract description 7
- 230000033228 biological regulation Effects 0.000 abstract description 7
- 206010038038 rectal cancer Diseases 0.000 abstract description 7
- 206010067484 Adverse reaction Diseases 0.000 abstract description 5
- 230000006838 adverse reaction Effects 0.000 abstract description 5
- 230000004888 barrier function Effects 0.000 abstract description 5
- 208000015181 infectious disease Diseases 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 4
- 230000036039 immunity Effects 0.000 abstract description 4
- 210000004347 intestinal mucosa Anatomy 0.000 abstract description 4
- 230000035479 physiological effects, processes and functions Effects 0.000 abstract description 4
- 230000022558 protein metabolic process Effects 0.000 abstract description 4
- 238000001243 protein synthesis Methods 0.000 abstract description 4
- 239000003053 toxin Substances 0.000 abstract description 4
- 231100000765 toxin Toxicity 0.000 abstract description 4
- 230000014616 translation Effects 0.000 abstract description 4
- 230000017105 transposition Effects 0.000 abstract description 4
- 230000006872 improvement Effects 0.000 abstract description 3
- 230000002503 metabolic effect Effects 0.000 abstract description 3
- 230000000968 intestinal effect Effects 0.000 abstract description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 235000010755 mineral Nutrition 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 10
- 230000006870 function Effects 0.000 description 9
- 201000011510 cancer Diseases 0.000 description 6
- 208000002720 Malnutrition Diseases 0.000 description 4
- 241000736199 Paeonia Species 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000001071 malnutrition Effects 0.000 description 4
- 235000000824 malnutrition Nutrition 0.000 description 4
- 208000015380 nutritional deficiency disease Diseases 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 241000219226 Acer truncatum Species 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000036737 immune function Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- LFDGRWDETVOGDT-UHFFFAOYSA-N 1h-pyrrole;hydrochloride Chemical compound Cl.C=1C=CNC=1 LFDGRWDETVOGDT-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 244000194101 Ginkgo biloba Species 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 206010044565 Tremor Diseases 0.000 description 2
- 235000021120 animal protein Nutrition 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000005660 chlorination reaction Methods 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000036542 oxidative stress Effects 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 229960002668 sodium chloride Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 150000005846 sugar alcohols Chemical class 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 2
- VRKKUDZYIGLTIC-UHFFFAOYSA-N 2-phenylchromen-4-one silver Chemical compound [Ag].O1C(=CC(=O)C2=CC=CC=C12)C1=CC=CC=C1 VRKKUDZYIGLTIC-UHFFFAOYSA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 208000021959 Abnormal metabolism Diseases 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- IELOKBJPULMYRW-NJQVLOCASA-N D-alpha-Tocopheryl Acid Succinate Chemical compound OC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C IELOKBJPULMYRW-NJQVLOCASA-N 0.000 description 1
- 206010012374 Depressed mood Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 108010082495 Dietary Plant Proteins Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- 206010018364 Glomerulonephritis Diseases 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000008192 Lactoglobulins Human genes 0.000 description 1
- 108010060630 Lactoglobulins Proteins 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 101710094902 Legumin Proteins 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 229920000377 Sinistrin Polymers 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- -1 Superoxide anion free radical Chemical class 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000031016 anaphase Effects 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- DGUIQJBLMCNAIE-UHFFFAOYSA-N butanedioic acid;calcium Chemical compound [Ca].OC(=O)CCC(O)=O DGUIQJBLMCNAIE-UHFFFAOYSA-N 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 230000003185 calcium uptake Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- NEKNNCABDXGBEN-UHFFFAOYSA-L disodium;4-(4-chloro-2-methylphenoxy)butanoate;4-(2,4-dichlorophenoxy)butanoate Chemical compound [Na+].[Na+].CC1=CC(Cl)=CC=C1OCCCC([O-])=O.[O-]C(=O)CCCOC1=CC=C(Cl)C=C1Cl NEKNNCABDXGBEN-UHFFFAOYSA-L 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 208000033065 inborn errors of immunity Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229960003284 iron Drugs 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000004213 low-fat Nutrition 0.000 description 1
- 229940091250 magnesium supplement Drugs 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000006371 metabolic abnormality Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000003715 nutritional status Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 235000016236 parenteral nutrition Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 235000021003 saturated fats Nutrition 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000000192 social effect Effects 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 235000020795 whole food diet Nutrition 0.000 description 1
- 235000021241 α-lactalbumin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention belongs to technical field of nutritional food, and in particular to a kind of carcinoma of the rectum nutraceutical and preparation method thereof.Contain albumen, fat, carbohydrate, vitamin, minerals, GINKGO BILOBA EXTRACT, phytosterol nutrient in the carcinoma of the rectum nutraceutical.Nutraceutical of the invention for body other than it can provide sufficient, comprehensive nutrition, more importantly enhance the barrier function of intestinal mucosa, more meet metabolic physiology state, be conducive to body protein synthesis and Metabolism regulation, function of intestinal canal and form is promoted to restore, prevent bacterium and toxin transposition, hence it is evident that the generation for reducing enterogenic infection is the effective means for improving patients undergoing chemotherapy nutrition condition.Certain improvement result can be played to the nutrition condition of Advanced Rectal Cancer patients undergoing chemotherapy, reduced patient's adverse reaction, can be effectively improved the immunity of patient.
Description
Technical field
The invention belongs to technical field of nutritional food, and in particular to a kind of carcinoma of the rectum nutraceutical and preparation method thereof.
