JP2007246470A - New medicine - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medicine such as a nutrient agent, a gastrointestinal medicine, a muscle-strengthening agent, an anti-inflammatory preparation, a cerebral infarction sequela medicine, a motor paralysis medicine, an anti-asthmatic agent, a decreased vision medicine, an antidepressant preparation, a menopausal disorder medicine, an anti-senile dementia medicine, a stress gastritis-preventing/treating agent, an infertility medicine, a bowel movement-promoting agent, an internal hemorrhage medicine, a diuretic, an anticancer agent, or a medicine for skins, and to provide a cosmetic effective for bleaching, wrinkles, spots, hair growth, hair restoration, and so on. <P>SOLUTION: This medicine contains a large amount of a pungent substance, bitter substance or sour taste substance. Especially, a medicine contains a large amount of curcumine as a pungent substance. The dose of the curcumine a day is 100 to 1,000 mg, especially preferably 150 to 250 mg, and is preferably 0.01 to 0.1%, in the case of an external preparation. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a new drug containing a large amount of curcumin as an active ingredient.

Traditional Chinese medicine is based on keeping the body always in a normal state, but there is a concept of “blood and blood” to achieve that purpose, and there are also concrete means based on that concept. Something has been known for a long time.
However, the concept is explained in a philosophical expression peculiar to China, and it is a concept that is difficult to understand and unacceptable in the world of scientific civilization, where only natural materials are dried. Therefore, valuable traditional Chinese medicine was also rarely used outside China.
April 1999, Vol. Of Chinese Journal of Information on Traditional Chinese Medicine (Chinese Journal of Information on Traditional Chinese Medicine), a Chinese medical institution magazine. 6 No. On the fourth day, a sentence titled “The world's promising Chinese medicine-therapeutic medicine research method” was published.
This paper explains the part related to science that was included in the concept of “blood and blood” using the language of science, which is the world's common language.
Briefly explaining the science included in the concept of blood, blood, and water, the science included in the word “ki” means that all functions of the human body are firmly activated, and “blood” The term “science” refers to the supply of substances necessary for performing these functions throughout the body through blood vessels, and the term “water” refers to the science of blood vessels. It is to supply the necessary substances transported in (1) enough even to the part without blood vessels, but the transportation path of the necessary substances at this time is the flow of moisture formed from the inside of the body to the outside .
The fact that a completely new scientific concept has been expressed as a medical theory included in Chinese traditional medicine is that many existing scientific theories have shown infinite development at the same time as its manifestation. Providing a new medical method to the world and presenting for the first time the possibility of concretely realizing prevention of disease, enhancement of natural healing power, promotion of post-morbid recovery, etc. Yes.
Furthermore, this new medical theory makes it very easy to determine the active ingredients to achieve the medical theoretical part contained in each herbal medicine traditionally used as material in Chinese traditional medicine, and as a result All materials used in the realization of new medical theories can be made active ingredients with high purity.
The fulfillment of will in the brain, that is, the fulfillment of energy, is governed by serotonin and noradrenaline, which are called brain hormones. Is activated by adrenaline.
Serotonin, noradrenaline, and adrenaline are called biological monoamines. Most monoamines that are secreted by oxidative degradation by the enzyme monoamine oxidase or reabsorbed into nerve tissues within a maximum of 3 hours lose their action. .
This is a clever human body mechanism to prevent fatigue because monoamines cause fatigue by acting for a long time.
The onset of depression occurs due to a decrease in the ability to secrete these biological monoamines, maintaining a depressed state lacking will and vitality, and sometimes lowering the spirit until a strong desire for suicide occurs.
Until now, as a treatment for depression, drugs that suppress the action of monoamine oxidase or drugs that prevent reabsorption of these monoamines have been administered to maintain the concentration of these monoamines whose secretory capacity has been reduced. Reactive symptomatic treatment to prevent the extreme decline of
However, since this therapy is not a fundamental therapy aimed at eliminating the cause of the onset of decreased secretion of biological monoamines, it can only be expected that the monoamine secretion capacity will naturally recover during long-term symptomatic treatment. It is.
The natural recovery is a therapy that has the disadvantage of not only further weakening the ability to secrete monoamine due to the constant presence of monoamine, but also causing a decrease in physical strength due to fatigue due to excessive combustion of sugar and lipid by adrenaline.
By the way, Qi refers to all functions of the human body, but the functions are roughly divided into two types. One of them is the function of each organ, hormone secretion, blood vessels, etc., which is controlled by the autonomic nerve. The other is the function of brain thinking and voluntary muscles that move by commands issued by brain thinking.
It has been pointed out early that the qi expressed by reassurance and morality in Chinese medicine only refers to the function of the autonomic innervation of the former. The command to show how much of these functions is issued from the medulla at the bottom of the brain. Considering that the function of all autonomic innervation is activated rather than activating only a specific organ or organ with an adiabatic agent, the point of action of the adiabatic agent is not the organ or organ but the command source It is considered to be a medulla oblongata. In other words, the action of the aspirating drug is to promote the transmission of commands from the medulla and the enhancement of its transmission. The inventor of this application has found that the aspirating drug is unevenly distributed in the body blood in the organ, etc., which is also one of the important actions of the medulla oblongata, the action of vasoconstriction and dilation works, the autonomic innervation system This is achieved by expanding the blood vessels toward the brain and constricting the blood vessels toward the brain and brain-regulated organs, aiming to send more nutrients to the necessary parts as a side effect of the aspirating drugs. .
Depression was once a rare disease, but the incidence of depression in countries around the world has been increasing in recent years, and it is said that one in every 150 people in Tokyo is a patient with depression.
Recently, an interesting view of the cause of this increased incidence of depression has been published.
In other words, except for some regional conflicts, the world is far from the danger of war, the social order is improved, the chances of encountering unexpected accidents are reduced, and it is almost unnecessary for the human body to prepare for the danger and improve the energy. ing.
For this reason, the need for the secretion of biogenic amines has been extremely reduced, and it is the theory that depression has become easier to develop as a result of the degeneration of the secretory ability.
If this theory is correct, if the artificial monoamine secretion promotion means is taken once a day artificially, for example, depression can be prevented. The secretory ability is restored, and there is a possibility of recovery from depression.
Also, as the age increases, anal prolapse and pain in the legs, lower back, and arms occur, but it has been understood only because of local blood circulation disorders or the resulting inflammation, but sufficient removal of the blood circulation disorders The improvement of these conditions was insufficient with single use of powerful drugs alone.
The cause of these disorders is due to inadequate transmission of brain commands to the local area, and blood circulation disorders and inflammation are troubles that occur because muscles cannot move normally due to incomplete transmission of brain commands.
Not all muscle disorders are due to insufficient brain command transmission, but most of the disorders are thought to be due to insufficient brain command transmission. In particular, we found that muscle disorders such as low back pain and limb pain that occur with aging can be easily removed by improving brain command transmission by curcumin.
The inventors of the present application have already developed the following inventions for these, but further research has made it even better by administering a large amount of pungent substance, bitter substance or sour substance, especially a large amount of curcumin. I found out that the effect was obtained.
JP 2002-205998 (Claims) JP 2003-113117 (Claims) JP 2003-123671 (Claims) JP 2004-182599 (Claims)

