CN102973703A - Compound pure Chinese medicine composition for treating enteritis in livestock, and preparation method thereof - Google Patents

Abstract

The invention relates to a compound pure Chinese medicine composition for treating enteritis in livestock. The compound pure Chinese medicine composition is prepared by mixing the following ingredients in parts by weight: 15-35 parts of suis fellis pulvis, 25-45 parts of mung bean, 15-25 parts of coptidis rhizome, 15-40 parts of cortex phellodendri, 10-30 parts of borneol, 15-35 parts of radix isatidis, and 20-40 parts of flos fophorae. The compound pure Chinese medicine composition has the beneficial effects of being reasonable in formula, and simple to prepare, having no toxic and side effects, as well as no pollution, no drug residue and drug resistance, being ultrafinely crushed, being high in bioavailability and obvious in curative effect, and having special effect in treating the enteritis in livestock, proved clinically.

Description

The compound pure Chinese medicine composition and method of making the same for the treatment of domestic animal enteritis

Technical field

The present invention relates to treat the compound pure Chinese medicine composition and method of making the same of domestic animal enteritis, belong to the animal field of medicaments, particularly a kind of compound pure Chinese medicine composition and method of making the same that is specifically designed to treatment domestic animal enteritis.

Background technology

Domestic animal enteritis is the heavy hyperphlogosis of its intestinal top layer mucosa and deep tissues thereof, clinically take severe diarrhea, dehydration and self poisoning as feature.By its inflammation character, can be divided into mucus, hemorrhagic, suppurative, fiber disposition and gangrenosum acne gastroenteritis.The disease of primary disease is rapid, and General Symptoms worsens fast, and malpractice causes death easily, causes larger economic loss to aquaculture.The less sickness rate of domestic animal age in days is higher, and mortality rate is also higher, is generally between the 5%-16%.

The primary disease pathogenic factor is a lot, mainly contain bacteriovirus infection, feedstuff change improper or go mouldy, change in weather and poisoning etc.Western medical treatment mainly is to clear up gastrointestinal, anti-inflammation, heart tonifying fluid infusion, removes poisoning etc., though received certain effect, the course of disease is dragged longly, and medical expense is too high, and therapeutic effect still can not be satisfactory.And the traditional Chinese medical science thinks that primary disease mainly is to accumulate the infringement intestinal in the damp and hot heresy, and QI and blood hinders and causes that more serious inflammatory disorders occurs the intestinal mucosa deep layer, and Chinese veterinarian is referred to as " intestinal is yellow ".The rule for the treatment of is with heat-clearing and toxic substances removing, logical intestinal intestinal stasis relieving, strengthening the spleen and nourishing the stomach, and effacing the pernicious influence is the rule for the treatment of.

This disease almost spreads all over all livestock culturing countries of the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing the just, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And Western medicine by force, easily produces the problems such as drug resistance and drug residue owing to its toxic and side effects, and clinical practice is very limited or bans use of.

Therefore research and develop that a kind of to treat the having no side effect of domestic animal enteritis, drug residue free, the specific medicament that produces that has no drug resistance be one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability height, successful, have no side effect, have no drug resistance and effective compound pure Chinese medicine composition and method of making the same for the treatment of domestic animal enteritis of drug residue.

Implementation of the present invention is as follows for achieving the above object: a kind of compound pure Chinese medicine compositions for the treatment of domestic animal enteritis, by following component by weight mixed preparing form: Pulvis Fellis Suis 15-35 part, Semen phaseoli radiati 25-45 part, Rhizoma Coptidis 15-25 part, Cortex Phellodendri 15-40 part, Borneolum Syntheticum 10-30 part, Radix Isatidis 15-35 part, Flos Sophorae 20-40 part.

Described various component optimum ratio amount is: 25 parts of Pulvis Fellis Suiss, 35 parts in Semen phaseoli radiati, 20 parts of Rhizoma Coptidis, 25 parts of Cortex Phellodendris, 20 parts of Borneolum Syntheticums, 25 parts of Radix Isatidis, 30 parts in Flos Sophorae.

A kind of preparation method for the treatment of the compound pure Chinese medicine compositions of domestic animal enteritis, carry out as follows:

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing by weight Pulvis Fellis Suis 15-35 part, Semen phaseoli radiati 25-45 part, Rhizoma Coptidis 15-25 part, mix 5-10 minute to even;

(3) take by weighing by weight Cortex Phellodendri 15-40 part, Borneolum Syntheticum 10-30 part, Radix Isatidis 15-35 part, Flos Sophorae 20-40 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Pulvis Fellis Suis: bitter, cold, return lung, gallbladder, liver, large intestine channel, have heat clearing away, moisturize, the function of detoxifcation, relieving cough and asthma; Cure mainly calentura dry thirsty, conjunctival congestion, sore throat, jaundice, asthma, have loose bowels, dysentery, constipation, carbuncle pyogenic infections from tumour or sore etc.

Semen phaseoli radiati: sweet, cool, GUIXIN, stomach warp have heat-clearing and toxic substances removing, a function of the stomach invigorating of relieving summer heat; Cure mainly that diarrhea due to damp-heat, detoxifcation protect the liver, antiallergic etc.

Rhizoma Coptidis: bitter, cold, return spleen, stomach, large intestine, gallbladder, heart channel, have the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder etc.

