CN102600325B - Compound propolis composition for treatment of porcine contagious pleuropneumonia and preparation method thereof - Google Patents
Compound propolis composition for treatment of porcine contagious pleuropneumonia and preparation method thereof Download PDFInfo
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- CN102600325B CN102600325B CN201110434282.2A CN201110434282A CN102600325B CN 102600325 B CN102600325 B CN 102600325B CN 201110434282 A CN201110434282 A CN 201110434282A CN 102600325 B CN102600325 B CN 102600325B
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Abstract
The invention relates to a compound propolis composition for treatment of porcine contagious pleuropneumonia and a preparation method thereof, relating to the field of animal medicine. The preparation method comprises the following steps of: (1) performing ultrafine grinding of components in a formula, and screening with a 700-mesh sieve; (2) weighing 15-35 parts of propolis, 15-35 parts of astragalus mongholicus, 15-35 parts of tussilago, 15-35 parts of prepared pinellia tuber and 15-45 parts of jasmine by weight, and mixing for 5-10 minutes to prepare uniform mixture; (3) weighing 15-35 parts of fructus forsythiae, 15-40 parts of scutellaria baicalensis, 15-45 parts of cortex mori radicis, 15-45 parts of lindley eupatorium and 15-45 parts of pericarpium citri reticulatae by weight, and mixing for 5-10 minutes to prepare uniform mixture; and (4) mixing the mixture prepared in (2) and the mixture prepared in (3) for 10-15 minutes to prepare a mixture, thereby obtaining the compound propolis composition. The compound propolis composition has the beneficial effects of reasonable formula, simple preparation, no toxic or side effects, no pollution, no drug residue, no drug resistance, ultrafine grinding, high bioavailability and significant efficacy. Clinical applications prove that the composition has specially good effects on treatment of the porcine contagious pleuropneumonia.
Description
Technical field
The present invention relates to animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment porcine contagious pleuropneumonia and preparation method thereof.
Background technology
Porcine contagious pleuropneumonia is a kind of lethal respiratory infectious disease being caused by Actinobacillus pleuropneumoniae, taking acute hemorrhagic fiber disposition pleuropneumonia and Focal necrotizing pneumonia as feature.The pig of various ages and kind all can occur, and M & M is all more than 20%.Primary disease all can occur throughout the year, is one of principal disease of serious harm pig industry.
This disease almost spreads all over all countries of raising pigs of the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug is because life-time service has drug residue and easily produces drug resistance, and worse and worse, and drug residue causes exporting limited and harm people are healthy for its clinical effectiveness, thereby the use of antimicrobial drug is very restricted.
Therefore research and develop a kind of drug residue free for the treatment of porcine contagious pleuropneumonia, the specific medicament producing that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the compound bee-glue composition of effective treatment porcine contagious pleuropneumonia of drug residue and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of porcine contagious pleuropneumonia, by following component by weight mixed preparing form: propolis 15-35 part, Radix Astragali 15-35 part, Flos Farfarae 15-35 part, Rhizoma Pinelliae Preparatum 15-35 part, Fructus Gardeniae 15-45 part, Fructus Forsythiae 15-35 part, Radix Scutellariae 15-40 part, Cortex Mori 15-45 part, Herba Eupatorii Lindleyani 15-45 part, Pericarpium Citri Reticulatae 15-45 part.
On the basis of such scheme, described various component optimum ratio amounts are: 25 parts of propolis, 25 parts of the Radixs Astragali, 25 parts of Flos Farfaraees, 25 parts of Rhizoma Pinelliae Preparatum, 30 parts of Fructus Gardeniaes, 25 parts of Fructus Forsythiaes, 25 parts of Radix Scutellariaes, 30 parts of Cortex Mori, 30 parts of Herba Eupatorii Lindleyanis, 30 parts of Pericarpium Citri Reticulataes.
