CN102727693B - Compound propolis composition used for treating swine toxoplasmosis, and preparation method thereof - Google Patents

Compound propolis composition used for treating swine toxoplasmosis, and preparation method thereof Download PDF

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Publication number
CN102727693B
CN102727693B CN201210204210.3A CN201210204210A CN102727693B CN 102727693 B CN102727693 B CN 102727693B CN 201210204210 A CN201210204210 A CN 201210204210A CN 102727693 B CN102727693 B CN 102727693B
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parts
radix
composition
propolis
swine toxoplasmosis
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CN201210204210.3A
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CN102727693A (en
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周庆福
刘文利
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Qingdao Lvman Bioengineering Co Ltd
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Qingdao Lvman Bioengineering Co Ltd
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Abstract

The invention relates to a compound propolis composition used for treating swine toxoplasmosis. The composition is prepared from mixed components of, by weight: 15-35 parts of propolis, 15-40 parts of antifebrile dichroa root, 15-45 parts of betelnutpalm seed, 15-35 parts of tangerine peel, 15-35 parts of Chinese thorowax root, 15-35 parts of balloonflower root, 15-45 parts of male fern rhizome, 15-35 parts of Chinese ephedra herb, 15-35 parts of epimedium, and 15-40 parts of licorice root. The composition provided by the invention is advantaged in reasonable formula, simple preparation, pure traditional Chinese composition and no pollution, no toxic or side effect, no drug residue, and substantial curative effect. As a result of clinical application, the composition has a special effect in treating swine toxoplasmosis.

