CN103585407A - Traditional Chinese medicine composition for treating swine infectious atrophic rhinitis and preparation method of composition - Google Patents
Traditional Chinese medicine composition for treating swine infectious atrophic rhinitis and preparation method of composition Download PDFInfo
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Abstract
The invention relates to traditional Chinese medicine composition for treating swine infectious atrophic rhinitis. The traditional Chinese medicine composition is prepared by components in parts by weight as follows: 15-35 parts of rheum officinale, 15-35 parts of herba cirsii japonici carbonisatum, 15-35 parts of subprostrate sophora, 15-35 parts of lonicera confusa, 15-45 parts of Chinese yam, 15-35 parts of hawthorn, 15-50 parts of liquorice, 15-45 parts of rhizome nardostachyos, 15-35 parts of herba pyrrosiae, 15-35 parts of salvia chinensis, 15-45 parts of concha haliotidis and 15-35 parts of rhizoma acori graminei. The traditional Chinese medicine composition has the benefits of reasonable formula, simplification of preparation, no toxic or side effects, no pollution, no medicine residues, no medicine resistance, superfine grinding, high bioavailability and obvious curative effect; and clinical tests prove that the composition has a specific effect in treating the swine infectious atrophic rhinitis.
Description
Technical field
The present invention relates to Chinese medicine composition for the treatment of pig infectious atrophic rhinitis and preparation method thereof, belong to animal field of medicaments, particularly a kind of Chinese medicine composition that is specifically designed to treatment pig infectious atrophic rhinitis and preparation method thereof.
Background technology
Pig infectious atrophic rhinitis is a kind of universal pandemic serious contact upper respiratory infectious disease being caused by pig toxigenicity pasteurella multocida and bronchus deteriorated blood bordetella bacilli, and take clinically the distortion of sneeze, nasal bone, turbinates atrophy or disappearance and deviation of nasal septum is feature.The pig of various ages and kind all can occur, and case fatality rate is all between 2%-10%, and infected pigs can cause serious feed consumption to increase, deliver for sale delay etc.Primary disease all can occur throughout the year, is one of principal disease of serious harm pig industry.
This disease almost spreads all over all countries of raising pigs in the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug is because life-time service has drug residue and easily produces drug resistance, and worse and worse, and drug residue causes exporting limited and harm people are healthy for its clinical effectiveness, thereby the use of antimicrobial drug is very restricted.
Therefore research and develop and a kind ofly treat the drug residue free of pig infectious atrophic rhinitis, the specific medicament producing that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the Chinese medicine composition of effective treatment pig infectious atrophic rhinitis of drug residue and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of Chinese medicine composition for the treatment of pig infectious atrophic rhinitis, by following component by weight mixed preparing form: Radix Et Rhizoma Rhei 15-35 part, Carbonized Cirsium japonicum 15-35 part, Radix Sophorae Tonkinensis 15-35 part, Flos Lonicerae 15-35 part, Rhizoma Dioscoreae 15-45 part, Fructus Crataegi 15-35 part, Radix Glycyrrhizae 15-50 part, Radix Et Rhizoma Nardostachyos 15-45 part, Folium Pyrrosiae 15-35 part, Herba Salviae Chinensis 15-35 part, Concha Haliotidis 15-45 part, Rhizoma Acori Graminei 15-35 part.
Described various component optimum ratio amount is: 25 parts of Radix Et Rhizoma Rhei, 25 parts of Carbonized Cirsium japonicum, 25 parts of Radix Sophorae Tonkinensiss, 25 parts of Flos Lonicerae, 30 parts of Rhizoma Dioscoreaes, 25 parts of Fructus Crataegis, 30 parts, Radix Glycyrrhizae, 30 parts of Radix Et Rhizoma Nardostachyos, 25 parts of Folium Pyrrosiae, 25 parts of Herba Salviae Chinensiss, 30 parts of Concha Haliotidis, 25 parts of Rhizoma Acori Graminei.
A preparation method for the Chinese medicine composition of pig infectious atrophic rhinitis, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Radix Et Rhizoma Rhei 15-35 part, Carbonized Cirsium japonicum 15-35 part, Radix Sophorae Tonkinensis 15-35 part, Flos Lonicerae 15-35 part, Rhizoma Dioscoreae 15-45 part, Fructus Crataegi 15-35 part, mix 5-10 minute to even;
(3) take by weight Radix Glycyrrhizae 15-50 part, Radix Et Rhizoma Nardostachyos 15-45 part, Folium Pyrrosiae 15-35 part, Herba Salviae Chinensis 15-35 part, Concha Haliotidis 15-45 part, Rhizoma Acori Graminei 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Radix Et Rhizoma Rhei: bitter, cold, return stomach, the heart, spleen, large intestine, Liver Channel, there is the function of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass blood stasis expelling; Cure mainly excess-heat constipation, combined symptoms, the yellow furunculosis of skin ulcer, conjunctival congestion and swelling pain etc.
Carbonized Cirsium japonicum: bitter, puckery, cool, GUIXIN, Liver Channel, have the function of cooling blood for hemostasis; Cure mainly epistaxis, have blood in stool, hematuria, metrorrhagia etc.
