JP2005289817A - Anticancer agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain an anticancer agent containing cholic acid and/or scymnol. <P>SOLUTION: The present invention relates to the anticancer agent containing cholic acid and/or scymnol and/or a scymnol ester. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  This invention relates to a new anticancer agent.

Cancer accounts for a large percentage of current mortality.
There are many drugs for cancer, but most of them act directly on cancer cells to destroy them or prevent their growth.

  The invention of this application is to provide an anticancer agent, and aims to suppress cancer by enhancing immunity and making the body healthy.

  The present invention relates to an anticancer agent characterized by containing cholic acid and / or simanol and / or simanol ester.

The present invention relates to an anticancer agent containing cholic acid and / or simnole, and can provide an anticancer agent having an excellent effect.
According to this invention, it is possible to simultaneously achieve prevention of cancer, enhancement of natural healing ability, and promotion of recovery after illness.
The object of the present invention is to prevent cancer by always keeping the body in a normal state, and has an excellent effect of increasing the natural healing power against cancer and promoting the recovery of physical strength.
In particular, it has been found that cholic acid or simnol and / or simnol ester, curcumin, isoflavone and / or isoflavone glycoside improves cancer symptoms and has an excellent anticancer activity.

The invention of this application preferably contains a pungent substance, a bitter substance or a sour substance, but preferably contains isoflavones and isoflavone glycosides, and the isoflavones and isoflavone glycosides are contained in soybeans. Soy isoflavones and soy isoflavone glycosides are particularly preferred.
Moreover, when using isoflavone and an isoflavone glycoside, it is preferable to add cholic acid.

  The daily dose of isoflavone and isoflavone glycoside is preferably 1 to 500 mg, more preferably 5 to 200 mg, and particularly preferably 10 to 100 mg.

トウガラシのカプサイシン、

コショウのピペリン、

ショウガのジンゲロン、

ショウガの［６］−ショーガオール、

ショウガの［６］−ジンゲロール

であることが好ましく、クルクミンがとくに好ましい。
苦味物質は、スウェルチアマリン、ゲンチオピクリン、ロガニンが好ましい。
また、酸味物質は、クエン酸、乳酸が好ましい。 The pungent substance, bitter substance or sour substance of the present invention is preferably a pungent substance.
The pungent substance is turmeric curcumin,

Capsicum capsicum,

Pepperine with pepper,

Ginger gingeron,

Ginger [6]-Shogaol,

[6] -gingerol of ginger

And curcumin is particularly preferred.
The bitter substance is preferably swell thiamarin, gentiopicrin, or loganin.
The sour substance is preferably citric acid or lactic acid.

  The daily dose of the pungent substance is preferably 1 to 1000 mg, more preferably 5 to 300 mg, and particularly preferably 10 to 70 mg.

The cholic acid may be cholic acid itself, but may also be bile powder, bile extract, bile acid, gourd, artificial gourd and the like. These may be used alone or in combination.
The daily dose of cholic acid is preferably 1 to 1000 mg, more preferably 2 to 300 mg, and particularly preferably 10 to 100 mg.
The daily dose of simnole and / or simnol ester is preferably 0.1 to 100 mg, more preferably 0.1 to 50 mg, and particularly preferably 0.3 to 10 mg.

  As other ingredients, pharmaceuticals in general are used, and vitamins, antibiotics, anticancer agents, heme iron, prune extract, and crude drugs are used.

Preferred crude drugs are those that have a correcting effect, such as those that activate the functions of organs, glands and blood vessels that are governed by autonomic nerves, and those that aid digestion.
More than ten kinds of herbal medicines that activate the functions of organs, glands, and blood vessels controlled by autonomic nerves are known. For example, there are carrots, but some active ingredients of these herbal medicines including carrots are already clear. Has been.
Therefore, it is preferable to add these active ingredients. By further adding these active ingredients, a function activation effect can be exhibited.
Such herbal medicines include carrots, carrots, ginseng, talisins, western ginseng, jade, birch jutsu, sanyaku, licorice. Especially preferred are Taisu, Koui, Yellow spirit, and Yotsugin.

