JP2010254619A - Nutritional supplement and gastrointestinal preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To ameliorate malnutrition and digestive organ insufficiency by administering a nutritional supplement or a gastrointestinal preparation, containing isoflavone and/or isoflavone glucoside, a hot-taste material, a bitter-taste material or an acid-taste material, Tienchi ginseng, and cholic acid, and/or scymnol and/or a scymnol ester. <P>SOLUTION: The nutritional supplement and the gastrointestinal preparation include isoflavone and/or isoflavone glucoside, hot-taste material, bitter-taste material or acid-taste material, Tienchi ginseng, and cholic acid, and/or scymnol and/or scymnol ester. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  This invention relates to a new nutrient and digestive agent.

The fulfillment of will in the brain, that is, the fulfillment of energy, is governed by serotonin and noradrenaline, which are called brain hormones. Is activated by adrenaline.
Serotonin, noradrenaline, and adrenaline are called biological monoamines. Most monoamines that are secreted by oxidative degradation by the enzyme monoamine oxidase within a maximum of 3 hours or reabsorbed into nerve tissue lose their action. .
This is a clever human body mechanism to prevent fatigue because monoamines cause fatigue by acting for a long time.
By the way, Qi refers to all functions of the human body, but the functions are roughly divided into two types. One of them is the function of each organ, hormone secretion, blood vessels, etc., which is controlled by the autonomic nerve. The other is the function of brain thinking and voluntary muscles that move by commands issued by brain thinking.
It has been pointed out early that the qi expressed by reassurance and morality in Chinese medicine only refers to the function of the autonomic innervation of the former. The command to show how much of these functions is issued from the medulla at the bottom of the brain. Considering that the function of all autonomic innervation is activated rather than activating only a specific organ or organ with an adiabatic agent, the point of action of the adiabatic agent is not the organ or organ but the command source It is considered to be a medulla oblongata. In other words, the action of the aspirating drug is to promote the transmission of commands from the medulla and the enhancement of its transmission. We have found that ablative drugs cause the blood in the body to be unevenly distributed in organs, etc., and this is also one of the important actions of medulla oblongata, which acts for vasoconstriction and dilation, leading to the autonomic nervous system It is achieved by expanding blood vessels and constricting blood vessels toward the brain and brain-regulated organs, and aims to send more nutrients to the necessary parts as a side effect of the aerobic agent.
The inventors have so far made a nutritional agent, digestive agent, health food containing cholic acid, isoflavone and / or isoflavone glycoside (Japanese Patent Laid-Open No. 2002-205998, Japanese Patent Laid-Open No. 2002-204672, Chinese Patent No. ZL01123150.5). U.S. Pat. No. 6,793,943, European Patent No. 1198994), nutrients, digestives, and health foods containing simnole and / or simnol esters, isoflavones and / or isoflavone glycosides 255823, JP 2002-253169, Chinese Patent No. ZL01123149.1), isoflavones and / or isoflavone glycosides, pungent substances, bitter substances or sour substances, in particular curcumin and cholic acid, and / or simanol and / or Nutrients containing simanol esters Developed gastrointestinal and health food (JP 2004-123671, JP 2003-245054, Chinese Patent ZL02128298.6, Chinese Patent ZL02157491.X, European Patent 12813324, Chinese Patent ZL02157443.X) However, it has been found that the addition of the seven ginsengs has a further excellent effect, and the present invention has been completed.
In other words, the “blood-blooded water” mainly composed of curcumin, isoflavone, and simnol described in the “Healthy Blood Water Health Law” (Oura Miura, Kenkichi Okada, Toseisha Co., Ltd., issued on February 30, 2005). It has been found that by adding ginseng, it has an extremely excellent effect on digestive diseases.

JP 2002-205998 JP 2002-204672 A JP 2002-255823 A JP 2002-253169 A JP 2004-123671 A JP 2003-245054 A Chinese Patent No. ZL01123150.5 US Pat. No. 6,793,943 European Patent No. 1198994 Chinese Patent No. ZL01123149.1 Chinese Patent No. ZL02128298.6 Chinese Patent No. ZL02157491. X European Patent No. 1281324 Chinese Patent No. ZL02157443. X

Various symptoms occur with age.
The cause of these disorders is due to insufficient transmission of brain commands to the local area, and is a trouble that occurs due to a blood circulation disorder.
The invention of this application is intended to treat malnutrition and gastrointestinal insufficiency caused by such troubles, and in particular to treat Crohn's disease, ulcerative colitis, irritable colitis and diarrhea. With the goal.
It has been pointed out that hypersensitivity / ulcerative colitis and Crohn's disease, which have been prominently increasing in recent years, have been changed to colon cancer in the long-term prognosis.

