JP2014221822A - Digestive organ insufficient therapeutic agent for animals - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition for improving digestive organ insufficiency in animals.SOLUTION: Provided is a digestive organ insufficient therapeutic agent for animals containing isoflavone and/or isoflavone glucoside, and curcumin, and cholic acid. By administering isoflavone, cholic acid or scymnol and a pungent substance, a bitter substance or a sour substance, particularly a pungent substance, a synergy thereof has an excellent efficacy against malnutrition and digestive organ insufficiency. Although curcumin from turmeric is preferable as a pungent substance herein, capsaicin from red pepper, piperine from pepper or zingerone from ginger, [6]-shogaol, or [6]-gingerol may be sufficient. Swertiamarin, loganin and the like are preferable as a bitter substance, and citric acid and lactic acid are preferable as a sour substance.

Description

    The present invention relates to a new therapeutic agent for digestive dysfunction for animals.

The fulfillment of the will in the brain, that is, the fulfillment of energy, is governed by the brain hormones serotonin and noradrenaline, and in response to this fulfillment, the voluntary muscles are secreted from adrenal bone marrow and neuromuscular chromaffin cells and adrenal medullary hormones Is activated by adrenaline.
Serotonin, noradrenaline, and adrenaline are called biological monoamines, and most monoamines that are secreted by oxidative degradation by the enzyme monoamine oxidase or reabsorbed into nerve tissue within a maximum of 3 hours lose their action. .
This is a clever human body mechanism to prevent fatigue because monoamines cause fatigue by acting for a long time.
By the way, Qi refers to all functions of the human body, but the functions are roughly divided into two types. One of them is the function of each organ, hormone secretion, blood vessels, etc. The other is the function of brain thinking and voluntary muscles that move by commands issued by brain thinking.
It has been pointed out early that the qi expressed by reassurance and morality in Chinese medicine only refers to the function of the autonomic innervation of the former. The command to show how much of these functions is issued from the medulla at the bottom of the brain. Considering that the function of all autonomic innervation is activated rather than activating only a specific organ or organ with an adiabatic agent, the point of action of the adiabatic agent is not the organ or organ but the command source It is considered to be a medulla In other words, the action of the aspirating drug is to promote the transmission of commands from the medulla and the enhancement of its transmission. We have found that ablative drugs cause the blood in the body to be unevenly distributed in organs, etc., and this is also one of the important actions of medulla oblongata, which acts for vasoconstriction and dilation, leading to the autonomic nervous system It is achieved by expanding blood vessels and constricting blood vessels toward the brain and brain-regulated organs, and aims to send more nutrients to the necessary parts as a side effect of the aerobic agent.

JP 2002-255823 A JP-A-10-114649 Japanese Patent Application No. 2002-42639 (Japanese Patent No. 4609875) JP 2002-204672 A JP 2002-205998 A JP 2002-255823 A JP 2002-253169 A JP 2000-103718 A Japanese National Patent Publication No. 11-500725 Japanese Patent Application No. 2002-42639 (Japanese Patent Laid-Open No. 2003-245054) JP 2002-205998 A JP-A-10-114649

Various symptoms occur with age.
The cause of these disorders is due to insufficient transmission of brain commands to the local area, and is a trouble that occurs due to a blood circulation disorder.

  The object of the present invention is to treat malnutrition and digestive failure caused by such troubles.

  The present invention relates to A. Cholic acid, B.I. Soybean isoflavone or soybean isoflavone glycoside, C.I. The present invention relates to a therapeutic agent for digestive tract insufficiency for animals, comprising curcumin components A, B and C.

    The invention of this application is a faster treatment for malnutrition, digestive failure by administering isoflavones, cholic acid or simnol, and pungent substances, bitter substances or sour substances, in particular by synergy of pungent substances, There is an excellent effect that a nutritional agent that can be prevented and a therapeutic agent for digestive system failure can be provided.

The invention of this application is only required to contain a pungent substance, a bitter substance or a sour substance, but preferably contains isoflavones and isoflavone glycosides, and the isoflavones and isoflavone glycosides are soybeans contained in soybeans. Isoflavones and soy isoflavone glycosides are particularly preferred.
Moreover, when using isoflavone and an isoflavone glycoside, it is preferable to add cholic acid.

  The daily dose of isoflavone and isoflavone glycoside is preferably 1 to 500 mg, more preferably 5 to 200 mg, and particularly preferably 10 to 100 mg.