Technical background
It is shown according to the data that World Health Organization's International Cancer Research Center (IARC) is announced, the global carcinoma of the rectum is new within 2012
Morbidity example about 1,360,000, accounts for the 9.7% of whole new cancer cases.Cancer Hospital of Chinese Academy of Medical Sciences/National Cancer Center
Statistical data show, China's colorectal cancer incidence rate in 2015, the death rate occupied in whole malignant tumours before 5.
The energy consumption of tumour itself, host will lead to the reaction of tumour and the intervention of various antineoplastons etc.
There are abnormal metabolism states in body.40%~80% malignant tumor patient is with different degrees of malnutrition, and about 20%
Malignant tumor patient directly dies of malnutrition, and malnutrition seriously affects the life span and quality of life of patient.Nutrition is not
It is good be usually by take the photograph people measure reduce, physiological activity decline, organism metabolic disorder cause, will seriously affect clinical prognosis.Cause to swell
The decline of tumor quality of life of patients, prognosis mala and the risk and death that increase the adverse reaction of tumour patient treatment, increase infection
Rate.Therefore, the nutrition condition for improving cancer patient is particularly significant, and patient can be helped to keep weight, reduce chemotherapy and radiotherapy not
It is good to react, improve the quality of living, extending tumour patient life cycle.
Chemotherapy is the important means of Advanced Rectal Cancer Patient Global treatment, but digestive tract reaction caused by chemotherapeutics
The adverse reactions such as disease, hypoimmunity, hemopoietic system be suppressed further can be such that Nutritional Status of Patients deteriorates；It is malnutritive to lead again
Tumor patient is caused to decline the tolerance of the antineoplastons such as further chemotherapy.Chemotherapy causes underfed the reason is that multi-party
Face, immediate cause is the symptoms such as nausea,vomiting,diarrhea caused by chemotherapy, caused gastrointestinal tract mucosa injury, appetite stimulator, is influenced
Nutriment takes the photograph people, while related to being absorbed and utilized for nutriment with chemotherapeutics interference human body.During chemotherapy of patients,
Malnutrition not only will affect the physiology and psychological condition of patient itself, but also will affect anaphase effect and patient
Quality of life, or even shorten life cycle.Early detection and to give treatment appropriate for malnutritive situation very necessary.Improve
The nutrition condition of chemotherapy patients not only facilitates the recovery of body, improves immune function, and can also improve the tolerance to chemotherapy
Property, improve therapeutic effect and life quality, extend life cycle.
It is the preferred approach of rectal cancer patient nutritional support, formula of the invention using formula food as the enteral nutrition of form
Food for body other than it can provide sufficient, comprehensive nutrition, it is often more important that enhance the barrier function of intestinal mucosa, more accord with
Metabolic physiology state is closed, body protein synthesis and Metabolism regulation are conducive to, promotes function of intestinal canal and form to restore, prevents bacterium
With toxin transposition, hence it is evident that the generation for reducing enterogenic infection is the effective means for improving patients undergoing chemotherapy nutrition condition.To middle and advanced stage
The nutrition condition of carcinoma of the rectum patients undergoing chemotherapy can play certain improvement result, reduce patient's adverse reaction, can effectively improve trouble
The immunity of person.
For special medicine purposes food, there are corresponding regulation and exploitation to answer in developed countries such as the U.S., European Union, Japan
With；Wholefood is clear in China GB29922-2013 " special medicine purposes formula food general rule " national food safety standard
Regulation full nutrition formula food, which refers to, can be used as the special medicine purposes formula food that single source of nutrition meets patient's nutritional need
Product.It is there is no currently on the market for the special medicine purposes food during carcinoma of the rectum chemotherapy, especially for year age grade
Section, what specific physiological status rectal cancer patient was designed.And such food products market has a high potential, high financial profit, therefore opens
This based food is sent out, there is great economic benefit and social effect.
Summary of the invention
The object of the present invention is to provide a kind of carcinoma of the rectum nutraceutical, can provide for body outside sufficient, comprehensive nutrition,
The barrier function that intestinal mucosa can more importantly be enhanced is conducive to body protein synthesis and Metabolism regulation, promotes enteron aisle
Function and form are restored, and prevent bacterium and toxin transposition, hence it is evident that reduce the generation of enterogenic infection；Present invention simultaneously provides its systems
Preparation Method.
A kind of carcinoma of the rectum full nutrition formula food of the present invention, nutritional ingredient is as follows in every hectogram nutraceutical: egg
White 34g-58g, fat 1.3g-4g, carbohydrate 34g-60g, 159 μ g-889 μ g of vitamin A, 4 μ g-13 μ g of vitamin D,
Vitamin E 4mg-50mg, vitamin K1 17 μ g-185 μ g, vitamin B1 330 μ g-1mg, vitamin B2 332 μ g-1mg, dimension life
Plain B6 332 μ g-1mg, vitamin B12 1 μ g-20 μ g, niacin 0.9mg-9mg, 88 μ g-938 μ g of folic acid, pantothenic acid 2mg-20mg, dimension
Raw element C 3mg-7.2mg, 9 μ g-85 μ g of biotin, sodium 300mg-330mg, potassium 446mg-545mg, 182 μ g-230 μ g of copper, magnesium
73mg-100mg, iron 4mg-9mg, zinc 2mg-8mg, 99 μ g-2.5mg of manganese, calcium 215mg-222mg, 159mg-164mg, 27 μ g- of iodine
50 μ g, it 13 μ g-91 μ g of selenium, 7 μ g-228 μ g of chromium, glutamine 1g-6g, arginine 500mg-1g, GINKGO BILOBA EXTRACT 500mg-4g, plants
Object sterol 300mg-600mg.