  The invention of this application is characterized by comprising isoflavone and / or isoflavone glycoside, pungent substance, bitter substance or sour substance, ginseng, cholic acid, and / or simanol and / or simanol ester The present invention relates to a nutritional agent and a digestive agent, particularly a drug having an excellent effect in treating Crohn's disease, ulcerative colitis, irritable colitis and diarrhea.

  The invention of this application relates to the administration of isoflavones and / or isoflavone glycosides, pungent substances, bitter substances or sour substances, ginseng, cholic acid, and / or simanol and / or simanol esters. Due to the synergistic action, there is an excellent effect that it is possible to provide a nutritional agent and a digestive agent that can treat and prevent malnutrition and digestive failure earlier. In particular, it has an excellent effect of being able to treat and prevent Crohn's disease, ulcerative colitis, irritable colitis and diarrhea more quickly.

The invention of this application is only required to contain a pungent substance, a bitter substance or a sour substance, but preferably contains isoflavones and isoflavone glycosides, and the isoflavones and isoflavone glycosides are soybeans contained in soybeans. Isoflavones and soy isoflavone glycosides are particularly preferred.
Moreover, when using isoflavone and an isoflavone glycoside, it is preferable to add cholic acid.

  The daily dose of isoflavone and isoflavone glycoside is preferably 1 to 500 mg, more preferably 5 to 200 mg, and particularly preferably 10 to 100 mg.

トウガラシのカプサイシン、

コショウのピペリン、

ショウガのジンゲロン、

ショウガの［６］−ショーガオール、

ショウガの［６］−ジンゲロール

であることが好ましく、クルクミンがとくに好ましい。
苦味物質は、スウェルチアマリン、ゲンチオピクリン、ロガニンが好ましい。
また、酸味物質は、クエン酸、乳酸が好ましい。 The pungent substance, bitter substance or sour substance of the present invention is preferably a pungent substance.
The pungent substance is turmeric curcumin,

Capsicum capsicum,

Pepperine with pepper,

Ginger gingeron,

Ginger [6]-Shogaol,

[6] -gingerol of ginger

And curcumin is particularly preferred.
The bitter substance is preferably swell thiamarin, gentiopicrin, or loganin.
The sour substance is preferably citric acid or lactic acid.

The daily dose of the pungent substance is preferably 1 to 1000 mg, more preferably 5 to 300 mg, and particularly preferably 10 to 70 mg.
In addition, the daily dose when used in combination with a Chinese medicine preparation or Chinese medicine having a correcting effect such as Juzentaihoto is preferably 100 to 200 mg.

  The daily dose of cholic acid is preferably 1 to 1000 mg, more preferably 2 to 300 mg, and particularly preferably 10 to 100 mg.

  The daily dose of simnole and / or simnol ester is preferably 0.1 to 100 mg, more preferably 0.1 to 50 mg, and particularly preferably 0.3 to 10 mg.

  The daily dose of the ginseng is preferably 0.1 to 3000 mg, more preferably 1 to 2500 mg, and particularly preferably 5 to 2000 mg.

As other ingredients, pharmaceuticals in general are used, and vitamins, antibiotics, anticancer agents, heme iron, prune extract, and crude drugs are used.
Preferred crude drugs are those that have a correcting effect, such as those that activate the functions of organs, glands and blood vessels that are governed by autonomic nerves, and those that aid digestion.

More than ten kinds of herbal medicines that activate the functions of organs, glands, and blood vessels controlled by autonomic nerves are known. For example, there are apricots, carrots and others, but some active ingredients of these herbal medicines including carrots are It has already been revealed.
Therefore, it is preferable to add these active ingredients. By further adding these active ingredients, the human body function activating effect can be exhibited.
Such herbal medicines include: Akagi, carrots, ginseng, ginseng, taishin, western ginseng, yellow ginseng, birch jutsu, and sanyaku. Licorice, licorice, koji, yellow spirit, quail, etc. are particularly preferred.

  In addition, it is particularly preferable to add hawthorn, shinki (kurin), life comb, malt (bakuga), cereal (kokuga), chicken inner gold (keinaikin), ahi (agi), etc., which are herbal medicines that aid digestion.

