CN102370972B - Compound Chinese medicine composition for treating infectious bronchitis of chicken and preparation method thereof - Google Patents
Compound Chinese medicine composition for treating infectious bronchitis of chicken and preparation method thereof Download PDFInfo
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- CN102370972B CN102370972B CN201110306912.8A CN201110306912A CN102370972B CN 102370972 B CN102370972 B CN 102370972B CN 201110306912 A CN201110306912 A CN 201110306912A CN 102370972 B CN102370972 B CN 102370972B
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Abstract
The invention discloses a compound Chinese medicine composition for treating infectious bronchitis of chicken and a preparation method thereof, and relates to poultry medicine and the preparation field thereof. The invention aims to provide a compound Chinese medicine composition for treating infectious bronchitis of chicken, which has reasonable formula and is simple to prepare, and a preparation method thereof. The compound Chinese medicine composition comprises the following specific ingredients. The preparation method comprises the following steps: (1) carrying out ultramicro smashing on various ingredients (except interferon) in a formula, and screening by a screen of 700 meshes; (2) weighing 15-25 parts of propolis, 5-15 parts of interferon for chicken, 10-35 parts of folium isatidis and 15-30 parts of ephedra according to weight, and evenly mixing for 5-10 minutes; (3) weighing 10-30 parts of Scutellaria baicalensis, 10-35 parts of Platycodon grandiflorum and 15-35 parts of liquorice according to weight, and evenly mixing for 5-10 minutes; (4) combining composites obtained in steps (2) and (3); and evenly mixing for 10-15 minutes. The compound Chinese medicine composition has the beneficial effect that the compound Chinese medicine composition is simple to prepare, does not have toxic and side effect, is free from pollution and drug residue, does not have drug tolerance, has the advantages of ultramicro smashing, high bioavailability and obvious curative effect and has specially good effect on treating the infectious bronchitis of chicken.
Description
Technical field
The present invention relates to fowl medicine and preparation method thereof field, particularly a kind of herbal mixture composition and method of making the same for the treatment of infectious bronchitis of chicken.
Background technology
Infectious bronchitis of chicken is a kind of acute height contact respiratory infectious disease being caused by avian infectious bronchitis virus.It is characterized in that dyspnea, send rale, cough, mouth breathing, sneeze.Primary disease infected chicken, without obvious breed difference.The chicken of various ages in days is susceptible all, but chicken symptom in 5 week age is more obvious, and mortality rate can arrive 15～19%.Morbidity season is more common in Qiu Mozhi spring Mo next year, but the most serious with winter, is one of principal disease of harm poultry husbandry.
The pathogen of primary disease belongs to coronaviridae coronavirus genus, and low temperature is had to certain resistance, has very strong variability, has isolated in the world at present more than 30 serotype.This disease almost spreads all over the world all poultry country, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antiviral Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And various antiviral drugs ban use of as Ministry of Agriculture such as ribavirin, amantadines.
Therefore researching and developing a kind of drug residue free of infectious bronchitis of chicken, the generation that has no drug resistance, the significant specific medicament of clinical effectiveness for the treatment of is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the herbal mixture composition and method of making the same of effective treatment infectious bronchitis of chicken of drug residue.
For achieving the above object, implementation of the present invention is as follows: a kind of herbal mixture compositions for the treatment of infectious bronchitis of chicken, by following component by weight mixed preparing form: propolis 15-25 part, chicken are with interferon 5-15 part, Folium Isatidis 10-35 part, Herba Ephedrae 15-30 part, Radix Scutellariae 10-30 part, Radix Platycodonis 10-35 part and Radix Glycyrrhizae 15-35 part.
Described various component optimum ratio amount is: 30 parts, 20 parts of propolis, 10 parts of interferon for chicken, 25 parts of Folium Isatidiss, 20 parts, Herba Ephedrae, 20 parts of Radix Scutellariaes, 25 parts of Radix Platycodoniss and Radix Glycyrrhizae.