  In addition, it is particularly preferable to add hawthorn, shinki (kurin), life comb, malt (bakuga), cereal (kokuga), chicken inner gold (keinaikin), ahi (agi), etc., which are herbal medicines that aid digestion.

In addition, it is preferable to add herbal medicines with antibacterial and antiviral effects, and as herbal medicines with antibacterial and antiviral effects, there are kakkon, katsushi, nikkei, tanjin, and cinnamon. (Chimpi), beetle (Yakumoso), Shisoyo (Shisoyou), Huangren (Ouren), 茯苓 (Bukryo), Panang (Banlankong), Koei (Hokoei), 茴香 (Fennel), senkyu, and caterpillar are particularly preferred.
The daily dose of these single uses is preferably 100 to 800 mg, particularly preferably 300 to 500 mg.
In addition, the daily dose when used in combination with a Chinese medicine preparation or Chinese medicine having a correcting effect such as Juzentaihoto is preferably 100 to 200 mg.
Herbal medicine means not only the herbal medicine itself, but also extracts, extracts, main components, and the like.
For example, in the case of ginseng, it refers to ginseng extract, ginseng saponin, ginsenoside Rg group, ginsenoside Rbc group and the like.
In the case of licorice, it means licorice extract, licorice powder, licorice saponin, glycyrrhetinic acid, glycyrrhizic acid and the like.
In the case of jaundice, it means jaundice extract, jaundice powder, jaundice saponin, astragalside and the like.

また、シムノール硫酸エステルナトリウム塩はつぎの構造式で表される。

Simnole and / or Simnol ester is contained in the bile of salmon.
Simnol is represented by the following structural formula:

Simnol sulfate sodium salt is represented by the following structural formula.

Another material used in the invention of this application is isoflavone and isoflavone glycoside.
The active ingredients for this purpose contained in soybeans are several isoflavone glycosides such as soybean in (Gaidin), glycitin (Glycitin), genistin (Gaistin) and the like, and their aglycones (Daizein), glycitein There are several isoflavones such as (Glycitein) and Genistein.
Soybean is a raw material for producing soybean oil, but the demand for soybean oil is large, and soybean meal, a by-product, is produced in large quantities at the same time. A part of soybean meal is used as a raw material for producing soybean protein as a raw material for food, but it is mainly used as fertilizer and feed, and its price is extremely low. Soybean isoflavone and soybean isoflavone glycosides can be produced with high purity and low cost from soybean meal that is close to industrial waste.

  The invention of this application preferably adds inosinic acid.

The invention of this application preferably adds odd fatty acids.
As the odd fatty acid, tridecanoic acid, pentadecanoic acid, heptadecanoic acid, and nonadecanoic acid are preferable, and pentadecanoic acid and heptadecanoic acid are particularly preferable.
In the invention of this application, it is preferable to add docosahexaenoic acid.

Although it does not specifically limit as a dosage form which administers the anticancer agent of this application invention, It administers as an internal medicine, an injection, a suppository, etc., such as a tablet, a capsule, a powder agent, a solid agent, and a liquid agent.
Moreover, when administering, it is although it does not specifically limit, It is preferable to administer twice a day.

Hereinafter, the present invention will be described in detail.
The purity of the soy isoflavone and soy isoflavone glycoside used was 40%.
Moreover, the purity of cholic acid used other than a pure product is 90%.

Powder curcumin 45mg
Simnole 1mg
Soy isoflavone 125mg
Lactose 800mg
Corn starch appropriate amount Magnesium stearate 10mg
Total 2000mg
(1 bag 1g twice a day)
Similarly, powder was prepared using soy isoflavone glycosides instead of soy isoflavone.

Granule curcumin 45mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Lactose 1500mg
Corn starch
Magnesium stearate 10mg
Total 2000mg
(1 bag 1g twice a day)
Similarly, granules were produced using soy isoflavone glycosides instead of soy isoflavones.

