CN103877471A - Traditional Chinese medicinal composition for treating porcine viral diarrhea and preparation method thereof - Google Patents

Traditional Chinese medicinal composition for treating porcine viral diarrhea and preparation method thereof Download PDF

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CN103877471A
CN103877471A CN201410112217.1A CN201410112217A CN103877471A CN 103877471 A CN103877471 A CN 103877471A CN 201410112217 A CN201410112217 A CN 201410112217A CN 103877471 A CN103877471 A CN 103877471A
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chinese medicine
rhizoma
pig
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CN103877471B (en
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周庆福
刘文利
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Fusite Animal Husbandary Science-Technology Co., Ltd., Nanjing
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Qingdao Lvman Bioengineering Co Ltd
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Abstract

The invention relates to a traditional Chinese medicinal composition for treating porcine viral diarrhea. The composition is prepared by mixing the following components in parts by weight: 15-35 parts of indigo naturalis, 20-40 parts of medicated leaven, 20-40 parts of fried hawthorn, 15-45 parts of alpinia katsumadai, 20-50 parts of fried sophora japonica, 15-35 parts of codonopsis pilosula, 15-55 parts of compound of glauber-salt and liquorice, 15-35 parts of realgar, 15-35 parts of polygonum cuspidatum, 15-35 parts of rhizoma cimicifugae, 15-35 parts of cinnabar and 25-65 parts of talc. The traditional Chinese medicinal composition has the beneficial effects of reasonable formula, simple preparation, no toxic or side effect, no pollution, no drug residue, no drug resistance, superfine grinding, high bioavailability and remarkable curative effect, and has a special effect in treating porcine viral diarrhea by virtue of clinical verification.