また、シムノール硫酸エステルナトリウム塩はつぎの構造式で表される。

Simnole and / or Simnol ester is contained in the bile of salmon.
Simnol is represented by the following structural formula:

Simnol sulfate sodium salt is represented by the following structural formula.

Another material used in the invention of this application is isoflavone and isoflavone glycoside.
The active ingredients for this purpose contained in soybeans are several isoflavone glycosides such as soybean in (Gaidin), glycitin (Glycitin), genistin (Gaistin) and the like, and their aglycones (Daizein), glycitein There are several isoflavones such as (Glycitein) and Genistein.
Soybean is a raw material for producing soybean oil, but the demand for soybean oil is large, and soybean meal, a by-product of the soybean oil, is produced in large quantities at the same time. A part of soybean meal is used as a raw material for producing soybean protein as a raw material for food, but it is mainly used as fertilizer and feed, and its price is extremely low. Soybean isoflavone and soybean isoflavone glycosides can be produced with high purity and low cost from soybean meal that is close to industrial waste.

  In the invention of this application, inosinic acid is preferably added.

The invention of this application preferably adds odd fatty acids.
As the odd fatty acid, tridecanoic acid, pentadecanoic acid, heptadecanoic acid, and nonadecanoic acid are preferable, and pentadecanoic acid and heptadecanoic acid are particularly preferable.

Although it does not specifically limit as a dosage form which administers the nutrient agent and digestive organ agent of this application invention, It administers as an internal medicine, a suppository, an injection, etc., such as a tablet, a powder agent, a solid agent, and a liquid agent.
In addition, excipients such as lactose and starch, vegetable oils, and others are used.

Hereinafter, the present invention will be described in detail.
The purity of the soy isoflavone and soy isoflavone glycoside used was 40%.
Moreover, the purity of cholic acid used other than a pure product is 90%.

Example 1
Tablet curcumin 25mg
Simnole 1mg
Soy isoflavone 250mg
Tanachi Ginseng powder 2000mg
Lactose 886mg
Crystalline cellulose appropriate amount Carboxymethylcellulose calcium 320mg
Hydroxypropylcellulose 558mg
Carplex 30mg
Magnesium stearate 55mg
Total 5600mg
(1 tablet, 280 mg, 5 tablets, 2 times a day)
Similarly, tablets were made using soy isoflavone glycosides instead of soy isoflavones.

Example 2
Soft capsule curcumin 25mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Ginseng extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)
Similarly, soft capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Example 3
Drink curcumin 30mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Ginseng extract 10mg
Giant extract 10mg
Royal Jelly 100mg
Thiamine nitrate 10mg
Riboflavin sodium phosphate 5mg
Pyridoxine hydrochloride 10mg
Anhydrous caffeine 50mg
Ethanol 1.2mL
Ethyl paraoxybenzoate 4mg
Purified water
Total 50 mL bottle Similarly, a drink was prepared using soy isoflavone glycoside instead of soy isoflavone.

Example 4
Drink curcumin 30mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Nana ginseng extract 1500mg
Longan Extract 100mg
Garbage extract 300mg
Royal Jelly 150mg
Riboflavin sodium phosphate 10mg
Ethanol 1.2mL
Paraoxybenzoic acid 4mg
Purified water appropriate amount total 50ml
Similarly, a drink was prepared using soy isoflavone instead of soy isoflavone glycoside.

Example 5
Soft capsule curcumin 25mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Heptadecanoic acid 30mg
Inosinic acid 100mg
Ginseng extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)
Similarly, soft capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Example 6
Tablet curcumin 30mg
Simnole 1mg
Soy isoflavone 250mg
Tanachi Ginseng powder 2000mg
Agoe powder 1000mg
Lactose 886mg
Crystalline cellulose appropriate amount Carboxymethylcellulose calcium 320mg
Hydroxypropylcellulose 558mg
Carplex 30mg
Magnesium stearate 55mg
Total 5600mg
(1 tablet, 280 mg, 5 tablets, 2 times a day)
Similarly, tablets were made using soy isoflavone glycosides instead of soy isoflavones.

Example 7
Soft capsule curcumin 30mg
Simnol sulfate Na 1mg
Soy isoflavone 40mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Ginseng extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)
Similarly, soft capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Example 8
Drink curcumin 30mg
Simnol sulfate Na 1mg
Soy isoflavone 40mg
Ginseng extract 10mg
Giant extract 10mg
Royal Jelly 100mg
Thiamine nitrate 10mg
Riboflavin sodium phosphate 5mg
Pyridoxine hydrochloride 10mg
Anhydrous caffeine 50mg
Ethanol 1.2mL
Ethyl paraoxybenzoate 4mg
Purified water
Total 50 mL bottle Similarly, a drink was prepared using soy isoflavone glycoside instead of soy isoflavone.

