CN102961515B - Compound bee-glue composition for the treatment of swine erysipelas and preparation method thereof - Google Patents
Compound bee-glue composition for the treatment of swine erysipelas and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to field of animal, particularly a kind of compound bee-glue composition for the treatment of swine erysipelas.Said composition by following component by weight mixed preparing form: propolis 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Arctii 15-35 part, Folium Isatidis 15-35 part, Radix Gentianae 15-45 part, Cortex Moutan 15-35 part, Radix Glycyrrhizae 15-40 part, Fructus Gardeniae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Fructus Forsythiae 15-45 part.The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and said composition has no side effect, pollution-free, drug residue free, have no drug resistance, and micronizing, bioavailability are high, curative effect highly significant, and clinical proof has specially good effect to treatment swine erysipelas.
Description
Technical field
The present invention relates to compound bee-glue composition and preparation method thereof for the treatment of swine erysipelas, belong to field of animal, be particularly a kind ofly specifically designed to compound bee-glue composition for the treatment of swine erysipelas and preparation method thereof.
Background technology
Swine erysipelas is acute, the hot infectious disease caused by bacillus rhusiopathiae suis.Be characterized as acute sepsis, Subacute Cutaneous rash block, chronic is polyarthritis and endocarditis.The pig of various age and kind all can occur, and M & M is all between 5%-20%.Primary disease all can occur throughout the year, is one of principal disease of serious harm pig industry.
This disease is all pig-raising countries of throughout world almost, are widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug, Chinese medicine is because its prescription is unreasonable or just simply pulverize, and particle diameter is excessive, and drug release is comparatively slow, and cause its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug has drug residue due to life-time service and easily produces drug resistance, and worse and worse, and drug residue causes that outlet is limited and harm people are healthy to its clinical effectiveness, thus the use of antimicrobial drug is very restricted.
Therefore researching and developing a kind of drug residue free, specific medicament of producing of having no drug resistance for the treatment of swine erysipelas is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, preparation is simple, micronizing, bioavailability are high, successful, to have no drug resistance and the compound bee-glue composition and preparation method thereof of effective treatment swine erysipelas of drug residue.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of swine erysipelas, by following component by weight mixed preparing form: propolis 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Arctii 15-35 part, Folium Isatidis 15-35 part, Radix Gentianae 15-45 part, Cortex Moutan 15-35 part, Radix Glycyrrhizae 15-40 part, Fructus Gardeniae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Fructus Forsythiae 15-45 part.
On the basis of such scheme, by following component by weight mixed preparing form: propolis 25 parts, Radix Et Rhizoma Rhei 25 parts, Fructus Arctii 25 parts, Folium Isatidis 25 parts, Radix Gentianae 30 parts, Cortex Moutan 25 parts, 25 parts, Radix Glycyrrhizae, Fructus Gardeniae 30 parts, Pericarpium Citri Reticulatae 30 parts, Fructus Forsythiae 30 parts.
Treat a preparation method for the compound bee-glue composition of swine erysipelas, carry out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Arctii 15-35 part, Folium Isatidis 15-35 part, Radix Gentianae 15-45 part by weight, mix 5-10 minute to even;
(3) take Cortex Moutan 15-35 part, Radix Glycyrrhizae 15-40 part, Fructus Gardeniae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Fructus Forsythiae 15-45 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, returns spleen, stomach warp, has anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improves immunity, antiallergic is oxidized, the function of the gastrointestinal mucosa that stops blooding, protects.
Radix Et Rhizoma Rhei: bitter, cold, returns large intestine, spleen, stomach, liver, pericardium channel, has the function of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass blood stasis expelling; Cure mainly excess-heat constipation, combined symptoms, skin ulcer yellow furunculosis, conjunctival congestion and swelling pain, enteritis etc.
Fructus Arctii: pungent, bitter, cold, attaches to the lung and stomach meridians, has the function of dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat; Cure mainly affection due to external wind and heat, cough and asthma, laryngopharynx swelling and pain, carbuncle sore tumefacting virus etc.
Folium Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly calentura and send out speckle, laryngopharynx swelling and pain, hematodiarrhoea, jaundice, carbuncle, erysipelas etc.
Radix Gentianae: bitter, cold, returns liver, gallbladder meridian, has eliminating pathogen in the liver gallbladder excess-fire, function except damp-heat in lower-JIAO; Cure mainly jaundice due to damp-heat, conjunctival congestion and swelling pain, eczema pruritus etc.
Cortex Moutan: bitter, acrid, cold, returns liver, the heart, kidney channel, has the function of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling; Cure mainly maculae caused by violent heat pathogen, epistaxis, have blood in stool, hematuria, traumatic injury, carbuncle sore tumefacting virus etc.
Radix Glycyrrhizae: sweet, flat, returns lung, the heart, spleen channel, has invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning.
Fructus Gardeniae: bitter, cold, GUIXIN, lung, tri-jiao channel, have the function of eliminating fire and detoxication, clearing away heat and promoting diuresis, removing heat from blood; Cure mainly three burnt intenseness of heat, jaundice due to damp-heat, pyretic stranguria, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, heat in blood epistaxis etc.
Pericarpium Citri Reticulatae: bitter, pungent, warm, returns lung, spleen channel, has the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, stomachache, tripe be swollen, have loose bowels, productive cough due to phlegm-damp etc.
Fructus Forsythiae: bitter, cold, returns lung, the heart, small intestine meridian, has the function of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Cure mainly epidemic febrile disease heating, skin ulcer general edema with yellowish skin poison etc.