Treat a preparation method for the herbal mixture compositions of infectious bronchitis of chicken, carry out as follows:
(1) the various compositions except interferon in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-25 part, chicken with interferon 5-15 part, Folium Isatidis 10-35 part and Herba Ephedrae 15-30 part, mix 5-10 minute to even;
(3) take by weight Radix Scutellariae 10-30 part, Radix Platycodonis 10-35 part and Radix Glycyrrhizae 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, return spleen, stomach warp, the function that there is anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic is oxidized, stops blooding, protects gastrointestinal mucosa.
Interferon: be a kind of broad-spectrum disease resistance toxic agent, RNA and DNA viruses are had to inhibition or killing action; Can inducing apoptosis of tumour cell, thus killing off tumor cells; Interferon all has immunological enhancement to humoral immunization, cellular immunization, macrophage and NK cell.
Folium Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly calentura and send out speckle, laryngopharynx swelling and pain, hematodiarrhoea, jaundice, carbuncle, erysipelas etc.
Herba Ephedrae: micro-hardship, temperature, pungent, return lung, urinary bladder channel, there is the function of the cold expelling that induces sweat, depressed lung-energy dispersing, inducing diuresis to remove edema; Cure mainly affection of exogenous wind-cold, cough, asthma, edema etc.
Radix Platycodonis: bitter, pungent, flat, return lung meridian, there is lung qi dispersing, eliminate the phlegm, the function of sore-throat relieving, evacuation of pus; Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess etc.
Radix Scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, there is heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive function; Cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, high heat are greedyly drunk, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus, frequent fetal movement etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for pathogenic microorganism and the clinical symptoms of infectious bronchitis of chicken, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, can also can drink water by spice, and curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Six-element Chinese medicine, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, treatment infectious bronchitis of chicken is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of herbal mixture composition and method of making the same for the treatment of infectious bronchitis of chicken: carry out as follows: (every part by 10g)
(1) the various compositions except interferon in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of propolis, 150 parts, 50 parts of interferon for chicken, 100 parts of Folium Isatidiss and Herba Ephedrae, mix 5-10 minute to evenly;
(3) take by weight 150 parts, 100 parts of Radix Scutellariaes, 100 parts of Radix Platycodoniss and Radix Glycyrrhizae, mix 5-10 minute to evenly;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of infectious bronchitis of chicken and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions except interferon in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 200 parts of propolis, 200 parts, 100 parts of interferon for chicken, 200 parts of Folium Isatidiss and Herba Ephedrae, mix 5-10 minute to evenly;
(3) take by weight 200 parts, 200 parts of Radix Scutellariaes, 200 parts of Radix Platycodoniss and Radix Glycyrrhizae, mix 5-10 minute to evenly;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of infectious bronchitis of chicken and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions except interferon in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of propolis, 300 parts, 150 parts of interferon for chicken, 350 parts of Folium Isatidiss and Herba Ephedrae, mix 5-10 minute to evenly;
(3) take by weight 350 parts, 300 parts of Radix Scutellariaes, 350 parts of Radix Platycodoniss and Radix Glycyrrhizae, mix 5-10 minute to evenly;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
By the ill poultry of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 140kg feeds, and the 260kg that drinks water, every day 2-3 time, is used in conjunction 3-5 day; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.
Table is the field applicable cases contrast of the present invention and other medicines treatment infectious bronchitis of chicken:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 16.7 | 40.8 | 42.5 |
| II | Chicken passes the loose group of a health | 7.7 | 78.9 | 13.4 |
| III | Chinese drug-treated group of the present invention | 4.9 | 87.9 | 7.2 |
This clinical effectiveness statistical analysis, present composition treatment group passes the loose group of a health with chicken and aspect cure rate, is comparing difference extremely significantly (P<0.01).