  This invention of the present application has been developed based on this new medical theory and aims to provide a new drug.

The invention of the present application relates to a drug containing a large amount of pungent substance, bitter substance or sour substance, particularly a drug containing a large amount of curcumin, and in this application invention, the large amount refers to a dose of curcumin of 100 mg / day or more, In the case of an external preparation, it means a concentration of 0.01% or more.
The drugs in the invention of this application are nutrients, digestive agents, muscular agents, anti-inflammatory agents, anti-cerebral infarction agents, anti-motor paralysis agents, anti-asthma agents, anti-visual acuity agents, antidepressants, anti-menopausal disorders Agent, anti-senile dementia agent, anti-Alzheimer agent, anti-dementia agent, stress gastritis preventive / therapeutic agent, infertility agent, bowel movement promoter, internal bleeding agent, diuretic, anticancer agent, dermatological agent, etc. .
Gastrointestinal agents include irritable colitis, ulcerative colitis, Crohn's disease, localized enteritis, anti-hepatitis, anti-inflammatory bowel, anti-functional enteropathy, anti It refers to functional cardiopathic agents, anti-functional liver dysfunction agents, anti-functional kidney dysfunction agents, anti-diarrheal agents, and dermatological agents are acne treatment agents, herpes simplex treatment agents , Simple herpes zoster treatment, shingles treatment, seborrheic eczema treatment, athlete's foot treatment, white fungus treatment, nail white fungus treatment, wart treatment, fish eye treatment, vitiligo treatment, baldness treatment, Alopecia areata treatment, dryness treatment, vulva eczema treatment, housewife eczema (progressive palmokeratoderma) treatment, skin beautification, atopic dermatitis treatment, dermatitis treatment, skin fungus Therapeutic action, wart treatment action, pigmentation treatment action, psoriasis vulgaris, xeroderma dermatosis, senile keratoma For 療作, skin damage treatment effect, hair growth promoting action, digestion fluid secretion promoting action, refers to perspiration promoting action, is intended to include cosmetic.
The cosmetics refer to cosmetics such as whitening, spots, wrinkles, hair growth, and hair growth.

