CN102600285B - Complex propolis composition for treating infectious atrophic rhinitis of pigs and preparation method thereof - Google Patents
Complex propolis composition for treating infectious atrophic rhinitis of pigs and preparation method thereof Download PDFInfo
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- CN102600285B CN102600285B CN201110434285.6A CN201110434285A CN102600285B CN 102600285 B CN102600285 B CN 102600285B CN 201110434285 A CN201110434285 A CN 201110434285A CN 102600285 B CN102600285 B CN 102600285B
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Abstract
The invention relates to a complex propolis composition for treating infectious atrophic rhinitis of pigs and a preparation method thereof, and relates to the animal medicine field. The preparation method comprises the following steps that (1) each ingredient in a prescription is respectively micro-smashed to pass through a 700-mesh sieve; (2) 15 to 35 parts of propolis, 15 to 35 parts of angelica, 15 to 35 parts of rhizoma ligustici wallichii, 15 to 35 parts of radix paeoniae alba and 15 to 45 parts of radix scutellariae are measured by weight and are blended for 5 to 10 minutes until being uniformly blended; (3) 15 to 35 parts of phellodendron, 15 to 40 parts of yellowweed, 15 to 45 parts of fructus forsythiae, 15 to 45 parts of liquorice and 15 to 45 parts of radix aconiti preparata are measured by weight and are blended for 5 to 10 minutes until being uniformly blended; and (4) compositions respectively prepared in steps (2) and (3) are mixed to be continuously blended for 10 to 15 minutes until being uniformly blended. The complex propolis composition has beneficial effects that the prescription is reasonable, simplicity in preparation is realized, and the composition is toxic-free, has no side effect and is free from pollution, medicinal residue and drug resistance. Being micro-smashed, the biological availability is high, the curative effect is very remarkable, and a specially good effect on treating infectious atrophic rhinitis of the pigs is clinically proved.
Description
Technical field
The present invention relates to animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment pig infectious atrophic rhinitis and preparation method thereof.
Background technology
Pig infectious atrophic rhinitis is the universal pandemic serious contact upper respiratory infectious disease of one being caused by pig toxigenicity pasteurella multocida and bronchus deteriorated blood bordetella bacilli, clinically taking the distortion of sneeze, nasal bone, turbinates atrophy or disappearance and deviation of nasal septum as feature.The pig of various ages and kind all can occur, and case fatality rate is all between 2%-10%, and infected pigs can cause serious feed consumption to increase, deliver for sale delay etc.Primary disease all can occur throughout the year, is one of principal disease of serious harm pig industry.
This disease almost spreads all over all countries of raising pigs of the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug is because life-time service has drug residue and easily produces drug resistance, and worse and worse, and drug residue causes exporting limited and harm people are healthy for its clinical effectiveness, thereby the use of antimicrobial drug is very restricted.
Therefore research and develop a kind of drug residue free for the treatment of pig infectious atrophic rhinitis, the specific medicament producing that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the compound bee-glue composition of effective treatment pig infectious atrophic rhinitis of drug residue and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of pig infectious atrophic rhinitis, by following component by weight mixed preparing form: propolis 15-35 part, Radix Angelicae Sinensis 15-35 part, Rhizoma Chuanxiong 15-35 part, Radix Paeoniae Alba 15-35 part, Radix Scutellariae 15-45 part, Cortex Phellodendri 15-35 part, Herba Senecionis Scandentis 15-40 part, Fructus Forsythiae 15-45 part, Radix Glycyrrhizae 15-45 part, Radix Aconiti Preparata 15-45 part.
On the basis of such scheme, described various component optimum ratio amounts are: 25 parts of propolis, 25 parts of Radix Angelicae Sinensis, 25 parts of Rhizoma Chuanxiongs, 25 parts of the Radix Paeoniae Albas, 30 parts of Radix Scutellariaes, 25 parts of Cortex Phellodendris, 25 parts of Herba Senecionis Scandentiss, 30 parts of Fructus Forsythiaes, 30 parts, Radix Glycyrrhizae, 30 parts of Radix Aconiti Preparatas.