Description

Compound bee-glue composition for the treatment of swine toxoplasmosis and preparation method thereof
Technical field
The present invention relates to a kind of compound bee-glue composition for the treatment of swine toxoplasmosis and preparation method thereof, belong to the animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to the treatment swine toxoplasmosis and preparation method thereof.
Background technology
Swine toxoplasmosis is called again tokoplasmosis or toxoplasmosis, is to be caused the protozoacide of infecting both domestic animals and human by the Toxoplasmosis animal and human.It is principal character that primary disease be take high heat, breathing and neurological symptom, animal dead and pregnant animal miscarriage, stillborn fetus, fetal anomaly.
At present, this disease does not also have good Therapeutic Method, only has sulfa drugs that specially good effect is arranged, and other antibiotic are invalid, once produce drug resistance, this disease is difficult to treatment; And also have drug residue, affect health.This disease is to pig industry and people are healthy causes very large threat.
Therefore research and develop a kind of treat swine toxoplasmosis and have no side effect, drug residue free, the specific medicament produced that has no drug resistance be one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, have no side effect, have no drug resistance generation, drug residue free, successful, effectively treat compound bee-glue composition of swine toxoplasmosis and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of swine toxoplasmosis, by following component by weight mixed preparing form: propolis 15-35 part, Radix Dichroae 15-40 part, Semen Arecae 15-45 part, Pericarpium Citri Reticulatae 15-35 part, Radix Bupleuri 15-35 part, Radix Platycodonis 15-35 part, Rhizoma Dryopteris Crassirhizomatis 15-45 part, Herba Ephedrae 15-35 part, Herba Epimedii 15-35 part, Radix Glycyrrhizae 15-40 part.
Described various component optimum ratio amount is: 25 parts of propolis, 30 parts of Radix Dichroaes, 30 parts of Semen Arecaes, 25 parts of Pericarpium Citri Reticulataes, 25 parts of Radix Bupleuri, 25 parts of Radix Platycodoniss, 30 parts of Rhizoma Dryopteris Crassirhizomatiss, 25 parts, Herba Ephedrae, 25 parts of Herba Epimedii, 30 parts, Radix Glycyrrhizae.
A kind of preparation method for the treatment of the compound bee-glue composition of swine toxoplasmosis, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Radix Dichroae 15-40 part, Semen Arecae 15-45 part, Pericarpium Citri Reticulatae 15-35 part, Radix Bupleuri 15-35 part, mix 5-10 minute to even;
(3) take by weight Radix Platycodonis 15-35 part, Rhizoma Dryopteris Crassirhizomatis 15-45 part, Herba Ephedrae 15-35 part, Herba Epimedii 15-35 part, Radix Glycyrrhizae 15-40 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, return spleen, lung, stomach warp, there is anti-bacteria and anti-virus, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic oxidation, stop blooding, moisturize, the function of relieving cough and asthma, protection gastrointestinal mucosa.
Radix Dichroae: bitter, acrid, cold, return lung, liver, heart channel, there is the function of parasite killing, expectorant removing food stagnancy; Curing mainly protozoacide, the impaction of rumen, phlegm retention gathers etc.
Semen Arecae: bitter, hot, warm, return stomach, large intestine channel, there is the function of anthelmintic, removing food stagnancy, circulation of qi promoting, diuretic; Cure mainly taeniasis, the impaction of rumen, dyspeptic abdominal distention, constipation, edema etc.
Pericarpium Citri Reticulatae: bitter, hot, warm, return lung, spleen channel, there is the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, stomachache, tripe is swollen, have loose bowels, productive cough due to phlegm-damp etc.
Radix Bupleuri: hot, bitter, be slightly cold, return liver, gallbladder, lung meridian, there is the function of delivering with inner, elevate a turnable ladder yang-energy, dispersing the stagnated live-QI to relieve the stagnation of QI; Cure mainly cold, fever, alternate attack of chill and fever, insufficiency of the spleen chronic diarrhea, proctoptosis etc.
Radix Platycodonis: bitter, hot, flat, return lung meridian, there is lung qi dispersing, eliminate the phlegm, the function of sore-throat relieving, evacuation of pus; Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess etc.
Rhizoma Dryopteris Crassirhizomatis: bitter, cold, return liver, stomach warp, there is the function of heat-clearing and toxic substances removing, cooling blood for hemostasis, anthelmintic; Cure mainly epidemic disease flu, maculae caused by violent heat pathogen, sore swollen toxin, abdominal pain due to worm stagnation etc.
Herba Ephedrae: bitter, hot, warm, return lung, urinary bladder channel, there is the function of the cold expelling that induces sweat, depressed lung-energy dispersing, inducing diuresis to remove edema; Cure mainly cough, affection of exogenous wind-cold, asthma, edema etc.
Herba Epimedii: sweet, hot, warm, return liver, kidney channel, there is the function of kidney-replenishing, bone and muscle strengthening, wind-damp dispelling; Cure mainly that the waist hip is unable, rheumatic arthralgia etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Above all flavor Chinese medicine, according to the tcm theory compatible combination, for paathogenic factor and the pathological change of swine toxoplasmosis, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition is pollution-free, no drug residue, and cost is low, draws materials wide, the curative effect highly significant.According to the tradition Chinese veterinarian of motherland, theoretical and modern Chinese medicine pharmacology theory, optimize this ten kinds of medicines, and make them according to optimum ratio, form pure Chinese powder medicine, and clinical practice proves to the treatment swine toxoplasmosis is had specially good effect and has no side effect and drug resistance.And make livestock products reach nuisanceless requirement, meet the export standard of poultry product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of compound bee-glue composition for the treatment of swine toxoplasmosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of propolis, 150 parts of Radix Dichroaes, 150 parts of Semen Arecaes, 150 parts of Pericarpium Citri Reticulataes, 150 parts of Radix Bupleuri, mix 5-10 minute to even;
