CN103599362A - Traditional Chinese medicine composition for treating swine enzootic pneumonia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating swine enzootic pneumonia and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating swine enzootic pneumonia. The compound traditional Chinese medicine composition is prepared from the following mixed components in parts by weight: 15-35 parts of rhizoma nardostachyos, 15-35 parts of licorice, 15-35 parts of Chinese mahonia stem, 15-35 parts of radix polygonati officinalis, 15-45 parts of fruit of thinleaf adina, 15-35 parts of trichosanthes peel, 15-40 parts of compound of glauber-salt and licorice, 15-45 parts of Sculellaria barbata, 15-45 parts of Chinese lobelia and 15-45 parts of loofah sponge. The compound traditional Chinese medicine composition has the beneficial effects that the components are reasonable, the preparation method is simple, the composition does not have toxic and side effects, pollution, drug residue and drug resistance, is in superfine grinding, high in bioavailability and very obvious in curative effect and is clinically proved to have a special effect for treating swine enzootic pneumonia.
Description
Technical field
The present invention relates to Chinese medicine composition for the treatment of swine enzootic pneumonia and preparation method thereof, belong to animal field of medicaments, particularly a kind of Chinese medicine composition that is specifically designed to treatment swine enzootic pneumonia and preparation method thereof.
Background technology
Swine enzootic pneumonia is a kind of contact respiratory infectious disease being caused by mycoplasma hyopneumoniae, take and coughs, pants as feature, once infect on pig farm, is difficult to thoroughly eliminate.The pig of various ages and kind all can occur, and M & M is all between 5%-20%.Primary disease all can occur throughout the year, is one of principal disease of serious harm pig industry.
This disease almost spreads all over all countries of raising pigs in the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug is because life-time service has drug residue and easily produces drug resistance, and worse and worse, and drug residue causes exporting limited and harm people are healthy for its clinical effectiveness, thereby the use of antimicrobial drug is very restricted.
Therefore research and develop and a kind ofly treat the drug residue free of swine enzootic pneumonia, the specific medicament producing that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the Chinese medicine composition of effective treatment swine enzootic pneumonia of drug residue and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of Chinese medicine composition for the treatment of swine enzootic pneumonia, by following component by weight mixed preparing form: Radix Et Rhizoma Nardostachyos 15-35 part, Radix Glycyrrhizae 15-35 part, Caulis Mahoniae 15-35 part, Rhizoma Polygonati Odorati 15-35 part, Fructus Adinae 15-45 part, Pericarpium Trichosanthis 15-35 part, Matrii Sulfas Exsiccatus 15-40 part, Herba Scutellariae Barbatae 15-45 part, Herba Lobeliae Chinensis 15-45 part, Retinervus Luffae Fructus 15-45 part.
Described various component optimum ratio amount is: 25 parts of Radix Et Rhizoma Nardostachyos, 25 parts, Radix Glycyrrhizae, 25 parts of Caulis Mahoniaes, 25 parts of Rhizoma Polygonati Odorati, 30 parts of Fructus Adinaes, 25 parts of Pericarpium Trichosanthiss, 30 parts of Matrii Sulfas Exsiccatus, 30 parts of Herba Scutellariae Barbataes, 30 parts of Herba Lobeliae Chinensis, 30 parts of Retinervus Luffae Fructuss.
Treating a preparation method for the Chinese medicine composition of swine enzootic pneumonia, is to carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Radix Et Rhizoma Nardostachyos 15-35 part, Radix Glycyrrhizae 15-35 part, Caulis Mahoniae 15-35 part, Rhizoma Polygonati Odorati 15-35 part, Fructus Adinae 15-45 part, mix 5-10 minute to even;
(3) take by weight Pericarpium Trichosanthis 15-35 part, Matrii Sulfas Exsiccatus 15-40 part, Herba Scutellariae Barbatae 15-45 part, Herba Lobeliae Chinensis 15-45 part, Retinervus Luffae Fructus 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Radix Et Rhizoma Nardostachyos: sweet, pungent, warm, return spleen, stomach warp, the function that there is regulating QI to relieve pain, cold expelling dampness, is amusing and whets the appetite; Cure mainly cold-damp disturbing the spleen, tripe distention and fullness in the abdomen, skin infection etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Caulis Mahoniae: bitter, cold, return liver, large intestine, stomach warp, there is the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly the yellow dysentery of intestinal, jaundice due to damp-heat, conjunctival congestion and swelling pain, laryngopharynx swelling and pain, sore etc.
Rhizoma Polygonati Odorati: sweet, cold, attach to the lung and stomach meridians, there is the function of nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid; Cure mainly dryness of the lung dry cough, gastric heat, consumption of YIN caused by febrile disease, deficient fever etc.
Fructus Adinae: bitter, puckery, cool, GUIXIN, small intestinal, lung meridian, have the function of heat-clearing and toxic substances removing; Cure mainly cold, fever, laryngopharynx swelling and pain, dysentery etc.