The present invention relates to a drug containing a large amount of pungent substance, bitter substance or sour substance, particularly a drug containing a large amount of curcumin, in particular, isoflavone and / or isoflavone glycoside, and / or cholic acid, and A medicament comprising bile powder, bile extract, bile acid, cormorant or artificial coral, or simanol and / or simanol ester can be provided.
According to the invention of this application, prevention of disease, enhancement of natural healing ability, and promotion of recovery after disease can be achieved at the same time.
According to the invention of this application, there is an excellent effect that the immunity is increased, the stamina is increased, and the recovery of the stamina is promoted by keeping the body always in a normal state.
In particular, administration of isoflavones and / or isoflavone glycosides and / or cholic acid, and / or bile powder, bile extract, bile acid, goo or artificial goo, or simnol and / or simnol ester increases physical strength. In addition, it promotes recovery of physical strength and has an excellent effect as a drug.
The present invention has an excellent effect that an excellent drug can be provided by a synergistic action of a drug containing a large amount of pungent substance, bitter substance or sour substance, particularly a large amount of curcumin and isoflavone.
The drugs in the invention of this application are nutrients, digestive organs, strong muscle agents, anti-inflammatory agents, anti-cerebral infarction agents, anti-motor paralysis agents, anti-asthma agents, anti-visual loss agents, antidepressants, anti-menopausal agents Anti-senile dementia agent, anti-Alzheimer agent, anti-dementia agent, stress gastritis preventive / therapeutic agent, infertility agent, bowel movement accelerator, internal bleeding agent, diuretic, anticancer agent, dermatological agent and the like.
Gastrointestinal agents include irritable colitis, ulcerative colitis, Crohn's disease, localized enteritis, anti-hepatitis, anti-inflammatory bowel, anti-functional enteropathy, anti It is a functional heart disorder agent, anti-function liver disorder agent, anti-function kidney disorder agent, anti-diarrhea agent, and dermatological agents are acne (acne vulgaris) treatment, herpes (simple herpes) treatment , Simple herpes zoster treatment, shingles treatment, seborrheic eczema treatment, athlete's foot treatment, white fungus treatment, nail white fungus treatment, wart treatment, fish eye treatment, vitiligo treatment, baldness treatment, Alopecia areata treatment, dryness treatment, vulva eczema treatment, housewife eczema (progressive palmokeratoderma) treatment, skin beautification, atopic dermatitis treatment, dermatitis treatment, skin fungus Therapeutic action, wart treatment action, pigmentation treatment action, psoriasis vulgaris, xeroderma dermatosis, senile keratoma For 療作, skin damage treatment effect, hair growth promoting action, digestion fluid secretion promoting action, a perspiration promoting action, is intended to include cosmetic.
The cosmetics are cosmetics such as whitening, spots, wrinkles, hair growth, and hair growth.

  The invention of this application comprises isoflavones and / or isoflavone glycosides and / or cholic acid, and / or bile powder, bile extract, bile acid, gourd or artificial gourd, and / or simnol and / or simnol ester Is preferred.

  As isoflavones and isoflavone glycosides, soybean isoflavones and soybean isoflavone glycosides contained in soybean are particularly preferable.

  The daily dose of isoflavone and isoflavone glycoside is preferably 1 to 500 mg, more preferably 5 to 200 mg, and particularly preferably 10 to 100 mg.

トウガラシのカプサイシン、

コショウのピペリン、

ショウガのジンゲロン、

ショウガの［６］−ショーガオール、

ショウガの［６］−ジンゲロール

であることが好ましく、クルクミンがとくに好ましい。 The pungent substance, bitter substance or sour substance of the invention of this application is preferably a food, and is preferably a pungent substance.
The pungent substance is turmeric curcumin,

Capsicum capsicum,

Pepperine with pepper,

Ginger gingeron,

Ginger [6]-Shogaol,

[6] -gingerol of ginger

And curcumin is particularly preferred.

The bitter substance is preferably swell thiamarin, gentiopicrin, or loganin.
The sour substance is preferably citric acid or lactic acid.