(3) take by weight 150 parts of Radix Platycodoniss, 150 parts of Rhizoma Dryopteris Crassirhizomatiss, 150 parts, Herba Ephedrae, 150 parts of Herba Epimedii, 150 parts, Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of swine toxoplasmosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of propolis, 200 parts of Radix Dichroaes, 300 parts of Semen Arecaes, 250 parts of Pericarpium Citri Reticulataes, 250 parts of Radix Bupleuri, mix 5-10 minute to even;
(3) take by weight 250 parts of Radix Platycodoniss, 300 parts of Rhizoma Dryopteris Crassirhizomatiss, 250 parts, Herba Ephedrae, 250 parts of Herba Epimedii, 300 parts, Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of swine toxoplasmosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of propolis, 400 parts of Radix Dichroaes, 450 parts of Semen Arecaes, 350 parts of Pericarpium Citri Reticulataes, 350 parts of Radix Bupleuri, mix 5-10 minute to even;
(3) take by weight 350 parts of Radix Platycodoniss, 450 parts of Rhizoma Dryopteris Crassirhizomatiss, 350 parts, Herba Ephedrae, 350 parts of Herba Epimedii, 400 parts, Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
The clinical experiment animal selects 70-85 age in days, body weight at 25kg-35kg, the ill pig that Laboratory Diagnosed is swine toxoplasmosis.Ill pig isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experiment is carried out 7 days altogether; The blank group is left intact, and the medicine matched group is used treatment with " bow that goes out is loose " by specification; Chinese medicine composition group of the present invention can be by the ill pig of product feeding of the present invention, and a day dose is: 230 kilograms of every 100 gram present composition spices are fed, every day 1-2 time; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result (testing the 7th day) when following table is the experiment end.
Table is the situation contrast of the present invention and other medicines treatment swine toxoplasmosis:
Numbering Group Mortality rate % Cure rate % Symptom rate % is arranged during end
I The blank group 10.0 63.3 26.7
II The loose group of the bow that goes out 6.7 83.3 10.0
III Chinese medicine composition group of the present invention 3.3 90.0 6.7
This clinical effectiveness statistical analysis, present composition group is being compared significant difference (P<0.05) with the loose group of the bow that goes out aspect cure rate.
Safety testing:
Choose 10 of 70 age in days health pig, 5 times of spices according to the made compositions recommended dose of the embodiment of the present invention 1 are fed 10 days, during medication, health pig is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of compound bee-glue composition of this treatment swine toxoplasmosis and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. a compound bee-glue composition for the treatment of swine toxoplasmosis, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Radix Dichroae 15-40 part, Semen Arecae 15-45 part, Pericarpium Citri Reticulatae 15-35 part, Radix Bupleuri 15-35 part, Radix Platycodonis 15-35 part, Rhizoma Dryopteris Crassirhizomatis 15-45 part, Herba Ephedrae 15-35 part, Herba Epimedii 15-35 part, Radix Glycyrrhizae 15-40 part.
2. the compound bee-glue composition for the treatment of swine toxoplasmosis according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 30 parts of Radix Dichroaes, 30 parts of Semen Arecaes, 25 parts of Pericarpium Citri Reticulataes, 25 parts of Radix Bupleuri, 25 parts of Radix Platycodoniss, 30 parts of Rhizoma Dryopteris Crassirhizomatiss, 25 parts, Herba Ephedrae, 25 parts of Herba Epimedii, 30 parts, Radix Glycyrrhizae.
3. the preparation method of the compound bee-glue composition of a treatment swine toxoplasmosis according to claim 1 is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Radix Dichroae 15-40 part, Semen Arecae 15-45 part, Pericarpium Citri Reticulatae 15-35 part, Radix Bupleuri 15-35 part, mix 5-10 minute to even;
(3) take by weight Radix Platycodonis 15-35 part, Rhizoma Dryopteris Crassirhizomatis 15-45 part, Herba Ephedrae 15-35 part, Herba Epimedii 15-35 part, Radix Glycyrrhizae 15-40 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
CN201210204210.3A 2012-06-20 2012-06-20 Compound propolis composition used for treating swine toxoplasmosis, and preparation method thereof Expired - Fee Related CN102727693B (en)

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Publication number Priority date Publication date Assignee Title
CN104645172A (en) * 2013-11-20 2015-05-27 天津嘉瑞生物科技有限公司 Traditional Chinese composition for treating porcine toxoplasmosis and preparation method thereof
CN104474416A (en) * 2014-11-03 2015-04-01 青岛绿曼生物工程有限公司 Swine toxoplasmosis treatment compound propolis composition and preparation method thereof
CN105535051A (en) * 2016-03-02 2016-05-04 江西傲新生物科技有限公司 Pharmaceutical preparation for preventing and treating toxoplasmosis of pigs and preparation method of pharmaceutical preparation

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CN101647515A (en) * 2009-06-26 2010-02-17 郑州后羿制药有限公司 Chinese herbal growth promoter, preparation method and application thereof

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张志远等.《中药抗动物寄生虫病得研究进展》.《河南畜牧兽医》.2001,第22卷(第8期),10-11.
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