トウガラシのカプサイシン、

コショウのピペリン、

ショウガのジンゲロン、

ショウガの［６］−ショーガオール、

ショウガの［６］−ジンゲロール

であることが好ましく、クルクミンがとくに好ましい。
苦味物質は、スウェルチアマリン、ゲンチオピクリン、ロガニンが好ましい。
また、酸味物質は、クエン酸、乳酸が好ましい。 The pungent substance, bitter substance or sour substance of the present invention is preferably a pungent substance.
The pungent substance is turmeric curcumin,

Capsicum capsicum,

Pepperine with pepper,

Ginger gingeron,

Ginger [6]-Shogaol,

[6] -gingerol of ginger

And curcumin is particularly preferred.
The bitter substance is preferably swell thiamarin, gentiopicrin, or loganin.
The sour substance is preferably citric acid or lactic acid.

The daily dose of the pungent substance is preferably 1 to 1000 mg, more preferably 5 to 300 mg, and particularly preferably 10 to 70 mg.
The daily dose of these single uses is preferably 100 to 800 mg, particularly preferably 300 to 500 mg.
In addition, the daily dose when used in combination with a Chinese medicine preparation or Chinese medicine having a correcting effect such as Juzentaihoto is preferably 100 to 200 mg.

  The daily dose of cholic acid is preferably 1 to 1000 mg, more preferably 2 to 300 mg, and particularly preferably 10 to 100 mg.

  The daily dose of simnole and / or simnol ester is preferably 0.1 to 100 mg, more preferably 0.1 to 50 mg, and particularly preferably 0.3 to 10 mg.

As other ingredients, pharmaceuticals in general are used, and vitamins, antibiotics, anticancer agents, heme iron, prune extract, and crude drugs are used.
Preferred crude drugs are those that have a correcting effect, such as those that activate the functions of organs, glands and blood vessels that are governed by autonomic nerves, and those that aid digestion.

More than ten kinds of herbal medicines that activate the functions of organs, glands, and blood vessels controlled by autonomic nerves are known. For example, there are carrots, but some active ingredients of these herbal medicines including carrots are already clear. Has been.
Therefore, it is preferable to add these active ingredients. By further adding these active ingredients, the human body function activating effect can be exhibited.
Such herbal medicines include carrots, carrots, ginseng, talisins, western ginseng, jade, birch jutsu, sanyaku, licorice. Especially preferred are Taisu, Koui, Yellow spirit, and Yotsugin.

  In addition, it is particularly preferable to add hawthorn, shinki (kurin), life comb, malt (bakuga), cereal (kokuga), chicken inner gold (keinaikin), ahi (agi), etc., which are herbal medicines that help digestion.

また、シムノール硫酸エステルナトリウム塩はつぎの構造式で表される。

Simnole and / or Simnol ester is contained in the bile of salmon.
Simnol is represented by the following structural formula:

Simnol sulfate sodium salt is represented by the following structural formula.

Another material used in the invention of this application is isoflavone and isoflavone glycoside.
The active ingredients for this purpose contained in soybeans are several isoflavone glycosides such as soybean in (Gaidin), glycitin (Glycitin), genistin (Gaistin) and the like, and their aglycones (Daizein), glycitein There are several isoflavones such as (Glycitein) and Genistein.
Soybean is a raw material for producing soybean oil, but the demand for soybean oil is large, and soybean meal, a by-product, is produced in large quantities at the same time. A part of soybean meal is used as a raw material for producing soybean protein as a raw material for food, but it is mainly used as fertilizer and feed, and its price is extremely low. Soybean isoflavone and soybean isoflavone glycosides can be produced with high purity and low cost from soybean meal that is close to industrial waste.

  In the invention of this application, inosinic acid is preferably added.

The invention of this application preferably adds odd fatty acids.
As the odd fatty acid, tridecanoic acid, pentadecanoic acid, heptadecanoic acid, and nonadecanoic acid are preferable, and pentadecanoic acid and heptadecanoic acid are particularly preferable.

Although it does not specifically limit as a dosage form which administers the nutrient of this application invention and a digestive tract insufficiency agent, It administers as an internal medicine, a suppository, an injection, etc., such as a tablet, a powder agent, a solid agent, and a liquid agent.
In addition, excipients such as lactose and starch, vegetable oils, and others are used.

Hereinafter, the present invention will be described in detail.
The purity of the soy isoflavone and soy isoflavone glycoside used was 40%.
Moreover, the purity of cholic acid used other than a pure product is 90%.

Example 1
Powder
Curcumin 30mg
Simnole 1mg
Soy isoflavone 125mg
Lactose 800mg
Corn starch
Magnesium stearate 10mg
Total 2000mg
Similarly, powder was prepared using soy isoflavone glycosides instead of soy isoflavone.