The daily dose of the pungent substance, particularly curcumin, is preferably 100 to 1000 mg, more preferably 100 to 300 mg, and particularly preferably 150 to 250 mg. In the case of an external preparation, 0.01 to 1% is preferable, and 0.01 to 0.1% is particularly preferable.
In addition, the daily dose when combined with a Chinese medicine preparation or a Chinese medicine having a correcting effect such as Juzentaihoto is preferably 100 to 200 mg.

  The daily dose of cholic acid is preferably 1 to 1000 mg, more preferably 2 to 300 mg, and particularly preferably 10 to 100 mg.

また、シムノール硫酸エステルナトリウム塩はつぎの構造式で表される。

Simnole and / or Simnol ester is contained in the bile of salmon.
Simnol is represented by the following structural formula:

Simnol sulfate sodium salt is represented by the following structural formula.

  The daily dose of simnole and / or simnol ester is preferably 0.1 to 100 mg, more preferably 0.1 to 50 mg, and particularly preferably 0.3 to 10 mg.

Although the bile powder of this application invention is not specifically limited, For example, bile powders, such as a bear, a pig, a cow, etc. are especially preferable.
The daily amount of bile powder, bile extract, bile acid, gourd and artificial gourd is preferably 1 to 10,000 mg, more preferably 10 to 5000 mg, and particularly preferably 50 to 2000 mg.

  As other ingredients, pharmaceuticals in general are used, and vitamins, antibiotics, anticancer agents, heme iron, prune extract, and crude drugs are used.

Preferred crude drugs are those that have a correcting effect, such as those that activate the functions of organs, glands and blood vessels that are governed by autonomic nerves, and those that aid digestion.
More than ten kinds of herbal medicines that activate the functions of organs, glands, and blood vessels controlled by autonomic nerves are known. For example, there are carrots, but some active ingredients of these herbal medicines including carrots are already clear. Has been.
Therefore, it is preferable to contain these active ingredients. By further including these active ingredients, a function activation effect can be exhibited.
Such herbal medicines include carrots, carrots, ginseng, talisins, western ginseng, jade, birch jutsu, sanyaku, licorice. Especially preferred are Taisu, Koui, Yellow spirit, and Yotsugin.

  In addition, it is particularly preferable to include hawthorn, Shinkiku, life comb, malt (Bakuga), bud (Kokuga), chicken inner gold (Kainaikin), Aki (Agi), etc., which are herbal medicines that help digestion.

  In addition, it is preferable to include herbal medicines with antibacterial and antiviral effects, and as herbal medicines with antibacterial and antiviral effects, there are kakkon, kashuku, nikkei, tanjin, and cheng. (Chimpi), beetle (Yakumoso), Shisoha (Osoyo), Hou Ren (Ouren), ク リ (Bukryo), Itanone (Van Lancon), 蒲公英 (Hokoei), 茴香 (Fennel), senkyu, caterpillar, etc. are particularly preferred.

Another material used in the invention of this application is isoflavone and isoflavone glycoside.
The active ingredients for this purpose contained in soybeans are several isoflavone glycosides such as soybean in (Gaidin), glycitin (Glycitin), genistin (Gaistin) and the like, and their aglycones (Daizein), glycitein There are several isoflavones such as (Glycitein) and Genistein.
Soybean is a raw material for producing soybean oil, but the demand for soybean oil is large, and soybean meal, a by-product, is produced in large quantities at the same time. A part of soybean meal is used as a raw material for producing soybean protein as a raw material for food, but it is mainly used as fertilizer and feed, and its price is extremely low. Soybean isoflavone and soybean isoflavone glycosides can be produced with high purity and low cost from soybean meal that is close to industrial waste.

  The invention of this application preferably contains inosinic acid.

The invention of this application preferably contains an odd number of fatty acids.
As the odd fatty acid, tridecanoic acid, pentadecanoic acid, heptadecanoic acid, and nonadecanoic acid are preferable, and pentadecanoic acid and heptadecanoic acid are particularly preferable.
Moreover, it is preferable that this application invention contains docosahexaenoic acid.

The crude drug of the invention of this application may be used as it is, or an extracted one may be used.
In addition, the dosage form of the drug of the present invention is not particularly limited, but it is administered as a tablet, capsule, powder, solid, liquid or the like.
Moreover, when administering, it is although it does not specifically limit, It is preferable to administer twice a day.

Hereinafter, the present invention will be described in detail.
The purity of the soy isoflavone and soy isoflavone glycoside used was 40%.
Moreover, the purity of cholic acid used other than a pure product is 90%.