Treat a preparation method for the compound bee-glue composition of porcine contagious pleuropneumonia, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Radix Astragali 15-35 part, Flos Farfarae 15-35 part, Rhizoma Pinelliae Preparatum 15-35 part, Fructus Gardeniae 15-45 part, mix 5-10 minute to even;
(3) take by weight Fructus Forsythiae 15-35 part, Radix Scutellariae 15-40 part, Cortex Mori 15-45 part, Herba Eupatorii Lindleyani 15-45 part, Pericarpium Citri Reticulatae 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, return spleen, stomach warp, the function that there is anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic is oxidized, stops blooding, protects gastrointestinal mucosa.
The Radix Astragali: sweet, tepor, return spleen, lung meridian, there is the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.
Flos Farfarae: micro-hardship, pungent, warm, return lung meridian, there is the function of nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm; Cure mainly cough, asthma etc.
Rhizoma Pinelliae Preparatum: pungent, warm, return spleen, stomach, lung meridian, there is the function of drying dampness to eliminate phlegm; Cure mainly damp-phlegm cough with asthma etc.
Radix Scutellariae: bitter, cold, return gallbladder, lung, spleen, large intestine, small intestine meridian, there is the function of heat clearing and damp drying, eliminating fire and detoxication, hemostasis; Cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus etc.
Fructus Gardeniae: bitter, cold, GUIXIN, lung, tri-jiao channel, have the function of eliminating fire and detoxication, clearing away heat and promoting diuresis, removing heat from blood; Cure mainly three warmers intenseness of heat, jaundice due to damp-heat, pyretic stranguria, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, heat in blood epistaxis etc.
Fructus Forsythiae: bitter, be slightly cold, return lung, the heart, small intestine meridian, there is the function of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Cure mainly epidemic febrile disease heating, skin ulcer general edema with yellowish skin poison etc.
Cortex Mori: sweet, cold, return lung meridian, there is the function of eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema; Cure mainly dyspnea and cough due to lung-heat, edema abdominal distention, oliguria etc.
Herba Eupatorii Lindleyani: bitter, flat, return lung meridian, there is the function of expectorant cough suppressant and anti-asthmatic; Cure mainly abundant expectoration, cough, asthma etc.
Pericarpium Citri Reticulatae: bitter, pungent, warm, return lung, spleen channel, there is the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, abdominal distention, tripe is swollen, have loose bowels, productive cough due to phlegm-damp etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for pathogenic microorganism, clinical symptoms and the pathological change of porcine contagious pleuropneumonia, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Ten Herbs, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, treatment porcine contagious pleuropneumonia is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively ensured that people's is healthy.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of compound bee-glue composition for the treatment of porcine contagious pleuropneumonia and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of propolis, 150 parts of the Radixs Astragali, 150 parts of Flos Farfaraees, 150 parts of Rhizoma Pinelliae Preparatum, 150 parts of Fructus Gardeniaes, mix 5-10 minute to even;
(3) take by weight 150 parts of Fructus Forsythiaes, 150 parts of Radix Scutellariaes, 150 parts of Cortex Mori, 150 parts of Herba Eupatorii Lindleyanis, 150 parts of Pericarpium Citri Reticulataes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of porcine contagious pleuropneumonia and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of propolis, 250 parts of the Radixs Astragali, 250 parts of Flos Farfaraees, 250 parts of Rhizoma Pinelliae Preparatum, 300 parts of Fructus Gardeniaes, mix 5-10 minute to even;
(3) take by weight 250 parts of Fructus Forsythiaes, 250 parts of Radix Scutellariaes, 300 parts of Cortex Mori, 300 parts of Herba Eupatorii Lindleyanis, 300 parts of Pericarpium Citri Reticulataes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of porcine contagious pleuropneumonia and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of propolis, 350 parts of the Radixs Astragali, 350 parts of Flos Farfaraees, 350 parts of Rhizoma Pinelliae Preparatum, 450 parts of Fructus Gardeniaes, mix 5-10 minute to even;
(3) take by weight 350 parts of Fructus Forsythiaes, 400 parts of Radix Scutellariaes, 450 parts of Cortex Mori, 450 parts of Herba Eupatorii Lindleyanis, 450 parts of Pericarpium Citri Reticulataes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
By the ill pig of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 240kg feeds, and the 450kg that drinks water, every day 2-3 time, is used in conjunction 3-5 day; After oral, reach the object for the treatment of disease by gastrointestinal absorption.