Cortex Phellodendri: bitter, cold, return kidney, urinary bladder channel, have the function of heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever; Cure mainly damp-heat dysentery, jaundice, pyretic stranguria, sore swollen toxin, eczema, hyperactivity of fire caused by deficiency of YIN etc.

Borneolum Syntheticum: hot, bitter, cold, GUIXIN, spleen, lung meridian have the function of sensible refreshment, heat-clearing and fire-dispersing, reducing swelling and alleviating pain; Cure mainly coma convulsions, laryngopharynx swelling and pain, heat in the heart tongue boil, conjunctival congestion cataracta, sore swollen toxin etc.

Radix Isatidis: bitter, cold, GUIXIN, stomach warp have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.

Flos Sophorae: bitter, be slightly cold, return lung, liver, the heart, large intestine channel, have the function of cooling blood for hemostasis, liver heat removing and eyesight improving; Cure mainly discharging fresh blood stool, dysentery, hematuria, epistaxis etc.

More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, for paathogenic factor and the clinical symptoms of domestic animal enteritis, the performance treating both the principal and secondary aspects of a disease effect.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this seven flavors Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, treatment domestic animal enteritis there is specially good effect, and make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:

Embodiment 1

A kind of compound pure Chinese medicine composition and method of making the same for the treatment of domestic animal enteritis: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing by weight 150 parts of Pulvis Fellis Suiss, 250 parts in Semen phaseoli radiati, 150 parts of Rhizoma Coptidis, mix 5-10 minute to even;

(3) take by weighing by weight 150 parts of Cortex Phellodendris, 100 parts of Borneolum Syntheticums, 150 parts of Radix Isatidis, 200 parts in Flos Sophorae, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of compound pure Chinese medicine composition and method of making the same for the treatment of domestic animal enteritis: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing by weight 250 parts of Pulvis Fellis Suiss, 350 parts in Semen phaseoli radiati, 200 parts of Rhizoma Coptidis, mix 5-10 minute to even;

(3) take by weighing by weight 250 parts of Cortex Phellodendris, 200 parts of Borneolum Syntheticums, 250 parts of Radix Isatidis, 300 parts in Flos Sophorae, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of compound pure Chinese medicine composition and method of making the same for the treatment of domestic animal enteritis: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing by weight 350 parts of Pulvis Fellis Suiss, 450 parts in Semen phaseoli radiati, 250 parts of Rhizoma Coptidis, mix 5-10 minute to even;

(3) take by weighing by weight 400 parts of Cortex Phellodendris, 300 parts of Borneolum Syntheticums, 350 parts of Radix Isatidis, 400 parts in Flos Sophorae, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

The clinical experiment animal selects 75-85 age in days, body weight at 30kg-40kg, and Laboratory Diagnosed is the ill pig of swine enteritis.Ill pig isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experiment was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with " the dysentery health is loose " by specification; Chinese medicine composition group of the present invention can brew product of the present invention (embodiment of the invention 1 prepared compositions) boiled water, and warm water gavages, and each 100 grams-150 grams, are used in conjunction 3-5 days at every day 1-2 time; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.

Table is the field applicable cases contrast of the present invention and other medicines treatment domestic animal enteritis (pig):

Numbering	Group	Mortality rate %	Cure rate %	Symptom rate % is arranged during end
					I	The blank group	6.7	60.0	33.3
II	The loose group of dysentery health	3.3	80.0	16.7
					III	Present composition group	0	90.0	10.0

This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P＜0.01) with the loose group of dysentery health aspect the cure rate.

Safety testing:

Choose 10 of 70 age in days health pig, 5 times according to the embodiment of the invention 1 made compositions recommended dose gavage 10 days, during the medication, health pig is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).

Above-mentioned detailed description of the compound pure Chinese medicine composition and method of making the same of this treatment domestic animal enteritis being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.

Claims (3)

1. compound pure Chinese medicine compositions for the treatment of domestic animal enteritis, it is characterized in that by following component by weight mixed preparing form: Pulvis Fellis Suis 15-35 part, Semen phaseoli radiati 25-45 part, Rhizoma Coptidis 15-25 part, Cortex Phellodendri 15-40 part, Borneolum Syntheticum 10-30 part, Radix Isatidis 15-35 part, Flos Sophorae 20-40 part.

2. the compound pure Chinese medicine compositions for the treatment of according to claim 1 domestic animal enteritis, it is characterized in that by following component by weight mixed preparing form: 25 parts of Pulvis Fellis Suiss, 35 parts in Semen phaseoli radiati, 20 parts of Rhizoma Coptidis, 25 parts of Cortex Phellodendris, 20 parts of Borneolum Syntheticums, 25 parts of Radix Isatidis, 30 parts in Flos Sophorae.

3. the preparation method of the compound pure Chinese medicine compositions of a treatment according to claim 1 and 2 domestic animal enteritis is characterized in that carrying out as follows:

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing by weight Pulvis Fellis Suis 15-35 part, Semen phaseoli radiati 25-45 part, Rhizoma Coptidis 15-25 part, mix 5-10 minute to even;

(3) take by weighing by weight Cortex Phellodendri 15-40 part, Borneolum Syntheticum 10-30 part, Radix Isatidis 15-35 part, Flos Sophorae 20-40 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.