Powder curcumin 180mg
Simnole 1mg
Soy isoflavone 125mg
Lactose 800mg
Corn starch
Magnesium stearate 10mg
Total 2000mg
(1 bag 1g twice a day)
Similarly, powder was prepared using soy isoflavone glycosides instead of soy isoflavone.

Granule curcumin 180mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Lactose 1500mg
Corn starch appropriate amount Magnesium stearate 10mg
Total 2000mg
(1 bag 1g twice a day)
Similarly, granules were produced using soy isoflavone glycosides instead of soy isoflavones.

Tablet curcumin 180mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Crystalline cellulose appropriate amount lactose 140mg
Magnesium stearate 6mg
Talc 3mg
Total 1120mg
(1 tablet, 280 mg, 2 tablets, 2 times a day)
Similarly, tablets were made using soy isoflavone glycosides instead of soy isoflavones.

Tablet curcumin 150mg
Simnole 1mg
Soy isoflavone 250mg
Carrot powder 2000mg
Lactose 886mg
Crystalline cellulose appropriate amount Carboxymethylcellulose calcium 320mg
Hydroxypropylcellulose 558mg
Carplex 30mg
Magnesium stearate 55mg
Total 5600mg
(1 tablet, 280 mg, 5 tablets, 2 times a day)
Similarly, tablets were made using soy isoflavone glycosides instead of soy isoflavones.

Hard capsule curcumin 180mg
Simnole 1mg
Soy isoflavone 125mg
Lactose 218mg
Corn starch appropriate amount Magnesium stearate 6mg
Total 1150mg
(1 capsule / 4 capsules, 2 capsules once a day twice)
Similarly, hard capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Soft capsule curcumin 200mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Carrot extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)
Similarly, soft capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Drink curcumin 150mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Ginseng extract 10mg
Giant extract 10mg
Royal Jelly 100mg
Thiamine nitrate 10mg
Riboflavin sodium phosphate 5mg
Pyridoxine hydrochloride 10mg
Anhydrous caffeine 50mg
Ethanol 1.2mL
Ethyl paraoxybenzoate 4mg
Purified water
Total 50 mL bottle Similarly, a drink was prepared using soy isoflavone glycoside instead of soy isoflavone.

Vitamin preparation (hard capsule)
Curcumin 200mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Thiamine hydrochloride 25mg
Pyridoxine hydrochloride 10mg
Riboflavin 10mg
Cyanocobalamin 12mg
Nicotinamide 20mg
Calcium pantothenate 20mg
Ascorbic acid 60mg
L-cysteine 10m
Lactose 263mg
Magnesium stearate 6mg
Corn starch appropriate amount total 1150mg
(2 capsules, 2 times a day)
Similarly, hard capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Injection curcumin 180mg
Simnol sulfate sodium salt 1mg
Pure soy isoflavone 20mg
Glucose 500mg
Make pH 7 with 10% sodium hydroxide for pH adjustment, add distilled water for injection to make a total volume of 5 mL, sterilize after ampules are sealed.
Similarly, an injection was prepared using soy isoflavone glycoside instead of soy isoflavone.

Powder curcumin 180mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Lactose 2700mg
Corn starch appropriate amount light silicic acid anhydride 5mg
Magnesium stearate 10mg
Total 4000mg (1 packet 2g twice a day)
Similarly, powder was prepared using soy isoflavone instead of soy isoflavone glycoside.

Granule curcumin 150mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Lactose 2700mg
Corn starch appropriate amount crystalline cellulose 300mg
Light anhydrous silicic acid 5mg
Magnesium stearate 10mg
Total 4000mg (1 packet 2g twice a day)
Similarly, granules were produced using soy isoflavones instead of soy isoflavone glycosides.

Spherical granule curcumin 180mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Lactose 515mg
Corn starch 500mg
Crystalline cellulose 400mg
Total 2000mg (1 packet 1g twice a day)
Similarly, spherical granules were produced using soy isoflavone instead of soy isoflavone glycoside.

Tablet curcumin 180mg
Cholic acid 140mg
Soy isoflavone glycoside 280mg
Lactose 4000mg
Carboxymethylcellulose calcium 320mg
Hydroxypropylcellulose 74mg
Crystalline cellulose appropriate amount Carplex 30mg
Magnesium stearate 10mg
Total 5484mg (1 tablet 280mg once 5 tablets twice a day)
Similarly, tablets were produced using soy isoflavones instead of soy isoflavone glycosides.