Example 9
Drink curcumin 30mg
Cholic acid 60mg
Soy isoflavone glycoside 40mg
Nana ginseng extract 1500mg
Longan Extract 100mg
Garbage extract 300mg
Royal Jelly 150mg
Riboflavin sodium phosphate 10mg
Ethanol 1.2mL
Paraoxybenzoic acid 4mg
Purified water appropriate amount total 50ml
Similarly, a drink was prepared using soy isoflavone instead of soy isoflavone glycoside.

Example 10
Soft capsule curcumin 30mg
Simnol sulfate Na 1mg
Soy isoflavone 40mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Heptadecanoic acid 30mg
Inosinic acid 100mg
Ginseng extract 200mg
Agomi extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)
Similarly, soft capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Although no studies have been conducted on the effects of curcumin, gingeron, and shogaol on promoting adrenaline secretion, animal experiments using sputum showed a marked increase in blood glucose concentration, confirming the existence of an adrenaline secretion promoting action. It was.
The effects of the present invention are as follows.

(Table 1)
Number of cases Dropped out Number of effective cases Remarkable effect Invalid Invalid side effect discontinuation 1) Kron's disease 1 0 1 1 0 0 0
2) Ulcerative colitis 3 0 3 2 1 0 0
3) Irritable colitis 9 0 9 3 2 1 3
4) Diarrhea 18 2 16 6 7 1 2
Total 31 2 29 12 10 2 5

Note: 1) to 3) are patients who visited the hospital after receiving an intractable disease designation at another clinic.
4) is a case of refractory “diarrhea, constipation, and diarrhea” that has not been diagnosed.
1, 12 effective cases, 10 effective cases, and 2 ineffective cases were obtained for 29 effective cases aimed at “refractory interest and constipation and bloody stagnation”, which were repeatedly refractory.
2. Side effects were 5 cases such as constipation, increased blood pressure, tinnitus, abdominal pain.
3. The average administration period until the effect was exhibited was about 5 to 7 days, which was a very short period.
The 4 or 2 dropout cases have the potential for ineffectiveness or side effects.
5. Two cases of ulcerative colitis that had improved significantly both endoscopically and subjectively had difficulty in renewing the designation of intractable disease.

  The invention of this application is an excellent nutrient containing isoflavone and / or isoflavone glycoside, pungent substance, bitter substance or sour substance, ginseng and cholic acid, and / or simanol and / or simanol ester, Provide digestive agents, especially digestive agents.

Claims (12)

Nutrient, digestive organ characterized by containing isoflavone and / or isoflavone glycoside, pungent substance, bitter substance or sour substance, red ginseng, cholic acid, and / or simanol and / or simanol ester Agent. The nutrient and digestive agent according to claim 1, wherein the isoflavone and the isoflavone glycoside are soybean isoflavone and soybean isoflavone glycoside. The nutritive or digestive agent according to claim 1 or 2, wherein the pungent substance, bitter substance or sour substance is food. The nutritive agent and digestive organ according to any one of claims 1 to 3, wherein the pungent substance, bitter substance or sour substance is a pungent substance. The nutritive and digestive agent according to any one of claims 1 to 4, wherein the pungent substance is curcumin. A nutrient and digestive organ according to any one of claims 1 to 5, wherein a vitamin preparation is added. A nutritional agent and a digestive organ agent according to any one of claims 1 to 6, wherein a crude drug is added. The nutrient and digestive system according to claim 7, wherein the crude drug has a corrective effect. Herbal medicines include Aki, Ginseng, Ginseng, Taishin, Taijin, Western ginseng, Ogi, Biakujutsu, Sanyaku, Licorice ), Daisou, Koi, Yellow spirit, Yotsudan, Shiojijin, Nutritional and digestive agents according to claim 8. The herbal medicine is one or more of hawthorn, Shinki, life comb, malt (Bakuga), cereal (Kokuga), chicken inner gold (Kainaikin), and Aki (Agi). The nutrients and digestive agents described in 1. Inosinic acid is added, The nutrient and digestive organ according to any one of claims 1 to 10. An odd number fatty acid is added, The nutrient and digestive organ agent in any one of Claims 1-11 characterized by the above-mentioned.