Radix Sophorae Tonkinensis: bitter, cold, return stomach, lung meridian, there is the function of heat-clearing and toxic substances removing, detumescence sore-throat relieving, expelling phlegm for arresting cough; Cure mainly laryngopharynx swelling and pain, cough due to lung-heat, the yellow furunculosis of skin ulcer etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Flos Lonicerae: sweet, cold, return stomach, the heart, lung meridian, there is the function of heat-clearing and toxic substances removing, heat radiation dispelling wind; Cure mainly laryngopharynx swelling and pain, cough due to lung-heat, epidemic febrile disease heating, anemopyretic cold, toxic-heat and blood stasis, mammary swelling, carbuncle sore tumefacting virus etc.
Rhizoma Dioscoreae: sweet, flat, return stomach, spleen, kidney channel, have that spleen reinforcing nourishing the stomach, lung benefiting are promoted the production of body fluid, the function of the kidney invigorating arresting seminal emission; Cure mainly weakness of the spleen and stomach, inappetence, diarrhea due to hypofunction of the spleen, asthenia cough with asthma, spermatorrhea, leukorrhagia, frequent micturition number etc.
Fructus Crataegi: sweet, sour, return stomach, spleen, Liver Channel, there is the function of promoting digestion and removing stagnation, circulation of qi promoting dissipating blood stasis; Cure mainly dyspeptic abdominal flatulence, dyspepsia, prolonged lochia etc.
Radix Et Rhizoma Nardostachyos: sweet, pungent, warm, return stomach, spleen channel, the function that there is regulating QI to relieve pain, cold expelling dampness, is amusing and whets the appetite; Cure mainly cold-damp disturbing the spleen, tripe distention and fullness in the abdomen, skin infection etc.
Folium Pyrrosiae: sweet, bitter, be slightly cold, return lung, urinary bladder channel, there is the function of inducing diuresis for treating stranguria syndrome, cooling blood for hemostasis, clearing away lung-heat to relieve cough; Cure mainly difficulty in urination, pyretic stranguria, hematuria, epistaxis, lung-heat cough with asthma etc.
Herba Salviae Chinensis: pungent, bitter, flat, return lung, urinary bladder channel, there is the function of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain; Cure mainly muscles and bones pain, carbuncle sore tumefacting virus, tripe abdominal distention and pain etc.
Concha Haliotidis: become, tremble with fear, return Liver Channel, there is the function of suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving; Cure mainly that wind-heat of liver channel, conjunctival congestion and swelling pain, liver-yang are got angry, corneal nebula cataract etc.
Rhizoma Acori Graminei: acrid, bitter, warm, GUIXIN, stomach warp, have the function of the eliminating phlegm of having one's ideas straightened out, removing dampness to restore normal function of the stomach; Cure mainly that coma, epilepsy, cold-damp are had loose bowels, tripe is swollen etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for pathogenic microorganism, clinical symptoms and the pathological change of pig infectious atrophic rhinitis, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this 12 taste Chinese medicine, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, treatment pig infectious atrophic rhinitis is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of Chinese medicine composition for the treatment of pig infectious atrophic rhinitis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of Radix Et Rhizoma Rhei, 150 parts of Carbonized Cirsium japonicum, 150 parts of Radix Sophorae Tonkinensiss, 150 parts of Flos Lonicerae, 150 parts of Rhizoma Dioscoreaes, 150 parts of Fructus Crataegis, mix 5-10 minute to even;
(3) take by weight 150 parts, Radix Glycyrrhizae, 150 parts of Radix Et Rhizoma Nardostachyos, 150 parts of Folium Pyrrosiae, 150 parts of Herba Salviae Chinensiss, 150 parts of Concha Haliotidis, 150 parts of Rhizoma Acori Graminei, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of Chinese medicine composition for the treatment of pig infectious atrophic rhinitis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of Radix Et Rhizoma Rhei, 250 parts of Carbonized Cirsium japonicum, 250 parts of Radix Sophorae Tonkinensiss, 250 parts of Flos Lonicerae, 300 parts of Rhizoma Dioscoreaes, 250 parts of Fructus Crataegis, mix 5-10 minute to even;
(3) take by weight 300 parts, Radix Glycyrrhizae, 300 parts of Radix Et Rhizoma Nardostachyos, 250 parts of Folium Pyrrosiae, 250 parts of Herba Salviae Chinensiss, 300 parts of Concha Haliotidis, 250 parts of Rhizoma Acori Graminei, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of Chinese medicine composition for the treatment of pig infectious atrophic rhinitis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of Radix Et Rhizoma Rhei, 350 parts of Carbonized Cirsium japonicum, 350 parts of Radix Sophorae Tonkinensiss, 350 parts of Flos Lonicerae, 450 parts of Rhizoma Dioscoreaes, 350 parts of Fructus Crataegis, mix 5-10 minute to even;
(3) take by weight 500 parts, Radix Glycyrrhizae, 450 parts of Radix Et Rhizoma Nardostachyos, 350 parts of Folium Pyrrosiae, 350 parts of Herba Salviae Chinensiss, 450 parts of Concha Haliotidis, 350 parts of Rhizoma Acori Graminei, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
It is the ill pig of pig infectious atrophic rhinitis that clinical experiment animal is selected Laboratory Diagnosed.Ill pig isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experiment is carried out 10 days altogether; Blank group is left intact, and medicine matched group is used treatment by institute's control drug by its description; Chinese medicine composition group of the present invention can be by product of the present invention (the prepared compositions of the embodiment of the present invention 2) the ill pig of feeding etc., and a day dose is: by the every 100g of the present invention, spice 230kg feeds, and the 430kg that drinks water, is used in conjunction 3-5 day at every day 2-3 time; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result when following table is experiment end.