Treat a preparation method for the compound bee-glue composition of pig infectious atrophic rhinitis, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Radix Angelicae Sinensis 15-35 part, Rhizoma Chuanxiong 15-35 part, Radix Paeoniae Alba 15-35 part, Radix Scutellariae 15-45 part, mix 5-10 minute to even;
(3) take by weight Cortex Phellodendri 15-35 part, Herba Senecionis Scandentis 15-40 part, Fructus Forsythiae 15-45 part, Radix Glycyrrhizae 15-45 part, Radix Aconiti Preparata 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, return spleen, stomach warp, the function that there is anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic is oxidized, stops blooding, protects gastrointestinal mucosa.
Radix Angelicae Sinensis: sweet, pungent, warm, return liver, the heart, spleen channel, there is the function of blood-supplementing blood-nourishing, promoting blood circulation and stopping pain, moistening dryness for relaxing bowels; Cure mainly blood deficiency impairment caused by overstrain, blood stasis pain, too fat to move skin infection etc.
Fructus Forsythiae: bitter, cold, return lung, the heart, small intestine meridian, there is the function of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Cure mainly epidemic febrile disease heating, skin ulcer general edema with yellowish skin poison etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Cortex Phellodendri: bitter, cold, return kidney, urinary bladder channel, there is the function of heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever; Cure mainly damp-heat dysentery, jaundice, pyretic stranguria, sore swollen toxin, eczema, hyperactivity of fire caused by deficiency of YIN etc.
The Radix Paeoniae Alba: bitter, acid, be slightly cold, return spleen, Liver Channel, there is suppressing the hyperactive liver pain relieving, the function of the yin fluid astringing that nourishes blood; Cure mainly deficiecny of liver-YIN, deficiency-heat, dysentery stomachache, spasm of the limbs etc.
Radix Scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, there is heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive function; Cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, high heat are greedyly drunk, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus etc.
Rhizoma Chuanxiong: pungent, warm, return gallbladder, liver, pericardium channel, there is the function of blood-activating and qi-promoting, wind-expelling pain-stopping; Cure mainly traumatic injury, stagnation of QI-blood, puerperal blood stasis, rheumatic arthralgia etc.
Herba Senecionis Scandentis: bitter, cold, return lung, Liver Channel, there is the function of heat-clearing and toxic substances removing, liver heat removing and eyesight improving, dampness removing; Cure mainly anemopyretic cold, conjunctival congestion and swelling pain, damp-heat diarrhea, damp-heat in the urinary bladder, the yellow furunculosis of skin ulcer etc.
Radix Aconiti Preparata: bitter, pungent, hot, GUIXIN, liver,kidney,spleen warp, have the function of expelling wind and removing dampness, antalgic; Cure mainly anemofrigid-damp arthralgia, colic of cold type stomachache, arthralgia etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for pathogenic microorganism, clinical symptoms and the pathological change of pig infectious atrophic rhinitis, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Ten Herbs, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, treatment pig infectious atrophic rhinitis is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively ensured that people's is healthy.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of compound bee-glue composition for the treatment of pig infectious atrophic rhinitis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of propolis, 150 parts of Radix Angelicae Sinensis, 150 parts of Rhizoma Chuanxiongs, 150 parts of the Radix Paeoniae Albas, 150 parts of Radix Scutellariaes, mix 5-10 minute to even;
(3) take by weight 150 parts of Cortex Phellodendris, 150 parts of Herba Senecionis Scandentiss, 150 parts of Fructus Forsythiaes, 150 parts, Radix Glycyrrhizae, 150 parts of Radix Aconiti Preparatas, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of pig infectious atrophic rhinitis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of propolis, 250 parts of Radix Angelicae Sinensis, 250 parts of Rhizoma Chuanxiongs, 250 parts of the Radix Paeoniae Albas, 300 parts of Radix Scutellariaes, mix 5-10 minute to even;
(3) take by weight 250 parts of Cortex Phellodendris, 250 parts of Herba Senecionis Scandentiss, 300 parts of Fructus Forsythiaes, 300 parts, Radix Glycyrrhizae, 300 parts of Radix Aconiti Preparatas, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of pig infectious atrophic rhinitis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of propolis, 350 parts of Radix Angelicae Sinensis, 350 parts of Rhizoma Chuanxiongs, 350 parts of the Radix Paeoniae Albas, 450 parts of Radix Scutellariaes, mix 5-10 minute to even;
(3) take by weight 350 parts of Cortex Phellodendris, 400 parts of Herba Senecionis Scandentiss, 450 parts of Fructus Forsythiaes, 450 parts, Radix Glycyrrhizae, 450 parts of Radix Aconiti Preparatas, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
By the ill pig of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 230kg feeds, and the 430kg that drinks water, every day 2-3 time, is used in conjunction 3-5 day; After oral, reach the object for the treatment of disease by gastrointestinal absorption.