Wherein:
The raw material of albumen is selected from pea protein and lactalbumin or pea peptide and lactalbumin；
The raw material of fat is selected from fish oil and soybean oil, rapeseed oil, peanut oil, Corn Seeds oil, safflower oil, perilla herb oil, samara oil, member
Precious maple seed oil, peony seed oil, common seepweed seeds oil etc. one or more；
The raw material of carbohydrate be selected from xylo-oligosaccharide, galactooligosaccharide, fructose, antierythrite, laminarin, maltodextrin,
One of hydroxypropul starch, dietary fiber or resistant starch are a variety of；The preferred polyfructosan of fructose；The preferred pea of dietary fiber
Dietary fiber；The preferred pea resistant starch of resistant starch；
The raw material of vitamin A is selected from one of retinol acetate, retinyl palmitate or beta carotene or a variety of；
The raw material of vitamin D is selected from vitamin D2, vitamin D3One or both of；
The raw material of vitamin E is selected from one of D- alpha-tocotrienol, dl-alpha-tocotrienol, VE succinic acid calcium
Or it is a variety of；The preferred D- α-tocopherol acetate trienol of D- alpha-tocotrienol, D- α-tocopheryl succinate trienol, dl-α-fertility three
Preferred dl-α-tocopherol acetate the trienol of alkene phenol；
Vitamin B1Raw material be selected from one or both of thiamine hydrochloride, Thiamin mononitrate；
Vitamin B2Raw material be selected from one or both of riboflavin or riboflavin 5 '-sodium phosphate；
Vitamin B6Raw material be selected from puridoxine hydrochloride；
Vitamin B12Raw material be selected from cyanocobalamin；
The raw material of niacin is selected from one or both of niacin or niacinamide；
The raw material of pantothenic acid is selected from D-VB5 calcium；
Ascorbic raw material is in L-AA, L-AA sodium, L-AA calcium or ascorbyl palmitate
It is one or more；
The raw material of biotin is selected from D-Biotin；
The raw material of sodium is selected from sodium chloride；
The raw material of potassium is selected from one of dipotassium hydrogen phosphate, potassium dihydrogen phosphate, potassium chloride, potassium citrate or a variety of；
The raw material of copper is selected from one or both of copper sulphate or copper gluconate；
The raw material of magnesium is selected from one of magnesium carbonate, magnesium sulfate, magnesia, magnesium chloride or L- magnesium threonate or a variety of；
The raw material of iron is selected from one of ferrous gluconate, ferrous fumarate, ferrous sulfate, ferrous lactate or ferrous succinate
Or it is a variety of；
The raw material of zinc is selected from zinc sulfate, zinc citrate, zinc citrate (three water), zinc gluconate, zinc oxide or zinc lactate
It is one or more；
The raw material of manganese is selected from one or both of manganese sulfate or manganese gluconate；
The raw material of calcium is selected from calcium carbonate, calcium acetate, calcium chloride, calcium citrate, calcium gluconate, calcium lactate, calcium monohydrogen phosphate, phosphoric acid
One of calcium dihydrogen, tricalcium phosphate (calcium phosphate), calcium sulfate, L-calcium lactate or calcium glycerophosphate are a variety of；
The raw material of phosphorus is selected from potassium dihydrogen phosphate；
The raw material of iodine is selected from Potassiumiodate；
The raw material of selenium is selected from one of sodium selenite, Se-enriched yeast or L- selenium-methyl selenium substituted aminothiopropionic or a variety of；
The raw material of chromium is selected from chromium chloride.
Pea peptide of the present invention the preparation method comprises the following steps: the pea protein of water content 25wt.% is squeezed, after extruding, will squeeze
Object is cooling out, drying, crushes, then carries out enzyme digestion reaction with neutral proteinase.
Wherein: temperature when extruding is 60 DEG C, screw speed 165r/min, and die hole aperture is 12mm.
Enzymolysis temperature is 38 DEG C, and the pH value of enzyme digestion reaction is 7, and pea protein concentration is 8.1 g/ in enzyme digestion reaction
ML, the dosage of neutral proteinase are the 12% of pea protein dosage.
After enzyme digestion reaction, the DPPH clearance rate of pea peptide,.OH clearance rate, O2 .-Clearance rate is respectively 95%, 88%, 45%.
Carcinoma of the rectum nutraceutical of the present invention the preparation method is as follows: in terms of 100 grams of carcinoma of the rectum nutraceutical quality,
By albumen, carbohydrate, vitamin A, vitamin D, vitamin E, vitamin K1, vitamin B1, vitamin B2, vitamin B6、
Vitamin B12, niacin, folic acid, pantothenic acid, vitamin C, biotin, sodium, potassium, copper, magnesium, iron, zinc, manganese, calcium, phosphorus, iodine, selenium, chromium, paddy
Glutamine, arginine, GINKGO BILOBA EXTRACT, phytosterol nutritional ingredient raw material sterilizing after, be divided into 5 parts, form function bag；
After the raw material sterilizing of lipid nutrition ingredient, 5 parts are divided into, energy bag is formed.
Wherein: sterilizing power is 400-500W, sterilization time 100-120s.