Above-mentioned detailed description of pure Chinese medicine composition of this treatment infectious bronchitis of chicken and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a herbal mixture compositions for infectious bronchitis of chicken, it is characterized in that by following component by weight mixed preparing form: propolis 15-25 part, chicken are with interferon 5-15 part, Folium Isatidis 10-35 part, Herba Ephedrae 15-30 part, Radix Scutellariae 10-30 part, Radix Platycodonis 10-35 part and Radix Glycyrrhizae 15-35 part.
2. a kind of herbal mixture compositions for the treatment of infectious bronchitis of chicken according to claim 1, is characterized in that described various component optimum ratio amount is: 30 parts, 20 parts of propolis, 10 parts of interferon for chicken, 25 parts of Folium Isatidiss, 20 parts, Herba Ephedrae, 20 parts of Radix Scutellariaes, 25 parts of Radix Platycodoniss and Radix Glycyrrhizae.
3. a preparation method for the herbal mixture compositions for the treatment of infectious bronchitis of chicken according to claim 1, is characterized in that carrying out as follows:
(1) the various compositions except interferon in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-25 part, chicken with interferon 5-15 part, Folium Isatidis 10-35 part and Herba Ephedrae 15-30 part, mix 5-10 minute to even;
(3) take by weight Radix Scutellariae 10-30 part, Radix Platycodonis 10-35 part and Radix Glycyrrhizae 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110306912.8A CN102370972B (en) | 2011-10-12 | 2011-10-12 | Compound Chinese medicine composition for treating infectious bronchitis of chicken and preparation method thereof |
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| CN201110306912.8A CN102370972B (en) | 2011-10-12 | 2011-10-12 | Compound Chinese medicine composition for treating infectious bronchitis of chicken and preparation method thereof |
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| CN102370972A CN102370972A (en) | 2012-03-14 |
| CN102370972B true CN102370972B (en) | 2014-05-07 |
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| CN201110306912.8A Expired - Fee Related CN102370972B (en) | 2011-10-12 | 2011-10-12 | Compound Chinese medicine composition for treating infectious bronchitis of chicken and preparation method thereof |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641474B (en) * | 2012-05-03 | 2014-06-18 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating chicken mycoplasmosis and preparation method thereof |
| CN105519812A (en) * | 2016-01-01 | 2016-04-27 | 闫冷 | Chick infectious broncheitis treatment feed additive |
| CN105999142A (en) * | 2016-05-27 | 2016-10-12 | 商良书 | Traditional Chinese medicine composition for preventing and treating avian infectious bronchitis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1689586A (en) * | 2004-04-20 | 2005-11-02 | 成都思摩纳米技术有限公司 | Application of nano propolis in resistance of influenza virus, respiratory syncytial virus and bird infected bronchitis virus |
| CN101259160A (en) * | 2008-04-18 | 2008-09-10 | 天津生机集团股份有限公司 | Compound preparations for treating birdsvirosis and preparation thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1689586A (en) * | 2004-04-20 | 2005-11-02 | 成都思摩纳米技术有限公司 | Application of nano propolis in resistance of influenza virus, respiratory syncytial virus and bird infected bronchitis virus |
| CN101259160A (en) * | 2008-04-18 | 2008-09-10 | 天津生机集团股份有限公司 | Compound preparations for treating birdsvirosis and preparation thereof |
Non-Patent Citations (4)
| Title |
|---|
| 中草药防治畜禽病毒病的研究进展;张展 等;《畜牧兽医杂志》;20081231;第27卷(第3期);43-64 * |
| 干扰素在治疗肉鸡肾型传染性支气管炎上的应用;许英民;《家禽科学》;20070331(第3期);29-30 * |
| 张展 等.中草药防治畜禽病毒病的研究进展.《畜牧兽医杂志》.2008,第27卷(第3期),43-64. |
| 许英民.干扰素在治疗肉鸡肾型传染性支气管炎上的应用.《家禽科学》.2007,(第3期),29-30. |
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