Table is the field applicable cases contrast of the present invention and other medicines treatment porcine contagious pleuropneumonia:
| Numbering | Group | Mortality rate % | Cure rate % | When end, there is symptom rate % |
| I | Blank group | 25.5 | 52.9 | 21.6 |
| II | The pig pleuropneumonia health group of faling apart | 10.5 | 79.4 | 10.1 |
| III | Present composition group | 5.9 | 90.0 | 4.1 |
This clinical effectiveness statistical analysis, the loose group of present composition treatment group and pig pleuropneumonia health extremely significantly (P < 0.01) of difference compared with aspect cure rate.
The above-mentioned detailed description that compound bee-glue composition to this treatment porcine contagious pleuropneumonia and preparation method thereof carries out with reference to embodiment; illustrative instead of determinate; can list several embodiment according to institute's limited range; therefore in the variation and the amendment that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a compound bee-glue composition for porcine contagious pleuropneumonia, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Radix Astragali 15-35 part, Flos Farfarae 15-35 part, Rhizoma Pinelliae Preparatum 15-35 part, Fructus Gardeniae 15-45 part, Fructus Forsythiae 15-35 part, Radix Scutellariae 15-40 part, Cortex Mori 15-45 part, Herba Eupatorii Lindleyani 15-45 part, Pericarpium Citri Reticulatae 15-45 part.
2. a kind of compound bee-glue composition for the treatment of porcine contagious pleuropneumonia according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of the Radixs Astragali, 25 parts of Flos Farfaraees, 25 parts of Rhizoma Pinelliae Preparatum, 30 parts of Fructus Gardeniaes, 25 parts of Fructus Forsythiaes, 25 parts of Radix Scutellariaes, 30 parts of Cortex Mori, 30 parts of Herba Eupatorii Lindleyanis, 30 parts of Pericarpium Citri Reticulataes.
3. a preparation method for the compound bee-glue composition for the treatment of porcine contagious pleuropneumonia according to claim 1, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Radix Astragali 15-35 part, Flos Farfarae 15-35 part, Rhizoma Pinelliae Preparatum 15-35 part, Fructus Gardeniae 15-45 part, mix 5-10 minute to even;
(3) take by weight Fructus Forsythiae 15-35 part, Radix Scutellariae 15-40 part, Cortex Mori 15-45 part, Herba Eupatorii Lindleyani 15-45 part, Pericarpium Citri Reticulatae 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110434282.2A CN102600325B (en) | 2011-12-22 | 2011-12-22 | Compound propolis composition for treatment of porcine contagious pleuropneumonia and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110434282.2A CN102600325B (en) | 2011-12-22 | 2011-12-22 | Compound propolis composition for treatment of porcine contagious pleuropneumonia and preparation method thereof |
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| CN102600325B true CN102600325B (en) | 2014-07-09 |
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| CN104256168B (en) * | 2014-09-28 | 2016-05-11 | 山东新希望六和集团有限公司 | One boar functional feed and preparation method thereof |
| CN105998282A (en) * | 2016-05-27 | 2016-10-12 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medicinal composition for treating contagious bovine pleuropneumonia in cows and preparation method of traditional Chinese medicinal composition |
| CN106668066A (en) * | 2017-01-16 | 2017-05-17 | 安徽天安生物科技股份有限公司 | Chinese and western medicine preparation for treating porcine contagious pleuropneumoniae |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1110579A (en) * | 1994-04-19 | 1995-10-25 | 陈辉 | Medicine for prevention and cure of epidemic diseases of animal and birds and production method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1110579A (en) * | 1994-04-19 | 1995-10-25 | 陈辉 | Medicine for prevention and cure of epidemic diseases of animal and birds and production method |
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