The eating method of carcinoma of the rectum nutraceutical of the present invention is as follows:
The age of target group is 18-64 years old, does not include pregnant woman and breast feeding women；
Dosage are as follows: 0.4 bag/(kgd), total amount is no more than 27 bags；
It is edible according to one of following two method:
(1) it is cooled to 40-60 DEG C with the boiled water of 100-400mL, the nutriment in function bag and energy bag is added, stirs, shake
After even, directly drink or taken in through tube feed；
(2) nutriment in function bag is added in the diet without containing salt and is eaten, contained in diet
Fat is consistent with the fat content in energy bag.
The marketing method of product of the present invention is to be distributed directly to consumer, by the places such as hospital, supermarket or pharmacy or
The characteristics of approach is cut down the number of intermediate links, and is reduced expense, is realized low price sale with small profits, the food that consumer can be more economical, more economical
With meeting the edible requirement of long term consumer.
Beneficial effects of the present invention are as follows:
The effect of carcinoma of the rectum nutraceutical of the present invention depends on each self-applying and synergistic effect to each other of nutritional ingredient.
In the present invention, pea protein or pea peptide have the effect of significantly efficiently removing various free radicals, and DPPH is clear
Except rate,.OH clearance rate, O2 .-Clearance rate is respectively 95%, 88%, 45%, also has anti-inflammatory, immunological regulation, inhibits feritin and ACE
The effect of enzymatic activity, especially have anti-curing cancers caused by complication effect related with oxidative stress, the pea protein or
Pea peptide have selective clearing cause the carcinoma of the rectum ROS substance DPPH and.OH, and the O for rectum cancer cell can be killed2 .-
With lower clearance rate, to ensure that O2 .-High existence rate and high killing cancer cell effect.Meanwhile pea commercial variety there is no
Transformed variety, sensitization is low, no feeding intolerance；The oxygen that pea protein peptide can remove glomerulonephritis with specific aim is free
Base and MDA, to improve patient body state, furthermore compared with other protein or peptide, it is also rich in arginine, reduces volume
The outer arginic amount of supplement.
Lactalbumin is good protein, containing the various actives such as beta lactoglobulin, α-lactalbumin, immunoglobulin at
Point；Fat, lactose content are low in lactalbumin, compared with nocuousness such as excessive saturated fat, cholesterol in other animal proteins
Substance is few, it is necessary to which amino acid classes and content are complete, and nutritive value is high, is easily digested absorption, can enhance and be immunized, can prevent blood lipid
It is increased with cholesterol, it is beneficial to cardiovascular disease；The form that the mixture of pea protein and lactalbumin is used in formula, in conjunction with
Both vegetable protein and animal protein advantage, avoid the deficiency of single albumen, it is often more important that can improve carcinoma of the rectum trouble
The negative nitrogen physical condition of person.
The raw material of fat is selected from rich in soybean oil, the rapeseed oil, peanut oil, Corn Seeds based on omega-3 unsaturated fatty acid
Oil, safflower oil, perilla herb oil, samara oil, acer truncatum seed oil, peony seed oil, the one or more of common seepweed seeds oil etc. pressed with fish oil
Certain proportion composition, this collocation, which can give full play to omega-3 unsaturated fatty acid, improves membrane structure, improves cell membrane fortune
Defeated and immune function promotes the effect of T lymphocyte immune mature；In addition, these are oily by reasonably combined cheap, easy
, fatty acid composition meets special doctor's food requirement.Glutamine has significant auxiliary therapeutic action to carcinoma of the rectum patients undergoing chemotherapy, together
When can reduce the side effect of chemotherapy.By strong anti-oxidation can selective clearing free radical from the root, retain to the carcinoma of the rectum
Cell has the Superoxide anion free radical of killing effect, in addition, oxidative stress status is adjusted, can also suffer to the carcinoma of the rectum is improved
The expression of ADA, GSH, PX, CAT, SOD, MDA are conducive to patient's to adjust the physical condition of patient in person's blood plasma
Rehabilitation, the deterioration or recurrence for avoiding disease.
Compared with other function oligosaccharide, xylo-oligosaccharide has good physicochemical property and Bifidobacterium proliferation special
Property.In addition, xylo-oligosaccharide there are also inoxidizability, promote calcium uptake, enhancing immunity of organisms, reduce the carcinoma of the rectum the effects of.Red moss
Sugar alcohol, galactooligosaccharide etc. can improve the mouthfeel of diet, improve the appetite of patient, and reducing chemotherapy influences the anorexia of patient,
The depressed mood of patient can be improved after edible, while combining adjusting stomach, reductionization with pea dietary fiber, resistant starch
Treat the problems such as bring defecation is unsmooth.Hydroxypropul starch is good suspending agent, and suspending effect is good, does not glue wall, easily disperses, flocculation
Particle is fine and smooth.Maltodextrin has good dissolubility, can improve the mobility of product.
The parenteral nutrition of arginine enhancing improves the immune function of advanced rectal cancer patients undergoing chemotherapy, protects the immune of intestinal mucosa
Barrier, effect are obvious.
High protein of the present invention, Hi CHO, low fat formula are suitble to carcinoma of the rectum eater physical feature, are conducive to body
Rehabilitation at body.Nutraceutical of the invention for body other than it can provide sufficient, comprehensive nutrition, it is often more important that enhance intestines
The barrier function of mucous membrane more meets metabolic physiology state, is conducive to body protein synthesis and Metabolism regulation, promotes enteron aisle function
It can restore with form, prevent bacterium and toxin transposition, hence it is evident that the generation for reducing enterogenic infection is to improve patients undergoing chemotherapy nutrition shape
The effective means of condition.Certain improvement result can be played to the nutrition condition of Advanced Rectal Cancer patients undergoing chemotherapy, reduce patient
Adverse reaction can effectively improve the immunity of patient.