Pericarpium Trichosanthis: sweet, cold, attach to the lung and stomach meridians, there is removing heat-phlegm, the function of the eliminating stagnation of regulating the flow of vital energy; Cure mainly lung-heat cough with asthma, chest and diaphragm is had a pain etc.
Matrii Sulfas Exsiccatus: salty, bitter, cold, return stomach, large intestine channel, there is the function of purging heat to relax the bowels, moistening for dryness and softening hard mass, clearing heat for detumescence; Cure mainly constipated, the stagnant stomachache of feces, excess-heat constipation, laryngopharynx swelling and pain, aphtha of the mouth and tongue, conjunctival congestion, carbuncle etc.
Herba Scutellariae Barbatae: pungent, bitter, cold, return lung, liver, kidney channel, there is the function of heat-clearing and toxic substances removing, blood stasis dispersing and deswelling, diuresis; Cure mainly diarrhea due to damp-heat, furuncle swelling toxin, laryngopharynx swelling and pain, edema, jaundice etc.
Herba Lobeliae Chinensis: pungent, flat, GUIXIN, small intestinal, lung meridian, have the function of heat-clearing and toxic substances removing, inducing diuresis to remove edema; Cure mainly edema, carbuncle furuncle etc.
Retinervus Luffae Fructus: sweet, flat, return stomach, liver, lung meridian, the function of there is dredging collateral, invigorate blood circulation, dispeling the wind; Cure mainly rheumatic arthralgia, limbs contracture, galactostasis etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for clinical symptoms and the pathological change of swine enzootic pneumonia, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Ten Herbs, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, treatment swine enzootic pneumonia is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of Chinese medicine composition for the treatment of swine enzootic pneumonia and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of Radix Et Rhizoma Nardostachyos, 150 parts, Radix Glycyrrhizae, 150 parts of Caulis Mahoniaes, 150 parts of Rhizoma Polygonati Odorati, 150 parts of Fructus Adinaes, mix 5-10 minute to even;
(3) take by weight 150 parts of Pericarpium Trichosanthiss, 150 parts of Matrii Sulfas Exsiccatus, 150 parts of Herba Scutellariae Barbataes, 150 parts of Herba Lobeliae Chinensis, 150 parts of Retinervus Luffae Fructuss, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of Chinese medicine composition for the treatment of swine enzootic pneumonia and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of Radix Et Rhizoma Nardostachyos, 250 parts, Radix Glycyrrhizae, 250 parts of Caulis Mahoniaes, 250 parts of Rhizoma Polygonati Odorati, 300 parts of Fructus Adinaes, mix 5-10 minute to even;
(3) take by weight 250 parts of Pericarpium Trichosanthiss, 300 parts of Matrii Sulfas Exsiccatus, 300 parts of Herba Scutellariae Barbataes, 300 parts of Herba Lobeliae Chinensis, 300 parts of Retinervus Luffae Fructuss, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of Chinese medicine composition for the treatment of swine enzootic pneumonia and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of Radix Et Rhizoma Nardostachyos, 350 parts, Radix Glycyrrhizae, 350 parts of Caulis Mahoniaes, 350 parts of Rhizoma Polygonati Odorati, 450 parts of Fructus Adinaes, mix 5-10 minute to even;
(3) take by weight 350 parts of Pericarpium Trichosanthiss, 400 parts of Matrii Sulfas Exsiccatus, 450 parts of Herba Scutellariae Barbataes, 450 parts of Herba Lobeliae Chinensis, 450 parts of Retinervus Luffae Fructuss, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
Clinical experiment animal is selected 120-130 age in days, the ill pig that Laboratory Diagnosed is swine enzootic pneumonia.Ill pig isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experiment is carried out 8 days altogether; Blank group is left intact, and medicine matched group is used treatment by institute's control drug by its description; Chinese medicine composition group of the present invention can be by product of the present invention (the prepared compositions of the embodiment of the present invention 2) the ill pig of feeding etc., and a day dose is: by the every 100g spice of the present invention 200kg, feed or the 400kg that drinks water, every day 2-3 time, be used in conjunction 3-5 day; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result when following table is experiment end.
Efficacy assessment standard:
Healing: spirit is normal, the clinical symptom disappearance such as it is normal to drink water, and breathing is normal, and feces is normal of searching for food, detect and have no mycoplasma etc. through direct fluorescence detection in pig tracheal secretion.
During end, there is symptom: clinical symptoms is not improved and even increased the weight of.
Table is the field applicable cases contrast of the present invention and other medicines treatment swine enzootic pneumonia:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 33.3 | 3.3 | 63.4 |
| II | The loose group of pig asthma health | 6.7 | 73.3 | 20 |
| III | Present composition group | 3.3 | 80 | 16.7 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared significant difference (P<0.05) with the loose group of pig asthma health aspect cure rate.