Hard capsule curcumin 200mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Corn starch appropriate amount Magnesium stearate 9mg
Total 1153mg (1 capsule 4 capsules per day)
Similarly, hard capsules were produced using soy isoflavones instead of soy isoflavone glycosides.

Soft capsule curcumin 180mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Beeswax 55mg
Edible oil appropriate amount total 1200mg (4 capsules per day)
Similarly, soft capsules were produced using soy isoflavones instead of soy isoflavone glycosides.

Injection curcumin 170mg
Pure cholic acid 20mg
Pure soybean isoflavone glycoside 20mg
Glucose 1000mg
pH adjuster Sodium carbonate Add an appropriate amount of distilled water for injection to make a total volume of 5 ml.
Similarly, an injection was prepared using soy isoflavone instead of soy isoflavone glycoside.

Drink curcumin 180mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Ginseng extract 1500mg
Longan Extract 100mg
Garbage extract 300mg
Royal Jelly 150mg
Riboflavin sodium phosphate 10mg
Ethanol 1.2ml
Paraoxybenzoic acid 4mg
Purified water appropriate amount total 50ml
Similarly, a drink was prepared using soy isoflavone instead of soy isoflavone glycoside.

Granule curcumin 170mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Thiamine hydrochloride 10mg
Pyridoxine hydrochloride 100mg
Hydroxocobalamin hydrochloride 1.027mg
Tocopherol acetate 100mg
Lactose 2700mg
Crystalline cellulose 300mg
Light anhydrous silicic acid 5mg
Magnesium stearate 10mg
Corn starch appropriate amount total 4000mg (1 sachet 2g twice a day)
Similarly, granules were produced using soy isoflavones instead of soy isoflavone glycosides.

Capsule curcumin 180mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Vitamin A oil 4mg
Cholecalciferol 0.005mg
Tocopherol acetate 10mg
Vitamin C 600mg
Crystalline cellulose 250mg
Magnesium stearate 6mg
Corn starch appropriate amount total 1150mg
(1 capsule / 4 capsules, 2 capsules once a day twice)
Similarly, capsules were made using soy isoflavones instead of soy isoflavone glycosides.

Capsule curcumin 170mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Cephalexin 375mg
Corn starch appropriate amount Magnesium stearate 6mg
Total 855mg (No.2 capsules / 3)
Similarly, capsules were made using soy isoflavones instead of soy isoflavone glycosides.

Soft capsule curcumin 250mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Heptadecanoic acid 30mg
Inosinic acid 100mg
Carrot extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)
Similarly, soft capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Soft capsule curcumin 180mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Heptadecanoic acid 30mg
Inosinic acid 100mg
Beeswax 55mg
Edible oil appropriate amount total 1200mg (4 capsules per day)
Similarly, soft capsules were produced using soy isoflavones instead of soy isoflavone glycosides.

  Although no studies have been conducted on the effects of curcumin, zingerone, and shogaol on promoting adrenergic secretion, animal experiments using sputum showed a marked increase in blood glucose concentration, confirming the existence of adrenergic stimulating action. It was.

Powder curcumin 250mg
Cholic acid 60mg
Bile powder 100mg
Soybean isoflavone glycoside 125mg
Lactose 2700mg
Corn starch appropriate amount light silicic acid anhydride 5mg
Magnesium stearate 10mg
Total 4000mg (1 packet 2g twice a day)
Similarly, powder was prepared using soy isoflavone instead of soy isoflavone glycoside.

Granule curcumin 200mg
Cholic acid 60mg
Gooh powder 100mg
Soybean isoflavone glycoside 125mg
Lactose 2700mg
Corn starch 800mg
Crystalline cellulose 300mg
Light anhydrous silicic acid 5mg
Magnesium stearate 10mg
Total 4000mg
Similarly, granules were produced using soy isoflavones instead of soy isoflavone glycosides.

Spherical granule curcumin 190mg
Cholic acid 60mg
Bile powder 100mg
Soybean isoflavone glycoside 125mg
Lactose 515mg
Corn starch 500mg
Crystalline cellulose 400mg
Total 2000mg
Similarly, spherical granules were produced using soy isoflavone instead of soy isoflavone glycoside.

Tablets curcumin 250mg
Cholic acid 140mg
Gooh powder 100mg
Soy isoflavone glycoside 280mg
Lactose 4000mg
Carboxymethylcellulose calcium 320mg
Hydroxypropylcellulose 74mg
Crystalline cellulose appropriate amount Carplex 30mg
Magnesium stearate 10mg
Total 5484mg (1 tablet 280mg once 5 tablets twice a day)
Similarly, tablets were produced using soy isoflavones instead of soy isoflavone glycosides.