Specific embodiment
The present invention is described further with reference to embodiments.
Embodiment 1
Every hectogram carcinoma of the rectum nutraceutical nutritional ingredient is as follows: protein 37 g, fat 2.5g, carbohydrate 56.5g, vitamin A
249.42 μ g, 5.2 μ g of vitamin D, vitamin E 4mg, vitamin K1 19 μ g, vitamin B1 0.4mg, vitamin B2 0.4mg、
Vitamin B6 0.45mg, vitamin B12 1 μ g, niacin 0.915mg, 205 μ g of folic acid, pantothenic acid 2.43mg, vitamin C 7.2mg, life
15 μ g of object element, sodium 61.33mg, potassium 99.41mg, 200 μ g of copper, magnesium 73.2mg, iron 4.28mg, zinc 2.4mg, 100.13 μ g of manganese, calcium
47.12mg, phosphorus 160.01mg, 29.67 μ g of iodine, 15.07 μ g of selenium, 7.82 μ g of chromium, glutamine 100mg, arginine 150mg, silver
Flavone 150mg, phytosterol 550mg.
The raw material prepared in every hectogram nutraceutical is as follows:
Pea peptide 25g, lactalbumin 12g, soybean oil 1g, peony seed oil 0.5g, common seepweed seeds oil 0.5g, fish oil 0.5g, fructose
30g, pea dietary fiber 10g, hydroxypropul starch 10g, xylo-oligosaccharide 5g, antierythrite 1.5g, 260 μ g of retinol acetate, dimension
Raw element D25.2 μ g, D- alpha-tocotrienol 16mg, vitamin K119 μ g, 400 μ g of thiamine hydrochloride, 400 μ g of riboflavin, hydrochloric acid pyrrole
It trembles 450 μ g of alcohol, 1 μ g of cyanocobalamin, 915 μ g of niacin, 205 μ g of folic acid, D-VB5 calcium 2.7mg, L-AA 7.2mg, D- biology
15 μ g of element, sodium chloride 156mg, potassium citrate 260mg, 500 μ g of copper sulphate, magnesia 122mg, ferrous fumarate 13mg, oxidation
Zinc 3mg, 170 μ g of manganese sulfate, calcium citrate 270mg, potassium dihydrogen phosphate 702mg, 50 μ g of Potassiumiodate, 33 μ g of sodium selenite, chlorination
40 μ g of chromium, glutamine 100mg, arginine 150mg, GINKGO BILOBA EXTRACT 150mg, phytosterol 550mg.
The preparation method is as follows:
Pea peptide, lactalbumin, fructose, pea dietary fiber, hydroxypropul starch, xylo-oligosaccharide, antierythrite, acetic acid view is yellow
Ester, vitamin D2, D- α-tocopherol acetate trienol, vitamin K1, thiamine hydrochloride, riboflavin, puridoxine hydrochloride, cyanocobalamin, cigarette
Acid, folic acid, D-VB5 calcium, L-AA, D-Biotin, sodium chloride, potassium citrate, copper sulphate, magnesia, fumaric acid are sub-
Iron, zinc oxide, manganese sulfate, calcium citrate, potassium dihydrogen phosphate, Potassiumiodate, sodium selenite, chromium chloride, glutamine, arginine,
GINKGO BILOBA EXTRACT, phytosterol, sterilize 100s in the sterilizer of 500W, after sterilizing, is divided into 5 parts, forms function bag.
By soybean oil, peony seed oil, common seepweed seeds oil, fish oil sterilize in the sterilizer of 500W 100s, it is average after sterilizing
It is divided into 5 parts, forms energy bag.
Pea peptide the preparation method comprises the following steps: the pea protein of water content 25wt.% is squeezed, it is after extruding, extrudate is cold
But, dry, crush, then carry out enzyme digestion reaction with neutral proteinase, after enzyme digestion reaction, the DPPH clearance rate of pea peptide,.OH is removed
Rate, O2 .-Clearance rate is respectively 95%, 88%, 45%.
Temperature when wherein squeezing is 60 DEG C, screw speed 165r/min, and die hole aperture is 12mm；Enzymolysis temperature
It is 38 DEG C, the pH value of enzyme digestion reaction is 7, and pea protein concentration is 8.1g/mL in enzyme digestion reaction, and the dosage of neutral proteinase is pea
The 12% of legumin dosage.
Embodiment 2
Nutritional ingredient is as follows in every hectogram carcinoma of the rectum nutraceutical: albumen 40g, fat 2.6g, carbohydrate 55g, vitamin A
287.79 μ g, 10 μ g of vitamin D, vitamin E 5mg, vitamin K1 22 μ g, vitamin B1 0.45mg, vitamin B2 0.5mg、
Vitamin B6 0.6mg, vitamin B12 2 μ g, niacin 1.8mg, 400 μ g of folic acid, pantothenic acid 2.52mg, vitamin C 3.5mg, biology
12 μ g of element, sodium 64.87mg, potassium 99.415mg, 220 μ g of copper, magnesium 75mg, iron 8.56mg, zinc 2.56mg, 100.13 μ g of manganese, calcium
52.36mg, phosphorus 160.01mg, 30 μ g of iodine, 45.66 μ g of selenium, 156.4 μ g of chromium, glutamine 100mg, arginine 150mg, ginkgo
Flavones 150mg, phytosterol 400mg.