All taste Chinese medicine is according to Chinese medical theory compatible combination above, for the pathogenic microorganism of swine erysipelas, clinical symptoms and pathological change, plays the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and draw materials wide, micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Ten Herbs, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, specially good effect is had to treatment swine erysipelas, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively ensure that people's is healthy.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of compound bee-glue composition for the treatment of swine erysipelas and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 150 parts, Radix Et Rhizoma Rhei 150 parts, Fructus Arctii 150 parts, Folium Isatidis 150 parts, Radix Gentianae 150 parts by weight, mix 5-10 minute to even;
(3) take Cortex Moutan 150 parts, 150 parts, Radix Glycyrrhizae, Fructus Gardeniae 150 parts, Pericarpium Citri Reticulatae 150 parts, Fructus Forsythiae 150 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of swine erysipelas and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 250 parts, Radix Et Rhizoma Rhei 250 parts, Fructus Arctii 250 parts, Folium Isatidis 250 parts, Radix Gentianae 300 parts by weight, mix 5-10 minute to even;
(3) take Cortex Moutan 250 parts, 250 parts, Radix Glycyrrhizae, Fructus Gardeniae 300 parts, Pericarpium Citri Reticulatae 300 parts, Fructus Forsythiae 300 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of swine erysipelas and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 350 parts, Radix Et Rhizoma Rhei 350 parts, Fructus Arctii 350 parts, Folium Isatidis 350 parts, Radix Gentianae 450 parts by weight, mix 5-10 minute to even;
(3) take Cortex Moutan 350 parts, 400 parts, Radix Glycyrrhizae, Fructus Gardeniae 450 parts, Pericarpium Citri Reticulatae 450 parts, Fructus Forsythiae 450 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 75-85 age in days, body weight at 35kg-45kg, and Laboratory Diagnosed is the ill pig of swine erysipelas.Ill pig isolation raised separately, complete feed of feeding, and be divided into 3 groups at random, often organize 30,3 groups of feeding environments are identical, and experiment carries out 5 days altogether; Blank group is left intact, and drug control group " pig erysipelas health is fallen apart " by specification uses treatment; Chinese medicine composition group of the present invention can by product of the present invention (compositions obtained by the embodiment of the present invention 1) the ill pig of feeding etc., day dose be: by the every 100g of the present invention, spice 280kg feeds, every day 2-3 time, is used in conjunction 3-5 day; Reached the object of disease therapy by gastrointestinal absorption after oral.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result (testing the 5th day) at the end of experiment.
Table is that the situation that the present invention and other medicines treat swine erysipelas contrasts:
| Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
| I | Blank group | 13.3 | 60.9 | 26.7 |
| II | Pig erysipelas health is fallen apart group | 6.7 | 80.0 | 13.3 |
| III | Present composition group | 3.3 | 90.0 | 6.7 |
This clinical effectiveness statistical analysis, present composition treatment group and pig erysipelas health fall apart group in cure rate compared with difference extremely significantly (P < 0.01).
Safety testing:
Choose 70 age in days health pig 10,5 times of spices according to the made compositions recommended dose of the embodiment of the present invention 1 are fed 10 days, during medication, health pig is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.
Above-mentioned detailed description of compound bee-glue composition of this treatment swine erysipelas and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (2)
1. treat a compound bee-glue composition for swine erysipelas, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Arctii 15-35 part, Folium Isatidis 15-35 part, Radix Gentianae 15-45 part, Cortex Moutan 15-35 part, Radix Glycyrrhizae 15-40 part, Fructus Gardeniae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Fructus Forsythiae 15-45 part;
Preparation method is carried out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Arctii 15-35 part, Folium Isatidis 15-35 part, Radix Gentianae 15-45 part by weight, mix 5-10 minute to even;
(3) take Cortex Moutan 15-35 part, Radix Glycyrrhizae 15-40 part, Fructus Gardeniae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Fructus Forsythiae 15-45 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
2. the compound bee-glue composition for the treatment of swine erysipelas according to claim 1, it is characterized in that by following component by weight mixed preparing form: propolis 25 parts, Radix Et Rhizoma Rhei 25 parts, Fructus Arctii 25 parts, Folium Isatidis 25 parts, Radix Gentianae 30 parts, Cortex Moutan 25 parts, 25 parts, Radix Glycyrrhizae, Fructus Gardeniae 30 parts, Pericarpium Citri Reticulatae 30 parts, Fructus Forsythiae 30 parts.
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| CN105362430A (en) * | 2015-11-15 | 2016-03-02 | 衡阳市金凤牲猪养殖专业合作社 | Drug for preventing and curing swine erysipelas, and preparation method thereof |
| CN107281427A (en) * | 2017-06-28 | 2017-10-24 | 石阡县金桥农牧发展有限责任公司 | A kind of feed addictive for preventing and treating brickpox |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078419A (en) * | 2010-12-24 | 2011-06-01 | 任先武 | Medicament for preventing and treating porcine reproductive and respiratory syndrome (PRRS) and preparation method thereof |
| CN102727669A (en) * | 2012-06-20 | 2012-10-17 | 青岛绿曼生物工程有限公司 | Compound propolis composition used for treating swine erysipelas, and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078419A (en) * | 2010-12-24 | 2011-06-01 | 任先武 | Medicament for preventing and treating porcine reproductive and respiratory syndrome (PRRS) and preparation method thereof |
| CN102727669A (en) * | 2012-06-20 | 2012-10-17 | 青岛绿曼生物工程有限公司 | Compound propolis composition used for treating swine erysipelas, and preparation method thereof |
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| Title |
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| 动物"热性病"的中兽医辩证施治;沈少成等;《江西畜牧兽医杂志》;20111231(第5期);第47页 * |
| 猪丹毒的治疗;佚名;《吉林畜牧兽医》;20031231(第7期);第42页 * |
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