Description

Chinese medicine composition for the treatment of pig virus diarrhoea and preparation method thereof
Technical field
The present invention relates to Chinese medicine composition for the treatment of pig virus diarrhoea and preparation method thereof, belong to animal field of medicaments, particularly a kind of Chinese medicine composition that is specifically designed to treatment pig virus diarrhoea and preparation method thereof.
Background technology
Pig virus diarrhoea mainly comprises the three large spreading venereal diseases toxicity diseases such as transmissible gastroenteritis of swine, epidemic diarrhea and porcine rotavirus disease.Wherein transmissible gastroenteritis of swine is that the one that caused by transmissible gastro-enteritis virus is acute, height contagious disease, the pig of all ages and classes and kind all can infect, mainly take the piglet vomiting in 2 week age, severe diarrhea, dehydration and in 1 week age the high case fatality rate of piglet (common 100%) as feature.The epidemic diarrhea of pig is a kind of infectious intestinal disease being caused by Porcine epidemic diarrhea virus, and feature is vomiting, diarrhoea and dehydration, each age pig can infection morbidity, sickness rate can reach 100%.Porcine rotavirus disease is the acute infectious intestinal disease of the pig that caused by porcine rotavirus, the cardinal symptom of piglet is anorexia, vomiting, dysentery, middle pig and large pig are inapparent infection, there is no symptom, sickness rate is up to 80~100%, mostly morbidity pig is 8 weeks piglets below age, and the less sickness rate of age in days is higher, and case fatality rate is generally in 30%.Primary disease all can occur throughout the year, is one of principal disease of harm pig industry.
This disease almost spreads all over all countries of raising pigs of the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antiviral Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And various antiviral agents ban use of as the Ministry of Agriculture such as ribavirin, amantadine.
Therefore research and develop a kind of drug residue free for the treatment of pig virus diarrhoea, the specific medicament producing that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the Chinese medicine composition of effective treatment pig virus diarrhoea of drug residue and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of Chinese medicine composition for the treatment of pig virus diarrhoea, by following component by weight mixed preparing form: Indigo Naturalis 15-35 part, Massa Medicata Fermentata 20-40 part, Fructus Crataegi (parched) 20-40 part, Semen Alpiniae Katsumadai 15-45 part, Flos Sophorae (parched) 20-50 part, Radix Codonopsis 15-35 part, Matrii Sulfas Exsiccatus 15-55 part, Realgar 15-35 part, Rhizoma Polygoni Cuspidati 15-35 part, Rhizoma Cimicifugae 15-35 part, Cinnabaris 15-35 part, Talcum 25-65 part.
Described various component optimum ratio amount is: 25 parts of Indigo Naturaliss, 30 parts of Massa Medicata Fermentatas, 30 parts of Fructus Crataegi (parched), 30 parts of Semen Alpiniae Katsumadai, 35 parts of Flos Sophorae (parched), 25 parts of Radix Codonopsis, 35 parts of Matrii Sulfas Exsiccatus, 25 parts of Realgars, 25 parts of Rhizoma Polygoni Cuspidati, 25 parts of Rhizoma Cimicifugaes, 25 parts, Cinnabaris, 45 parts, Talcum.
Treat a preparation method for the Chinese medicine composition of pig virus diarrhoea, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Indigo Naturalis 15-35 part, Massa Medicata Fermentata 20-40 part, Fructus Crataegi (parched) 20-40 part, Semen Alpiniae Katsumadai 15-45 part, Flos Sophorae (parched) 20-50 part, Radix Codonopsis 15-35 part, mix 5-10 minute to even;
(3) take by weight Matrii Sulfas Exsiccatus 15-55 part, Realgar 15-35 part, Rhizoma Polygoni Cuspidati 15-35 part, Rhizoma Cimicifugae 15-35 part, Cinnabaris 15-35 part, Talcum 25-65 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Indigo Naturalis: become, tremble with fear, return Liver Channel, there is the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly that pyretic toxicity is sent out speckle, heat in blood is told nosebleed, hot carbuncle sore, laryngopharynx swelling and pain, aphtha of the mouth and tongue etc.
Massa Medicata Fermentata: sweet, pungent, warm, return spleen, stomach warp, the function that there is invigorating the spleen and regulating the stomach, helps digestion in adjusting; Cure mainly retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery etc.
Fructus Crataegi (parched): sweet, sour, warm, return spleen, stomach, Liver Channel, there is the function of promoting digestion and removing stagnation, circulation of qi promoting dissipating blood stasis; Cure mainly dyspeptic abdominal flatulence, dyspepsia etc.
Semen Alpiniae Katsumadai: pungent, warm, return spleen, stomach warp, there is function drying damp and strengthening spleen, stomach warming preventing or arresting vomiting; Cure mainly that Deficiency and coldness of spleen and stomach, cold type of pain, cold-damp are had loose bowels, vomiting etc.
Flos Sophorae (parched): bitter, be slightly cold, return large intestine, Liver Channel, there is the function of cooling blood for hemostasis, purging liver-fire; Cure mainly have blood in stool, dysentery, metrorrhagia, liver-heat conjunctival congestion etc.
Radix Codonopsis: sweet, flat, return lung, spleen channel, there is the function of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; Cure mainly that weakness of the spleen and stomach, few food diarrhoea, the deficiency of the lung are breathed with cough, fatigue and lack of strength, the deficiency of vital energy hang down de-etc.
Matrii Sulfas Exsiccatus: bitter, one-tenth, cold, return large intestine, stomach warp, the function that there is purging heat to relax the bowels, moistening for dryness and softening hard mass, relieves inflammation or internal heat and subside a swelling; Cure mainly excess-heat constipation, constipated, the stagnant stomachache of feces, laryngopharynx swelling and pain, aphtha of the mouth and tongue, conjunctival congestion, carbuncle etc.
Realgar: pungent, warm, return lung, spleen, stomach, large intestine channel, there is the function of removing toxic substances parasite killing, removing dampness and eliminating phlegm; Cure mainly carbuncle sore tumefacting virus, abdominal pain due to worm stagnation, infantile convulsion, snake bite and insect sting, scabies etc.
Rhizoma Polygoni Cuspidati: micro-hardship, be slightly cold, return lung, liver, gallbladder meridian, there is the function of dampness removing jaundice eliminating, heat-clearing and toxic substances removing, the analgesic therapy of invigorating blood circulation, relieving cough and resolving phlegm; Cure mainly jaundice due to damp-heat, puerperal blood stasis, stranguria with turbid discharge, rheumatic arthralgia, carbuncle sore tumefacting virus, burn and scald, traumatic injury, cough due to lung-heat, enteritis etc.