Example 2
Granule curcumin 30mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Lactose 1500mg
Corn starch appropriate amount Magnesium stearate 10mg
Total 2000mg
Similarly, granules were produced using soy isoflavone glycosides instead of soy isoflavones.

Example 3
Tablet curcumin 30mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Crystalline cellulose appropriate amount lactose 140mg
Magnesium stearate 6mg
Talc 3mg
Total 1120mg
Similarly, tablets were made using soy isoflavone glycosides instead of soy isoflavones.

Example 4
Tablet curcumin 25mg
Simnole 1mg
Soy isoflavone 250mg
Carrot powder 2000mg
Lactose 886mg
Crystalline cellulose appropriate amount Carboxymethylcellulose calcium 320mg
Hydroxypropylcellulose 558mg
Carplex 30mg
Magnesium stearate 55mg
Total 5600mg
Similarly, tablets were made using soy isoflavone glycosides instead of soy isoflavones.

Example 5
Hard capsule curcumin 30mg
Simnole 1mg
Soy isoflavone 125mg
Lactose 218mg
Corn starch appropriate amount Magnesium stearate 6mg
Total 1150mg
Similarly, hard capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Example 6
Soft capsule curcumin 25mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Carrot extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
Similarly, soft capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Example 7
Drink curcumin 30mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Ginseng extract 10mg
Giant extract 10mg
Royal Jelly 100mg
Thiamine nitrate 10mg
Riboflavin sodium phosphate 5mg
Pyridoxine hydrochloride 10mg
Anhydrous caffeine 50mg
Ethanol 1.2L
Ethyl paraoxybenzoate 4mg
Purified water
Total 50 mL bottle Similarly, a drink was prepared using soy isoflavone glycoside instead of soy isoflavone.

Example 8
Vitamin preparation (hard capsule)
Curcumin 25mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Thiamine hydrochloride 25mg
Pyridoxine hydrochloride 10mg
Riboflavin 10mg
Cyanocobalamin 12μg
Nicotinamide 20mg
Calcium pantothenate 20mg
Ascorbic acid 60mg
L-cysteine 10m
Lactose 263mg
Magnesium stearate 6mg
Corn starch appropriate amount total 1150mg
Similarly, hard capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Example 9
Injection curcumin 30mg
Simnol sulfate sodium salt 1mg
Pure soy isoflavone 20mg
Glucose 500mg
Make pH 7 with 10% sodium hydroxide for pH adjustment, add distilled water for injection to make a total volume of 5 mL, sterilize after ampules are sealed.
Similarly, an injection was prepared using soy isoflavone glycoside instead of soy isoflavone.

Example 10
Powder curcumin 30mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Lactose 2700mg
Corn starch appropriate amount light silicic acid anhydride 5mg
Magnesium stearate 10mg
Total 4000mg (1 packet 2g twice a day)
Similarly, powder was prepared using soy isoflavone instead of soy isoflavone glycoside.

Example 11
Granule curcumin 25mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Lactose 2700mg
Corn starch appropriate amount crystalline cellulose 300mg
Light anhydrous silicic acid 5mg
Magnesium stearate 10mg
Total 4000mg
Similarly, granules were produced using soy isoflavones instead of soy isoflavone glycosides.

Example 12
Spherical granule curcumin 30mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Lactose 515mg
Corn starch 500mg
Crystalline cellulose 400mg
Total 2000mg
Similarly, spherical granules were produced using soy isoflavone instead of soy isoflavone glycoside.

Example 13
Tablet curcumin 30mg
Cholic acid 140mg
Soy isoflavone glycoside 280mg
Lactose 4000mg
Carboxymethylcellulose calcium 320mg
Hydroxypropylcellulose 74mg
Crystalline cellulose appropriate amount Carplex 30mg
Magnesium stearate 10mg
Total 5484mg (1 tablet 280mg once 5 tablets twice a day)
Similarly, tablets were produced using soy isoflavones instead of soy isoflavone glycosides.

Example 14
Hard capsule curcumin 25mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Corn starch appropriate amount Magnesium stearate 9mg
Total 1153mg (1 capsule 4 capsules per day)
Similarly, hard capsules were produced using soy isoflavones instead of soy isoflavone glycosides.

Example 15
Soft capsule curcumin 30mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Beeswax 55mg
Edible oil appropriate amount total 1200mg (4 capsules per day)
Similarly, soft capsules were produced using soy isoflavones instead of soy isoflavone glycosides.