Tablet curcumin 30mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Crystalline cellulose
Lactose 140mg
Magnesium stearate 6mg
Talc 3mg
Total 1120mg
(1 tablet, 280 mg, 2 tablets, 2 times a day)
Similarly, tablets were made using soy isoflavone glycosides instead of soy isoflavones.

Tablet curcumin 45mg
Simnole 1mg
Soy isoflavone 250mg
Carrot powder 2000mg
Lactose 886mg
Crystalline cellulose appropriate amount Carboxymethylcellulose calcium 320mg
Hydroxypropylcellulose 558mg
Carplex 30mg
Magnesium stearate 55mg
Total 5600mg
(1 tablet, 280 mg, 5 tablets, 2 times a day)
Similarly, tablets were made using soy isoflavone glycosides instead of soy isoflavones.

Hard capsule curcumin 45mg
Simnole 1mg
Soy isoflavone 125mg
Lactose 218mg
Corn starch
Magnesium stearate 6mg
Total 1150mg
(4 capsules for 1 day, 2 capsules, 2 times a day)
Similarly, hard capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Soft capsule curcumin 45mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Carrot extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)
Similarly, soft capsules were produced using acetyl soybean isoflavone and soybean isoflavone glycoside in place of soybean isoflavone.

Drink curcumin 45mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Ginseng extract 10mg
Giant extract 10mg
Royal Jelly 100mg
Thiamine nitrate 10mg
Riboflavin sodium phosphate 5mg
Pyridoxine hydrochloride 10mg
Anhydrous caffeine 50mg
Ethanol 1.2mL
Ethyl paraoxybenzoate 4mg
Purified water
Total 50mL / bottle
Similarly, a drink was prepared using soy isoflavone glycoside instead of soy isoflavone.

Vitamin preparation (hard capsule)
Curcumin 45mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Thiamine hydrochloride 25mg
Pyridoxine hydrochloride 10mg
Riboflavin 10mg
Cyanocobalamin 12μg
Nicotinamide 20mg
Calcium pantothenate 20mg
Ascorbic acid 60mg
L-cysteine 10m
Lactose 263mg
Magnesium stearate 6mg
Corn starch
Total 1150mg
(2 capsules, 2 times a day)
Similarly, hard capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Powder curcumin 45mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Lactose 2700mg
Corn starch appropriate amount light silicic acid anhydride 5mg
Magnesium stearate 10mg
Total 4000mg (1 packet 2g twice a day)
Similarly, powder was prepared using soy isoflavone instead of soy isoflavone glycoside.

Granule curcumin 45mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Lactose 2700mg
Corn starch 800mg
Crystalline cellulose 300mg
Light anhydrous silicic acid 5mg
Magnesium stearate 10mg
Total 4000mg
Similarly, granules were produced using soy isoflavones instead of soy isoflavone glycosides.

Spherical granule curcumin 45mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Lactose 515mg
Corn starch 500mg
Crystalline cellulose 400mg
Total 2000mg
Similarly, spherical granules were produced using soy isoflavone instead of soy isoflavone glycoside.

Tablet curcumin 45mg
Cholic acid 140mg
Soy isoflavone glycoside 280mg
Lactose 4000mg
Carboxymethylcellulose calcium 320mg
Hydroxypropylcellulose 74mg
Crystalline cellulose appropriate amount Carplex 30mg
Magnesium stearate 10mg
Total 5484mg (1 tablet 280mg once 5 tablets twice a day)
Similarly, tablets were produced using soy isoflavones instead of soy isoflavone glycosides.

Hard capsule curcumin 30mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Corn starch appropriate amount Magnesium stearate 9mg
Total 1153mg (1 capsule 4 capsules per day)
Similarly, hard capsules were produced using soy isoflavones instead of soy isoflavone glycosides.

Soft capsule curcumin 45mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Beeswax 55mg
Edible oil appropriate amount total 1200mg (4 capsules per day)
Similarly, soft capsules were produced using acetyl soybean isoflavone and soybean isoflavone instead of soybean isoflavone glycoside.