Rhizoma Cimicifugae: pungent, micro-sweet, be slightly cold, return lung, spleen, stomach, large intestine channel, there is the function of the rash delivered, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy; Curing mainly varioliform exanthema thoroughly sends out smooth, laryngopharynx swelling and pain, chronic diarrhea, proctoptosis, uterus and hangs down de-etc.
Cinnabaris: sweet, be slightly cold, GUIXIN warp, has the function relieving convulsion, that calm the nerves, detoxify that clears away heart-fire; Cure mainly heat in the heart ailment said due to cold or exposure, restlessness, calentura epilepsy, brain Huang, sore swollen toxin etc.
Talcum: sweet, light, cold, return lung, bladder, stomach warp, there is the function of inducing diuresis for treating stranguria syndrome, clearing away summer-heat; Cure mainly pyretic stranguria, stranguria caused by urinary stone, diarrhea due to damp-heat, summer-heat, eczema, eczema etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for pathogenic microorganism and the clinical symptoms of pig virus diarrhoea, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this 12 taste Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, treatment pig virus diarrhoea is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of Chinese medicine composition for the treatment of pig virus diarrhoea and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of Indigo Naturaliss, 200 parts of Massa Medicata Fermentatas, 200 parts of Fructus Crataegi (parched), 150 parts of Semen Alpiniae Katsumadai, 200 parts of Flos Sophorae (parched), 150 parts of Radix Codonopsis, mix 5-10 minute to even;
(3) take by weight 150 parts of Matrii Sulfas Exsiccatus, 150 parts of Realgars, 150 parts of Rhizoma Polygoni Cuspidati, 150 parts of Rhizoma Cimicifugaes, 150 parts, Cinnabaris, 250 parts, Talcum, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of Chinese medicine composition for the treatment of pig virus diarrhoea and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of Indigo Naturaliss, 300 parts of Massa Medicata Fermentatas, 300 parts of Fructus Crataegi (parched), 300 parts of Semen Alpiniae Katsumadai, 350 parts of Flos Sophorae (parched), 250 parts of Radix Codonopsis, mix 5-10 minute to even;
(3) take by weight 350 parts of Matrii Sulfas Exsiccatus, 250 parts of Realgars, 250 parts of Rhizoma Polygoni Cuspidati, 250 parts of Rhizoma Cimicifugaes, 250 parts, Cinnabaris, 450 parts, Talcum, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of Chinese medicine composition for the treatment of pig virus diarrhoea and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of Indigo Naturaliss, 400 parts of Massa Medicata Fermentatas, 400 parts of Fructus Crataegi (parched), 450 parts of Semen Alpiniae Katsumadai, 500 parts of Flos Sophorae (parched), 350 parts of Radix Codonopsis, mix 5-10 minute to even;
(3) take by weight 550 parts of Matrii Sulfas Exsiccatus, 350 parts of Realgars, 350 parts of Rhizoma Polygoni Cuspidati, 350 parts of Rhizoma Cimicifugaes, 350 parts, Cinnabaris, 650 parts, Talcum, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
Clinical experiment animal is selected 120-130 age in days, the ill pig that Laboratory Diagnosed is epidemic diarrhea.Ill pig isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experiment is carried out 8 days altogether; Blank group is left intact, and medicine matched group uses treatment by institute's control drug by its description; Chinese medicine composition group of the present invention can be by product of the present invention (the prepared compositions of the embodiment of the present invention 2) the ill pig of feeding etc., and a day dose is: feed by the every 100g spice of the present invention 160kg, every day 2-3 time, be used in conjunction 3-5 day; After oral, reach the object for the treatment of disease by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Result when following table is experiment end.
Efficacy assessment standard:
Cure: spirit is normal, the clinical symptom disappearance such as it is normal to drink water, and feces is normal of searching for food, detect and have no Porcine epidemic diarrhea virus etc. through laboratory experiment in swine excrement.
When end, there is symptom: clinical symptoms is not improved even and increased the weight of.
Table is the field applicable cases contrast of the present invention and other medicines treatment porcine epizootic diarrhea:
Numbering Group Mortality rate % Cure rate % When end, there is symptom rate %
I Blank group 23.3 0 76.7
II The pig dysentery health group of faling apart 10 70 20
III Present composition group 6.7 80 13.3
This clinical effectiveness statistical analysis, the loose group of present composition treatment group and pig dysentery health extremely significantly (P < 0.01) of difference compared with aspect cure rate.
Safety testing:
Choose 10 of 90 age in days health pig, 5 times of spices according to the made compositions recommended dose of the embodiment of the present invention 2 are fed 10 days, during medication, health pig is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
The above-mentioned detailed description that Chinese medicine composition to this treatment pig virus diarrhoea and preparation method thereof carries out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. treat a Chinese medicine composition for pig virus diarrhoea, it is characterized in that by following component by weight mixed preparing form: Indigo Naturalis 15-35 part, Massa Medicata Fermentata 20-40 part, Fructus Crataegi (parched) 20-40 part, Semen Alpiniae Katsumadai 15-45 part, Flos Sophorae (parched) 20-50 part, Radix Codonopsis 15-35 part, Matrii Sulfas Exsiccatus 15-55 part, Realgar 15-35 part, Rhizoma Polygoni Cuspidati 15-35 part, Rhizoma Cimicifugae 15-35 part, Cinnabaris 15-35 part, Talcum 25-65 part form.
2. the Chinese medicine composition for the treatment of pig virus diarrhoea according to claim 1, is characterized in that described various component optimum ratio amount is: 25 parts of Indigo Naturaliss, 30 parts of Massa Medicata Fermentatas, 30 parts of Fructus Crataegi (parched), 30 parts of Semen Alpiniae Katsumadai, 35 parts of Flos Sophorae (parched), 25 parts of Radix Codonopsis, 35 parts of Matrii Sulfas Exsiccatus, 25 parts of Realgars, 25 parts of Rhizoma Polygoni Cuspidati, 25 parts of Rhizoma Cimicifugaes, 25 parts, Cinnabaris, 45 parts of compositions of Talcum.
3. a preparation method for the Chinese medicine composition for the treatment of pig virus diarrhoea according to claim 1 and 2, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Indigo Naturalis 15-35 part, Massa Medicata Fermentata 20-40 part, Fructus Crataegi (parched) 20-40 part, Semen Alpiniae Katsumadai 15-45 part, Flos Sophorae (parched) 20-50 part, Radix Codonopsis 15-35 part, mix 5-10 minute to even;
(3) take by weight Matrii Sulfas Exsiccatus 15-55 part, Realgar 15-35 part, Rhizoma Polygoni Cuspidati 15-35 part, Rhizoma Cimicifugae 15-35 part, Cinnabaris 15-35 part, Talcum 25-65 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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CN108261485A (en) * 2016-12-31 2018-07-10 天津瑞贝特科技发展有限公司 Treat Chinese medicine composition of pig virus diarrhoea and preparation method thereof

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