Safety testing:
Choose 10 of 90 age in days health pig, according to 5 times of spices of the made compositions recommended dose of the embodiment of the present invention 2, feed or drink water 10 days, during medication, health pig is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of Chinese medicine composition of this treatment swine enzootic pneumonia and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a Chinese medicine composition for swine enzootic pneumonia, it is characterized in that by following component by weight mixed preparing form: Radix Et Rhizoma Nardostachyos 15-35 part, Radix Glycyrrhizae 15-35 part, Caulis Mahoniae 15-35 part, Rhizoma Polygonati Odorati 15-35 part, Fructus Adinae 15-45 part, Pericarpium Trichosanthis 15-35 part, Matrii Sulfas Exsiccatus 15-40 part, Herba Scutellariae Barbatae 15-45 part, Herba Lobeliae Chinensis 15-45 part, Retinervus Luffae Fructus 15-45 part.
2. the Chinese medicine composition for the treatment of swine enzootic pneumonia according to claim 1, is characterized in that described various component optimum ratio amount is: 25 parts of Radix Et Rhizoma Nardostachyos, 25 parts, Radix Glycyrrhizae, 25 parts of Caulis Mahoniaes, 25 parts of Rhizoma Polygonati Odorati, 30 parts of Fructus Adinaes, 25 parts of Pericarpium Trichosanthiss, 30 parts of Matrii Sulfas Exsiccatus, 30 parts of Herba Scutellariae Barbataes, 30 parts of Herba Lobeliae Chinensis, 30 parts of Retinervus Luffae Fructuss.
3. a preparation method for the Chinese medicine composition for the treatment of swine enzootic pneumonia according to claim 1 and 2, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Radix Et Rhizoma Nardostachyos 15-35 part, Radix Glycyrrhizae 15-35 part, Caulis Mahoniae 15-35 part, Rhizoma Polygonati Odorati 15-35 part, Fructus Adinae 15-45 part, mix 5-10 minute to even;
(3) take by weight Pericarpium Trichosanthis 15-35 part, Matrii Sulfas Exsiccatus 15-40 part, Herba Scutellariae Barbatae 15-45 part, Herba Lobeliae Chinensis 15-45 part, Retinervus Luffae Fructus 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103947887A (en) * | 2014-05-09 | 2014-07-30 | 山东新希望六和集团有限公司 | Feed for preventing and treating mycoplasmal pneumonia of swine and traditional Chinese medicine composition as well as preparation method |
| CN105104858A (en) * | 2015-08-28 | 2015-12-02 | 方标嵩 | Disease-resistant traditional Chinese medicine additive for fermented feed of wild porkers |
| CN105104857A (en) * | 2015-08-28 | 2015-12-02 | 方标嵩 | Fermented feed for feeding wild porkers and production method thereof |
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| CN1043262A (en) * | 1989-12-08 | 1990-06-27 | 吕金博 | One boar is used the compound method of Chinese herbal medicine powder |
| CN102210813A (en) * | 2011-05-31 | 2011-10-12 | 徐斯润 | Traditional Chinese medicine composition for diminishing inflammation and relieving toxicity for livestock and poultry and preparation method thereof |
| CN102240329A (en) * | 2011-07-01 | 2011-11-16 | 佛山科学技术学院 | Chinese medicinal preparation for preventing and treating livestock lung heat syndrome |
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- 2013-11-12 CN CN201310581563.XA patent/CN103599362B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1043262A (en) * | 1989-12-08 | 1990-06-27 | 吕金博 | One boar is used the compound method of Chinese herbal medicine powder |
| CN102210813A (en) * | 2011-05-31 | 2011-10-12 | 徐斯润 | Traditional Chinese medicine composition for diminishing inflammation and relieving toxicity for livestock and poultry and preparation method thereof |
| CN102240329A (en) * | 2011-07-01 | 2011-11-16 | 佛山科学技术学院 | Chinese medicinal preparation for preventing and treating livestock lung heat syndrome |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103947887A (en) * | 2014-05-09 | 2014-07-30 | 山东新希望六和集团有限公司 | Feed for preventing and treating mycoplasmal pneumonia of swine and traditional Chinese medicine composition as well as preparation method |
| CN103947887B (en) * | 2014-05-09 | 2015-08-12 | 山东新希望六和集团有限公司 | A kind of feed, Chinese medicine composition and preparation method for preventing and treating swine enzootic pneumonia |
| CN105104858A (en) * | 2015-08-28 | 2015-12-02 | 方标嵩 | Disease-resistant traditional Chinese medicine additive for fermented feed of wild porkers |
| CN105104857A (en) * | 2015-08-28 | 2015-12-02 | 方标嵩 | Fermented feed for feeding wild porkers and production method thereof |
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| CN103599362B (en) | 2016-02-24 |
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Effective date of registration: 20190628 Address after: 510507 No. 180 Tianyuan Road, Tianhe District, Guangzhou City, Guangdong Province, Pavilion 113A, Yangming (International) Agricultural Commodity Exchange City, Guangzhou City Patentee after: Guangzhou and Biotechnology Co., Ltd. Address before: 266000 No. 66, Nan Wang Industrial Park, Licang District, Qingdao, Shandong. Patentee before: Qingdao Lvman Biological Engineering Co., Ltd. |
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