Efficacy assessment standard:
The clinical symptom disappearance such as healing: spirit is normal, searches for food drinking-water normally, and breathing is normal, and feces is normal, turbinates is normal, pig nasal secretion laboratory detects and has no pasteurella multocida and bronchus deteriorated blood bordetella bacilli etc.
During end, there is symptom: clinical symptoms is not improved and even increased the weight of.
Table is the field applicable cases contrast of the present invention and other medicines treatment pig infectious atrophic rhinitis:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 40 | 0 | 60 |
| II | The pig BIYANKANG group of faling apart | 10 | 66.7 | 23.3 |
| III | Present composition group | 6.7 | 76.7 | 16.6 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P < 0.01) with the loose group of pig BIYANKANG aspect cure rate.
Safety testing:
Choose 10 of 90 age in days health pig, 5 times of spices according to the made compositions recommended dose of the embodiment of the present invention 2 are fed 10 days, during medication, health pig is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of Chinese medicine composition of this treatment pig infectious atrophic rhinitis and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a Chinese medicine composition for pig infectious atrophic rhinitis, it is characterized in that by following component by weight mixed preparing form: Radix Et Rhizoma Rhei 15-35 part, Carbonized Cirsium japonicum 15-35 part, Radix Sophorae Tonkinensis 15-35 part, Flos Lonicerae 15-35 part, Rhizoma Dioscoreae 15-45 part, Fructus Crataegi 15-35 part, Radix Glycyrrhizae 15-50 part, Radix Et Rhizoma Nardostachyos 15-45 part, Folium Pyrrosiae 15-35 part, Herba Salviae Chinensis 15-35 part, Concha Haliotidis 15-45 part, Rhizoma Acori Graminei 15-35 part.
2. the Chinese medicine composition for the treatment of pig infectious atrophic rhinitis according to claim 1, is characterized in that described various component optimum ratio amount is: 25 parts of Radix Et Rhizoma Rhei, 25 parts of Carbonized Cirsium japonicum, 25 parts of Radix Sophorae Tonkinensiss, 25 parts of Flos Lonicerae, 30 parts of Rhizoma Dioscoreaes, 25 parts of Fructus Crataegis, 30 parts, Radix Glycyrrhizae, 30 parts of Radix Et Rhizoma Nardostachyos, 25 parts of Folium Pyrrosiae, 25 parts of Herba Salviae Chinensiss, 30 parts of Concha Haliotidis, 25 parts of Rhizoma Acori Graminei.
3. a preparation method for the Chinese medicine composition for the treatment of pig infectious atrophic rhinitis according to claim 1 and 2, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Radix Et Rhizoma Rhei 15-35 part, Carbonized Cirsium japonicum 15-35 part, Radix Sophorae Tonkinensis 15-35 part, Flos Lonicerae 15-35 part, Rhizoma Dioscoreae 15-45 part, Fructus Crataegi 15-35 part, mix 5-10 minute to even;
(3) take by weight Radix Glycyrrhizae 15-50 part, Radix Et Rhizoma Nardostachyos 15-45 part, Folium Pyrrosiae 15-35 part, Herba Salviae Chinensis 15-35 part, Concha Haliotidis 15-45 part, Rhizoma Acori Graminei 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106689758A (en) * | 2017-03-06 | 2017-05-24 | 长沙瑞多康生物科技有限公司 | Feed for preventing swine infectious atrophic rhinitis |
| CN106901018A (en) * | 2017-03-06 | 2017-06-30 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention infectious atrophic rhinitis of pig |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102406879A (en) * | 2011-11-25 | 2012-04-11 | 荣成市交通诊所 | Chinese medicine composition for treating rhinitis |
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| CN102406879A (en) * | 2011-11-25 | 2012-04-11 | 荣成市交通诊所 | Chinese medicine composition for treating rhinitis |
Non-Patent Citations (2)
| Title |
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| 董志刚等: "中西结合防治猪传染性萎缩性鼻炎", 《今日畜牧兽医》 * |
| 黄平: "中草药防治猪传染性萎缩性鼻炎", 《中兽医医药杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106689758A (en) * | 2017-03-06 | 2017-05-24 | 长沙瑞多康生物科技有限公司 | Feed for preventing swine infectious atrophic rhinitis |
| CN106901018A (en) * | 2017-03-06 | 2017-06-30 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention infectious atrophic rhinitis of pig |
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