Example 16
Injection curcumin 25mg
Pure cholic acid 20mg
Pure soybean isoflavone glycoside 20mg
Glucose 1000mg
pH adjuster Sodium carbonate Add an appropriate amount of distilled water for injection to make a total volume of 5 ml.
Similarly, an injection was prepared using soy isoflavone instead of soy isoflavone glycoside.

Example 17
Drink curcumin 30mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Ginseng extract 1500mg
Longan Extract 100mg
Garbage extract 300mg
Royal Jelly 150mg
Riboflavin sodium phosphate 10mg
Ethanol 1.2ml
Paraoxybenzoic acid 4mg
Purified water appropriate amount total 50ml
Similarly, a drink was prepared using soy isoflavone instead of soy isoflavone glycoside.

Example 18
Granule curcumin 25mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Thiamine hydrochloride 10mg
Pyridoxine hydrochloride 100mg
Hydroxocobalamin hydrochloride 1.027mg
Tocopherol acetate 100mg
Lactose 2700mg
Crystalline cellulose 300mg
Light anhydrous silicic acid 5mg
Magnesium stearate 10mg
Corn starch proper amount total 4000mg
Similarly, granules were produced using soy isoflavones instead of soy isoflavone glycosides.

Example 19
Capsule curcumin 30mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Vitamin A oil 4mg
Cholecalciferol 0.005mg
Tocopherol acetate 10mg
Vitamin C 600mg
Crystalline cellulose 250mg
Magnesium stearate 6mg
Corn starch appropriate amount total 1150mg (1 capsule)
Similarly, capsules were made using soy isoflavones instead of soy isoflavone glycosides.

Example 20
Capsule curcumin 25mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Cephalexin 375mg
Corn starch appropriate amount Magnesium stearate 6mg
Total 855mg (No.2 capsules / 3)
Similarly, capsules were made using soy isoflavones instead of soy isoflavone glycosides.

Example 21
Soft capsule curcumin 25mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Heptadecanoic acid 30mg
Inosinic acid 100mg
Carrot extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
Similarly, soft capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Example 22
Soft capsule curcumin 30mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Heptadecanoic acid 30mg
Inosinic acid 100mg
Beeswax 55mg
Edible oil appropriate amount total 1200mg (4 capsules per day)
Similarly, soft capsules were produced using soy isoflavones instead of soy isoflavone glycosides.

  Although no studies have been conducted on the effects of curcumin, zingerone, and shogaol on promoting adrenergic secretion, animal experiments using sputum showed a marked increase in blood glucose concentration, confirming the existence of adrenergic stimulating action. It was.

The soft capsule of Example 6 was taken once a day. As a result, the following effects were observed.
A 74-year-old woman was strengthened by taking it for 16 weeks. It was improved by taking it for 72 weeks by a 72-year-old man with weakness and chronic fatigue. Chronic fatigue and loss of energy improved after a 48-year-old man took for 2 weeks. A 74-year-old woman with a loss of appetite, who was overwhelmed and suffered from chronic fatigue and unwillingness, improved after taking it for 6 weeks. A 54-year-old woman with chronic fatigue syndrome improved after taking it for 7 weeks. A 43-year-old woman with paroxysmal positional change dizziness took 6 weeks to improve. A 50-year-old man complaining of dullness and lethargy improved after taking it for 6 weeks. A 36-year-old woman who complained of lethargy and lack of physical strength improved after taking it for 12 weeks.

  The present invention relates to a new therapeutic agent for digestive dysfunction.

Claims (5)

A. Cholic acid Soybean isoflavone or soybean isoflavone glycoside C.I. A therapeutic agent for digestive dysfunction for animals comprising A, B and C components of curcumin. A therapeutic agent for digestive tract failure for animals according to claim 1, wherein a vitamin preparation is added. Carrot, Carrot, Ginseng, Tai-jinjin, Western ginseng, Yellow ginseng, Japanese white birch, Sanyaku, Licorice, Licorice, Ganoderma, Kosei, Yotsuin, Hawthorn, Shinkiku, Life Kushi, Malt (Bakuga), Grain (Kokuga), Chicken inner gold (Kainaikin), Aki (Agi) The therapeutic agent for digestive tract failure for animals according to claim 1 or 2, wherein at least one of the above is added. Inosinic acid is added, The digestive tract insufficiency agent for animals in any one of Claims 1-3 characterized by the above-mentioned. Heptadecanoic acid is added, The digestive tract insufficiency therapeutic agent for animals in any one of Claims 1-4 characterized by the above-mentioned.