The raw material prepared in every hectogram nutraceutical is as follows:
Pea protein 20g, lactalbumin 20g, peanut oil 0.5g, Corn Seeds oil 0.5g, samara oil 0.5g, acer truncatum seed oil
0.5g, fish oil 0.6g, fructose 10g, pea dietary fiber 20g, laminarin 5g, hydroxypropul starch 5g, pea resistant starch
10g, antierythrite 5g, 300 μ g of retinol acetate, vitamin D2 10 μ g, D- alpha-tocotrienol 20mg, vitamin K1 22μg、
450 μ g of thiamine hydrochloride, 500 μ g of riboflavin, 600 μ g of puridoxine hydrochloride, 2 μ g of cyanocobalamin, 1800 μ g of niacin, 400 μ g of folic acid, D-
Calcium pantothenate 2.8mg, L-AA 3.5mg, 12 μ g of D-Biotin, sodium chloride 165mg, potassium citrate 260mg, 550 μ of copper sulphate
G, magnesia 125mg, ferrous fumarate 26mg, zinc oxide 3.2mg, 170 μ g of manganese sulfate, calcium citrate 300mg, potassium dihydrogen phosphate
702mg, 50.6 μ g of Potassiumiodate, 100 μ g of sodium selenite, 800 μ g of chromium chloride, glutamine 100mg, arginine 150mg, Gingko yellow
Ketone 150mg, phytosterol 400mg.
The preparation method is as follows:
By pea protein, lactalbumin, fructose, pea dietary fiber, laminarin, hydroxypropul starch, pea resistant starch, red
Moss sugar alcohol, retinol acetate, vitamin D2, D- alpha-tocotrienol, vitamin K1, thiamine hydrochloride, riboflavin, hydrochloric acid pyrrole tremble
Alcohol, cyanocobalamin, niacin, folic acid, D-VB5 calcium, L-AA, D-Biotin, sodium chloride, potassium citrate, copper sulphate, oxidation
Magnesium, ferrous fumarate, zinc oxide, manganese sulfate, manganese sulfate, calcium citrate, potassium dihydrogen phosphate, Potassiumiodate, sodium selenite, chlorination
Chromium, glutamine, arginine, GINKGO BILOBA EXTRACT, phytosterol, sterilize 120s in the sterilizer of 425W, after sterilizing, is divided into
5 parts, form function bag.
Peanut oil, Corn Seeds oil, samara oil, acer truncatum seed oil, fish oil are sterilized 120s in the sterilizer of 425W, sterilizing
Afterwards, 5 parts are divided into, energy bag is formed.
Claims (10)
1. a kind of carcinoma of the rectum nutraceutical, it is characterised in that nutritional ingredient is as follows in every hectogram nutraceutical: albumen 34g-58g,
Fatty 1.3g-4g, carbohydrate 34g-60g, 159 μ g-889 μ g of vitamin A, 4 μ g-13 μ g of vitamin D, vitamin E
4mg-50mg, vitamin K1 17 μ g-185 μ g, vitamin B1 330 μ g-1mg, vitamin B2 332 μ g-1mg, vitamin B6 332μ
G-1mg, vitamin B12 1 μ g-20 μ g, niacin 0.9mg-8mg, 88 μ g-608 μ g of folic acid, pantothenic acid 2mg-20mg, vitamin C
3mg-7.2mg, 9 μ g-85 μ g of biotin, sodium 60mg-70mg, potassium 46mg-135mg, 182 μ g-230 μ g of copper, magnesium 73mg-100mg,
Iron 4mg-9mg, zinc 2mg-4.8 mg, 99 μ g-130 μ g of manganese, calcium 35mg-60mg, phosphorus 159mg-164mg, 27 μ g-50 μ g of iodine, selenium
13 μ g-91 μ g, 7 μ g-228 μ g of chromium, glutamine 60mg-106mg, arginine 100mg-150mg, GINKGO BILOBA EXTRACT 100mg-
150mg, phytosterol 300mg-560mg.
2. a kind of carcinoma of the rectum nutraceutical as described in claim 1, it is characterised in that:
The raw material of albumen is selected from pea protein and lactalbumin, or is selected from pea peptide and lactalbumin；
The raw material of fat is selected from fish oil and soybean oil, rapeseed oil, peanut oil, Corn Seeds oil, safflower oil, perilla herb oil, samara oil, member
Precious maple seed oil, peony seed oil, common seepweed seeds oil etc. one or more；
The raw material of carbohydrate be selected from xylo-oligosaccharide, galactooligosaccharide, fructose, antierythrite, laminarin, maltodextrin,
One of hydroxypropul starch, dietary fiber or resistant starch are a variety of.
3. carcinoma of the rectum nutraceutical according to claim 1, it is characterised in that:
The raw material of vitamin A is selected from one of retinol acetate, retinyl palmitate or beta carotene or a variety of；
The raw material of vitamin D is selected from vitamin D2, vitamin D3One or both of；
The raw material of vitamin E is selected from D- alpha-tocotrienol, dl-α-tocopherol acetate trienol, dl-alpha-tocotrienol, dimension
One of raw element E calcium succinate is a variety of；
Vitamin B1Raw material be selected from one or both of thiamine hydrochloride, Thiamin mononitrate；
Vitamin B2Raw material be selected from one or both of riboflavin or riboflavin 5 '-sodium phosphate；
Vitamin B6Raw material be selected from puridoxine hydrochloride；
Vitamin B12Raw material be selected from cyanocobalamin；
The raw material of niacin is selected from one or both of niacin or niacinamide；
The raw material of pantothenic acid is selected from D-VB5 calcium；
Ascorbic raw material is in L-AA, L-AA sodium, L-AA calcium or ascorbyl palmitate
It is one or more；
The raw material of biotin is selected from D-Biotin.