Hard capsule curcumin 180mg
Cholic acid 60mg
Bile powder 100mg
Soybean isoflavone glycoside 125mg
Corn starch appropriate amount Magnesium stearate 9mg
Total 1153mg (1 capsule 4 capsules per day)
Similarly, hard capsules were produced using soy isoflavones instead of soy isoflavone glycosides.

Soft capsule curcumin 200mg
Cholic acid 60mg
Gooh powder 100mg
Soybean isoflavone glycoside 125mg
Beeswax 55mg
Edible oil appropriate amount total 1200mg (4 capsules per day)
Similarly, soft capsules were produced using acetyl soybean isoflavone and soybean isoflavone instead of soybean isoflavone glycoside.

Soft capsule curcumin 190mg
Cholic acid 60mg
Gooh powder 100mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Carrot extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)
Similarly, soft capsules were produced using acetyl soybean isoflavone and soybean isoflavone glycoside in place of soybean isoflavone.

Soft capsule curcumin 190mg
Cholic acid 60mg
Bile powder 100mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Carrot extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)
Similarly, soft capsules were produced using acetyl soybean isoflavone and soybean isoflavone glycoside in place of soybean isoflavone.

Soft capsule curcumin 190mg
Cholic acid 60mg
Gooh powder 100mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Carrot extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)
Similarly, soft capsules were produced using acetyl soybean isoflavone and soybean isoflavone glycoside in place of soybean isoflavone.

Drink curcumin 190mg
Cholic acid 60mg
Bile powder 100mg
Soybean isoflavone glycoside 125mg
Ginseng extract 1500mg
Longan Extract 100mg
Garbage extract 300mg
Royal Jelly 150mg
Riboflavin sodium phosphate 10mg
Ethanol 1.2ml
Paraoxybenzoic acid 4mg
Purified water appropriate amount total 50ml
Similarly, a drink was prepared using soy isoflavone instead of soy isoflavone glycoside.

Granule curcumin 250mg
Cholic acid 60mg
Gooh powder 100mg
Soybean isoflavone glycoside 125mg
Thiamine hydrochloride 10mg
Pyridoxine hydrochloride 100mg
Hydroxocobalamin hydrochloride 1.027mg
Tocopherol acetate 100mg
Lactose 2700mg
Crystalline cellulose 300mg
Light anhydrous silicic acid 5mg
Magnesium stearate 10mg
Corn starch proper amount total 4000mg (1g 2g, 2 times a day)
Similarly, granules were produced using soy isoflavones instead of soy isoflavone glycosides.

Capsule curcumin 200mg
Cholic acid 60mg
Bile powder 100mg
Soybean isoflavone glycoside 125mg
Vitamin A oil 4mg
Cholecalciferol 0.005mg
Tocopherol acetate 10mg
Vitamin C 600mg
Crystalline cellulose 250mg
Magnesium stearate 6mg
Corn starch appropriate amount total 1150mg (1 capsule, 4 capsules per day)
Similarly, capsules were made using soy isoflavones instead of soy isoflavone glycosides.

Powder curcumin 180mg
Cholic acid 60mg
Bile powder 100mg
Soybean isoflavone glycoside 125mg
Lactose 2700mg
Corn starch appropriate amount light silicic acid anhydride 5mg
Magnesium stearate 10mg
Total 4000mg (1 packet 2g twice a day)
Similarly, powder was prepared using soy isoflavone instead of soy isoflavone glycoside.

Granule curcumin 100mg
Cholic acid 60mg
Gooh powder 100mg
Soybean isoflavone glycoside 125mg
Lactose 2700mg
Corn starch appropriate amount crystalline cellulose 300mg
Light anhydrous silicic acid 5mg
Magnesium stearate 10mg
Total 4000mg
Similarly, granules were produced using soy isoflavones instead of soy isoflavone glycosides.

Tablet curcumin 180mg
Cholic acid 140mg
Bile powder 100mg
Soy isoflavone glycoside 280mg
Lactose 4000mg
Carboxymethylcellulose calcium 320mg
Hydroxypropylcellulose 74mg
Crystalline cellulose appropriate amount Carplex 30mg
Magnesium stearate 10mg
Total 5484mg (1 tablet 280mg once 5 tablets twice a day)
Similarly, tablets were produced using soy isoflavones instead of soy isoflavone glycosides.