Table is the field applicable cases contrast of the present invention and other medicines treatment pig infectious atrophic rhinitis:
| Numbering | Group | Case fatality rate % | Cure rate % | When end, there is symptom rate % |
| I | Blank group | 8.5 | 64.0 | 27.5 |
| II | The pig BIYANKANG group of faling apart | 5.7 | 81.5 | 12.8 |
| III | Present composition group | 3.2 | 91.7 | 5.1 |
This clinical effectiveness statistical analysis, the loose group of present composition treatment group and pig BIYANKANG extremely significantly (P < 0.01) of difference compared with aspect cure rate.
The above-mentioned detailed description that compound bee-glue composition to this treatment pig infectious atrophic rhinitis and preparation method thereof carries out with reference to embodiment; illustrative instead of determinate; can list several embodiment according to institute's limited range; therefore in the variation and the amendment that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a compound bee-glue composition for pig infectious atrophic rhinitis, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Radix Angelicae Sinensis 15-35 part, Rhizoma Chuanxiong 15-35 part, Radix Paeoniae Alba 15-35 part, Radix Scutellariae 15-45 part, Cortex Phellodendri 15-35 part, Herba Senecionis Scandentis 15-40 part, Fructus Forsythiae 15-45 part, Radix Glycyrrhizae 15-45 part, Radix Aconiti Preparata 15-45 part.
2. a kind of compound bee-glue composition for the treatment of pig infectious atrophic rhinitis according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of Radix Angelicae Sinensis, 25 parts of Rhizoma Chuanxiongs, 25 parts of the Radix Paeoniae Albas, 30 parts of Radix Scutellariaes, 25 parts of Cortex Phellodendris, 25 parts of Herba Senecionis Scandentiss, 30 parts of Fructus Forsythiaes, 30 parts, Radix Glycyrrhizae, 30 parts of Radix Aconiti Preparatas.
3. a preparation method for the compound bee-glue composition for the treatment of pig infectious atrophic rhinitis according to claim 1, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Radix Angelicae Sinensis 15-35 part, Rhizoma Chuanxiong 15-35 part, Radix Paeoniae Alba 15-35 part, Radix Scutellariae 15-45 part, mix 5-10 minute to even;
(3) take by weight Cortex Phellodendri 15-35 part, Herba Senecionis Scandentis 15-40 part, Fructus Forsythiae 15-45 part, Radix Glycyrrhizae 15-45 part, Radix Aconiti Preparata 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110434285.6A CN102600285B (en) | 2011-12-22 | 2011-12-22 | Complex propolis composition for treating infectious atrophic rhinitis of pigs and preparation method thereof |
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| CN201110434285.6A CN102600285B (en) | 2011-12-22 | 2011-12-22 | Complex propolis composition for treating infectious atrophic rhinitis of pigs and preparation method thereof |
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| CN102600285A CN102600285A (en) | 2012-07-25 |
| CN102600285B true CN102600285B (en) | 2014-06-18 |
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| CN1279995A (en) * | 1999-07-09 | 2001-01-17 | 翟广君 | Chinese medicine composition for curing rhinitis |
| CN1957997A (en) * | 2005-10-31 | 2007-05-09 | 天津市润拓生物技术有限公司 | Animal use compound medicament with effects of relieving the muscles and skin, clearing away heat, relieving darrhea, and relieving dysentery, and preparation method |
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