4. carcinoma of the rectum nutraceutical according to claim 1, it is characterised in that:
The raw material of sodium is selected from sodium chloride；
The raw material of potassium is selected from one of dipotassium hydrogen phosphate, potassium dihydrogen phosphate, potassium chloride or potassium citrate or a variety of；
The raw material of copper is selected from one or both of copper sulphate or copper gluconate；
The raw material of magnesium is selected from one of magnesium carbonate, magnesium sulfate, magnesia, magnesium chloride or L- magnesium threonate or a variety of；
The raw material of iron is selected from one of ferrous gluconate, ferrous fumarate, ferrous sulfate, ferrous lactate or ferrous succinate
Or it is a variety of；
The raw material of zinc is selected from zinc sulfate, zinc citrate, zinc citrate (three water), zinc gluconate, zinc oxide or zinc lactate
It is one or more；
The raw material of manganese is selected from one or both of manganese sulfate or manganese gluconate；
The raw material of calcium is selected from calcium carbonate, calcium acetate, calcium chloride, calcium citrate, calcium gluconate, calcium lactate, calcium monohydrogen phosphate, phosphoric acid
One of calcium dihydrogen, tricalcium phosphate (calcium phosphate), calcium sulfate, L-calcium lactate or calcium glycerophosphate are a variety of；
The raw material of phosphorus is selected from potassium dihydrogen phosphate；The raw material of iodine is selected from Potassiumiodate；
The addition form of selenium is one of sodium selenite, Se-enriched yeast or L- selenium-methyl selenium substituted aminothiopropionic or a variety of；
The raw material of chromium is selected from chromium chloride.
5. carcinoma of the rectum nutraceutical according to claim 2, it is characterised in that: pea peptide the preparation method comprises the following steps: by aqueous
The pea protein of amount 25wt.% is squeezed, after extruding, extrudate is cooling, dry, crushing, then enzyme is carried out with neutral proteinase
Solution reaction.
6. carcinoma of the rectum nutraceutical according to claim 5, it is characterised in that: enzymolysis temperature is 38 DEG C, and enzymatic hydrolysis is anti-
The pH value answered is 7, and pea protein concentration is 8.1g/mL in enzyme digestion reaction, and the dosage of neutral proteinase is pea protein dosage
12%；After enzyme digestion reaction, the DPPH clearance rate of pea peptide,.OH clearance rate, O2 .-Clearance rate is respectively 95%, 88%, 45%.
7. a kind of preparation method of carcinoma of the rectum nutraceutical described in claim 1, it is characterised in that: with carcinoma of the rectum nutraceutical
100 grams of quality meters, by albumen, carbohydrate, vitamin A, vitamin D, vitamin E, vitamin K1, vitamin B1, vitamin
B2, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid, vitamin C, biotin, sodium, potassium, copper, magnesium, iron, zinc, manganese, calcium,
Phosphorus, iodine, selenium, chromium, glutamine, arginine, GINKGO BILOBA EXTRACT, phytosterol nutritional ingredient raw material sterilizing after, be divided into 5
Part, form function bag；
After the raw material sterilizing of lipid nutrition ingredient, 5 parts are divided into, energy bag is formed.
8. the preparation method of carcinoma of the rectum nutraceutical according to claim 7, it is characterised in that: sterilizing power is 400-
500W, sterilization time 100-120s.
9. a kind of eating method of carcinoma of the rectum nutraceutical described in claim 1, it is characterised in that:
The age of target group is 18-64 years old, does not include pregnant woman and breast feeding women；
Dosage are as follows: 0.4 bag/(kgd), total amount is no more than 27 bags；
It is edible according to one of following two method:
(1) it is cooled to 40-60 DEG C with the boiled water of 100-400mL, the nutriment in function bag and energy bag is added, stirs, shake
After even, directly drink or taken in through tube feed；
(2) nutriment in function bag is added in the diet without containing salt and is eaten, contained in diet
Fat is consistent with the fat content in energy bag.