Hard capsule curcumin 150mg
Cholic acid 60mg
Gooh powder 100mg
Soybean isoflavone glycoside 125mg
Corn starch appropriate amount Magnesium stearate 9mg
Total 1153mg (1 capsule 4 capsules per day)
Similarly, hard capsules were produced using soy isoflavones instead of soy isoflavone glycosides.

Drink curcumin 180mg
Cholic acid 60mg
Bile powder 100mg
Soybean isoflavone glycoside 125mg
Ginseng extract 1500mg
Longan Extract 100mg
Garbage extract 300mg
Royal Jelly 150mg
Riboflavin sodium phosphate 10mg
Ethanol 1.2ml
Paraoxybenzoic acid 4mg
Purified water appropriate amount total 50ml
Similarly, a drink was prepared using soy isoflavone instead of soy isoflavone glycoside.

Soft capsule curcumin 190mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Carrot extract 80mg
Banglancon Extract 120mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)

Soft capsule curcumin 190mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Carrot extract 100mg
Ouren extract 80mg
Beeswax 55mg
Edible oil
Total 1200mg
Similarly, soft capsules were produced using soy isoflavones instead of soy isoflavone glycosides.

  Administration of the soft capsules of Examples 6 and 15 was effective as a drug.

Cholic acid 0.02%
Gooh powder 0.01
Soy isoflavone 0.03
Curcumin 0.02
Glycerin 2.8
Oleyl alcohol 0.16
Ethanol 10.0
Sodium benzoate 0.9
Purified water Suitable amount Total amount 100.00 (wt%)
Perfume

Simnol sulfate Na 0.001%
Bile powder 0.02
Soy isoflavone 0.03
Curcumin 0.02
Carrot saponin 0.002
Glycerin 2.8
Oleyl alcohol 0.16
Ethanol 15.0
Sodium benzoate 0.9
Purified water Suitable amount Total amount 100.00 (wt%)
Perfume

Simnol sulfate Na 0.001%
Artificial goose 0.05
Soy isoflavone 0.03
Curcumin 0.02
1,3-butylene glycol 6.0
Glycerin 4.0
Oleyl alcohol 0.1
POE (20) sorbitan monolaurate 0.5
POE (15) lauryl alcohol ether 0.5
Ethanol 10.0
Sodium benzoate 0.9
Purified water Suitable amount Total amount 100.00 (wt%)
Perfume

Simnol sulfate Na 0.001%
Bile extract 0.02
Soy isoflavone 0.03
Curcumin 0.02
Carrot saponin 0.002
Glycerin 2.8
Oleyl alcohol 0.16
Ethanol 15.0
Sodium benzoate 0.9
Purified water Suitable amount Total amount 100.00 (wt%)
Perfume

Simnol sulfate Na 0.001%
Bile acid 0.05
Soy isoflavone 0.03
Curcumin 0.02
1,3-butylene glycol 6.0
Glycerin 4.0
Oleyl alcohol 0.1
POE (20) sorbitan monolaurate 0.5
POE (15) lauryl alcohol ether 0.5
Ethanol 10.0
Sodium benzoate 0.9
Purified water Suitable amount Total amount 100.00 (wt%)
Perfume

  The present invention relates to a drug containing a large amount of pungent substance, bitter substance or sour substance, in particular, a drug containing a large amount of curcumin, isoflavone and / or isoflavone glycoside, and / or cholic acid, and / or The present invention relates to a drug containing bile powder, bile extract, bile acid, cormorant or artificial coral, and / or simanol and / or simanol ester.

Claims (6)

A drug containing a large amount of pungent substance, bitter substance or sour substance. The medicine according to claim 1, wherein the pungent substance, the bitter substance or the sour substance is a pungent substance. The medicine according to claim 1 or 2, wherein the pungent substance is curcumin. Claims comprising isoflavones and / or isoflavone glycosides, and / or cholic acid, and / or bile powder, bile extract, bile acid, gourd or artificial gourd, and / or simnol and / or simnol ester Item 4. The drug according to any one of Items 1 to 3. Drugs are nutrients, digestive agents, strong muscle agents, anti-inflammatory agents, anti-cerebral infarction agents, anti-motor paralysis agents, anti-asthma agents, anti-visual loss agents, antidepressants, anti-menopausal agents, anti-senile dementia An anti-Alzheimer agent, an anti-dementia agent, a stress gastritis preventive / therapeutic agent, an infertility agent, a bowel movement promoting agent, an internal bleeding treatment agent, a diuretic, an anticancer agent or a dermatological agent The medicine in any one of 1-4. The drug according to claim 5, wherein the dermatological agent is a cosmetic.