Soft capsule curcumin 45mg
Cholic acid 60mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Carrot extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)
Similarly, soft capsules were produced using acetyl soybean isoflavone and soybean isoflavone glycoside in place of soybean isoflavone.

Soft capsule curcumin 45mg
Cholic acid 60mg
Bile powder 100mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Carrot extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)
Similarly, soft capsules were produced using acetyl soybean isoflavone and soybean isoflavone glycoside in place of soybean isoflavone.

Soft capsule curcumin 45mg
Cholic acid 60mg
Gooh powder 100mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Carrot extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)
Similarly, soft capsules were produced using acetyl soybean isoflavone and soybean isoflavone glycoside in place of soybean isoflavone.

Drink curcumin 45mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Ginseng extract 1500mg
Longan Extract 100mg
Garbage extract 300mg
Royal Jelly 150mg
Riboflavin sodium phosphate 10mg
Ethanol 1.2ml
Paraoxybenzoic acid 4mg
Purified water appropriate amount total 50ml
Similarly, a drink was prepared using soy isoflavone instead of soy isoflavone glycoside.

Granule curcumin 45mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Thiamine hydrochloride 10mg
Pyridoxine hydrochloride 100mg
Hydroxocobalamin hydrochloride 1.027mg
Tocopherol acetate 100mg
Lactose 2700mg
Crystalline cellulose 300mg
Light anhydrous silicic acid 5mg
Magnesium stearate 10mg
Corn starch proper amount total 4000mg (1g 2g, 2 times a day)
Similarly, granules were produced using soy isoflavones instead of soy isoflavone glycosides.

Capsule curcumin 45mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Vitamin A oil 4mg
Cholecalciferol 0.005mg
Tocopherol acetate 10mg
Vitamin C 600mg
Crystalline cellulose 250mg
Magnesium stearate 6mg
Corn starch appropriate amount total 1150mg (1 capsule, 4 capsules per day)
Similarly, capsules were made using soy isoflavones instead of soy isoflavone glycosides.

Powder
Curcumin 30mg
Simnole 1mg
Soy isoflavone 125mg
Lactose 800mg
Corn starch
Magnesium stearate 10mg
Total 2000mg
Similarly, powder was prepared using soy isoflavone glycosides instead of soy isoflavone.

Granule curcumin 30mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Lactose 1500mg
Corn starch appropriate amount Magnesium stearate 10mg
Total 2000mg
Similarly, granules were produced using soy isoflavone glycosides instead of soy isoflavones.

Tablet curcumin 25mg
Simnole 1mg
Soy isoflavone 250mg
Carrot powder 2000mg
Lactose 886mg
Crystalline cellulose appropriate amount Carboxymethylcellulose calcium 320mg
Hydroxypropylcellulose 558mg
Carplex 30mg
Magnesium stearate 55mg
Total 5600mg
Similarly, tablets were made using soy isoflavone glycosides instead of soy isoflavones.

Soft capsule curcumin 25mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Carrot extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
Similarly, soft capsules were produced using acetyl soybean isoflavone and soybean isoflavone glycoside in place of soybean isoflavone.

Drink curcumin 30mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Ginseng extract 10mg
Giant extract 10mg
Royal Jelly 100mg
Thiamine nitrate 10mg
Riboflavin sodium phosphate 5mg
Pyridoxine hydrochloride 10mg
Anhydrous caffeine 50mg
Ethanol 1.2L
Ethyl paraoxybenzoate 4mg
Purified water
50 mL bottle in total Similarly, a drink was prepared using soy isoflavone glycosides instead of soy isoflavone.

Powder curcumin 30mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Lactose 2700mg
Corn starch appropriate amount light silicic acid anhydride 5mg
Magnesium stearate 10mg
Total 4000mg (1 packet 2g twice a day)
Similarly, powder was prepared using soy isoflavone instead of soy isoflavone glycoside.