10. a kind of marketing method of carcinoma of the rectum nutraceutical described in claim 1, it is characterised in that: marketing method is obstructed
Hospital, supermarket or pharmacy are crossed, consumer is distributed directly to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810433939.5A CN108936597A (en) | 2018-05-08 | 2018-05-08 | A kind of carcinoma of the rectum nutraceutical and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810433939.5A CN108936597A (en) | 2018-05-08 | 2018-05-08 | A kind of carcinoma of the rectum nutraceutical and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108936597A true CN108936597A (en) | 2018-12-07 |
Family
ID=64499842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810433939.5A Withdrawn CN108936597A (en) | 2018-05-08 | 2018-05-08 | A kind of carcinoma of the rectum nutraceutical and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108936597A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108936622A (en) * | 2018-07-24 | 2018-12-07 | 山东圣海保健品有限公司 | Double protein intestinal cancer nutraceutical and preparation method thereof |
| CN110638042A (en) * | 2019-11-04 | 2020-01-03 | 光明乳业股份有限公司 | Full-nutrition formula food and application thereof |
| CN112262982A (en) * | 2020-10-22 | 2021-01-26 | 刘昌峨 | Functional food for assisting in repairing digestive tract mucosa after chemotherapy and application thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1439299A (en) * | 2003-03-18 | 2003-09-03 | 华瑞制药有限公司 | Intestinal absorbing fully nutrient emulsion for phymatostio patient |
| CN103330215A (en) * | 2013-07-11 | 2013-10-02 | 西安力邦临床营养有限公司 | Nutrition formula food applicable to tumor patient |
| CN106011211A (en) * | 2016-08-08 | 2016-10-12 | 烟台双塔食品股份有限公司 | Method for preparing pea protein polypeptide powder |
| CN106075384A (en) * | 2016-06-17 | 2016-11-09 | 天津科技大学 | Semen Pisi sativi bioactive peptide application in anticancer grows and preparation method thereof |
| CN106260498A (en) * | 2016-08-08 | 2017-01-04 | 山东理工大学 | The manufacture method of a kind of Semen Pisi sativi protein peptide and application |
| CN107080263A (en) * | 2017-04-28 | 2017-08-22 | 安徽生物肽产业研究院有限公司 | A kind of bionic enzymatic prepares the production method of pea Gly-His-Lys |
| CN107440088A (en) * | 2016-06-01 | 2017-12-08 | 华仁药业股份有限公司 | Improve operation, the nutrients and preparation method thereof of chemicotherapy tumor patient immunity |
-
2018
- 2018-05-08 CN CN201810433939.5A patent/CN108936597A/en not_active Withdrawn
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1439299A (en) * | 2003-03-18 | 2003-09-03 | 华瑞制药有限公司 | Intestinal absorbing fully nutrient emulsion for phymatostio patient |
| CN103330215A (en) * | 2013-07-11 | 2013-10-02 | 西安力邦临床营养有限公司 | Nutrition formula food applicable to tumor patient |
| CN107440088A (en) * | 2016-06-01 | 2017-12-08 | 华仁药业股份有限公司 | Improve operation, the nutrients and preparation method thereof of chemicotherapy tumor patient immunity |
| CN106075384A (en) * | 2016-06-17 | 2016-11-09 | 天津科技大学 | Semen Pisi sativi bioactive peptide application in anticancer grows and preparation method thereof |
| CN106011211A (en) * | 2016-08-08 | 2016-10-12 | 烟台双塔食品股份有限公司 | Method for preparing pea protein polypeptide powder |
| CN106260498A (en) * | 2016-08-08 | 2017-01-04 | 山东理工大学 | The manufacture method of a kind of Semen Pisi sativi protein peptide and application |
| CN107080263A (en) * | 2017-04-28 | 2017-08-22 | 安徽生物肽产业研究院有限公司 | A kind of bionic enzymatic prepares the production method of pea Gly-His-Lys |
Non-Patent Citations (3)
| Title |
|---|
| 于新等主编: "《天然食品添加剂》", 31 March 2014, 北京：中国轻工业出版社 * |
| 孙桂菊等主编: "《护理营养学》", 31 December 2013, 南京：东南大学出版社 * |
| 牙韩清等: "谷氨酰胺、精氨酸强化的全胃肠外营养对结直肠癌术后患者免疫功能的影响", 《肿瘤防治研究》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108936622A (en) * | 2018-07-24 | 2018-12-07 | 山东圣海保健品有限公司 | Double protein intestinal cancer nutraceutical and preparation method thereof |
| CN110638042A (en) * | 2019-11-04 | 2020-01-03 | 光明乳业股份有限公司 | Full-nutrition formula food and application thereof |
| CN112262982A (en) * | 2020-10-22 | 2021-01-26 | 刘昌峨 | Functional food for assisting in repairing digestive tract mucosa after chemotherapy and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6413545B1 (en) | Diet composition and method of weight management | |
| US7238373B2 (en) | Nutritional supplement | |
| CN108936595A (en) | Colon cancer nutraceutical and preparation method thereof | |
| CN108185437A (en) | A kind of full nutrient formulation powder of tumour and preparation method thereof | |
| JP2006327970A (en) | Digestive apparatus agent and anti-stress agent | |
| CN105433201A (en) | Staple food flour with balanced nutrition and preparation method of staple food flour | |
| CN110226744A (en) | A kind of prostatitis tailored version clinical nutrition formula and preparation method thereof | |
| CN108936597A (en) | A kind of carcinoma of the rectum nutraceutical and preparation method thereof | |
| JP2010254619A (en) | Nutritional supplement and gastrointestinal preparation | |
| CN108719977A (en) | A kind of breast cancer nutraceutical and preparation method thereof | |
| CN108391811A (en) | A kind of tumour full nutrition formula food and its application | |
| EP3638270B1 (en) | Compositions and methods for enhancing hyperthermia therapy | |
| CN110742267B (en) | Total-nutrient formula food for inflammatory bowel diseases | |
| JP4553224B2 (en) | healthy food | |
| CN110214942A (en) | A kind of hyperthyroidism tailored version Nutrition formula and preparation method thereof | |
| US20110165291A1 (en) | Nutritional supplement | |
| CN108936596A (en) | Lung cancer nutraceutical and preparation method thereof | |
| CN106666752A (en) | Donkey-hide gelatin composition and preparation method thereof | |
| JP2007244325A (en) | New health food | |
| CN108813576A (en) | A kind of gastric cancer nutraceutical and preparation method thereof | |
| JP4858889B2 (en) | Nutrient, digestive | |
| CN108851037A (en) | A kind of preparation method and its usage of nephrotic syndrome wholefood | |
| CN108936622A (en) | Double protein intestinal cancer nutraceutical and preparation method thereof | |
| CN108936623A (en) | Double protein gastric cancer full nutrition formula food and preparation method thereof | |
| CN108378377A (en) | The preparation method and applications of cervical carcinoma full nutrition formula food |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181207 |
|
| WW01 | Invention patent application withdrawn after publication |