Granule curcumin 25mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Lactose 2700mg
Corn starch appropriate amount crystalline cellulose 300mg
Light anhydrous silicic acid 5mg
Magnesium stearate 10mg
Total 4000mg
Similarly, granules were produced using soy isoflavones instead of soy isoflavone glycosides.

Tablet curcumin 30mg
Cholic acid 140mg
Soy isoflavone glycoside 280mg
Lactose 4000mg
Carboxymethylcellulose calcium 320mg
Hydroxypropylcellulose 74mg
Crystalline cellulose appropriate amount Carplex 30mg
Magnesium stearate 10mg
Total 5484mg (1 tablet 280mg once 5 tablets twice a day)
Similarly, tablets were produced using soy isoflavones instead of soy isoflavone glycosides.

Hard capsule curcumin 25mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Corn starch appropriate amount Magnesium stearate 9mg
Total 1153mg (1 capsule 4 capsules per day)
Similarly, hard capsules were produced using soy isoflavones instead of soy isoflavone glycosides.

Drink curcumin 30mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Ginseng extract 1500mg
Longan Extract 100mg
Garbage extract 300mg
Royal Jelly 150mg
Riboflavin sodium phosphate 10mg
Ethanol 1.2ml
Paraoxybenzoic acid 4mg
Purified water appropriate amount total 50ml
Similarly, a drink was prepared using soy isoflavone instead of soy isoflavone glycoside.

Soft capsule curcumin 45mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Carrot extract 80mg
Banglancon Extract 120mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)

Soft capsule curcumin 45mg
Cholic acid 60mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Carrot extract 100mg
Ouren extract 80mg
Beeswax 55mg
Edible oil
Total 1200mg
Similarly, a soy isoflavone glycoside was used instead of soy isoflavone to prepare a capsule and a capsule.
Similarly, soft capsules were produced using soy isoflavones instead of soy isoflavone glycosides.

  The present invention relates to an effective anticancer agent.

Claims (15)

An anticancer agent comprising cholic acid and / or simnole and / or simnol ester. The anticancer agent according to claim 1, comprising isoflavone and / or isoflavone glycoside. The anticancer agent according to claim 1 or 2, wherein the isoflavone and the isoflavone glycoside are soybean isoflavone and soybean isoflavone glycoside. The anticancer agent according to any one of claims 1 to 3, comprising a pungent substance, a bitter substance, or a sour substance. The anticancer agent according to any one of claims 1 to 4, wherein the pungent substance, the bitter substance or the sour substance is a pungent substance. The anticancer agent according to any one of claims 1 to 5, wherein the pungent substance is curcumin. A vitamin preparation is added, The anticancer agent according to any one of claims 1 to 6. The anticancer agent according to any one of claims 1 to 7, wherein a crude drug is added. 9. The anticancer agent according to claim 8, wherein the crude drug has a corrective effect. Herbal medicines include carrots, carrots, ginseng, taikojin, western ginseng, jade, birch jutsu, sansaku, licorice, and daikon. The anticancer agent according to claim 8 or 9, wherein the anticancer agent is at least one of Taisou), koji (koui), yellow spirit (kosei), and Yotsudan (shiyojin). 9. The herbal medicine is one or more of hawthorn, Shinki, life comb, malt (Bakuga), cereal (Kokuga), chicken inner gold (Kainaikin), and Aki (Agi). Or 9. The anticancer agent according to 9. Herbal medicines are Kakkon, Kashuku, Nikkei, Tanjin, Chinpi, Benjaum (Yakumoso), Shisoyo, Houren, Bakuryou The anticancer agent according to any one of claims 1 to 11, wherein the anticancer agent is at least one selected from the group consisting of), Ita-Ne (Banlankong), Koei (Hokoei), Ayaka (Fennel), Senkyu, and Mushi. Inosine acid is added, The anticancer agent in any one of Claims 1-12 characterized by the above-mentioned. An odd number fatty acid is added, The anticancer agent in any one of Claims 1-13 characterized by the above-mentioned. The anticancer agent according to any one of claims 1 to 14, wherein docosahexaenoic acid is added.